CN101062097A - Compound for improving and treating fatty liver disease - Google Patents
Compound for improving and treating fatty liver disease Download PDFInfo
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- CN101062097A CN101062097A CNA2007102008031A CN200710200803A CN101062097A CN 101062097 A CN101062097 A CN 101062097A CN A2007102008031 A CNA2007102008031 A CN A2007102008031A CN 200710200803 A CN200710200803 A CN 200710200803A CN 101062097 A CN101062097 A CN 101062097A
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Abstract
The invention relates to a traditional Chinese medicinal composition for preventing and treating fatty liver, wherein the composition comprises Monascus color extract, schisandra fruit extract and Silybum marianum extract.
Description
Technical field
The invention belongs to field of medicaments, particularly relate to a kind of improvement and lipotropic compositions.
Background technology
Fat accounts for 3%～5% of liver gross weight under the normal condition.1/10 or the histology that surpass liver weight when fat content are fatty liver when upward hepatocyte fatties more than half become.Its pathogenesis is not clear and definite fully as yet so far, it is generally acknowledged that the imbalance that hepatocyte is synthesized between triacylglycerol and the secretion very low density lipoprotein (VLDL) is the main cause that forms fatty liver, and this imbalance is because due to increase of hepatocyte lipogenesis or the oxidation minimizing.Change along with living habit and dietary structure, the enhancing of health care consciousness, the progress of detection means, the sickness rate and the recall rate of fatty liver increase gradually, become the common hidden danger of a serious harm human body health, the certain areas fatty liver has become the second largest hepatopathy that is only second to viral hepatitis.According to American-European scholar's statistics, the pathogenesis of fatty liver rate accounts for 10%～24% general crowd, accounts for 57.5%～74% in the overweight people.In China, according to geographic part survey results such as Beijing, Shanghai and Nanjing, Hangzhou, Lianyun Harbour, Jiangsu, sickness rate does not wait between 5.2%～11.4%, and wherein the male is higher than the women, and age of onset has more and more littler trend.Significant be the incidence rate of discovering in non-alcoholic fatty liver disease (NAFL) hepatic fibrosis to be arranged up to 25%.Wherein 1.5%～8.0% patient can make progress and is hepatitis interstitialis chronica, and causes a series of severe complications, be considered to the latent cirrhotic commonly encountered diseases of source property because of.Therefore, lipotropism more and more causes people's attention.Present western medicine fatty liver or existence toxicity in various degree, or lipid-lowering effect is undesirable. and regular meeting's bounce-back affects the treatment after the drug withdrawal, so, be restricted aspect the fibrosis of its development of control and liver for a kind of like this chronic disease of fatty liver.The fatty liver traditional Chinese medical science does not have this name of disease, belongs to " gathering " categories such as " lump at the left hypochondrium " more, belongs to the disease of liver spleen, as " interior warp " institute cloud: " liver is long-pending, day lump at the left hypochondrium ".Think that this disease is to eat the delicious food savoury owing to having a liking for for a long time, insobriety or lying on bed for a long time sitting, the rich expectorant of body is full of, or internal injury caused by excess of seven emotions, it is improper to take good care of oneself, and makes spleen lose fortuneization, the liver failing to maintain the normal flow of QI, organism metabolic disorder, it is little that water paddy can not change spermatogenesis, poly-and be the wet expectorant that is, stasis of blood resistance liver network and form this disease.Chinese medicine fatty liver curative effect steadily, the advantage of multidirectional adjusting is arranged, more to the research of Chinese medicine decoction treatment fatty liver in recent years.Up to now, for the treatment of fatty liver, all do not finding satisfied fully therapeutic scheme aspect the traditional Chinese medical science and the doctor trained in Western medicine.
Summary of the invention
The object of the present invention is to provide a kind of improvement and lipotropic compositions, this compositions has blood lipid regulation, liver-protective effect, and toxic and side effects is little.
In a kind of improvement and lipotropic compositions involved in the present invention, contain Monas cuspurpureus Went extract, Fructus Schisandrae Chinensis extrat and Herba Silybi mariani extract.
Monas cuspurpureus Went extract is 0.02～20% in its weight percentage of lovastatin in the compositions, Fructus Schisandrae Chinensis extrat is 0.05～30% in its weight percentage of schisandrin B, and Herba Silybi mariani extract is 0.05～50% in its weight percentage of silymarin.
Monas cuspurpureus Went extract is 0.1～5% in the lovastatin weight percentage in the preferred composition, and Fructus Schisandrae Chinensis extrat is 0.2～10% in the schisandrin B weight percentage, and Herba Silybi mariani extract is 0.2～20% in the silymarin weight percentage.
Further Monas cuspurpureus Went extract is 1% in the lovastatin weight percentage in the preferred composition, and Fructus Schisandrae Chinensis extrat is 2% in the schisandrin B weight percentage, and Herba Silybi mariani extract is 10% in the silymarin weight percentage.
Described Monas cuspurpureus Went extract is a main active with the lovastatin, and lovastatin accounts for 0.4～99% by weight percentage in the Monas cuspurpureus Went extract; Described Fructus Schisandrae Chinensis extrat is a main active with the schisandrin B, and schisandrin B accounts for 5～99% by weight percentage in the Fructus Schisandrae Chinensis extrat; Described Herba Silybi mariani extract is a main active with the silymarin, and silymarin accounts for 40～99% by weight percentage in the Herba Silybi mariani extract.
Described compositions is made acceptable dosage form clinically with acceptable adjuvant medically.
The dosage form of described compositions can be tablet, capsule, granule, powder, pill, drop pill, mixture, injection and other clinical acceptable preparation.
The preparation of described compositions can be ordinary preparation, quick releasing formulation, sustained-release preparation and other clinical acceptable preparation.
Described compositions is improved and control fatty liver medicine and the application in accent fat liver-protecting health food in preparation.
The sweet temperature of Monas cuspurpureus Went is gone into hepatosplenomegaly intestinal warp, energy blood circulation promoting and blood stasis dispelling, strengthening the spleen to promote digestion.Monas cuspurpureus Went head sees principle of Correct Diet, claims its sweet in the mouth flat, nontoxic, and the effect of spleen invigorating, QI invigorating, warming middle-JIAO is arranged; " Bencao Jingshu " says that it helps digestion, spleen invigorating is identical with Massa Medicata Fermentata, and invigorates blood circulation and hinder, and is can with the Monas cuspurpureus Went; " Amplification on Materia Medica addendum " claims it to invigorate blood circulation to help digestion the spleen invigorating warming the stomach; " Chinese medicine dictionary " claims its energy blood circulation promoting and blood stasis dispelling, strengthening the spleen to promote digestion, treatment prolonged lochia, the stagnant stomachache of the stasis of blood, glutted, the red white dysentery of food stagnation and traumatic injury.Modern pharmacology confirms that Monas cuspurpureus Went can act on lipometabolic different link, as absorption by the exogenous cholesterol of interference, suppress the metabolism of endogenous cholesterol, be rich in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and multiple unsaturated fatty acid, TC and TG be can effectively reduce, and multiple essential amino acids and trace element in the human body contained.Effective ingredient lovastatin in the Monas cuspurpureus Went is used for the treatment of hyperlipidemia, is one of world's situation of selling well medicine.The effect of Monas cuspurpureus Went extract is better than lovastatin, and safety has no side effect.
Herba Silybi mariani hardship, cold have the effect of heat-clearing and toxic substances removing, nourishing the liver function of gallbladder promoting.Modern study shows to have stable liver plasma membrane, and the protection hepatocyte is without prejudice, and improves the effect of liver function, and serum cholesterol-lowering reduces the liver fat deposition, removes oxygen-derived free radicals in the body, to the effect of anti peroxidation of lipid and direct or indirect anti-hepatic fibrosis.Effective ingredient in the Herba Silybi mariani is mainly flavonoid, wherein mainly contains silibinin, Isosilybin, silidianin, Silychristin etc.According to modern pharmacological research; silymarin has the free radical resisting activity, removes active oxygen and antagonism lipid oxidation; suppress NO production; suppress 5 '-lipoxygenase; the protection liver plasma membrane; promote that hepatocyte is repaired, regeneration, many-sided pharmacological activity such as immunoregulation effect, the corresponding link that these effects can prevent fatty liver to take place.At present the preparation of being made by Herba Silybi mariani extract is widely used in the acute, chronic hepatitis that a variety of causes causes and the treatment of liver cirrhosis, and the control fatty liver is more satisfactory, determined curative effect, and toxic and side effects is little.
Trimethyl gallic acid, sweet, temperature is returned lung, the heart, kidney channel, has the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming.Chinese Magnoliavine Fruit alcohol extract and deoxyschizandrin, second element, third element, pure first, pure second, ester first, ester the second grade have obvious protective effect to the animal liver cell damage that chemical toxicant causes, can suppress transaminase's release, make the active reduction of ALT.Can obvious inducing mouse and rat liver microsomes cytochrome P-450 activity.Can promote liver glycogen heteroplasia and liver glycogen to decompose.Increase the liver detoxification ability.The carbon monoxide that Fructus Schisandrae Chinensis generates after the hepatomicrosome metabolic conversion CCl4 and in metabolic process the consumption to NADPH also inhibitory action can be arranged.Fructus Schisandrae Chinensis also has enhance immunity, slow down aging, antioxidation, effects such as antitumor.
Fatty liver is owing to liver inner lipid too high levels, thereby causes the disease of abnormal liver function.So most patient's hyperlipemia and abnormal liver function are also deposited.Heavy dose of use lipid-regulation medicine as Statins, the special class of shellfish, because lipid-regulation medicine is thanked at liver mostly, raises so can cause slight transaminase, heavy dose of life-time service lipid-regulation medicine, and the transaminase certainly will further raise.Though it is normal that the result is a blood fat, liver function further worsens.And many lipid-regulation medicines may order about blood fat and more concentrate on liver metabolism, impel accumulation of lipid on the contrary and damage liver function.So in the treatment of fatty liver, answer the coupling hepatic when using fat regulation medicine.In the compositions provided by the present invention, contain Monas cuspurpureus Went extract, Fructus Schisandrae Chinensis extrat, Herba Silybi mariani extract,, utilize the synergism of three kinds of compositions, make this compositions have the effect of blood lipid regulation hepatoprotective by selection to the reasonable science of its consumption.Said composition is had in mind from transferring fat and hepatoprotective two aspects at the pathogenesis of fatty liver, and side effect is low, and the adverse consequencess such as hepatic injury of having avoided independent application lipid-regulation medicine to cause have strengthened lipid-lowering effect again, can be used for improving and the control fatty liver.The beneficial effect of compositions of the present invention is confirmed by pharmacodynamic experiment and patient's result on trial.
The specific embodiment
Below in conjunction with specific embodiment improvement and lipotropic compositions among the present invention are further described.
Embodiment 1
Improve and lipotropic compositions, it is to be made by following weight percentages:
Monas cuspurpureus Went extract (in lovastatin) 0.02,0.1,0.5,1,2,5,10 or 20
Fructus Schisandrae Chinensis extrat (in schisandrin B) 0.05,0.2,1,2,5,10,15 or 30
Herba Silybi mariani extract (in silymarin) 0.05,0.2,5,10,15,20,30 or 50
Method for making 1: get above-mentioned raw materials and be ground into fine powder,, make tablet, capsule or granule with auxiliary materials and mixing.
Method for making 2: get above-mentioned raw materials and be ground into fine powder, other gets PFG4000 heating melting, adds above-mentioned fine powder, stirs evenly, and pulverizes after the condensation, adds auxiliary materials and mixing, makes tablet, capsule or granule.
Method for making 3: get above-mentioned raw materials and be ground into fine powder, other gets PEG heating melting, adds above-mentioned fine powder, stirs evenly, and splashes in the condensed fluid, makes drop pill.
The inventory of the listed Monas cuspurpureus Went extract among this embodiment is the inventory in lovastatin, and actual feeding intake converted corresponding inventory according to the content of lovastatin in the used Monas cuspurpureus Went extract.The amount that used Monas cuspurpureus Went extract contains lovastatin during the throwing amount can be arbitrary content of 0.4～99%.
The inventory of the listed Fructus Schisandrae Chinensis extrat among this embodiment is the inventory in schisandrin B, and actual feeding intake converted corresponding inventory according to the content of schisandrin B in the used Fructus Schisandrae Chinensis extrat.The amount that used Fructus Schisandrae Chinensis extrat contains schisandrin B during the throwing amount can be arbitrary content of 0.5～99%.
The inventory of the listed Herba Silybi mariani extract among this embodiment is the inventory in silymarin, and actual feeding intake converted corresponding inventory according to the content of silymarin in the used Herba Silybi mariani extract.The moisture amount that flies silibin of used Herba Silybi mariani extract can be arbitrary content of 20～99% during the throwing amount.
Also can adopt other routine fashion to make acceptable clinically other any dosage form.
Embodiment 2
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 4%) 125g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 9%) 111g
Herba Silybi mariani extract (silymarin content is 80%) 62.5g
Method for making: get above-mentioned raw materials and be ground into fine powder, with encapsulated behind the starch 201.5g mixing, every dress 0.25g.
Using method is: oral, and each 2, every day 2～3 times.
Embodiment 3
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 1%) 250g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 15%) 65g
Herba Silybi mariani extract (silymarin content is 80%) 125g
Method for making: get above-mentioned raw materials and be ground into fine powder, with encapsulated behind the starch 60g mixing, every dress 0.25g.
Using method is: oral, and each 2, every day 2～3 times.
Embodiment 4
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 8%) 62.5g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 50%) 20g
Herba Silybi mariani extract (silymarin content is 85%) 94g
Method for making: get above-mentioned raw materials and be ground into fine powder, get 323.5gPFG4000 heating melting, add above-mentioned fine powder, stir evenly, pulverize after the condensation, incapsulate, every dress 0.25g.
Using method is: oral, and each 2, every day 2～3 times.
Embodiment 5
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 30%) 16.7g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 10%) 100g
Herba Silybi mariani extract (silymarin content is 60%) 133.3g
Method for making: get above-mentioned raw materials and be ground into fine powder, get 250gPFG4000 heating melting, add above-mentioned fine powder, stir evenly, pulverize after the condensation, incapsulate, every dress 0.25g.
Using method is: oral, and each 2, every day 2～3 times.
Embodiment 6
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 50%) 5g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 30%) 16.7g
Herba Silybi mariani extract (silymarin content is 90%) 27.8g
Method for making: get above-mentioned raw materials and be ground into fine powder, get 200.5gPFG4000 heating melting, add above-mentioned fine powder, stir evenly, pulverize after the condensation, incapsulate, every dress 0.25g.
Using method is: oral, and each 1, every day 2～3 times.
Embodiment 7
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 60%) 8.3g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 60%) 16.7g
Herba Silybi mariani extract (silymarin content is 95%) 84.2g
Method for making: get above-mentioned raw materials and be ground into fine powder, with encapsulated behind the starch 140.8g mixing, every dress 0.25g.
Using method is: oral, and each 1, every day 2～3 times.
Embodiment 8
Improve and lipotropic compositions, it is to be made by the following weight proportion raw material:
Monas cuspurpureus Went extract (lovastatin content is 90%) 5.5g
Fructus Schisandrae Chinensis extrat (schisandrin B content is 90%) 11.1g
Herba Silybi mariani extract (silymarin content is 95%) 84.2g
Method for making: get above-mentioned raw materials and be ground into fine powder,, granulate with starch 146g mixing, with micropowder silica gel 2.5g, magnesium stearate 0.75g mixing, compacting is in blocks, every heavy 0.25g.
Using method is: oral, and each 1, every day 2～3 times.
Claims (8)
1. an improvement and lipotropic compositions is characterized in that, contain Monas cuspurpureus Went extract, Fructus Schisandrae Chinensis extrat and Herba Silybi mariani extract.
2. compositions according to claim 1, it is characterized in that, described Monas cuspurpureus Went extract is 0.02～20% in its weight percentage of lovastatin, Fructus Schisandrae Chinensis extrat is 0.05～30% in its weight percentage of schisandrin B, and Herba Silybi mariani extract is 0.05～50% in its weight percentage of silymarin.
3. compositions according to claim 1, it is characterized in that, described Monas cuspurpureus Went extract is 0.1～5% in the lovastatin weight percentage, Fructus Schisandrae Chinensis extrat is 0.2～10% in the schisandrin B weight percentage, and Herba Silybi mariani extract is 0.2～20% in the silymarin weight percentage.
4. compositions according to claim 1, it is characterized in that, described Monas cuspurpureus Went extract is 1% in the lovastatin weight percentage, and Fructus Schisandrae Chinensis extrat is 2% in the schisandrin B weight percentage, and Herba Silybi mariani extract is 10% in the silymarin weight percentage.
5. according to claim 1,2,3,4 described compositionss, it is characterized in that described Monas cuspurpureus Went extract is main active with the lovastatin, lovastatin accounts for 0.4～99% by weight percentage in the Monas cuspurpureus Went extract; Described Fructus Schisandrae Chinensis extrat is a main active with the schisandrin B, and schisandrin B accounts for 5～99% by weight percentage in the Fructus Schisandrae Chinensis extrat; Described Herba Silybi mariani extract is a main active with the silymarin, and silymarin accounts for 40～99% by weight percentage in the Herba Silybi mariani extract.
6. according to claim 1,2,3,4 described compositionss, it is characterized in that described compositions is made any dosage form of acceptable clinically with acceptable adjuvant medically.
7. preparation according to claim 6 is characterized in that, said preparation can be ordinary preparation, quick releasing formulation, sustained-release preparation and other clinical acceptable preparation.
8. according to claim 1,2,3,4 described compositionss, improve and control fatty liver medicine and the application in accent fat liver-protecting health food in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007102008031A CN101062097B (en) | 2007-06-11 | 2007-06-11 | Compound for improving and treating fatty liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007102008031A CN101062097B (en) | 2007-06-11 | 2007-06-11 | Compound for improving and treating fatty liver |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101062097A true CN101062097A (en) | 2007-10-31 |
| CN101062097B CN101062097B (en) | 2011-05-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007102008031A Expired - Fee Related CN101062097B (en) | 2007-06-11 | 2007-06-11 | Compound for improving and treating fatty liver |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647845B (en) * | 2008-08-13 | 2011-11-30 | 张晶 | Natural product composition used for reducing blood fat and preparation method thereof |
| CN104435147A (en) * | 2014-12-08 | 2015-03-25 | 南京泛成生物化工有限公司 | Composition for preventing and treating non-alcoholic fatty liver disease and application thereof |
| CN105597014A (en) * | 2016-02-05 | 2016-05-25 | 黑龙江省宏望饲料有限责任公司 | Preparation for preventing and treating fatty liver of grass carp and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100591337C (en) * | 2005-03-23 | 2010-02-24 | 张帆 | Medicinal composition for preventing alcoholic liver damage |
| CN1301665C (en) * | 2005-05-18 | 2007-02-28 | 成刚 | Blood fat-regulating liver-protecting health food |
-
2007
- 2007-06-11 CN CN2007102008031A patent/CN101062097B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647845B (en) * | 2008-08-13 | 2011-11-30 | 张晶 | Natural product composition used for reducing blood fat and preparation method thereof |
| CN104435147A (en) * | 2014-12-08 | 2015-03-25 | 南京泛成生物化工有限公司 | Composition for preventing and treating non-alcoholic fatty liver disease and application thereof |
| CN105597014A (en) * | 2016-02-05 | 2016-05-25 | 黑龙江省宏望饲料有限责任公司 | Preparation for preventing and treating fatty liver of grass carp and preparation method thereof |
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| Publication number | Publication date |
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| CN101062097B (en) | 2011-05-04 |
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