CN106975069A - A kind of liver protecting composition and preparation method thereof - Google Patents

A kind of liver protecting composition and preparation method thereof Download PDF

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Publication number
CN106975069A
CN106975069A CN201710302191.0A CN201710302191A CN106975069A CN 106975069 A CN106975069 A CN 106975069A CN 201710302191 A CN201710302191 A CN 201710302191A CN 106975069 A CN106975069 A CN 106975069A
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parts
liver protecting
liver
composition according
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CN106975069B (en
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崔永日
潘淑勇
李香
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Qingdao Kang Maichen Biotechnology LLC
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Qingdao Kang Maichen Biotechnology LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The present invention relates to field of health care products, in particular to a kind of liver protecting composition and preparation method thereof.Count by weight, the composition includes following component：0.05~0.4 part of 1~5 part of hoveniae semoveniae semen, 0.5~4 part of the root of kudzu vine, 0.5~4 part of the fruit of Chinese wolfberry, 0.1~3 part of Poria cocos, 0.1~3 part of corn oligopeptide powder, 0.5~1 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.Described composition has liver-protective effect, without obvious toxic side effect, and has quick Dealcoholic sobering-up function concurrently.

Description

A kind of liver protecting composition and preparation method thereof
Technical field
The present invention relates to field of health care products, in particular to a kind of liver protecting composition and preparation method thereof.
Background technology
Liver is an organ based on metabolism in body, and plays deoxidation, storage glycogen inside body, divides The roles such as the synthesis of secreting property protein.Meanwhile, liver to ex vivo and external for example various medicines of many non-nutritive substances, Poisonous substance and in vivo some metabolites, with biotransformation, are thoroughly decomposed them or with original shape by metabolism Excrete, this effect is also referred to as " function of detoxification ".
The living environment and mode of modern are highly detrimental to the health of liver, and it is homely food to stay up late, work overtime, take medicine, It is improper diet etc., the health of liver is all directly endangered, in recent years virus hepatitis, liver fibrosis, fatty liver, alcoholic liver The hepatopathys such as lesion, medicamentous liver lesion and liver cancer increasingly become the principal disease for threatening compatriots' health.Various hepatopathys and hepatopathy The characteristics of sustainable growth and rejuvenation is presented in early stage patient, and market demand one kind is easy to use, have no toxic side effect and eutherapeutic Health-care liver protecting product.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of liver protecting composition, described combination for above-mentioned technical problem Dirty effect is protected in thing tool liver protection, without obvious toxicity, also has quick Dealcoholic sobering-up function concurrently, and can mitigate drunk rear gasteremphraxis Nausea and vomiting, feel dizzy.
The liver protecting composition of the present invention, is counted by weight, including following component：
1~5 part of hoveniae semoveniae semen, 0.5~4 part of the root of kudzu vine, 0.5~4 part of the fruit of Chinese wolfberry, 0.1~3 part of Poria cocos, corn oligopeptide powder 0.1 0.05~0.4 part of~3 parts, 0.5~1 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
The second object of the present invention is the method that offer prepares the present composition.
In one embodiment, each raw material is crushed, mixed.
In one embodiment, method of the invention comprises the following steps：
(a) each starting material with water is decocted, obtains decocting liquid, or extracted with ethanol water, obtain extract solution；
(b) formulation needed for being prepared with the decocting liquid or the extract solution.
Compared with prior art, beneficial effects of the present invention are：
(1) good drug efficacy, pure Chinese medicine formula, without obvious toxicity；
(2) convenient to take with Chinese medicine preparation form medication, effect is good；
(3) it is not only to relieve the effect of alcohol, moreover it is possible to reaching long-term protect liver, the mesh of liver protection.
Brief description of the drawings
, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical scheme of the prior art The accompanying drawing used required in embodiment or description of the prior art is briefly described, it should be apparent that, in describing below Accompanying drawing is some embodiments of the present invention, for those of ordinary skill in the art, before creative work is not paid Put, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the experimental result of experimental example 1 of the present invention；
Fig. 2 is the experimental result of experimental example 2 of the present invention.
Embodiment
One aspect of the present invention is related to a kind of liver protecting composition, is mainly made up of following raw material：Hoveniae semoveniae semen, the root of kudzu vine, Chinese holly Matrimony vine, Poria cocos, corn oligopeptide powder, swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
Count by weight, including following component：
1~5 part of hoveniae semoveniae semen, 0.5~4 part of the root of kudzu vine, 0.5~4 part of the fruit of Chinese wolfberry, 0.1~3 part of Poria cocos, corn oligopeptide powder 0.1 0.05~0.4 part of~3 parts, 0.5~1 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
It is preferred that, liver protecting composition as described above is counted by weight, including following component：
2~4 parts of hoveniae semoveniae semen, 1~3.5 part of the root of kudzu vine, 1~3.5 part of the fruit of Chinese wolfberry, 0.5~2.5 part of Poria cocos, corn oligopeptide powder 0.1~0.3 part of 0.5~2.5 part, 0.6~0.9 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
It is preferred that, liver protecting composition as described above is counted by weight, including following component：
2.5~3.5 parts of hoveniae semoveniae semen, 1.5~3 parts of the root of kudzu vine, 1.5~3 parts of the fruit of Chinese wolfberry, 1~2 part of Poria cocos, corn oligopeptide powder 1 0.15~0.25 part of~2 parts, 0.7~0.8 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
It is preferred that, liver protecting composition as described above is counted by weight, including following component：
3 parts of hoveniae semoveniae semen, 2.7 parts of the root of kudzu vine, 2.7 parts of the fruit of Chinese wolfberry, 1.5 parts of Poria cocos, 1.5 parts of corn oligopeptide powder, swan-mussel polysaccharide 0.75 part and 0.2 part of FLOS CHRYSANTHEMI ALBA from Haizhou of China.
It is preferred that, liver protecting composition as described above is counted by weight, and the composition also includes dried thin mushroom 1 ~5 parts；More preferably 2~4 parts.
It is preferred that, liver protecting composition as described above is counted by weight, and the composition also includes ginger 0.05 ~0.4 part；More preferably 0.1~0.3 part.
First, raw material (component)
Hoveniae semoveniae semen also known as cockspur, honey raisin tree is being dried to for Rhamnaceae plant trifoliate orange Dulcis (Hovenia duleis Thunb.) Ripe seed, mild-natured, sweet acid is nontoxic, and its primary efficacy is reducing fever and causing diuresis, relieving restlessness of quenching the thirst, relieving alcoholism.For pyreticosis polydipsia, Hiccup, vomits, difficult urination, the symptom such as alcoholism.Claim in motherland's Medical monographs, hoveniae semoveniae semen is mild-natured, sweet acid, enters spleen, lung Two warps, cure mainly drunk, dysphoria with smothery sensation, thirsty, vomiting, difficulty in urination and defecation, have significant diuresis except wine poison effect, are that one kind is relieved the effect of alcohol good medicine. Modern medicine study shows that hoveniae semoveniae semen is containing glucose, fructose, potassium nitrate, peroxidase etc..Hoveniae semoveniae semen and its compound can be significantly The concentration of ethanol in blood is reduced, promotes the removing of ethanol, the excessive free radicals produced in vivo after drinking are eliminated, peroxidating is hindered The formation of lipid, so as to mitigate damage of the ethanol to hepatic tissue, it is to avoid various metabolic disorders caused by alcoholism, induction it is each Plant disease.In addition, trifoliate orange Ju or digestion human body cross the health fruit of fattiness, often eating can be with defatting beauty.
The root of kudzu vine is the dry root of the perennial defoliation liana Pueraria lobota of pulse family (Pueraria lobata (ffilld) Ohw1.), Belong to Ministry of Public Health's announcement is both food and the article of medicine.《Bencao Shiyi》Call its " relieving alcoholism ".Modern study shows, Pueraria lobota Root contains a variety of mineral matters needed by human, amino acid, vitamin and flavones etc., dynamic with treatment cardiovascular and cerebrovascular disease, prevention The multiple pharmacological effects such as arteries and veins hardening, anti-oxidant, Antialcoholic liver-protecting.
The fruit of Chinese wolfberry is the dry mature fruit of plant of Solanaceae lycium barbarum (Lycuim barb arum L), as traditional Integration of drinking and medicinal herbs material, is the traditional rare traditional Chinese medicine of China, " red treasured " laudatory title is have, rich in plant polyose, protein, vitamin Etc. nutritional ingredient, the effect of with " nourishing yin and supplementing blood, benefiting shrewd head ", it has nourishing liver and kidney, benefiting shrewd head, blood-nourishing, and enhancing is exempted from Epidemic disease power etc. is acted on.
Poria cocos alias Fu spirits, put down, sweet, light, the thoughts of returning home, spleen, kidney channel.Clearing damp and promoting diuresis, spleen-benefiting mind-tranquilizing.Chemical composition：Containing Poria cocos Sugar, pachymic acid, protein, fat, lecithin, histidine, choline, ergosterol and sylvite etc..Belong to integration of drinking and medicinal herbs kind, have There is spleen-benefiting mind-tranquilizing.
Maize oligopeptide is the small molecule that the zein extracted from wholefood corn is obtained by zymolysis technique Peptide material, contains the hydrophobic amino acids such as a high proportion of leucine, valine, alanine and branched-chain amino acid and neutral amino Acid, seldom containing basic amino acids such as lysines.This special acid composition so that maize oligopeptide has a variety of functions, Such as hypotensive, relieve the effect of alcohol, reduce serum cholesterol.
Swan-mussel polysaccharide (Hyriopsis cumingii polysacchride) is from Non-marine Bivalvess mollusk triangle A kind of white powder natural polysaccharide material obtained from extraction, purifying in the freshwater mussel meat of sail freshwater mussel.Its research is shown, freshwater mussel meat is more Sugar has obviously protective effect to stem cell injuries.
FLOS CHRYSANTHEMI ALBA from Haizhou of China is also known as camomile, is the traditional cultivation medicinal plant of China.Proved through modern pharmacology：It has stop dysentery, disappeared Inflammation, improving eyesight, decompression, lipid-loweringing, the effect of salubrity.Its Central nervous has sedation, and has refrigeration function.
Mushroom is nutritious, delicious flavour, have " king in mushroom ", the laudatory title of " hats of vegetables ".It is sweet, it is mild-natured.Return liver, Stomach.Rich in branched-chain amino acid, hepatic injury is promoted to recover.Rich in lentinan, toxic chemical substance can be significantly reduced and resisted Infringement to liver.Rich in the nutritional ingredients such as B family vitamin, various trace elements, protect liver, liver protection.
Ginger is pungent, slightly warm in nature.Return lung, the spleen channel.For warm stomach, invigorating the spleen.
2nd, form and formulation
The composition that the present invention is provided can both be taken orally as medicine, can also be carried out as health food or beverage It is edible.
In one embodiment, composition of the invention is simple mixtures.Preparation process is by each raw material) it is simple mixed Conjunction.
In another embodiment, composition of the invention can be made into the form of Chinese patent drug.The formulation of Chinese patent drug Including but not limited to pill, powder, paste, tablet, granule (electuary), lozenge, capsule, aqua, tincture.
(1) pill
Pill is fine medicinal material powder or medicinal substances extract plus suitable binders or auxiliary material, the spherical or spherical solid being made Preparation, is one of Chinese patent drug most ancient formulation.It is divided into honeyed bolus, water-honeyed pill, the water-bindered pill, paste again according to the different pills of adhesive The types such as ball, condensed pill, micropill.
Preferably use condensed pill.Condensed pill is the decocting liquid or extract solution of whole medicinal materials or part medicinal material, with suitable auxiliary material Or fine drug powder adds suitable adhesive to be made.According to the difference of adhesive, concentration honeyed bolus, the concentration water-bindered pill, condensed water are divided into again Honeyed bolus.Condensed pill small volume, effective ingredient content is high, it is easy to takes, absorptance is dissolved in vivo slower.
In a preferred embodiment, by whole medicinal materials or the decocting liquid or extract solution of part medicinal material, with auxiliary material or medicine Thing fine powder adds adhesive that condensed pill is made.Preferably, by whole medicinal material decocting liquids or extract solution and adhesive and optional auxiliary material system Into condensed pill.
(2) powder
Powder is the powder preparation that one or more medicinal materials are mixed, and point oral powder and external pulvis, are China One of ancient times formulation.Powder therapeutic domain is wide, disperses fast after taking, and proves effective rapid, and with easy to make, easy to carry, section The advantages of saving medicinal material.
(3) paste
One of paste system pharmaceutical dosage form.Paste is the formulation that medicine is decocted to concentration with water or vegetable oil.Have for oral administration With two kinds of external application.Cream for oral administration generally shunts medicinal extract, medicinal extract, three kinds of soft extracts again；External plaster has two kinds of ointment, plaster.Wherein take orally Soft extracts and externally-applied ointment are common formulations in paste.Soft extracts for oral administration is called cream taste, is that medicine is added water to decoct, and filters dregs, plus Enter rock sugar, honey etc., be boiled into the cream of stiff, can long-term taking.It is usually used in chronic disease or person in poor health.The ointment of external application claims Ointment, general ointment is that beeswax is added in cotton seed oil or peanut oil, and heating fusing multiplies the fine drug powder that heat adds application, no Disconnected stirring, to be condensed.The readily volatilized medicine such as borneol, camphor, can add after ointment is cold and stir evenly.External-applied ointment is typically used In outer painting skin ulcer mange etc..
Present invention preferably uses soft extract, soft extract (cream taste) is that medicinal material is boiled with decocting, after concentration of removing slag, plus sweetener system Into semisolid preparation, also known as cream grow.Sweetener can be refined honey or sugar, xylitol, preferably xylitol.Soft extract, which has, to be absorbed It hurry up, concentration is high, small volume, be easy to preserve, the characteristics of can taking the standby long period.There is nourishing conditioning, it is slow for treating Venereal disease and weakness due to chronic disease person.
(4) tablet
Tablet is the Formulation that fine medicinal material powder or extract are suppressed with suitable auxiliary material or fine medicinal material powder, sub-dip cream Piece, semi-extract tablets and full powder piece etc., are one of conventional modern formulations.Tablet volume is small, and consumption is accurate, and easy disintegrating comes into force soon, And with production efficiency is high, cost is low, take and the convenient advantage of accumulating.Tablet is applied to various diseases.The present invention preferably makes Use medicinal extract piece.
(5) granule
Granule (electuary) be medicinal substances extract with suitable auxiliary material or with the granular formulations that fine medicinal material powder is made, be The novel form grown up on the basis of decoction, powder and syrup.There is graininess and block two kinds, be divided into soluble, suspension The different type such as property, effervescency and sugar-containing type, Sugarless type.Granule small volume, it is lightweight, take simple, it is in good taste, act on fast Speed, is used for the medicine of the effects such as help, cough-relieving, heat-clearing.
Preferably, prepared during preparation using water extract (decocting liquid).
(6) lozenge
Lozenge is fine medicinal material powder and suitable amount of adhesive such as honey, glutinous rice flour or regulation shape is made using the viscosity of medicinal material in itself The solid pharmaceutical preparation of shape.For oral administration or external application is available for, effect is taken orally and is approached with starched pill, external application applies affected part after using water or vinegar mill juice. Holding in the mouth or the eyes is used lozenge type mostly.
Preferably, lozenge of the invention is lozenge for oral administration.
(7) capsule
Capsule includes hard capsule and soft capsule.
Hard capsule be by appropriate medicinal substances extract, medicinal substances extract dosing powder or auxiliary material be made uniform powder or Grain, is filled in the formulation being made in hard shell capsules.It is mainly oral.Hard shell capsules outward appearance is neat and artistic, it is easy to swallow, and can cover medicine The bad odor of thing, disintegration is fast, good absorbing.Suitable for photaesthesia, unstable or meet wet, thermally labile medicine, or there is spy The medicine of different odor, or need the medicine of timing positioning release.Children, the medicine strong to gastric irritation should not be made Capsule.
Soft capsule is by oils or is closed in capsule material to liquid medicine of the capsule materials such as gelatin without dissolution or suspension The formulation being inside made.Feature is similar to hard shell capsules.Hard shell capsules and soft capsule are handled by proper method or with other medicinal high scores Sub- material processing, makes softgel shell not dissolve in gastric juice, but is disintegrated discharge active component in intestinal juice, is capsulae enterosolubilis.
Preferably, capsule of the invention is that the medicinal substances extract for obtaining decocting liquid or extract solution adds auxiliary material that uniform powder is made End or particle, are filled in the formulation being made in hard shell capsules.
(8) aqua
Aqua is the aqueous solution of Chinese medicine composition, and medicament is dispersed in water with lewis' acid state, medicament it is dense Degree is depending on the water solubility of active compound, and ordinary circumstance is its maxima solubility, is watered dilution when using again.In order that obtaining in medicine Active ingredient release it is complete, can be using the aqua prepared by method such as hot water is fried, fried number of times can for 1 time, 2 times or more Repeatedly.
(9) tincture
Tincture is that the ethanol of medicine normal concentration leaches or dissolved the supernatant liquid preparation being made, and can also use liquid extract Dilution is made.It is divided to for oral administration and two kinds of external application.Tincture is prepared without heating, and composition is purer, and active constituent content is high, and dosage is accurate Really, absorb rapid, be suitable for preparing the preparation containing volatile ingredient or thermo-labile component.Preferably, tincture of the invention is Tincture for oral administration.
3rd, purposes
One aspect of the present invention is related to purposes of the composition of the present invention in preparing for liver protecting medicine.
The Foods or drinkses containing composition as described above are also claimed in another aspect of the present invention.
The food includes snack, dessert, raw material (stock), soup, stew (stew), sauce or gravy etc..
4th, preparation method
Another aspect of the present invention is related to the preparation method of liver protecting composition.
1st, the preparation of simple mixtures
Above-mentioned raw materials can be simply mixed together, so as to prepare the simple mixtures of the present invention.
In one embodiment, the method for preparing said composition comprises the following steps：Each component is crushed, one is blended in Rise.
2nd, the preparation of Chinese patent drug
In one embodiment, the method for preparing the present composition comprises the following steps：
(a) above-mentioned raw materials are boiled with decocting, obtains decocting liquid, or extracted with ethanol water, obtain extract solution；
(b) formulation needed for being prepared with decocting liquid.
Formulation can be above-mentioned formulation, for example pill, powder, paste, tablet, granule (electuary), lozenge, capsule, Aqua or tincture.
It is of course also possible to take Chinese patent drug formulation.On the basis of above-mentioned decocting liquid dosage, Chinese patent drug formulation dose passes through Clinical trial in the art can be determined.
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, be The conventional products that can be obtained by commercially available purchase.
Embodiment 1
Hoveniae semoveniae semen 5g, root of kudzu vine 4g, fruit of Chinese wolfberry 0.5g, Poria cocos 3g, swan-mussel polysaccharide 1g and FLOS CHRYSANTHEMI ALBA from Haizhou of China 0.05g.
Add 1.5 liters of drinking water pots to boil 60 minutes, be then concentrated into paste, mix, be fabricated to corn oligopeptide powder 3g Ball.
Embodiment 2
Hoveniae semoveniae semen 2g, root of kudzu vine 3.5g, fruit of Chinese wolfberry 1g, Poria cocos 2.5g, corn oligopeptide powder 0.5g, swan-mussel polysaccharide 0.9g and FLOS CHRYSANTHEMI ALBA from Haizhou of China 0.1g.
Add 1.5 liters of drinking water pots to boil 60 minutes, then concentrate, add xylitol, soft extract is made.
Embodiment 3
Hoveniae semoveniae semen 4g, root of kudzu vine 3.5g, fruit of Chinese wolfberry 3.5g, Poria cocos 0.5g, corn oligopeptide powder 2.5g, swan-mussel polysaccharide 0.6g with And FLOS CHRYSANTHEMI ALBA from Haizhou of China 0.3g.
Add 1.5 liters of drinking water pots to boil 60 minutes, then concentrate, add dextrin mixing, suppress, dry, obtained tablet.
Embodiment 4
Hoveniae semoveniae semen 3.5g, root of kudzu vine 1.5g, fruit of Chinese wolfberry 1.5g, Poria cocos 2g, corn oligopeptide powder 1g, swan-mussel polysaccharide 0.8g and FLOS CHRYSANTHEMI ALBA from Haizhou of China 0.15g.
Add 1.5 liters of drinking water pots to boil 40 minutes, be concentrated into 100mL, produce aqua.
Embodiment 5
Hoveniae semoveniae semen 2.5g, root of kudzu vine 3g, fruit of Chinese wolfberry 3g, Poria cocos 1g, corn oligopeptide powder 2g, swan-mussel polysaccharide 0.7g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 0.25g and dried thin mushroom 5g.
Add 1.5 liters of drinking water pots to boil 40 minutes, be concentrated into 100mL, produce aqua.
Embodiment 6
Hoveniae semoveniae semen 3g, root of kudzu vine 2.7g, fruit of Chinese wolfberry 2.7g, Poria cocos 1.5g, corn oligopeptide powder 1.5g, swan-mussel polysaccharide 0.75g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 0.2g, dried thin mushroom 3g and ginger 0.2g.
Boil medicine in two times, add water 165ml for the first time, pot boiling 90min；Add water 125ml for the second time, pot boiling 60min, by 2 times Decocting liquid merges, and is concentrated into 30ml, produces aqua.
Experimental example 1
Composition aqua made from Example 6 is used as cell toxicity test：
Cell is used：Chang Cell, dosage is equivalent to 0~8 bottle/day.Under conditions of cell survival rate >=90% i.e. It is judged as nontoxicity.As a result as shown in table 1 and Fig. 1.
Table 1
As a result：Equivalent is taken under conditions of≤8 bottles/day, not show cytotoxicity.
Conclusion：Under conditions of normal bottle/day of dose 1~2, human body is had no toxic side effect.
Experimental example 2
Composition aqua is CCl made from Example 64Cause the Germicidal efficacy of acute liver：
60 mouse are randomly divided into 6 groups, Normal group 10, CCl4Model group 10, sample sets high, normal, basic each 10 Only, positive control (sunflower liver-protecting tablet) 10.Use olive oil CCl4Concentration is 1%, is noted according to 10ml/kg body weight abdominal cavity Penetrate.After gastric infusion 1 week, CCl4Injection 0.1%CCl in model group and sample sets mouse peritoneal4Oil solution modeling.Every after 18h Mouse takes blood with eye socket blood taking method, separates serum, and conventional method detection liver function index (ALT, AST) the results are shown in Table 2 and Fig. 2.
Table 2
Group Number of animals ALT(U/L) AST(U/L)
Blank group 10 33.90±10.90** 28.90±3.57**
Contrast groups 10 347.15±41.33** 126.07±14.71**
Model group 10 484.51±93.39 143.43±24.78
Small dose group 10 297.31±50.23** 100.07±15.33**
Middle dose group 10 249.35±48.56** 90.93±15.45**
Heavy dose of group 10 198.13±45.01** 82.90±10.75**
Positive group 10 234.55±52.01** 98.73±12.93**
Note：Compared with model group, * P ＜ 0.05, * * P ＜ 0.01.
Wherein, blank group is without the mouse handled by acute liver damage；
Contrast groups use publication number CN102960809A, publication date on March 13rd, 2013, priority date December 5 in 2012 The anti-fatigue beverage that relieves the effect of alcohol used in the embodiment 5 of day；
Model group is the mouse for handling but being handled without any liver protection by acute liver damage；
The drug concentration that small dose group is taken is 810mg/kg；
The drug concentration that middle dose group is taken is 1620mg/kg；
The taken drug concentration of heavy dose group is 3240mg/kg；
Positive group is to take the mouse of sunflower liver-protecting tablet, and dose is 560mg/kg.
Three dosage of this sample can reduce ALT vigor, be compared with model group, there is pole significant difference (P ＜ 0.01)；
Three dosage of this sample can reduce AST vigor, and three dosage groups are compared with model group, there is pole significant difference (P ＜ 0.01).Experimental result illustrates that this sample has significant protective effect to hepatic injury, with obvious hepatoprotective effect.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent The present invention is described in detail with reference to foregoing embodiments for pipe, but it will be understood by those within the art that：Its The technical scheme described in foregoing embodiments can still be modified, or to which part or all technical characteristic Carry out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention skill The scope of art scheme.

Claims (10)

1. a kind of liver protecting composition, it is characterised in that count by weight, including following component：
1~5 part of hoveniae semoveniae semen, 0.5~4 part of the root of kudzu vine, 0.5~4 part of the fruit of Chinese wolfberry, 0.1~3 part of Poria cocos, corn oligopeptide powder 0.1~3 0.05~0.4 part of part, 0.5~1 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
2. liver protecting composition according to claim 1, it is characterised in that count by weight, including following component：
2~4 parts of hoveniae semoveniae semen, 1~3.5 part of the root of kudzu vine, 1~3.5 part of the fruit of Chinese wolfberry, 0.5~2.5 part of Poria cocos, corn oligopeptide powder 0.5~ 0.1~0.3 part of 2.5 parts, 0.6~0.9 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
3. liver protecting composition according to claim 2, it is characterised in that count by weight, including following component：
2.5~3.5 parts of hoveniae semoveniae semen, 1.5~3 parts of the root of kudzu vine, 1.5~3 parts of the fruit of Chinese wolfberry, 1~2 part of Poria cocos, corn oligopeptide powder 1~2 0.15~0.25 part of part, 0.7~0.8 part of swan-mussel polysaccharide and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
4. liver protecting composition according to claim 3, it is characterised in that count by weight, including following component：
3 parts of hoveniae semoveniae semen, 2.7 parts of the root of kudzu vine, 2.7 parts of the fruit of Chinese wolfberry, 1.5 parts of Poria cocos, 1.5 parts of corn oligopeptide powder, swan-mussel polysaccharide 0.75 0.2 part of part and FLOS CHRYSANTHEMI ALBA from Haizhou of China.
5. the liver protecting composition according to any one of Claims 1 to 4, it is characterised in that count by weight, described Composition also includes 1~5 part of dried thin mushroom.
6. the liver protecting composition according to any one of Claims 1 to 4, it is characterised in that count by weight, described Composition also includes 0.05~0.4 part of ginger.
7. liver protecting composition according to claim 1, it is characterised in that the formulation of the composition is pill, dissipated Agent, paste, tablet, granule, lozenge, capsule, aqua or tincture.
8. prepare the method for the composition according to any one of claim 1~7, it is characterised in that comprise the following steps：Will Each raw material is crushed, and is mixed.
9. prepare the method for the composition according to any one of claim 1~7, it is characterised in that comprise the following steps：
(a) each starting material with water is decocted, obtains decocting liquid, or extracted with ethanol water, obtain extract solution；
(b) formulation needed for being prepared with the decocting liquid or the extract solution.
10. the Foods or drinkses containing the composition described in any one of claim 1~7.
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CN107536016A (en) * 2017-09-11 2018-01-05 北京盛德元健康科技有限公司 A kind of cardioprotection and the nutraceutical for promoting liver health
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CN110448619A (en) * 2018-05-08 2019-11-15 沈阳离坎生物科技有限公司 It is a kind of to increase capacity for liquor and anti-intoxication composite preparation and preparation method thereof
CN108771089A (en) * 2018-06-06 2018-11-09 唐山肽景堂生物科技有限公司 A kind of solid beverage and preparation method thereof for adjusting liver diseases peptide compounding
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CN109432386A (en) * 2018-11-08 2019-03-08 武汉森澜生物科技有限公司 A kind of corn peptide combinations of relieving alcoholism and protecting liver and preparation method thereof
CN109380633A (en) * 2018-11-15 2019-02-26 湖北华龙西科生物科技有限公司 A kind of biological nano selenium small molecule water drink with function and preparation method thereof
CN112535230A (en) * 2020-11-12 2021-03-23 浙江英格莱制药有限公司 Herbaceous plant corn peptide vitamin sugar pill and preparation method thereof
CN114569686A (en) * 2022-04-01 2022-06-03 河北科技大学 Anti-alcohol composition, tablet with anti-alcohol effect and preparation method thereof

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