CN102940800A - Traditional Chinese medicine for treating diabetes - Google Patents
Traditional Chinese medicine for treating diabetes Download PDFInfo
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- CN102940800A CN102940800A CN2012104431888A CN201210443188A CN102940800A CN 102940800 A CN102940800 A CN 102940800A CN 2012104431888 A CN2012104431888 A CN 2012104431888A CN 201210443188 A CN201210443188 A CN 201210443188A CN 102940800 A CN102940800 A CN 102940800A
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Abstract
The invention discloses a traditional Chinese medicine for treating diabetes. The traditional Chinese medicine is characterized by being prepared from the following traditional Chinese medicine raw medicinal materials in parts by weight: 10-21 parts of agrimony, 10-13 parts of Dangshen, 3-12 parts of colla corii asini, 10-15 parts of schisandra fruit, 3-12 parts of huai rhizoma dioscoreae, 2-5 parts of notoginseng powder, 10-30 parts of rhizoma anemarrhenae, 10-15 parts of milkvetch root, 10-15 parts of unprocessed rehmannia root, 10-15 parts of medlar, 10-15 parts of corn silk, 3-12 parts of angelica and 5-10 parts of kudzuvine root. According to the traditional Chinese medicine for treating the diabetes, symptoms can be alleviated and the blood sugar can be reduced in a short time after the patients take the medicine, and side effects, such as hypoglycemia and injury to organs, such as kidneys, livers, spleens, cannot occur in long-term application; and meanwhile, the traditional Chinese medicine has the characteristics of fast effect, pharmacodynamic exactness, simple and feasible process, and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine for the treatment of diabetes.Belong to drug world.
Background technology
" diabetes " are the diseases of the easy overheap of glucose in a kind of blood.Give its another name " reticent killer " (Silent Killer), particularly " adult diabetes mellitus " abroad.It is high especially that middle age more than 40 years old is caught rate, in case suffer from " diabetes ", will reduce 10 years more than life-span, and contingent complication spreads all over whole body.The diabetes of diabetes (Diabetes) minute type 1 diabetes, type 2 diabetes mellitus, gestational diabetes and other specific types.In diabetics, the shared ratio of type 2 diabetes mellitus is about 95%.China is existing diabetics more than 4,000 ten thousand at present, occupies the second in the world, and wherein 95% is 2 types, and diabetics needs lifelong medication.Therefore, exploitation treatment type 2 diabetes mellitus new drug efficient, long-acting, at a low price is significant.Traditional sulfonylurea, the treatment of the oral hypoglycemics such as biguanides, but the most outstanding untoward reaction of these medicines is exactly hypoglycemia, and may bring out the body weight increase, make its clinical practice limited, to kidney, liver, the organs such as spleen bring side effect, also there are many drawbacks in the Chinese medicine preparation of current treatment, therapeutic effect is not obvious, the onset diabetes rate worldwide climbs up and up in addition, existing medicine can't satisfy the future market demand, therefore, form mechanism for disease, seek and develop safer and more effective newtype drug and be imminent to prevent and to reverse the PD of type 2 diabetes mellitus, just to seem.Desirable treatment diabetes medicament is in blood sugar lowering; should protect islet cell function as far as possible; reduce hyperglycemia; improve the secretion of endogenous insulin; improve surrounding tissue to the sensitivity of insulin; promote sugar and lipid metabolism and increase the dependence on the glucose insulin secretion, can not occur the side effect such as organ such as hypoglycemia and damage kidney,liver,spleen during prolonged application.
Summary of the invention
Purpose of the present invention provides a kind of Chinese medicine for the treatment of diabetes evident in efficacy for above-mentioned deficiency.The patient can make symptom be eased after taking this medicine in a short time, and the side effect such as organ such as hypoglycemia and damage kidney,liver,spleen can not appear in blood sugar lowering during prolonged application; Simultaneously, also have instant effect, drug effect is definite, the characteristics such as technique simple possible.
Technical solution of the present invention is: the Chinese medicine for the treatment of diabetes, it is characterized in that: it is formulated by following weight parts raw material of Chinese medicine medicine: Herba Agrimoniae 10-21 part, Radix Codonopsis 10-13 part, Colla Corii Asini 3-12 part, Fructus Schisandrae Chinensis 10-15 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 3-12 part, Radix Notoginseng powder 2-5 part, Rhizoma Anemarrhenae 10-30 part, Radix Astragali 10-15 part, Radix Rehmanniae 10-15 part, Fructus Lycii 10-15 part, Stigma Maydis 10-15 part, Radix Angelicae Sinensis 3-12 part, Radix Puerariae 5-10 part.
The Chinese medicine optimum formula of described treatment diabetes is formulated by following weight parts raw material of Chinese medicine medicine:
15 parts of Herba Agrimoniaes, 12 parts of Radix Codonopsis, 7 parts in Colla Corii Asini, 12 parts of Fructus Schisandrae Chinensis, 8 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 3 parts of Radix Notoginseng powder, 16 parts of the Rhizoma Anemarrhenaes, 13 parts of the Radixs Astragali, 11 parts of Radix Rehmanniae, 11 parts of Fructus Lycii, 12 parts of Stigma Maydis, 9 parts of Radix Angelicae Sinensis, 7 parts of Radix Puerariaes.
The preparation method of the Chinese medicine of described treatment diabetes is characterized in that: the method comprises the steps:
1), take by weighing raw material by following weight portion:
Herba Agrimoniae 10-21 part, Radix Codonopsis 10-13 part, Colla Corii Asini 3-12 part, Fructus Schisandrae Chinensis 10-15 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 3-12 part, Radix Notoginseng powder 2-5 part, Rhizoma Anemarrhenae 10-30 part, Radix Astragali 10-15 part, Radix Rehmanniae 10-15 part, Fructus Lycii 10-15 part, Stigma Maydis 10-15 part, Radix Angelicae Sinensis 3-12 part, Radix Puerariae 5-10 part;
2), the Radix Astragali, Radix Codonopsis, Colla Corii Asini of getting above-mentioned weight portion be ground into fine powder after mixing, and filters through 100 mesh filter screens, gets mixed dust formulation;
3) Herba Agrimoniae, Fructus Schisandrae Chinensis, RHIIZOMA DIOSCOREAE fr0m Henan of China, the Rhizoma Anemarrhenae, Radix Rehmanniae, Fructus Lycii, Stigma Maydis, Radix Angelicae Sinensis, the Radix Puerariae of, getting above-mentioned weight portion decoct with water twice, each 1.5 hours, gradation is filtered, and merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;
4), thick paste and step 2 that step 3) is obtained) mixed dust formulation mixes, dry, as to pulverize, add above-mentioned weight portion Radix Notoginseng powder, mixing, granulation, drying, packing and get final product.
Oral during treatment, 3 times on the one, one month is a course for the treatment of.Take effect after the course for the treatment of, effect is remarkable after three treatments, has no side effect.
Characteristics of the present invention are reasonable recipe, meet theory of Chinese medical science: Herba Agrimoniae is puckery, the convergence tonify deficiency, and hemorrhage ending, impairment caused by overstrain can heal; Radix Codonopsis is sweet flat, and invigorating the spleen and replenishing QI is slaked thirst and help produce saliva, and domination of pathogen person avoids; Colla Corii Asini is sweet flat, and the cough-relieving pus and blood is spitted blood and collapsed tire, and empty win can be sobbed; The trimethyl gallic acid temperature, promoting the production of body fluid to quench thirst, the chronic cough asthenia, the lung kidney is exhausted; Rhizoma dioscoreae, another name: RHIIZOMA DIOSCOREAE fr0m Henan of China, Gan Wen, regulating qi-flowing for strengthening spleen, the kidney tonifying invigorating middle warmer, all void can be controlled; The Radix Notoginseng powder temperature, the sharp stasis of blood of stopping blooding, the empty pain of detumescence; Rhizoma Anemarrhenae bitter in the mouth, heat can remove yearningly, and hectic fever due to YIN-deficiency has antiperspirant, and productive cough can be relaxed.The Radix Astragali: modern medicine proves that Chinese medicine astragalus has the insulin sensitivity of increasing and hypoglycemic effect to diabetics.Radix Rehmanniae: the effect of nourishing YIN and clearing away heat is arranged.Calculate by per kilogram of body weight 2g, feed laboratory animal, blood glucose is obviously descended, also can suppress and prevent the rabbit blood glucose rising due to the epinephrine, and can improve hyperlipidemia, the hypertension state of an illness of glycosuria.Fructus Lycii: Fructus Lycii also is hypoglycemic Chinese medicine, and the kidney invigorating nourishing the liver, is quenched one's thirst etc. at the treating the liver deficiency of the kidney yin.Stigma Maydis: the Stigma Maydis leaven has obvious hypoglycemic activity to the laboratory animal diabetes, and glycosuria hypertension, nephropathy are improved effect.Radix Angelicae Sinensis: can enrich blood invigorate blood circulation, loosening bowel to relieve constipation, have the liver protecting, prevent that hepatic glycogen from reducing, the effect of calm, analgesia and antiinflammatory.Radix Puerariae: but this product relieving muscles diaphoresis, invigorating YANG QI to promote eruption, analgesic promoting the production of body fluid have aobvious hypoglycemic activity.Chinese medicine of the present invention has stable curative effect, can not occur the side effect such as organ such as hypoglycemia and damage kidney,liver,spleen during prolonged application; Simultaneously, also has instant effect, the characteristics such as technique simple possible.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail, but not as a limitation of the invention.
Embodiment 1
1), take by weighing raw material by following weight:
Herba Agrimoniae 15g, Radix Codonopsis 12g, Colla Corii Asini 7g, Fructus Schisandrae Chinensis 12g, RHIIZOMA DIOSCOREAE fr0m Henan of China 8g, Radix Notoginseng powder 3g, Rhizoma Anemarrhenae 16g, Radix Astragali 13g, Radix Rehmanniae 11g, Fructus Lycii 11g, Stigma Maydis 12g, Radix Angelicae Sinensis 9g, Radix Puerariae 7g;
2), the Radix Astragali, Radix Codonopsis, Colla Corii Asini of getting above-mentioned weight be ground into fine powder after mixing, and filters through 100 mesh filter screens, gets mixed dust formulation;
3) Herba Agrimoniae, Fructus Schisandrae Chinensis, RHIIZOMA DIOSCOREAE fr0m Henan of China, the Rhizoma Anemarrhenae, Radix Rehmanniae, Fructus Lycii, Stigma Maydis, Radix Angelicae Sinensis, the Radix Puerariae of, getting above-mentioned weight decoct with water twice, each 1.5 hours, gradation is filtered, and merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;
4), thick paste and step 2 that step 3) is obtained) mixed dust formulation mixes, dry, as to pulverize, add above-mentioned weight Radix Notoginseng powder, mixing, granulation, drying, packing and get final product.
[usage and dosage] is oral.A 6g, 3 times on the one; Or follow the doctor's advice.
[specification] every packed 6g
Embodiment 2
Herba Agrimoniae 21g, Radix Codonopsis 13g, Colla Corii Asini 12g, Fructus Schisandrae Chinensis 15g, RHIIZOMA DIOSCOREAE fr0m Henan of China 12g, Radix Notoginseng powder 5g, Rhizoma Anemarrhenae 30g, Radix Astragali 15g, Radix Rehmanniae 15g, Fructus Lycii 15g, Stigma Maydis 15g, Radix Angelicae Sinensis 12g, Radix Puerariae 10g.
Preparation, usage and dosage and specification are with embodiment 1.
Embodiment 3
Herba Agrimoniae 10g, Radix Codonopsis 10g, Colla Corii Asini 3g, Fructus Schisandrae Chinensis 10g, RHIIZOMA DIOSCOREAE fr0m Henan of China 3g, Radix Notoginseng powder 2g, Rhizoma Anemarrhenae 10g, Radix Astragali 10g, Radix Rehmanniae 10g, Fructus Lycii 10g, Stigma Maydis 10g, Radix Angelicae Sinensis 3g, Radix Puerariae 5g.
Preparation, usage and dosage and specification are with embodiment 1.
Adopt the made preparation of Chinese medicine formula for the treatment of diabetes of the present invention, preferably the electuary preparation.Also can be that each medicinal component also can be mixed and made into pharmaceutical carrier or additive common dosage forms in the pharmacy such as tablet, pill, oral liquid, capsule.
In order to show the therapeutic effect of medicine of the present invention, the present invention has carried out pharmacodynamics test and clinical trial.
The pharmacodynamics test of the Chinese medicine for the treatment of diabetes proposed by the invention is as follows:
1, hypoglycemic activity
Healthy kunming mice (cleaning level, Experimental Animal Center provides);
D-Glucose (1.5g/kg), 0.9%Nacl solution, the medicine of the embodiment of the invention 1;
Full-automatic blood glucose meter (German Luo Shi diagnostic companies, the full TM vigor of Luo Kang type blood-sugar detecting instrument)
Healthy kunming mice, male and female half and half, the male and female collocation is divided into 4 groups, and 6 every group, fasting 16-18 hour, 1) the normal saline matched group; 2) SHENSHI JIANGTANG JIAONANG matched group; 3) metformin hydrochloride tablet matched group; 4) the medicine group of the embodiment of the invention 1;
Each gives respectively glucose load (1.5 g/kg) after organizing respectively administration 15 min, is designated as 0 when giving sugar constantly.Get blood respectively at 5,10,20,30,60,90,120,150 min from mouse tail vein, measure blood glucose value with blood glucose meter.For the long-time medicine hypoglycemic activity of observing the embodiment of the invention 1, when 150 min, again give immediately D-Glucose (1.5 mg/kg) behind the tail venous blood sampling, press same time measuring space blood glucose.
Experiment shows that the medicine glucose load animal of the embodiment of the invention 1 gives rear 120 minutes blood sugar recoveries of sugar to normal level in gavage.Glucose load (1.5 g/kg) for the second time, the medicine of the embodiment of the invention 1 is still brought into play its blood sugar reducing function.The above results shows that the medicine of the embodiment of the invention 1 can obviously improve mice to the toleration of sugar, does not reduce euglycemia, and dependency reduced hyperglycemia, stimulated insulin secretion, and its blood sugar reducing function can be kept more than 3 h.
2, suppress to ingest, slimming effect
C57BL/6 mice (SPF level, Experimental Animal Center provides);
Spontaneous Diabetic db/db mice (SPF level, Nanjing University's country pattern Institute of Botany provides); 0.9%Nacl solution, the medicine group of the embodiment of the invention 1;
Healthy C57BL/6 mice and Spontaneous Diabetic db/db mice respectively are divided into 2 groups (n=6-10).1. normal saline matched group; 2. the medicine group of the embodiment of the invention 1.
Each was organized in every morning 9:00 and 6:00 administration in afternoon, 7 weeks of successive administration. measure food ration and the body weight of each treated animal during 11:00 respectively at morning every day.
The result demonstrates, and the medicine group of the embodiment of the invention 1 can obviously reduce the food ration of diabetic mice in the administration process in 7 weeks by a definite date, and reduces the body weight of diabetic mice, but to healthy mice ingest and body weight has no significant effect.This shows that the medicine group of the embodiment of the invention 1 can be used for controlling the caused obesity symptom of diabetes to a certain extent.
It is consistent to adopt simultaneously the embodiment of the invention 2 and 3 to be its result of above-mentioned experiment.
The clinical trial of the Chinese medicine for the treatment of diabetes proposed by the invention is as follows:
Select age 48-58 year patient 120 examples, 53 years old mean age, course of disease April-1 year, average course of disease 7 months.The patient did not accept other treatment before this treatment, minute 3 periods: on an empty stomach, 2 hours after the meal, at random, survey its blood glucose and all exceed normal value.30 days is a course for the treatment of, carries out symptom score after 30 days.Among the 120 routine patients, 20 examples (being called treatment group 1) adopt the medicine of the embodiment of the invention 1; 20 examples (being called treatment group 2) adopt the medicine of the embodiment of the invention 2; 20 examples (being called treatment group 3) adopt the medicine of the embodiment of the invention 3; 20 examples (being called contrast A group) adopt metformin hydrochloride tablet; 20 examples (being called contrast B group) adopt SHENSHI JIANGTANG JIAONANG; 20 examples (being called contrast C group) are not carried out Drug therapy, but be careful in one's diet control and exercise.The zest environment is avoided in during this time patient's smoking cessation, is careful in one's diet and has a rest.
Adopt metformin hydrochloride tablet and SHENSHI JIANGTANG JIAONANG using method to be: one day 3 times, each a slice or one.
Diagnostic criteria
Adopt ADA diabetes diagnosis standard in 2010:
1. glycosated Hb A 1c 〉=6.5%*;
2. fasting glucose FPG 〉=7.0 mmol/l.Be defined as on an empty stomach at least interior empty calory absorption of 8h *;
3. 2h blood glucose 〉=11.1 mmol/l* during the oral glucose tolerance test;
4. at the patient with typical hyperglycemia or hyperglycemia crisis symptom, random blood sugar 〉=11.1 mmol/l;
* without clear and definite hyperglycemia the time, should come confirmation standard 1 ~ 3 by duplicate detection;
Criterion is:
Recovery from illness: be lower than diagnostic criteria;
Produce effects: decrease than the blood glucose value of surveying before the treatment after the treatment;
Effectively: than the front blood glucose value of surveying for the treatment of obvious reduction is arranged after the treatment and near normal value;
Invalid: after the treatment than treatment front to survey blood glucose value unchanged.
Therapeutic outcome:
Table 1 embodiment of the invention 1 treatment effect comparison after 30 days
Group | N number (people) | Recovery from illness (people) | Produce effects (people) | Effectively (people) | Invalid (people) |
Treatment group 1 | 20 | 10 | 2 | 8 | 0 |
Treatment group 2 | 20 | 10 | 4 | 6 | 0 |
Treatment group 3 | 20 | 9 | 3 | 8 | 0 |
Contrast A group | 20 | 7 | 2 | 10 | 1 |
Contrast B group | 20 | 6 | 7 | 6 | 1 |
Contrast C group | 20 | 0 | 2 | 0 | 18 |
By as seen from Table 1, adopt the treatment group 1-3 recovery from illness number of the made Chinese medicine of the present invention to be higher than contrast A, B and C group, invalid number is zero.The result shows that the whole structure of the treatment of using treatment group 1-3 is good.Wherein, adopt the best results of the treatment group 1 of embodiment 1.
Claims (3)
1. treat the Chinese medicine of diabetes, it is characterized in that: it is formulated by following weight parts raw material of Chinese medicine medicine: Herba Agrimoniae 10-21 part, Radix Codonopsis 10-13 part, Colla Corii Asini 3-12 part, Fructus Schisandrae Chinensis 10-15 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 3-12 part, Radix Notoginseng powder 2-5 part, Rhizoma Anemarrhenae 10-30 part, Radix Astragali 10-15 part, Radix Rehmanniae 10-15 part, Fructus Lycii 10-15 part, Stigma Maydis 10-15 part, Radix Angelicae Sinensis 3-12 part, Radix Puerariae 5-10 part.
2. the Chinese medicine for the treatment of diabetes according to claim 1, it is characterized in that: it is formulated by following weight parts raw material of Chinese medicine medicine:
15 parts of Herba Agrimoniaes, 12 parts of Radix Codonopsis, 7 parts in Colla Corii Asini, 12 parts of Fructus Schisandrae Chinensis, 8 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 3 parts of Radix Notoginseng powder, 16 parts of the Rhizoma Anemarrhenaes, 13 parts of the Radixs Astragali, 11 parts of Radix Rehmanniae, 11 parts of Fructus Lycii, 12 parts of Stigma Maydis, 9 parts of Radix Angelicae Sinensis, 7 parts of Radix Puerariaes.
3. the preparation method of the Chinese medicine for the treatment of diabetes according to claim 1, it is characterized in that: the method comprises the steps:
1), take by weighing raw material by following weight portion:
Herba Agrimoniae 10-21 part, Radix Codonopsis 10-13 part, Colla Corii Asini 3-12 part, Fructus Schisandrae Chinensis 10-15 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 3-12 part, Radix Notoginseng powder 2-5 part, Rhizoma Anemarrhenae 10-30 part, Radix Astragali 10-15 part, Radix Rehmanniae 10-15 part, Fructus Lycii 10-15 part, Stigma Maydis 10-15 part, Radix Angelicae Sinensis 3-12 part, Radix Puerariae 5-10 part;
2), the Radix Astragali, Radix Codonopsis, Colla Corii Asini of getting above-mentioned weight portion be ground into fine powder after mixing, and filters through 100 mesh filter screens, gets mixed dust formulation;
3) Herba Agrimoniae, Fructus Schisandrae Chinensis, RHIIZOMA DIOSCOREAE fr0m Henan of China, the Rhizoma Anemarrhenae, Radix Rehmanniae, Fructus Lycii, Stigma Maydis, Radix Angelicae Sinensis, the Radix Puerariae of, getting above-mentioned weight portion decoct with water twice, each 1.5 hours, gradation is filtered, and merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;
4), thick paste and step 2 that step 3) is obtained) mixed dust formulation mixes, dry, as to pulverize, add above-mentioned weight portion Radix Notoginseng powder, mixing, granulation, drying, packing and get final product.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104782848A (en) * | 2015-05-11 | 2015-07-22 | 广西梧州茂圣茶业有限公司 | Liubao (Chinese character) tea-containing composition with hypoglycemic function |
CN105077467A (en) * | 2015-07-05 | 2015-11-25 | 青岛浩大海洋保健食品有限公司 | Health-care abalone-sea cucumber beverage with blood sugar-reducing function |
CN106070820A (en) * | 2016-08-15 | 2016-11-09 | 陈德忠 | A kind of Chinese medicine blood sugar lowering tea |
CN114982713A (en) * | 2022-06-09 | 2022-09-02 | 辽宁中医药大学 | Construction method, evaluation method and application of yin deficiency syndrome and symptom combined animal model of type 2 diabetes |
-
2012
- 2012-11-08 CN CN2012104431888A patent/CN102940800A/en not_active Withdrawn
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104782848A (en) * | 2015-05-11 | 2015-07-22 | 广西梧州茂圣茶业有限公司 | Liubao (Chinese character) tea-containing composition with hypoglycemic function |
CN105077467A (en) * | 2015-07-05 | 2015-11-25 | 青岛浩大海洋保健食品有限公司 | Health-care abalone-sea cucumber beverage with blood sugar-reducing function |
CN106070820A (en) * | 2016-08-15 | 2016-11-09 | 陈德忠 | A kind of Chinese medicine blood sugar lowering tea |
CN114982713A (en) * | 2022-06-09 | 2022-09-02 | 辽宁中医药大学 | Construction method, evaluation method and application of yin deficiency syndrome and symptom combined animal model of type 2 diabetes |
CN114982713B (en) * | 2022-06-09 | 2024-01-19 | 辽宁中医药大学 | Construction method, evaluation method and application of model combining yin deficiency syndrome type 2 diabetes with animal |
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Application publication date: 20130227 |