CN1840162B - Compound total extract of compound cape jasmine, ginger and fermented soybean, its preparation and use - Google Patents
Compound total extract of compound cape jasmine, ginger and fermented soybean, its preparation and use Download PDFInfo
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- CN1840162B CN1840162B CN2006100112498A CN200610011249A CN1840162B CN 1840162 B CN1840162 B CN 1840162B CN 2006100112498 A CN2006100112498 A CN 2006100112498A CN 200610011249 A CN200610011249 A CN 200610011249A CN 1840162 B CN1840162 B CN 1840162B
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Abstract
The invention provides a compound extract for tranquillization, infantile eclampsia resistance and digestion promotion, which comprises 5-95% of iridoid glycosides, 1-90% of saponins, 1-90% of terpenes, 1-90% of flavones and 1-90% of volatile oil.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly, the present invention relates to compound total extract of compound cape jasmine, ginger and fermented soybean and its preparation thereof.
Background technology
Cape jasmine, ginger and fermented soybean soup is made up of Fructus Gardeniae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens, be one of basic side of treatise on Febrile Diseases syndrome of decoction ZHI ZI (Fructus gardeniae) CHI (Semen sojae preparatum) class, increased Rhizoma Zingiberis Recens simply with respect to the main formula Decoction of Capejasmine and Fermented Soybean, prescription Fructus Gardeniae hardship with pathogenic fire purging, coldly loose with heat clearing away and hot sweet a surname of fragrant fermented soya beans, salted or other wise, expelling pathogenic factors from the exterior and increased the cold expelling that induces sweat, the warming middle-JIAO to arrest vomiting of Rhizoma Zingiberis Recens, the effect of preventing phlegm from forming and stopping coughing on the function basis that goes out, make its function cure mainly from the expelling pathogenic factors from the exterior of the Decoction of Capejasmine and Fermented Soybean expel the heat-evil, removing stagnation to relieve restlessness, transfer clearing away the stagnated heat, stomach function regulating preventing or arresting vomiting to, effects such as calm, analgesic, antiinflammatory, blood pressure lowering, infection, antifungal have been arranged.Modern study shows in this prescription that its main pharmacodynamics composition has become through people's extensive studies and confirms to have multiple bioactive material, show 1. effect to liver as iridoid glycosides pharmacological research in the Fructus Gardeniae: the function of gallbladder promoting hepatoprotective increases enzyme activity and bile secretion, increase Y albumen, the Z protein content, promote pancreatic secretion 2. to the gastrointestinal effect: the gastric acid inhibitory secretion, the two-ways regulation gastrointestinal motility is 3. to cardiovascular effect: reduce myocardial contraction, bring high blood pressure down, prevent that atherosclerosis is 4. to central nervous system's effect: tranquilizing soporific, antipyretic-antalgic be antiinflammatory action and to the effect of pathogenic microorganism 5..Be usually used in diseases such as hepatitis, coronary heart disease, gastropathy are hemorrhage, psychosis, antiinflammatory antiviral in clinical; One-tenth such as the Saponin in the Semen Sojae Preparatum, isoflavone, polypeptide are grouped into, pharmacological research shows 1. functions of lowering blood-fat and reducing weight, and the prevention of hyperlipemia is reduced 2. anticoagulation. antithrombotic and antidiabetic effect be 4. 5. mutation and antitumaous effect of immunoregulation effect of antioxidation and antivirus action 3.; Zingiberone in the Rhizoma Zingiberis Recens; gingerol; zingiberene; compositions such as gingerol; 1. pharmacological research shows the effect to liver: the hepatocyte of function of gallbladder promoting hepatoprotective reparation damage is 2. to the gastrointestinal effect: anti-alimentary tract ulcer; promote gastrointestinal motility; the protection mucomembranous cell; preventing or arresting vomiting is told 3. to cardiovascular effect: the heart tonifying blood pressure lowering; suppress vasoconstriction; blood fat reducing; prevent that atherosclerosis is 4. to immune effect: can improve body nonspecific immunity function; specific immune function there is dual regulation; the activity level that can improve natural killer cell 5. antiinflammatory action 6. to central nervous system's effect: have calmness; analgesic; analgesia and the 7. effect of resisting pathogenic microbes of anticonvulsant action: antibacterial; the protozoacide effect is 8. to the respiratory system effect: analgesic; unimpeded respiratory tract, relieving cough and resolving phlegm, excited respiratory center is antitumor action etc. 9..Be usually used in diseases such as digestive system disease, cardiovascular disease, psychosis, antiinflammatory antiviral, antitumor such as gastrointestinal in clinical.But yet there are no the Chinese patent medicine of cape jasmine, ginger and fermented soybean now on the market.
Summary of the invention
The present invention is directed to the blank in the said goods field, a kind of cape jasmine, ginger and fermented soybean total extract and preparation thereof are provided, the patient can be cured timely, remove the fatigue that boils decoction from, its curative effect is higher than the decoction that Chinese medicine prescription commonsense method boils simultaneously.
The present invention also provides the preparation method of this total extract.
Compound total extract of compound cape jasmine, ginger and fermented soybean, it mainly contains the 5%-95% iridoid glycosides, 1%-90% Saponin, 1%-90% terpenoid, 1%-90% flavonoid and 1%-90% volatile oil.
Described iridoid glycoside apoplexy due to endogenous wind contains the 10%-95% gardenoside, mainly is soyasaponins in the Saponin, mainly is (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone in the terpenoid, mainly is soybean isoflavone in the flavonoid, mainly is gingerol and zingiberene in the volatile oil.
Wherein gardenoside content is 10%-20%, and soybean isoflavone is 2%-10%, and gingerol is 1%-8%.
The preparation method of compound total extract of compound cape jasmine, ginger and fermented soybean is characterized in that concentrating after Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens are with solvent extraction centrifugal, and after macroporous resin bed solvent elution, concentrate drying gets final product.Described solvent is the one or more combination in water, methanol, ethanol, n-butyl alcohol, the acetone.
The preparation method of compound total extract of compound cape jasmine, ginger and fermented soybean is characterized in that Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens place supercritical CO
2In the abstraction instrument, adopt resin adsorption method, add solvent extraction.
Described resin is a D-101 type adsorbent resin, XAD-2 type adsorbent resin, CHP-20P type adsorbent resin, SP825 type adsorbent resin or HP-20 type adsorbent resin.
The weight fraction ratio of described Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens is 1 part-5 parts: 1 part-3 parts: 1 part-5 parts.
Above-mentioned compound recipe cape jasmine, ginger and fermented soybean extract can be assisted with pharmaceutically acceptable carrier and is made into preparation.
The dosage form of described preparation is tablet, drop pill or capsule.
The application of described extract in the medicine of preparation treatment neurosis, upper respiratory tract infection, acute or chronic gastritis and insomnia.
The inventor is on the basis of inheriting tradition Chinese medicine elite, the utilization modern science and technology are extracted the effective ingredient in this prescription, as the iridoid glycosides in the Fructus Gardeniae, Saponin in the Semen Sojae Preparatum, soybean isoflavone, polypeptide etc., component such as volatile oil, terpenoid becomes the modern Chinese medicine product with its exploitation in the Rhizoma Zingiberis Recens.
The total extract that the inventive method obtains is a raw material with Fructus Gardeniae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens, with iridoid glycoside constituents, Saponin constituents, ter penoids, flavonoid and volatile oil component is main active, wherein the iridoid glycosides component content can reach 5-95%, and wherein gardenoside content is 10-95% in the iridoid glycoside constituents; The Saponin constituents can reach 1-90%, and wherein the Saponin constituents comprises soyasaponins etc.; Ter penoids can reach 1-90%, and wherein ter penoids comprises (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone etc.; Flavones ingredient can reach 1-90%, and wherein flavones ingredient comprises soybean isoflavone etc.; The volatile oil composition can reach 1-90%, comprising compositions such as gingerol, zingiberenes.
The invention provides two kinds of methods that obtain extract of the present invention.Method one: Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens concentrate after with solvent extraction centrifugal, and after macroporous resin bed solvent elution, concentrate drying gets final product.By the absorption and the solvent elution of macroporous resin bed, the composition that major part is not had drug effect is adsorbed on the resin, and simultaneously above-mentioned active component is got off by solvent elution, makes that active ingredient has obtained purification in the extract.Method two: Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens are placed supercritical CO
2In the abstraction instrument, add solvent extraction.Resin separation purification technology and supercritical extraction technique in the extraction process of the present invention; all are one of crucial isolation technics of the modernization of Chinese medicine; its technology and equipment are advanced practical; enrichment the prescription in effective component group; can improve drug action; medical material utilization rate and reducing production costs; Chinese medicine is made the modernized dosage form that meets international standard; help also simultaneously that each medicine carries out clear and definite quantitative analysis among the other side; the standard that improves the quality is equipped with; can make the tradition prescription carry out further clinical application research such as the release of oral administration intestinal specificity controlled release drug; specific part begins degraded in vivo; discharge; guaranteed absorption strength; the medicine of protecting some easily to degrade under one's belt and losing efficacy, dual absorption hydrolyzate etc., dose will be reduced to about 1 gram every day in addition; broken through the big and thick tradition image of Chinese medicine; be easy to the patient and accept, meet the rhythm of the modern life, reduce patient's gastrointestinal drug and absorb the metabolism burden.Can see that thus the present invention has selected Chinese medicine advantage field, the modernized standard that possesses old prescription, new technology, new adjuvant, new equipment, effective ingredient is clear, effect is clear and definite, no obvious toxic-side effects, meet Chinese medicine modernization development in science and technology thinking and modernization of Chinese medicine industrial development direction, have very strong clinical value and exploitation future.
Extract of the present invention is to the animal central nervous system digestive system of unifying, and antiphlogistic influence test is found, this is subjected to multiple pharmacologically active effects such as the reagent thing has tangible calmness, calms the nerves, convulsion, antiinflammatory, facilitating digestion function, and there is not obvious toxic-side effects, animal normal physiological index there is not obvious influence, about its animal experiment effective dose 100mg/kg, be equivalent to about the clinical 10-20mg/kg of people.
The specific embodiment
Further specify the present invention below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate the present invention rather than limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent among the present invention is percetage by weight.
The preparation of embodiment 1 cape jasmine, ginger and fermented soybean total extract (1)
Fructus Gardeniae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens medical material or decoction pieces or process of preparing Chinese medicine decoction pieces are pulverized (three's ratio is 1.5: 1: 1.5), cross 20 mesh sieves, put and add ethanol extraction in the extraction pot, concentrate extracting solution centrifugal, ethanol elution reclaims after crossing the macropore resin bed, the dry extract that gets.
Extraction conditions: concentration of alcohol 15-80%, ethanol consumption 3-15 be doubly to the medical material amount, and extraction time 1-3 hour, extraction time 1-4 time.
The condition of concentrating: be concentrated into relative density 0.9-1.3
Centrifugal condition: centrifugal rotational speed 3000-30000rpm, centrifugation time 15-45min
Elution requirement: eluent concentration of alcohol 10-90%, eluent consumption 3-15 are doubly to medical material amount recovering condition: reclaim relative density 1.0-1.4
Experimental result: sample yield 5%, gardenoside content 20%, isoflavone content 6%, gingerol content 1%.
The preparation of embodiment 2 cape jasmine, ginger and fermented soybean total extracts (1)
With Fructus Gardeniae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens medical material or decoction pieces or concoct decoction pieces and pulverize (three's ratio is 4: 1: 2), cross 20 mesh sieves, put and add ethanol extraction in the extraction pot, extracting solution is concentrated centrifugal, cross the macropore resin bed after ethanol elution reclaim dry extract.
Extraction conditions: concentration of alcohol 15-80%, ethanol consumption 3-15 be doubly to the medical material amount, and extraction time 1-3 hour, extraction time 1-4 time.
The condition of concentrating: be concentrated into relative density 0.9-1.3
Centrifugal condition: centrifugal rotational speed 3000-30000rpm, centrifugation time 15-45min
Elution requirement: eluent concentration of alcohol 10-90%, eluent consumption 3-15 are doubly to medical material amount recovering condition: reclaim relative density 1.0-1.4
Experimental result: sample yield 5%, gardenoside content 60%, isoflavone content 3%, gingerol content 2%.
The preparation of embodiment 3 cape jasmine, ginger and fermented soybean total extracts (2)
Fructus Gardeniae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens medical material or decoction pieces or process of preparing Chinese medicine decoction pieces are pulverized (ratio of the two is 1: 2: 1), cross 20 mesh sieves, put supercritical CO
2Add alcohol extraction in the abstraction instrument;
Extraction conditions: pressure: 35Mpa, temperature: 45 ℃ (± 3 ℃);
Separation condition: the first separating still separation condition: pressure: 10Mpa, temperature: about 45 ℃;
The second separating still condition: pressure: 5Mpa, temperature: 40 ℃ (± 3 ℃);
Collect the second extraction kettle extract, sucking filtration, centrifugal, get oil reservoir and promptly get total extract (3).
Experimental result: sample yield 3%, gardenoside content 14%, isoflavone content 6%, gingerol content 5%.
The preparation of embodiment 4 cape jasmine, ginger and fermented soybean total extract tablets
Get the cape jasmine, ginger and fermented soybean total extract, mix with adjuvants such as lactose, magnesium stearate, microcrystalline Cellulose and add tablet forming, put into coating pan and add the coating solution coating.Nearly pathogenic wind-warm degree: 40 ℃, atomizing pressure: 3.5Kg, sheet bed tempertaure: 35 ℃, rotating speed: 4-10 minute, tablet weightening finish: 8%.The result shows: the smooth exquisiteness of tablet appearance, hide fully, and disintegrate is up to specification.
The preparation of embodiment 5 cape jasmine, ginger and fermented soybean total extract drop pill
Get cape jasmine, ginger and fermented soybean grass extract, with adjuvant heating and melting such as Polyethylene Glycol, mixed proportion stirs, in the impouring drop pill machine, splash under 80 ℃ of constant temperature in 5 ℃ of dimethyl-silicon wet goods condensed fluid, drip 35 droplets/minute of speed, drip apart from 5cm, leach drop pill, clean condensed fluid, packing is made drop pill promptly.
The result shows: drop pill rounding, industrial easy to operate, physical and chemical index is qualified.
Embodiment 6 cape jasmine, ginger and fermented soybean total extract preparation of soft capsule
Take by weighing in proportion in the putting glue jars such as gelatin, glycerol, water, 40-80 ℃ of water-bath glue, be molten state after, stir opacifiers such as adding titanium dioxide down, toners such as cacao brown.To be mixed evenly after, evacuation removes bubble.Glue and the cape jasmine, ginger and fermented soybean total extract handled well are added in capsule machine glue bucket and the hopper compacting respectively.Soft gelatin capsule was put to the high and dry chamber dry 24 hours, got qualified soft gelatin capsule promptly.
Embodiment 7. cape jasmine, ginger and fermented soybean total extract xylol cause the influence that the swelling of mice auricular concha and histamine cause ankle swelling in rat
Table 1, table 2 result of the test show, can be observed the pathological tissues swelling degree that embodiment 1 can obviously alleviate animal due to the modeling on animal mice, rat, and this result shows and is subjected to the reagent thing that certain antiinflammatory action is arranged.
Each medicine of table 1 is to the influence of mice auricular concha swelling
| Group | Dosage (mg/kg) | The example number | Cause scorching back two ear weight differences (mg) |
| Matched group | - | 10 | 19.5±2.3 |
| The aspirin group | 30 | 10 | 9.8±3.3** |
| Embodiment 1 | 200 | 10 | 13.0±1.9* |
| Embodiment 1 | 100 | 10 | 15.8±2.5* |
| Embodiment 1 | 50 | 10 | 17.65±4.2 |
Each medicine of table 2 is to the influence of ankle swelling in rat
| Group | Dosage (mg/kg) | The example number | Cause scorching back 1.0h two swollen ankles poor (cm) |
| Matched group | - | 10 | 9.7±1.3 |
| The aspirin group | 25 | 10 | 3.8±4.5** |
| Embodiment 1 | 180 | 10 | 5.9±1.5* |
| Embodiment 1 | 90 | 10 | 6.1±0.9* |
| Group | Dosage (mg/kg) | The example number | Cause scorching back 1.0h two swollen ankles poor (cm) |
| Embodiment 1 | 45 | 10 | 7.8±2.8 |
Annotate: compare * * P＜0.01 with matched group, * P＜0.05.
The collaborative pentobarbital sodium threshold of embodiment 8. cape jasmine, ginger and fermented soybean total extracts reaches the influence of threshold dose to the mice hypnosis time down
Table 3 result of the test shows that the cape jasmine, ginger and fermented soybean total extract can obviously prolong the length of one's sleep of mice under the pentobarbital sodium threshold dose; During the pentobarbital sodium sub-threshold dose, the cape jasmine, ginger and fermented soybean total extract can obviously increase the sleeping number of elements of mice, and this result shows and is subjected to the reagent thing that certain sedative-hypnotic effect is arranged.
The collaborative pentobarbital sodium of each medicine of table 3 is to the influence of mice sleep
| Group | Dosage (mg/kg) | The threshold dose min length of one's sleep | The sub-threshold dose number of animals of falling asleep | The sub-threshold dose rate % that falls asleep |
| Matched group | - | 28±10 | 2 | 20 |
| Embodiment 1 | 200 | 49±9* | 7 | 70* |
| Embodiment 1 | 100 | 44±10* | 5 | 50* |
| Embodiment 1 | 50 | 39±5 | 3 | 30 |
Annotate: compare * * P＜0.01 with matched group, * P＜0.05.
Embodiment 9. cape jasmine, ginger and fermented soybean total extracts are to the influence (carbon powder method) of mouse small intestine progradation,
Table 4 result of the test shows that the cape jasmine, ginger and fermented soybean total extract can obviously promote the progradation of mice intestinal, shows to be subjected to the reagent thing that certain promotion gastro-intestinal digestion creeping effect is arranged.
Each medicine of table 4 is to the propulsive influence of mice intestinal
Annotate: compare * * P＜0.01 with the blank group, * P＜0.05.
Embodiment 10. cape jasmine, ginger and fermented soybean total extracts are to the influence (writhing method) of mice analgesic activity
(1) experiment purpose
Table 5 result of the test shows that the cape jasmine, ginger and fermented soybean total extract can obviously reduce obvious minimizing mouse writhing number of times, and this result shows and be subjected to the reagent thing can resist the spasmic pain that glacial acetic acid causes that the animal brain nervous system is had certain analgesic activity.
Each medicine of table 5 is to the influence of mice analgesic activity
| Group | Dosage mg/kg | The animal number of elements only | Incubation period branch | Turn round the body number of times |
| Blank group | - | 15 | 5.47±1.55 | 30.12±10.04 |
| The tramadol group | 20 | 15 | 4.15±3.48 | 0.92±2.31** |
| Embodiment 1 | 200 | 15 | 5.89±2.15 | 20.37±8.89** |
| Embodiment 1 | 100 | 15 | 7.25±4.01 | 21.22±15.37* |
| Embodiment 1 | 50 | 15 | 5.01±3.25 | 18.69±12.23* |
Annotate: compare * * P＜0.01 with the blank group, * P＜0.05.
Embodiment 11. cape jasmine, ginger and fermented soybean total extracts are to rat gastric juice, pepsic influence test
Table 6 result of the test shows that the cape jasmine, ginger and fermented soybean total extract can significantly improve the effect of pepsin activity, shows to be subjected to the reagent thing that the digestive function that improves body is had certain facilitation.
Each medicine of table 6 is to rat gastric juice, pepsic influence
Annotate: compare * * P＜0.01 with model group, * P＜0.05.
Claims (8)
1. compound total extract of compound cape jasmine, ginger and fermented soybean is prepared from by Fructus Gardeniae, Semen Sojae Preparatum, three kinds of Chinese crude drugs of Rhizoma Zingiberis Recens, and wherein the weight fraction of Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens ratio is 1 part-5 parts: 1 part-3 parts: 1 part-5 parts.
2. compound total extract of compound cape jasmine, ginger and fermented soybean according to claim 1, wherein gardenoside content is 10%-80%, and soybean isoflavone is 2%-10%, and gingerol is 1%-8%.
3. the preparation method of claim 1 or 2 described compound total extract of compound cape jasmine, ginger and fermented soybean, it is characterized in that concentrating after Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens are with solvent extraction centrifugal, after the macroporous resin column solvent elution, concentrate drying gets final product, and wherein said solvent is the one or more combination in water, methanol, ethanol, n-butyl alcohol, the acetone.
4. the preparation method of claim 1 or 2 described compound total extract of compound cape jasmine, ginger and fermented soybean is characterized in that Fructus Gardeniae, Semen Sojae Preparatum and Rhizoma Zingiberis Recens place supercritical CO
2In the abstraction instrument, add alcohol extraction.
5. the preparation method of compound total extract of compound cape jasmine, ginger and fermented soybean according to claim 3, wherein said resin is a D-101 type adsorbent resin, XAD-2 type adsorbent resin, CHP-20P type adsorbent resin, SP825 type adsorbent resin or HP-20 type adsorbent resin.
6. compound recipe cape jasmine, ginger and fermented soybean extract formulation is characterized in that containing claim 1 or 2 described compound recipe cape jasmine, ginger and fermented soybean extract and pharmaceutically acceptable carriers.
7. compound recipe cape jasmine, ginger and fermented soybean extract formulation according to claim 8, the dosage form of described preparation is tablet, drop pill, capsule, exterior-applied emulsion, plaster, gel or injection.
8. claim 1 or the 2 described compound recipe cape jasmine, ginger and fermented soybean extracts application in the medicine of preparation treatment neurasthenia, upper respiratory tract infection, acute or chronic gastritis and insomnia.
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| ES2701758T3 (en) | 2013-02-27 | 2019-02-25 | Symrise Ag | Ginger extract for the protection of stem cells |
| CN104147183B (en) * | 2014-07-18 | 2016-08-24 | 中国人民解放军第二军医大学 | A kind of isolated and purified total iridoid glycoside and method of total soybean isoflavone from the Decoction of Capejasmine and Fermented Soybean |
| EP3097905B1 (en) | 2015-05-28 | 2020-11-04 | Symrise AG | Cosmetic compositions |
| CN105030754B (en) * | 2015-07-07 | 2017-08-22 | 中国药科大学 | A kind of pharmaceutical composition and its application with anti-inflammatory activity |
| EP3463275A1 (en) | 2016-05-30 | 2019-04-10 | Symrise AG | Cosmetic compositions comprising sclareolide |
| CN109329530A (en) * | 2018-12-20 | 2019-02-15 | 株洲千金药业股份有限公司 | Rattan chrysanthemum granules and its preparation method and application |
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| CN1579463A (en) * | 2003-08-08 | 2005-02-16 | 北京德润六合医药科技有限公司 | Compound cape-jasmine salted-fermented beans total extract and its preparation and use |
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