CN103127232A - Total extract for mulberry leaf prescription as well as preparation and usage thereof - Google Patents
Total extract for mulberry leaf prescription as well as preparation and usage thereof Download PDFInfo
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Abstract
The invention provides a total extract for a mulberry leaf prescription as well as preparation and usage thereof. The total extract for the mulberry leaf prescription mainly comprises 5%-95% of polysaccharide, 1%-90% of saponin, 1%-90% of flavonoid, 1%-90% of volatile oil and 1%-90% of alkaloid. On the basis of inheritance of traditional Chinese medicine essence, active ingredients for the prescription are extracted by the inventor according to the modern science and technology for preparing the conventional preparation convenient for patients to take. Lipid reduction, depressurization, blood glucose reduction, immune adjustment, liver injury and tumor resistance experiments on animals prove that the tested medicine has multiple pharmacological activities such as lipid reduction, depressurization, blood glucose reduction, immune adjustment, anti-atherogenic ability, liver protection, tumor resistance and the like and does not show an obvious toxic and side effect.
Description
Technical field
The invention belongs to Chinese medicine and health product technology field; particularly; the present invention relates to a kind of take old docter of TCM Mr. Zhang Renji clinical experience as the basis; possess the effects such as blood pressure lowering, blood sugar lowering, blood fat reducing, raising immunity, antitumor, blood circulation promoting and blood stasis dispelling, liver injury protection; be used for the treatment of diabetes, hyperlipemia, hypertension, arteriosclerosis, tumor and insomnia, coronary heart disease, hepatopathy, antiinflammatory antiviral, the traditional Chinese compound medicine of the diseases such as arthritis and Chinese medicine health care product extract and preparation method thereof and preparation.
Background technology
Folium Mori side comes from Zhang Renji chief physician clinical experience use side, Zhang Lao is born in 1915, successively attend Medical School of Peking University, North China state medical college, Japanese health ministry medicine private school, and visit famous traditional Chinese medical science Mr. Shi Jinmo and examine for many years for the teacher waits upon, be engaged in for a long time tcm clinical more than 50 years, clinical interior, youngster, tumor, the gynecological of being good at.Pathogenesis for heat in blood, the deficiency of vital energy, the blood stasis three large causes of disease in commonly encountered diseases sums up clearing away heat and promoting production of body fluid, three cards of the Channel Group that tonifies Qi of the kidney, invigorates blood circulation control principle, abide by the method for executing old medication in conjunction with long-term clinical practice, forms Folium Mori side and applies to face the disease treatment.Folium Mori side is comprised of Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori etc. four flavor common Chinese medicines, Folium Mori wind and heat dispersing wherein, liver heat removing and eyesight improving; The Ramulus Mori wind-damp dispelling, sharp joint, row aqueous vapor; The Cortex Mori eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema; The Fructus Mori YIN nourishing of enriching blood, promote the production of body fluid and moisturize, four medicines are favourable in share clearly, benefit is arranged, both eliminating damp-heat, blood-activating and qi-promoting in logical, again can the kidney tonifying Yin-nourishing and body fluid promoting moisturize, deficiency and excess takes into account, bring out the best in each other, suit pathogenesis, be usually used in treating multiple chronic disease and the Senile disease treatments such as diabetes, hyperlipemia, hypertension, arteriosclerosis, tumor recovering, arthritis in clinical.The inventor has carried out more going deep into scientific research and excavation to this prescription on the basis of inheriting tradition Chinese medicine elite, after the further science of we is extracted, carried out following correlation test: large mice blood fat reducing, blood pressure lowering, blood sugar lowering test; To the anxious poison test of long term toxication, rat and the mice of animal immune adjusting test, hepatic injury test, antitumor test and rat etc.Prompting Folium Mori side does not show obvious toxicity reaction in trial dosage range, and has the multiple efficacies such as obvious blood fat reducing, blood pressure lowering, blood sugar lowering, liver injury protection, raising immunity of organisms, antitumor., be used for the treatment of diabetes, hyperlipemia, hypertension, arteriosclerosis, tumor and insomnia, coronary heart disease, hepatopathy, antiinflammatory antiviral, the multiple chronic disease such as arthritis and Senile disease treatment.Simultaneously, find that not yet identical and similar product is arranged on market.
Summary of the invention
The present invention is directed to above-mentioned disease, a kind of effective prescription combination is provided, formed by the four flavor Chinese medicines such as Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori.
The present invention is directed to this prescription combination, further the patient can be cured timely its extraction, remove the fatigue that boils decoction from, the decoction that its curative effect of while boils higher than Chinese medicine prescription commonsense method.
The present invention also provides the preparation method of this total extract.
It mainly contains the 5%-95% polysaccharide Folium Mori side's total extract, 1%-90% Saponin, 1%-90% flavonoid and 1%-90% volatile oil.
Total extract its Chinese crude drug in Folium Mori side's can adopt following concocting method: processed with wine, vinegar system, processed with salt, processed with Rhizoma Zingiberis Recens, parch, calcine or make Folium Camelliae sinensis.
The preparation method of Folium Mori side's total extract, after it is characterized in that Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori pulverizing, preparations shaping gets final product, wherein Folium Mori also can steam green grass or young crops, drying adds separately after making Folium Camelliae sinensis, add after also the Folium Mori of prescription middle part component can being made Folium Camelliae sinensis.
The preparation method of Folium Mori side's total extract, it is characterized in that concentrate drying gets final product after Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori are with solvent extraction, wherein Folium Mori also can steam green grass or young crops, drying adds separately after making Folium Camelliae sinensis, add after also the Folium Mori of prescription middle part component can being made Folium Camelliae sinensis
The preparation method of Folium Mori side's total extract is characterized in that after Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori are with solvent extraction concentrated centrifugally, and after macroporous resin bed solvent elution, concentrate drying gets final product
The preparation method of compound mulberry leaf side's total extract is characterized in that Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori are placed in supercritical CO
2In abstraction instrument, add solvent extraction.
Described resin is D-101 type adsorbent resin, XAD-2 type adsorbent resin, CHP-20P type adsorbent resin, SP825 type adsorbent resin or HP-20 type adsorbent resin.
The weight fraction ratio of described Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori is 1 part-5 parts: 1 part-3 parts: 1 part-5 parts: 1 part-5 parts.
Described solvent is the one or more combination in water, methanol, ethanol, n-butyl alcohol, acetone.
Described extraction can be adopted one of following method or its combination: medical material micronizing, solvent extraction method, resin adsorption method, supercritical extraction.
Described total extract, in wherein said solvent extraction method, described extraction is at room temperature to infiltrate extraction, perhaps infiltrates under heated condition and extracts or reflux, extract,, extraction time can be once can be repeatedly also.
Above-mentioned Folium Mori side total extract can with the auxiliary preparation that is made into of pharmaceutically acceptable carrier.
The dosage form of described preparation is medicinal tea, beverage, oral liquid, tablet, drop pill or capsule.
Described extract can apply to it to treat diabetes, hyperlipemia, hypertension, arteriosclerosis, tumor and insomnia, coronary heart disease, hepatopathy, antiinflammatory antiviral, the application in the multiple chronic disease of arthritis etc. and Senile disease medicine in preparation treatment treatment.
The inventor is on the basis of inheriting tradition Chinese medicine elite, and using modern science and technology to extract the components such as effective ingredient in this prescription such as polysaccharide, Saponin, flavone becomes the modern Chinese medicine product with its exploitation.
The invention provides three kinds of methods that obtain extract of the present invention.Method one: after Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori are pulverized, preparations shaping get final product, and wherein Folium Mori also can steam green grass or young crops, drying adds separately after making Folium Camelliae sinensis, adds after also the Folium Mori of component in the middle part of prescription can being made Folium Camelliae sinensis.Method two: with Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori with solvent extraction after concentrate drying get final product, wherein Folium Mori also can steam green grass or young crops, drying adds separately after making Folium Camelliae sinensis, add after also the Folium Mori of prescription middle part component can being made Folium Camelliae sinensis.Method three: Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori are concentrated centrifugal after with solvent extraction, and after macroporous resin bed solvent elution, concentrate drying gets final product.By absorption and the solvent elution of macroporous resin bed, the composition of major part without drug effect is adsorbed on resin, simultaneously above-mentioned active component is got off by solvent elution, makes that in extract, active ingredient has obtained purification.Method four: Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori are placed in supercritical CO
2In abstraction instrument, add solvent extraction.resin separation purification technology and supercritical extraction technique in extraction process of the present invention, all one of crucial isolation technics of the modernization of Chinese medicine, its technology and equipment is advanced practical, enrichment the prescription in effective component group, can improve drug action, medical material utilization rate and reducing production costs, Chinese medicine is made the modernization dosage form that meets international standard, be conducive to also simultaneously that in the other side, each medicine carries out clear and definite quantitative analysis, improve quality standard standby, can make the tradition prescription carry out further clinical application research such as the release of oral administration intestinal specificity controlled release drug, specific part begins degraded in vivo, discharge, guaranteed absorption strength, the medicine of protecting some easily to degrade under one's belt and losing efficacy, double-absorption hydrolyzate etc., dose will be reduced to about 3 grams every day in addition, broken through the large and thick tradition image of Chinese medicine, easy to patients, the rhythm that meets the modern life, reduce patient's gastrointestinal drug absorption metabolism burden.Can see that thus the present invention has selected the Advantages of TCM field, the modernization standard that possesses old prescription, new technology, new adjuvant, new equipment, effective ingredient is clear, effect is clear and definite, without obvious toxic-side effects, meet Chinese medicine modernization development in science and technology thinking and modernization of Chinese medicine industrial development direction, have very strong clinical value and exploitation future.
Extract of the present invention is found animal blood fat reducing, blood pressure lowering, blood sugar lowering, immunomodulating, hepatic injury, antitumor test; this tested medicine has the multiple pharmacologically active effects such as obvious blood fat reducing, blood pressure lowering, blood sugar lowering, immunomodulating, arteriosclerosis, liver protection, antitumor; and without obvious toxic-side effects
The specific embodiment
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for explanation the present invention rather than limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent in the present invention is percetage by weight.
The preparation of embodiment 1 Folium Mori side's total extract (1)
With Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori medical material or decoction pieces or concoct decoction pieces and pulverize that (four ratio is 1.5: 1: 1.5: 1.5), cross 20 mesh sieves, put and pulverize to get extract in super micron mill.
Smashing fineness: 50-200 order
Centrifugal condition: centrifugal rotational speed 2000-30000rpm
Experimental result: sample yield 85-95%
The preparation of embodiment 2 Folium Mori side's total extracts (2)
With Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori medical material or decoction pieces or concoct decoction pieces and pulverize that (four ratio is 1: 1: 1: 1), cross 20 mesh sieves, put and add water extraction in extraction pot, the concentrated centrifugal drying of extracting solution is got extract.
Extraction conditions: water consumption 3-15 is doubly to the medical material amount, and extraction time 1-3 hour, extraction time 1-4 time.
Concentrated condition: be concentrated into relative density 0.9-1.3
Centrifugal condition: centrifugal rotational speed 3000-30000rpm, centrifugation time 15-45min
Experimental result: sample yield 15-25%
The preparation of embodiment 3 Folium Mori side's total extracts (3)
With Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori medical material or decoction pieces or concoct decoction pieces and pulverize that (four ratio is 1: 0.5: 2: 2), cross 20 mesh sieves, put and add water extraction in extraction pot, the concentrated centrifugal drying of extracting solution is got extract.Separately get Folium Mori (ratio 0.5) steaming and fry into tea, mixing adds in above extract.
Extraction conditions: water consumption 3-15 is doubly to the medical material amount, and extraction time 1-3 hour, extraction time 1-4 time.
Concentrated condition: be concentrated into relative density 0.9-1.3
Centrifugal condition: centrifugal rotational speed 3000-30000rpm, centrifugation time 15-45min
Experimental result: sample yield 15-25%
The preparation of embodiment 4 Folium Mori side's total extracts (4)
With Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori medical material or decoction pieces or concoct decoction pieces and pulverize that (four ratio is 1: 1: 2: 2), cross 20 mesh sieves, put and add ethanol extraction in extraction pot, extracting solution is concentrated centrifugal, after crossing the macropore resin bed, ethanol elution reclaims, the dry extract that gets.
Extraction conditions: concentration of alcohol 15-80%, ethanol consumption 3-15 be doubly to the medical material amount, and extraction time 1-3 hour, extraction time 1-4 time.
Concentrated condition: be concentrated into relative density 0.9-1.3
Centrifugal condition: centrifugal rotational speed 3000-30000rpm, centrifugation time 15-45min
Elution requirement: eluent concentration of alcohol 10-90%, eluent consumption 3-15 are doubly to medical material amount recovering condition: reclaim relative density 1.0-1.4
Experimental result: sample yield 5-10%.
The preparation of embodiment 5 Folium Mori side's total extracts (5)
With Folium Mori, Ramulus Mori, Cortex Mori, Fructus Mori medical material or decoction pieces or concoct decoction pieces and pulverize that (four ratio is 2: 1: 2: 3), cross 20 mesh sieves, put supercritical CO
2Add alcohol extraction in abstraction instrument;
Extraction conditions: pressure: 35Mpa, temperature: 45 ℃ (± 3 ℃);
Separation condition: the first separating still separation condition: pressure: 10Mpa, temperature: 45 ℃ of left and right;
The second separating still condition: pressure: 5Mpa, temperature: 40 ℃ (± 3 ℃);
Collect the second extraction kettle extract, sucking filtration, centrifugal, get oil reservoir and namely get total extract (3).
Experimental result: sample yield 3-10%.
The preparation of embodiment 6 Folium Mori side's total extract tablets
Get Folium Mori side's total extract total extract, mix pressurization with adjuvants such as lactose, magnesium stearate, microcrystalline Cellulose in flakes, put into coating pan and add the coating solution coating.Nearly air temperature: 40 ℃, atomizing pressure: 3.5Kg, sheet bed tempertaure: 35 ℃, rotating speed: 4-10 minute, tablet weightening finish: 8%.Result shows: the smooth exquisiteness of tablet appearance, hide fully, and disintegrate is up to specification.
The preparation of embodiment 7 Folium Mori side's total extract drop pill
Get Folium Mori side's total extract, with adjuvant heating and meltings such as Polyethylene Glycol, mixed proportion stirs, in the impouring pill dripping machine, splash under 80 ℃ of constant temperature in 5 ℃ of dimethyl-silicon wet goods condensed fluid, drip 35 droplets/minute of speed, drip apart from 5cm, leach drop pill, clean condensed fluid, packing is made drop pill and be get final product.
Result shows: drop pill rounding, industrial easy to operate, physical and chemical index is qualified.
The preparation of embodiment 8 Folium Mori side's total extract soft capsules
Take in proportion in the putting glue tanks such as gelatin, glycerol, water, 40-80 ℃ of water-bath glue after being molten state, adds the opacifiers such as titanium dioxide, the toners such as cacao brown under stirring.To be mixed evenly after, the evacuation bubble removing.Glue and the Folium Mori side's total extract handled well are added respectively in capsule machine glue bucket and hopper compacting.Soft gelatin capsule was put to the high and dry chamber dry 24 hours, got qualified soft gelatin capsule and get final product.
The preparation of embodiment 9 Folium Mori side's total extract teabag
Get the adjuvant mixing granulations such as Folium Mori side's total extract and lactose, magnesium stearate, microcrystalline Cellulose, and get Folium Mori (ratio 0.5) steaming and fry into tea, put into the pack of teabag processing machine after mixing and get final product.
The regulating action of embodiment 10. Folium Mori side's total extracts to immune function of mice
The following table result of the test shows, in to mouse spleen lymphocyte conversion test and Peritoneal Macrophage Phagocytosis test, Folium Mori side's total extract can obviously improve the multiplication capacity of T, bone-marrow-derived lymphocyte and improve Phagocytosis By The Peritoneal Macrophages In Mice, but the immunologic function of the tested medicine enhancing body of this conclusion prompting, its action pathway that improves immunity may be by improving cellular immune function and the macrophage phagocytic function of body.
The impact that table 1 this product is bred mouse lymphocyte (X ± SD)
Annotate: compare * P＜0.05 with matched group, as follows.
Table 2 this product is on the impact of Phagocytosis By The Peritoneal Macrophages In Mice (X ± SD)
The blood sugar reducing function of embodiment 10. Folium Mori side's total extracts to the hyperglycemia model mice
The demonstration of following table result of the test, in the modeling of streptozotocin lumbar injection was formed the test of pesticide effectiveness of zoic model with hyperglycemia, Folium Mori side's total extract can obviously reduce the blood sugar level of animal pattern, and prompting this product has certain effect of lowering blood sugar.
Table 1 this product is to the blood sugar reducing function to the hyperglycemia model mice
The impact test of embodiment 11. Folium Mori side's total extracts on the mouse carbon tetrachloride acute liver damage
The demonstration of following table result of the test, Folium Mori side's total extract can significantly reduce animal pattern serum alt, AST value, and its hepatic pathology changes and also obviously alleviates, and shows that tested medicine has obvious protective effect to the hepatic injury of body.
The influence of table 1 this product to mice serum ALT, AST
The impact test of embodiment 12. Folium Mori side's total extracts on spontaneous hypertensive rat (SHR) blood pressure
The demonstration of following table result of the test, Folium Mori side's total extract can significantly reduce animal pattern systolic pressure value, shows that tested medicine has certain hypotensive effect.
The influence of table 1 this product to the rat model systolic pressure
The impact test of embodiment 13. Folium Mori side's total extracts on hyperlipemia rat (feedstuff method) blood fat
The demonstration of following table result of the test, Folium Mori side's total extract can significantly reduce cholesterol, triglyceride, the low density lipoprotein, LDL value of animal pattern, shows that tested medicine has certain effect for reducing blood fat.
The influence of table 1 this product to hyperlipemia rat TC
The influence of table 2 this product to hyperlipemia rat TG
The influence of table 3 this product to hyperlipemia rat LDL
The antitumor impact test of embodiment 14. Folium Mori side's total extracts on the solid tumor tumor animal
The demonstration of following table result of the test, Folium Mori side's total extract has obvious tumor-inhibiting action, shows that tested medicine may have certain antitumor action.
The influence of table 1 this product to tumor-bearing mice
Claims (10)
1. the prescription of a total extract, it is characterized in that: extract take Folium Mori, Ramulus Mori, Cortex Mori, four kinds of Chinese crude drugs of Fructus Mori or its process of preparing Chinese medicine decoction pieces the active component that obtains as raw material, four kinds of medical materials are that ratio is Folium Mori 10-80%, Ramulus Mori 10-80%, Cortex Mori 5-70%, Fructus Mori 5-70%, wherein, the higher limit of a certain component adds other component lower limit≤100%.
2. total extract claimed in claim 1, its component of extract and weight ratio are the 5-95% polysaccharide, 1-90% Saponin class, the 1-90% flavonoid, 1-90% volatile oil, and 1-90% alkaloids, wherein, the higher limit of a certain component adds other component lower limit≤100%.
3. total extract claimed in claim 1, wherein said medical material can adopt following concocting method: processed with wine, vinegar system, processed with salt, processed with Rhizoma Zingiberis Recens, parch, calcine or make Folium Camelliae sinensis.
4. the described total extract of claim 1, wherein said extraction can be adopted one of following method or its combination: medical material micronizing, solvent extraction method, resin adsorption method, supercritical extraction.
5. the described total extract of claim 4, in wherein said solvent extraction method, a kind of in the optional water of described solvent, ethanol, also above two kinds of optional use is mixed with arbitrary proportion.
6. the described total extract of claim 4, in wherein said solvent extraction method, described extraction is at room temperature to infiltrate extraction, perhaps infiltrates under heated condition and extracts or reflux, extract,, extraction time can be once can be repeatedly also.
7. the described total extract of claim 4, in wherein said resin adsorption method, resin can be selected the adsorbent resin of D-101 type adsorbent resin, XAD-2 type adsorbent resin or CHP-20P type adsorbent resin, SP825 type adsorbent resin, HP-20 type adsorbent resin and other types, one or more in eluting solvent water, methanol, ethanol, acetone, aqueous methanol, aquiferous ethanol or aqueous acetone, can the concentration eluting during eluting, also can gradient elution.
8. the described total extract of claim 4, in wherein said supercritical extraction, supercritical CO
2Extraction conditions is pressure: 5-35Mpa, temperature: room temperature 30-60 ℃ of extract separation condition.
9. the pharmaceutical dosage form of total extract claimed in claim 1, can be the interior dosage form of using of oral administration, comprising: syrup, powder, pill, medicinal tea, oral liquid, beverage, capsule, granule, tablet, drop pill, enteric coated capsule, enteric coated tablet, pellet, microcapsule, effervescent, disintegrating agent, film coating tablet, sugar coated tablet or sustained-release and controlled release dosage form.
10. the application of total extract claimed in claim 1 in the medicine of the following disease of preparation treatment, described disease is: be used for the treatment of diabetes, hyperlipemia, hypertension, arteriosclerosis, tumor and insomnia, coronary heart disease, hepatopathy, antiinflammatory antiviral, the purposes in the multiple chronic disease such as arthritis and Senile disease treatment.
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| CN104256408A (en) * | 2014-07-25 | 2015-01-07 | 宁国市瑞龙生态农林开发有限公司 | Process for extracting traditional Chinese medicine components of mulberries |
| CN105559074A (en) * | 2016-02-03 | 2016-05-11 | 华南农业大学 | Application of tea volatile essential oil to preparation of anti-cancer health care product or anti-cancer drug |
| CN106560080A (en) * | 2015-09-30 | 2017-04-12 | 刘小会 | Health food for preventing and treating hepatic fibrosis of hepatitis B patients, and preparation process thereof |
| CN107206040A (en) * | 2014-06-16 | 2017-09-26 | 尤尼根公司 | For managing or improving bone disorders, cartilage disorder or combination thing and method |
| CN109181878A (en) * | 2018-09-29 | 2019-01-11 | 广州岐灵生物医药有限公司 | A kind of plants essential oil production method |
| CN109223865A (en) * | 2018-11-07 | 2019-01-18 | 西南大学 | A kind of preparation method of Folium Mori alkaloid and the application for the Folium Mori alkaloid being prepared |
| CN111000898A (en) * | 2013-06-17 | 2020-04-14 | 尤妮金公司 | Compositions and methods for joint health |
| CN113694198A (en) * | 2020-05-23 | 2021-11-26 | 陈燕 | A preparation and method for extracting antiviral components from plants and Chinese medicinal materials |
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| CN111000898A (en) * | 2013-06-17 | 2020-04-14 | 尤妮金公司 | Compositions and methods for joint health |
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| CN106560080A (en) * | 2015-09-30 | 2017-04-12 | 刘小会 | Health food for preventing and treating hepatic fibrosis of hepatitis B patients, and preparation process thereof |
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| CN109181878A (en) * | 2018-09-29 | 2019-01-11 | 广州岐灵生物医药有限公司 | A kind of plants essential oil production method |
| CN109223865A (en) * | 2018-11-07 | 2019-01-18 | 西南大学 | A kind of preparation method of Folium Mori alkaloid and the application for the Folium Mori alkaloid being prepared |
| CN109223865B (en) * | 2018-11-07 | 2021-05-07 | 西南大学 | Preparation method of mulberry leaf alkaloid and application of prepared mulberry leaf alkaloid |
| CN113694198A (en) * | 2020-05-23 | 2021-11-26 | 陈燕 | A preparation and method for extracting antiviral components from plants and Chinese medicinal materials |
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Application publication date: 20130605 |