CN108686126A - A kind of liver-protecting and alcoholism-relieving prescription and preparation and application - Google Patents
A kind of liver-protecting and alcoholism-relieving prescription and preparation and application Download PDFInfo
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- CN108686126A CN108686126A CN201810846724.6A CN201810846724A CN108686126A CN 108686126 A CN108686126 A CN 108686126A CN 201810846724 A CN201810846724 A CN 201810846724A CN 108686126 A CN108686126 A CN 108686126A
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- Gastroenterology & Hepatology (AREA)
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- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of liver-protecting and alcoholism-relieving prescriptions, are prepared by 5~30 mass parts of miracle fruit, 5~30 mass parts of caulis bambusae in taenian, 5~30 mass parts of pueraria lobata, 5~30 mass parts of cordate houttuynia, 1~40 mass parts of hawthorn, 1~20 mass parts of Siraitia grosvenorii, 5~30 mass parts of chrysanthemum and 5~30 mass parts of cogongrass cliff berry.Raw material used in the prescription is integration of drinking and medicinal herbs, there is the prescription of formation clearing heat and detoxicating, nourishing Yin and promoting production of body fluid, Li Shui to help digestion, liver-protecting and stomach-protecting can be effectively relieved the discomforts such as alcohol intolerance, dizziness, nausea and vomiting, gasteremphraxis hydrochloric acid in gastric juice, and repair the hepatic injury caused by long-term alcohol.Liver-protecting and alcoholism-relieving formula provided by the invention is without any side effects.
Description
Technical field
The invention belongs to biomedicine technical fields, and in particular to a kind of liver-protecting and alcoholism-relieving prescription and preparation and application.
Background technology
Wine is traditional Chinese culture important component, has the effects that add to the fun pleasure, promoting blood circulation, row medicine gesture, in Chinese medicine
Health cures the disease, has critical role in social activity.E-at pleasure, drink with measure be conducive to relieve fatigue refresh oneself with anxiety, cardiac stimulant, promotion is slept.
But excessive consumption of alcohol can cause the organ damages such as digestion, nerve, cycle, respiratory system, severe patient even to cause death.World health
Tissue points out that alcoholism is the first big public hazards within the scope of the world today.In developed country, alcoholism is only second to cardiovascular disease
Disease, tumour, it has also become the third-largest public health problem.Although three sections of U.S. FDA approved naltrexone, Acamprosate and Topiramate use
In the drug for the treatment of alcoholism, however, these drug dispelling effects of alcohol differences are waited a moment, there are adverse reactions.Therefore, it is badly in need of finding high
The method of relieving the effect of alcohol of effect low toxicity alleviates public's harm caused by excessive drinking.
Unique advantages that Chinese medicine has that effect is good, rapid-action, adverse reaction is low etc. on the aspect of dispelling the effects of alcohol, alcohol dispelling food,
Health products, pharmaceutical preparations are widely used, and market prospects are boundless.There are many disintoxicating products to list at present, but these products
In the presence of having a single function, curative effect unobvious, working slowly, majority is added to the ingredients such as hormone, diuretics, excitant, is used for a long time easy
Cause hepatorenal damage.
Invention content
In view of this, the technical problem to be solved in the present invention is to provide a kind of liver-protecting and alcoholism-relieving prescription and preparation and application,
There is liver-protecting and alcoholism-relieving prescription provided by the invention clearing heat and detoxicating, nourishing Yin and promoting production of body fluid, Li Shui the multiple efficacies such as to help digestion.
The present invention provides a kind of liver-protecting and alcoholism-relieving prescriptions, by 5~30 mass parts of miracle fruit, 5~30 mass parts of caulis bambusae in taenian, pueraria lobata
5~30 mass parts, 5~30 mass parts of cordate houttuynia, 1~40 mass parts of hawthorn, 1~20 mass parts of Siraitia grosvenorii, 5~30 mass of chrysanthemum
Part and 5~30 mass parts of cogongrass cliff berry are prepared.
Preferably, by 15 mass parts of miracle fruit, 15 mass parts of caulis bambusae in taenian, 15 mass parts of pueraria lobata, 15 mass parts of cordate houttuynia, hawthorn
10 mass parts, 10 mass parts of 10 mass parts of Siraitia grosvenorii, 15 mass parts of chrysanthemum and cogongrass cliff berry.
The present invention also provides a kind of preparation methods of above-mentioned liver-protecting and alcoholism-relieving prescription, include the following steps:
A it after) impregnating miracle fruit in water, adds water to cook twice, the decocting liquid decocted twice is merged, it is dense after filtering
Contracting, obtains concentrate;
The concentrate is mixed with ethyl alcohol makes the volume content of the ethyl alcohol in concentrate be 60%, and supernatant is taken after standing
Liquid;
The supernatant concentration is removed, is dried in vacuo, is ground up, sieved, obtains mysterious fruit powder;
B the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry are mixed with water) and decocted after being impregnated
It boils twice, the decocting liquid decocted twice is merged, extracting solution is obtained;
C the mysterious fruit powder is mixed with the extracting solution), obtains mixed liquor;The proportion of the mixed liquor is 1~2;
Step A) and step B) limited without sequence.
Preferably, step A) in, the mass ratio of miracle fruit and water is 1~2 when the immersion:2~4, the soaking time
It is 6~8 hours;
Step A) in, the mass ratio for adding water to cook first time miracle fruit and water is 1~2:4~6, decocting time be 1.5~
3.0 hours, the mass ratio for adding water to cook second of miracle fruit and water was 1~2:2~4, decocting time is 1~2 hour.
Preferably, step B) in, when the immersion, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, Mao Yan
The mass ratio of the certain kind of berries and water is 1:(10~12), soaking time are 1~1.5 hour;
Step B) in, it decocts for the first time, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry and water
Mass ratio be 1:(10~12), decocting time are 1~2 hour;
Decoct second, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry and water mass ratio be
1:(8~10), decocting time are 1~2 hour.
The present invention also provides a kind of above-mentioned liver-protecting and alcoholism-relieving prescriptions in the food, health food and drug for preparing liver-protecting and alcoholism-relieving
In application.
Preferably, the food is selected from liver-protecting and alcoholism-relieving beverage.
Preferably, the dosage form of the drug is selected from oral solution, tablet, capsule or granule.
Compared with prior art, the present invention provides a kind of liver-protecting and alcoholism-relieving prescriptions, by 5~30 mass parts of miracle fruit, caulis bambusae in taenian 5
~30 mass parts, 5~30 mass parts of pueraria lobata, 5~30 mass parts of cordate houttuynia, 1~40 mass parts of hawthorn, 1~20 mass of Siraitia grosvenorii
Part, 5~30 mass parts of chrysanthemum and 5~30 mass parts of cogongrass cliff berry are prepared.Raw material used in the prescription is integration of drinking and medicinal herbs,
There is the prescription of formation clearing heat and detoxicating, nourishing Yin and promoting production of body fluid, Li Shui to help digestion, and alcohol intolerance, dizziness, evil can be effectively relieved in liver-protecting and stomach-protecting
The discomforts such as heart vomiting, gasteremphraxis hydrochloric acid in gastric juice, and repair the hepatic injury caused by long-term alcohol.Liver-protecting and alcoholism-relieving provided by the invention is formulated nothing
Any toxic side effect.
Specific implementation mode
The present invention provides a kind of liver-protecting and alcoholism-relieving prescriptions, by 5~30 mass parts of miracle fruit, 5~30 mass parts of caulis bambusae in taenian, pueraria lobata
5~30 mass parts, 5~30 mass parts of cordate houttuynia, 1~40 mass parts of hawthorn, 1~20 mass parts of Siraitia grosvenorii, 5~30 mass of chrysanthemum
Part and 5~30 mass parts of cogongrass cliff berry are prepared.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the miracle fruit that raw material includes 5~30 mass parts, preferably 10~
25 mass parts, more preferably 15~20 mass parts.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the caulis bambusae in taenian that raw material includes 5~30 mass parts, and preferably 10~25
Mass parts, more preferably 15~20 mass parts.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the pueraria lobata that raw material includes 5~30 mass parts, and preferably 10~25
Mass parts, more preferably 15~20 mass parts.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the cordate houttuynia that raw material includes 5~30 mass parts, preferably 10~
25 mass parts, more preferably 15~20 mass parts.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the hawthorn that raw material includes 1~40 mass parts, and preferably 10~30
Mass parts, more preferably 15~25 mass parts.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the Siraitia grosvenorii that raw material includes 1~20 mass parts, and preferably 5~15
Mass parts, more preferably 8~12 mass parts.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the chrysanthemum that raw material includes 5~30 mass parts, and preferably 10~25
Mass parts, more preferably 15~20 mass parts.
Liver-protecting and alcoholism-relieving prescription provided by the invention prepares the cogongrass cliff berry that raw material includes 5~30 mass parts, preferably 10~
25 mass parts, more preferably 15~20 mass parts.
In certain specific embodiments of the invention, the liver-protecting and alcoholism-relieving prescription is by 5 mass parts of miracle fruit, 5 matter of caulis bambusae in taenian
Measure part, 5 mass parts of pueraria lobata, 5 mass parts of cordate houttuynia, 10 mass parts of hawthorn, 10 mass parts of Siraitia grosvenorii, 5 mass parts of chrysanthemum, cogongrass cliff berry
5 mass parts are prepared.
In other specific implementation modes of the present invention, the liver-protecting and alcoholism-relieving prescription is by 15 mass parts of miracle fruit, caulis bambusae in taenian
15 mass parts, 15 mass parts of pueraria lobata, 15 mass parts of cordate houttuynia, 10 mass parts of hawthorn, 10 mass parts of Siraitia grosvenorii, 15 mass of chrysanthemum
Part, 10 mass parts of cogongrass cliff berry are prepared.
In other specific implementation modes of the present invention, the liver-protecting and alcoholism-relieving prescription is by 30 mass parts of miracle fruit, caulis bambusae in taenian
30 mass parts, 30 mass parts of pueraria lobata, 30 mass parts of cordate houttuynia, 20 mass parts of hawthorn, 20 mass parts of Siraitia grosvenorii, 30 mass of chrysanthemum
Part, 30 mass parts of cogongrass cliff berry are prepared.
The general flavone content of liver-protecting and alcoholism-relieving prescription provided by the invention is no less than 1.5%.
The miracle fruit used in the present invention, cures mainly and relieves the effect of alcohol, and dysphoria with smothery sensation is thirsty, vomiting, difficult urination.For relieving alcoholism after drinking,
Head clearing, the effect for tranquilizing the mind of sobering up.In inventive formulation, while having and promoting urine excretion, accelerates the works such as intestines peristalsis
With.Pueraria lobata relieves the effect of alcohol dehumidifying, promotes the production of body fluid to quench thirst, protect liver;Hawthorn stomach-invigoratinglollipop helps digestion, and cordate houttuynia, chrysanthemum, Siraitia grosvenorii are clearing heat and detoxicating, clearing profit
Larynx;Caulis bambusae in taenian promotes the production of body fluid to quench thirst, diuresis.The combination formula that relieves the effect of alcohol has liver protection, shield stomach, clearing, diuresis, promotes alcohol metabolism, protection stomach viscous
Film promotes gastrointestinal peristalsis, promotes alcohol excretion, achievees the purpose that relieve the effect of alcohol by general metabolism.There is cogongrass cliff berry clearing, liver protection to make
With.
Chinese medicine thinks that alcoholic strength is hot and gas welding, insobriety, wine poison are accumulated, and liver and spleen stomach is all dirty impaired and causes gas the moon two, controls and works as
With removing summer-heat wine poison, clearing heat and eliminating phlegm, based on supplementing qi and nourishing yin.
The present invention follows theory of traditional Chinese medical science and Theory of Composing Prescription and carries out compatibility, raw material dosage in safe range,
Each raw material coordinates compatibility, has effects that tranquilizing the mind of relieving the effect of alcohol.
The present invention also provides a kind of preparation methods of above-mentioned liver-protecting and alcoholism-relieving prescription, include the following steps:
A it after) impregnating miracle fruit in water, adds water to cook twice, the decocting liquid decocted twice is merged, it is dense after filtering
Contracting, obtains concentrate;
The concentrate is mixed with ethyl alcohol makes the volume content of the ethyl alcohol in concentrate be 60%, and supernatant is taken after standing
Liquid;
By the supernatant concentration, vacuum drying is ground up, sieved, obtains mysterious fruit powder;
B the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry are mixed with water) and decocted after being impregnated
It boils twice, the decocting liquid decocted twice is merged, extracting solution is obtained;
C the mysterious fruit powder is mixed with the extracting solution), obtains mixed liquor;The proportion of the mixed liquor is 1~2.
In the present invention, the mysterious fruit powder is prepared as follows:
It is impregnated in water after miracle fruit is cleaned first, the mass ratio of miracle fruit and water is 1~2 when the immersion:2~4,
The soaking time is 61~2:2~4 hours.
It is decocted after the completion of impregnating, in the present invention, is added water to cook twice.
The mass ratio for adding water to cook first time miracle fruit and water is 1~2:4~6, decocting time is 1.5~3.0 hours, the
After the completion of primary decoction, it is filtered, obtains decocting liquid and filter residue.
It is added water to cook into the filter residue second, the mass ratio of filter residue and water is 1~2:2~4, decocting time is 1~2
Hour, after the completion of second decocts, it is filtered, obtains decocting liquid and filter residue.
After the completion of decocting twice, the decocting liquid decocted twice (i.e. filtrate) is merged, then filters, obtains filtrate;
The filtrate is concentrated, concentrate is obtained;
The concentrate is mixed with ethyl alcohol makes the volume content of the ethyl alcohol in concentrate be 60%, and supernatant is taken after standing
Liquid;Wherein, the time of the standing is preferably 12~24 hours.
By the supernatant concentration, vacuum drying is ground up, sieved, obtains mysterious fruit powder;
Wherein, can recycle ethyl alcohol while concentration, the present invention to the method for the vacuum drying and grinding not
It is specifically limited, the known method of those skilled in the art.
In the present invention, the sieving was 40 mesh sieve, after sieving, obtained mysterious fruit powder, is placed at shady and cool drying and preserves.
In the present invention, the extracting solution of other medicinal materials in addition to miracle fruit is prepared as follows;
The caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry are mixed with water and impregnated, the leaching
When bubble, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry and water mass ratio be 1:(10~12), it is excellent
It is selected as 1:(11~12), soaking time are 1~1.5 hour.
It after immersion, decocts twice, decocts for the first time, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, Mao Yan
The mass ratio of the certain kind of berries and water is 1:(10~12), preferably 1:(11~12), decocting time are 1~2 hour;After the completion of decoction, into
Row filtering, obtains decocting liquid and filter residue;
Decoct second, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry and water be (filter residue with
Water) mass ratio be 1:(8~10), decocting time are 1~2 hour;It after the completion of decoction, is filtered, obtains decocting liquid and filter residue.
The decocting liquid decocted twice is merged, extracting solution is obtained.
The mysterious fruit powder is mixed with the extracting solution, obtains mixed liquor;The proportion of the mixed liquor is 1~2.
The present invention also provides a kind of above-mentioned liver-protecting and alcoholism-relieving prescriptions in the food, health food and drug for preparing liver-protecting and alcoholism-relieving
In application.
Wherein, the food is selected from liver-protecting and alcoholism-relieving beverage.
The dosage form of the health food and drug is selected from oral solution, tablet, capsule or granule.
There is no specifically limited, this field skills to the auxiliary material that is added in the food, health food and drug by the present invention
The acceptable auxiliary material of art personnel.
The present invention prescription that relieves the effect of alcohol has the following advantages:Alcohol intolerance, dizziness, nausea and vomiting, gasteremphraxis hydrochloric acid in gastric juice can be effectively relieved
Etc. discomforts, and repair long-term alcohol caused by hepatic injury.Speed of relieving the effect of alcohol is fast, and effect is good.Liver-protecting and alcoholism-relieving group provided by the invention
Raw material used by side belongs to medicinal and edible plant, has no adverse reaction to human body.And there is the formula that relieves the effect of alcohol of invention lipid-loweringing to make
With.Liver-protecting and alcoholism-relieving formula provided by the invention is without any side effects.
For a further understanding of the present invention, with reference to embodiment to liver-protecting and alcoholism-relieving prescription provided by the invention and prepare with
Using illustrating, protection scope of the present invention is not limited by the following examples.
Embodiment 1
Different prescriptions are with the liquor-saturated influence relieved the effect of alcohol of comparison
SPF grades of male ICR mouses 90, weight 18.4-22.0g are taken, model control group, Hai Wangjin are randomly divided by weight
Cup group,
Prescription match 1 group (5 parts of miracle fruit, 5 parts of caulis bambusae in taenian, 5 parts of pueraria lobata, 5 parts of cordate houttuynia, 10 parts of hawthorn, 10 parts of Siraitia grosvenorii,
5 parts of chrysanthemum, 5 parts of cogongrass cliff berry),
Prescription matches 2 groups of (15 parts of miracle fruit, 15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, Siraitia grosvenoriis 10
Part, 15 parts of chrysanthemum, 10 parts of cogongrass cliff berry),
Prescription matches 3 groups of (30 parts of miracle fruit, 30 parts of caulis bambusae in taenian, 30 parts of pueraria lobata, 30 parts of cordate houttuynia, 20 parts of hawthorn, Siraitia grosvenoriis 20
Part, 30 parts of chrysanthemum, 30 parts of cogongrass cliff berry),
Prescription compares 1 group of (15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, 10 parts of Siraitia grosvenorii, chrysanthemum 15
Part, 10 parts of cogongrass cliff berry);
Prescription compares 2 groups of (15 parts of miracle fruit, 15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, Siraitia grosvenoriis 10
Part, 15 parts of chrysanthemum);
Prescription compares 3 groups of (15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, 10 parts of Siraitia grosvenorii, chrysanthemums 15
Part);
Prescription compares 4 groups (15 parts of caulis bambusae in taenian, 15 parts of cordate houttuynia, 10 parts of hawthorn, 10 parts of Siraitia grosvenorii, 15 parts of chrysanthemums)
Every group 10.
After each group mouse fasting 12h, gavage prescription proportioning 1 group (6.5g crude drugs/kg), prescription match 2 groups of (13.6g respectively
Crude drug/kg), prescription proportioning 3 groups (28.6g crude drugs/kg), prescription comparison 1 group (11.7g crude drugs/kg), prescription compare 2 groups
(12.35g crude drugs/kg), prescription compare 3 groups (10.4g crude drugs/kg), prescription compares the prescription that relieves the effect of alcohol of 4 groups (8.45g crude drugs/kg)
With extra large Wang Jin cups (1.17g/kg), dosage 20ml/kg, model group gives the distilled water of same volume.After 30min, each group
Mouse is with 14mL/kg Red Star strong, colourless liquor distilled from sorghum white wine, using mouse righting reflex loss as drunk index, records righting reflex loss
Time and recovery time, calculate drunk incubation period (from gavage white wine to the time of righting reflex loss) and drunk hold time
(from righting reflex loss to recovery time).
It the results are shown in Table 1
The different prescriptions of table 1 caused with Red Star strong, colourless liquor distilled from sorghum white wine is compared mice drunk prevention effect (N=10)
Note:Compared with model group, in table 1, * P < 0.05, * * P < 0.01, each group match 1,2,3 groups with prescription+P <
0.05,++P < 0.01.
Experimental result:Compared with model control group, the time of sobering up that prescription matches 1,3 group of mouse substantially reduces, blood second
Alcohol content significantly reduces, ADH horizontal significantly raised (table 1, P < 0.05);The time of sobering up that prescription matches 2 mouse substantially reduces,
Alcohol levels in blood samples content significantly reduces, and ADH levels are without significantly raised (table 1, P < 0.01).Compared with matching 1,2,3 group with prescription, respectively
1 group of prescription comparison, 2 groups of prescription comparison, 3 groups of prescription comparison, prescription 4 groups of times of sobering up of comparison dramatically increase, alcohol levels in blood samples content
It significantly reduces, ADH levels are substantially reduced (table 1, P < 0.05).The prescription that shows to relieve the effect of alcohol matches 2 pairs of mouse and sobers up with good pre-
Anti- effect, formula and prescription of relieving the effect of alcohol 2 are (15 parts of miracle fruit, 15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, arhat
10 parts of fruit, 15 parts of chrysanthemum, 10 parts of cogongrass cliff berry) effect is optimal.
2 prescription of embodiment acts on the anti-intoxication alcohol neutralizing of mouse
2.1 relieve the effect of alcohol prescription prevention administration to Red Star strong, colourless liquor distilled from sorghum white wine cause mice drunk influence
SPF grades of male ICR mouses 50, weight 18-22g are taken, model control group, sea Wang Jin cup groups are randomly divided into
(1.17g/kg), prescription match 2 groups of (15 parts of miracle fruit, 15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, arhats
10 parts of fruit, 15 parts of chrysanthemum, 10 parts of cogongrass cliff berry) low, middle and high dose groups (5.2g crude drugs/kg, 10.4g crude drug/kg, 20.8g crude drug/
Kg), every group 10.
After each group mouse fasting 12h, gavage gives the basic, normal, high dosage of the prescription that relieves the effect of alcohol and sea Wang Jin cups (1.17g/ respectively
Kg), model group gives 0.9% sodium chloride injection of same volume.After 30min, each group mouse is with two pots of 14mL/kg Red Stars
Head white wine records the time and recovery time of righting reflex loss using mouse righting reflex loss as drunk index, calculates liquor-saturated
Wine incubation period (from gavage white wine to the time of righting reflex loss) and it is drunk hold time (from righting reflex loss to restore when
Between).It the results are shown in Table 2
Table 2. relieve the effect of alcohol prescription to Red Star strong, colourless liquor distilled from sorghum white wine cause mice drunk prevention effect (N=10)
Note:Compared with model group, * * P < 0.01.Compared with prescription matches 2 high doses,+0.01 experimental results of P <:With mould
Type control group is compared, and the drunk incubation period for 2 groups of low, middle and high dose groups mouse of prescription of relieving the effect of alcohol significantly extends, and the time of sobering up obviously contracts
Short (table 2, P < 0.01), compared with matching 3 high dose groups with prescription, prescription proportioning 2 low dosages drunk incubation period significantly reduces, and wakes up
The wine time obviously increases (P < 0.05);Prescription proportioning 2 middle dose groups drunk incubation period significantly reduces (P < 0.05).Result above
It is fitst water to show that prescription matches 2 high dose dispelling effects of alcohol.
The prescription that shows to relieve the effect of alcohol has good prevention effect to mice drunk.
2.2 relieve the effect of alcohol prescription therapeutic administration to Red Star strong, colourless liquor distilled from sorghum white wine cause mice drunk influence
SPF grades of male ICR mouses 50, weight 18-22g are taken, model group, sea Wang Jin cups group, prescription proportioning 2 are randomly divided into
Group (15 parts of miracle fruit, 15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, 10 parts of Siraitia grosvenorii, 15 parts of chrysanthemum, Mao Yan
10 parts of the certain kind of berries) low, middle and high dose groups (5.2g crude drugs/kg, 10.4g crude drug/kg, 20.8g crude drug/kg), every group 10.Each group is small
After mouse fasting 12h, after intragastric administration on mice 14ml/kg Red Star strong, colourless liquor distilled from sorghum white wine immediately gavage give the basic, normal, high dosage of the prescription that relieves the effect of alcohol and
Positive control sea Wang Jin cups (1.17g/kg), model group give the physiological saline of same volume.Made with mouse righting reflex loss
For drunk index, the time and recovery time of righting reflex loss are recorded, calculating is sobered up the time (from righting reflex loss to recovery
Time).
Table 3. relieve the effect of alcohol prescription to Red Star strong, colourless liquor distilled from sorghum white wine cause mice drunk therapeutic effect (N=10)
Note:Compared with model group, *, P < 0.05, * * P < 0.01.
Experimental result:Compared with model control group, the time of sobering up of 2 groups of low, middle and high dose groups mouse of proportioning of relieving the effect of alcohol is notable
Shorten (table 3, P < 0.05 or P < 0.01), the prescription that shows to relieve the effect of alcohol has therapeutic effect to mice drunk.
2.3 relieve the effect of alcohol influence of the prescription to mice serum concentration of alcohol and L-AD (ADH) level
SPF grades of male ICR mouses 60 are taken, Normal group, model control group, sea Wang Jin cups group, prescription are randomly divided into
Match 2 groups (15 parts of miracle fruit, 15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, 10 parts of Siraitia grosvenorii, 15 parts of chrysanthemum,
10 parts of cogongrass cliff berry) low, middle and high dose groups (5.2g crude drugs/kg, 10.4g crude drug/kg, 20.8g crude drug/kg), every group 10.
In addition to Normal group gives physiological saline, after each group mouse fasting 12h, two pots of intragastric administration on mice 14ml/kg Red Stars
Gavage gives the basic, normal, high dosage of the prescription that relieves the effect of alcohol and positive control product sea Wang Jin cups (1.17g/kg), model immediately after head white wine
Group gives the physiological saline of same volume.Administration 2.5h posterior orbits take blood, take liver.The whole blood of collection in 3000r/min from
Heart 10min takes supernatant to set -20 DEG C of refrigerators and preserves.Concentration of ethanol in serum is detected using ethyl alcohol detection kit.Mouse liver is even
It starches 3000r/min and centrifuges 15min, take supernatant, using ADH kits detection liver ADH activity.
Table 4 relieve the effect of alcohol prescription to Red Star strong, colourless liquor distilled from sorghum white wine intoxicating wine mice serum concentration of alcohol and liver ADH levels influence (N=10)
Note:Compared with Normal group,+P < 0.05,++P < 0.01.Compared with model control group, * P < 0.05, * * P <
0.01。
Experimental result:Concentration of alcohol sharply increases after mouse is drunk, 2 groups of low, middle and high dose groups serum ethyl alcohol of proportioning of relieving the effect of alcohol
Concentration significantly reduces (table 4P < 0.05 or P < 0.01).In addition, drunk mouse is also remarkably reinforced in the basic, normal, high dosage of the prescription that relieves the effect of alcohol
Liver ADH is active (P < 0.05 or P < 0.01).The prescription that shows to relieve the effect of alcohol enhances the metabolism of alcohol, reduces concentration of ethanol in serum.
Embodiment 3 is relieved the effect of alcohol influence of the prescription to volunteer's plasma ethanol concentrations
For the antialcoholism action for the prescription that confirms to relieve the effect of alcohol, we have recruited men's health volunteer and have participated in experiment, all aspirations
Person meets inclusion criteria through screening, and after signing informed consent form, subject is randomly divided into control group and prescription intervention group of relieving the effect of alcohol, often
30 people of group.All subjects participate in experiment must not drink for preceding 1 week, empty stomach fasting 4h before testing, acquisition venous blood 5ml works when experiment
For normal control, control group takes 56 degree of Red Star strong, colourless liquor distilled from sorghum white wine 100ml after physiological saline 100ml, 30min is administered at empty stomach;It relieves the effect of alcohol
Prescription intervention group empty stomach prescription matches 2 groups of (15 parts of miracle fruit, 15 parts of caulis bambusae in taenian, 15 parts of pueraria lobata, 15 parts of cordate houttuynia, 10 parts of hawthorn, sieve
10 parts of Chinese fruit, 15 parts of chrysanthemum, 10 parts of cogongrass cliff berry) 100ml, 56 degree of Red Star strong, colourless liquor distilled from sorghum white wine 100ml are taken after 30min.After drinking
30min, 60min, 120min distinguish extracting vein blood 5ml.Two groups of intersections are tested after the 7d of interval.The whole blood of acquisition is at low temperature
Blood plasma is collected by centrifugation, utilizes concentration of alcohol in chromatographic blood plasma.
This experiment uses self-controlled method, paired t-test method to be counted, and 5 is the results are shown in Table, with Normal group phase
Than the 3 time point plasma ethanol concentrations of prescription intervention group subject that relieve the effect of alcohol significantly reduce (P < 0.05), show to drink group of relieving the effect of alcohol
Fang Yinpin can reduce internal plasma ethanol concentrations.And to jingler without any dizzy, headache or nausea and vomiting symptom, and spiritual shape
State is good, does not interfere with normal work and life.
Table 5 relieve the effect of alcohol prescription to healthy volunteer's plasma ethanol influence (N=30)
Note:Compared with Normal group, * P < 0.05.
To sum up show that disintoxicating product of the invention is apparent to jingler's dispelling effects of alcohol, and has no adverse reaction.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (8)
1. a kind of liver-protecting and alcoholism-relieving prescription, which is characterized in that by 5~30 mass parts of miracle fruit, 5~30 mass parts of caulis bambusae in taenian, pueraria lobata 5~
30 mass parts, 5~30 mass parts of cordate houttuynia, 1~40 mass parts of hawthorn, 1~20 mass parts of Siraitia grosvenorii, 5~30 mass parts of chrysanthemum
It is prepared with 5~30 mass parts of cogongrass cliff berry.
2. liver-protecting and alcoholism-relieving prescription according to claim 1, which is characterized in that by 15 mass parts of miracle fruit, 15 mass of caulis bambusae in taenian
Part, 15 mass parts of pueraria lobata, 15 mass parts of cordate houttuynia, 10 mass parts of hawthorn, 10 mass parts of Siraitia grosvenorii, 15 mass parts of chrysanthemum and Mao Yan
10 mass parts of the certain kind of berries.
3. a kind of preparation method of liver-protecting and alcoholism-relieving prescription as described in claim 1~2, which is characterized in that include the following steps:
A it after) impregnating miracle fruit in water, adds water to cook twice, the decocting liquid decocted twice is merged, is concentrated after filtering,
Obtain concentrate;
The concentrate is mixed with ethyl alcohol makes the volume content of the ethyl alcohol in concentrate be 60%, and supernatant is taken after standing;
The supernatant concentration is removed, is dried in vacuo, is ground up, sieved, obtains mysterious fruit powder;
B the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry are mixed with water) and decoct two after being impregnated
It is secondary, the decocting liquid decocted twice is merged, extracting solution is obtained;
C the mysterious fruit powder is mixed with the extracting solution), obtains mixed liquor;The proportion of the mixed liquor is 1~2;
Step A) and step B) limited without sequence.
4. preparation method according to claim 3, which is characterized in that step A) in, miracle fruit and water when the immersion
Mass ratio is 1~2:2~4, the soaking time is 6~8 hours;
Step A) in, the mass ratio for adding water to cook first time miracle fruit and water is 1~2:4~6, decocting time is 1.5~3.0 small
When, the mass ratio for adding water to cook second of miracle fruit and water is 1~2:2~4, decocting time is 1~2 hour.
5. preparation method according to claim 3, which is characterized in that step B) in, when the immersion, the caulis bambusae in taenian, Pueraria lobota
Root, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry and water mass ratio be 1:(10~12), soaking time are 1~1.5 small
When;
Step B) in, decoct for the first time, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry and water matter
Amount is than being 1:(10~12), decocting time are 1~2 hour;
Decoct second, the caulis bambusae in taenian, pueraria lobata, cordate houttuynia, hawthorn, Siraitia grosvenorii, chrysanthemum, cogongrass cliff berry and water mass ratio be 1:(8
~10), decocting time is 1~2 hour.
6. a kind of liver-protecting and alcoholism-relieving prescription as described in claim 1~2 any one is in food, the health care food for preparing liver-protecting and alcoholism-relieving
Application in product and drug.
7. application according to claim 6, which is characterized in that the food is selected from liver-protecting and alcoholism-relieving beverage.
8. application according to claim 6, which is characterized in that the dosage form of the drug is selected from oral solution, tablet, capsule
Or granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114514975A (en) * | 2022-03-02 | 2022-05-20 | 高晓璐 | Bamboo shaving beverage and preparation method thereof |
| CN115715558A (en) * | 2022-11-21 | 2023-02-28 | 淮阴工学院 | Solid beverage for dispelling effects of alcohol and protecting liver and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104068175A (en) * | 2014-07-03 | 2014-10-01 | 句容茅宝葛业有限公司 | Radix puerariae and hawthorn tea and preparation method thereof |
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2018
- 2018-07-27 CN CN201810846724.6A patent/CN108686126B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104068175A (en) * | 2014-07-03 | 2014-10-01 | 句容茅宝葛业有限公司 | Radix puerariae and hawthorn tea and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 张元忠等: "土家族药茅岩莓的生药学研究", 《中国民族医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114514975A (en) * | 2022-03-02 | 2022-05-20 | 高晓璐 | Bamboo shaving beverage and preparation method thereof |
| CN115715558A (en) * | 2022-11-21 | 2023-02-28 | 淮阴工学院 | Solid beverage for dispelling effects of alcohol and protecting liver and preparation method thereof |
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| CN108686126B (en) | 2021-04-23 |
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