CN110251591A - A kind of pharmaceutical composition and its preparation method and application that aided blood pressure-lowering is hypoglycemic - Google Patents
A kind of pharmaceutical composition and its preparation method and application that aided blood pressure-lowering is hypoglycemic Download PDFInfo
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Abstract
The present invention provides a kind of pharmaceutical compositions that aided blood pressure-lowering is hypoglycemic, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: 3~5 parts of lotus leaf, 3~5 parts of mulberry leaf, 1~3 part of cassia seed, 1~3 part of tealeaves, 1~3 part of hawthorn, 1~3 part of sophora flower, 1~3 part of chrysanthemum.The present invention also provides the preparation method of the tea bag and purposes.By pulverizing, each raw material the effective elements of the medicine can sufficiently be discharged, be made the best use of everything pharmaceutical composition of the present invention, save herb resource；And there is good aided blood pressure-lowering hypoglycemic effect, the raising significant in efficacy compared with lotus leaf or mulberry leaf are used alone, illustrate that a few taste bulk pharmaceutical chemicals in pharmaceutical composition of the present invention have played synergistic function, taking pharmaceutical composition of the present invention for a long time can be effectively controlled blood glucose and blood pressure, keep it in normal range (NR).Meanwhile pharmaceutical composition of the present invention uses the medicinal material of integration of drinking and medicinal herbs for bulk pharmaceutical chemicals, pharmacological property is mild, takes for a long time and has no toxic side effect, has a good application prospect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of pharmaceutical composition and its system that aided blood pressure-lowering is hypoglycemic
Preparation Method and purposes.
Background technique
Hypertension is a kind of clinical syndrome characterized by arterial systolic blood pressure or diastolic pressure increase, it be often accompanied by heart,
The systemic diseases such as blood vessel, brain and kidney and other organs, structure.And hyperglycemia refers to that content sugared in blood samples of patients remains super for a long time
Normal level out.Hypertension and hyperglycemia often exist simultaneously, promote mutually, damage to body.Due to operating pressure
Increase, diet is unreasonable, work and rest is irregular, does not get enough athletic exercise etc., and reasons, hypertension and hyperglycemia patient groups constantly expand, and
Increasingly rejuvenation.Country defends disease control office, planning commission and Chinese hypertension alliance statistical report: high in 18 years old Chinese or more adult
Blood pressure patient is more than 300,000,000 people, there is 6~700,000,000 Chinese adult " blood pressure is undesirable ".
Mainly there is two class of non-drug therapy and drug therapy for the treatment of hypertension and hyperglycemia.The former is primarily referred to as leading to
It crosses and changes lifestyles, to eliminate the hazard factor to cause elevation of the blood pressure with blood glucose rise, such as: controlling into salt amount, drinking amount, control
Weight processed suitably takes exercises, makes daily schedule rule etc..The latter is, to control blood pressure and blood glucose, to make its dimension by taking drugs
It holds in normal range (NR).
Currently, clinical treatment hypertension and hyperglycemia be based on Western medicine, but suffer from the drawback that long-term use antidiabetic drug
Liver and kidney can be made dysfunction (such as biguanides) occur, be easy that body is made to generate antibody, lose drug effect etc.；Long-term clothes
Blood vessel can be made brittle with depressor, accelerate blood vessel to become silted up and hinder, cerebral hemorrhage is promoted to break out；And take Western medicine for a long time, it needs by liver
Kidney metabolism, also can grievous injury liver kidney, so that liver kidney is generated various lesions.
Summary of the invention
Of the existing technology in order to solve the problems, such as, the present invention provides a kind of pharmaceutical compositions that aided blood pressure-lowering is hypoglycemic
Object and its preparation method and application.
The present invention provides a kind of pharmaceutical compositions that aided blood pressure-lowering is hypoglycemic, it is by the raw material of following weight proportion
The preparation that medicine is prepared: 3~5 parts of lotus leaf, 3~5 parts of mulberry leaf, 1~3 part of cassia seed, 1~3 part of tealeaves, 1~3 part of hawthorn, Chinese scholartree
Spend 1~3 part, 1~3 part of chrysanthemum.
Further, pharmaceutical composition above-mentioned is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: lotus leaf 4
Part, 4 parts of mulberry leaf, 2 parts of cassia seed, 2 parts of tealeaves, 2 parts of hawthorn, 2 parts of sophora flower, 2 parts of chrysanthemum.
Further, the tealeaves is green tea.
Further, pharmaceutical composition above-mentioned is by the medicinal powder of each weight proportion bulk pharmaceutical chemicals, the water of bulk pharmaceutical chemicals or organic
Solvent extractable matter is active constituent, in addition the preparation that pharmaceutically acceptable auxiliary material is prepared.
Further, the preparation is oral preparation.
Further, the oral preparation is decoction, oral solution, granule, capsule, tablet, powder, pill, medicinal tea.
Further, the medicinal tea is tea bag.
The present invention also provides a kind of methods for preparing pharmaceutical composition above-mentioned, it includes the following steps:
(1) each bulk pharmaceutical chemicals are weighed by weight ratio；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, in addition pharmaceutically acceptable
Auxiliary material is prepared into preparation.
Further, the method includes the following steps:
(1) each bulk pharmaceutical chemicals are weighed by weight ratio；
(2) bulk pharmaceutical chemicals are beaten into powder, packs, is prepared into tea bag.
The present invention also provides pharmaceutical compositions above-mentioned to prepare the purposes in the hypoglycemic drug of aided blood pressure-lowering.
In the present invention, green tea takes the young leaves or bud of tea tree, not fermented, prepares through techniques such as water-removing, shaping, drying
It forms.
The present invention combines traditional Chinese medicine theory and modern medical theory, and selection integration of drinking and medicinal herbs medicinal material is raw material
The pharmaceutical composition of medicine, preparation is made of lotus leaf, mulberry leaf, cassia seed, tealeaves, hawthorn, sophora flower and chrysanthemum.
Lotus leaf bitter, it is mild-natured, return liver, spleen, stomach meridian, there is the effect of clearing away summer-heat and eliminating dampness, sending up the lucid yang, cooling blood and hemostasis；Mulberry leaf
Have effects that dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clear liver and improve vision, the mulberry leaf polysaccharide wherein contained in mulberry leaf has significant drop blood
Sugar and the inhibition raised effect of blood lipid；Cassia seed bitter, sweet, salty, cold nature enters liver, kidney, large intestine channel, has relax bowel and defecation, drop
The effect of rouge improving eyesight, for treating constipation and hyperlipidemia, hypertension.The effect of three medicines are combined into monarch drug in a prescription, enhance hypoglycemic.Minister with
Tealeaves, hawthorn, sophora flower, chrysanthemum, can cooling blood, stopping bleeding, clearing liver and purging fire and promoting digestion and removing indigestion, activating blood circulation and dissipating blood stasis, and can be clearing heat and detoxicating.
Make a general survey of full side, clearing away summer-heat and eliminating dampness, dispelling wind and heat from the body, clearing away the lungheat and moisturizing clears liver and improve vision, promoting digestion and removing indigestion, relax bowel and defecation, to reach lipid-loweringing drop
Effect of sugar.
Pharmaceutical composition process of the present invention pulverizes, and each raw material the effective elements of the medicine can sufficiently discharge, and object uses up it
With saving herb resource；And there is good aided blood pressure-lowering hypoglycemic effect, it is treated compared with lotus leaf or mulberry leaf are used alone
Effect significantly improves, and illustrates that a few taste bulk pharmaceutical chemicals in pharmaceutical composition of the present invention have played synergistic function, takes this hair for a long time
Bright pharmaceutical composition can be effectively controlled blood glucose and blood pressure, keep it in normal range (NR).Meanwhile pharmaceutical composition of the present invention uses
The medicinal material of integration of drinking and medicinal herbs is bulk pharmaceutical chemicals, and pharmacological property is mild, takes for a long time and has no toxic side effect, has a good application prospect.
Obviously, above content according to the present invention, according to the ordinary technical knowledge and customary means of relevant art,
Under the premise of not departing from above-mentioned basic fundamental thought of the invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
Raw material, equipment used in the specific embodiment of the invention are known product, are obtained by purchase commercial product.
The preparation of embodiment 1, pharmaceutical composition of the present invention
1, bulk pharmaceutical chemicals: lotus leaf 4g, mulberry leaf 4g, cassia seed 2g, tealeaves 2g, hawthorn 2g, sophora flower 2g, chrysanthemum 2g.
2, preparation method: weighing each bulk pharmaceutical chemicals by above-mentioned weight, and powder is beaten after bulk pharmaceutical chemicals are mixed, and packs to get tea bag.
The preparation of embodiment 2, pharmaceutical composition of the present invention
1, bulk pharmaceutical chemicals: lotus leaf 3g, mulberry leaf 3g, cassia seed 3g, tealeaves 3g, hawthorn 1g, sophora flower 1g, chrysanthemum 1g.
2, preparation method: weighing each bulk pharmaceutical chemicals by above-mentioned weight, and powder is beaten after bulk pharmaceutical chemicals are mixed, and packs to get tea bag.
The preparation of embodiment 3, pharmaceutical composition of the present invention
1, bulk pharmaceutical chemicals: lotus leaf 5g, mulberry leaf 5g, cassia seed 1g, tealeaves 1g, hawthorn 3g, sophora flower 3g, chrysanthemum 3g.
2, preparation method: weighing each bulk pharmaceutical chemicals by above-mentioned weight, and powder is beaten after bulk pharmaceutical chemicals are mixed, and packs to get tea bag.
The preparation of embodiment 4, pharmaceutical composition of the present invention
1, bulk pharmaceutical chemicals: lotus leaf 4g, mulberry leaf 5g, cassia seed 3g, tealeaves 2g, hawthorn 2g, sophora flower 2g, chrysanthemum 2g.
2, preparation method: weighing each bulk pharmaceutical chemicals by above-mentioned weight, and powder is beaten after bulk pharmaceutical chemicals are mixed, and packs to get tea bag.
Beneficial effects of the present invention are proved below by way of specific clinical test.
The clinical efficacy of test example 1, pharmaceutical composition of the present invention
1, clinical case
Observation case totally 60, male 30, female 30, the age is 48.5 ± 6.5 years old average.
1.1 diagnostic criteria
1. hypertension diagnosis is using the standard of Chinese Treatment Guidelines for Hypertension suggestion in 2005:
| Classification | Systolic pressure (mmHg) | Diastolic pressure (mmHg) |
| Normal arterial pressure | <120 | <80 |
| Normal high level | 120~139 | 80~89 |
| Hypertension | ≥140 | ≥90 |
2. hyperglycemia includes prediabetes and diabetes.Prediabetes refer to that blood glucose has built up, but without reaching
To diabetes diagnostic criterion, blood glucose is between a kind of situation normally between diabetes.The fasting blood-glucose of normal person should be lower than
6.1mmol/L, postprandial two hours blood glucose should be lower than 7.8mmol/L；Diabetes fasting blood-glucose is equal to or higher than 7.0mmol/L, or
Postprandial two hours blood glucose is equal to or higher than 11.1mmol/L；Prediabetes fasting blood-glucose 6.1mmol/L~7.0mmol/L it
Between and/or postprandial two hours blood glucose between 7.8mmol/L~11.1mmol/L.
1.2 are included in standard
1. the age 18 years old to 70 years old；2. meeting hypertension index and hyperglycemia (prediabetes and diabetes) index.
1.3 exclusion criteria
1. age < 18 years old or > 70 years old；2. not meeting diagnostic criteria and being included in standard person；3. with cardiovascular and cerebrovascular, liver,
The serious diseases such as kidney or hemopoietic system or psychiatric patient；4. meeting the standard of being included in, to the compliance of doctor's advice difference or cannot
Follow-up person on schedule, so that can not judge that curative effect or data do not carry out therapeutic evaluation person completely without method.
2, treatment method
Experimental group: using the method for embodiment 1, bulk pharmaceutical chemicals lotus leaf 4g, mulberry leaf 4g, cassia seed 2g, tealeaves 2g, hawthorn are weighed
2g, sophora flower 2g, chrysanthemum 2g beat powder after mixing each bulk pharmaceutical chemicals, pack to get pharmaceutical composition tea bag of the present invention.
Control group 1: weighing lotus leaf 18g, according to the method for experimental group, lotus leaf is beaten powder, is packed to get lotus leaf bag tea.
Control group 2: weighing mulberry leaf 18g, according to the method for experimental group, mulberry leaf is beaten powder, are packed to get folium mori tea bag.
60 cases are randomly divided into 3 groups (experimental group, control group 1 and control groups 2), every group of 20 people.60 cases receive
Tea bag is taken while routine medication, three times per day, is taken altogether 3 months.The present invention is taken in daily three postprandial 30min
Pharmaceutical composition tea bag (experimental group), lotus leaf bag tea (control group 1) or folium mori tea bag (control group 2), tea bag works as water
It drinks, adopts and brew tea bag in a like fashion and drunk.
Measurement: early on every Mondays to measure patients' blood's value before the meal, measure patient's fasting blood sugar and postprandial 2h in the afternoon on every Fridays
Blood glucose value.
3, curative effect determinate standard
It is clearly better: systolic pressure < 120, diastolic pressure < 80；Fasting blood-glucose < 5.0,2h-plasma glucose < 6.5.
It improves: systolic pressure 120~139, diastolic pressure 80~89；Fasting blood-glucose < 6.1,2h-plasma glucose < 7.8.
It is invalid: systolic pressure >=140, diastolic pressure >=90；Fasting blood-glucose >=6.1,2h-plasma glucose >=7.8.
Total effective rate=the rate of being clearly better+improvement rate.
4, treatment results
The effect of each group tea bag aided blood pressure-lowering is as shown in table 1, and the effect of auxiliary hyperglycemic is as shown in table 2.
The experimental result of 1 each group tea bag aided blood pressure-lowering of table
The experimental result of 2 each group tea bag auxiliary hyperglycemic of table
The experimental results showed that the total effective rate of experimental group (pharmaceutical composition tea bag of the present invention) blood pressure lowering is 100%, it is right
Total effective rate according to 1 (lotus leaf bag tea) blood pressure lowering of group is 75%；Experimental group (pharmaceutical composition tea bag of the present invention) is hypoglycemic
Total effective rate be 100%, the hypoglycemic total effective rate of control group 2 (folium mori tea bag) be 70%.Meanwhile by Tables 1 and 2
Known to experimental result: same way same dose takes each group tea bag, takes pharmaceutical composition tea bag of the present invention (experiment
Group) after, patient's average systolic and AvDP are lower than the patient for taking lotus leaf bag tea (control group 1), and in normal
It is worth in range；Patient is averaged fasting blood-glucose and average postprandial blood sugar lower than the patient for taking folium mori tea bag (control group 2), and locates
In in range of normal value.Illustrate that pharmaceutical composition aided blood pressure-lowering of the present invention is hypoglycemic to work well, and significant in efficacy is better than
Lotus leaf or mulberry leaf are used alone.
5, typical case
5.1 classical cases 1
Hypertension, hyperglycemia patient: male, 65 years old, when not taking tea bag of the present invention, 7.2 mM/ls of preprandial glucose；Clothes
After tea bag of the present invention 5 days, 5.9 mM/ls of preprandial glucose, continuously take, blood glucose maintains normal range (NR).Bag is not taken
When making tea, systolic pressure 155mmHg, diastolic pressure 102mmHg；After taking tea bag 5 days, systolic pressure and diastolic pressure are all restored to normally
Value.
To sum up, pharmaceutical composition of the present invention is by pulverizing, and each raw material the effective elements of the medicine can sufficiently discharge, object
Its use to the greatest extent, saves herb resource；And there is good aided blood pressure-lowering hypoglycemic effect, with exclusive use lotus leaf or mulberry leaf phase
Than raising significant in efficacy, illustrate that a few taste bulk pharmaceutical chemicals in pharmaceutical composition of the present invention have played synergistic function, takes for a long time
Pharmaceutical composition of the present invention can be effectively controlled blood glucose and blood pressure, keep it in normal range (NR).Meanwhile pharmaceutical composition of the present invention
Use the medicinal material of integration of drinking and medicinal herbs for bulk pharmaceutical chemicals, pharmacological property is mild, takes for a long time and has no toxic side effect, has a good application prospect.
Claims (10)
1. a kind of pharmaceutical composition that aided blood pressure-lowering is hypoglycemic, it is characterised in that: it is by the bulk pharmaceutical chemicals of following weight proportion
The preparation being prepared: 3~5 parts of lotus leaf, 3~5 parts of mulberry leaf, 1~3 part of cassia seed, 1~3 part of tealeaves, 1~3 part of hawthorn, sophora flower 1
~3 parts, 1~3 part of chrysanthemum.
2. pharmaceutical composition according to claim 1, it is characterised in that: it is prepared by the bulk pharmaceutical chemicals of following weight proportion
Made of preparation: 4 parts of lotus leaf, 4 parts of mulberry leaf, 2 parts of cassia seed, 2 parts of tealeaves, 2 parts of hawthorn, 2 parts of sophora flower, 2 parts of chrysanthemum.
3. pharmaceutical composition according to claim 2, it is characterised in that: the tealeaves is green tea.
4. described in any item pharmaceutical compositions according to claim 1~3, it is characterised in that: it is by each weight proportion raw material
The medicinal powder of medicine, the water of bulk pharmaceutical chemicals or extractive with organic solvent are active constituent, in addition pharmaceutically acceptable auxiliary material is prepared
Preparation.
5. pharmaceutical composition according to claim 4, it is characterised in that: the preparation is oral preparation.
6. pharmaceutical composition according to claim 5, it is characterised in that: the oral preparation is decoction, oral solution, particle
Agent, capsule, tablet, powder, pill, medicinal tea.
7. pharmaceutical composition according to claim 6, it is characterised in that: the medicinal tea is tea bag.
8. a kind of method for preparing the described in any item pharmaceutical compositions of claim 1~7, it is characterised in that: it includes as follows
Step:
(1) each bulk pharmaceutical chemicals are weighed by weight ratio；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, in addition pharmaceutically acceptable auxiliary material
It is prepared into preparation.
9. according to the method described in claim 8, it is characterized by: it includes the following steps:
(1) each bulk pharmaceutical chemicals are weighed by weight ratio；
(2) bulk pharmaceutical chemicals are beaten into powder, packs, is prepared into tea bag.
10. the described in any item pharmaceutical compositions of claim 1~7 are preparing the use in the hypoglycemic drug of aided blood pressure-lowering
On the way.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114098072A (en) * | 2021-10-22 | 2022-03-01 | 长沙四气扁鹊堂健康管理有限公司 | Medicinal and edible material composition and extract for assisting in regulating blood sugar, and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114098072A (en) * | 2021-10-22 | 2022-03-01 | 长沙四气扁鹊堂健康管理有限公司 | Medicinal and edible material composition and extract for assisting in regulating blood sugar, and preparation method and application thereof |
| CN114271361A (en) * | 2021-12-28 | 2022-04-05 | 东莞珍其道健康食品科技有限公司 | Health tea capable of assisting in lowering blood pressure and preparation process thereof |
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