CN107536016B - A nutritional food for protecting heart and promoting liver health - Google Patents
A nutritional food for protecting heart and promoting liver health Download PDFInfo
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Abstract
The invention relates to a nutritional food for protecting heart and promoting liver health, which comprises the following raw materials in parts by weight: 1-20 parts of cordyceps militaris, 1-20 parts of agaricus blazei, 1-20 parts of birch mushroom, 1-15 parts of grifola frondosa, 1-20 parts of poria cocos, 5-15 parts of radix puerariae, 0.5-10 parts of saussurea involucrate culture (dry product), 0.5-10 parts of emblic leafflower fruit, 0.5-15 parts of earthworm protein, 0.5-10 parts of corn oligopeptide powder, 0.5-10 parts of chia seed and 0.5-10 parts of flaxseed. The nutritional food for protecting the heart and promoting the liver health has obvious curative effect and good clinical popularization value.
Description
Technical Field
The invention relates to a nutritional food for protecting heart and promoting liver health.
Background
In the modern society, the heart is overloaded due to the pressure of work, life and the like and the unscientific life style. If the body is in an extreme fatigue state or excessive smoking, drinking, or the heart suffers from certain diseases or is in a poor mood, etc., the heart is possibly injured by certain strong harmful factors to cause sudden stop, which causes great loss to the society and families. Cardiovascular diseases are the most common frequently encountered diseases, especially coronary heart disease. With the improvement of living standard, the improvement of dietary structure and the aging of population, the incidence of coronary heart disease is gradually increased. At present, most of the medicines for treating cardiovascular and cerebrovascular diseases in the market are western medicines, and have certain defects, such as easy generation of drug resistance, capability of causing arrhythmia as a medicine for treating arrhythmia, and even strong toxic and side effects of some medicines.
The liver is the largest and most important detoxifying organ of the human body and has a powerful defense detoxifying function on toxins produced by in vitro and body metabolism. The liver is the most sensitive and fragile. Insufficient sleep, obesity, hyperglycemia, excessive drinking, smoking, staying up all night, drug abuse and greasy food can aggravate the burden of the liver to damage the liver, and further the liver is changed into chronic liver injury and hepatitis, and finally the liver cancer is developed. Liver disease has become a "fierce" that seriously harms human health. Liver function is damaged, and can cause diseases such as diabetes, hypertension, heart disease and atherosclerosis accompanied by fat metabolism disorder.
Traditional Chinese medicine has enjoyable progress in the aspects of researches such as heart protection, liver health promotion and the like, but has certain defects, particularly shown in that single traditional Chinese medicine is more researched, and compound prescription is less researched; there are fewer comprehensive studies of the various mechanisms that work together.
Disclosure of Invention
The invention aims to provide a nutritional food for protecting heart and promoting liver health.
The technical scheme of the invention is as follows:
a nutritional food for protecting heart and promoting liver health comprises the following raw materials in parts by weight: 1-20 parts of cordyceps militaris, 1-20 parts of agaricus blazei, 1-20 parts of birch mushroom, 1-15 parts of grifola frondosa, 1-20 parts of poria cocos, 5-15 parts of radix puerariae, 0.5-10 parts of saussurea involucrate culture (dry product), 0.5-10 parts of emblic leafflower fruit, 0.5-15 parts of earthworm protein, 0.5-10 parts of corn oligopeptide powder, 0.5-10 parts of chia seed and 0.5-10 parts of flaxseed.
Preferably, the nutritional food for protecting the heart and promoting the liver health comprises the following raw materials in parts by weight: 5-15 parts of cordyceps militaris, 5-15 parts of agaricus blazei, 5-15 parts of birch mushroom, 2-10 parts of grifola frondosa, 5-15 parts of poria cocos, 3-10 parts of radix puerariae, 1-5 parts of saussurea involucrate culture (dry product), 1-5 parts of emblic leafflower fruit, 1-10 parts of earthworm protein, 1-5 parts of corn oligopeptide powder, 1-5 parts of chia seed and 1-5 parts of linseed.
Preferably, the nutritional food for protecting the heart and promoting the liver health comprises the following raw materials in parts by weight: 10 parts of cordyceps militaris, 8 parts of agaricus blazei, 8 parts of birch mushroom, 2 parts of grifola frondosa, 5 parts of poria cocos, 5 parts of radix puerariae, 2 parts of saussurea involucrate culture (dry product), 2 parts of emblic leafflower fruit, 3 parts of earthworm protein, 2 parts of corn oligopeptide powder, 3 parts of chia seed and 2 parts of linseed.
The raw materials of the invention are all available on the market.
The recommended eating amount of the nutritional food for protecting the heart and promoting the liver health is 10-60 g/day.
Generally, the health care effect can be achieved by continuously taking the medicine for 30 to 90 days.
The Cordyceps militaris is derived from artificially cultured fruiting body of Cordyceps militaris, belonging to Ascomycetes, Clavicipitaceae, and Cordyceps; the production process comprises inoculating Cordyceps militaris strain to culture medium, performing artificial culture, collecting Cordyceps militaris fruiting body, and oven drying. Cordyceps militaris is a new food raw material approved by the Ministry of health; see "bulletin about approval of 6 new food ingredients such as tagatose (No. 10 in 2014)".
Agaricus blazei, birch mushroom, grifola frondosa and poria cocos are both edible and medicinal fungi. Radix Puerariae is a medicinal and edible material.
The Saussurea involucrate culture of Saussurea involucrate is derived from callus of Saussurea involucrate (Saussurea involucrate) of Compositae, and the production process comprises: selecting saussurea involucrate in vitro tissue, taking callus formed by dedifferentiation as subculture seed, and subjecting to subculture under certain conditions to obtain block-shaped particles, or drying and pulverizing the particles to obtain powder. The saussurea involucrate culture is a new resource food approved by the ministry of health, and is referred to as "notice (No. 9 in 2010) that 5 kinds of articles such as approved golden camellia and inula flower (small black medicine) are new resource foods".
The fructus Phyllanthi is named as Dian olive, an unit, an laminated fruit, an Amanova fruit, an emblic fruit, an oil orange, which is an important plant used as both medicine and food.
Earthworm Protein Earth work Protein, the source is Eisenia foetida Savigny, the production technique includes: is prepared from earthworm through washing, hydrolyzing for autolysis, centrifugal separation, microfiltering, spray drying and packing. Earthworm protein is a new resource food approved by the Ministry of health, and is referred to as "bulletin of 7 kinds of articles approved as new resource food, such as tea seed oil, by Ministry of health (No. 18, 2009)".
Corn oligopeptide powder Corn oligopeptides powder, the source is Corn protein powder, the preparation method comprises: the corn protein powder is used as a raw material and is produced by processes of size mixing, protease enzymolysis, separation, filtration, spray drying and the like. Corn oligopeptide powder is a new resource food approved by the Ministry of health, and is referred to as a notice (No. 15 in 2010) about approval of 3 kinds of products such as sucrose polyester, corn oligopeptide powder and phosphatidylserine as new resource food.
Chia seed is derived from Salvia gordonii (Latin scientific name: Salvia hispanica L.) of Salvia of Labiatae, and edible part is seed. Chia seeds are a new food material approved by the Ministry of health; see "bulletin about approval of 6 new food ingredients such as tagatose (No. 10 in 2014)".
Flax seeds, also known as flax seeds, are seeds of an annual herbaceous plant flax and are an important medicinal and edible plant raw material.
Further, the protein content of the earthworm protein is more than or equal to 65 percent; for example, commercially available from jaba sieboldii biotechnology limited.
Furthermore, the protein content of the corn oligopeptide powder is more than or equal to 80 percent, and the peptide content is more than or equal to 75 percent; for example from the institute of Zhongshidu celebration (Shandong) Biotechnology, Inc.
If not indicated, all the raw materials of the invention are dry products.
The nutritional food for protecting heart and promoting liver health can be prepared by the conventional method; for example, the raw materials are mixed uniformly according to the proportion.
In order to better improve the nutrition and health care effects, the invention also provides a preparation method of the nutrition food for protecting the heart and promoting the liver health, which comprises the following steps:
1) weighing the required raw materials according to the proportion; mixing Cordyceps militaris, Agaricus blazei, birch mushroom, Grifola frondosa, Poria, radix Puerariae, herba Saussureae Involueratae culture, and fructus Phyllanthi, reflux-extracting with 5-15 times of 50-90% ethanol for 0.5-3.0 hr for 1-3 times, filtering, and collecting residue; mixing filtrates, and concentrating the filtrate to obtain extract I (with relative density of 1.10-1.30 at 30 deg.C);
2) adding 5-15 times of water into the filter residue obtained in the step 1), decocting for 1-3 times, each time for 0.5-2 hours, mixing decoctions, filtering, and concentrating the filtrate to obtain extract II (with relative density of 1.10-1.30 and temperature of 30 ℃);
3) mixing the obtained extract I and extract II, drying, and pulverizing; adding Lumbricus protein, semen Maydis oligopeptide powder, chia seed powder and semen Lini powder, and mixing.
Wherein the chia seed powder and the flaxseed powder are prepared by respectively crushing chia seeds and flaxseeds and sieving the crushed chia seeds and the flaxseeds with 100-mesh sieve of 150 meshes.
Preferably, the method for preparing the nutritional food for protecting the heart and promoting the liver health comprises the following steps:
1) weighing the required raw materials according to the proportion; mixing Cordyceps militaris, Agaricus blazei, birch mushroom, Grifola frondosa, Poria, radix Puerariae, herba Saussureae Involueratae culture, and fructus Phyllanthi, extracting with 70% -75% ethanol under reflux for 2 times, extracting with 8 times of ethanol for 3 hr for the 1 st time, extracting with 6 times of ethanol for 1 hr for the 2 nd time, filtering, and collecting the residue; mixing filtrates, and concentrating the filtrate to obtain extract I (with relative density of 1.10-1.30 at 30 deg.C);
2) decocting the filter residue obtained from the filter residue obtained in the step 1) with water for 2 times, adding 10 times of water by weight for 2 hours in the 1 st time, adding 8 times of water by weight for 1 hour in the 2 nd time, extracting for 1 hour, mixing decoctions, filtering, and concentrating the filtrate to obtain extract II (with relative density of 1.10-1.30, 30 deg.C);
3) mixing the obtained extract I and extract II, drying, and pulverizing; adding Lumbricus protein, semen Maydis oligopeptide powder, chia seed powder and semen Lini powder, and mixing.
Unless otherwise specified, the ethanol concentration in the invention refers to volume concentration.
Experiments prove that the process for extracting the raw materials furthest retains the active ingredients of the raw materials, the extracted active ingredients are most easily absorbed by human bodies, and the drug effect is enhanced, so that the problem that the drug effect is interfered by ineffective ingredients is solved.
In order to further improve the nutrition and health care efficacy, the invention also pulverizes the nutrition food for protecting the heart and promoting the liver health to 100-150 meshes.
The invention also provides a preparation containing the nutritional food for protecting heart and promoting liver health.
Furthermore, the preparation also contains auxiliary materials and/or additives used in the fields of food and health-care food; alternatively, the formulation further comprises a pharmaceutically acceptable carrier.
The preparation can be prepared by adding adjuvants, additives, carriers, etc. commonly used in food field, health food field or pharmacy, such as carrier, excipient, diluent, disintegrating agent, aromatic, colorant, sweetener, such as microcrystalline cellulose used as excipient and/or disintegrating agent.
The formulation may be in various conventional forms in the art, such as tablets (including chewable tablets), capsules, granules, tabletted candies, powders, and the like. For example, the nutritional food for protecting heart and promoting liver health can be directly filled into capsules to prepare capsules; or granulating, drying, and making into tablet.
The nutritional food and the preparation thereof for protecting the heart and promoting the liver health can be directly used as terminal food and can also be used as an ingredient of food or health-care food.
The invention also comprises the application of the nutritional food or the preparation thereof for protecting the heart and promoting the liver health in the preparation of food or health-care products or medicines.
The invention takes the traditional Chinese medicine theory as guidance, combines the modern medical research routine, carefully selects raw materials from the health preserving science perspective, scientifically combines the formula, achieves the health care effects of protecting the liver and promoting the health of the liver, and also has the health care effects of enhancing the human immunity, moistening the lung and strengthening the spleen, resisting oxidation, delaying senility, preventing hypertension, hyperglycemia, hyperlipidemia and the like.
The formula principle of the invention is as follows: the cordyceps militaris, the agaricus blazei, the birch mushroom, the grifola frondosa and the poria cocos are used as monarch drugs, the kudzu vine root, the saussurea involucrate culture and the emblic leafflower fruit are used as minister drugs, the chia seed, the flaxseed, the earthworm protein and the corn oligopeptide powder are used as assistant drugs, and the drugs are combined to play a role in strengthening the body resistance and consolidating the constitution, protecting the heart and protecting the liver, relieving depression and pain, tonifying qi and nourishing blood, promoting blood circulation to remove blood stasis and nourishing the heart and dredging the pulse, so that the comprehensive effects of protecting the heart and promoting the health of. The invention focuses on the integral conditioning and the internal conditioning of the human body, is elaborately developed by combining health preserving science, and can promote the health and the longevity of the human body.
The invention selects raw materials to regulate the five internal organs of a human body, and achieves the health-care effects of protecting the heart and promoting the health of the liver through comprehensive effects. Wherein heart qi is vigorous and heart blood is full by regulating heart; the liver stores blood, and regulates the liver to smooth qi and blood, so that the blood runs sufficiently, and the face is ruddy and glossy; the spleen is the acquired root and the source of qi and blood; the functions of the spleen and the stomach are healthy and healthy through regulating the spleen and the stomach, and qi and blood are vigorous; the lung governs the skin and hair, and regulates the lung to distribute qi, blood and body fluids throughout the body; kidneys store essence, and regulate kidneys to make kidney essence sufficient, so that when kidney qi is vigorous, the five internal organs function normally, qi and blood are vigorous, and the appearance is not weak.
The product of the invention has the advantages of mild property, mild action, stable drug effect, contribution to long-term administration and no adverse side effect.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
The Lumbricus protein is purchased from Jiayi Biotechnology GmbH of Zhuhai, and the content is more than or equal to 65%.
The corn oligopeptide powder is purchased from Zhongshidu qing (Shandong) biotechnology limited; the protein content is more than or equal to 80 percent, and the peptide content is more than or equal to 75 percent.
Example 1
A nutritional food for protecting heart and promoting liver health comprises the following raw materials in parts by weight: 10 parts of cordyceps militaris, 8 parts of agaricus blazei, 8 parts of birch mushroom, 2 parts of grifola frondosa, 5 parts of poria cocos, 5 parts of radix puerariae, 2 parts of saussurea involucrate culture (dry product), 2 parts of emblic leafflower fruit, 3 parts of earthworm protein, 2 parts of corn oligopeptide powder, 3 parts of chia seed and 2 parts of linseed.
The raw materials are mixed evenly according to the proportion and crushed to 100-150 meshes.
Example 2
A nutritional food for protecting heart and promoting liver health comprises the following raw materials in parts by weight: 15 parts of cordyceps militaris, 15 parts of agaricus blazei, 5 parts of birch mushroom, 2 parts of grifola frondosa, 15 parts of poria cocos, 10 parts of radix puerariae, 1 part of saussurea involucrate culture (dry product), 1 part of emblic leafflower fruit, 10 parts of earthworm protein, 1 part of corn oligopeptide powder, 5 parts of chia seed and 4 parts of flaxseed.
The raw materials are mixed evenly according to the proportion and crushed to 100-150 meshes.
Example 3
A nutritional food for protecting heart and promoting liver health comprises the following raw materials in parts by weight: 5 parts of cordyceps militaris, 15 parts of agaricus blazei, 5 parts of birch mushroom, 10 parts of grifola frondosa, 5 parts of poria cocos, 3 parts of radix puerariae, 5 parts of saussurea involucrate culture (dry product), 5 parts of phyllanthus emblica, 1 part of earthworm protein, 5 parts of corn oligopeptide powder, 1 part of chia seed and 2 parts of flaxseed.
The raw materials are mixed evenly according to the proportion and crushed to 100-150 meshes.
Example 4
A nutritional food for protecting heart and promoting liver health comprises the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 1 part of cordyceps militaris, 1 part of agaricus blazei, 1 part of birch mushroom, 1 part of grifola frondosa, 20 parts of poria cocos, 5 parts of radix puerariae, 0.5 part of saussurea involucrate culture (dry product), 0.5 part of emblic leafflower fruit, 0.5 part of earthworm protein, 0.5 part of corn oligopeptide powder, 0.5 part of chia seed and 1 part of linseed.
The raw materials are mixed evenly according to the proportion and crushed to 100-150 meshes.
Example 5
A nutritional food for protecting heart and promoting liver health comprises the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 20 parts of cordyceps militaris, 20 parts of agaricus blazei, 20 parts of birch mushroom, 15 parts of grifola frondosa, 1 part of poria cocos, 15 parts of radix puerariae, 10 parts of saussurea involucrate culture (dry product), 10 parts of emblic leafflower fruit, 15 parts of earthworm protein, 10 parts of corn oligopeptide powder, 10 parts of chia seed and 8 parts of linseed.
The raw materials are mixed evenly according to the proportion and crushed to 100-150 meshes.
Example 6
A nutritional food for protecting heart and promoting liver health, which has the same formulation as in example 1, is prepared by a method comprising the steps of:
1) weighing the required raw materials according to the proportion; mixing Cordyceps militaris, Agaricus blazei, birch mushroom, Grifola frondosa, Poria, radix Puerariae, herba Saussureae Involueratae culture, and fructus Phyllanthi, reflux-extracting with 70% ethanol for 2 times, extracting with 8 times of ethanol for 3 hr for the 1 st time, extracting with 6 times of ethanol for 1 hr for the 2 nd time, filtering, and collecting the residue; mixing filtrates, and concentrating the filtrate to obtain extract I (with relative density of 1.10 at 30 deg.C);
2) decocting the filter residue obtained from the filter residue obtained in the step 1) with water for 2 times, adding 10 times of water by weight for 2 hours in the 1 st time, adding 8 times of water by weight for 1 hour in the 2 nd time, extracting for 1 hour, mixing decoctions, filtering, and concentrating the filtrate to obtain extract II (with relative density of 1.10 at 30 ℃);
3) mixing the obtained extract I and extract II, drying, and pulverizing; adding Lumbricus protein, semen Maydis oligopeptide powder, chia seed powder and semen Lini powder, mixing, and pulverizing to 100 mesh powder of 150 mesh.
Example 7
A nutritional food for protecting heart and promoting liver health, which has the same formulation as in example 2, is prepared by a method comprising the steps of:
1) weighing the required raw materials according to the proportion; mixing Cordyceps militaris, Agaricus blazei, birch mushroom, Grifola frondosa, Poria, radix Puerariae, herba Saussureae Involueratae culture, and fructus Phyllanthi, reflux-extracting with 75% ethanol for 2 times, extracting with 10 times of ethanol for 2 hr for the 1 st time, extracting with 8 times of ethanol for 2 hr for the 2 nd time, filtering, and collecting the residue; mixing filtrates, and concentrating the filtrate to obtain extract I (with relative density of 1.10 at 30 deg.C);
2) decocting the filter residue obtained from the filter residue obtained in the step 1) with water for 3 times, adding 10 times of water by weight for 2 hours in the 1 st time, adding 8 times of water by weight for 1 hour in the 2 nd time, adding 5 times of water by weight for 0.5 hour in the 3 rd time, mixing decoctions, filtering, and concentrating the filtrate to obtain extract II (the relative density is 1.10, 30 ℃);
3) mixing the obtained extract I and extract II, drying, and pulverizing; adding Lumbricus protein, semen Maydis oligopeptide powder, chia seed powder and semen Lini powder, mixing, and pulverizing to 100 mesh powder of 150 mesh.
Example 8
A nutritional food for protecting heart and promoting liver health has the same formula as in example 3, and is prepared by the same method as in example 6.
Example 9
The nutritional food for protecting heart and promoting liver health of examples 1-8 was made into tablet, capsule, granule, tablet candy, and powder, respectively, by conventional method.
Comparative example 1
A nutritional food comprises the following raw materials: 3 parts of earthworm protein, 2 parts of corn oligopeptide powder, 3 parts of chia seed powder and 2 parts of flaxseed powder. The raw materials are mixed evenly according to the proportion and crushed to 100-150 meshes.
Comparative example 2
A nutritional food which differs from example 6 only in the following raw material ratios: 10 parts of cordyceps militaris, 8 parts of agaricus blazei, 8 parts of birch mushroom, 2 parts of grifola frondosa, 5 parts of poria cocos, 3 parts of earthworm protein, 2 parts of corn oligopeptide powder, 3 parts of chia seed and 2 parts of linseed.
Comparative example 3
A nutritional food which differs from example 6 only in the following raw material ratios: 5 parts of kudzu root, 2 parts of saussurea involucrate culture (dry product), 2 parts of emblic leafflower fruit, 3 parts of earthworm protein, 2 parts of corn oligopeptide powder, 3 parts of chia seed and 2 parts of flaxseed.
Experimental example 1 protective Effect test on non-alcoholic fatty liver disease
1) Experimental methods
SD rats, male, with a body weight of 220 + -20 g, are modeled by intragastric administration of high fat emulsion in combination with intraperitoneal injection of tetracycline. Except for the blank control group, 150mg/kg of tetracycline is intraperitoneally injected into the other groups on the 1 st day of molding, and 110mg/kg of tetracycline is intraperitoneally injected every 6 days for 1 time and 6 times. Except for blank group, each group was administered daily with high fat emulsion (formula: lard 20g, cholesterol 10g, fructose 5g, sucrose 5g, bile salt 1g, sodium glutamate 1g, propylene glycol 15ml, small amount of Tween 80, distilled water to constant volume of 100ml), dosage of 10 ml. kg-1·d-1. And (5) continuously perfusing the stomach with 8W of high fat emulsion.
After the model rats are adaptively fed for 1 week, the model rats are randomly divided into a blank control group, a model group and an experimental group, and the specific grouping conditions are as follows, wherein 10 rats are in each group. Gavage every afternoon, the doses were as follows:
example 6 group: the nutritional food for protecting heart and promoting liver health prepared in example 6 is administered by intragastric administration, and the dosage is 0.25 g/(kg.d);
example 7 group: the nutritional food for protecting heart and promoting liver health prepared in example 7 is administered by intragastric administration, and the dosage is 0.25 g/(kg.d);
comparative example 1 group: the nutritional food prepared in comparative example 1 was administered by gavage at 0.25 g/(kg.d);
comparative example 2 group: gavage the nutritional food prepared in example 2, 0.25 g/(kg.d);
comparative example 3 group: gavage the nutritional food prepared in example 3 to 0.25 g/(kg.d);
blank control group: intragastrically administering the same volume of distilled water;
model group: the gavage was given the same volume of distilled water.
2) Detecting the index
After the last gastric lavage, blood is taken from the abdominal main vein to determine biochemical indexes.
3) Results of the experiment
The blood biochemical index detection results are shown in table 1.
TABLE 1 blood biochemical index test results
TABLE 1 test results of blood biochemical indicators
Note: in comparison with the set of models,*p is less than 0.05; in comparison with the set of models,**P＜0.01；
in comparison with the group of comparative example 2,#p is less than 0.05; in comparison with the group of comparative example 2,##P＜0.01。
the test results show that the contents of the rat serum ALT, AST, total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in each administration group are significantly different from those in the model group, and the groups of example 6 and example 7 are also significantly different from those in the comparative example 2, which indicates that the heart-protecting and liver-health-promoting nutritional food of the invention achieves a synergistic effect on the prevention or treatment of the fatty liver of the rat.
The results of the liver index measurements are shown in Table 2.
TABLE 2
| Group of | Body weight (g) | Liver index (%) |
| Blank control group | 417±0.42 | 2.58±0.33 |
| Model set | 486±0.17 | 4.70±0.25△△ |
| EXAMPLE 6 group | 443±0.39 | 2.87±0.49**## |
| EXAMPLE 7 group | 451±0.21 | 3.05±0.60**## |
| Comparative example 1 group | 453±0.39 | 4.02±0.19△* |
| Comparative example 2 group | 445±0.37 | 3.79±0.27△* |
| Comparative example 3 group | 450±0.35 | 3.93±0.38△* |
Note: compared with the blank control group, the composition of the composition,△p is less than 0.05; compared with the blank control group, the composition of the composition,△△P＜0.01；
in comparison with the set of models,*p is less than 0.05; in comparison with the set of models,**P＜0.01；
in comparison with the group of comparative example 2,#p is less than 0.05; in comparison with the group of comparative example 2,##P＜0.01；
the experimental result shows that the liver index of the rats in the fatty liver model group has significant difference compared with that of a blank control group, and the liver index of the rats in each administration group has significant difference compared with that of the model group; the liver indexes of rats in the example 6 group and the example 7 group are very different from those of the model group and the comparative example 2 group respectively; the nutrition food for protecting the heart and promoting the liver health has a synergistic effect on reducing the liver index of rats.
Experimental example 2 trial eating experiment of population
The nutritional food for protecting the heart and promoting the liver health prepared in example 6 was used as an experimental sample to perform a human feeding trial experiment.
The traditional Chinese medicine diagnosis of the discomfort of the cardiac region is taken as a subject inclusion standard: weakness of limbs, chest distress, chest pain, palpitation, tachycardia, and heart rate greater than 90 times/min. Subject 30, 17 men and 13 women, none of which had other serious diseases. The subjects were between 46-75 years of age, with an average age of 62.1 years.
The curative effect judgment shows the effect: the fatigue disappears and the body is forceful; chest distress and chest pain are obviously relieved; palpitation, tachycardia is obviously relieved, and the heart rate is less than 90 times/minute; the method has the following advantages: the limbs are soft and weak, palpitation and palpitation are relieved; and (4) invalidation: no change in symptoms.
The experimental method comprises the following steps: the subject takes the above experimental samples 1 time a day, 15 g each time, and takes with warm boiled water. The observation period is 3 months. In the trial experiment, other medicines and nutritional health products are stopped taking, and the diet is normal.
The experimental results are as follows: of 30 subjects, 16 subjects showed efficacy, 11 subjects showed efficacy, and 3 subjects did not show efficacy, with a total effective rate of 90%. Wherein the symptoms of the effective subjects are relieved after taking the composition for 1 month, and the symptoms are obviously improved after taking the composition for 3 months. All subjects showed no symptoms of discomfort during the feeding trial.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (8)
1. A nutritional food for protecting heart and promoting liver health is characterized by being prepared from the following raw materials in parts by weight: 10 parts of cordyceps militaris, 8 parts of agaricus blazei, 8 parts of birch mushroom, 2 parts of grifola frondosa, 5 parts of poria cocos, 5 parts of radix puerariae, 2 parts of dry saussurea involucrate culture, 2 parts of emblic leafflower fruit, 3 parts of earthworm protein, 2 parts of corn oligopeptide powder, 3 parts of chia seed and 2 parts of linseed;
the preparation method of the nutritional food for protecting heart and promoting liver health comprises the following steps:
1) weighing the required raw materials according to the proportion; mixing Cordyceps militaris, Agaricus blazei, birch mushroom, maitake mushroom, Poria, radix Puerariae, dry product herba Saussureae Involueratae culture, and fructus Phyllanthi, reflux-extracting with 70% ethanol for 2 times, extracting with 8 times of ethanol for 3 hr for the 1 st time, extracting with 6 times of ethanol for 1 hr for the 2 nd time, filtering, and collecting residue; mixing filtrates, and concentrating the filtrate to obtain extract I with relative density of 1.10 at 30 deg.C;
2) decocting the filter residue obtained from the filter residue obtained in the step 1) with water for 2 times, adding 10 times of weight of water for decocting for 2 hours in the 1 st time, adding 8 times of weight of water for extracting for 1 hour in the 2 nd time, mixing decoctions, filtering, and concentrating the filtrate to obtain extract II with relative density of 1.10 and 30 deg.C;
3) mixing the obtained extract I and extract II, drying, and pulverizing; adding Lumbricus protein, semen Maydis oligopeptide powder, chia seed powder and semen Lini powder, mixing, and pulverizing to 100 mesh powder of 150 mesh.
2. The heart-protecting and liver-health promoting nutritional food as claimed in claim 1, wherein the earthworm protein has a protein content of 65% or more; and/or the presence of a gas in the gas,
the protein content of the corn oligopeptide powder is more than or equal to 80 percent, and the peptide content is more than or equal to 75 percent; and/or the presence of a gas in the gas,
the particle size of the nutritional food for protecting the heart and promoting the liver health is 100-150 meshes.
3. The heart-protecting and liver-health promoting nutritional food as claimed in claim 1, wherein the chia seed powder and flaxseed powder are prepared by pulverizing chia seed and flaxseed respectively, and sieving with 100-150 mesh sieve.
4. The method of preparing a nutraceutical for protecting the heart and promoting liver health of claim 1, comprising the steps of:
1) weighing the required raw materials according to the proportion; mixing Cordyceps militaris, Agaricus blazei, birch mushroom, maitake mushroom, Poria, radix Puerariae, dry product herba Saussureae Involueratae culture, and fructus Phyllanthi, reflux-extracting with 70% ethanol for 2 times, extracting with 8 times of ethanol for 3 hr for the 1 st time, extracting with 6 times of ethanol for 1 hr for the 2 nd time, filtering, and collecting residue; mixing filtrates, and concentrating the filtrate to obtain extract I with relative density of 1.10 at 30 deg.C;
2) decocting the filter residue obtained from the filter residue obtained in the step 1) with water for 2 times, adding 10 times of weight of water for decocting for 2 hours in the 1 st time, adding 8 times of weight of water for extracting for 1 hour in the 2 nd time, mixing decoctions, filtering, and concentrating the filtrate to obtain extract II with relative density of 1.10 and 30 deg.C;
3) mixing the obtained extract I and extract II, drying, and pulverizing; adding Lumbricus protein, semen Maydis oligopeptide powder, chia seed powder and semen Lini powder, mixing, and pulverizing to 100 mesh powder of 150 mesh.
5. A preparation comprising the heart-protecting and liver-health promoting nutritional food according to any one of claims 1 to 3.
6. The preparation according to claim 5, wherein the preparation further comprises adjuvants and/or additives used in the food field; alternatively, the formulation further comprises a pharmaceutically acceptable carrier.
7. The formulation of claim 5, wherein the formulation is a tablet, capsule, granule, tabletted candy, powder.
8. Use of the heart-protecting and liver-health promoting nutritional food or its preparation according to any one of claims 1 to 3 for the preparation of a food or a pharmaceutical product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102462740A (en) * | 2010-11-18 | 2012-05-23 | 四川科伦药物研究有限公司 | Pharmaceutical composition for relieving alcoholism and protecting liver and preparation method thereof |
| CN106975069A (en) * | 2017-05-02 | 2017-07-25 | 青岛康迈臣生物科技有限责任公司 | A kind of liver protecting composition and preparation method thereof |
| CN107412284A (en) * | 2017-08-21 | 2017-12-01 | 侯倩女 | Treat food drug composition, the preparation method and applications of diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102462740A (en) * | 2010-11-18 | 2012-05-23 | 四川科伦药物研究有限公司 | Pharmaceutical composition for relieving alcoholism and protecting liver and preparation method thereof |
| CN106975069A (en) * | 2017-05-02 | 2017-07-25 | 青岛康迈臣生物科技有限责任公司 | A kind of liver protecting composition and preparation method thereof |
| CN107412284A (en) * | 2017-08-21 | 2017-12-01 | 侯倩女 | Treat food drug composition, the preparation method and applications of diabetes |
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