CN1283275C - Chinese medicine for curing primary hypertension and its preparation method - Google Patents
Chinese medicine for curing primary hypertension and its preparation method Download PDFInfo
- Publication number
- CN1283275C CN1283275C CNB021496919A CN02149691A CN1283275C CN 1283275 C CN1283275 C CN 1283275C CN B021496919 A CNB021496919 A CN B021496919A CN 02149691 A CN02149691 A CN 02149691A CN 1283275 C CN1283275 C CN 1283275C
- Authority
- CN
- China
- Prior art keywords
- filter
- extract
- alcohol
- ethanol
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a medicament for treating hyperpiesia, which is prepared from traditional Chinese medicine comprising common selfheal fruit-spike, uncaria, earthworm, semen cassiae, baical skullcap root, quassia wood and lotus plumule as raw materials according to different characteristics of the traditional Chinese medicine through the procedures of extraction and encapsulation or tabletting so as to obtain capsules or tablets. The medicament has the functions for clearing away liver fire, suppressing hyperactive liver and calming endogenous wind and is mainly used for treating hyperpiesia with the symptoms of vertigo, headache, red face and eyes, precipitance, irritability, dry mouth, bitter taste in the mouth, constipation, red urine, red tongue with yellowish fur, stringlike pulse and the like, which belong to overabundant liver fire in the syndrome differentiation of traditional Chinese medicine. Pharmacodynamic experiments show that the medicament for treating hyperpiesia has obvious function for reducing blood pressure and has no toxic or side effects.
Description
Technical field
The present invention relates to the hyperpietic medicine of a kind of treatment, being specifically related to a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
Hypertension be a kind of agnogenic serve as the systemic disease of main performance with the systemic arterial pressure rising.Clinical with headache, dizziness, cardiopalmus, insomnia, weak be main clinical manifestation.End-stage patients can show various clinical symptoms because of internal organs such as the heart, brain, kidney appearance infringement in various degree.Its prevalence increases along with increasing of age.
950356 adults more than 15 years old of Chinese hypertension sample census in 1991 comprise 274 sampling crowds of 30 provinces, cities and autonomous regions (not containing port, Australia).Find hypertension prevalence 11.29%, wherein make a definite diagnosis hypertension (〉=160/95mmHg) 5.14%, I lithosphere hypertension (＜160/95mmHg, 〉=140/90nunHg) 6.15%, estimate that the whole nation has hypertensive patient 9,500 ten thousand approximately, and speed increase with annual 3500000 cases, with 7.73% compare in 1979, be significantly increased trend.
In the hypertension people, the borderline hypertension proportion is higher.Domestic borderline hypertension is followed up a case by regular visits to observed prognosis in 17 years, found 64.62% developing into and make a definite diagnosis hypertension wherein, and 21.53% patient recovers normally, had only 13.85% borderline hypertension still at critical level.Borderline hypertension patient's mortality rate is 2.35 times of normal person, and underlying cause of death is an apoplexy, and generation apoplexy and apoplexy death risk are respectively 8.34 times and 11.61 times of normal person.
Modern medicine thinks that hypertension has the Inheritance history, and many, the fatty intakes of the Sal amount of including in are many, drinks for a long time, long-term psychentonia, crowd's hypertension prevalence height such as smoking, overweight people.Most common complication is a cerebrovascular accident, secondly is the hypertensive heart disease heart failure, is renal failure again.The western medical treatment medicine is various, and commonly used have diuretic, vasodilation, adrenergic receptor blocker, nervus centralis and sympathetic inhibitor or the like.Most contraindication of these medicines and side effect are more, and patient easily produces drug resistance to multiple medicine, and wherein postural hypotension is clinical common side effect.In recent years, the medicine of Chinese medicine hypertension obtains exploitation and development more, but has the few in number of significant curative effect, and along with the sharp increase of hypertension number of patients, can not satisfy the needs of patient far away.
Summary of the invention
The object of the present invention is to provide a kind of is the medicine that can effectively treat hypertension that raw material is made with the Chinese herbal medicine, and this medicine has no side effect, taking convenience, and short treating period, evident in efficacy.
Another object of the present invention is to provide the preparation method of this medicine.
The medicine that is used for the treatment of hypertension provided by the invention is the medicament of being made by the following weight proportion raw material:
Spica Prunellae 1100g Ramulus Uncariae Cum Uncis 1250g Pheretima 900g Semen Cassiae 1100g
Radix Scutellariae 600g Ramulus Et Folium Picrasmae 450g Plumula Nelumbinis 400g.
The above-mentioned medicine that is used for the treatment of hypertension can be made said multiple dosage form on the pharmaceutics, as capsule, tablet or powder.
The above-mentioned preparation method that is used for the treatment of the medicine of hypertension may further comprise the steps:
(1) get Spica Prunellae 1100g, add 6 times of amount 90% alcohol reflux 3 times, each 1.5 hours, merge alcohol extract, filter, reclaim ethanol, drying under reduced pressure gets Spica Prunellae extract;
(2) hook taking rattan 1250g, Ramulus Et Folium Picrasmae 450g, Plumula Nelumbinis 400g, be ground into coarse powder, add 9 times of amount 80% ethanol, heating and refluxing extraction 2 times, 2.5 hours for the first time, 1.5 hours for the second time, merge alcohol extract, filter, reclaim ethanol and be concentrated into relative density 1.10-1.15, regulate pH to 2-3 with dilute hydrochloric acid, leave standstill, filter, acid liquid transfers to neutrality, adding ethanol makes and contains alcohol amount and reach 75%, leave standstill, filter, the alcoholic solution decompression recycling ethanol also is concentrated into relative density 1.30-1.35, drying under reduced pressure gets Ramulus Uncariae Cum Uncis, Ramulus Et Folium Picrasmae and Plumula Nelumbinis extract;
(3) get Radix Scutellariae 600g, decoct 2 times with 10 times, 8 times water gagings respectively, each 1 hour, filter, filtrate merges, and adds hydrochloric acid and transfers pH to 1.0-2.0, and 80 ℃ are incubated 30 minutes, the leaching precipitation, after adding a small amount of 50% washing with alcohol, 5 times of amounts of reuse washing with alcohol, drying under reduced pressure gets Radix Scutellariae extract;
(4) get Pheretima 900g, Semen Cassiae 1100g, be ground into coarse grain, add 8 times of water gagings and decoct 3 times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into relative density 1.10-1.15, adds ethanol and makes and contain alcohol amount and reach 75%, cold preservation 40 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.10-1.15, adds ethanol again and makes and contain the alcohol amount and reach 80%, cold preservation 24-72 hour, filter filtrate recycling ethanol, drying under reduced pressure gets Pheretima and Semen Cassiae extract;
(5) above-mentioned each extract is ground into fine powder, adds 6% soluble starch, mixing, filled capsules is made 1000, promptly gets capsule.
Medicine of the present invention has the effect that fire, suppressing the hyperactive liver to relieve the wind syndrome are let out in liver heat removing.Cure mainly essential hypertension, disease is seen dizziness and headache, flushing conjunctival congestion, and being irritable and getting angry easily, dry mouth with bitter taste, constipation is overflow red, red tongue with yellow fur, wiry and frequent pulse etc., Chinese medical discrimination belongs to overabundant liver-fire syndrome.Show to have the effect that significantly brings high blood pressure down through the test of pesticide effectiveness, have no side effect.
The invention will be further described below in conjunction with embodiment and pharmacodynamics test.
Embodiment 1
(1) get Spica Prunellae 1100g, add 6 times of amount 90% alcohol reflux 3 times, each 1.5 hours, merge alcohol extract, filter, reclaim ethanol, drying under reduced pressure gets Spica Prunellae extract;
(2) hook taking rattan 1250g, Ramulus Et Folium Picrasmae 450g, Plumula Nelumbinis 400g, be ground into coarse powder, add 9 times of amount 80% ethanol, heating and refluxing extraction secondary, 2.5 hours for the first time, 1.5 hours for the second time, merge alcohol extract, filter, reclaim ethanol and be concentrated into relative density 1.10～1.15 (50 ℃), regulate pH2-3 with dilute hydrochloric acid, leave standstill, filter, acid liquid transfers to neutrality, adding ethanol makes and contains alcohol amount and reach 75%, leave standstill, filter, the alcoholic solution decompression recycling ethanol also is concentrated into relative density 1.30～1.35 (60 ℃), drying under reduced pressure gets Ramulus Uncariae Cum Uncis, Ramulus Et Folium Picrasmae and Plumula Nelumbinis extract;
(3) get Radix Scutellariae 600g, decoct secondary with 10 times, 8 times water gagings respectively, each 1 hour, filter, filtrate merges, and adds 1.0～2.0,80 ℃ of insulations of hydrochloric acid adjust pH 30 minutes, the leaching precipitation, after adding a small amount of 50% washing with alcohol, 5 times of amounts of reuse washing with alcohol, drying under reduced pressure gets Radix Scutellariae extract;
(4) get Pheretima 900g, Semen Cassiae 1100g, be ground into coarse grain, add 8 times of water gagings and decoct 3 times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into relative density 1.10～1.15 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 75%, cold preservation 48 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.10～1.15 (50 ℃), adds ethanol again and makes and contain the alcohol amount and reach 80%, cold preservation 40 hours filters filtrate recycling ethanol, drying under reduced pressure gets Pheretima and Semen Cassiae extract;
(5) above-mentioned each extract is ground into fine powder, adds 6% soluble starch, mixing, filled capsules is made 1000, promptly gets capsule of the present invention.
Embodiment 2
(1) get Spica Prunellae 1200g, add 10 times of amount 80% alcohol reflux 3 times, each 2 hours, merge alcohol extract, filter, reclaim ethanol, drying under reduced pressure gets Spica Prunellae extract;
(2) hook taking rattan 1350g, Ramulus Et Folium Picrasmae 500g, Plumula Nelumbinis 500g, be ground into coarse powder, add 8 times of amount 90% ethanol, heating and refluxing extraction 3 times, the 1st time 2 hours, 2nd, be 1.5 hours 3 times, merge alcohol extract, filter, reclaim ethanol and be concentrated into relative density 1.10～1.15 (50 ℃), regulate pH2～3 with dilute hydrochloric acid, leave standstill, filter, acid liquid transfers to neutrality, adding ethanol makes and contains alcohol amount and reach 80%, leave standstill, filter, the alcoholic solution decompression recycling ethanol also is concentrated into relative density 130～1.35 (60 ℃), drying under reduced pressure gets Ramulus Uncariae Cum Uncis, Ramulus Et Folium Picrasmae and Plumula Nelumbinis extract;
(3) get Radix Scutellariae and decoct secondary with 10 times, 8 times water gagings respectively, each 1 hour, filter, filtrate merges, add 1.0～2.0,80 ℃ of hydrochloric acid adjust pHs insulation 30 minutes, the leaching precipitation, add a small amount of 50% washing with alcohol after, 5 times of amounts of reuse washing with alcohol, drying under reduced pressure promptly gets Radix Scutellariae extract;
(4) get Pheretima 1000g, Semen Cassiae 1100g, be ground into coarse grain, add 12 times of water gagings and decoct secondary, each 2 hours, collecting decoction filtered, filtrate is concentrated into relative density 1.10～1.15 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 70%, cold preservation 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.10～1.15 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach-85%, cold preservation 24 hours filters filtrate recycling ethanol, drying under reduced pressure gets Pheretima and Semen Cassiae extract;
(5) above-mentioned each extract is ground into fine powder, adds 10% soluble starch and 0.5% magnesium stearate, mixing, tabletting is made 1000, promptly gets tablet of the present invention.
Above embodiment is only for the present invention is further illustrated, and scope of the present invention is not subjected to the limitation of illustrated embodiment.
The present invention is to provide a kind of natural drug for the treatment of hypertension, for proving the effect of its treatment hypertension, the inventor uses the capsule for preparing by the method that provides in the foregoing description to carry out pharmacodynamics test, and result of study is as follows:
(1) capsule of the present invention (heavy dose of group 10.4g/kg, middle dosage group 5.2g/kg, small dose group 2.6g/kg) can obviously reduce the Canis familiaris L. systolic pressure, diastolic pressure and mean arterial pressure, reduce heart rate, cardiac output, cardiac index, prolong left ventricular pressure, chamber, left side diastasis pressure, the maximum climbing speed of left indoor pressure, stroke work index, total oxygen consumption index and total peripheral resistance, chamber, a left side begins to be contracted to left indoor pressure climbing speed time to peak, increase stroke volume, SI, coronary flow, prompting suppressing the hyperactive liver blood pressure decreasing capsule has remarkable coronary artery dilating blood flow, reduces the effect of myocardial oxygen consumption.
(2) capsule of the present invention can obviously reduce the blood pressure and the heart rate of spontaneous hypertensive rat (SHR) and two kidneys, one folder type Hypertensive Rats (2K1C-RHR), generally the 1w blood pressure begins to descend after administration, the maximum reducing amplitude of two kinds of rats is respectively 26.3% and 26.4% approximately, and heavy dose can also delay the rise of blood pressure after the drug withdrawal.
(3) capsule of the present invention can obviously reduce the ratio of SHR rat left ventricle weight/right ventricle weight, heart weight/body weight, makes left ventricle and the attenuation of aortic arch tube wall, shows that the suppressing the hyperactive liver blood pressure decreasing capsule can improve the cardiac shape of SHR.
(4) capsule of the present invention can reduce the plasma renin activity and the Angiotensin II level of Hypertensive Rats, increases the renal artery blood flow amount, has the arteriorenal effect of expansion.
(5) capsule capsule of the present invention (heavy dose of group 20.8g/kg, middle dosage group 10.4g/kg, small dose group 5.2g/kg) can significantly reduce the blood pressure and the heart rate of anesthetized rat, heavy dose is organized 30min onset after administration, and 2h also has good hypotensive effect after administration.
(6) capsule of the present invention can suppress the spontaneous activity of MIH mice, has tangible sedation.
(7) capsule of the present invention when high dose hypotensive effect, to hemodynamic improvement effect, and reduce effects such as plasma renin activity and Angiotensin II level; action intensity is all similar to the niuhuang jiangya capsules group; but its onset time is slower, and can delay the rise of blood pressure after the drug withdrawal.
Claims (3)
1, the hyperpietic medicine of a kind of treatment is characterized in that it is made by the following weight proportion raw material:
Spica Prunellae 1100g Ramulus Uncariae Cum Uncis 1250g Pheretima 900g Semen Cassiae 1100g
Radix Scutellariae 600g Ramulus Et Folium Picrasmae 450g Plumula Nelumbinis 400g.
2, the hyperpietic medicine of treatment according to claim 1, the dosage form that it is characterized in that this medicine is a capsule.
3, the preparation method of the hyperpietic medicine of the described treatment of claim 2 may further comprise the steps:
(1) get Spica Prunellae 1100g, add 6 times of amount 90% alcohol reflux 3 times, each 1.5 hours, merge alcohol extract, filter, reclaim ethanol, drying under reduced pressure gets Spica Prunellae extract;
(2) hook taking rattan 1250g, Ramulus Et Folium Picrasmae 450g, Plumula Nelumbinis 400g, be ground into coarse powder, add 9 times of amount 80% ethanol, heating and refluxing extraction 2 times, 2.5 hours for the first time, 1.5 hours for the second time, merge alcohol extract, filter, reclaim ethanol and be concentrated into relative density 1.10-1.15, regulate pH to 2-3 with dilute hydrochloric acid, leave standstill, filter, acid liquid transfers to neutrality, adds ethanol and makes and contain the alcohol amount and reach 75%, leave standstill, filter, the alcoholic solution decompression recycling ethanol also is concentrated into relative density 1.30-1.35, and drying under reduced pressure gets Ramulus Uncariae Cum Uncis, Ramulus Et Folium Picrasmae and Plumula Nelumbinis extract;
(3) get Radix Scutellariae 600g, decoct 2 times with 10 times, 8 times water gagings respectively, each 1 hour, filter, filtrate merges, and adds hydrochloric acid and transfers pH to 1.0-2.0, and 80 ℃ are incubated 30 minutes, the leaching precipitation, after adding a small amount of 50% washing with alcohol, 5 times of amounts of reuse washing with alcohol, drying under reduced pressure gets Radix Scutellariae extract;
(4) get Pheretima 900g, Semen Cassiae 1100g, be ground into coarse grain, add 8 times of water gagings and decoct 3 times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into relative density 1.10-1.15, adds ethanol and makes and contain alcohol amount and reach 75%, cold preservation 40 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.10-1.15, adds ethanol again and makes and contain the alcohol amount and reach 80%, cold preservation 24-72 hour, filter filtrate recycling ethanol, drying under reduced pressure gets Pheretima and Semen Cassiae extract;
(5) above-mentioned each extract is ground into fine powder, adds 6% soluble starch, mixing, filled capsules is made 1000, promptly gets capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021496919A CN1283275C (en) | 2002-12-20 | 2002-12-20 | Chinese medicine for curing primary hypertension and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021496919A CN1283275C (en) | 2002-12-20 | 2002-12-20 | Chinese medicine for curing primary hypertension and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1428171A CN1428171A (en) | 2003-07-09 |
| CN1283275C true CN1283275C (en) | 2006-11-08 |
Family
ID=4751719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021496919A Expired - Fee Related CN1283275C (en) | 2002-12-20 | 2002-12-20 | Chinese medicine for curing primary hypertension and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1283275C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362785A (en) * | 2015-12-17 | 2016-03-02 | 武明霞 | Medicine composition for treating primary hypertension and preparation method thereof |
-
2002
- 2002-12-20 CN CNB021496919A patent/CN1283275C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1428171A (en) | 2003-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100366280C (en) | Medicinal composition for treating hypertension, its preparation method and use | |
| CN101849957B (en) | Application of Dendrobium officinale polysaccharide in preparation of medicine for preventing and treating hypertension and apoplexy | |
| CN106421359A (en) | Medicine composition for comprehensively treating diabetes and complications thereof | |
| CN1290536C (en) | Oral Chinese medicinal composition for treating hypertension | |
| CN102579669A (en) | Chinese medicinal composition for nourishing qi and blood and conditioning menstruation and preparation method thereof | |
| CN102423420A (en) | Traditional Chinese medicine combination for vision rehabilitation and preparation method thereof | |
| CN102631526B (en) | Chinese medicinal composition for treating diabetes mellitus | |
| CN103893284A (en) | Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use | |
| CN1283275C (en) | Chinese medicine for curing primary hypertension and its preparation method | |
| CN102671060A (en) | Medicinal composition for treating gout and preparation method thereof | |
| CN102344880B (en) | Health wine and production method thereof | |
| CN104721467B (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof | |
| CN105998651A (en) | Compound traditional Chinese medicine composition for treating hypertension and preparation method thereof | |
| CN111419999B (en) | Traditional Chinese medicine composition for treating hyperuricemia and preparation method thereof | |
| CN102727627B (en) | Traditional Chinese medicine composition for treating heart failure and preparation method and application thereof | |
| CN102068585A (en) | Chinese medicinal compound preparation for treating chronic nephritis and nephrotic syndromes | |
| CN105560911B (en) | A kind of Chinese medicine and preparation method thereof for treating hypertension | |
| CN104173681B (en) | Traditional Chinese herbal medicine composition for treating castration-resistant prostate cancer | |
| CN107158268A (en) | It is a kind of to treat Chinese medicine composition of hypertension and its preparation method and application | |
| CN110841037B (en) | Traditional Chinese medicine medicament for treating circadian rhythm disorder sleep disorder and preparation method thereof | |
| CN100435842C (en) | Chinese-medicinal preparation for treating hypertension and its making method | |
| CN110721217A (en) | Preparation method of tablet for treating hypertension | |
| CN1290531C (en) | Chinese traditional medicine for treating allergic rhinitis | |
| CN106692313A (en) | Caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii consciousness restoring composition, caulis piperis kadsurae-caulis sargentodoxae-caulis sinomenii medicinal preparation and application thereof | |
| CN100453098C (en) | Medicine for treating chronic renal insufficiency and its prepn. method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |