CN105250789A - Hypoglycemic plant fermentation preparation and preparation method thereof - Google Patents
Hypoglycemic plant fermentation preparation and preparation method thereof Download PDFInfo
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- CN105250789A CN105250789A CN201510802913.XA CN201510802913A CN105250789A CN 105250789 A CN105250789 A CN 105250789A CN 201510802913 A CN201510802913 A CN 201510802913A CN 105250789 A CN105250789 A CN 105250789A
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Abstract
The invention discloses a hypoglycemic plant fermentation preparation, which is prepared from the following raw materials in parts by weight: 20-40 parts of mixed paste of mulberry leaves, corn stigma and ganoderma lucidum, 5-10 parts of guava, 5-10 parts of cherry fruit, 5-10 parts of honey pomelo, 5-10 parts of hawthorn fruit, 5-10 parts of strawberry fruit, 5-10 parts of noni, 5-10 parts of bitter gourd and 5-10 parts of Chinese yam. The hypoglycemic plant fermentation preparation disclosed by the invention is good in mouthfeel, good in hypoglycemic effect, free of a toxic or side effect, green and safe, can be easily accepted by a patient, and also has the functions of reducing blood fat and reducing blood pressure.
Description
Technical field
The invention belongs to field of Chinese herbal medicine technology, be specifically related to a kind of blood sugar lowering plant fermentation preparation and preparation method thereof.
Background technology
Diabetes are with blood glucose rising for feature, are lacked or metabolic disease that dysfunction causes carbohydrate metabolism disturbance to cause by insulin secretion.Type 2 diabetes mellitus pathogeny is still imprecise at present, current primary treatments is that oral antidiabetic drug and insulin injection control blood glucose, simple depending on western medicine treatment diabetes are still mainly deposited not enough both ways, and (1) needs lifelong medication, and dosage strengthens year by year; (2) diabetic complication still can not be avoided.
Through studying for a long period of time and clinical practice, developing a kind of blood sugar lowering plant fermentation preparation, there is following characteristics: (1) assistant hypoglycemic is effective, can reduce the dosage of antidiabetic drug and insulin; (2) diabetic complication sickness rate is reduced; (3) mouthfeel is good; (4) green safety.
Summary of the invention
An object of the present invention is to provide a kind of blood sugar lowering plant fermentation preparation, and assistant hypoglycemic is effective, and reduce diabetic complication sickness rate, mouthfeel is good, green safety.
Two of object of the present invention is the preparation method providing this blood sugar lowering plant fermentation preparation.
Blood sugar lowering plant fermentation preparation raw material of the present invention, with weight parts, is made up of following composition:
Folium Mori, Stigma Maydis and Ganoderma mixing unguentum 20-40 part, Fructus psidii guajavae immaturus 5-10 part, Fructus Pruni pseudocerasi 5-10 part, sweet Fructus Citri grandis 5-10 part, Fructus Crataegi 5-10 part, Fructus Fragariae Ananssae 5-10 part, Noni fruit 5-10 part, Fructus Momordicae charantiae 5-10 part, Rhizoma Dioscoreae 5-10 part.
Wherein in Folium Mori, Stigma Maydis and Ganoderma mixing unguentum, Ganoderma unguentum, Folium Mori unguentum and Stigma Maydis unguentum weight ratio are 1:(1.5-3): (2-3).
Wherein preferred 7-10 part of Fructus psidii guajavae immaturus.
Wherein preferred 5-8 part of Fructus Pruni pseudocerasi, the preferred 7-10 part of sweet Fructus Citri grandis.
Wherein preferred 8-10 part of Fructus Crataegi, the preferred 5-7 part of Fructus Fragariae Ananssae.
Wherein preferred 6-10 part of Noni fruit, the preferred 5-7 part of Fructus Momordicae charantiae.
Wherein preferred 8-10 part of Rhizoma Dioscoreae.
The preparation method of blood sugar lowering plant fermentation preparation of the present invention comprises the steps:
(1) preparation of Stigma Maydis unguentum: choose drying, the normal Stigma Maydis of color and luster, remove impurity, clean after, be ground into 60-300 object fine-powdered, be placed in the boiling that 60-80 times of weight boiling water carries out 30-90 minute, cooled and filtered obtains filtrate I, and melt cinder adds the 90-95% alcoholic solution of 1-3 times of weight, lixiviate 40-60 minute at 30-50 DEG C, distilling under reduced pressure obtains filtrate II, and the two mixes and obtains corn stigma extraction liquid, then lixiviating solution is condensed into unguentum;
(2) preparation of Folium Mori unguentum: choosing large and thick, that yellow skin is green, matter is crisp Folium Mori is raw material, add the alcoholic solution of 8-10 90-95% doubly, be heated to 50-70 DEG C, backflow 40-70 minute, cooled and filtered obtains filtrate I, melt cinder adds the alcoholic solution of 5-8 90-95% doubly, be heated to 50-70 DEG C, backflow 40-70 minute, cooled and filtered obtains filtrate II, the two mixes and obtains Folium Mori lixiviating solution, then lixiviating solution is condensed into unguentum;
(3) preparation of Ganoderma unguentum: Ganoderma cleaning powder is broken into 60-300 object fine-powdered, decocting method extracts lixiviating solution, extraction temperature 80-90 degree, extraction time 2-4h, solid-liquid ratio 1:(12-17), then lixiviating solution is condensed into unguentum;
(4) by Ganoderma unguentum, mulberry extract agent and Stigma Maydis unguentum 1:(1.5-3 by weight): the ratio mixing of (2-3);
(5) mixing unguentum and Fructus psidii guajavae immaturus, Fructus Pruni pseudocerasi, sweet Fructus Citri grandis, Fructus Crataegi, Fructus Fragariae Ananssae, Noni fruit, Fructus Momordicae charantiae, Rhizoma Dioscoreae are added probiotic strain to ferment according to fermentation technology flow process, it is 0.3-0.5g/L sodium alginate that fermentation liquid adds stabilizing agent, 0.2-0.6g/L trisodium citrate, 0.3-0.7g/L sodium carboxymethyl cellulose, the tiny particle in mixing juice is removed with kieselguhr, by the preparation constant temperature 100 degree of sterilizings in 20-30 minute after filtration, fills after being cooled to less than 40 degree.
There is a kind of glycosidase inhibitor in Folium Mori, be 1-DNJ (DNJ), by the suppression to glycosidase, thus suppress disaccharidase in the absorption of small intestinal, reduce the peak value of post-prandial glycemia.The alkaloid fagomine contained in Folium Mori and polysaccharides of Folium Mori, can promote the β cells secrete insulin of islets of langerhans.Folium Mori are hypoglycemic while, and the cholesterol level in experimenter's blood also obviously reduces.
Corn silk polysaccharide, Total saponin and Flavonoid substances can increase the utilization of peripheral tissues to glucose, increase the anerobic glycolysis of glucose, reduce gastrointestinal tract to the absorption of glucose.
Ganoderma contains abundant chromium element, and also containing the material that similar insulin is the same in the composition of Ganoderma, Ganoderma can improve body immunity, useful to the complication that prevents diabetes.
Fructus psidii guajavae immaturus, Fructus Pruni pseudocerasi, sweet Fructus Citri grandis, Fructus Crataegi, Fructus Fragariae Ananssae, Noni fruit, Fructus Momordicae charantiae, Rhizoma Dioscoreae coordinate above 3 kinds of compositions, make function of polysaccharide better.
Instructions of taking and the dose of blood sugar lowering plant fermentation preparation of the present invention are as follows:
Blood sugar lowering plant fermentation preparation 10-15ml, every day 3 times, bfore meals.
Blood sugar lowering plant fermentation preparation of the present invention has following effect:
(1) mouthfeel is good, and patient easily accepts for a long time;
(2) hypoglycemic effect is good. also there is blood fat reducing antihypertensive function;
(3) have no side effect, green safety.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.
embodiment 1
Table 1 is the formula of embodiment 1-6 and comparative example 1, and unit is gram
Table 1
Table 2 is the formula of embodiment 7-12 and comparative example 2, and unit is gram
Table 2
The preparation method of the embodiment of the present invention and comparative example blood sugar lowering plant fermentation preparation comprises the steps:
(1) preparation of Stigma Maydis unguentum: choose drying, the normal Stigma Maydis of color and luster, remove impurity, clean after, be ground into 60-300 object fine-powdered, be placed in the boiling that 60-80 times of weight boiling water carries out 30-90 minute, cooled and filtered obtains filtrate I, and melt cinder adds the 90-95% alcoholic solution of 1-3 times of weight, lixiviate 40-60 minute at 30-50 DEG C, distilling under reduced pressure obtains filtrate II, and the two mixes and obtains corn stigma extraction liquid, then lixiviating solution is condensed into unguentum;
(2) preparation of Folium Mori unguentum: choosing large and thick, that yellow skin is green, matter is crisp Folium Mori is raw material, add the alcoholic solution of 8-10 90-95% doubly, be heated to 50-70 DEG C, backflow 40-70 minute, cooled and filtered obtains filtrate I, melt cinder adds the alcoholic solution of 5-8 90-95% doubly, be heated to 50-70 DEG C, backflow 40-70 minute, cooled and filtered obtains filtrate II, the two mixes and obtains Folium Mori lixiviating solution, then lixiviating solution is condensed into unguentum;
(3) preparation of Ganoderma unguentum: Ganoderma cleaning powder is broken into 60-300 object fine-powdered, decocting method extracts lixiviating solution, extraction temperature 80-90 degree, extraction time 2-4h, solid-liquid ratio 1:(12-17), then lixiviating solution is condensed into unguentum;
(4) by Ganoderma unguentum, mulberry extract agent and Stigma Maydis unguentum 1:(1.5-3 by weight): the ratio mixing of (2-3).
(5) mixing unguentum and other raw materials are added probiotic strain to ferment according to fermentation technology flow process, it is 0.3g/L sodium alginate that fermentation liquid adds stabilizing agent, 0.2g/L trisodium citrate, 0.3g/L sodium carboxymethyl cellulose, the tiny particle in mixing juice is removed with kieselguhr, by the preparation constant temperature 100 degree of sterilizings in 20-30 minute after filtration, fills after being cooled to less than 40 degree.
Test one:
Select the diabetics of 53 of hospitalization routine conventional medicine control sugar poor effect, constant at former Therapeutic Method, drink embodiment 1 blood sugar lowering plant fermentation preparation 10ml every day three before the meal, blood sugar lowering plant fermentation preparation is drunk with patient self, front and back are contrast, within 1 month, be 1 course for the treatment of, measure fasting glucose, after the meal 2h sugar respectively.Result: patient is drinking before and after blood sugar lowering plant fermentation preparation, there were significant differences for fasting glucose, after the meal 2h sugar, P<0.01, P<0.05.Conclusion: blood sugar lowering plant fermentation preparation has the effect reducing fasting glucose, after the meal sugar.
Test two:
Product embodiments 1-12 of the present invention, comparative example 1-2 and matched group are carried out clinical verification, and test situation is as follows:
1, object
Select year August in March, 2014 to 2015 the outpatient service of diabetes section and be in hospital 30-60 year type 2 diabetes mellitus patient 150 example, enter to organize the nervous system localizing symptoms of patient without obvious cerebrovas-cularaccident, ordinary electrocardiogram checks without obvious myocardial ischemia or myocardial infarction, without High-grade Proteinuria and renal insufficiency, without proliferative diabetic retinopathy.
2, method
All patients are divided into 15 groups at random according to medical order and sex, often organize 10 people, all carry out diabetes propaganda and education, exercise therapy, oral hypoglycaemic medicine based on Or Metformin In Treating, sulfonylurea drugs treatment be auxiliary (glibenclamide every sheet 2.5mg or glipizide every sheet 5mg or gliquidone 30mg or the every sheet 30mg of Gliclazide sustained-release tablet); Embodiment 1-12 and comparative example 1-2 group patient every day three drink blood sugar lowering plant fermentation preparation 10ml before the meal, manage by diabetic diet; Matched group patient then only adopts Frank diabetes mellitus diet.
Blood pressure (Bp), fasting glucose (FBG), fasting insulin (FINS), triglyceride (TG), low density lipoprotein, LDL (LDL), the high density lipoprotein (HDL) of patient is measured, in the medicining condition of 12 weeks statistics patients in 0,12 week.
3, result
Clinical and laboratory data before (1) 15 group of patient treatment
The situation difference nonsignificance (P > 0.05) such as body weight, Bp, sugar, fat between 15 groups before age, diabetic duration, men and women's ratio and test, has comparability, refers to table 3.
Clinical and laboratory data (x ± s) before table 315 group patient treatment
Table 3(continued)
Clinical and test chamber data after above 15 groups of treatments is in table 4
Clinical and laboratory data (x ± s) after table 415 group patient treatment
Table 4(continued)
Result of the test shows: the present invention obviously can alleviate the body weight of overweight type 2 diabetes mellitus patient, is more conducive to patient's sugar, the metabolism of fat and hypertensive control, is also conducive to adhering to of patient's oral hypoglycaemic medicine treatment.
Claims (8)
1. a blood sugar lowering plant fermentation preparation, its raw material is with weight parts, be made up of following composition: Folium Mori, Stigma Maydis and Ganoderma mixing unguentum 20-40 part, Fructus psidii guajavae immaturus 5-10 part, Fructus Pruni pseudocerasi 5-10 part, honey Fructus Citri grandis 5-10 part, Fructus Crataegi 5-10 part, Fructus Fragariae Ananssae 5-10 part, Noni fruit 5-10 part, Fructus Momordicae charantiae 5-10 part, Rhizoma Dioscoreae 5-10 part.
2. blood sugar lowering plant fermentation preparation according to claim 1, is characterized in that in described Folium Mori, Stigma Maydis and Ganoderma mixing unguentum, Ganoderma unguentum, Folium Mori unguentum and Stigma Maydis unguentum weight ratio are 1:(1.5-3): (2-3).
3. blood sugar lowering plant fermentation preparation according to claim 1, is characterized in that described Fructus psidii guajavae immaturus is 7-10 part.
4. blood sugar lowering plant fermentation preparation according to claim 1, it is characterized in that described Fructus Pruni pseudocerasi is 5-8 part, described sweet Fructus Citri grandis is 7-10 part.
5. blood sugar lowering plant fermentation preparation according to claim 1, it is characterized in that described Fructus Crataegi is 8-10 part, Fructus Fragariae Ananssae is 5-7 part.
6. blood sugar lowering plant fermentation preparation according to claim 1, it is characterized in that described Noni fruit is 6-10 part, Fructus Momordicae charantiae is 5-7 part.
7. blood sugar lowering plant fermentation preparation according to claim 1, is characterized in that described Rhizoma Dioscoreae is 8-10 part.
8. the preparation method of blood sugar lowering plant fermentation preparation according to claim 1, is characterized in that in turn including the following steps:
(1) preparation of Stigma Maydis unguentum: Stigma Maydis is ground into 60-300 object fine-powdered, be placed in the boiling that 60-80 times of weight boiling water carries out 30-90 minute, cooled and filtered obtains filtrate I, melt cinder adds the 90-95% alcoholic solution of 1-3 times of weight, lixiviate 40-60 minute at 30-50 DEG C, distilling under reduced pressure obtains filtrate II, and the two mixes and obtains corn stigma extraction liquid, then lixiviating solution is condensed into unguentum;
(2) preparation of Folium Mori unguentum: alcoholic solution Folium Mori being added the 90-95% of 8-10 times of weight, be heated to 50-70 DEG C, backflow 40-70 minute, cooled and filtered obtains filtrate I, and melt cinder adds the alcoholic solution of 5-8 90-95% doubly, is heated to 50-70 DEG C, backflow 40-70 minute, cooled and filtered obtains filtrate II, and the two mixes and obtains Folium Mori lixiviating solution, then lixiviating solution is condensed into unguentum;
(3) preparation of Ganoderma unguentum: Ganoderma cleaning powder is broken into 60-300 object fine-powdered, decocting method extracts lixiviating solution, extraction temperature 80-90 degree, extraction time 2-4h, solid-liquid ratio 1:(12-17), then lixiviating solution is condensed into unguentum;
(4) by Ganoderma unguentum, mulberry extract agent and Stigma Maydis unguentum 1:(1.5-3 by weight): the ratio mixing of (2-3);
(5) mixing unguentum and Fructus psidii guajavae immaturus, Fructus Pruni pseudocerasi, sweet Fructus Citri grandis, Fructus Crataegi, Fructus Fragariae Ananssae, Noni fruit, Fructus Momordicae charantiae, Rhizoma Dioscoreae are added probiotic strain to ferment according to fermentation technology flow process, it is 0.3-0.5g/L sodium alginate that fermentation liquid adds stabilizing agent, 0.2-0.6g/L trisodium citrate, 0.3-0.7g/L sodium carboxymethyl cellulose, the tiny particle in mixing juice is removed with kieselguhr, by the preparation constant temperature 100 degree of sterilizings in 20-30 minute after filtration, fills after being cooled to less than 40 degree.
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Cited By (7)
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| CN106389780A (en) * | 2016-12-06 | 2017-02-15 | 衡阳茂晨农业开发有限公司 | Drug combination capable of preventing and controlling ascites of pig frogs and preparation method of drug combination |
| CN106421495A (en) * | 2016-12-06 | 2017-02-22 | 衡阳茂晨农业开发有限公司 | Medicine for preventing and treating ascites disease of Rana grylio and preparation method thereof |
| CN106474311A (en) * | 2016-12-06 | 2017-03-08 | 衡阳茂晨农业开发有限公司 | Preventing and treating Chinese medicine composition of Rana grylia Ascites Disease and preparation method thereof |
| CN106491906A (en) * | 2016-12-11 | 2017-03-15 | 衡阳县轩健农牧发展有限公司 | A kind of Chinese medicine composition of preventing and treating pig erysipelas and preparation method thereof |
| CN106491907A (en) * | 2016-12-11 | 2017-03-15 | 衡阳县轩健农牧发展有限公司 | Medicine of preventing and treating pig erysipelas and preparation method thereof |
| CN110537559A (en) * | 2019-08-30 | 2019-12-06 | 武汉轻工大学 | Low-GI light-eating frozen sweet dough and preparation method thereof and frozen sweet dough bread |
| CN116459296A (en) * | 2023-04-23 | 2023-07-21 | 广东省科学院生物与医学工程研究所 | Preparation method of ganoderma morinda citrifolia probiotic pills |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389780A (en) * | 2016-12-06 | 2017-02-15 | 衡阳茂晨农业开发有限公司 | Drug combination capable of preventing and controlling ascites of pig frogs and preparation method of drug combination |
| CN106421495A (en) * | 2016-12-06 | 2017-02-22 | 衡阳茂晨农业开发有限公司 | Medicine for preventing and treating ascites disease of Rana grylio and preparation method thereof |
| CN106474311A (en) * | 2016-12-06 | 2017-03-08 | 衡阳茂晨农业开发有限公司 | Preventing and treating Chinese medicine composition of Rana grylia Ascites Disease and preparation method thereof |
| CN106491906A (en) * | 2016-12-11 | 2017-03-15 | 衡阳县轩健农牧发展有限公司 | A kind of Chinese medicine composition of preventing and treating pig erysipelas and preparation method thereof |
| CN106491907A (en) * | 2016-12-11 | 2017-03-15 | 衡阳县轩健农牧发展有限公司 | Medicine of preventing and treating pig erysipelas and preparation method thereof |
| CN110537559A (en) * | 2019-08-30 | 2019-12-06 | 武汉轻工大学 | Low-GI light-eating frozen sweet dough and preparation method thereof and frozen sweet dough bread |
| CN116459296A (en) * | 2023-04-23 | 2023-07-21 | 广东省科学院生物与医学工程研究所 | Preparation method of ganoderma morinda citrifolia probiotic pills |
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