CN107913315A - A kind of Chinese medicine composition for treating refractory hypertension and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating refractory hypertension and preparation method thereof Download PDF

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CN107913315A
CN107913315A CN201810018523.7A CN201810018523A CN107913315A CN 107913315 A CN107913315 A CN 107913315A CN 201810018523 A CN201810018523 A CN 201810018523A CN 107913315 A CN107913315 A CN 107913315A
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chinese medicine
medicine composition
uncaria
refractory hypertension
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CN107913315B (en
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刘明
王慧森
李更生
高雅
逯璐
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HENAN PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
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Abstract

The invention discloses a kind of Chinese medicine composition for treating refractory hypertension and preparation method thereof, the Chinese medicine composition of the treatment refractory hypertension, includes the material medicines of following parts by weight：16 33 parts of catharanthus roseus, 16 33 parts of uncaria, 15 30 parts of the root of bidentate achyranthes, 15 30 parts of umbellate pore furgus, 5 30 parts of selfheal, 5 30 parts of Ligusticum wallichii, 5 16.5 parts of Radix Paeoniae Alba.The present inventor combines pharmaceutical chemistry, analyze the dropping voltage characteristic, active component and cooperative effect of existing medicine, using the theory and viewpoint of " the plain integration of card ", it is innovative with prescriptions such as catharanthus roseus, uncaria, the root of bidentate achyranthes, umbellate pore furgus, selfheal, Ligusticum wallichii, Radix Paeoniae Albas, compatibility is reasonable, suits the interpretation of the cause, onset and process of an illness, is able to maintain that blood pressure stabilization, clinical refractory hypertension patients ' life quality is obviously improved, there is good social effect.

Description

A kind of Chinese medicine composition for treating refractory hypertension and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and its system for treating refractory hypertension Preparation Method.
Background technology
Refractory hypertension (resistant hypertension, RH) is also known as intractable hypertension, is a kind of special defects The hypertension of type, the cause of disease is complicated, and unsteered hypertension can accelerate the progress of atherosclerosis, causes the weight such as the heart, brain, kidney Target organ damage is wanted, seriously affects the quality of life of patient, serious financial burden is brought to patient and family and society.According to China《Refractory hypertension diagnoses and treatment China Consensus of experts》, RH is defined as on the basis of the mode of making the life better, applies Rationally tolerable enough >=3 kinds of antihypertensive drugs (including diuretics) treatments>Blood pressure is still below standard within 1 month, or takes >=4 kinds of drops Pressing thing blood pressure could effective effector.
Hypertension is one of most important hazards of cardiovascular and cerebrovascular disease, as blood pressure level raises, cardiovascular disease hair The corresponding increase of raw danger, the cerebral apoplexy of 50-60% and the myocardial infarction of 40-50% occur related with blood pressure rise.Hypertension It is the common Chronic Non-Communicable Diseases in China, issue in 2015《Chinese residents nourishment and chronic disease status report (2015 Year)》Point out, more than the 18 years old prevalence of hypertension rate of China in 2012 is 25.2%, according to 2010 the 6th time national population Census data measuring and calculating number of patients is about 2.7 hundred million.Crowd's Prevalence of Hypertension was from 5.11% to 2012 years of 1958 25.2%, the illness rate of China's hypertension is in obvious ascendant trend.In the process, prevention and control of the mankind for hypertension never stop Only, antihypertensive drugs also continues to introduce new, to current common antihypertensive drugs up to 104 kinds of 28 class.In current European hypertension In association/European Society of Cardiology (ESH/ESC) guide, there are five class medicines to be proposed as anti-hypertension first-line drug, including blood Guanine converting enzyme inhibitor, hypertensinⅡreceptorretarder, beta receptor blocking agent, calcium channel blocker, diuretics. But the incidence of hypertension is higher and higher, and refractory hypertension is also more and more.
Without this name of disease of high blood pressure in traditional Chinese medicine, but ancient Chinese medicine doctor according to clinical manifestation, prognosis of disease and it is common simultaneously Disease is sent out, it is belonged to the categories such as " headache ", " dizziness ", " liver-yang ", " liver wind ", and thinks that the occurrence of this disease is mainly lost with feelings will Tune, eating and drinking without temperance, internal injury are deficient, native endowment is related.The differentiation of symptoms and signs for classification of syndrome standard of high blood pressure is connect extensively by scholar in the industry at present By with being《New Chinese medicine guideline of clinical investigations》In standard, by hypertension be divided into overabundant liver-fire, phlegm wet stop up contain, Hyperactivity of yang due to yin deficiency and negative and positive two lose 4 kinds of card types.In addition, document report also claims also ecchymosis damage network, network to hinder phlegm retention；It is insufficiency of the spleen Phlegm hinders, lucid yang failing to raise type；Qi depression to blood stasis, passages through which vital energy circulates not flow-through, the deficiency of the kidney yin, liver-Yang sthenia type.For the hair of refractory hypertension Life is generally considered caused by internal organs yin and yang qi and blood disorder that its pathologic basis is that liver kidney originally loses, the high mistake degree of sun.Contemporary doctor is to difficulty The research of the property controlled hypertension, the theory more approved are imbalance of yin and yang theory, it is believed that this disease be by both liver and kidney deficiency, YIN-fluid being insufficient, Water files to nourish wood, causes the moon to hold back sun, brain key is rushed on liver-yang and is fallen ill.A part of doctor forefathers to liver kidney opinion control on the basis of with Phlegm wet is this.In addition most of doctor is then according to ancients and the difference of moderns' life habit and living environment, it is believed that heat toxin, wind Heresy is increasingly becoming the pathogenic cause of disease of equal importance with phlegm wet.
Therefore high blood pressure is a kind of under the effect of h and E factor, it is related to multi-pathogenesis, frequently-occurring disease link Complicated pathologic process, its pathogenesis is not completely clear and definite at present.And refractory hypertension is a difficulty in hypertension therapeutic Point, the diversity and uncertainty of its pathogenic factor make to there is no effective specific treatment medicine in terms of doctor trained in Western medicine, commonly use chemical drugs Thing toxic side effect is strong, controls symptom to damage liver kidney as cost more, i.e., undesirable and cannot solve root problem.
The content of the invention
In view of the deficiencies of the prior art, the object of the present invention is to provide a kind of Chinese medicine composition for treating refractory hypertension And preparation method thereof, which can effectively reduce refractory hypertension patients' blood.
To achieve these goals, the technical solution adopted in the present invention is：
A kind of Chinese medicine composition for treating refractory hypertension, includes the material medicine of following parts by weight：Catharanthus roseus 16-33 Part, 16-33 parts of uncaria, 15-30 parts of the root of bidentate achyranthes, 15-30 parts of umbellate pore furgus, 5-30 parts of selfheal, 5-30 parts of Ligusticum wallichii, 5-16.5 parts of Radix Paeoniae Alba.
A kind of preparation method for the Chinese medicine composition for treating refractory hypertension, the Chinese medicine composition can be prepared into Tablet, powder, capsule, decoction, pill, granule, oral liquid.
Pharmacology analysis：
Catharanthus roseus is the herb of Apocynaceae periwinkle plant catharanthus roseus Catharanthus roseus (L.) G Don. Bitter, it is cold in nature.Return liver and kidney channel.Whole year can adopt.Clean, segment, dry spare or using fresh herb.Its cool in nature, mildly bitter flavor, enter kidney two warp, With certain toxicity and stronger pharmacological activity.Except for antitumaous effects such as acute lymphatic leukemia, lymphosarcomas Outside, there is tranquilizing and allaying excitement, soothing the liver antihypertensive effect, can be used for controlling hypertension.
Uncaria is madder wort uncaria Uncaria rhynch0phylla (Miq.) Jacks., largeleaf gambirplant branchlet Uncaria Macrophylla Wall., uncaria hirsuta Uncaria hirsuta Havil., Uncaria sinensis Uncaria sinensis (Oliv.) Havil. or stockless fruit uncaria Uncaria sessilifructus Roxb. drying buckle stem branch.It is sweet in flavor, cold nature.Return Liver, pericardium channel.Autumn, the harvesting of two season of winter, defoliation, segment, is dried.Function and cured mainly in current edition Chinese Pharmacopoeia as The flat liver of heat-clearing, Dispelling wind and relieving convulsion.For dizziness of having a headache, dysphoric cold, twitch, pre-eclampsia；Hypertension.Its main active is indoles Alkaloid component, the Alkaloid have greater advantage in terms for the treatment of angiocardiopathy especially hypertension.It studies main Concentrate on rhynchophyllin and isorhynchophylline.Zoopery shows, rhynchophyllin and isorhynchophylline can block the calcium of intracellular storage The characteristics of plasma diffusing W,Mo, wherein rhynchophyllin is that renal blood flow does not have significant changes while reducing blood pressure.
The root of bidentate achyranthes is the dry root of amaranthaceous plant root of bidentate achyranthes Achyranthes bidentata BL..It is bitter, sweet, sour, it is mild-natured. Return liver and kidney channel.Henan mainly is originated in, is traditional conventional Chinese medicine in China.Winter cauline leaf is excavated when withered, removes fibrous root and mud Sand, is bundled into wisp, shines to shriveling, and top is trimmed, and dries.Its is sweet in flavor, sour, bitter, mild-natured, enters liver and kidney channel.With by the stasis of blood The effect of promoting menstruation, ensurings proper downward flow of the blood, filling liver kidney, strengthening the bones and muscles, it is dizzy for powerless, soreness of waist and knee joint for the treatment of muscles and bones, Jing Bi Disorder lumps in the abdomen, liver-yang It is dizzy.The root of bidentate achyranthes contains a variety of chemical compositions such as carbohydrate, saponins, plant ketosteroid, flavonoids.Pharmacological research shows that the root of bidentate achyranthes has Blood pressure lowering, anti-inflammatory, analgesia, the pharmacological action for adjusting immune, antitumor, anti-aging etc..It is commonly used to treat on modern clinic Angiocardiopathy, has document to show that radix achyranthis bidentatae decocting liquid and liquid extract have certain adjusting blood pressure and diuresis.It can make rabbit Blood pressure declines immediately, and blood pressure has rise phenomenon again after decline, but the blood pressure level after rise is consistently lower than the blood before being administered Voltage levels.
Umbellate pore furgus is the dry sclerotia of On Polyporaceae umbellate pore furgus Polyporus umbellatus (Pers.) Fries.Taste It is sweet, light, it is mild-natured.Return kidney, bladder warp.Spring, the excavation of two season of autumn, remove silt, dry.Clearing damp and promoting diuresis is the primary efficacy of umbellate pore furgus, There is diuresis, anticancer and antibacterial.Research shows, the component in umbellate pore furgus mainly have polysaccharide, steroid, nonsteroidal, Amino acids, vitamins and small-scale inorganic element etc., wherein ergot steroid -4,6,8 (14), 22- tetraene -3- ketone are the profits of umbellate pore furgus Component is urinated, it makes Na+/K+ ionic equilibriums change to produce diuresis by antagonism aldosterone.
Selfheal is the drying fruit ear of labiate selfheal Prunella vulgaris L..It is bitter, pungent, it is cold in nature. Return liver, gallbladder channel.Summer fruit ear harvests when being in brownish red, removes impurity, dries.Selfheal has blood pressure lowering, hypoglycemic, antitumor Etc. multiple pharmacological effect, wherein selfheal stem, leaf, fringe and herb has antihypertensive effect.Water-leach liquor, the alcohol-water of selfheal Leachate and 30% alcohol leaching liquid, the effect of reducing blood pressure to anesthetized animal.Decoction (100mg/Kg) is injected in anesthetized dog, Significantly lasting antihypertensive effect can be produced, but is also easy to produce and is rapidly resistant to；To renal hypertension dog, after continuously taking medicine 2 weeks, blood pressure has Moderate reduction, recovers to originally horizontal again after drug withdrawal.
Ligusticum wallichii is the dry rhizome of samphire Ligusticum wallichii Ligusticum chuanxiong Hort..Acrid flavour, it is warm-natured. Return liver, gallbladder channel.Summer is significantly prominent when the section disk on stem, and is excavated during purplish, removes silt, dry after solarization, then removes palpus Root.Ligusticum wallichii is the common drug for invigorating blood circulation and eliminating stasis of the traditional Chinese medical science, containing volatile oil (based on phthalide and its dimer constituents), alkaloid, The component such as organic acid and polysaccharide.Ligusticum wallichii and its chemical fraction, monomer component are to cardio-cerebrovascular, nervous system, respiratory system Have etc. multiple systems and improve function of vascular endothelium and coronary blood flow, reduce resistance of blood flow and blood pressure, antioxidant radical, Many pharmacological actions such as anti-inflammatory, anticancer, platelet aggregation-against, antithrombus formation, protection nerve.Wherein forulic acid is Ligusticum wallichii The index component of medicinal material, and active ingredient.With platelet aggregation-against, suppress platelet 5-HT release, suppress blood The generation of platelet thromboxane a2 (txa2), strengthens prostaglandin activity, and analgesia, alleviates a variety of effects such as vasopasm, is production For treating the base stock of the disease medicine such as cardiovascular and cerebrovascular disease and Neuroleptic Leukocytopenia.
Radix Paeoniae Alba bitter, acid, cold nature.Return liver, the spleen channel.Summer, the excavation of two season of autumn, clean, remove end to end and radicula, put boiling water In boil after remove crust or peeling after boil again, dry.Radix Paeoniae Alba has a variety of physiology and pharmacological activity, and undesirable reagentia is small. Isoprel myocardial oxygen consumption caused by mouse can significantly wherein be resisted to the effect of cardiovascular system, Radix Paeoniae Alba water extract Increase, the acute myocardial ischemia caused by antagonism pituitrin, increases cardiac muscle nutritional blood flow, extends mouse in normal pressure and low The time-to-live of anoxic is pressed in, its main component Paeoniflorin can be in endothelium-dependent relaxation vascular smooth muscle, and mechanism of action may Promote NO synthesis releases related with it, released with calcium-activated potassium channel and suppression vascular smooth muscle cells extrinsic AGB stars and interior calcium Put unrelated.In addition, Paeoniflorin can promote people's marrow fibroblastoid stromal cell line system (HFCL), proliferation index and energy generation are improved Thank, suppress its apoptosis, play blood tonification effect indirectly.
Treatment with TCM hypertension has its unique theory and practice, and for a long time, diagnosis and treatment hypertension is tcm clinical practice The method of diagnosing a disease of tradition and classics.The present inventor has found that patient is most normal in the dialectical practice for a long time of high blood pressure hospital of Henan Province Witness type is that phlegm wet stops up Sheng, overabundant liver-fire syndrome, and clinic opinion is controlled using catharanthus roseus, uncaria as monarch, wherein catharanthus roseus slight bitter cool in nature, medicine source Extensively, whole year can adopt, and enter conscience two and pass through, and have the effect of soothing the liver decompression, tranquilizing and allaying excitement.Modern pharmacological research, its contained biology Alkali has quick and more lasting antihypertensive effect；The sweet cold Return liver of uncaria and pericardium, suppressing the hyperactive liver to relieve the wind syndrome, heat-clearing stop convulsion, and disappear dizzy calmness, its hook The expansible peripheral vessels of rattan alkali, reducing heart rate, calmness decompression.The two is combined into, and work(is specially depressured, the dizziness of the main clear key that disappears.The root of bidentate achyranthes is Henan name Sheng specialty, four-Huai medicine, bitter sour in taste acting on the liver kidney, mild-natured main drop,《Herbal justice》Cloud：" profit drop-down is dredged, leads all qi and blood heap soil or fertilizer over and around the rootss Stagnant disease "；Umbellate pore furgus enters spleen kidney bladder warp, and diuresis excreting dampness, swollen arteries and veins of harnessing the river is swollen, and solely this is most prompt.Selfheal bitter cold enters liver and gall, the above three Medicine phases 5 are minister, that is, wait upon left and right, and association " monarch " fights, and divide the volt heresy of disappear " phlegm ", " stasis of blood ", " fire ", respectively take charge of the chief.It is rhizome of chuanxiong, white Chinese herbaceous peony thoughts of returning home liver, walks brain key, and suppressing liver-YANG, acupuncture-stimulating blood stasis dispersing, holds back cloudy soft pulse, makes altogether for assistant with disappear " arteries and veins is swollen ".Therefore seven medicine of a side, shape dissipate And god does not dissipate, " wind ", " phlegm ", " stasis of blood ", " fire " are attacked directly, cut down " arteries and veins is swollen ", made a concerted effort and be, quickly, effectively, enduringly control refractory Property hypertension, achieves satisfied clinical efficacy.
Embodiment
The embodiment of the present invention is described in further detail with reference to embodiments.
Embodiment 1
A kind of Chinese medicine composition tablet for treating refractory hypertension, includes the material medicine of following weight：Catharanthus roseus 556g, uncaria 556g, the root of bidentate achyranthes 556, umbellate pore furgus 556g, selfheal 278g, Ligusticum wallichii 278g, Radix Paeoniae Alba 278g.
Preparation method (1000), comprises the following steps：Each material medicine is weighed by weight, is mixed, and adds material medicine The water of 14 times of amounts of gross weight decocts 2 times, each 1.5h, filtering, merges decocting liquid and is condensed into relative density 1.10- at 50 DEG C 1.12 thick paste, adds ethanol, stirring while adding, reaches 60% (v/v) to concentration of alcohol, stands 48h, and filtering, takes filtrate, returns Ethanol is received, and is condensed into the thick paste that relative density at 60 DEG C is 1.18-1.20, auxiliary material dextrin 50g, Icing Sugar 150g is added and mixes and make For bottom material, spraying granulation, whole grain adds the magnesium stearate of total weight of material 2%, tabletting, to obtain the final product.
Embodiment 2
A kind of Chinese traditional medicine composition composition powders for treating refractory hypertension, include the material medicine of following weight：Catharanthus roseus 160g, uncaria 160g, root of bidentate achyranthes 150g, umbellate pore furgus 150g, selfheal 50g, Ligusticum wallichii 50g, Radix Paeoniae Alba 50g.
Preparation method, comprises the following steps：Each material medicine is mixed, adds in high-speed multifunctional pulverizer and crushes, mistake 200 mesh sieves, obtain Chinese medicine impalpable powder, dispense to 1000 bags, sterilizing, to obtain the final product.
Embodiment 3
A kind of Chinese medicinal composition capsules agent for treating refractory hypertension, includes the material medicine of following weight：Catharanthus roseus 660 parts, uncaria 660g, root of bidentate achyranthes 600g, umbellate pore furgus 600g, selfheal 400g, Ligusticum wallichii 400g, Radix Paeoniae Alba 330g.
Preparation method (1000), comprises the following steps：Catharanthus roseus, uncaria, umbellate pore furgus, Ligusticum wallichii is weighed by weight to crush, Respectively plus 8 times of 70% ethanol of bulking value fraction soak 4h, and then 80 DEG C of refluxing extractions 3 times, each 1h, it is simultaneously dense to merge decocting liquid It is reduced to relative density 1.10-1.12 at 50 DEG C, the catharanthus roseus respectively obtained, uncaria, umbellate pore furgus, the alcohol extract of Ligusticum wallichii；By weight The root of bidentate achyranthes, selfheal, Radix Paeoniae Alba are weighed, is mixed, the water for adding 3 kinds of material medicine gross weights, 14 times of amounts decocts 2 times, each 1.5h, mistake Filter, merges decocting liquid and is condensed into the thick paste of relative density 1.10-1.12 at 50 DEG C, add ethanol, add while stirring, to second Determining alcohol reaches 60% (v/v), stands 48h, and filtering, takes filtrate, merge with the alcohol extract of catharanthus roseus, uncaria, umbellate pore furgus, Ligusticum wallichii, Ethanol is recycled, and it is 1.18-1.20 to be concentrated into relative density at 60 DEG C, adds auxiliary material dextrin 50g, pregelatinized starch 100g conducts Bottom material, spraying granulation, whole grain, adds the silica of total weight of material 2%, encapsulated, to obtain the final product.
Embodiment 4
A kind of Chinese medicine composition decoction for treating refractory hypertension, includes the material medicine of following parts by weight：Catharanthus roseus 22 parts, 22 parts of uncaria, 20 parts of the root of bidentate achyranthes, 20 parts of umbellate pore furgus, 15 parts of selfheal, 10 parts of Ligusticum wallichii, 10 parts of Radix Paeoniae Alba.
Preparation method, comprises the following steps：Each material medicine is weighed by weight, is mixed, and adds material medicine gross weight 6 The water immersion 30min of amount again, then decoct 2 times, each 60min, merge decocting liquid, and be concentrated into and suitably drink dosage twice, Dispense to obtain the final product.
When taking decoction, per 60-70g Chinese medicine compositions to be one, take day it is one, once in the morning and once at night.
Related experimental data is as follows：
1st, the standard of case is selected
1.1 general information
Using 120 RH patients of randomized controlled method choice, with 1:2 ratios are grouped, i.e., conventional Chinese medicine for lowering high blood pressure plain film For control group (40), Chinese medicine composition of the invention is observation group (80), carries out clinical research, wherein male 63, female Property 57, age 34-69 Sui, average age (58 ± 3.0) year, the course of disease -5 years 10 months, average course of disease (45 ± 2.3) moon.
1.2 diagnostic criteria
Diagnostic criteria of the modern medicine to high blood pressure：In the case of unused antihypertensive, non-measurement on the 3rd on the same day is received Contracting pressure >=140mmHg and (or) diastolic pressure >=90mmHg, diagnosable is hypertension.According to China《Refractory hypertension diagnosis is controlled Treat Chinese Consensus of experts》RH is defined as on the basis of the mode of making the life better, and applies rationally tolerable enough >=3 kinds of decompressions Medicine (including diuretics) is treated>Blood pressure is still below standard within 1 month, or takes >=4 kinds of effective effectors of antihypertensive drugs blood pressures ability.
TCM syndrome diagnostic criteria (《New Chinese medicine guideline of clinical investigations》)：
1) overabundant liver-fire.Primary symptom：There are dizziness, headache, being irritable and getting angry easily.Minor symptom：Flushing, hot eyes, dry, bitter taste, constipation, urinate Red, red tongue with yellowish fur, wiry and frequent pulse.
2) hyperactivity of yang due to yin deficiency.Primary symptom：Dizziness, headache, the soreness of waist, waist are soft, dysphoria in chestpalms-soles.Minor symptom：It is palpitaition, insomnia, tinnitus, strong Forget, the red few tongue of tongue, small and wiry pulse and count.
3) phlegm wet, which is stopped up, contains.Primary symptom：Dizziness, headache, head are such as wrapped up in, are uncomfortable in chest, vomitting sputum.Minor symptom：Palpitaition, insomnia, mouth is light, eats Less, the fat tongue of tongue is greasy, slippery.
4) negative and positive two are lost.Primary symptom：Dizziness, headache, the soreness of waist, waist are soft, aversion to cold and cold limbs.Minor symptom：Tinnitus, palpitaition, shortness of breath, enuresis nocturna Frequently, pale tongue with white fur, deeptensepulse are thin and delicate.
1.3 inclusive criterias and exclusion standard
Inclusive criteria：
1) version in 2010 is met《Chinese high blood pressure guideline of prevention and treatment》Hypertension standard；
2) meet《Refractory hypertension diagnoses and treatment China Consensus of experts》RH is defined；
3) blood pressure is in more than 140/90mmHg；
4) age is between 18-70 Sui；
5) non-medication, or take hypertension drug but be discontinued 2 weeks after；
6) hyperpiesia, 3 pressure measurement, blood pressure do not reach diagnostic criteria on the same day in 1 week；
7) hepatic and renal function checks without exception, to observation medicine and control drug not allergy；
8) informed consent form is obtained.
Exclusion standard：
1) version in 2010 is not met《Chinese high blood pressure guideline of prevention and treatment》Standard；
2) secondary hypertension；
3) age was under-18s or more than 70 years old；
4) gestation or women breast-feeding their children；
5) serious primary disease, the mental patient such as hemopoietic system are associated with.
2nd, therapeutic scheme
Foundation《New Chinese medicine guideline of clinical investigations》Hypertension diagnosis parting standard, to 120 RH patient's traditional Chinese medical science diseases Shape is summarized, and is classified as：Hyperactivity of liver-fire 45；Phlegm wet stops up 39, Sheng type；Hyperactivity of yang due to yin deficiency, negative and positive two such as lose at the syndrome totally 36 Example, every kind of disease is with 1:2 ratios are randomly divided into control group and observation group, and observation group takes orally the tablet for giving the embodiment of the present invention 1 Treated, control group gives antihypertensive tablet, and oral dose is that 6 tablets once, 3 times a day.
3rd, criterion of therapeutical effect and result
3.1 curative effect determinate standard
1) it is effective：1. more than diastole drops 10mmHg (1.3kPa), and reach normal range (NR)；2. though diastolic pressure does not drop to Normally but decline 20mmHg (2.7kPa) or more, must possess wherein 1.
2) effectively：1. diastole drops have reached normal range (NR) not as good as 10mmHg (1.3kPa)；2. diastolic pressure is relatively treated Preceding decline 10-19mmHg (1.3-2.5kPa), but not up to normal range (NR)；3. systolic pressure declines 30mmHg (4kPa) before relatively treating More than, need to possess wherein 1.
3) it is invalid：Not up to effective standard person.
Total effective rate=effective percentage+obvious effective rate
3.2 treatment results
Effective 3 of hyperactivity of liver-fire observation group, effective 26, total effective rate 96.67%；Effective 2 of control group, effectively 11, total effective rate 86.67%.
Effective 2 of phlegm wet Yong Sheng types observation group, effective 23, total effective rate 96.15%；Effective 2 of control group, effectively 9, total effective rate 84.62%.
Effective 2 of hyperactivity of yang due to yin deficiency, negative and positive Liang Kuideng syndromes observation group, effective 19, total effective rate 87.50%；Control Effective 1 of group, effective 9, total effective rate 83.33%.
Treatment results find that the Chinese medicine composition of the present invention has good therapeutic effect to refractory hypertension, especially Notable for the therapeutic effect of hyperactivity of liver-fire and phlegm wet heap soil or fertilizer over and around the roots Sheng type case, total effective rate is substantially better than control group.
3.3 adverse reaction
120 patients treated through 2 weeks, and no 1 the adverse reactions such as diarrhea, dizziness, fash occurs, and hepatic and renal function checks equal nothing It is abnormal.
4th, conclusion
Antihypertensive tablet be by selfheal, pueraria lobata, mother-of-pearl, chrysanthemum, lophatherum gracile, rutin, mistletoe, radix scutellariae, menthol, Dragon and the glutinous rehmannia Chinese medicinal tablet that prepared by totally ten a herb prescriptions, belong to conventional Chinese medicine depressor, above clinical study results table Bright, preparation prepared by inventive formulation has when treating overabundant liver-fire and phlegm wet stops up and contains sick for the refractory hypertension of different TCM syndrome types There is the effect of more preferable, better than antihypertensive tablet.
It is mainly liver that theory of traditional Chinese medical science, which discloses high blood pressure, the heart, kidney, imbalance of yin and yang, wind, fire, phlegm and caused by interacting, because This is in addition to calming the liver, vital energy regualting and blood circulation-promoting, and Qingre Quyu is the effective way for treating hypertension.It has been recognised by the inventors that to intractable height The Chinese medicine study of blood pressure should break through traditional frame, analyze and its origin cause of formation and lapse to, and hold the overall situation of its syndrome, and with " wind ", " phlegm (turbid) ", " fire ", " stasis of blood ", " arteries and veins is swollen " for crucial, core Syndrome in TCM usually express it is more appropriate cut with it is feasible.Cause The invention people combines pharmaceutical chemistry, analyzes the dropping voltage characteristic, active component and cooperative effect of existing medicine, using " card element system The theory and viewpoint of conjunction ", it is innovative to be closed with the prescriptions such as catharanthus roseus, uncaria, the root of bidentate achyranthes, umbellate pore furgus, selfheal, Ligusticum wallichii, Radix Paeoniae Alba, compatibility Reason, suits the interpretation of the cause, onset and process of an illness, is able to maintain that blood pressure stabilization, hence it is evident that improves clinical refractory hypertension patients ' life quality, has well Social effect.

Claims (10)

1. a kind of Chinese medicine composition for treating refractory hypertension, it is characterised in that include the material medicine of following parts by weight：It is long 16-33 parts of spring flower, 16-33 parts of uncaria, 15-30 parts of the root of bidentate achyranthes, 15-30 parts of umbellate pore furgus, 5-30 parts of selfheal, 5-30 parts of Ligusticum wallichii, Radix Paeoniae Alba 5-16.5 part.
2. the Chinese medicine composition for the treatment of refractory hypertension according to claim 1, it is characterised in that including following weight The material medicine of part：20 parts of catharanthus roseus, 20 parts of uncaria, 20 parts of the root of bidentate achyranthes, 20 parts of umbellate pore furgus, 10 parts of selfheal, 10 parts of Ligusticum wallichii, Radix Paeoniae Alba 10 Part.
3. the Chinese medicine composition for the treatment of refractory hypertension according to claim 1, it is characterised in that including following weight Material medicine：16 parts of catharanthus roseus, 16 parts of uncaria, 15 parts of the root of bidentate achyranthes, 15 parts of umbellate pore furgus, 5 parts of selfheal, 5 parts of Ligusticum wallichii, 5 parts of Radix Paeoniae Alba.
4. the Chinese medicine composition for the treatment of refractory hypertension according to claim 1, it is characterised in that including following weight The material medicine of part：33 parts of catharanthus roseus, 33 parts of uncaria, 30 parts of the root of bidentate achyranthes, 30 parts of umbellate pore furgus, 20 parts of selfheal, 20 parts of Ligusticum wallichii, Radix Paeoniae Alba 16.5 parts.
5. the Chinese medicine composition for the treatment of refractory hypertension according to claim 1, it is characterised in that including following weight The material medicine of part：22 parts of catharanthus roseus, 22 parts of uncaria, 20 parts of the root of bidentate achyranthes, 20 parts of umbellate pore furgus, 15 parts of selfheal, 10 parts of Ligusticum wallichii, Radix Paeoniae Alba 10 Part.
6. a kind of preparation method for the Chinese medicine composition that refractory hypertension is treated such as claim 1-5 any one of them, its It is characterized in that, the Chinese medicine composition can prepare piece agent, powder, capsule, decoction, pill, granule, oral liquid.
7. the preparation method of the Chinese medicine composition for the treatment of refractory hypertension according to claim 6, it is characterised in that institute The preparation method of Chinese medicine composition tablet is stated, is comprised the following steps：Each material medicine is weighed by weight, is mixed, and adds raw material The water of 14 times of amounts of medicine gross weight decocts 2 times, each 1.5h, filtering, merges decocting liquid and is condensed into relative density at 50 DEG C The thick paste of 1.10-1.12, adds ethanol, stirring while adding, reaches 60% to concentration of alcohol, stands 48h, and filtering, takes filtrate, returns Ethanol is received, and is condensed into the thick paste that relative density at 60 DEG C is 1.18-1.20, adds auxiliary materials and mixing as bottom material, spraying granulation, Whole grain, adds the magnesium stearate of total weight of material 2%, tabletting, to obtain the final product.
8. the preparation method of the Chinese medicine composition for the treatment of refractory hypertension according to claim 6, it is characterised in that institute The preparation method of Chinese traditional medicine composition composition powders is stated, is comprised the following steps：Each material medicine is mixed, adds high-speed multifunctional pulverizer Middle crushing, crosses 200 mesh sieves, obtains Chinese medicine impalpable powder, sterilizes, to obtain the final product.
9. the preparation method of the Chinese medicine composition for the treatment of refractory hypertension according to claim 6, it is characterised in that institute The preparation method of Chinese medicinal composition capsules agent is stated, is comprised the following steps：Catharanthus roseus, uncaria, umbellate pore furgus, Rhizoma Chuanxiong power are weighed by weight Broken, respectively plus 8 times of 70% ethanol of bulking value fraction soak 4h, and then 80 DEG C of refluxing extractions 3 times, each 1h, merge decocting liquid And relative density 1.10-1.12 at 50 DEG C is concentrated into, the catharanthus roseus respectively obtained, uncaria, umbellate pore furgus, the alcohol extract of Ligusticum wallichii；By weight Amount part weighs the root of bidentate achyranthes, selfheal, Radix Paeoniae Alba, mixes, the water decoction of 3 kinds of addition, 14 times of material medicine gross weights amount 2 times, every time 1.5h, filtering, merges decocting liquid and is condensed into the thick paste of relative density 1.10-1.12 at 50 DEG C, add ethanol, add while stirring Enter, reach 60% to concentration of alcohol, stand 48h, filtering, takes filtrate, is closed with the alcohol extract of catharanthus roseus, uncaria, umbellate pore furgus, Ligusticum wallichii And ethanol is recycled, and it be 1.18-1.20 to be concentrated into relative density at 60 DEG C, and addition auxiliary material is as bottom material, spraying granulation, whole grain, The silica of total weight of material 2% is added, it is encapsulated, to obtain the final product.
10. the preparation method of the Chinese medicine composition for the treatment of refractory hypertension according to claim 6, it is characterised in that The preparation method of the Chinese medicine composition decoction, comprises the following steps：Each material medicine is weighed by weight, is mixed, and is added former Expect the water immersion 30min of 6 times of amounts of medicine gross weight, then decoct 2 times, each 60min, merge decocting liquid twice, to obtain the final product.
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CN112022977A (en) * 2020-10-20 2020-12-04 河南中医药大学第一附属医院 Traditional Chinese medicine composition for treating hypertension and traditional Chinese medicine preparation and application thereof
CN112022977B (en) * 2020-10-20 2022-07-12 河南中医药大学第一附属医院 Traditional Chinese medicine composition for treating hypertension and traditional Chinese medicine preparation and application thereof

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