CN1657085A - Oral Chinese medicinal composition for treating hypertension - Google Patents
Oral Chinese medicinal composition for treating hypertension Download PDFInfo
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- CN1657085A CN1657085A CN2004100356506A CN200410035650A CN1657085A CN 1657085 A CN1657085 A CN 1657085A CN 2004100356506 A CN2004100356506 A CN 2004100356506A CN 200410035650 A CN200410035650 A CN 200410035650A CN 1657085 A CN1657085 A CN 1657085A
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Abstract
An orally taken Chinese medicine for treating hypertension is prepared from prunella spike, uncaria stem with hooks, earthworm and cassia seed.
Description
Technical field
The invention belongs to the Chinese medicine technical field, specifically relate to the hypertensive oral Chinese medicine compositions of a kind of treatment.
Background technology
Hypertension be a kind of agnogenic serve as the systemic disease of main performance with the systemic arterial pressure rising, be again the human main diseases of suffering from coronary heart disease, cerebrovascular, heart failure, apoplexy because of.The western medical treatment medicine is various, but most contraindication of these medicines and side effect are more, and patient easily produces drug resistance to multiple medicine, often need drug combination at therapeutic process in addition, therefore, patient's dosage is many clinically, because hypertensive treatment need be taken medicine throughout one's life, make the medical expense costliness.
Modern Chinese medicine thinks that according to hypertensive clinical symptoms hypertension mainly belongs under the traditional Chinese medical science Liver Channel disease item, and is very close with relations such as dizzy, headache, liver-yang, liver-fire, liver-wind.Along with traditional Chinese medical science pharmacology, the research and development of pharmacodynamics confirms that multiple Chinese herbal medicine has certain hypotensive effect.In recent years, the medicine of Chinese traditional treatment hypertension obtains exploitation and development more, the big prescription of the many employings of these traditional Chinese medical science medicines, and flavour of a drug are many, and adopt some rare medicinal herbss; Yet these medicines have the few in number of significant curative effect, used herb resource shortage, and cost of drugs is higher, and along with the sharp increase of hypertension number of patients, can not satisfy the needs of patient far away.
Summary of the invention
Purpose of the present invention is exactly for fear of providing a kind of novel therapeutic hypertensive traditional Chinese medical science medicine with the shortcoming and defect that overcomes prior art, the inventor is at the shortcoming of existing treatment hypertension Chinese and western medicine medicine, big as toxic and side effects, easily produce drug resistance, curative effect is not remarkable, and cost is higher, can not satisfy patient's demand etc., carried out further investigation and inquired into, the medicine of the present invention that is proposed has the effect that liver heat removing is let out fire, suppressing the hyperactive liver to relieve the wind syndrome, brought high blood pressure down, and is applicable to essential hypertension.
The hypertensive Chinese medicine composition of a kind of treatment involved in the present invention mainly is to be made by following bulk drugs: Spica Prunellae, Ramulus Uncariae Cum Uncis, Pheretima, Semen Cassiae.The present invention selects the above-mentioned raw materials medicine to make up, and makes each efficacy of drugs produce synergism, thereby effectively treats hypertension.Spica Prunellae wherein, hot, bitter, tremble with fear, return liver, gallbladder meridian.Acrid in the mouth can loose, clearing up internal heat by using drugs of bitter in taste and cold in nature, and the kind stagnated fire of leading liver and gall off of merit, the operation of the mechanism of qi that passes unimpeded, " the southern regions of the Yunnan Province book on Chinese herbal medicine " calls it: " liver-wind of dispelling, the network of passing through.Control facial hemiparalysis.The row irritability is opened stagnation of liver-QI, ends bones and muscles pain, ophthal malgia ... ".So can let out diffusing liver-heat, liver-wind, with being monarch drug.Ramulus Uncariae Cum Uncis, sweet, cold.GUIXIN, Liver Channel can be let out liver-heat clearly, but endogenous wind stopping relieving convulsion again.The liver main air, pericardium master fire is for controlling the key medicine of fire and wind stirring up each other disease." Compendium of Materia Medica Ramulus Uncariae Cum Uncis " " the Ramulus Uncariae Cum Uncis brothers faint cloudy medicine also.The foot cloudy main air of fainting, the hands cloudy main fire of fainting, infantile convulsion is dizzy, liver-wind diseases of fire mutually all, the logical pericardium of Ramulus Uncariae Cum Uncis is in edema with the liver involved, the quiet fire breath of wind, then all diseases from except that ".Pheretima, salty, cold, return liver, spleen, urinary bladder channel.Salty-cold expelling the heat-evil, property is walked to scurry, and is good at heat clearing away, and endogenous wind stopping relieving convulsion again is so be used for disease due to the high fever.Semen Cassiae, sweet, hardship, salty, go into liver, kidney channel, there is suppressing the hyperactive liver to let out effect of fire.Normal and Ramulus Uncariae Cum Uncis, the same suppressing liver-YANG of using of Pheretima are with Spica Prunellae 5 usefulness mutually, Spica Prunellae nourishing the liver blood, Semen Cassiae kidney tonifying the moon.With treating hepatic and renal YIN deficiency, dizzy, headache that yin deficiency yang hyperactivity rose.This three medicine is ministerial drug altogether, principal drug assistance purging liver-heat, suppressing the hyperactive liver to relieve the wind syndrome.
For reaching better therapeutic, medicine of the present invention is also combined with Radix Scutellariae, Ramulus Et Folium Picrasmae, Plumula Nelumbinis, Radix Scutellariae, and bitter in the mouth is cold in nature, and clearing away heat-fire is used for dampness-heat in the liver and gallbladder, gastrointestinal excess-heat, the edema caused by disorder of QI excess-heat, high fever does not move back, few all cards of positive intenseness of heat.With Semen Cassiae 5 usefulness treating the liver fire persons, but with Ramulus Uncariae Cum Uncis 5 usefulness suppressing liver-YANGs, be used for the headache of excessive rising of liver-YANG, dizzy card.Plumula Nelumbinis, hardship is trembled with fear into the heart, and kidney channel is longer than clearing heart fire, kind hot worry god, heating coma or the vexed card of sleeping less controlled.The heat clearing away of Ramulus Et Folium Picrasmae tool, damp eliminating, detoxicating functions.Be used as adjuvant drug in this three prescription, principal drug assistance clearing heat, purging intense-heat, dampness detoxifcation.We's all bitter and cold medicines of collection and one are played liver heat removing altogether and are let out fire, the merit of suppressing the hyperactive liver to relieve the wind syndrome.
The consumption of its drug component of oral Chinese medicine compositions of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have better curative effect in the following weight parts scope:
Spica Prunellae 15-30 part, Ramulus Uncariae Cum Uncis 15-25 part, Pheretima 15-25 part, Semen Cassiae 15-25 part.
Preferred weight part scope is: Spica Prunellae 25-30 part, Ramulus Uncariae Cum Uncis 18-22 part, Pheretima 18-22 part, Semen Cassiae 18-22 part.
Ingredients weight parts of the present invention can also be Spica Prunellae 15-30 part, Ramulus Uncariae Cum Uncis 15-25 part, Pheretima 15-25 part, Semen Cassiae 15-25 part, Radix Scutellariae 8-15 part.
Be preferably Spica Prunellae 25-30 part, Ramulus Uncariae Cum Uncis 18-22 part, Pheretima 18-22 part, Semen Cassiae 18-22 part, Radix Scutellariae 10-12 part.
The medicine of the present invention further weight portion of each component is Spica Prunellae 15-30 part, Ramulus Uncariae Cum Uncis 15-25 part, Pheretima 15-25 part, Semen Cassiae 15-25 part, Radix Scutellariae 8-15 part, Ramulus Et Folium Picrasmae 7-15 part, Plumula Nelumbinis 8-15 part.
Be preferably: Spica Prunellae 25-30 part, Ramulus Uncariae Cum Uncis 18-22 part, Pheretima 18-22 part, Semen Cassiae 18-22 part, Radix Scutellariae 10-12 part, Ramulus Et Folium Picrasmae 9-12 part, Plumula Nelumbinis 10-12 part.
More preferred weight portion scope is: 27 parts of Spica Prunellaes, 20 parts of Ramulus Uncariae Cum Uncis, 20 parts of Pheretimas, 20 parts of Semen Cassiaes, 11 parts of Radix Scutellariaes, 10 parts of Ramulus Et Folium Picrasmaes, 12 parts of Plumula Nelumbiniss.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, capsule, oral liquid etc.
Medicine of the present invention can obviously reduce Canis familiaris L. systolic pressure, diastolic pressure and mean arterial pressure, reduce heart rate, cardiac output, cardiac index, prolongation left ventricular pressure, left chamber diastasis pressure, the maximum climbing speed of left indoor pressure, stroke work index, total oxygen consumption index and total peripheral resistance, left chamber and begin to be contracted to left indoor pressure climbing speed time to peak, increase stroke volume, SI, coronary flow, medicine of the present invention has remarkable coronary artery dilating blood flow, reduces the effect of myocardial oxygen consumption.
The specific embodiment
Further set forth the beneficial effect of medicine of the present invention by the following examples with experimental example.
Embodiment:
Prescription: Spica Prunellae 1350g, Ramulus Uncariae Cum Uncis 1000g, Pheretima 1000g, Semen Cassiae 1000g, Radix Scutellariae 550g, Ramulus Et Folium Picrasmae 500g, Plumula Nelumbinis 600g.
Method for making: Spica Prunellae respectively adds 6 times of alcohol with 95% alcohol reflux secondary, extracts 1.5 hours, merges alcohol extract, filters, and filtrate recycling ethanol, drying under reduced pressure gets Spica Prunellae extract; Ramulus Uncariae Cum Uncis, Ramulus Et Folium Picrasmae, Plumula Nelumbinis powder are broken into coarse powder, 80% alcohol heating reflux extracts secondary, respectively adds 7 times of alcohol, 2 hours for the first time, 1 hour for the second time, merge alcohol extract, filter, reclaim ethanol and be concentrated into relative density 1.15-1.25 (50 ℃), after cooling, regulate pH2-3 with dilute hydrochloric acid, leave standstill, filter, acid liquid is adjusted to neutrality with diluted sodium hydroxide solution, add ethanol and make and contain alcohol amount and reach 80%, leave standstill, filter, the alcoholic solution decompression recycling ethanol also is concentrated into relative density 1.30-1.35 (60 ℃), vacuum (70 ℃, 6.6KPa) drying gets extracts such as Ramulus Uncariae Cum Uncis; Radix Scutellariae decocts with water secondary, adds 10 times, 8 times water respectively, and each extracted 1 hour, filter, filtrate merges, and adds hydrochloric acid adjust pH 1.0-2.0, and 80 ℃ are incubated 30 minutes, the leaching precipitation, after adding a small amount of 50% washing with alcohol, 5 times of amounts of reuse washing with alcohol, (70 ℃ in vacuum, 6.6kg) drying, promptly get Radix Scutellariae extract; Pheretima, Semen Cassiae coarse grain, decocting boils secondary, adds 8 times in water at every turn, decocts 1.5 hours, collecting decoction filters, and filtrate is concentrated into relative density 1.10-1.15 (50 ℃), handle secondary with ethanol precipitation, make for the first time to contain the alcohol amount and reach 70%, cold preservation 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.10-1.15 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 80%, cold preservation 24 hours filters filtrate recycling ethanol, (70 ℃, 6.6KPa) drying gets Pheretima extract in decompression.Above-mentioned each extract is ground into coarse powder, adds 10% soluble starch, mixing, filled capsules is made 1000, promptly.
Usage and dosage: oral, one time 3,3 times on the one.
Specification: every dress 0.45g.
Preclinical pharmacology experiment: medicine of the present invention by duodenum give 2.6,5.2,10.4g crude drug/kg, the result shows that each dosage can obviously reduce Canis familiaris L. systolic pressure, diastolic pressure and mean arterial pressure, reduction heart rate, cardiac output, cardiac index, left ventricular pressure, left chamber diastasis pressure, the maximum climbing speed of left indoor pressure, stroke work index, total oxygen consumption index and total peripheral resistance, chamber, a prolongation left side begin to be contracted to left indoor pressure climbing speed time to peak, increase stroke volume, SI, coronary flow.This product is irritated stomach and is given spontaneous hypertensive rat (SHR), two kidneys, one folder type Hypertensive Rats (2K1C-RHR) 5.2,10.4,20.8g crude drug/kg, the result shows that each dosage group all can obviously reduce blood pressure and the heart rate of SHR, 2K1C-RHR and anesthesia SD rat (duodenal administration), alleviate the weight of SHR ventricle, reduction left ventricle weight/right ventricle is heavy, the ratio of heart weight/body weight, suppress left ventricle and aortic arch tube wall and thicken, reduce plasma renin activity and Angiotensin II level.The movable number of times of mice is obviously reduced, have obvious sedation.
Medicine of the present invention can obviously reduce the blood pressure and the heart rate of spontaneous hypertensive rat (SHR) and two kidneys, one folder type Hypertensive Rats, generally 1 hour blood pressure begins to descend after administration, the maximum reducing amplitude of two kinds of rats is respectively 26.3% and 26.4% approximately, and heavy dose can also delay the rise of blood pressure after the drug withdrawal.
Medicine of the present invention can reduce obviously that SHR rat left ventricle weight/right ventricle is heavy, the ratio of heart weight/body weight, makes left ventricle and the attenuation of aortic arch tube wall, shows that this product can improve the cardiac shape of SHR.
Medicine of the present invention can reduce the plasma renin activity and the Angiotensin II level of Hypertensive Rats, increases the renal artery blood flow amount, has the arteriorenal effect of expansion.
Medicine of the present invention (heavy dose of group 20.8g/kg, middle dosage group 10.4g/kg, small dose group 5.2g/kg) can significantly reduce the blood pressure and the heart rate of anesthetized rat, and heavy dose is organized 30min onset after administration, also has good hypotensive effect after administration in 2 hours.
Medicine of the present invention will suppress the spontaneous activity of MIH mice, has tangible sedation.
Medicine of the present invention when high dose hypotensive effect, to hemodynamic improvement effect, and reduce effects such as plasma renin activity and Angiotensin II level; action intensity is all similar to the niuhuang jiangya capsules group; but its onset time is slower, and can delay the rise of blood pressure after the drug withdrawal.
In sum, medicine of the present invention can significantly reduce the blood pressure of Canis familiaris L., clear-headed 2KIC-RHR and anesthesia SD rat, and coronary blood flow increasing and renal blood flow reduce myocardial oxygen consumption, improve heart, kidney form and hemodynamics, for the clinical trial of this medicine provides experimental data accurately and reliably.
Pharmic function of the present invention is that liver heat removing is let out fire, suppressing the hyperactive liver to relieve the wind syndrome.Be used for essential hypertension, disease is seen dizziness and headache, flushing conjunctival congestion, and being irritable and getting angry easily, dry mouth with bitter taste, constipation is urinated red, red tongue with yellow fur, wiry and frequent pulse etc., Chinese medical discrimination belongs to overabundant liver-fire syndrome.Poisonous side effect of medicine of the present invention is little, is difficult for producing drug resistance, and is evident in efficacy, with low cost, can satisfy patient's demand.
Claims (7)
1, the hypertensive oral Chinese medicine compositions of a kind of treatment is characterized in that it mainly is to be made by following bulk drugs: Spica Prunellae 15-30 part, Ramulus Uncariae Cum Uncis 15-25 part, Pheretima 15-25 part, Semen Cassiae 15-25 part.
2, the hypertensive oral Chinese medicine compositions of a kind of treatment according to claim 1 is characterized in that wherein the weight portion of each crude drug is Spica Prunellae 25-30 part, Ramulus Uncariae Cum Uncis 18-22 part, Pheretima 18-22 part, Semen Cassiae 18-22 part.
3, the hypertensive oral Chinese medicine compositions of a kind of treatment according to claim 1 is characterized in that wherein crude drug also has Radix Scutellariae 8-15 part.
4, the hypertensive oral Chinese medicine compositions of a kind of treatment according to claim 2 is characterized in that wherein weight portion 10-12 part of crude drug Radix Scutellariae.
5, the hypertensive oral Chinese medicine compositions of a kind of treatment according to claim 3 is characterized in that wherein crude drug also has Ramulus Et Folium Picrasmae 7-15 part, Plumula Nelumbinis 8-15 part.
6, the hypertensive oral Chinese medicine compositions of a kind of treatment according to claim 5 is characterized in that wherein the weight portion of each crude drug is Spica Prunellae 25-30 part, Ramulus Uncariae Cum Uncis 18-22 part, Pheretima 18-22 part, Semen Cassiae 18-22 part, Radix Scutellariae 10-12 part, Ramulus Et Folium Picrasmae 9-12 part, Plumula Nelumbinis 10-12 part.
7, the hypertensive oral Chinese medicine compositions of a kind of treatment according to claim 6 is characterized in that wherein the weight portion of each crude drug is 27 parts of Spica Prunellaes, 20 parts of Ramulus Uncariae Cum Uncis, 20 parts of Pheretimas, 20 parts of Semen Cassiaes, 11 parts of Radix Scutellariaes, 10 parts of Ramulus Et Folium Picrasmaes, 12 parts of Plumula Nelumbiniss.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100356506A CN1290536C (en) | 2004-09-06 | 2004-09-06 | Oral Chinese medicinal composition for treating hypertension |
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| CNB2004100356506A CN1290536C (en) | 2004-09-06 | 2004-09-06 | Oral Chinese medicinal composition for treating hypertension |
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| CN1657085A true CN1657085A (en) | 2005-08-24 |
| CN1290536C CN1290536C (en) | 2006-12-20 |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475780A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method 6 for traditional Chinese drug composition for treating primary hypertension |
| CN102475782A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method of traditional Chinese medicinal composition for treating primary hypertension |
| CN102475779A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method of traditional Chinese medicine composition for treating primary hypertension |
| CN102475783A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method 2 of traditional Chinese medicinal composition for treating primary hypertension |
| CN102475784A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Chinese medicinal composition for treating essential hypertension and its preparation method |
| CN102475785A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method of Chinese medicinal composition for treating essential hypertension |
| CN102475778A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method for traditional Chinese medicinal composition used for treating essential hypertension |
| CN102475781A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Method No.3 for preparing traditional Chinese medicine composition used for treating essential hypertension |
| CN102670785A (en) * | 2010-11-29 | 2012-09-19 | 天士力制药集团股份有限公司 | Preparation method of conventional Chinese medicine composition for treating primary hypertension |
| CN102688311A (en) * | 2012-06-26 | 2012-09-26 | 吉林大学珠海学院 | Traditional Chinese medicine compound preparation with blood pressure reducing function and preparation method thereof |
| CN104435781A (en) * | 2014-12-06 | 2015-03-25 | 郭亮 | Foot soaking liquid |
| CN107485686A (en) * | 2017-07-05 | 2017-12-19 | 庞世斌 | It is a kind of to treat the dizzy sick Chinese medicine composition of wind |
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2004
- 2004-09-06 CN CNB2004100356506A patent/CN1290536C/en not_active Expired - Fee Related
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102670785A (en) * | 2010-11-29 | 2012-09-19 | 天士力制药集团股份有限公司 | Preparation method of conventional Chinese medicine composition for treating primary hypertension |
| CN102475785B (en) * | 2010-11-29 | 2015-02-11 | 天士力制药集团股份有限公司 | Preparation method of Chinese medicinal composition for treating essential hypertension |
| CN102475780A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method 6 for traditional Chinese drug composition for treating primary hypertension |
| CN102475783A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method 2 of traditional Chinese medicinal composition for treating primary hypertension |
| CN102475784A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Chinese medicinal composition for treating essential hypertension and its preparation method |
| CN102475785A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method of Chinese medicinal composition for treating essential hypertension |
| CN102475778A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method for traditional Chinese medicinal composition used for treating essential hypertension |
| CN102475781A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Method No.3 for preparing traditional Chinese medicine composition used for treating essential hypertension |
| CN102475779A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method of traditional Chinese medicine composition for treating primary hypertension |
| CN102475779B (en) * | 2010-11-29 | 2015-04-01 | 天士力制药集团股份有限公司 | Preparation method of traditional Chinese medicine composition for treating primary hypertension |
| CN102475778B (en) * | 2010-11-29 | 2014-12-03 | 天士力制药集团股份有限公司 | Preparation method for traditional Chinese medicinal composition used for treating essential hypertension |
| CN102475781B (en) * | 2010-11-29 | 2014-09-17 | 天士力制药集团股份有限公司 | Method for preparing traditional Chinese medicine composition used for treating essential hypertension |
| CN102475782B (en) * | 2010-11-29 | 2015-02-11 | 天士力制药集团股份有限公司 | Preparation method of traditional Chinese medicinal composition for treating primary hypertension |
| CN102475782A (en) * | 2010-11-29 | 2012-05-30 | 天津天士力制药股份有限公司 | Preparation method of traditional Chinese medicinal composition for treating primary hypertension |
| CN102475784B (en) * | 2010-11-29 | 2015-04-01 | 天士力制药集团股份有限公司 | Chinese medicinal composition for treating essential hypertension and its preparation method |
| CN102670785B (en) * | 2010-11-29 | 2015-04-01 | 天士力制药集团股份有限公司 | Preparation method of conventional Chinese medicine composition for treating primary hypertension |
| CN102688311A (en) * | 2012-06-26 | 2012-09-26 | 吉林大学珠海学院 | Traditional Chinese medicine compound preparation with blood pressure reducing function and preparation method thereof |
| CN104435781A (en) * | 2014-12-06 | 2015-03-25 | 郭亮 | Foot soaking liquid |
| CN107485686A (en) * | 2017-07-05 | 2017-12-19 | 庞世斌 | It is a kind of to treat the dizzy sick Chinese medicine composition of wind |
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| CN1290536C (en) | 2006-12-20 |
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