CN106072099A - A kind of health food of auxiliary reducing blood lipid containing green plum and preparation method thereof - Google Patents
A kind of health food of auxiliary reducing blood lipid containing green plum and preparation method thereof Download PDFInfo
- Publication number
- CN106072099A CN106072099A CN201610395383.6A CN201610395383A CN106072099A CN 106072099 A CN106072099 A CN 106072099A CN 201610395383 A CN201610395383 A CN 201610395383A CN 106072099 A CN106072099 A CN 106072099A
- Authority
- CN
- China
- Prior art keywords
- parts
- green plum
- extract
- health food
- reducing blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 48
- 239000008280 blood Substances 0.000 title claims abstract description 48
- 235000013402 health food Nutrition 0.000 title claims abstract description 40
- 150000002632 lipids Chemical class 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 22
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 22
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 22
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 22
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 22
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 22
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 22
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 22
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 22
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 22
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 22
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 22
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 22
- 235000005412 red sage Nutrition 0.000 claims abstract description 22
- 241000222336 Ganoderma Species 0.000 claims abstract description 20
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 19
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 235000013305 food Nutrition 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 42
- 235000012054 meals Nutrition 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000000605 extraction Methods 0.000 claims description 14
- 238000010992 reflux Methods 0.000 claims description 13
- 238000005516 engineering process Methods 0.000 claims description 12
- 239000002002 slurry Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 9
- 230000006837 decompression Effects 0.000 claims description 7
- 241000411851 herbal medicine Species 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- 238000005202 decontamination Methods 0.000 claims description 6
- 230000003588 decontaminative effect Effects 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 4
- 238000004821 distillation Methods 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 241001092040 Crataegus Species 0.000 claims 6
- 241000233948 Typha Species 0.000 claims 6
- 230000000694 effects Effects 0.000 abstract description 23
- 240000000171 Crataegus monogyna Species 0.000 abstract description 16
- 231100000331 toxic Toxicity 0.000 abstract description 7
- 230000002588 toxic effect Effects 0.000 abstract description 7
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 230000004087 circulation Effects 0.000 abstract description 3
- 230000002175 menstrual effect Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 210000004243 sweat Anatomy 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 2
- 230000001939 inductive effect Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 240000001398 Typha domingensis Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 17
- 240000000260 Typha latifolia Species 0.000 description 15
- 229940079593 drug Drugs 0.000 description 13
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 12
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 208000031226 Hyperlipidaemia Diseases 0.000 description 6
- FQCKMBLVYCEXJB-MNSAWQCASA-L atorvastatin calcium Chemical compound [Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 FQCKMBLVYCEXJB-MNSAWQCASA-L 0.000 description 6
- 235000012000 cholesterol Nutrition 0.000 description 6
- 229940002661 lipitor Drugs 0.000 description 6
- 150000003626 triacylglycerols Chemical class 0.000 description 6
- 108010023302 HDL Cholesterol Proteins 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 108010028554 LDL Cholesterol Proteins 0.000 description 4
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical group O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 240000007311 Commiphora myrrha Species 0.000 description 3
- 235000006965 Commiphora myrrha Nutrition 0.000 description 3
- 235000007265 Myrrhis odorata Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 230000003143 atherosclerotic effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- YEFOAORQXAOVJQ-RZFZLAGVSA-N schisandrol a Chemical compound C1[C@H](C)[C@@](C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-RZFZLAGVSA-N 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- BKGUPIVDQHHVMV-LSHKVNPSSA-N 64938-51-8 Chemical group COC1=C2C=3C(OC)=C(OC)C(OC)=CC=3[C@H](OC(=O)C(\C)=C\C)[C@@](C)(O)[C@@H](C)CC2=CC2=C1OCO2 BKGUPIVDQHHVMV-LSHKVNPSSA-N 0.000 description 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 244000302512 Momordica charantia Species 0.000 description 1
- 235000009811 Momordica charantia Nutrition 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000018795 Prunus mume Species 0.000 description 1
- 235000011158 Prunus mume Nutrition 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 206010039020 Rhabdomyolysis Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010048214 Xanthoma Diseases 0.000 description 1
- 206010048215 Xanthomatosis Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000489 anti-atherogenic effect Effects 0.000 description 1
- 230000002402 anti-lipaemic effect Effects 0.000 description 1
- 229960005370 atorvastatin Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940099352 cholate Drugs 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000019564 dysgeusia Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 229940125753 fibrate Drugs 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 230000009395 genetic defect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- BKGUPIVDQHHVMV-UHFFFAOYSA-N schisantherin C Natural products COC1=C2C=3C(OC)=C(OC)C(OC)=CC=3C(OC(=O)C(C)=CC)C(C)(O)C(C)CC2=CC2=C1OCO2 BKGUPIVDQHHVMV-UHFFFAOYSA-N 0.000 description 1
- 229930193195 schizandrin Natural products 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000020097 white wine Nutrition 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- YEFOAORQXAOVJQ-UHFFFAOYSA-N wuweizischun A Natural products C1C(C)C(C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to field of health care products, be specifically related to a kind of health food of auxiliary reducing blood lipid containing green plum and preparation method thereof.Said composition is prepared from by the raw material of following parts by weight: 18 35 parts of green plum, rhizoma alismatis 10 22 parts, the red sage root 6 18 parts, safron 8 12 parts, excrementum pteropi 10 18 parts, cattail pollen 28 parts, the fleece-flower root 12 20 parts, wild pseudo-ginseng 4 10 parts, radix bupleuri 4 10 parts, hawthorn 28 parts, glossy ganoderma 4 10 parts and 12 24 parts of Radix Glycyrrhizae.The health-care food composition compatibility that the present invention provides rationally, science, each component Synergistic, the effects such as having invigorates blood circulation stimulates the menstrual flow, and promoting the circulation of qi dissipates the stasis of blood, Huayu Tonglin, and in inducing sweat, clearing heat and detoxicating.Animal experiment shows, health food of the present invention has the effect significantly assisting reducing blood lipid, and its toxic and side effect is little, security is high.
Description
Technical field
The invention belongs to field of health care products, be specifically related to health food and the preparation thereof of a kind of auxiliary reducing blood lipid containing green plum
Method.
Background technology
With socio-economic development, growth in the living standard, the life style of people all there occurs huge change.High blood
Fat, high cholesterol, hypertension, hyperglycaemia, fatty liver are increasingly becoming popular pandemic.
Blood fat is neutral fat (triglycerides and cholesterol) and lipoid (phosphatide, glycolipid, sterol, steroids) in blood plasma
General name, be the required material of basic metabolism of life cells.Lipids contents can be with the situation of antimer lipid metabolism.
In blood plasma, cholesterol or the abnormal rising of triglyceride levels, exceed normal range (NR), it will hyperlipidemia occur, especially
It is that the illness rate of hyperlipidemia of the elderly is about between 30% to 50%.Hyperlipidemia is divided into primary and Secondary cases two
Kind, except minority is due to systemic disease in addition to (Secondary Hyperlipidemia), the overwhelming majority be because of genetic defect (or with
Environmental factor interacts) cause (EHL).
Hyperlipemia, easily causes " blood is thick ", deposits, gradually form little patch, i.e. atherosclerotic on vascular wall,
These " patches " increase, and increase, and gradually block blood vessel, make blood flow slack-off, and when serious, blood flow is interrupted.The clinical table of hyperlipidemia
Now mainly include two broad aspect: (1) lipid is in the xanthoma caused by intradermal deposition；(2) lipid skin in intravascular deposition institute
The atherosclerotic causing, produces coronary heart disease and peripheral angiopathy etc..
The diagnostic method of hyperlipidemia has many kinds, but at the unified diagnostic method of medical circle also neither one.Now
Predominantly detecting two indices: 1. total cholesterol density of blood plasma > 5.17mmol/L (200mg/dl) can be set to hypercholesterolemia；2.
Blood plasma triacylglycerol concentration > 2.3mmol/L (200mg/dl) is hypertriglyceridemia.
The medicine regulating blood fat density at present clinically is roughly divided into: Statins, fibrates, nicotinic acid class, resinae and courage
Sterol absorption inhibitor.Though these medicines can reduce blood fat density to a certain extent, but curative effect of medication is made by individuality with secondary
With there being very big individual difference, drug effect is unstable.Even if the disease in a period of time can be alleviated, but, although these medicines of long-term taking are also all
It is extremely difficult to the effect of radical cure, increases the weight of liver, kidney metabolism burden on the contrary, cause serious damage, and easily cause drug resistance.
Compared with western medicine, the traditional Chinese medical science has abundant medication experience and traditional Chinese medical theory basis, stresses diagnosis and treatment, nothing
Opinion is the understanding to etiology and pathogenesis or diagnoses and treatment aspect modern Chinese medicine all makes some progress, and has to reducing blood fat
More preferable curative effect.
Chinese patent application 201410637713.9 discloses a kind of blood fat-reducing heath-care wine, and the raw medicinal material of employing is respectively
It is: prepared rhizome of rehmannia 500 parts, radix rehmanniae recen 500 parts, the red sage root 450 parts, hawthorn 500 parts, the fleece-flower root 250 parts, radix cynanchi bungei 250 parts, rock sugar
1500 parts, white wine 30000 parts.This invention has lipopenicillinase embolism extinguishing, the effect reducing cholesterol, has for reducing blood lipid, norcholesterol
Positive effect.
Chinese patent application 201510591237.6 discloses a kind of blood fat reducing tea, is made up of following weight parts raw material: bitter
Melon 15-25 part, pomegranate 15-25 part, fruit of Chinese wolfberry 15-25 part, corn stigma 15-25 part, root of kudzu vine 15-25 part, preservative 0.05-0.10
Part；Described preservative is Schisantherin C and/or schizandrin.This invention blood fat reducing tea has preferable antilipemic healthy and makees
With.But this health protection tea prescription is simple, and theoretical foundation is insufficient；Processing technology is coarse, uses the mode made tea to drink, its effective one-tenth
Divide and usually destroyed because continuous high temperature soaks, or can not sufficiently be extracted because soak time is too short, quality stability
Differing from, carrying inconvenience, bioavilability is not high.
Content of the invention
For the deficiency overcoming the health food assisting reducing blood lipid in prior art to exist, by select suitable medicinal material and
Regulation compatibility, it is therefore intended that provide a kind of health food assisting reducing blood lipid, it has to invigorate blood circulation and stimulates the menstrual flow, and promoting the circulation of qi dissipates the stasis of blood, and stagnation resolvation is led to
Drench, and in inducing sweat, the effect such as clearing heat and detoxicating.This health food toxic and side effect is little, and security is high, steady quality, and easy to use.
The invention provides the health food of a kind of auxiliary reducing blood lipid containing green plum, including prepare raw material and weight thereof as follows
Number:
Green plum 18-35 part, rhizoma alismatis 10-22 part, red sage root 6-18 part, safron 8-12 part, excrementum pteropi 10-18 part, cattail pollen 2-8
Part, fleece-flower root 12-20 part, wild pseudo-ginseng 4-10 part, radix bupleuri 4-10 part, hawthorn 2-8 part, glossy ganoderma 4-10 part and Radix Glycyrrhizae 12-24 part.
In this ratio range, the more significant proportionings of preferably 3 curative effects:
Proportioning 1: 27 parts of green plum, rhizoma alismatis 16 parts, the red sage root 12 parts, safron 10 parts, excrementum pteropi 14 parts, cattail pollen 5 parts, the fleece-flower root
16 parts, wild pseudo-ginseng 7 parts, radix bupleuri 7 parts, hawthorn 5 parts, glossy ganoderma 7 parts and 18 parts of Radix Glycyrrhizae.
Proportioning 2: 18 parts of green plum, rhizoma alismatis 10 parts, the red sage root 6 parts, safron 8 parts, excrementum pteropi 10 parts, cattail pollen 2 parts, the fleece-flower root 12
Part, wild pseudo-ginseng 4 parts, radix bupleuri 4 parts, hawthorn 2 parts, glossy ganoderma 4 parts and 12 parts of Radix Glycyrrhizae.
Proportioning 3: 35 parts of green plum, rhizoma alismatis 22 parts, the red sage root 18 parts, safron 12 parts, excrementum pteropi 18 parts, cattail pollen 8 parts, the fleece-flower root
20 parts, wild pseudo-ginseng 10 parts, radix bupleuri 10 parts, hawthorn 8 parts, glossy ganoderma 10 parts and 24 parts of Radix Glycyrrhizae.
Preferably, the health food of the described auxiliary reducing blood lipid containing green plum is made into tablet, capsule, pill or oral
Liquid.
Correspondingly, the invention provides the preparation method of the health food of this auxiliary reducing blood lipid, comprise the following steps:
S1, pluck fresh green plum, dry after cleaning, add the distilled water of green plum weight 1-3 times, homogenizer stirring
10-25min, arranging mixing speed is 500-1000rpm, stands, and filters decontamination, obtains green plum slurries；
S2, the green plum slurries prepared toward S1 add ethanol solution refluxing extraction 2-4 time of 70～80%, obtains green plum extraction
Thing, standby；
S3, weigh rhizoma alismatis, the red sage root, excrementum pteropi, cattail pollen, radix bupleuri and hawthorn, grind, be ground into meal, mix, add above-mentioned
The ethanol solution of the 80-90% of meal gross weight 4-7 times, refluxing extraction 2-3 time, each 5-8 hour, merge alcohol extract, decompression
Ethanol is distilled off, obtains extract A, standby；
S4, weigh safron, the fleece-flower root, wild pseudo-ginseng, glossy ganoderma and Radix Glycyrrhizae, grind, be ground into meal, mix, add above-mentioned
The purified water of meal gross weight 8-11 times, decocts 2-3 time, each 1-3 hour, filters, merging filtrate, concentrates 1/ for original volume
6-1/4, obtains extract B, standby；
S5, described plum extract is mixed with described extract A, B, be condensed under 60-80 DEG C of environment survey relative density
Composition medicinal extract for 1.25-1.30；
S6, the composition medicinal extract prepared toward S5 add corresponding auxiliary material, according to modern Chinese herbal medicine preparation technology of preparing, preparation
Become health food finished product.
Preferably, in described step S2, solid-liquid ratio is 1:5-20.
The diagnosis and treatment of the foundation traditional Chinese medical science and the compatibility theory of Chinese medicine, in conjunction with fitness and the modern pharmaceutical skill of modern
The feature of art, the collocation ingredients of reasonable science, form health food of the present invention.Green plum convergence production of sperm, kidney calming, enhancing
Metabolism；The red sage root and safron invigorate blood circulation stimulate the menstrual flow, promoting the circulation of qi dissipates the stasis of blood, stasis-dispelling and pain-killing；Excrementum pteropi, cattail pollen and radix bupleuri Huayu Tonglin and induce sweat
In, invigorating qi for tranquilization；Glossy ganoderma, rhizoma alismatis, the fleece-flower root, wild pseudo-ginseng and hawthorn heat-clearing is convenient, removing toxicity for detumescence；Radix Glycyrrhizae appetizing and in, be in harmonious proportion
All medicines.Each component Synergistic, complements each other, and is finally reached the effects such as blood-activating and qi-promoting, treating stranguria stagnation resolvation, removing pattogenic heat from the blood and toxic material from the body, to auxiliary
Reducing blood lipid has significant effect.
Compared with prior art, the present invention has a following technical advantage:
1st, by selecting suitable medicinal material and regulation compatibility, onset of the present invention is rapid, toxic and side effect is little and has nourishing makees
With；
2nd, use the modern technologies such as refluxing extraction, decompression distillation and centrifugal spray drying, substantially effectively extract each
The active ingredient of taste medicinal material, efficacy stability, controlled；Production technology is simple and environmentally-friendly and low cost, is suitable for industrialized production.
3rd, health food of the present invention can be not only used for health care, the generation of prevention high fat of blood, can effectively alleviate again and treat height
Blood fat disease；
4th, compared with positive drug Lipitor, present composition curative effect is more notable and stable, even long-term taking is also
Damage will not be caused to the liver of human body, kidney, significantly reduce the generation of bad reaction and toxic and side effect.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following example represent the inventors discovered that at this
Bright practice plays the technology of good action.But, disclosed specific embodiments can be made many changes, and
Still same or analogous result is obtained, without departing from the spirit and scope of the present invention.
The health food of embodiment the 1st, a kind of auxiliary reducing blood lipid containing green plum
The embodiment of the present invention 1 health food is prepared from by the raw material of following parts by weight: 27 parts of green plum, rhizoma alismatis 16 parts,
The red sage root 12 parts, safron 10 parts, excrementum pteropi 14 parts, cattail pollen 5 parts, the fleece-flower root 16 parts, wild pseudo-ginseng 7 parts, radix bupleuri 7 parts, hawthorn 5 parts,
Glossy ganoderma 7 parts and 18 parts of Radix Glycyrrhizae.
Preparation method is as follows:
S1, plucking fresh green plum, drying after cleaning, add the distilled water of green plum weight 1.5 times, homogenizer stirs
10min, arranging mixing speed is 500rpm, stands, and filters decontamination, obtains green plum slurries；
S2, in green plum slurries prepared by S1 according to solid-liquid ratio be 1:13 add 80% ethanol solution, refluxing extraction 3 times,
Obtain plum extract, standby；
S3, weigh rhizoma alismatis, the red sage root, excrementum pteropi, cattail pollen, radix bupleuri and hawthorn, grind, be ground into meal, mix, add above-mentioned
The ethanol of the 85% of meal gross weight 5 times, refluxing extraction 2 times, 7 hours every time, merge alcohol extract, decompression is distilled off ethanol,
Obtain extract A, standby；
S4, weigh safron, the fleece-flower root, wild pseudo-ginseng, glossy ganoderma and Radix Glycyrrhizae, grind, be ground into meal, mix, add above-mentioned
The purified water that meal gross weight is 10 times, decocts 2 times, 2 hours every time, filters, merging filtrate, concentrate 1/5 for original volume, must carry
Take liquid B, standby；
S5, mixing described plum extract with described extract A, B, being concentrated under 70 DEG C of environment survey relative density is
The composition medicinal extract of 1.30；
S6, in composition medicinal extract prepared by S5, add corresponding auxiliary material, according to modern Chinese herbal medicine preparation technology of preparing, pressure
Piece, is prepared as tablet.
The health food of embodiment the 2nd, a kind of auxiliary reducing blood lipid containing green plum
The embodiment of the present invention 2 health food is prepared from by the raw material of following parts by weight: 18 parts of green plum, rhizoma alismatis 10 parts,
The red sage root 6 parts, safron 8 parts, excrementum pteropi 10 parts, cattail pollen 2 parts, the fleece-flower root 12 parts, wild pseudo-ginseng 4 parts, radix bupleuri 4 parts, hawthorn 2 parts, spirit
Sesame 4 parts and 12 parts of Radix Glycyrrhizae.
Preparation method is as follows:
S1, plucking fresh green plum, drying after cleaning, add the distilled water of the weight such as green plum, homogenizer stirs
15min, arranging mixing speed is 800rpm, stands, and filters decontamination, obtains green plum slurries；
S2, the green plum slurries preparing S1 are that 1:5 adds 70% ethanol solution, refluxing extraction 2 times according to solid-liquid ratio, obtain blue or green
Prunus mume extract, standby；
S3, weigh rhizoma alismatis, the red sage root, excrementum pteropi, cattail pollen, radix bupleuri and hawthorn, grind, be ground into meal, mix, add above-mentioned
The ethanol of the 80% of meal gross weight 4 times, refluxing extraction 2 times, 5 hours every time, merge alcohol extract, decompression is distilled off ethanol,
Obtain extract A, standby；
S4, weigh safron, the fleece-flower root, wild pseudo-ginseng, glossy ganoderma and Radix Glycyrrhizae, grind, be ground into meal, mix, add above-mentioned
The purified water that meal gross weight is 8 times, decocts 2 times, 1 hour every time, filters, merging filtrate, concentrate 1/6 for original volume, must carry
Take liquid B, standby；
S5, mixing described plum extract with described extract A, B, being concentrated under 66 DEG C of environment survey relative density is
The composition medicinal extract of 1.25；
S6, in composition medicinal extract prepared by S5, add corresponding auxiliary material, according to modern Chinese herbal medicine preparation technology of preparing, preparation
Piece agent.
The health food of embodiment the 3rd, a kind of auxiliary reducing blood lipid containing green plum
The embodiment of the present invention 3 health food is prepared from by the raw material of following parts by weight: 35 parts of green plum, rhizoma alismatis 22 parts,
The red sage root 18 parts, safron 12 parts, excrementum pteropi 18 parts, cattail pollen 8 parts, the fleece-flower root 20 parts, wild pseudo-ginseng 10 parts, radix bupleuri 10 parts, hawthorn 8
Part, glossy ganoderma 10 parts and 24 parts of Radix Glycyrrhizae.
Preparation method is as follows:
S1, plucking fresh green plum, drying after cleaning, add the distilled water of green plum weight 3 times, homogenizer stirs
20min, arranging mixing speed is 500rpm, stands, and filters decontamination, obtains green plum slurries；
S2, the green plum slurries preparing S1 are that 1:15 adds 90% ethanol solution, refluxing extraction 4 times according to solid-liquid ratio, obtain
Plum extract, standby；
S3, weigh rhizoma alismatis, the red sage root, excrementum pteropi, cattail pollen, radix bupleuri and hawthorn, grind, be ground into meal, mix, add above-mentioned
The ethanol of the 90% of meal gross weight 7 times, refluxing extraction 3 times, 8 hours every time, merge alcohol extract, decompression is distilled off ethanol,
Obtain extract A, standby；
S4, weigh safron, the fleece-flower root, wild pseudo-ginseng, glossy ganoderma and Radix Glycyrrhizae, grind, be ground into meal, mix, add above-mentioned
The purified water that meal gross weight is 11 times, decocts 3 times, 3 hours every time, filters, merging filtrate, concentrate 1/4 for original volume, must carry
Take liquid B, standby；
S5, mixing described plum extract with described extract A, B, being concentrated under 75 DEG C of environment survey relative density is
The composition medicinal extract of 1.30；
S6, in composition medicinal extract prepared by S5, add corresponding auxiliary material, according to modern Chinese herbal medicine preparation technology of preparing, preparation
Piece agent.
The health food of comparative example the 1st, a kind of auxiliary reducing blood lipid containing green plum
Described in comparative example 1, the health food of a kind of auxiliary reducing blood lipid containing green plum is by preparing raw material and parts by weight thereof as follows
Be prepared from: 35 parts of green plum, rhizoma alismatis 22 parts, the red sage root 18 parts, safron 12 parts, excrementum pteropi 18 parts, myrrh 8 parts, the fleece-flower root 20 parts,
Wild pseudo-ginseng 10 parts, radix bupleuri 10 parts, hawthorn 8 parts, glossy ganoderma 10 parts and 24 parts of Radix Glycyrrhizae.
Preparation method reference implementation example 3.
Comparative example 1 is with the difference of embodiment 3, and cattail pollen is replaced with myrrh.
The health food of comparative example the 2nd, a kind of auxiliary reducing blood lipid containing green plum
Described in comparative example 2, the health food of a kind of auxiliary reducing blood lipid containing green plum is by preparing raw material and parts by weight thereof as follows
Be prepared from: 35 parts of green plum, rhizoma alismatis 25 parts, the red sage root 18 parts, safron 12 parts, excrementum pteropi 18 parts, cattail pollen 8 parts, the fleece-flower root 20 parts,
Wild pseudo-ginseng 10 parts, radix bupleuri 10 parts, hawthorn 8 parts, glossy ganoderma 10 parts and 24 parts of Radix Glycyrrhizae.
Preparation method reference implementation example 1.
Comparative example 1 is with the difference of embodiment 1, adds the parts by weight of rhizoma alismatis.
The health food of comparative example the 3rd, a kind of auxiliary reducing blood lipid containing green plum
The health food of a kind of auxiliary reducing blood lipid containing green plum described in comparative example 3 prepare raw material and parts by weight thereof strictly according to the facts
Execute example 3.
The difference of its preparation method is, radix bupleuri adds in step s 4.
Test example the first, the impact on mouse effect for reducing blood fat for the health food of the present invention
1st, subjects: choose Kunming kind healthy mice 90, body weight 20g ± 3g, male and female half and half, tested by Ji'nan University
Animal center provides.Experimental animal feeding, in the environment that temperature 22～25 DEG C, humidity are 40%～70%, gives commonly to raise
Material, freely drinks water.
2nd, test material: prepared by the embodiment of the present invention the 1st, embodiment the 2nd, embodiment the 3rd, comparative example the 1st, comparative example 2 and comparative example 3
Composition tablet, add 2 times of quality water dissolve；Positive control drug be Lipitor (adopted name: atorvastatin,
Manufacturer: Pfizer Ireland Pharmaceuticals, traditional Chinese medicines quasi-word J20120050).
3rd, test packet and administration: 90 mouse are randomly divided into 9 groups, respectively blank group, model group, positive drug
Group, embodiment 1-3 group, comparative example 1-3 group, often organize each 10, and the dosage of each group is as follows:
Positive drug group: Lipitor grinds to form fine powder, is blended in distilled water, gastric infusion, dosage be equivalent to the former medicine of 10g/
Kg；
Embodiment 1-3 group: respectively the composition tablet of embodiment 1-3 group preparation is ground to form fine powder, be blended in distilled water,
Gastric infusion, dosage is equivalent to the former medicine/Kg of 30g；
Comparative example 1-3 group: respectively the composition tablet of comparative example 1-3 group preparation is ground to form fine powder, be blended in distilled water,
Gastric infusion, dosage is equivalent to the former medicine/Kg of 30g；
Blank group and model group: be not administered, the isopyknic physiological saline of gavage substitutes；
4th, test method:
First, prepare test basal feed and high lipid food, provided by Ji'nan University's Experimental Animal Center.Basal feed
Raw material forms: corn, fish meal, dregs of beans, calcium monohydrogen phosphate, flour, stone flour, yeast etc.；High lipid food formula rate be 10% lard,
1% cholesterol, cholate the 0.25%th, 88.75% basal feed.
Blank group feeding basal feed during experiment, model group and each treatment group feed high lipid food.Feed continuously
Two weeks.After modeling successfully, all mouse all change feeding basal feed, and remove food in evening every day to it, and each group presses above-mentioned dosage
Gavage gives respective amount drug therapy respectively, and blank group and model group replace with normal saline.It within 1 day, is administered once, even
Continuous 3 weeks.After 3 weeks, each group mouse equal fasting 12h, orbital vein takes blood, and under 3500r/min, centrifugal 10min separates and collects blood
Clearly, CHOD-PAP method measures T-CHOL (TC) in serum, and GPO-PAP method measures triglycerides (TG), PTA-Mg2+Method measures height
Density lipoprotein (HDL-C), PVS Precipitation Determination low-density lipoprotein (LDL-C) content.
5th, result of the test:
Table 1 result of the test
Compare with blank group,**P < 0.01,*P<0.05；Compare with model group,##P < 0.01,#P<0.05；With the positive
Medicine group compares,ΔP < 0.05,ΔΔP<0.01。
As shown in Table 1, model group mouse after 3 weeks, is compared with blank group, in serum after high lipid food feeding
TC, TG and LDL-C content increases 1.93 times, 2.32 times and 3.38 times respectively, and HDL-C reduces 1.94 times, Blood Lipid pole
For notable (P ＜ 0.01), illustrate to use the method to set up high blood lipid model success.
Positive drug Lipitor and test group medicine of the present invention all can be effectively reduced T-CHOL (TC), glycerine in Mice Body
Three esters (TG) and low-density lipoprotein (LDL-C) level, be respectively provided with significant difference compared with model group, but mouse stomach be originally
In serum after inventive embodiments 1-3 health food, TC, TG and LDL-C content is all substantially less than positive drug, and curative effect is more significantly.
It should be noted that serum high-density LP (HDL-C) is considered as a kind of antiatherogenic lipoprotein, be anti-hat
The protective factors of worry, although Lipitor has an effect of certain rising HDL-C level, but embodiment of the present invention 1-3 group and
The Serum HDL-C elevating effect of comparative example 1-3 group mouse becomes apparent from, and has statistics compared with model group and positive drug treatment group
Learn difference, wherein notable with embodiment 3 lipid-lowering effect, therefore embodiment 3 is preferred embodiment.
In 1 group of health food of comparative example, cattail pollen being replaced with myrrh, drug effect decreases compared with Example 3；Comparative example 2
Health food adds the parts by weight of rhizoma alismatis, its compared with Example 3 drug effect decrease.Current clinical treatment shows,
Take Lipitor it is possible that side effects such as digestive discomfort, headache, fash, dizziness, the dimness of vision and dysgeusias, and have report
There are insomnia, myositis, myalgia, rhabdomyolysis, hepatitis, pancreatitis and allergic reaction etc. in road, and toxic and side effect is big, exists in treatment
The defects such as curative effect is unstable, individual difference is big, treatment is not thorough.But the present composition by pure natural Chinese herbal medicine according to properly
Proportioning be prepared from, there is the unique advantage that pharmacodynamic stability is good, bioavilability is high, toxic and side effect is little.
Owing to describing the present invention by above preferred embodiment, in the spirit and/or scope of the present invention, any
The present invention is implemented in replacement/or combination for the present invention, will be apparent from for a person skilled in the art, and
It is included among the present invention.
Claims (9)
1. the health food of the auxiliary reducing blood lipid containing green plum, it is characterised in that include preparing raw material and weight portion thereof as follows
Number:
Green plum 18-35 part, rhizoma alismatis 10-22 part, red sage root 6-18 part, safron 8-12 part, excrementum pteropi 10-18 part, cattail pollen 2-8 part,
Fleece-flower root 12-20 part, wild pseudo-ginseng 4-10 part, radix bupleuri 4-10 part, hawthorn 2-8 part, glossy ganoderma 4-10 part and Radix Glycyrrhizae 12-24 part.
2. the health food of the auxiliary reducing blood lipid containing green plum as claimed in claim 1, it is characterised in that include preparing as follows former
Material and parts by weight thereof:
27 parts of green plum, rhizoma alismatis 16 parts, the red sage root 12 parts, safron 10 parts, excrementum pteropi 14 parts, cattail pollen 5 parts, the fleece-flower root 16 parts, open country three
77 parts, radix bupleuri 7 parts, hawthorn 5 parts, glossy ganoderma 7 parts and 18 parts of Radix Glycyrrhizae.
3. the health food of the auxiliary reducing blood lipid containing green plum as claimed in claim 1, it is characterised in that include preparing as follows former
Material and parts by weight thereof:
18 parts of green plum, rhizoma alismatis 10 parts, the red sage root 6 parts, safron 8 parts, excrementum pteropi 10 parts, cattail pollen 2 parts, the fleece-flower root 12 parts, wild pseudo-ginseng 4
Part, radix bupleuri 4 parts, hawthorn 2 parts, glossy ganoderma 4 parts and 12 parts of Radix Glycyrrhizae.
4. the health food of the auxiliary reducing blood lipid containing green plum as claimed in claim 1, it is characterised in that include preparing as follows former
Material and parts by weight thereof:
35 parts of green plum, rhizoma alismatis 22 parts, the red sage root 18 parts, safron 12 parts, excrementum pteropi 18 parts, cattail pollen 8 parts, the fleece-flower root 20 parts, open country three
7 10 parts, radix bupleuri 10 parts, hawthorn 8 parts, glossy ganoderma 10 parts and 24 parts of Radix Glycyrrhizae.
5. the health food of the auxiliary reducing blood lipid containing green plum as described in claim 1-4 is arbitrary, it is characterised in that described health care
Food is made into tablet, capsule, pill or oral liquid.
6. the health food of the auxiliary reducing blood lipid containing green plum as described in claim 1-4 is arbitrary, it is characterised in that described health care
Food is prepared by following steps:
S1, pluck fresh green plum, dry after cleaning, add the distilled water of green plum weight 1-3 times, homogenizer stirring 10-
25min, arranging mixing speed is 500-1000rpm, stands, and filters decontamination, obtains green plum slurries；
S2, the green plum slurries prepared toward S1 add ethanol solution refluxing extraction 2-4 time of 70～80%, obtain plum extract,
Standby；
S3, weigh rhizoma alismatis, the red sage root, excrementum pteropi, cattail pollen, radix bupleuri and hawthorn, grind, be ground into meal, mix, add above-mentioned meal
The ethanol solution of the 80-90% of gross weight 4-7 times, refluxing extraction 2-3 time, each 5-8 hour, merge alcohol extract, decompression distillation
Remove ethanol, obtain extract A, standby；
S4, weigh safron, the fleece-flower root, wild pseudo-ginseng, glossy ganoderma and Radix Glycyrrhizae, grind, be ground into meal, mix, add above-mentioned meal
The purified water of gross weight 8-11 times, decocts 2-3 time, each 1-3 hour, filters, merging filtrate, concentrates the 1/6-1/ for original volume
4, obtain extract B, standby；
S5, mixing described plum extract with described extract A, B, being condensed under 60-80 DEG C of environment survey relative density is
The composition medicinal extract of 1.25-1.30；
S6, the composition medicinal extract prepared toward S5 add corresponding auxiliary material, according to modern Chinese herbal medicine preparation technology of preparing, is prepared as protecting
Health food finished product.
7. health food as claimed in claim 6, it is characterised in that in described step S2, solid-liquid ratio is 1:5-20.
8. the preparation method of the health food of the auxiliary reducing blood lipid containing green plum as described in claim 1-7 is arbitrary, its feature exists
In comprising the following steps:
S1, pluck fresh green plum, dry after cleaning, add the distilled water of green plum weight 1-3 times, homogenizer stirring 10-
25min, arranging mixing speed is 500-1000rpm, stands, and filters decontamination, obtains green plum slurries；
S2, the green plum slurries prepared toward S1 add ethanol solution refluxing extraction 2-4 time of 70～80%, obtain plum extract,
Standby；
S3, weigh rhizoma alismatis, the red sage root, excrementum pteropi, cattail pollen, radix bupleuri and hawthorn, grind, be ground into meal, mix, add above-mentioned meal
The ethanol solution of the 80-90% of gross weight 4-7 times, refluxing extraction 2-3 time, each 5-8 hour, merge alcohol extract, decompression distillation
Remove ethanol, obtain extract A, standby；
S4, weigh safron, the fleece-flower root, wild pseudo-ginseng, glossy ganoderma and Radix Glycyrrhizae, grind, be ground into meal, mix, add above-mentioned meal
The purified water of gross weight 8-11 times, decocts 2-3 time, each 1-3 hour, filters, merging filtrate, concentrates the 1/6-1/ for original volume
4, obtain extract B, standby；
S5, mixing described plum extract with described extract A, B, being condensed under 60-80 DEG C of environment survey relative density is
The composition medicinal extract of 1.25-1.30；
S6, the composition medicinal extract prepared toward S5 add corresponding auxiliary material, according to modern Chinese herbal medicine preparation technology of preparing, is prepared as protecting
Health food finished product.
9. preparation method as claimed in claim 8, it is characterised in that in described step S2, solid-liquid ratio is 1:5-20.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610395383.6A CN106072099A (en) | 2016-06-06 | 2016-06-06 | A kind of health food of auxiliary reducing blood lipid containing green plum and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610395383.6A CN106072099A (en) | 2016-06-06 | 2016-06-06 | A kind of health food of auxiliary reducing blood lipid containing green plum and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106072099A true CN106072099A (en) | 2016-11-09 |
Family
ID=57447849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610395383.6A Pending CN106072099A (en) | 2016-06-06 | 2016-06-06 | A kind of health food of auxiliary reducing blood lipid containing green plum and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106072099A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107173806A (en) * | 2017-06-09 | 2017-09-19 | 耿成好 | A kind of health food and preparation method with blood fat reducing function |
| CN108283657A (en) * | 2018-04-18 | 2018-07-17 | 通化金汇药业股份有限公司 | A kind of production method of Roripa montana blood fat lowering capsule |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366429A (en) * | 2008-09-19 | 2009-02-18 | 王绍贤 | Smoked plum medicated health tea |
| CN101455791A (en) * | 2008-11-27 | 2009-06-17 | 朱新华 | Pure traditional Chinese medicine preparation for treating hyperlipemia |
| CN104818173A (en) * | 2014-10-08 | 2015-08-05 | 合肥丰昇园农业科技有限公司 | Hyperlipemia prevention and treatment health grape wine and production method thereof |
-
2016
- 2016-06-06 CN CN201610395383.6A patent/CN106072099A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366429A (en) * | 2008-09-19 | 2009-02-18 | 王绍贤 | Smoked plum medicated health tea |
| CN101455791A (en) * | 2008-11-27 | 2009-06-17 | 朱新华 | Pure traditional Chinese medicine preparation for treating hyperlipemia |
| CN104818173A (en) * | 2014-10-08 | 2015-08-05 | 合肥丰昇园农业科技有限公司 | Hyperlipemia prevention and treatment health grape wine and production method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 沈庆法: "高脂血症的中西医诊治", 《中国临床医生》 * |
| 黄伟素等: "青梅果产品的开发现状和发展趋势", 《食品工业科技》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107173806A (en) * | 2017-06-09 | 2017-09-19 | 耿成好 | A kind of health food and preparation method with blood fat reducing function |
| CN108283657A (en) * | 2018-04-18 | 2018-07-17 | 通化金汇药业股份有限公司 | A kind of production method of Roripa montana blood fat lowering capsule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101862367A (en) | Cassia seed soft capsule for reducing fat and losing weight and preparation method | |
| CN104857418A (en) | Spleen tonifying and appetizing medical composition and preparation method and application thereof | |
| CN103127232A (en) | Total extract for mulberry leaf prescription as well as preparation and usage thereof | |
| US20180369308A1 (en) | Chinese herbal medicine composition having a function of relieving hypothyroidism, preparation method and use thereof | |
| CN104208425B (en) | A kind of Chinese medicine preparation for being used to nurse one's health critical hypertension | |
| CN105596576A (en) | Tea bag with blood fat reducing action | |
| CN106072099A (en) | A kind of health food of auxiliary reducing blood lipid containing green plum and preparation method thereof | |
| CN104436145B (en) | It is a kind of to prevent and/or treatment allergic rhinitis and the pharmaceutical composition of allergic asthma | |
| CN104352921B (en) | Chinese medicine composition with increase bone density effect and its preparation method and application | |
| CN105267889A (en) | Traditional Chinese medicine preparation for treating hyperlipoidemia | |
| CN102462787B (en) | Chinese medicine composition for treating hypertension and improving hyperlipidemia and preparation method of Chinese medicine composition | |
| CN103479895A (en) | Heart comforting and brain clearing traditional Chinese medicine composition | |
| CN108271893A (en) | Blood fat reducing tea | |
| CN106729498A (en) | A kind of albumen powder eaten after chemicotherapy and preparation method thereof | |
| CN106942712A (en) | It is a kind of to aid in ganoderma lucidum chlorella compound health-care food of reducing blood lipid and preparation method thereof | |
| CN111643540A (en) | Eucommia ulmoides extract for treating lumbar muscle strain and preparation method thereof | |
| CN104258034A (en) | Traditional Chinese medicine composition for boosting immunity | |
| CN104510857B (en) | A kind of Chinese medicinal effective-part composition for blood fat reducing and preparation thereof | |
| CN108686126A (en) | A kind of liver-protecting and alcoholism-relieving prescription and preparation and application | |
| CN102755444A (en) | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof | |
| CN102631487B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102631486B (en) | Health care composition | |
| CN102631506B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102488810A (en) | Applications of huoxiangzhengqi soft capsule serving as medicinal preparations for treating cardiovascular and cerebrovascular diseases | |
| CN104904948A (en) | Hmong's health tea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161109 |
|
| RJ01 | Rejection of invention patent application after publication |