CN100435842C - Chinese-medicinal preparation for treating hypertension and its making method - Google Patents
Chinese-medicinal preparation for treating hypertension and its making method Download PDFInfo
- Publication number
- CN100435842C CN100435842C CNB2006100868467A CN200610086846A CN100435842C CN 100435842 C CN100435842 C CN 100435842C CN B2006100868467 A CNB2006100868467 A CN B2006100868467A CN 200610086846 A CN200610086846 A CN 200610086846A CN 100435842 C CN100435842 C CN 100435842C
- Authority
- CN
- China
- Prior art keywords
- add
- filtrate
- preparation
- chinese medicine
- radix ginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for treating hypertension, dizziness and insomnia is prepared from 6 Chinese-medicinal materials including evodia fruit, ginseng, alismatis rhizome, ginger, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of hypertension and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Hypertension is modal cardiovascular disease, and its number of patients is numerous, accounts for 42.5% of total death toll, is the mankind's first killer, and its main clinical manifestation is hypertension.Hypertension belongs to chronic disease, and at present, hypertension incidence has two main trend: the one, and sickness rate rises, and lapses to seriously, finally dies from cardiovascular and cerebrovascular disease and renal failure more; The 2nd, age of onset reduces, and young and middle-aged patient increases.The prevention of hypertension has become one of most important global problem in the cardiovascular field with treatment.
At present, the types of drugs of domestic and international application western medicine high blood pressure disease is more, upgrades very fast, but along with clinical and experimental study deepen continuously, find that these medicines have the some shortcomings of himself, gentle inadequately as the effect of medicine, it is more that the scope of effect too extensively reaches side effect.Along with improving constantly of living standard, people are the uphold nature therapy more, and the quality and quantity of health care is had higher requirement.Therefore, the medicine of life-time service of seeking the treatment hypertension of new high-efficiency low-toxicity is very necessary.Through secular clinical practice, Chinese medicine has accumulated rich experience in the theoretic knowledge that has formed own uniqueness aspect the treatment hypertension.We have carried out in depth inquiring into to hypertensive occurrence regularity, think yin and yang imbalance, and expectorant is turbid generally, is its basic pathogenesis, has only to examine because of opinion and controls, and could improve curative effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of hypertension and preparation method thereof, to solve the problem that prior art exists.
Purpose of the present invention realizes by following embodiment:
The Chinese medicine preparation of treatment hypertension of the present invention calculates according to components by weight percent, by Fructus Evodiae 3-12 part, and Radix Ginseng 3-12 part, Rhizoma Alismatis 3-12 part, Cortex Eucommiae 10-20 part, Rhizoma Zingiberis Recens 2-15 part and Fructus Jujubae 5-20 part and an amount of adjuvant are prepared from.
Preferably, Chinese medicine preparation of the present invention Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g, Rhizoma Zingiberis Recens 5g, Cortex Eucommiae 15g, Fructus Jujubae 7g add the appropriate amount of auxiliary materials preparation after extracting.
Effervescent granule), capsule preparations (containing: hard capsule preparation, soft capsule preparation), tablet (containing: effervescent tablet, dispersible tablet, controlled release tablet, slow releasing tablet, oral cavity disintegration tablet, chewable tablet, sublingual lozenge) or pill (containing: pellet preparations, dropping pill formulation), oral liquid formulations described Chinese medicine preparation can be made granular preparation and (contain:.
The preparation method of the Chinese medicine preparation of described treatment hypertension is: weighting raw materials material Fructus Evodiae, Radix Ginseng and Rhizoma Alismatis, ethanol extraction 1-5 time that Fructus Evodiae, Radix Ginseng and the Rhizoma Alismatis of described weight proportion is added the 50-80% (v/v) of 8-20 times of weight every 1-2 hour, filters, get filtrate A, standby; Take by weighing ginger slice, the Cortex Eucommiae and Fructus Jujubae that thickness is the 1-8 millimeter, ginger slice, the Cortex Eucommiae and the Fructus Jujubae of described weight proportion added 8-20 times of weight water, extraction time 1-4 hour, carry 1-4 time altogether, collecting decoction filters, filtrate is concentrated into the clear paste of certain relative density, puts coldly, adds ethanol and makes medicinal liquid contain alcohol amount to be 50-80% (w/w), left standstill 10-24 hour, and filtered, get liquor B, filtrate A and liquor B are merged, reclaim ethanol and be concentrated into the thick paste of certain density, drying is ground into fine powder; Add right amount of auxiliary materials, be prepared into the preparation that needs.
Preferred manufacturing procedure of the present invention is: weighting raw materials Fructus Evodiae 9g, Radix Ginseng 9g and Rhizoma Alismatis 9g add ethanol extraction 1-5 time of the 50-80% (v/v) of 8-20 times of weight, every 1-2 hour, filter, filtrate A, standby; Add 8-20 times of weight water with being cut into ginger slice 5g, Cortex Eucommiae 15g and the Fructus Jujubae 7g that thickness is the 1-3 millimeter, extraction time 1-4 hour, carry 1-4 time altogether, collecting decoction filters, and filtrate is concentrated into the clear paste of certain relative density, put coldly, add ethanol and make medicinal liquid contain alcohol amount to be 50-80% (w/w), to leave standstill 10-24 hour, filter, liquor B, filtrate A and liquor B are merged, recovery ethanol also is concentrated into the thick paste of certain density, drying is ground into fine powder; Add right amount of auxiliary materials, mixing is made granule 1000g, promptly gets granule.
The adjuvant that uses in the Chinese medicine preparation of the present invention is the conventional adjuvant in the field of traditional Chinese medicine pharmacy, the concrete kind of adjuvant and use amount are determined according to concrete dosage form, the dosage form that those of ordinary skill in the art prepares is as required determined the adjuvant and the consumption thereof that use easily.
Chinese medicine preparation of the present invention has the liver of accent and rushes down turbid, the effect that blood pressure lowering consolidates, be mainly used in yin and yang imbalance, expectorant is turbid general, diseases such as the dizzy headache that the cloudy expectorant of fainting is turbid, insomnia are usually used in the treatment of hypertension, compared with prior art, its toxic and side effects is little, therapeutic effect good and the preparation is simple, takes, easy to carry.
The present invention is to be monarch drug with the Fructus Evodiae, simultaneously in conjunction with the pathology of hypertension, the characteristics of pathogenesis, is equipped with that to transfer liver to rush down turbid, the common prescription of forming of the Chinese medicine that blood pressure lowering consolidates.
Be monarch drug with the Fructus Evodiae in the side: the Fructus Evodiae bitter in the mouth is warm in nature, returns liver, spleen, stomach, kidney channel, has the merit of dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.On function, it is hot to rise hardship and falls, the lifting mechanism of qi, soothing the liver dissipating depression of QI, again property belong to scorching, but warming spleen and stomach for dispelling cold, drying dampness to eliminate phlegm, and its property is descending and diffusing can the therapeutic method to keep the adverse QI flowing downwards be put down and is dashed, the turbid descending is non-return, Wen Huatong falls.Modern pharmacology studies confirm that, pharmacological action such as Fructus Evodiae has analgesia, calms the nerves, antibiotic, blood pressure lowering and antioxidation.And one of Fructus Evodiae Guizhou five big famous medicines, thus take for monarch drug.
Being equipped with Radix Ginseng in the side is ministerial drug: Radix Ginseng sweet and slightly bitter taste, slightly warm in nature have the merit of QI invigorating tonify deficiency.On function, how sweet its nature and flavor are, can the tonification qi of zang-fu viscera.Modern pharmacology discovers that Radix Ginseng has shock, blood sugar lowering, effects such as enhancing human body immunity function.Compatible with Fructus Evodiae in the side, the effect of QI invigorating tonify deficiency is arranged, and strengthen Fructus Evodiae Wen Huatong and fall, train the merit of first blood pressure lowering, so be ministerial drug.
With Rhizoma Alismatis, the Cortex Eucommiae, Rhizoma Zingiberis Recens is adjuvant drug altogether: cold in nature because of Rhizoma Alismatis, slightly sweet flavor has promoting diuresis to eliminate damp pathogen, the effect of purging heat; The Cortex Eucommiae, sweet in the mouth warm in nature is returned liver, kidney channel, energy invigorating the liver and kidney, strengthing aitch bone; Rhizoma Zingiberis Recens, little suffering of distinguishing the flavor of, tool warming spleen and stomach for dispelling cold, the merit of warming the lung to relieve cough.Three flavors are got the turbid dampness removing of rushing down of Rhizoma Alismatis in fact for adjuvant drug, the tonifying kidney blood pressure lowering of the Cortex Eucommiae, and the merit of Rhizoma Zingiberis Recens warming middle-JIAO to send down the adverse QI helps the power of Fructus Evodiae blood pressure lowering altogether.
With Fructus Jujubae is messenger drug: Fructus Jujubae sweet in the mouth warm in nature, can relax the property of medicine, have harmonizing the spleen and stomach, the merit of coordinating the actions of various ingredients in a prescription, and with it for making, the merit of the ginseng invigorating the spleen and benefiting QI tonify deficiency of can helping others.
Make a general survey of full side, have the benefit of accent and rush down the turbid characteristics that combine, embodied pathogenesis ' void ', ' expectorant ', ' contrary ' of Chinese traditional treatment hypertension, void is taste, also double kidney void, expectorant (wetting) be expectorant (wetting) turbid in resistance, ' contrary ' is imbalance of YIN and YANG, liver is lost bar and reaches, and mechanism of qi is disorderly contrary, and the rule of treatment " treatment should be with ' holding up soil to press down wood; flat contrary consolidating '; hold up soil be exactly spleen reinforcing empty to remove spleen wet, specifically be exactly that to transfer liver to rush down turbid, consolidate blood pressure lowering ".So can treat yin and yang imbalance effectively, expectorant is turbid general, the turbid hypertension that causes of the cloudy expectorant of fainting.
Mainly contain compositions such as volatile oil, alkaloid in the Fructus Evodiae, the main component rutaecarpin in its alkaloid, rutaecarpine have analgesia, blood pressure lowering and etc. pharmacological action.
Radix Ginseng mainly contains compositions such as saponin, polysaccharide, trace element.Wherein the ginsenoside is the Radix Ginseng main active, is usually used in the deficiency of vital energy and desires to take off, faint pulse being about to disappear, insufficiency of lung-QI, deficiency of qi and blood, syndrome of deficiency of blood etc.
Rhizoma Alismatis mainly contains liposoluble constituents such as triterpenes, sesquiterpenoids and diterpene-kind compound, and modern pharmacological research shows that Rhizoma Alismatis has effects such as the arteriosclerosis of inhibition, blood fat reducing, diuresis, blood pressure lowering, anti-fatty liver; Simultaneously, a large amount of modern clinical datas show that also Rhizoma Alismatis and compound recipe thereof have all been obtained good curative effect in the treatment of commonly encountered diseases such as hypertension, hyperlipidemia.
The main effective ingredient of Rhizoma Zingiberis Recens is compositions such as volatile oil, gingerol, Diphenylheptane.Has relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, the merit of warming the lung to relieve cough.
The Cortex Eucommiae mainly contains compositions such as alkaloid, lignanoid, iridoids, flavonoid, and wherein pinoresinol diglucoside and Flos Caryophylli fat diglucoside have tangible hypotensive effect; Ivioden-drin, Asperoside and syringaresinol are the inhibitor of angiotensin and ring gland former times acid (CAMP), thus can blood vessel dilating, coronary blood flow increasing.The modern pharmacology test has proved that also Cortex Eucommiae water extract has tangible hypotensive effect to dog, and stable curative effect, has no side effect.
Fructus Jujubae contains water soluble ingredients such as flavonoid, several amino acids, saccharide.The Fructus Jujubae decoct can improve the mice body weight, prolong the load swimming time, and the composition of the flavonoid that it is contained has calmness, hypnosis, hypotensive activity significantly.
For finishing the present invention, we use Fructus Evodiae preparation extract of the present invention (that is: the embodiment of the invention 1 prepare compound extract of the present invention) to carry out a series of experimentation, and its result is as follows:
Pharmacology, toxicity part:
Main pharmacodynamics research:
The result of the test that influences to normal rat blood pressure and heart rate shows:
Behind duodenal administration, 30min is the obvious hypotensive effect of tool after (2.0g/kg) administration of the heavy dose of group of Fructus Evodiae preparation extract, 60min produces ceiling effect, the rat normal contraction is pressed and diastolic pressure descends 17% and 20% respectively, with relatively have significant difference (P＜0.05 before the administration, P＜0.01), blood pressure lowering can make decreased heart rate simultaneously, with relatively there were significant differences (P＜0.05) before the administration.Also obviously blood pressure lowering of 45min after middle dosage group (1.0g/kg) administration, 90min produces ceiling effect, and SAP and DAP reduce by 19% and 14% respectively, with comparing difference before the administration remarkable (P＜0.05, P＜0.01), more than the hypotensive effect persistent period 4h.The effect of dosage compound Herba Apocyni veneti (Folium Apocyni Veneti) group is similar to waiting.HR there is not obvious influence.
The result of the test that influences to clear-headed renal hypertensive rat blood pressure shows:
Give Fructus Evodiae preparation extract through irritating stomach: compare significant difference (P＜0.05) before the effect of heavy dose of group (2.0g/kg) reduction systolic pressure and diastolic pressure and the administration; In dosage group (1.0g/kg) administration promptly saw obvious pressure reduction effect the same day, systolic pressure and diastolic pressure relatively are respectively 25% and 35% before reducing amplitude and medicine, significant difference (P＜0.01), the reduction effect of systolic pressure is similar to group such as compound Herba Apocyni veneti (Folium Apocyni Veneti) such as dosage such as grade, diastolic pressure reduces effect and is better than the compound Herba Apocyni veneti (Folium Apocyni Veneti) group, and should organize drug withdrawal 9 days, before the blood pressure group does not return back to administration; Each group does not all have tangible influence to clear-headed renal hypertensive rat heart rate.
Analgesic activity is observed:
The result of the test that influences that the mice hot plate is caused pain shows, Fructus Evodiae preparation extract heavy dose is organized no matter administration 3 days or 6 days, all can prolong hot plate and cause the time that mice licks metapedes, significantly improves (P＜0.05) with blank group comparison pain threshold.Mice acetic acid is caused the result of the test that influences bitterly show, the heavy dose of group of Fructus Evodiae preparation extract obviously reduces the mouse writhing reaction times that glacial acetic acid causes pain with middle dosage group, with blank group comparing difference remarkable (P＜0.05).
The sedative-hypnotic effect viewing test:
The result of the test that influences to mice pentobarbital sodium subliminal hypnosis amount shows that Fructus Evodiae preparation extract three dosage groups single or successive administration 3 days do not have influence to the sub-threshold dose pentobarbital sodium to the syngignoscism of mice.Viewing test result to mice pentobarbital sodium hypnosis amount shows, successive administration 3 days, Fructus Evodiae preparation extract small dose group has synergism to the mice sleep that the HD pentobarbital sodium causes, compares mice sleep persistent period significant prolongation (P＜0.05) with the blank group.
Influence test to spontaneous activity in mice shows:
Successive administration 3 days, Fructus Evodiae preparation extract small dose group can make spontaneous activity in mice obviously reduce, with blank significant difference (P＜0.05).
Results of pharmacodynamic test shows: make the rat decreased heart rate when can reduce normal (anesthesia) rat blood pressure (SAP and DAP), blood pressure lowering; To clear-headed renal hypertensive rat blood pressure lowering (SAP and DAP) effect significantly and stablize, especially in dosage group, reduction DAP effect more stable than the effect of isodose depressor compound Herba Apocyni veneti (Folium Apocyni Veneti), drug withdrawal still kept original blood pressure lowering drug effect in 9 days.This drug efficacy study also confirms: this medicine can improve mice causes pain to hot plate pain threshold, suppress the writhing response that acetic acid causes, the mice prolonged sleep time that the pentobarbital sodium of prolongation HD causes, reduce the number of times of spontaneous activity in mice, illustrate that this medicine has certain assosting effect to the symptom of alleviating hypertension.
This result of study shows: compound recipe Fructus Evodiae preparation antihypertensive effect of the present invention is obviously stablized, and has excellent development prospect and clinical value.
Studies on acute toxicity:
This product is with Cmax (60%), maximum volume (0.5ml/10g/ day) divided 2 filling stomaches (0.25ml/10g/ time) in 24 hours after, observed 7 days continuously, as a result, 40 experiment mices are not seen dead and obvious poisoning manifestations, and body weight significantly increases (P＜0.001) after 7 days, this product clinical consumption of being grown up is: 8g extract powder/day, every mouse tolerance dose is: 0.614g, and mice average weight: 20.45g, the mice maximum tolerated dose is as calculated: 187.5 times.
The pharmacy part:
Determining on the basis of consulting domestic and international Chinese medicine modern study document of formulation and technology route of the present invention, according to the function of this prescription cure mainly and write out a prescription in the physicochemical property of the contained effective ingredient of each medicine, formulated preparation technology with alcohol extraction+water extract-alcohol precipitation.And it is preferred that this technology is carried out orthogonal test:
1, alcohol extraction process: take by weighing Fructus Evodiae, Radix Ginseng, Rhizoma Alismatis medical material respectively in the prescription ratio, by orthogonal table L
9(3
4) carry out preferably.Total amount with the Fructus Evodiae total alkali is an index, concentration of alcohol, ethanol consumption, extraction time, four factors of extraction time has been carried out optimizing investigated, and optimizes best alcohol extraction process.
2, aqueous extraction-alcohol precipitation technology: take by weighing the Cortex Eucommiae, Fructus Jujubae, ginger slice respectively in the prescription ratio, by orthogonal table L
9(3
4) carry out orthogonal test, be that index has carried out optimizing investigation to amount of water, decocting time, three factors of decoction number of times with the chlorogenic acid total amount, optimize best decocting and boil technology; In order to remove invalid components in the Chinese traditional medicine water extract to greatest extent, keep effective ingredient as much as possible, the prescription ratio takes by weighing the Cortex Eucommiae, Fructus Jujubae, ginger slice respectively, boils the optimum condition extraction that technology is determined by above-mentioned decocting, after extracting solution is concentrated into corresponding density, by orthogonal table L
9(3
4) to carry out orthogonal test be index with the chlorogenic acid total amount, extractum relative density, two factors of precipitate with ethanol condition are carried out preferably optimizing best alcohol precipitation process.Carried out the selection of method of granulating at last, the determining of adjuvant type and consumption, and measure making particulate physical property, determined preparation prescription and method for making, simple for process, workable through pilot scale scale-up proof, adapt to big requirement of producing.
According to " relevant requirements under an appendix IC of Chinese pharmacopoeia version in 2005 the granule item and the regulation of " medicine registration management way ", and carried out the lot of documents retrieval, formulated clinical trial of the present invention on this basis with drug standard (draft) and draft explanation.
Adopt thin layer chromatography that Radix Ginseng, Rhizoma Alismatis, Fructus Evodiae, Fructus Jujubae in this product have been carried out qualitative identification, serve as that Fructus Evodiae is differentiated in contrast wherein with rutaecarpin and rutaecarpine reference substance, with the oleanolic acid reference substance serves as that Fructus Jujubae is differentiated in contrast, with Radix Ginseng control medicinal material, ginsenoside Rb1, ginsenoside Rg1, ginsenoside Re's reference substance serves as that Radix Ginseng is differentiated in contrast, serves as that Rhizoma Alismatis is differentiated in contrast with the Rhizoma Alismatis control medicinal material.The result show three batch samples (lot number is respectively: 050301,050302,050303) all with reference substance or the corresponding position of control medicinal material chromatograph on show the speckle or the fluorescence speckle of same color, feminine gender is all noiseless.
With reference to " the method for assay under the 118th page of Fructus Evodiae item of Chinese pharmacopoeia version in 2005, and with reference to high performance liquid chromatography " appendix VID of Chinese pharmacopoeia version in 2005, content to the Fructus Evodiae total alkali in this product is measured, (lot number is respectively: 050301 through methodology system thinking and three batch samples, 050302,050303) assay, rutaecarpin and rutaecarpine and other component separating are good in this product, rutaecarpine is at 0.3280～1.640ug, rutaecarpin 0.2360～1.180ug scope internal linear is good, the average average recovery of rutaecarpin is 101.19%, RSD=1.01%; The average average recovery of rutaecarpine is 101.19%, RSD=1.31%.The result shows: the method is easy, quick, exclusive, sensitive, accurate.Every index of having determined this granule simultaneously all meets " the pertinent regulations under an appendix IC of Chinese pharmacopoeia version in 2005 the granule item.
The result shows: the stable easily row of this standard, and controllability is strong, and good reproducibility can be controlled the quality of this product.
Result of study by above pharmacy part shows: technology of the present invention is rationally feasible, and is stable and controllable for quality.
The specific embodiment:
Further specify the present invention below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate the present invention rather than limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.In addition, in the present invention, (v/v) expression volume by volume concentration or volume ratio; (w/w) expression weight ratio concentration or weight ratio; (min) expression minute.Except as otherwise noted, percent of the present invention is percetage by weight.
Embodiment 1: prepare compound extract of the present invention and granule thereof
Weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g add the ethanol extraction secondary of 10 times of weight 70% (v/v) with the Fructus Evodiae of described weight proportion, Radix Ginseng, Rhizoma Alismatis three flavors, each 1.5 hours, filter, merging filtrate, filtrate A is standby; Taking by weighing thickness is ginger slice 5g, Cortex Eucommiae 15g, the Fructus Jujubae 7g of 2mm, with the thickness of described weight proportion is that ginger slice, the Cortex Eucommiae, the Fructus Jujubae of 2mm adds 10 times of weight decoctings and boil secondary, each 1.5 hours, collecting decoction, filter, it is 1.05-1.10 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain the alcohol amount be 70% (w/w), standing over night filters, get liquor B, liquor B and filtrate A are merged, and surveying relative density when reclaiming ethanol and being concentrated into 60 ℃ is the thick paste of 1.20-1.25, drying under reduced pressure, be ground into fine powder, obtain compound extract of the present invention; Add dextrin, Icing Sugar is an amount of, mixing, and drying and granulating is made granule 1000g, promptly gets granule.This product boiled water is taken after mixing it with water, one time one bag, three times on the one.
Embodiment 2: prepare compound extract of the present invention and capsule thereof
Weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g add the ethanol extraction secondary of 10 times of weight 70% (v/v) with the Fructus Evodiae of described weight proportion, Radix Ginseng, Rhizoma Alismatis three flavors, each 1.5 hours, filter, merging filtrate, filtrate A, standby; Taking by weighing thickness is the ginger slice 5g of 2mm, Cortex Eucommiae 15g, Fructus Jujubae 7g, with the thickness of described weight proportion is the ginger slice of 2mm, the Cortex Eucommiae, Fructus Jujubae adds 10 times of weight decoctings and boils secondary, each 1.5 hours, collecting decoction filters, and it is 1.05-1.10 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain the alcohol amount be 70% (w/w), standing over night filters, and gets liquor B, liquor B and filtrate A are merged, surveying relative density when reclaiming ethanol and being concentrated into 60 ℃ is the thick paste of 1.20-1.25, and drying is ground into fine powder or adds an amount of sodium carboxymethyl cellulose, add the moistening granulation of water, mixing incapsulates, and promptly gets capsule.
Embodiment 3: prepare compound extract of the present invention and tablet thereof
Weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g add the ethanol extraction secondary of 10 times of weight 70% (v/v) with the Fructus Evodiae of described weight proportion, Radix Ginseng, Rhizoma Alismatis three flavors, each 1.5 hours, filter, merging filtrate, filtrate A, standby; Taking by weighing thickness is ginger slice 5g, Cortex Eucommiae 15g, the Fructus Jujubae 7g of 2mm, with the thickness of described weight proportion is that ginger slice, the Cortex Eucommiae, the Fructus Jujubae of 2mm adds 10 times of weight decoctings and boil secondary, each 1.5 hours, collecting decoction, filter, it is 1.05-1.10 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain the alcohol amount be 70% (w/w), standing over night filters, and gets liquor B, liquor B and filtrate A are merged, surveying relative density when reclaiming ethanol and being concentrated into 60 ℃ is the thick paste of 1.20-1.25, and drying is ground into fine powder; Add an amount of sodium carboxymethyl cellulose, add the moistening granulation of water, drying, tabletting promptly gets tablet.
Embodiment 4: prepare compound extract of the present invention and oral liquid thereof
Weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g add the ethanol extraction secondary of 10 times of weight 70% (v/v) with the Fructus Evodiae of described weight proportion, Radix Ginseng, Rhizoma Alismatis three flavors, each 1.5 hours, filter, merging filtrate, filtrate A, standby; Taking by weighing thickness is ginger slice 5g, Cortex Eucommiae 15g, the Fructus Jujubae 7g of 2mm, with the thickness of described weight proportion is that ginger slice, the Cortex Eucommiae, the Fructus Jujubae of 2mm adds 10 times of weight decoctings and boil secondary, each 1.5 hours, collecting decoction filtered, it is 1.05-1.10 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain the alcohol amount be 70% (w/w), standing over night filters, get liquor B, liquor B and filtrate A are merged, and recovery ethanol also is concentrated in right amount, and adding antiseptic and the tender agent of distinguishing the flavor of are an amount of, regulate total amount to 1000ml, stir evenly, filter fill, sterilization promptly gets oral liquid.
Embodiment 5: prepare compound extract of the present invention and soft capsule preparation thereof
Weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g add the ethanol extraction secondary of 10 times of weight 70% (v/v) with the Fructus Evodiae of described weight proportion, Radix Ginseng, Rhizoma Alismatis three flavors, each 1.5 hours, filter, merging filtrate, filtrate A, standby; Taking by weighing thickness is ginger slice 5g, Cortex Eucommiae 15g, the Fructus Jujubae 7g of 2mm, with the thickness of described weight proportion is that ginger slice, the Cortex Eucommiae, the Fructus Jujubae of 2mm adds 10 times of weight decoctings and boil secondary, each 1.5 hours, collecting decoction, filter, it is 1.05-1.10 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain the alcohol amount be 70% (w/w), standing over night filters, and gets liquor B, liquor B and filtrate A are merged, surveying relative density when reclaiming ethanol and being concentrated into 60 ℃ is the thick paste of 1.20-1.25, and drying under reduced pressure is ground into fine powder; Add the diluent that vegetable oil and Cera Flava are formed, grind well, standby; It is standby that other gets gelatin solution (100 parts in gelatin, 50 parts of glycerol, 120 parts in water); Under the condition of 23 ± 2 ℃ of room temperatures, relative humidity 40%, medicinal liquid and gelatin solution are pressed into soft capsule, promptly get soft capsule preparation, and vegetable oil can be one or more the miscella in soybean oil, Oleum Arachidis hypogaeae semen, the Oleum Camelliae; Also vegetable oil can be used instead and be PEG400.
Embodiment 6: prepare compound extract of the present invention and drop pill thereof
Weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g add the ethanol extraction secondary of 10 times of weight 70% (v/v) with the Fructus Evodiae of described weight proportion, Radix Ginseng, Rhizoma Alismatis three flavors, each 1.5 hours, filter, merging filtrate, filtrate A, standby; Taking by weighing thickness is ginger slice 5g, Cortex Eucommiae 15g, the Fructus Jujubae 7g of 2mm, with the thickness of described weight proportion is that ginger slice, the Cortex Eucommiae, the Fructus Jujubae of 2mm adds 10 times of weight decoctings and boil secondary, each 1.5 hours, collecting decoction, filter, it is 1.05-1.10 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain the alcohol amount be 70% (w/w), standing over night filters, and gets liquor B, liquor B and filtrate A are merged, surveying relative density when reclaiming ethanol and being concentrated into 60 ℃ is the thick paste of 1.20-1.25, and drying under reduced pressure is ground into fine powder; Add an amount of Macrogol 4000, after heating is mixed thoroughly, splash in the another kind of not miscible liquid coolant dimethicone, drip and make ball, promptly get drop pill.This Macrogol 4000 can be used instead and be that polyoxyethylene (40) monostearate, dimethicone liquid coolant can be used instead and be in liquid paraffin or the vegetable oil any one.
Embodiment 7: prepare compound extract of the present invention and pill thereof
Weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g, Rhizoma Alismatis 9g add the ethanol extraction secondary of 10 times of weight 70% (v/v) with the Fructus Evodiae of described weight proportion, Radix Ginseng, Rhizoma Alismatis three flavors, each 1.5 hours, filter, merging filtrate, filtrate A, standby; Taking by weighing thickness is ginger slice 5g, Cortex Eucommiae 15g, the Fructus Jujubae 7g of 2mm, with the thickness of described weight proportion is that ginger slice, the Cortex Eucommiae, the Fructus Jujubae of 2mm adds 10 times of weight decoctings and boil secondary, each 1.5 hours, collecting decoction, filter, it is 1.05-1.10 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make that to contain the alcohol amount be 70% (w/w), standing over night filters, get liquor B, liquor B and filtrate A are merged, and surveying relative density when reclaiming ethanol and being concentrated into 60 ℃ is the thick paste of 1.20-1.25, drying under reduced pressure, be ground into fine powder, cross 60 purpose screen clothes; Add refined honey and medicine, make honeyed pill, promptly get pill.
Claims (6)
1, a kind of Chinese medicine preparation for the treatment of hypertension is characterized in that: according to the components by weight percent meter, and by Fructus Evodiae 3-12 part, Radix Ginseng 3-12 part, Rhizoma Alismatis 3-12 part, Cortex Eucommiae 10-20 part, Rhizoma Zingiberis Recens 2-15 part and Fructus Jujubae 5-20 part and an amount of adjuvant are prepared from.
2, the Chinese medicine preparation of treatment hypertension according to claim 1 is characterized in that: by Fructus Evodiae 9g, and Radix Ginseng 9g, Rhizoma Alismatis 9g, Cortex Eucommiae 15g, Rhizoma Zingiberis Recens 5g and Fructus Jujubae 7g add an amount of adjuvant and are prepared from.
3, the Chinese medicine preparation of treatment hypertension according to claim 1 and 2 is characterized in that described Chinese medicine preparation is: granular preparation, capsule preparations, tablet, pill or oral liquid formulations.
4, the Chinese medicine preparation of treatment hypertension according to claim 3 is characterized in that described Chinese medicine preparation is a granular preparation.
5, according to the preparation method of the Chinese medicine preparation of any described treatment hypertension among the claim 1-4, it is characterized in that: weighting raw materials material Fructus Evodiae, Radix Ginseng and Rhizoma Alismatis, the volume ratio that Fructus Evodiae, Radix Ginseng and Rhizoma Alismatis are added 8-20 times of weight is ethanol extraction 1-5 time of 50-80%, every 1-2 hour, filter, it is standby to get filtrate A; Add 8-20 times of weight water with being cut into Rhizoma Zingiberis Recens, the Cortex Eucommiae and the Fructus Jujubae that thickness is the 1-8 millimeter, extraction time 1-4 hour, carry 1-4 time altogether, collecting decoction filters, and filtrate is concentrated into the clear paste of certain relative density, put coldly, add ethanol and make medicinal liquid contain alcohol amount to be weight ratio 50-80%, to leave standstill 10-24 hour, filter, liquor B, filtrate A and liquor B are merged, recovery ethanol also is concentrated into the thick paste of certain density, drying is ground into fine powder; Add right amount of auxiliary materials, be prepared into the preparation that needs.
6, according to the preparation method of the Chinese medicine preparation of the described treatment hypertension of claim 5, it is characterized in that: the volume ratio that weighting raw materials material Fructus Evodiae 9g, Radix Ginseng 9g and Rhizoma Alismatis 9g add 8-20 times of weight is ethanol extraction 1-5 time of 50-80%, every 1-2 hour, filter, it is standby to get filtrate A; Add 8-20 times of weight water with being cut into ginger slice 5g, Cortex Eucommiae 15g and the Fructus Jujubae 7g that thickness is the 1-8 millimeter, extraction time 1-4 hour, carry 1-4 time altogether, collecting decoction filters, and filtrate is concentrated into the clear paste of certain relative density, put coldly, add ethanol and make medicinal liquid contain alcohol amount to be weight ratio 50-80%, to leave standstill 10-24 hour, filter, liquor B, filtrate A and liquor B are merged, recovery ethanol also is concentrated into the thick paste of certain density, drying is ground into fine powder; Add right amount of auxiliary materials, mixing is made granule 1000g, gets granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100868467A CN100435842C (en) | 2006-06-21 | 2006-06-21 | Chinese-medicinal preparation for treating hypertension and its making method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100868467A CN100435842C (en) | 2006-06-21 | 2006-06-21 | Chinese-medicinal preparation for treating hypertension and its making method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1895659A CN1895659A (en) | 2007-01-17 |
| CN100435842C true CN100435842C (en) | 2008-11-26 |
Family
ID=37608403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100868467A Expired - Fee Related CN100435842C (en) | 2006-06-21 | 2006-06-21 | Chinese-medicinal preparation for treating hypertension and its making method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100435842C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6243686B2 (en) * | 2013-09-30 | 2017-12-06 | 小林製薬株式会社 | An oral composition containing a processed product and a processed product of ginger, and a method for enhancing the scent of the product |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772133A (en) * | 2005-10-27 | 2006-05-17 | 杨文琳 | Hypertension treating capsule |
-
2006
- 2006-06-21 CN CNB2006100868467A patent/CN100435842C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772133A (en) * | 2005-10-27 | 2006-05-17 | 杨文琳 | Hypertension treating capsule |
Non-Patent Citations (2)
| Title |
|---|
| 吴茱萸汤证探究. 张长恩.北京中医，第2期. 1993 |
| 吴茱萸汤证探究. 张长恩.北京中医，第2期. 1993 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1895659A (en) | 2007-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103520572B (en) | A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof | |
| US20200268826A1 (en) | Application Method of Dendrobium Candidum in Preparing Medicine for Treating Hypertension | |
| CN103285309A (en) | Rhodiola rosea compound composition for treating peptic ulcer | |
| CN101543248B (en) | A cold tea especially suitable for 'three high and one acid' population and method for preparing same | |
| CN101732491A (en) | Medicament for treating hypertension, hyperlipoidemia, high blood viscosity and anti-aging | |
| CN1985921B (en) | Chinese medicine composition for treating common cold and its preparing method | |
| CN104107348A (en) | Chinese herbal medicine for blood sugar reducing, and administration method thereof | |
| CN100435842C (en) | Chinese-medicinal preparation for treating hypertension and its making method | |
| CN102293928A (en) | Chinese medicinal composition for treating hyperuricemia and urarthritis, and preparation method and application thereof | |
| CN1413697A (en) | Method for preparing Chinese medicine Liuwei Dihuang preparation | |
| CN103610795A (en) | Method for preparing eucommia ulmoides step-down oral preparation | |
| CN103520684B (en) | Traditional Chinese medicine compound for reducing blood sugar | |
| CN1192789C (en) | 'Shenhuaxiaokecha' tea and preparing method thereof | |
| US7179492B2 (en) | Traditional chinese pharmaceutical formulation for treatment of paradentosis, process for preparation and use thereof | |
| CN101549140B (en) | Traditional Chinese medicine composition for treating AIDS and preparation method thereof | |
| CN104740405B (en) | A kind of Chinese medicine preparation and preparation method for treating anaphylactoid purpura renal damage | |
| CN104771444B (en) | A kind of bathing preparation and preparation method for the treatment of of insomnia patients | |
| CN108743885A (en) | A kind of Chinese medicine and preparation method thereof for treating Diabetic Macrovascular Complications | |
| CN107913315A (en) | A kind of Chinese medicine composition for treating refractory hypertension and preparation method thereof | |
| CN103989940A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN106138494B (en) | Kidney nourishing composition and production method thereof | |
| CN113521131B (en) | Traditional Chinese medicine composition for ischemic cardiomyopathy and application thereof | |
| CN102462776A (en) | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method and application thereof | |
| CN102133274A (en) | Chinese medicinal composition | |
| CN101549063A (en) | Traditional Chinese medicine preparation for treating sleep disorder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhang Liyan Document name: Notice of application for publication of patent for invention and entry into the substantive examination procedure |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081126 Termination date: 20110621 |