CN106176907A - Raise for reducing the blood fat caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof - Google Patents
Raise for reducing the blood fat caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof Download PDFInfo
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- 239000008280 blood Substances 0.000 title claims abstract description 32
- 201000005577 familial hyperlipidemia Diseases 0.000 title claims abstract description 26
- 235000009200 high fat diet Nutrition 0.000 title claims abstract description 26
- 230000002265 prevention Effects 0.000 title claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 20
- 241000208340 Araliaceae Species 0.000 claims abstract description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 15
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- 235000008434 ginseng Nutrition 0.000 claims abstract description 15
- 241001251068 Formica fusca Species 0.000 claims abstract description 14
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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Abstract
The invention discloses a kind of for reducing the blood fat rising caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof.Chinese medicine composition of the present invention is made up of Semen Cassiae, Formica fusca powder and Radix Ginseng.By zoopery, the present invention proves that this Chinese medicine composition can effectively alleviate the blood fat rising that high fat diet is caused, and reduce its obese degree, prevention and treatment hyperlipidemia, the clinical treatment for hyperlipidemia and obesity that proposes of the present invention provides a kind for the treatment of means based on Chinese medicine composition.
Description
Technical field
The present invention relates to the blood fat caused by a kind of effective alleviation high fat diet raise, reduce obese degree, prevent and control
Treat Chinese medicine composition of hyperlipemia and application thereof, the invention belongs to Chinese medicine research technical field.
Background technology
Along with the improving constantly of people's living standard, dietary structure and life style generation great change, the blood fat of crowd
Level is the most in rising trend.Hyperlipemia is a kind of disease common and multiple in metabolic disease, itself and diabetes, heart and brain
Angiopathy is closely related.Massive epidemiology all has proven to hyperlipemia and the sickness rate of cardiovascular and cerebrovascular disease and dead in bright
Aobvious positive correlation.Therefore, adjust lipid metabolism generation and the development of preventing and treating cardiovascular and cerebrovascular disease are extremely important.Beautiful
The coronary heart disease study on prevention that state's cardiovascular and cerebrovascular disease institute has been carried out 7 years confirms: the application of fat-reducing medicament can reduce heart and brain blood
Pipe mortality 24%, reduces non-lethality heart attack rate 19%.Blood fat reducing can delay or alleviate atherosclerosis
The development of pathological changes, and promote that it disappears.
At present, although multiple Western medicine has Regulation serum lipids, but once drug withdrawal, curative effect is prone to disappear, prolonged application
There is untoward reaction more.Therefore, by the research to Chinese medicine, find safely, effectively, the tune fat Chinese medicine of persistent, especially
Scientific exploration is reasonably treated the clinical treatment of hyperlipemia and is just seemed extremely important.
Chinese medicine has the history of thousand of years, and extensively, gentle lasting, toxicity is little in its effect, it is possible to by regulation the moon
Sun, strengthens immunity, comprehensive onset.Chinese medicine is because complicated component, it is possible to reduces blood glucose simultaneously, reduce blood fat, improve microcirculation, has
Effect complication prevention.Particularly Chinese medicine composition can pass through multipath, treat hyperlipemia by all kinds of means, just with hyperlipemia
Multi-pathogenesis, multifactorial theory are consistent.Therefore, Chinese medicine particularly Chinese medicine composition, in hyperlipemia therapeutic field, just makes up
The deficiency of Western medicine, has huge advantages for development.
Semen Cassiae just has records such as " clothes can be beneficial with nothing left for a long time, makes light of one's life by commiting suicide " in Shennong's Herbal, is listed in 120 kinds " for monarch
Main life of supporting is with Ying Tian " one of medicine-feeding.Its nature and flavor are sweet, bitter, salty, be slightly cold, and are apt to, into liver, kidney, large intestine channel, have liver heat removing and eyesight improving, profit
Effect of intestinal relieving constipation, is one of the material of 69 kinds of integration of edible and medicinal herbs announced of health ministry, and the Multiple components contained is to hyperlipemia
Disease has obvious curative effect.Formica fusca powder is to be that raw material dries a kind of health food of pulverizing, containing many with Polyhachis vicina Roger
Plant aminoacid, dimension biology, trace element, cursive script formaldehyde and superoxide dismutase, there is the work of strengthening the body resistance, nourishing and fit keeping function
With, the metabolism of body can be promoted, have body-building and anti-aging effects.Radix Ginseng is one of China's special product valuable ingredient of Chinese medicine, and ancient times cure
First appeared in Shennong's Herbal in pharmacy books, it is classified as top grade.According to documents and materials introduction, before more than 2,000 years, people just by
Gradually find that Radix Ginseng has strongly invigorating primordial QI, peaceful body Fructus Alpiniae Oxyphyllae, supplementing QI for promoting the production of body fluid, qi-restoratives righting, effect of life lengthening.
The Chinese medicine composition of the present invention is to cure mainly nature and flavor, by artificial combination shape according to theory of Chinese medical science and single medicinal material function
The medicable comparatively safe natural composition of tool become.Traditional Chinese medical science medicining mode based on suspensoid embodies this Chinese medicine composition
The safety of thing and effectiveness, and there is effective substance natural, rational, including optimum chemical composition kind and quantity
Portfolio ratio relation, realize optimal therapeutic effect by the compatibility principle of prescription " monarch, minister, help, make ".
At present, prevent and treat hyperlipemia blood fat to raise, reduce obese degree, improve the life matter of hyperlipidemia patient
Amount has important practical significance.Research shows the Chinese medicine composition of the present invention, it is possible to prevent and treat high fat diet to be caused
Blood fat raise, be effectively improved the obese degree of hyperlipidemia patient.The proposition of the present invention is that future clinical treats hyperlipemia
Blood fat raises, and reduces obese degree and provides novel effective treatment means, also complies with current development trend simultaneously.
Summary of the invention
It is an object of the invention to provide the blood fat caused by a kind of effective reduction high fat diet to raise, reduce fat journey
Degree, prevents and treats the Chinese medicine composition of hyperlipemia.
In order to achieve the above object, present invention employs techniques below means:
The present invention is screened by the multiple means such as Chinese medicinal formulae, tcm theory and is designed and effectively reduces high fat diet institute
The blood fat caused raises, and reduces the Chinese medicine composition of obese degree and prevention and treatment hyperlipemia and preparation method thereof.
The Chinese medicine composition that the present invention obtains is made up of Semen Cassiae, Formica fusca powder and Radix Ginseng.The present invention is big by giving SD bull
Hyperlipidemia model is set up in Mus high fat diet, detects Blood Lipid after surrounding.After model success, continuous gastric infusion surrounding.Experiment knot
Fruit shows, the Chinese medicine composition of the present invention can effectively be alleviated the blood fat caused by high fat diet and raise, and reduces its fat journey
Degree, prevents and treats hyperlipemia.
Therefore, on the basis of the studies above, the present invention proposes the blood fat caused by a kind of effective reduction high fat diet
Raising, reduce obese degree and prevention and the Chinese medicine composition for the treatment of hyperlipemia, described Chinese medicine compound is Semen Cassiae, Formica fusca
Powder and Radix Ginseng composition.
In the present invention, it is preferred to, the weight ratio of described Semen Cassiae, Formica fusca powder and Radix Ginseng is 4-6:3-5:0.1-1,
More preferably 5.5:4:0.5.
Further, the invention allows for described Chinese medicine composition in preparation for reducing caused by high fat diet
Blood fat raises, and reduces obese degree, the purposes prevented and treat in the medicine of hyperlipemia.
Suitable the raising for effectively alleviation blood fat caused by high fat diet of a kind of clinic, effectively reduces its fat journey
Degree, prevents and treats the compound Chinese medicinal preparation of hyperlipemia, and it is by adding preparation in above-described Chinese medicine composition
Adjuvant needed for molding, makes according to pharmaceutical preparation conventional method, does not repeats them here.
Described preparation can be powder, capsule, pill, granule, tablet or suspension.
The present invention proposes the blood fat caused by a kind of effective reduction high fat diet and raises, and reduces obese degree and prevention
With the effective ways for the treatment of hyperlipemia, the complication being caused prevention and alleviation hyperlipidemia is significant.
Accompanying drawing explanation
After Fig. 1 is high fat diet 4 weeks, the blood lipid level change of SD rat before being administered；
Fig. 2 is that after being administered 2 weeks, each group rat fat changes cartogram；
Fig. 3 is group SD rat fat change cartogram each after being administered 4 weeks；
Fig. 4 compares cartogram for group rat body weight rate of increase each after being administered 4 weeks；
Fig. 5 compares cartogram for group rat Lee index each after being administered 4 weeks.
Detailed description of the invention
Further describe the present invention, advantages of the present invention and feature below in conjunction with specific embodiments and the drawings will be with
Describe and apparent.But embodiment is only exemplary, the scope of the present invention is not constituted any restriction.Art technology
Personnel it should be understood that can be to the details of technical solution of the present invention and form under without departing from the spirit and scope of the present invention
Modify or replace, but these amendments and replacement each fall within protection scope of the present invention.
Embodiment 1 is for reducing the blood fat rising caused by high fat diet, fat and prevention and treatment hyperlipemia
The preparation of Chinese medicine composition
After Semen Cassiae and Radix Ginseng grinds, with Formica fusca powder according to the weight ratio of Semen Cassiae, Formica fusca powder and Radix Ginseng it is
The ratio mix homogeneously of 5.5:4:0.5, to obtain final product.
Embodiment 2 is for reducing the blood fat rising caused by high fat diet, fat and prevention and treatment hyperlipemia
The preparation of Chinese medicine composition
After Semen Cassiae and Radix Ginseng grinds, it is 4 with Formica fusca powder according to the weight ratio of Semen Cassiae, Formica fusca powder and Radix Ginseng:
The ratio mix homogeneously of 3.5:0.1, to obtain final product.
Embodiment 3 is for reducing the blood fat rising caused by high fat diet, fat and prevention and treatment hyperlipemia
The preparation of Chinese medicine composition
After Semen Cassiae and Radix Ginseng grinds, it is 6 with Formica fusca powder according to the weight ratio of Semen Cassiae, Formica fusca powder and Radix Ginseng:
The ratio mix homogeneously of 5:1, to obtain final product.
The experimental technique of unreceipted actual conditions in following Examples, generally according to proposed by normal condition or manufacturer
Condition operates.
Experimental example 1: the Chinese medicine composition of the present invention impact on High fat diet rats blood fat
1, the foundation of hyperlipidemia model
Prepare hyperlipidemia model rat process as follows: buy the SD male rat 30 of SPF rank, in Harbin Medical University
Animal experimental center is raised.Laboratory animal first carries out after normal feedstuff adaptability raises one week, giving high fat diet, examining after surrounding
Survey blood lipid level changes.
After Fig. 1 is high fat diet 4 weeks, the blood lipid level change of SD rat before being administered；It can be seen that screening SD is big
The success of Mus hyperlipidemia model model.
2, dosage
Chinese medicine composition: the powder prepared according to embodiment 1 preparation method, takes 2g powder and is scattered in 24ml water system
Standby one-tenth suspension carries out gavage to rat, by 10 times of calculating dosages of tested material adult's dosage, rat dosage 0.42g
(solute)/kg (body weight), 1 times/day, successive administration 4 weeks.
3, result
Fig. 2 is to be administered each group rat fat change cartogram after 2 weeks, it can be seen that with high fat group ratio, by reagent
Thing group serum TC has reduction trend, n=6～7；Fig. 3 is group SD rat fat change cartogram each after being administered 4 weeks；Can from figure
To find out, with high fat group ratio, test medicine group serum TC substantially reduces, n=6～7,*P < 0.05vs height fat group.
Experimental example 2: the Chinese medicine composition of the present invention impact on High fat diet rats obese degree
1, the foundation of hyperlipidemia model
Prepare hyperlipidemia model rat process as follows: buy the SD male rat 30 of SPF rank, in Harbin Medical University
Animal experimental center is raised.Laboratory animal first carries out after normal feedstuff adaptability raises one week, giving high fat diet, examining after surrounding
Survey blood lipid level changes.
2, dosage period
Chinese medicine composition: the powder prepared according to embodiment 1 preparation method, takes 2g powder and is scattered in 24ml water system
Standby one-tenth suspension carries out gavage to rat, by 10 times of calculating dosages of tested material adult's dosage, rat dosage 0.42g
(solute)/kg (body weight), 1 times/day, successive administration 4 weeks.
3, result
Fig. 4 compares cartogram for group rat body weight rate of increase each after being administered 4 weeks；It can be seen that with high fat group ratio,
Test medicine group body weight increases and slows down, n=6～7.Fig. 5 compares cartogram for group rat Lee index each after being administered 4 weeks；From figure
In it can be seen that with high fat group ratio, test medicine group obese degree substantially reduces, n=6～7.
Claims (6)
1., for reducing the blood fat rising caused by high fat diet, reduce obese degree, prevent and treat the Chinese medicine of hyperlipemia
Compositions, it is characterised in that described Chinese medicine composition is made up of Semen Cassiae, Formica fusca powder and Radix Ginseng.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that the weight of described Semen Cassiae, Formica fusca powder and Radix Ginseng
Ratio is 4-6:3-5:0.1-1.
3. Chinese medicine composition as claimed in claim 2, it is characterised in that the weight of described Semen Cassiae, Formica fusca powder and Radix Ginseng
Ratio is 5.5:4:0.5.
4. the Chinese medicine composition described in any one of claim 1-3 is used for reducing the blood fat liter caused by high fat diet in preparation
Height, reduces obese degree, the purposes prevented and treat in the medicine of hyperlipemia.
5. a clinic suitable for raising for reducing the blood fat caused by high fat diet, reduce obese degree, prevention and
Treatment hyperlipemia compound Chinese medicinal preparation, it is characterised in that in the Chinese medicine composition described in any one of claim 1-3
Add the adjuvant needed for preparations shaping, make the most suitable various preparations according to pharmaceutical preparation conventional method.
6. compound Chinese medicinal preparation as claimed in claim 5, it is characterised in that described preparation be powder, capsule, pill,
Granule, tablet or suspension.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610794772.6A CN106176907A (en) | 2016-08-31 | 2016-08-31 | Raise for reducing the blood fat caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610794772.6A CN106176907A (en) | 2016-08-31 | 2016-08-31 | Raise for reducing the blood fat caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof |
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|---|---|
| CN106176907A true CN106176907A (en) | 2016-12-07 |
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| CN201610794772.6A Pending CN106176907A (en) | 2016-08-31 | 2016-08-31 | Raise for reducing the blood fat caused by high fat diet, Chinese medicine composition of fat and prevention and treatment hyperlipemia and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449783A (en) * | 2003-04-03 | 2003-10-22 | 杨宝峰 | Traditional Chinese medicine formule for treating hyperlipemia |
| CN1682837A (en) * | 2005-03-11 | 2005-10-19 | 哈尔滨医科大学 | Medicine for regulating blood fat and its preparing method |
| CN101450129A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition with blood-pressure reduction and blood-fat reduction function |
| CN101549046A (en) * | 2009-05-19 | 2009-10-07 | 范警民 | Health preserving product of north Chinese Caterpillar Fungus and glossy ganoderma |
-
2016
- 2016-08-31 CN CN201610794772.6A patent/CN106176907A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449783A (en) * | 2003-04-03 | 2003-10-22 | 杨宝峰 | Traditional Chinese medicine formule for treating hyperlipemia |
| CN1682837A (en) * | 2005-03-11 | 2005-10-19 | 哈尔滨医科大学 | Medicine for regulating blood fat and its preparing method |
| CN101450129A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition with blood-pressure reduction and blood-fat reduction function |
| CN101549046A (en) * | 2009-05-19 | 2009-10-07 | 范警民 | Health preserving product of north Chinese Caterpillar Fungus and glossy ganoderma |
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Application publication date: 20161207 |
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