CN101450129A - Traditional Chinese medicine composition with blood-pressure reduction and blood-fat reduction function - Google Patents
Traditional Chinese medicine composition with blood-pressure reduction and blood-fat reduction function Download PDFInfo
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- CN101450129A CN101450129A CNA2007101785095A CN200710178509A CN101450129A CN 101450129 A CN101450129 A CN 101450129A CN A2007101785095 A CNA2007101785095 A CN A2007101785095A CN 200710178509 A CN200710178509 A CN 200710178509A CN 101450129 A CN101450129 A CN 101450129A
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- chinese medicine
- blood
- medicine composition
- fructus crataegi
- folium nelumbinis
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Abstract
The invention discloses a traditional Chinese medicine composition with blood pressure and blood fat reducing function and preparation method thereof. The traditional Chinese medicine is made from haw, cassia seed and lotus leaf according to a certain weight proportion; and it can be made into any common oral taken preparation form. The Chinese traditional medicine composition in the invention achieves blood pressure and blood fat reducing function, and can be used to treat hypertension and hyperlipidemia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, belong to Chinese medicine and field of health care food with blood pressure lowering, hypolipemic function.
Background technology
The prevalence of hypertension, hyperlipemia had the trend of remarkable rising in recent years in the population of China.Along with the raising of living standards of the people, some undesired life style as high sugar, high Animal fat meals, few motion, smoking, heavy drinking, weight increase etc., are the major reasons that causes hypertension, hyperlipemia, also are the risk factors that causes coronary heart disease.At present, the medicine of treatment hypertension, hyperlipemia is a lot, but Western medicine reducing blood pressure and blood fat medicine all exists in various degree side effect such as gastrointestinal side effect, and is difficult to radical cure.
Summary of the invention
The object of the invention just provides a kind of Chinese medicine composition with blood pressure lowering, hypolipemic function.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Fructus Crataegi 9-12 part, Semen Cassiae 9-15 part and Folium Nelumbinis 3-9 part
Be preferably:
6 parts on 10 parts of Fructus Crataegis, 12 parts of Semen Cassiaes and Folium Nelumbinis
The preparation method of Chinese medicine composition of the present invention is as follows:
Fructus Crataegi with described weight proportion, Semen Cassiae and Folium Nelumbinis add water or ethanol extracts, extracting solution is concentrated, dry, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
Fructus Crataegi with described weight proportion, Semen Cassiae and Folium Nelumbinis add 70% ethanol and carry out reflux, extract, 2 times, filter, merging filtrate, reclaim ethanol, concentrating under reduced pressure, drying under reduced pressure, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
Each drug mechanism is as follows among the present invention:
Fructus Crataegi: effect with promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.Clinical research confirmation, Fructus Crataegi can significantly reduce serum cholesterol and triglyceride, effectively prevents and treats atherosclerosis; Fructus Crataegi can also play heart tonifying and prevent anginal effect by strengthening myocardial contraction, increase cardiac output, coronary artery dilator blood vessel, coronary blood flow increasing, reduction myocardial oxygen consumption etc.In addition, the total flavones in the Fructus Crataegi has the effect of blood vessel dilating and lasting blood pressure lowering.
Semen Cassiae: have the effect of clearing away heat to improve acuity of vision, loosening bowel to relieve constipation, reduction serum cholesterol, blood pressure lowering, be used for the treatment of the puckery pain of conjunctival congestion, dizzy, the poor vision of headache, hypertension, sclerosis of blood vessels.
Folium Nelumbinis: have the effect of clearing away summer-heat, suppressing the hyperactive liver blood fat reducing, be used for the treatment of that summer-heat excessive thirst, xerostomia taking fluids profusely, oliguria with yellow urine, the vertigo, red complexion are red, hypertension, hyperlipidemia.
In the present composition, Fructus Crataegi circulation of qi promoting dissipating blood stasis, Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation, the Folium Nelumbinis clearing away summer-heat, three flavor medicines all are the Chinese medicine that is fit to very much the integration of edible and medicinal herbs that the hypertension, hyperlipemia patient takes, promptly solved the hypertension, hyperlipemia patient common have a dizzy spell, the symptom of irritated, constipation, fundamentally blood pressure lowering, blood fat reducing, vessel softening again reach the effect for the treatment of both the principal and secondary aspects of a disease.
In sum, the present composition has the effect of blood fat reducing, blood pressure lowering.Can be used for preparation treatment hyperlipidemia, hypertensive medicine and health product.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment:
The experiment of product blood lipid regulation function of the present invention:
Animal: secondary Wistar male rat; High lipid food: 79% normal feedstuff, 1% cholesterol, 10% yolk powder, 10% Adeps Sus domestica.
The Wistar male rat of buying is after Animal House adapts to a week, and fasting 12 hours is weighed, and gets tail hematometry serum total cholesterol (TC) level; Body weight and serum TC level according to rat are divided into four groups, and 10 every group is respectively matched group (NC), low dose group (LD), middle dosage group (MD), high dose group (HD).There was no significant difference between initial body weight of four group rats and the serum TC level.
Three experimental grouies are except that the high lipid food of feeding, and irritate stomach with high, medium and low dosage group and give animal subject every day.Experiment periods 28 days was weighed in the time of the 14th, 28 day respectively, got tail hematometry blood lipids index.Comprise serum total cholesterol (TC), triglyceride (TG), HDL-C (HDL-C).
This experimental result shows, compares with the control rats of the high lipid food of feeding, and the product of the present invention that gives high dose group can make that serum TC concentration significantly descends, HDL-C/TC ratio significantly raises, and the significant difference (P＜0.05) on the statistics is all arranged.Product of the present invention has the effect of blood fat reducing.
The experiment of product blood pressure regulation function of the present invention:
Laboratory animal: spontaneous hypertensive rat (SHR); Apoplectic type spontaneous hypertensive rat (SHRsp); The Wister rat; Domesticated dog; Kunming mouse.
Pharmaceutical composition of the present invention is irritated stomach with high, medium and low dosage respectively gives rat, mice, dog, prove that by experiment pharmaceutical composition of the present invention has following pharmacological action:
Influence to SHR and SHRsp rat blood pressure: three dosage groups all can obviously stop SHR rat model increased blood pressure, there were significant differences with model control group (P＜0.01) from administration the 2nd week beginning, and drug withdrawal relatively still has significance difference (P＜0.01) with model control group after 4 weeks.Dosed administration group big or middle has obvious hypotensive effect to the SHRsp rat model, blood pressure is from begin promptly with model control group significant difference (P＜0.01) is arranged relatively in the 1st week of administration, and the heavy dose of group in 4 week of drug withdrawal back relatively still has significance difference (P＜0.01) with model control group.
Influence to the renal artery stenosis rat blood pressure: three dosed administration groups can obviously stop renal artery stenosis model hypertensive rat blood pressure to rise, and there were significant differences (P＜0.01) from beginning blood pressure and model control group in the 1st week of administration.
To the hemodynamic influence of normal dogs: big or middle dosage group after administration 1-2.5 hour, dog shrinks to be pressed with in various degree and reduces, and its reduction amplitude and matched group relatively have significant difference (P＜0.05P＜0.01); 1-2.5 hour total peripheral vascular resistance obviously reduces after the administration of heavy dose of group, 1.5 hours diastolic pressures obviously reduce after the administration, and its reduction amplitude and matched group relatively have significant difference (P＜0.05).Three dosage of administration group all do not have obvious influence to dog left indoor pressure, left ventricular end diastolic presssure and mean arterial pressure, heart rate and cardiac output.
Microcirculation of mouse auricle is influenced: the big or middle dosage of administration group has the arteriolar effect of obvious expansion Mice Auricle, and the changing value and the matched group of tremulous pulse bore relatively have significance difference (P＜0.05P＜0.01) before and after its administration; Administration group heavy dose can reduce erythrocytic aggregation in Mice Auricle small artery and the blood capillary, and significance difference (P＜0.01) is arranged relatively before the administration; Venule bore and blood flow rate there is not obvious influence.
Influence to renal artery stenosis Hypertensive Rats blood plasma medium vessels active substance, three dosage of administration group have in various degree reduction effect to the nervous plain II of renal artery stenosis Hypertensive Rats blood plasma medium vessels, aldosterone and content of ET, with model control group significance difference (P＜0.05P＜0.01) are arranged relatively; To atrial natriuretic peptide, fall calcio and do not have obvious influence because of related peptides.
Influence to renal hypertensive rat serum intermediate ion: three dosage of administration group have tangible reduction effect to sodium ion in the renal artery stenosis Hypertensive Rats serum, with model control group significance difference (P＜0.05P＜0.01) are arranged relatively; K+, Ca++ there is not obvious influence.
Pharmacodynamic study is the result confirmed, drug combination preparation of the present invention has stronger treatment hypertension effect.
The specific embodiment
Embodiment 1:
The preparation of the capsule of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi 10kg, Semen Cassiae 12kg, Folium Nelumbinis 6kg, standby through screening, clean, dry, pulverizing;
B) with Fructus Crataegi, Semen Cassiae, the Folium Nelumbinis ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi 9kg, Semen Cassiae 9kg, Folium Nelumbinis 3kg, standby through screening, clean, dry, pulverizing;
B) with green tea, Folium Ginkgo, Fructus Crataegi, Flos Chrysanthemi and the Fructus Lycii ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi 12kg, Semen Cassiae 15kg, Folium Nelumbinis 9kg, standby through screening, clean, dry, pulverizing;
B) green tea, Folium Ginkgo, Fructus Crataegi, Flos Chrysanthemi and Fructus Lycii are extracted twice with 10 times of amounts and 8 times of water gagings, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 4:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi 11kg, Semen Cassiae 12kg, Folium Nelumbinis 9kg, standby through screening, clean, dry, pulverizing;
B) with green tea, Folium Ginkgo, Fructus Crataegi, Flos Chrysanthemi and the Fructus Lycii ethanol extraction twice with 10 times of amounts and 8 times of amounts 80%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 5:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi 12kg, Semen Cassiae 12kg, Folium Nelumbinis 6kg, standby through screening, clean, dry, pulverizing;
B) with green tea, Folium Ginkgo, Fructus Crataegi, Flos Chrysanthemi and the Fructus Lycii ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 6:
The preparation of the effervescent tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi 11kg, Semen Cassiae 9kg, Folium Nelumbinis 3kg, standby through screening, clean, dry, pulverizing;
B) with green tea, Folium Ginkgo, Fructus Crataegi, Flos Chrysanthemi and the Fructus Lycii ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Embodiment 7:
The preparation of the dispersible tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi 10kg, Semen Cassiae 9kg, Folium Nelumbinis 9kg, standby through screening, clean, dry, pulverizing;
B) with green tea, Folium Ginkgo, Fructus Crataegi, Flos Chrysanthemi and the Fructus Lycii ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added disintegrating agent, filler or diluent, mix homogeneously adds binding agent and makes soft material, the system granule, and drying adds part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of Chinese medicine composition with blood pressure lowering, effect for reducing blood fat is characterized in that, it is to be made by following bulk drugs: Fructus Crataegi 9-12 part, Semen Cassiae 9-15 part and Folium Nelumbinis 3-9 part.
According to the Chinese medicine composition of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: 6 parts on 10 parts of Fructus Crataegis, 12 parts of Semen Cassiaes and Folium Nelumbinis.
3, the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that, this method is:
Fructus Crataegi, Semen Cassiae and the Folium Nelumbinis of described weight proportion added water or ethanol extracts, extracting solution is concentrated, drying makes dry extract, is ground into powder, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:
Fructus Crataegi, Semen Cassiae and the Folium Nelumbinis of described weight proportion added the ethanol extraction twice of 10 times of amounts and 8 times of amounts 70%, and merge extractive liquid, filters, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30, drying under reduced pressure down for 60 ℃, make dry extract, be ground into powder, be prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described Chinese medicine compositions are used to prepare prevention and treatment hypertension, the medicine of hyperlipidaemic conditions or the application of health food.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785095A CN101450129A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood-pressure reduction and blood-fat reduction function |
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| CNA2007101785095A CN101450129A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood-pressure reduction and blood-fat reduction function |
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| CN101450129A true CN101450129A (en) | 2009-06-10 |
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Cited By (16)
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| CN102423352A (en) * | 2011-12-13 | 2012-04-25 | 广东众生药业股份有限公司 | Chinese medicinal granules for treating cardio-cerebrovascular diseases |
| CN103393101A (en) * | 2013-06-29 | 2013-11-20 | 安徽皖山食品有限公司 | Lotus leaf lipid-lowering cream and preparation method thereof |
| CN103494277A (en) * | 2011-07-19 | 2014-01-08 | 江西江中制药(集团)有限责任公司 | Lipid-lowering weight-losing lotus leaf beverage and preparation method thereof |
| CN103876142A (en) * | 2014-03-25 | 2014-06-25 | 山东农业工程学院 | Superfine powder chewable tablets with functions of beautifying and slimming, and preparation method thereof |
| CN104257811A (en) * | 2014-09-16 | 2015-01-07 | 四川众鼎中药发展有限公司 | Food, health product or pharmaceutical composition with effect of protecting liver |
| CN104645093A (en) * | 2013-11-26 | 2015-05-27 | 赵凯 | Traditional Chinese medicine composition for treating hypertension |
| CN105267431A (en) * | 2015-09-30 | 2016-01-27 | 李文 | Ready-to-drink traditional Chinese medicinal health product composition with blood fat lowering effect |
| CN105343471A (en) * | 2015-11-26 | 2016-02-24 | 重庆壹心堂贸易有限公司 | Preparation method of traditional Chinese medicine with hypolipidemic effect |
| CN106176907A (en) * | 2016-08-31 | 2016-12-07 | 哈尔滨医科大学 | Raise for reducing the blood fat caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof |
| CN107007695A (en) * | 2017-04-20 | 2017-08-04 | 严跃华 | A kind of toxin expelling of invigorating blood circulation purifies the blood the Chinese prescription and its preparation of fat |
| CN107029127A (en) * | 2017-03-14 | 2017-08-11 | 广东轻工职业技术学院 | A kind of Chinese medicine preparation with regulating blood lipid action and preparation method thereof |
| CN107213391A (en) * | 2017-07-21 | 2017-09-29 | 成都柏图生物科技有限公司 | One kind has strengthening spleen and nourishing stomach, and help digestion pharmaceutical composition of tune fat and preparation method thereof |
| CN107334870A (en) * | 2017-06-23 | 2017-11-10 | 防城港康众生物保健有限公司 | A kind of composition of hypotensive and preparation method thereof |
| CN109568408A (en) * | 2019-01-22 | 2019-04-05 | 张淑敏 | A kind of health-caring capsule with treatment acute chemical liver injury function |
| CN111153942A (en) * | 2019-07-09 | 2020-05-15 | 山东省科学院生物研究所 | Preparation method of ACE (angiotensin converting enzyme) inhibitory active compound from hawthorn flower |
| CN114010703A (en) * | 2021-11-22 | 2022-02-08 | 长沙医学院 | Chinese herbal medicine composition and preparation and application thereof |
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2007
- 2007-11-30 CN CNA2007101785095A patent/CN101450129A/en active Pending
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| CN103494277A (en) * | 2011-07-19 | 2014-01-08 | 江西江中制药(集团)有限责任公司 | Lipid-lowering weight-losing lotus leaf beverage and preparation method thereof |
| CN102423352A (en) * | 2011-12-13 | 2012-04-25 | 广东众生药业股份有限公司 | Chinese medicinal granules for treating cardio-cerebrovascular diseases |
| CN103393101A (en) * | 2013-06-29 | 2013-11-20 | 安徽皖山食品有限公司 | Lotus leaf lipid-lowering cream and preparation method thereof |
| CN104645093A (en) * | 2013-11-26 | 2015-05-27 | 赵凯 | Traditional Chinese medicine composition for treating hypertension |
| CN103876142B (en) * | 2014-03-25 | 2016-04-13 | 山东农业工程学院 | A kind of Ultramicro-powder chewable tablets with beauty treatment weight reducing effect and preparation method thereof |
| CN103876142A (en) * | 2014-03-25 | 2014-06-25 | 山东农业工程学院 | Superfine powder chewable tablets with functions of beautifying and slimming, and preparation method thereof |
| CN104257811A (en) * | 2014-09-16 | 2015-01-07 | 四川众鼎中药发展有限公司 | Food, health product or pharmaceutical composition with effect of protecting liver |
| CN105267431A (en) * | 2015-09-30 | 2016-01-27 | 李文 | Ready-to-drink traditional Chinese medicinal health product composition with blood fat lowering effect |
| CN105343471A (en) * | 2015-11-26 | 2016-02-24 | 重庆壹心堂贸易有限公司 | Preparation method of traditional Chinese medicine with hypolipidemic effect |
| CN106176907A (en) * | 2016-08-31 | 2016-12-07 | 哈尔滨医科大学 | Raise for reducing the blood fat caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof |
| CN107029127A (en) * | 2017-03-14 | 2017-08-11 | 广东轻工职业技术学院 | A kind of Chinese medicine preparation with regulating blood lipid action and preparation method thereof |
| CN107007695A (en) * | 2017-04-20 | 2017-08-04 | 严跃华 | A kind of toxin expelling of invigorating blood circulation purifies the blood the Chinese prescription and its preparation of fat |
| CN107334870A (en) * | 2017-06-23 | 2017-11-10 | 防城港康众生物保健有限公司 | A kind of composition of hypotensive and preparation method thereof |
| CN107213391A (en) * | 2017-07-21 | 2017-09-29 | 成都柏图生物科技有限公司 | One kind has strengthening spleen and nourishing stomach, and help digestion pharmaceutical composition of tune fat and preparation method thereof |
| CN109568408A (en) * | 2019-01-22 | 2019-04-05 | 张淑敏 | A kind of health-caring capsule with treatment acute chemical liver injury function |
| CN111153942A (en) * | 2019-07-09 | 2020-05-15 | 山东省科学院生物研究所 | Preparation method of ACE (angiotensin converting enzyme) inhibitory active compound from hawthorn flower |
| CN111153942B (en) * | 2019-07-09 | 2021-07-13 | 山东省科学院生物研究所 | Preparation method of ACE (angiotensin converting enzyme) inhibitory active compound from hawthorn flower |
| CN114010703A (en) * | 2021-11-22 | 2022-02-08 | 长沙医学院 | Chinese herbal medicine composition and preparation and application thereof |
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Open date: 20090610 |