CN116098224A - Pressed candy for regulating uric acid and preparation method thereof - Google Patents
Pressed candy for regulating uric acid and preparation method thereof Download PDFInfo
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- CN116098224A CN116098224A CN202111329225.8A CN202111329225A CN116098224A CN 116098224 A CN116098224 A CN 116098224A CN 202111329225 A CN202111329225 A CN 202111329225A CN 116098224 A CN116098224 A CN 116098224A
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 title claims abstract description 45
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 229940116269 uric acid Drugs 0.000 title claims abstract description 45
- 235000009508 confectionery Nutrition 0.000 title claims abstract description 34
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 13
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 13
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 13
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 13
- 229940107187 fructooligosaccharide Drugs 0.000 claims abstract description 13
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 13
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 13
- 210000000582 semen Anatomy 0.000 claims abstract description 13
- 239000000811 xylitol Substances 0.000 claims abstract description 13
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 13
- 229960002675 xylitol Drugs 0.000 claims abstract description 13
- 235000010447 xylitol Nutrition 0.000 claims abstract description 13
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 10
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 10
- 244000197580 Poria cocos Species 0.000 claims abstract description 10
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 10
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims abstract description 10
- 244000223014 Syzygium aromaticum Species 0.000 claims abstract description 10
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 10
- 235000011477 liquorice Nutrition 0.000 claims abstract description 10
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims abstract description 8
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 8
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 8
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 8
- 244000234609 Portulaca oleracea Species 0.000 claims abstract description 8
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 8
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 6
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 5
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 5
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 5
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 5
- 240000000950 Hippophae rhamnoides Species 0.000 claims abstract 3
- 238000002156 mixing Methods 0.000 claims description 15
- 241000218236 Cannabis Species 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 241000229143 Hippophae Species 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 5
- 235000003935 Hippophae Nutrition 0.000 claims description 5
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- 235000004879 dioscorea Nutrition 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 9
- 229940126673 western medicines Drugs 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 240000004308 marijuana Species 0.000 abstract 1
- 201000001431 Hyperuricemia Diseases 0.000 description 6
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 4
- 229960003459 allopurinol Drugs 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 3
- 230000003355 alkalizing urine Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229940126532 prescription medicine Drugs 0.000 description 2
- 241001260012 Bursa Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- 208000019025 Hypokalemia Diseases 0.000 description 1
- 206010021036 Hyponatraemia Diseases 0.000 description 1
- 229940087098 Oxidase inhibitor Drugs 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002529 benzbromarone Drugs 0.000 description 1
- WHQCHUCQKNIQEC-UHFFFAOYSA-N benzbromarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(Br)=C(O)C(Br)=C1 WHQCHUCQKNIQEC-UHFFFAOYSA-N 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 208000024896 potassium deficiency disease Diseases 0.000 description 1
- 229960003081 probenecid Drugs 0.000 description 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a pressed candy for regulating uric acid and a preparation method thereof. The uric acid regulating tablet candy is prepared from the following raw materials in parts by weight: 35-40 parts of clove, 10-20 parts of liquorice, 6-12 parts of Chinese yam, 8-10 parts of poria cocos, 10-15 parts of medlar, 5-10 parts of fructus cannabis, 3-7 parts of purslane, 7-10 parts of sea buckthorn, 4-10 parts of semen cassiae, 1-3 parts of fructo-oligosaccharide, 1-5 parts of xylitol and 1-5 parts of maltodextrin. The pressed candy is prepared from a plurality of traditional Chinese medicine raw materials such as clove, liquorice, chinese yam, poria cocos and the like through the procedures of decoction, concentration, crushing, drying, tabletting and the like, and has the advantages of simple preparation process, definite curative effect, safety and no toxic or side effect. In addition, compared with the existing uric acid regulating medicines, the traditional Chinese medicine can effectively regulate uric acid in human body, reduce uric acid content in human body and enable uric acid content to be recovered to normal level, and can replace the existing clinical western medicines to treat patients with high uric acid, so that side effects of western medicines on human body are avoided.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a pressed candy for regulating uric acid and a preparation method thereof.
Background
Hyperuricemia is a metabolic disease caused by the increase of uric acid in blood due to the disturbance of metabolism of purine substances in human body. Clinically, the normal value of uric acid in men is 149-416umol/L, and the normal value of uric acid in women is 89-359umol/L. For healthy humans, the daily uric acid production and excretion are about equal, which leads to elevated uric acid when problems occur in uric acid excretion. Hyperuricemia is prone to uric acid crystallization, which deposits in joint synovium, bursa, cartilage and other tissues causing recurrent disease of ventilation.
Clinically, the medicines for treating the hyperuricemia comprise a prescription medicine for uric acid, a medicine for inhibiting uric acid generation and a medicine for alkalizing urine, wherein the prescription medicine for uric acid mainly comprises probenecid, benzbromarone and the like, and the medicines can prevent the reabsorption of renal tubules on uric acid and increase the discharge of uric acid, but can generate side effects of hyponatremia, hypokalemia and hypocalcemia of human bodies and have side effects on livers and kidneys. The drug for inhibiting uric acid production is a purine oxidase inhibitor which is commonly used in clinic and can effectively reduce uric acid production, but has side effects on liver and kidney functions of human body. The alkalizing urine medicine has no effect of reducing uric acid, but can alkalize urine, increase the solution degree of urine in blood, avoid the accumulation of uric acid in urine to form crystallization, but has limited curative effect on treating hyperuricemia, and can cause other organ diseases of human body after long-term administration.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
Disclosure of Invention
In order to solve the existing problems, the invention provides a pressed candy for regulating uric acid and a preparation method thereof.
The technical scheme of the invention is as follows:
the uric acid regulating tablet candy is prepared from the following raw materials in parts by weight: 35-40 parts of clove, 10-20 parts of liquorice, 6-12 parts of Chinese yam, 8-10 parts of poria cocos, 10-15 parts of medlar, 5-10 parts of fructus cannabis, 3-7 parts of purslane, 7-10 parts of sea buckthorn, 4-10 parts of semen cassiae, 1-3 parts of fructo-oligosaccharide, 1-5 parts of xylitol and 1-5 parts of maltodextrin.
Preferably, the material is prepared from the following raw materials in parts by weight: 38 parts of clove, 15 parts of liquorice, 9 parts of yam, 9 parts of poria cocos, 12 parts of medlar, 7 parts of fructus cannabis, 5 parts of purslane, 8 parts of sea buckthorn, 7 parts of semen cassiae, 2 parts of fructo-oligosaccharide, 3 parts of xylitol and 3 parts of maltodextrin.
The second object of the present invention is to provide a method for preparing the above-mentioned tabletted candy, comprising the steps of:
(1) Weighing the raw materials according to the weight portion, cleaning and airing;
(2) Mixing flos Caryophylli, glycyrrhrizae radix, rhizoma Dioscoreae, poria, fructus Lycii, fructus Cannabis, herba Portulacae, fructus Hippophae and semen Cassiae, pulverizing, sieving with 60-80 mesh sieve, decocting with 10-12 times of water for 2 times, the first time for 2 hr and the second time for 1.5 hr, mixing decoctions, filtering, collecting filtrate, and concentrating to obtain extract;
(3) And (3) drying the extract obtained in the step (2) by hot air, crushing, adding fructo-oligosaccharide, xylitol and maltodextrin, mixing, transferring to a tablet press for tabletting, and packaging.
Preferably, the extract has a relative density of 1.25-1.33 at 60 ℃.
Preferably, the water content of each tablet of the pressed candy is 0.75-0.85g, and is lower than 3%.
Compared with the prior art, the invention has the following beneficial effects:
(1) The pressed candy is prepared from a plurality of traditional Chinese medicine raw materials such as clove, liquorice, chinese yam, poria cocos and the like through the procedures of decoction, concentration, crushing, drying, tabletting and the like, and has the advantages of simple preparation process, definite curative effect, safety and no toxic or side effect.
(2) Compared with the existing uric acid regulating drugs, the tablet candy disclosed by the invention can effectively regulate uric acid in human body, reduce uric acid content in human body and enable uric acid content to be recovered to normal level, and can replace the existing clinical western medicines to treat patients with hyperuricemia, so that side effects of western medicines on human body are avoided.
Detailed Description
The following detailed description of specific embodiments of the invention is, but it should be understood that the invention is not limited to specific embodiments.
Example 1
The uric acid regulating tablet candy is prepared from the following raw materials in parts by weight: 35g of clove, 10g of liquorice, 6g of yam, 8g of poria cocos, 10g of medlar, 5g of fructus cannabis, 3g of purslane, 7g of sea buckthorn, 4g of semen cassiae, 1g of fructo-oligosaccharide, 1g of xylitol and 1g of maltodextrin.
The preparation method of the pressed candy comprises the following steps:
(1) Weighing the raw materials according to the weight, cleaning and airing;
(2) Mixing flos Caryophylli, glycyrrhrizae radix, rhizoma Dioscoreae, poria, fructus Lycii, fructus Cannabis, herba Portulacae, fructus Hippophae and semen Cassiae, pulverizing, sieving with 60 mesh sieve, decocting with 10 times of water for 2 times, the first time for 2h, the second time for 1.5h, mixing decoctions, filtering, collecting filtrate, concentrating to obtain extract with relative density of 1.25 at 60deg.C;
(3) Drying the extract obtained in the step (2) by hot air, crushing, adding fructo-oligosaccharide, xylitol and maltodextrin, mixing, transferring to a tablet press for tabletting, and packaging;
wherein, in the step (3), each tablet of the pressed candy contains 0.75g and 2% of water.
Example 2
The uric acid regulating tablet candy is prepared from the following raw materials in parts by weight: 38g of clove, 15g of liquorice, 9g of yam, 9g of poria cocos, 12g of medlar, 7g of fructus cannabis, 5g of purslane, 8g of sea buckthorn, 7g of semen cassiae, 2g of fructo-oligosaccharide, 3g of xylitol and 3g of maltodextrin;
the preparation method of the pressed candy comprises the following steps:
(1) Weighing the raw materials according to the weight, cleaning and airing;
(2) Mixing flos Caryophylli, glycyrrhrizae radix, rhizoma Dioscoreae, poria, fructus Lycii, fructus Cannabis, herba Portulacae, fructus Hippophae and semen Cassiae, pulverizing, sieving with 70 mesh sieve, decocting with 12 times of water for 2 times, the first time for 2h, the second time for 1.5h, mixing decoctions, filtering, collecting filtrate, concentrating to obtain extract with relative density of 1.29 at 60deg.C;
(3) Drying the extract obtained in the step (2) by hot air, crushing, adding fructo-oligosaccharide, xylitol and maltodextrin, mixing, transferring to a tablet press for tabletting, and packaging;
wherein, in the step (3), each tablet of the pressed candy contains 0.8g and the water content is lower than 2.3 percent.
Example 3
The uric acid regulating tablet candy is prepared from the following raw materials in parts by weight: 40g of clove, 20g of liquorice, 12g of yam, 10g of poria cocos, 15g of medlar, 10g of fructus cannabis, 7g of purslane, 10g of sea buckthorn, 10g of semen cassiae, 3g of fructo-oligosaccharide, 5g of xylitol and 5g of maltodextrin;
the preparation method of the pressed candy comprises the following steps:
(1) Weighing the raw materials according to the weight, cleaning and airing;
(2) Mixing flos Caryophylli, glycyrrhrizae radix, rhizoma Dioscoreae, poria, fructus Lycii, fructus Cannabis, herba Portulacae, fructus Hippophae and semen Cassiae, pulverizing, sieving with 80 mesh sieve, decocting with 12 times of water for 2 times, the first time for 2h, the second time for 1.5h, mixing decoctions, filtering, collecting filtrate, concentrating to obtain extract with relative density of 1.33 at 60deg.C;
(3) Drying the extract obtained in the step (2) by hot air, crushing, adding fructo-oligosaccharide, xylitol and maltodextrin, mixing, transferring to a tablet press for tabletting, and packaging;
wherein, in the step (3), each tablet of the pressed candy contains 0.85g and 2.5% of water.
Clinical efficacy investigation
Mice model of hyperuricemia was established by intraperitoneal injection of a combination of oxygen-producing acid clock (dose 300mg/kg, 1 time daily for 6 consecutive weeks), and control group was intraperitoneally injected with physiological saline 1 time daily for 6 consecutive weeks.
Mice were randomly divided into 4 groups: control group, model group, drug group 1 and drug group 2, 30 mice per group, wherein the control group and model group were lavaged with 2mL of physiological saline; drug group 1, 15mL/10g of gastric-lavage allopurinol solution, 5g of allopurinol is dissolved in 100mL of distilled water; drug group 2 intragastric tabletted candy solution prepared in example 2 20mL/10g, tabletted candy solution was prepared by dissolving 0.8g tabletted candy in 100mL distilled water; each group above was gavaged 1 time per day for 3 consecutive weeks.
After 3 weeks, the mice 'eyeballs were removed, placed in centrifuge tubes, the mice' serum uric acid levels were measured, and the average value of each set of data was calculated, with the results shown in table 1 below.
TABLE 1 uric acid regulating effect of uric acid regulating tabletted candy of the present invention
| Group of | Serum uric acid content (mg/L) |
| Control group | 36.92 |
| Model group | 52.49 |
| Pharmaceutical group 1 | 43.23 |
| Pharmaceutical group 2 | 36.25 |
As can be seen from table 1, the tabletted candy of the present invention can effectively reduce serum uric acid content and restore to normal level; while allopurinol can reduce the uric acid content in serum, the effect of allopurinol is not as good as the tabletted candy of the invention.
In conclusion, the pressed candy disclosed by the invention can effectively regulate uric acid in a human body, reduce uric acid content in the human body and enable the uric acid content to be recovered to a normal level; various traditional Chinese medicine raw materials are selected for preparing the pressed candy, so that side effects on human bodies can be effectively avoided.
The foregoing descriptions of specific exemplary embodiments of the present invention are presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application to thereby enable one skilled in the art to make and utilize the invention in various exemplary embodiments and with various modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (5)
1. The uric acid regulating tabletting candy is characterized by being prepared from the following raw materials in parts by weight: 35-40 parts of clove, 10-20 parts of liquorice, 6-12 parts of Chinese yam, 8-10 parts of poria cocos, 10-15 parts of medlar, 5-10 parts of fructus cannabis, 3-7 parts of purslane, 7-10 parts of sea buckthorn, 4-10 parts of semen cassiae, 1-3 parts of fructo-oligosaccharide, 1-5 parts of xylitol and 1-5 parts of maltodextrin.
2. The tabletted candy according to claim 1, wherein the tabletted candy is prepared from the following raw materials in parts by weight: 38 parts of clove, 15 parts of liquorice, 9 parts of yam, 9 parts of poria cocos, 12 parts of medlar, 7 parts of fructus cannabis, 5 parts of purslane, 8 parts of sea buckthorn, 7 parts of semen cassiae, 2 parts of fructo-oligosaccharide, 3 parts of xylitol and 3 parts of maltodextrin.
3. A method of preparing a tabletted confection according to claim 1 or 2, comprising the steps of:
(1) Weighing the raw materials according to the weight portion, cleaning and airing;
(2) Mixing flos Caryophylli, glycyrrhrizae radix, rhizoma Dioscoreae, poria, fructus Lycii, fructus Cannabis, herba Portulacae, fructus Hippophae and semen Cassiae, pulverizing, sieving with 60-80 mesh sieve, decocting with 10-12 times of water for 2 times, the first time for 2 hr and the second time for 1.5 hr, mixing decoctions, filtering, collecting filtrate, and concentrating to obtain extract;
(3) And (3) drying the extract obtained in the step (2) by hot air, crushing, adding fructo-oligosaccharide, xylitol and maltodextrin, mixing, transferring to a tablet press for tabletting, and packaging.
4. The method according to claim 3, wherein the extract has a relative density of 1.25 to 1.33 at 60 ℃.
5. A method of manufacture according to claim 3 wherein the tabletted confection comprises from 0.75 to 0.85g per tablet with a moisture content of less than 3%.
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| CN117413882A (en) * | 2023-12-19 | 2024-01-19 | 中北大学德州产业技术研究院 | Preparation process of pressed candy containing sea buckthorn active ingredient |
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| CN117413882A (en) * | 2023-12-19 | 2024-01-19 | 中北大学德州产业技术研究院 | Preparation process of pressed candy containing sea buckthorn active ingredient |
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