CN104382893A - Soft capsule adopting VE, VC and curcumin as main medicine components - Google Patents
Soft capsule adopting VE, VC and curcumin as main medicine components Download PDFInfo
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- CN104382893A CN104382893A CN201410574538.3A CN201410574538A CN104382893A CN 104382893 A CN104382893 A CN 104382893A CN 201410574538 A CN201410574538 A CN 201410574538A CN 104382893 A CN104382893 A CN 104382893A
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Classifications
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
The invention belongs to the field of health care products, and discloses composition and a preparation method for a soft capsule adopting Vitamin E, Vitamin C and curcumin as main medicine components. The soft capsule comprises the following active ingredients: 5-70% of curcumin, 5-70% of curcumin extractive, 1.5-8.5% of Vitamin E, and 5-20% of Vitamin C; the supplementary elements are soft capsule auxiliary materials accepted by pharmacology. The soft capsule is high in availability of raw materials, and low in preparation cost, has no toxic side effect, and is safe to take, and easy to store, carry and take.
Description
Technical field
The invention belongs to field of health care products, be specifically related to a kind of with vitamin E, vitamin C and curcumin constituent that is the soft capsule of principal agent composition and preparation method thereof.
Background technology
Rhizoma Curcumae Longae is the herbaceos perennial of Curcuma.Rhizoma Curcumae Longae is irregular oval, cylindrical or stricture of vagina capitate.The powder that Rhizoma Curcumae Longae dry rhizome grinds, as flavoring agent and yellow colorants, is the common flavouring agent that family uses, for curry powder, flavouring agent etc.Rhizoma Curcumae Longae is a kind of perennial dulcet herbaceous plant, and existing medical value, can make food seasoning again.Xin Xiang is pastel, slightly Fructus Piperis, Moschus taste and Fructus Citri sinensis and Rhizoma Zingiberis Recens mix taste, slightly pungent, bitterness.
Curcumin extraction, typically refers to curcumin, volatile oil, turmerone and zingiberene, Borneolum Syntheticum and sesquiterpenoid etc., has choleretic effect, can increase generation and the secretion of bile, and can promote gallbladder contraction, wherein the strongest with the effect of curcumin again.Its effect: 1. anti-oxidation function, with slow down aging.The free radical that ultraviolet produces can be resisted, and then the effect of skin anti-aging can be reached, therefore be referred to as " oral skin care product ".2. catch free radical, reduce threats.Free radical is the major reason of many chronic diseases and formation of cancer, is also the arch-criminal making human senescence simultaneously.Free radical constantly can destroy normal cell, allows health produce disease.Curcumin can catch free radical, indirectly has preventive effect to kinds cancer, is therefore more called as natural anti-cancer agent.3. gastrointestinal function and liver function is strengthened.Curcumin can stimulate stomachial secretion mucoprotein (Mucin), and protection gastric mucosa avoids impaired, especially quite effective for chronic gastric ulcer.In daily life, curcumin can make the decomposition rate of acetaldehyde bring up to 1.5 times.Thus can be still drank after a night by Rapid reversal.For hepatopath, curcumin also has suppression hepatitis, repairs the hepatocyte of damage, improves the effects such as liver parenchyma damage.4. cholesterol is reduced.Curcumin can reduce T-CHOL and reach 11.6%, and can improve HDL up to 29%, contributes to the generation of angiocardiopathy preventing.The inflammation such as rheumatism, arthralgia can also be suppressed, obesity, delay skin aging and beauty functions simultaneously.
Effective ingredient in Rhizoma Curcumae Longae is slightly acid phenolic substance.Have and promote that macrophage is formed, thus improve the function of immunity of organisms; This immunocyte can remove amyloplaste (a kind of energy forms the brain plaque material be associated with senile dementia), thus reaches effect of prevention and therapy senile dementia.Now prove that curcumin has good effect to the generation of Breast Cancer Prevention and carcinoma of prostate and development; Simultaneously curcumin also have that function of gallbladder promoting protects the liver, blood fat reducing, promoting blood circulation to remove obstruction in the collateral, antioxidation, atherosclerosis and the physiology such as antiinflammatory, anti AIDS virus, pharmacological action.
Chinese always have the custom utilizing food to carry out self health care.During spring and autumn, Confucius just advocates: " often eat and do not remove Rhizoma Zingiberis Recens." meaning: people should eat Rhizoma Zingiberis Recens every day throughout the year.It is said that Confucius just has and chew several pieces custom of Rhizoma Zingiberis Recens every day after meal.Among the people have saying of " three Rhizoma Zingiberis Recens, being better than and drinking ginseng soup morning " and " Rhizoma Zingiberis Recens Radix Codonopsis Cardiophyllae in October "." winter eats the Radix Raphani summer and eats Rhizoma Zingiberis Recens, and doctor Lao does not write out a prescription to also have " every day three Rhizoma Zingiberis Recens, not labor doctor prescribed prescription "." proverb such as " often eat Rhizoma Zingiberis Recens, be not afraid of hardships ".Rhizoma Zingiberis Recens in life, except being used as flavoring agent, snack food, also demonstrates local flavor and the glamour of its uniqueness in beauty treatment, health care.Rhizoma Zingiberis Recens is hot in nature, acrid in the mouth.Return spleen, stomach, the heart, lung meridian.Effect: warming middle-JIAO, recuperating depleted YANG, warming the lung to resolve fluid-retention.There are the multiple efficacies such as cold expelling diaphoresis, preventing phlegm from forming and stopping coughing, stomach function regulating, preventing or arresting vomiting.Dry rhizome has promoting the circulation of QI to relieve pain, dysmenorrhea removing blood stasis, effects such as Liao Paralysis of dispeling the wind.Rhizoma Zingiberis head enters taste, hotly by taste cold-evil, can help the yang-energy of taste with it.Commonly use and control taste sympotoms caused by cold factors, disease sees epigastric pain, vomiting is had loose bowels.In every case taste sympotoms caused by cold factors, be no matter invade in exogenous cold or YANG QI deficiency all applicable.Therefore, develop and a kind ofly necessarily have market widely based on the soft capsule of curcumin or curcumin extraction, be bound to be subject to acceptance and the accreditation of consumers in general.
Vitamin E (Vitamin E), also known as tocopherol, is one of topmost fat-soluble antioxidant.Tocopherol can promote sex hormones secretion, and man's motility of sperm and quantity are increased; Woman's estrogen concentration is increased, and improve fertility, prevention of miscarriage, also can be used for preventing and treating the aspects such as male infertility, burn, cold injury, capillary hemorrhage, climacteric syndrome, beauty treatment.Recently also find that vitamin E can suppress the lipid peroxidation in eye lens to react, and makes peripheral vasodilation, improves blood circulation, pre-myopia prevention occurs and development.It can stop unsaturated fatty acid (linoleic acid, arachidonic acid, other electron pair acceptor), vitamin, hormone, enzyme etc. from Oxidative demage, can not only reduce the peroxidating of lipid and lipoprotein on cell membrane, the normal function of Cell protection.The E that is deficient in vitamin can cause hereditary and metabolic disease.Research in the last few years finds, vitamin E has and acts on widely in control cardiovascular and cerebrovascular disease, tumor, diabetes and other complication, central nervous system disease, locomotor disease, dermatosis etc.Vitamin E also has very strong lock aqueous, so there is again the good reputation of deep skin wetting agent.
Vitamin C is water soluble antioxidant, and its effect has the biosynthesis 1. promoting ossein, is beneficial to healing sooner of tissue injury mouth; Promote the synthesis of collagen protein, prevent gingival hemorrhage; Promote the growth of tooth and skeleton, prevent dental bed hemorrhage, prevent arthralgia, lumbago and skelalgia.2. promote the metabolism of tyrosine and tryptophan in aminoacid, extend the human body life-span; Strengthen the human body anti-stress ability of environment and immunity to external world.3. the utilization of ferrum, calcium and folic acid is improved; Improve the metabolism of fat and lipoid particularly cholesterol, prevent cardiovascular diseases.4. prevention of arterial sclerosis.The excretion of cholesterol can be promoted, prevent cholesterol from depositing at Wall of Artery, the atheromatous plaque of deposition even can be made to dissolve.5. antioxidant action.Other antioxidant can be protected, as VA, VE, unsaturated fatty acid, prevent the injury of radical pair human body.In addition, VC also has certain face-nursing function.VC can suppress the increase of pigment, makes freckle thin out, has whitening effect, can reduce pore, increases the effect of collagen protein, adjustment skin texture.
Soft capsule is the novel form grown up after sheet, injection, be by oily medicine, drug solution or drug suspension, the pastel even quantitative pressure injection of drug powder be encapsulated in glued membrane, form size, different seal capsule, available dropping preparation method or pressing preparation.Soft capsule material makes by gelatin, glycerol, plasticizer, antiseptic, opacifier, pigment and other suitable medicinal materials.Its size and form have multiple, there are spherical (0.15 ~ 0.3ml), oval (0.10 ~ 0.5ml), rectangle (0.3 ~ 0.8ml) and tubular (0.4 ~ 4.5ml) etc., different cultivars that is for oral administration or external can be made according to clinical needs, the elasticity of capsule shells is large, therefore also known as elastic capsule or title soft gelatin capsule.Dosage form has plurality of advantages: 1. cover the pungent of content discomfort and wait abnormal flavour, change and make groups of people be difficult to the problem taken, and makes that it is clean and tidy, attractive in appearance, easily swallows.2. dosage is accurate relatively, and degree of accuracy is higher, can reach milligram/grain metering.3. the bioavailability of medicine and medicine stability are all improved.The person that takes soft capsule in test, on average peaks at 1.5h blood level, the person that takes tablet, and on average just peak at 2.5h blood level, the dose of curcumin can keep constant, can observe the effect that different crowd is taken better.4. overcome curcumin unstable easily resolution characteristic in atmosphere, be prepared into soft capsule, effectively by wet and oxygen, light in atmosphere effect, stability can be improved by protection medicine.
The effect of curcumin is wide, good effect.Be typical functional dietetic therapy product, but have certain seasonality because China produces Rhizoma Zingiberis Recens, store difficulty comparatively large, edible process is too complicated, is not easy to long-term, regular or takes at any time, therefore, have impact on its marketability.
At present, mostly the turmeric powder that can buy of market and the health promoting product containing curcumin are imported product.Product category is enriched, and have curcumin capsule, tablet, tea and drinks, primary efficacy is hepatoprotective effect.But because the solubization of turmeric powder and curcumin and extract thereof is poor, and the features such as easy decomposition, greatly hinder the application of curcumin in functional food and health product.The market prospect developing this series health-care products with independent intellectual property right and nutriment is fine.
China enters aging society, health care, improves quality of life and more and more becomes the requirement of people to health product and functional food.The sickness rate of senile dementia increases in China fast with the speed of annual 14%, curcumin be generally acknowledge at present to the effective native compound of prevention and therapy senile dementia.Therefore, such health product and functional food are bound to be subject to the welcome in market.
Summary of the invention
Primary and foremost purpose of the present invention is to provide a kind of based on VE, VC and curcumin, there is certain health-care effect, comprise and there is function of gallbladder promoting protect the liver, increase the effects such as immunity, skin maintenance, anticancer and resisting fatigue, and to anemofrigid cold, chronic gastritis, hyperlipidemia and wound healing have certain soft capsule with therapeutic efficiency of assisting.There is raw material be easy to get, low production cost, have no side effect, edible safety, be convenient to features such as storing, carry and take.
The object of the present invention is to provide above-mentioned a kind of with VE, VC and curcumin constituent that is the soft capsule of principal agent composition and preparation method thereof.
Object of the present invention is achieved through the following technical solutions:
With the soft capsule that VE, VC and curcumin are principal agent composition, be grouped into by the one-tenth of following mass percent:
Curcumin extraction: 5-70%, curcumin: 5-70%, VE:1.5-8.5%, VC:5-20%, adds soft capsule preparation adjuvant, and above composition makes soft capsule.
Curcumin of the present invention and curcumin extraction are all buied from market.
Soft capsule provided by the invention, comprising VE, VC, curcumin and curcumin extraction.
Soft capsule provided by the invention, wherein also comprises the acceptable adjuvant of pharmacy.
Soft capsule provided by the invention, comprising appropriate VE, VC, curcumin extraction or curcumin.
Above-mentioned a kind of preparation that is the soft capsule of principal agent composition with VE, VC and curcumin:
The soft capsule that is principal agent composition with VE, VC and curcumin of the present invention, wherein active component is made up of VE, VC, curcumin extraction and curcumin, and its weight proportion is curcumin: 5-70%, curcumin extraction: 5-70%, vitamin E: 1.5-8.5%, vitamin C: 5-20%; Supplementary element has the soft capsule adjuvants such as soybean oil, soybean phospholipid, gelatin, G & W.Above composition is made soft capsule and be get final product.
The present invention adopts and soft capsule is made in curcumin, VE and VC combination, is in view of the effective ingredient of curcumin can play collaborative and assosting effect mutually with the biologic activity of VE and VC.VE is fat-soluble antioxidant, and VC is water miscible antioxidant, effectively can protect the effective ingredient in curcumin and curcumin extraction both above, suppresses the aerial oxidation Decomposition of curcumin.Triple combination achieves noticeable achievement in the treatment chronic gastritis improving curcumin and blood fat reducing; And the original relieving the exterior syndrome by diaphoresis function of curcumin is further strengthened, the health-care effect of this soft capsule is further expanded.
The present invention has the following advantages and effect relative to prior art tool:
The soft capsule that is principal agent composition with VE, VC and curcumin of the present invention, VC is water miscible antioxidant, and VE is fat-soluble antioxidant.Both antioxidations, can available protecting curcumin, suppresses the aerial oxidation Decomposition of curcumin, effectively can suppress the volatilization of curcumin volatile oil.Add before and after VC and VE, the assay of curcumin is known, and before the content of curcumin after interpolation comparatively adds, (in every hectogram) improves 43%; The content of curcumin volatile oil improves 34%; Illustrate that VE and VC prevents the oxidation Decomposition of curcumin effectively.
The soft capsule that is principal agent composition with VE, VC and curcumin of the present invention, the original relieving the exterior syndrome by diaphoresis function of curcumin is further strengthened, the patient of anemofrigid cold takes this capsule, the course of disease can be made to shorten 44.8%, and " flu " symptom of patient obviously alleviates.
The soft capsule that is principal agent composition with VE, VC and curcumin of the present invention, is enhanced about more than once repairing the effect in the mucomembranous defect that chronic gastritis causes; In the symptoms such as alleviation climacteric fear of cold, agitation, effect is remarkable; In blood fat reducing and cholesterol reducing, the medicine of this soft capsule and blood fat reducing plays synergism, makes effective percentage improve 37.6%, and presents the effect effectively controlling body weight.
The soft capsule that is principal agent composition with VE, VC and curcumin of the present invention.Its dosage form has plurality of advantages: 1. cover the pungent of curcumin and wait abnormal flavour, change and make groups of people be difficult to the problem taken.2. dosage is accurate relatively, and degree of accuracy is higher, can reach milligram/grain metering.3. the bioavailability of medicine and medicine stability are all improved.The person that takes soft capsule in test, on average peaks at 1.5h blood level, the person that takes tablet, and on average just peak at 2.5h blood level, the dose of curcumin can keep constant, can observe the effect that different crowd is taken better.4. curcumin is unstable in atmosphere easily decomposes, and is prepared into soft capsule, effectively by wet and oxygen, light in atmosphere effect, can improve stability by protection medicine.5. curcumin and extract thereof are all insoluble in water, add vitamin E and belong to as liposoluble substance, not easily make the medicine of ball, tablet, can be made into soft capsule.Meanwhile, reduce the loss that in storage and transportation, curcumin decomposes, make the effective content of curcumin improve 66%.Due to the raising of the content of curcumin, make the corresponding raising 52% of the absorption quality of curcumin.
The present invention with the addition of flavoring agent equally in soft capsule, makes the crowd of Reflux exophagitis, is also unlikely to the stimulation being subject to pungent, bitterness when reflux.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited only to this.
Embodiment 1
A kind of vitamin E, vitamin C and curcumin are soft capsule constituent and the preparation method of principal agent composition:
Active component forms according to percentage by weight (0.5g/ grain): curcumin: 5%; Curcumin extraction: 70%; VE:8.5%; VC:16.5%, above composition adds soft capsule preparation adjuvant, makes soft capsule.
Embodiment 2
A kind of VE, VC and curcumin are soft capsule constituent and the preparation method of principal agent composition:
Active component forms according to percentage by weight (0.5g/ grain): curcumin: 70%; Curcumin extraction: 5%; VE:8.5%; VC:16.5%, above composition adds soft capsule preparation adjuvant, makes soft capsule.
Embodiment 3
A kind of VE, VC and curcumin are soft capsule constituent and the preparation method of principal agent composition:
Active component forms according to percentage by weight (0.5g/ grain): curcumin: 40%; Curcumin extraction: 38.5%; VE:1.5%; VC:20%, above composition adds soft capsule preparation adjuvant, makes soft capsule.
Embodiment 4
A kind of VE, VC and curcumin are soft capsule constituent and the preparation method of principal agent composition:
Active component forms according to percentage by weight (0.5g/ grain): curcumin: 40%; Curcumin extraction: 50%; VE:5%; VC:5%, above composition adds soft capsule preparation adjuvant, makes soft capsule.
Embodiment 5
Soft capsule obtained by embodiment 1-4, carry out Double-blind randomized clinical trial by the patient of anemofrigid cold, experimental program is:
(1) only conventional therapy is carried out;
(2) on the basis of (1), the soft capsule taken obtained by embodiment 1 is increased, every day 2 times, each 2;
(3) on the basis of (1), the soft capsule taken obtained by embodiment 2 is increased, every day 2 times, each 2;
(4) on the basis of (1), the soft capsule taken obtained by embodiment 3 is increased, every day 2 times, each 2;
(5) on the basis of (1), the soft capsule taken obtained by embodiment 4 is increased, every day 2 times, each 2;
Result of the test shows, scheme 2 shortens 44.8% compared with the course of disease of scheme 1; Scheme 3 shortens 43.6% compared with the course of disease of scheme 1; Scheme 4 comparatively scheme 1 shortens 45.2%; Scheme 5 shortens 44.3% compared with the course of disease of scheme 1; The above results shows the soft capsule obtained by embodiment 1-4, and its effective percentage is close, and curative effect is substantially identical.
Example 6
Soft capsule obtained by embodiment 1-4, carry out Double-blind randomized clinical trial by the patient of anemofrigid cold, testing program is:
(1) only conventional therapy is carried out;
(2) on the basis of (1), the soft capsule taken obtained by embodiment 1-4 is increased, every day 2 times, each 2;
(3) on the basis of (1), increase and take VC, (use amount is equal with VC in (2));
(4) on the basis of (1), increase and take curcumin; (use amount is equal with curcumin in (2));
(3) on the basis of (1), increase and take VE, (use amount is equal with VE in (2));
Result of the test is: the therapeutic effect of scheme 2 is best, and scheme 2 shortens 44.8% compared with the course of disease of scheme 1, and patients symptomatic alleviates significantly; Scheme 2 shortens 22.7% compared with the course of disease of scheme 3; Scheme 2 shortens 8.1% compared with the course of disease of scheme 4, and patients symptomatic alleviates; Scheme 2 shortens 32.2% compared with the course of disease of scheme 5.The above results shows, the soft capsule that embodiment 1-4 is obtained, and in the process of auxiliary treatment anemofrigid cold, effective percentage is close, and curative effect is substantially identical.
Embodiment 7
Soft capsule obtained by embodiment 1-4, carry out Double-blind randomized clinical trial by the patient of chronic gastritis, experimental program is:
(1) only conventional therapy is carried out;
(2) on the basis of (1), the soft capsule taken obtained by embodiment 1 is increased, every day 2 times, each 2;
(3) on the basis of (1), the soft capsule taken obtained by embodiment 2 is increased, every day 2 times, each 2;
(4) on the basis of (1), the soft capsule taken obtained by embodiment 3 is increased, every day 2 times, each 2;
(5) on the basis of (1), the soft capsule taken obtained by embodiment 4 is increased, every day 2 times, each 2;
Result of the test shows, scheme 2 shortens 41.6% compared with the course of disease of scheme 1; Scheme 3 shortens 42.2% compared with the course of disease of scheme 1; Scheme 4 comparatively scheme 1 shortens 41.7%; Scheme 5 shortens 41.4% compared with the course of disease of scheme 1; The above results shows the soft capsule obtained by embodiment 1-4, and in the process of auxiliary treatment chronic gastritis, effective percentage is close, and curative effect is substantially identical.
Embodiment 8
Soft capsule obtained by embodiment 1-4, carry out Double-blind randomized clinical trial by the patient of chronic gastritis, testing program is:
(1) only conventional therapy is carried out;
(2) on the basis of (1), the soft capsule taken obtained by embodiment 1-4 is increased, every day 2 times, each 2;
(3) on the basis of (1), increase and take VE, (use amount is equal with VE in (2));
(4) on the basis of (1), increase and take curcumin; (use amount is equal with curcumin in (2));
(5) on the basis of (1), increase and take VC, (use amount is equal with VC in (2));
Result of the test is: the therapeutic effect of scheme 2 is best, and scheme 2 shortens 41.6% compared with the course of disease of scheme 1, and gastroscopic observation cell migration is all right, and the symptom of patient's stomach discomfort significantly alleviates.Scheme 2 shortens 11.9% compared with the course of disease of scheme 3, and patients symptomatic alleviates.Scheme 2 shortens 21.2% compared with the course of disease of scheme 4, and patients symptomatic alleviates.Scheme 2 shortens 14.2% compared with the course of disease of scheme 5, and patients symptomatic alleviates.Above-mentioned result of the test shows, the adjuvant treatment effect of soft capsule of the present invention to chronic gastritis is remarkable.
Embodiment 9
Soft capsule obtained by embodiment 1-4, carry out Double-blind randomized clinical trial by the patient of hyperlipidemia, experimental program is:
(1) only conventional therapy is carried out;
(2) on the basis of (1), the soft capsule taken obtained by embodiment 1 is increased, every day 2 times, each 2;
(3) on the basis of (1), the soft capsule taken obtained by embodiment 2 is increased, every day 2 times, each 2;
(4) on the basis of (1), the soft capsule taken obtained by embodiment 3 is increased, every day 2 times, each 2;
(5) on the basis of (1), the soft capsule taken obtained by embodiment 4 is increased, every day 2 times, each 2;
Result of the test shows, scheme 2 shortens 37.5% compared with the course of disease of scheme 1; Scheme 3 shortens 37.1% compared with the course of disease of scheme 1; Scheme 4 comparatively scheme 1 shortens 36.8%; Scheme 5 shortens 37.7% compared with the course of disease of scheme 1; The above results shows the soft capsule obtained by embodiment 1-4, and in the process of auxiliary treatment hyperlipidemia, effective percentage is close, and curative effect is substantially identical.
Embodiment 10
Have the soft capsule obtained by embodiment 1-4, carry out Double-blind randomized clinical trial by the patient of hyperlipidemia, experimental program is:
(1) medicine of conventional blood fat reducing is taken
(2) on the basis of (1), the soft capsule obtained by embodiment 1-4 is taken, every day 2 times, each 2
(3) on the basis of (1), VC is taken, (use amount is equal with VC in (2));
(4) on the basis of (1), VE is taken, (use amount is equal with VE in (2)); (5) on the basis of (1), curcumin (use amount is equal with curcumin in (2)) is taken, every day 2 times, each 2;
After six months, statistical results are: the therapeutic effect of scheme 2 is best.Scheme 2 declines 37.6% compared with the patients with lipid of scheme 1, the general status of patient, and as dizziness, spiritlessness and weakness, insomnia forgetfulness, numb limbs and tense tendons, uncomfortable in chest, the improvement of cardio palmus shape is remarkable.Scheme 2 declines 21.7% compared with the patients with lipid of scheme 3; Scheme 2 declines 18.1% compared with the patients with lipid of scheme 4; Scheme 2 declines 17.3% compared with the patients with lipid of scheme 5; Above-mentioned result of the test shows, the present invention can play synergism with the medicine of blood fat reducing.
Above-described embodiment is the better matched combined of each composition of the present invention; but embodiment of the present invention are not restricted to the described embodiments; the amendment made under other any does not deviate from spirit of the present invention and principle, substitute, combine, simplify and all should be considered as equivalent replacement mode, be included within protection scope of the present invention.
Claims (2)
1., with vitamin E, vitamin C and the curcumin composition soft for principal agent composition, it is characterized in that its active component mass percent is curcumin extraction: 5-70%, curcumin: 5-70%, vitamin C: 5-20%, vitamin E: 1.5-8.5%; Add soft capsule preparation adjuvant, make soft capsule and get final product.
2. soft capsule according to claim 1, it is characterized in that the specification of described tablet is 0.5g/ grain, namely wherein the content sum of active component vitamin E, vitamin C, curcumin extraction, curcumin is 0.5g/ grain.
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