CN101732491B - Medicament for treating hypertension, hyperlipoidemia, high blood viscosity and anti-aging - Google Patents
Medicament for treating hypertension, hyperlipoidemia, high blood viscosity and anti-aging Download PDFInfo
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Abstract
The invention discloses a medicament for treating hypertension, hyperlipoidemia, high blood viscosity and anti-aging, which is prepared by taking barbary wolfberry fruit, cassia seed, emblic leafflower fruit, mulberry, ginkgo, Chinese date, hawthorn fruit, kudzuvine root, peach seed, safflower and hippophae rhamnoides as raw materials, and decocting and extracting the raw materials in certain proportion. The medicament can be prepared into common oral formations, has the functions of tonifying the kidney and nourishing the liver, promoting blood circulation and removing blood stasis, nourishing qi to generate fluid and the like, has the obvious effect of treating the hypertension and the hyperlipoidemia, and reducing blood viscosity, and also has obvious effect on antifatigue and anti-aging, quick response, and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of antidotal medicine, particularly relate to a kind of with botanical herbs and all be that the Chinese medicine of medicine-food two-purpose is Comprehensive Treatment hypertension, hyperlipidemia, the high blood viscosity (hereinafter to be referred as " three-hypers ") and antidotal medicine that raw material is made.
Background technology
" three-hypers " is one of the most common disease of middle-aged and elderly people, and the complication of Yin Faing is a lot of therefrom, is to have a strong impact on patient's life-prolonging factor.
In the last few years, owing to people's rhythm of life is accelerated, many reasons such as dietary structure is unreasonable, quantity of motion minimizing, it is increasing that " three-hypers " patient accounts for the ratio of total population, become the persistent ailment that threatens health of people, also is the one of the main reasons of patient's aging.Used medicine usually based on Western medicine, belong to symptomatic treatment, and effect does not make us very satisfied more at present.
In the medicine of treatment " three-hypers ", although herbal species such as some defying age, resisting fatigue, blood circulation promoting and blood stasis dispelling are arranged, the Chinese patent medicine at the Comprehensive Treatment of " three-hypers " is not found in literature search.In many blood pressure lowering, blood fat reducing, fall in the Western medicine of blood viscosity, certain toxic and side effects is all arranged, the medicine animal experiment that has also has carcinogenesis.
Inventing a kind of medicine that curative effect does not reliably have toxic and side effects, Comprehensive Treatment " three-hypers " and the life lengthening effect is arranged that has, is inventor's purpose.Make a general survey of Chinese medicine and western medicine market, such medicine still belongs to blank.
Summary of the invention
The purpose of this invention is to provide a kind of treatment " three-hypers " and antidotal medicine.With traditional determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is criterion, the kidney invigorating is held concurrently with liver nourishing, invigorate blood circulation assistant to nourish blood, blood stasis dispelling is aided with QI invigorating, monarch is clearly demarcated, it is apt to fill a prescription, dialectically combine with differential diagnosis of diseases, Chinese and Western medicine is closed ginseng, used medicine all proves the produce effects and the reliability of its blood pressure lowering, blood fat reducing, reducing blood viscosity through the relevant pharmacological evaluation of modern medicine, prove its resisting fatigue, antidotal produce effects and reliability, and every herbal medicine pointing out all and do not have toxic and side effects, is the good medicine of a kind of Comprehensive Treatment hypertension, hyperlipidemia, high blood viscosity.
The present invention realizes with following technical scheme.A kind of treatment " three-hypers " and antidotal medicine is characterized in that it is to make with conventional preparation method with the raw material of following weight parts: Fructus Lycii 10-30 part, Semen Cassiae 10-30 part, Fructus Phyllanthi 10-24 part, Fructus Mori 10-30 part, the sub-10-24 part of Semen Ginkgo, Fructus Jujubae 10-30 part, Fructus Crataegi 6-30 part, Radix Puerariae 6-30 part, Semen Persicae 6-24 part, Flos Carthami 6-24 part, Fructus Hippophae 6-30 part.
Above-mentioned raw materials medicine and consumption prescription are the inventors through just drawing with how tame medical institutions associating clinical trials for many years, all have significant curative effect in above-mentioned amount ranges.
Medicament selection Fructus Lycii of the present invention, Semen Cassiae, Fructus Phyllanthi, Fructus Mori, Semen Ginkgo, Fructus Jujubae, Fructus Crataegi, Radix Puerariae, Semen Persicae, Flos Carthami, Fructus Hippophae carry out compatibility, each efficacy of drugs produces synergism, thus reach bring high blood pressure down, blood fat reducing, blood viscosity lowering and antidotal curative effect.Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight in the side have the promotion immunologic function, and modern pharmacological research confirms, its defying age, and resisting fatigue, blood fat reducing, anti-fatty liver, blood pressure lowering, effect such as blood sugar lowering is significantly; The Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation has effects such as blood pressure lowering, blood fat reducing; Fructus Phyllanthi is a kind of nourishing Tibetan medicine, and effect such as its defying age, antioxidation, inhibition arteriosclerosis obviously; The Fructus Mori yin nourishing of enriching blood, the liver nourishing kidney tonifying makes eye bright and calms the nerves, and effect such as its antioxidation, defying age, blood fat reducing, antimutagenic is outstanding; The sub-astringing lung QI for relieving asthma of Semen Ginkgo, leukorrhagia stopping is turbid, urine reducing, function well such as its blood vessel dilating, protection brain, removing free radical; The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind has effects such as antioxidation, enhance immunity, antitumor, mutation, arteriosclerosis; Hawthorn digesting is good for the stomach, and its heart tonifying of circulation of qi promoting dissipating blood stasis is dirty, blood pressure lowering, blood fat reducing, preventing tumor, aid digestionly waits effect significantly, and antioxidation is arranged, senile-resistant efficacy; The Radix Puerariae yang invigorating promotes the production of body fluid, and effects such as good defying age, blood pressure lowering, blood fat reducing, blood sugar lowering, antitumor, Fructus Alpiniae Oxyphyllae are arranged; The Semen Persicae blood circulation promoting and blood stasis dispelling, its antitumor, antioxidation, defying age, protect the liver, effect such as immunomodulating obviously; The Flos Carthami blood circulation promoting and blood stasis dispelling, resolving stagnation for tranquilization can increase coronary flow, improves myocardial ischemia, blood fat reducing, blood pressure lowering, antitumor, resisting fatigue, defying age; Fructus Hippophaeization stagnate to be removed long-pending, and promoting blood circulation to remove blood stasis has antitumor, protection cardiovascular, defying age, resisting fatigue, antioxidation, blood fat reducing, protects the liver, effects such as anti-platelet aggregation, antiallergic.This side's combination, nourishing YIN and invigorating YANG, QI and blood regulating, the stagnant blood stasis dispelling of row, all medicine cooperations bring out the best in each other, and meet the basic principle of tcm treatment according to syndrome differentiation fully, also meet differential diagnosis of diseases and the dialectical basic characteristic that combines.
Moreover, the pharmacological action of said medicine all has relevant pharmacological research and animal experiment conclusion.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to make dosage form for oral administration.Medicine of the present invention can be ground into crude drug in powder and be mixed into powder, electuary, granule, oral liquid.Can get active ingredient with being condensed into decocting liquid behind each crude drug decocting, refabrication becomes various oral agents, but these do not limit protection scope of the present invention.
The present invention preferably adopts following capsule formulation and tablet.
The preparation method of described medicine, carry out as follows:
(1) take by weighing raw material in proportion, standby;
(2) Fructus Lycii, Semen Cassiae, Fructus Phyllanthi, Fructus Mori, Semen Ginkgo, Fructus Jujubae, Fructus Crataegi, Radix Puerariae, Semen Persicae, Flos Carthami and the Fructus Hippophae 11 flavor medicines with described weight ratio decoct with water 5 times, merge decocting liquid then 5 times;
(3) step (2) gained decocting liquid is condensed into extractum;
(4) extractum is dried dry extract;
(5) pulverize the dry extract powdering;
(6) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(7) incapsulate.
Each amount of water of described step (2) was not advisable to have powder, decocted 30 minutes at every turn.
Described step (5) gained medicated powder and tablet adjuvant commonly used is mixed, and tabletting becomes tablet.
Medicine of the present invention shows that through clinical use result following advantage is arranged:
1, to select the natural edible-plant medicine for use be raw material in the present invention, and each component meets Medicine Act regulation and tcm prescription principle, gives prominence to the basic characteristic that Chinese medical discrimination combines with the doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;
2, medicine of the present invention need not decoct, good mouthfeel, and taking convenience, all nontoxic before and after each herbal medicine prescription, normal dose is taken and is not found any side effect;
3, medicine of the present invention not only has excellent curative to hypertension, hyperlipidemia, high blood viscosity, and the good preventing health-care effect is also arranged, and the scope of application is extensive;
4, all selected but safety is higher in the kind of Ministry of Public Health regulation medicine-food two-purpose for medicine of the present invention, and treatment person in middle and old age " three-hypers " can take for a long time;
Symptoms such as 5, medicine of the present invention has the good property taken into account, and constipation, insomnia, the blood glucose that middle-aged and elderly people is occurred easily is higher have certain therapeutical effect of taking into account;
6, medicine treating both the principal and secondary aspects of a disease of the present invention takes effect rapidly.
The specific embodiment
Add up the effect that further specifies medicine of the present invention below in conjunction with embodiment and clinical practice.
Embodiment 1: the capsule preparation
Fructus Lycii 24kg, Semen Cassiae 18kg, Fructus Phyllanthi 20kg, Fructus Mori 20kg, the sub-18kg of Semen Ginkgo, Fructus Jujubae 15kg, Fructus Crataegi 18kg, Radix Puerariae 18kg, Semen Persicae 12kg, Flos Carthami 12kg, Fructus Hippophae 18kg are added the common decoction of water 5 times, add water was not advisable to have powder at every turn, the each decoction 30 minutes merges 5 times decocting liquid; Decocting liquid by conventional alcohol extraction, is condensed into extractum; Extractum is put into drying baker oven dry back pulverizing be fine powder, and carry out conventional high-temperature sterilization; Fine powder is incapsulated every medicated powder 0.45g.
Embodiment 2: preparation tablets
With Fructus Lycii 12kg, Semen Cassiae 10kg, Fructus Phyllanthi 12kg, Fructus Mori 12kg, the sub-10kg of Semen Ginkgo, Fructus Jujubae 10kg, Fructus Crataegi 15kg, Radix Puerariae 12kg, Semen Persicae 10kg, Flos Carthami 10kg, Fructus Hippophae 15kg, make medicated powder with embodiment 1 described method, be aided with tablet adjuvant commonly used again and make tablet or electuary, every medicated powder 0.5g of tablet, every bag of 2g of electuary.
Clinical drug of the present invention is observed
One, ordinary circumstance and test method
For confirming the clinical efficacy of medicine of the present invention, in in March, 2009-2009 year December, select patient age 45-55 year 122 examples, wherein male 67 examples, woman's 55 examples, wherein between 95-115mmHg, the serum analysis observation item is T-CHOL, triglyceride to the blood pressure systolic pressure at 135-165mmHg, diastolic pressure, and three of blood viscositys all exceed normal reference value 20% above person.122 examples are all taken embodiment 1 medicament capsule, every day 3 times, each 5, take and check These parameters in 3 months once more.Take treatment front and back Self-control method.
Two, clinical observation criterion of therapeutical effect is: measure blood pressures three times and reduce to normal range after treating, T-CHOL, triglyceride, blood viscosity reduce to all that the person is produce effects in normal range; Measuring blood pressure for three times has and reaches normal range twice, in T-CHOL, triglyceride, the blood viscosity 1-2 item reach in the normal value or three reductions all 10% above person for effective; Blood pressure and T-CHOL, triglyceride, blood viscosity all do not reach above-mentioned standard or the person of increasing the weight of is invalid.
Three, observe the curative effect shows, treatment back produce effects 52 examples, and effective 63 examples, invalid 7 examples, total effective rate is 94.26%.
Claims (5)
1. medicine for the treatment of hypertension, hyperlipidemia, high blood viscosity is characterized in that it is to be made by following raw medicaments in portion by weight:
The sub-10-24 part of Fructus Lycii 10-30 part Semen Cassiae 10-30 part Fructus Phyllanthi 10-24 part Fructus Mori 10-30 part Semen Ginkgo
Fructus Jujubae 10-30 part Fructus Crataegi 6-30 part Radix Puerariae 6-30 part Semen Persicae 6-24 part Flos Carthami 6-24 part Fructus Hippophae 6-30 part.
2. the preparation method of medicine according to claim 1 is characterized in that may further comprise the steps:
A) take by weighing each crude drug, standby;
B) Fructus Lycii, Semen Cassiae, Fructus Phyllanthi, Fructus Mori, Semen Ginkgo, Fructus Jujubae, Fructus Crataegi, Radix Puerariae, Semen Persicae, Flos Carthami, the Fructus Hippophae 11 flavor medicine water purification with described weight proportion decoct with water 5 times after washing, add water was not advisable to have powder at every turn, merge 5 times decoction liquor, filter to get filtrate 1;
C) filtrate 1 is condensed into extractum, dry extract is made in oven dry in drying baker;
D) dry extract is broken into powdery.
3. the preparation method of medicine according to claim 1 is characterized in that may further comprise the steps:
A) take by weighing each crude drug, standby;
B) decoct with water 5 times after Fructus Lycii, Semen Cassiae, Fructus Phyllanthi, Fructus Mori, Semen Ginkgo, Fructus Jujubae, Fructus Crataegi, Radix Puerariae, Semen Persicae, Flos Carthami and the Fructus Hippophae 11 flavor medicine water purification flushings with described weight proportion, add water was not advisable to have powder at every turn, merge 5 times decoction liquor, filter to get filtrate 1;
C) filtrate 1 is suitably concentrated, handle the oral liquid of directly making effective ingredient through corrosion-proof and sterilization.
4. preparation method according to claim 2, it is characterized in that with the powder of step d) gained 110 ℃ incapsulate after the sterilization cooling in 10 minutes down capsule.
5. preparation method according to claim 2 is characterized in that the powder of step d) gained is mixed with tablet adjuvant commonly used, and tabletting becomes tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101144261A CN101732491B (en) | 2010-02-26 | 2010-02-26 | Medicament for treating hypertension, hyperlipoidemia, high blood viscosity and anti-aging |
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| CN2010101144261A CN101732491B (en) | 2010-02-26 | 2010-02-26 | Medicament for treating hypertension, hyperlipoidemia, high blood viscosity and anti-aging |
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| CN101732491B true CN101732491B (en) | 2011-06-22 |
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| CN102335335A (en) * | 2010-07-27 | 2012-02-01 | 张立中 | Traditional Chinese medicine preparation with effects of health care and physical fatigue alleviation |
| CN102145059B (en) * | 2011-04-07 | 2012-06-27 | 于国录 | Chinese patent medicament for treating intractable hypertension |
| CN102302689A (en) * | 2011-08-25 | 2012-01-04 | 南京苏美瑞医药科技有限公司 | Chinese medicinal composition capable of reducing blood sugar, and preparation method and application of Chinese medicinal composition |
| CN106974031A (en) * | 2016-01-19 | 2017-07-25 | 深圳市古方中药饮片有限公司 | A kind of three green tea and preparation method thereof |
| CN106962937A (en) * | 2017-04-11 | 2017-07-21 | 姜红成 | Prepare fermentation composition and preparation method with prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing effect plant enzyme |
| CN107625886A (en) * | 2017-09-11 | 2018-01-26 | 黑龙江引创基因生物技术有限公司 | A kind of emblic compound surrogated tea and preparation method thereof |
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| CN1286111A (en) * | 1999-08-27 | 2001-03-07 | 侯德善 | Chinese-medicinal prescription for lowering blood pressure |
| CN1211111C (en) * | 2002-11-27 | 2005-07-20 | 天大药业(深圳)有限公司 | Antilipemic Chinese medicine |
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Effective date of registration: 20190729 Address after: 511458 X1301-E2535, No. 106 Fengze East Road, Nansha District, Guangzhou City, Guangdong Province Patentee after: Yuanshengtai (Guangzhou) Biotechnology Co.,Ltd. Address before: Room 101, Unit 3, Building 4, Hongrun Garden, Xuzhou City, Jiangsu Province, 221008 Patentee before: Wang Zhongmin |
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Effective date of registration: 20240304 Address after: Room 401, Building 1, No. 10 Huancui South Road, Liwan District, Guangzhou City, Guangdong Province, 510000 Patentee after: Fengmao Holdings (Guangdong) Co.,Ltd. Guo jiahuodiqu after: Zhong Guo Patentee after: Wang Zhongmin Address before: 511458, No.106 Fengze East Road, Nansha District, Guangzhou City, Guangdong Province (self designated Building 1) X1301-E2535 Patentee before: Yuanshengtai (Guangzhou) Biotechnology Co.,Ltd. Guo jiahuodiqu before: Zhong Guo |