Summary of the invention
The object of the present invention is to provide a kind of improvement and lipotropic compositions, this compositions has blood lipid regulation, liver-protective effect, and toxic and side effects is little.
In a kind of improvement and lipotropic compositions involved in the present invention, contain Monas cuspurpureus Went extract, Fructus Schisandrae Chinensis extrat and Herba Silybi mariani extract.
Monas cuspurpureus Went extract is 0.02~20% in its weight percentage of lovastatin in the compositions, Fructus Schisandrae Chinensis extrat is 0.05~30% in its weight percentage of schisandrin B, and Herba Silybi mariani extract is 0.05~50% in its weight percentage of silymarin.
Monas cuspurpureus Went extract is 0.1~5% in the lovastatin weight percentage in the preferred composition, and Fructus Schisandrae Chinensis extrat is 0.2~10% in the schisandrin B weight percentage, and Herba Silybi mariani extract is 0.2~20% in the silymarin weight percentage.
Further Monas cuspurpureus Went extract is 1% in the lovastatin weight percentage in the preferred composition, and Fructus Schisandrae Chinensis extrat is 2% in the schisandrin B weight percentage, and Herba Silybi mariani extract is 10% in the silymarin weight percentage.
Described Monas cuspurpureus Went extract is a main active with the lovastatin, and lovastatin accounts for 0.4~99% by weight percentage in the Monas cuspurpureus Went extract; Described Fructus Schisandrae Chinensis extrat is a main active with the schisandrin B, and schisandrin B accounts for 5~99% by weight percentage in the Fructus Schisandrae Chinensis extrat; Described Herba Silybi mariani extract is a main active with the silymarin, and silymarin accounts for 40~99% by weight percentage in the Herba Silybi mariani extract.
Described compositions is made acceptable dosage form clinically with acceptable adjuvant medically.
The dosage form of described compositions can be tablet, capsule, granule, powder, pill, drop pill, mixture, injection and other clinical acceptable preparation.
The preparation of described compositions can be ordinary preparation, quick releasing formulation, sustained-release preparation and other clinical acceptable preparation.
Described compositions is improved and control fatty liver medicine and the application in accent fat liver-protecting health food in preparation.
The sweet temperature of Monas cuspurpureus Went is gone into hepatosplenomegaly intestinal warp, energy blood circulation promoting and blood stasis dispelling, strengthening the spleen to promote digestion.Monas cuspurpureus Went head sees principle of Correct Diet, claims its sweet in the mouth flat, nontoxic, and the effect of spleen invigorating, QI invigorating, warming middle-JIAO is arranged; " Bencao Jingshu " says that it helps digestion, spleen invigorating is identical with Massa Medicata Fermentata, and invigorates blood circulation and hinder, and is can with the Monas cuspurpureus Went; " Amplification on Materia Medica addendum " claims it to invigorate blood circulation to help digestion the spleen invigorating warming the stomach; " Chinese medicine dictionary " claims its energy blood circulation promoting and blood stasis dispelling, strengthening the spleen to promote digestion, treatment prolonged lochia, the stagnant stomachache of the stasis of blood, glutted, the red white dysentery of food stagnation and traumatic injury.Modern pharmacology confirms that Monas cuspurpureus Went can act on lipometabolic different link, as absorption by the exogenous cholesterol of interference, suppress the metabolism of endogenous cholesterol, be rich in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and multiple unsaturated fatty acid, TC and TG be can effectively reduce, and multiple essential amino acids and trace element in the human body contained.Effective ingredient lovastatin in the Monas cuspurpureus Went is used for the treatment of hyperlipidemia, is one of world's situation of selling well medicine.The effect of Monas cuspurpureus Went extract is better than lovastatin, and safety has no side effect.
Herba Silybi mariani hardship, cold have the effect of heat-clearing and toxic substances removing, nourishing the liver function of gallbladder promoting.Modern study shows to have stable liver plasma membrane, and the protection hepatocyte is without prejudice, and improves the effect of liver function, and serum cholesterol-lowering reduces the liver fat deposition, removes oxygen-derived free radicals in the body, to the effect of anti peroxidation of lipid and direct or indirect anti-hepatic fibrosis.Effective ingredient in the Herba Silybi mariani is mainly flavonoid, wherein mainly contains silibinin, Isosilybin, silidianin, Silychristin etc.According to modern pharmacological research; silymarin has the free radical resisting activity, removes active oxygen and antagonism lipid oxidation; suppress NO production; suppress 5 '-lipoxygenase; the protection liver plasma membrane; promote that hepatocyte is repaired, regeneration, many-sided pharmacological activity such as immunoregulation effect, the corresponding link that these effects can prevent fatty liver to take place.At present the preparation of being made by Herba Silybi mariani extract is widely used in the acute, chronic hepatitis that a variety of causes causes and the treatment of liver cirrhosis, and the control fatty liver is more satisfactory, determined curative effect, and toxic and side effects is little.Trimethyl gallic acid, sweet, temperature is returned lung, the heart, kidney channel, has the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming.Chinese Magnoliavine Fruit alcohol extract and deoxyschizandrin, second element, third element, pure first, pure second, ester first, ester the second grade have obvious protective effect to the animal liver cell damage that chemical toxicant causes, can suppress transaminase's release, make the active reduction of ALT.Can obvious inducing mouse and rat liver microsomes cytochrome P-450 activity.Can promote liver glycogen heteroplasia and liver glycogen to decompose.Increase the liver detoxification ability.The carbon monoxide that Fructus Schisandrae Chinensis generates after the hepatomicrosome metabolic conversion CCl4 and in metabolic process the consumption to NADPH also inhibitory action can be arranged.Fructus Schisandrae Chinensis also has enhance immunity, slow down aging, antioxidation, effects such as antitumor.
Fatty liver is owing to liver inner lipid too high levels, thereby causes the disease of abnormal liver function.So most patient's hyperlipemia and abnormal liver function are also deposited.Heavy dose of use lipid-regulation medicine as Statins, the special class of shellfish, because lipid-regulation medicine is thanked at liver mostly, raises so can cause slight transaminase, heavy dose of life-time service lipid-regulation medicine, and the transaminase certainly will further raise.Though it is normal that the result is a blood fat, liver function further worsens.And many lipid-regulation medicines may order about blood fat and more concentrate on liver metabolism, impel accumulation of lipid on the contrary and damage liver function.So in the treatment of fatty liver, answer the coupling hepatic when using fat regulation medicine.In the compositions provided by the present invention, contain Monas cuspurpureus Went extract, Fructus Schisandrae Chinensis extrat, Herba Silybi mariani extract,, utilize the synergism of three kinds of compositions, make this compositions have the effect of blood lipid regulation hepatoprotective by selection to the reasonable science of its consumption.Said composition is had in mind from transferring fat and hepatoprotective two aspects at the pathogenesis of fatty liver, and side effect is low, and the adverse consequencess such as hepatic injury of having avoided independent application lipid-regulation medicine to cause have strengthened lipid-lowering effect again, can be used for improving and the control fatty liver.The beneficial effect of compositions of the present invention is confirmed by pharmacodynamic experiment and patient's result on trial.
The specific embodiment:
Below in conjunction with specific embodiment improvement and lipotropic compositions among the present invention are further described.
Embodiment 1
Improve and lipotropic compositions, it is to be made by following weight percentages:
Monas cuspurpureus Went extract (in lovastatin) 0.02,0.1,0.5,1,2,5,10 or 20
Fructus Schisandrae Chinensis extrat (in schisandrin B) 0.05,0.2,1,2,5,10,15 or 30
Herba Silybi mariani extract (in silymarin) 0.05,0.2,5,10,15,20,30 or 50
Method for making 1: get above-mentioned raw materials and be ground into fine powder,, make tablet, capsule or granule with auxiliary materials and mixing.
Method for making 2: get above-mentioned raw materials and be ground into fine powder, other gets PFG4000 heating melting, adds above-mentioned fine powder, stirs evenly, and pulverizes after the condensation, adds auxiliary materials and mixing, makes tablet, capsule or granule.
Method for making 3: get above-mentioned raw materials and be ground into fine powder, other gets PEG heating melting, adds above-mentioned fine powder, stirs evenly, and splashes in the condensed fluid, makes drop pill.
The inventory of the listed Monas cuspurpureus Went extract among this embodiment is the inventory in lovastatin, and actual feeding intake converted corresponding inventory according to the content of lovastatin in the used Monas cuspurpureus Went extract.The amount that used Monas cuspurpureus Went extract contains lovastatin during the throwing amount can be arbitrary content of 0.4~99%.
The inventory of the listed Fructus Schisandrae Chinensis extrat among this embodiment is the inventory in schisandrin B, and actual feeding intake converted corresponding inventory according to the content of schisandrin B in the used Fructus Schisandrae Chinensis extrat.The amount that used Fructus Schisandrae Chinensis extrat contains schisandrin B during the throwing amount can be arbitrary content of 0.5~99%.
The inventory of the listed Herba Silybi mariani extract among this embodiment is the inventory in silymarin, and actual feeding intake converted corresponding inventory according to the content of silymarin in the used Herba Silybi mariani extract.The moisture amount that flies silibin of used Herba Silybi mariani extract can be arbitrary content of 20~99% during the throwing amount.
Also can adopt other routine fashion to make acceptable clinically other any dosage form.
Embodiment 2
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 4%) 125g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 9%) 111g
Herba Silybi mariani extract (silymarin content is 80%) 62.5g
Method for making: get above-mentioned raw materials and be ground into fine powder, with encapsulated behind the starch 201.5g mixing, every dress 0.25g.
Using method is: oral, and each 2, every day 2~3 times.
Embodiment 3
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 1%) 250g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 15%) 65g
Herba Silybi mariani extract (silymarin content is 80%) 125g
Method for making: get above-mentioned raw materials and be ground into fine powder, with encapsulated behind the starch 60g mixing, every dress 0.25g.
Using method is: oral, and each 2, every day 2~3 times.
Embodiment 4
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 8%) 62.5g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 50%) 20g
Herba Silybi mariani extract (silymarin content is 85%) 94g
Method for making: get above-mentioned raw materials and be ground into fine powder, get 323.5gPFG4000 heating melting, add above-mentioned fine powder, stir evenly, pulverize after the condensation, incapsulate, every dress 0.25g.
Using method is: oral, and each 2, every day 2~3 times.
Embodiment 5
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 30%) 16.7g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 10%) 100g
Herba Silybi mariani extract (silymarin content is 60%) 133.3g
Method for making: get above-mentioned raw materials and be ground into fine powder, get 250gPFG4000 heating melting, add above-mentioned fine powder, stir evenly, pulverize after the condensation, incapsulate, every dress 0.25g.
Using method is: oral, and each 2, every day 2~3 times.
Embodiment 6
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 50%) 5g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 30%) 16.7g
Herba Silybi mariani extract (silymarin content is 90%) 27.8g
Method for making: get above-mentioned raw materials and be ground into fine powder, get 200.5gPFG4000 heating melting, add above-mentioned fine powder, stir evenly, pulverize after the condensation, incapsulate, every dress 0.25g.
Using method is: oral, and each 1, every day 2~3 times.
Embodiment 7
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 60%) 8.3g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 60%) 16.7g
Herba Silybi mariani extract (silymarin content is 95%) 84.2g
Method for making: get above-mentioned raw materials and be ground into fine powder, with encapsulated behind the starch 140.8g mixing, every dress 0.25g.
Using method is: oral, and each 1, every day 2~3 times.
Embodiment 8
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 90%) 5.5g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 90%) 11.1g
Herba Silybi mariani extract (silymarin content is 95%) 84.2g
Method for making: get above-mentioned raw materials and be ground into fine powder,, granulate with starch 146g mixing, with micropowder silica gel 2.5g, magnesium stearate 0.75g mixing, compacting is in blocks, every heavy 0.25g.
Using method is: oral, and each 1, every day 2~3 times.