CN108392549A - A kind of resveratrol soft capsules and preparation method thereof with auxiliary lipid-lowering function - Google Patents
A kind of resveratrol soft capsules and preparation method thereof with auxiliary lipid-lowering function Download PDFInfo
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- CN108392549A CN108392549A CN201810272053.7A CN201810272053A CN108392549A CN 108392549 A CN108392549 A CN 108392549A CN 201810272053 A CN201810272053 A CN 201810272053A CN 108392549 A CN108392549 A CN 108392549A
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- parts
- glue
- resveratrol
- temperature
- gelatin
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- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title claims abstract description 26
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title claims abstract description 26
- 235000021283 resveratrol Nutrition 0.000 title claims abstract description 26
- 229940016667 resveratrol Drugs 0.000 title claims abstract description 26
- 239000007901 soft capsule Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 43
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000003814 drug Substances 0.000 claims abstract description 23
- 229940079593 drug Drugs 0.000 claims abstract description 21
- 108010010803 Gelatin Proteins 0.000 claims abstract description 20
- 239000002775 capsule Substances 0.000 claims abstract description 20
- 239000008273 gelatin Substances 0.000 claims abstract description 20
- 229920000159 gelatin Polymers 0.000 claims abstract description 20
- 235000019322 gelatine Nutrition 0.000 claims abstract description 20
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 20
- 235000011187 glycerol Nutrition 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- VYIRVAXUEZSDNC-TXDLOWMYSA-N (3R,3'S,5'R)-3,3'-dihydroxy-beta-kappa-caroten-6'-one Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC(=O)[C@]1(C)C[C@@H](O)CC1(C)C VYIRVAXUEZSDNC-TXDLOWMYSA-N 0.000 claims abstract description 16
- VYIRVAXUEZSDNC-LOFNIBRQSA-N Capsanthyn Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CC(O)CC2(C)C VYIRVAXUEZSDNC-LOFNIBRQSA-N 0.000 claims abstract description 16
- WRANYHFEXGNSND-LOFNIBRQSA-N capsanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CCC(O)C2(C)C WRANYHFEXGNSND-LOFNIBRQSA-N 0.000 claims abstract description 16
- 235000018889 capsanthin Nutrition 0.000 claims abstract description 16
- 238000004040 coloring Methods 0.000 claims abstract description 16
- 235000012658 paprika extract Nutrition 0.000 claims abstract description 16
- 239000001688 paprika extract Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 16
- 235000013761 grape skin extract Nutrition 0.000 claims abstract description 13
- 239000008213 purified water Substances 0.000 claims abstract description 11
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 239000003292 glue Substances 0.000 claims description 37
- 239000000463 material Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 8
- 239000000084 colloidal system Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 239000000049 pigment Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 230000007613 environmental effect Effects 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 3
- 238000004513 sizing Methods 0.000 claims description 3
- 238000009849 vacuum degassing Methods 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 235000013402 health food Nutrition 0.000 abstract description 2
- 231100001231 less toxic Toxicity 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 241000219095 Vitis Species 0.000 description 6
- 235000009754 Vitis X bourquina Nutrition 0.000 description 6
- 235000012333 Vitis X labruscana Nutrition 0.000 description 6
- 235000014787 Vitis vinifera Nutrition 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 208000032928 Dyslipidaemia Diseases 0.000 description 4
- 208000017170 Lipid metabolism disease Diseases 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 208000031226 Hyperlipidaemia Diseases 0.000 description 3
- 201000005577 familial hyperlipidemia Diseases 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000003605 opacifier Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 108010023302 HDL Cholesterol Proteins 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 244000153955 Reynoutria sachalinensis Species 0.000 description 2
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 description 2
- 208000034189 Sclerosis Diseases 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- -1 giant knotweed Chemical compound 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 239000008279 sol Substances 0.000 description 2
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 101100004288 Caenorhabditis elegans best-9 gene Proteins 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 240000006122 Chenopodium album Species 0.000 description 1
- 235000009344 Chenopodium album Nutrition 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 244000292697 Polygonum aviculare Species 0.000 description 1
- 235000006386 Polygonum aviculare Nutrition 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 241001593968 Vitis palmata Species 0.000 description 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000703 anti-shock Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000013367 dietary fats Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 239000001038 titanium pigment Substances 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of resveratrol soft capsules with auxiliary lipid-lowering function, it includes drug moiety and capsule shell parts, and the drug moiety is to be prepared by following raw material in parts by weight：60 80 parts of grape skin extract, 220 250 parts of polyethylene glycol 400；The capsule shell parts are to be prepared by following raw material in parts by weight：90 110 parts of gelatin, 40 50 parts of glycerine, 100 120 parts of purified water, 0.3 0.4 parts of burnt sugar coloring, 0.3 0.4 parts of capsanthin, 0.45 0.55 parts of titanium dioxide；It chooses safety, the grape skin extract of less toxic side effect is raw material, using resveratrol as main composition, a kind of health food with auxiliary lipid-lowering function for developing.
Description
Technical field
The present invention relates to blood fat reducing health products field more particularly to a kind of resveratrol with auxiliary lipid-lowering function are soft
Capsule and preparation method thereof.
Background technology
Dyslipidemia be often referred to cholesterol in blood plasma (TC) and（Or）Triglycerides（TG）It increases, is commonly called as hyperlipidemia.It is high
Pionemia belongs to the hearts such as atherosclerosis, coronary heart disease, the myocardial infarction that internal Dyslipidemia is made, is induced by Hyperlipemia
Vascular diseases seriously threaten human health.Blood fat height has substantial connection with ordinary meal intake and in vivo metabolism.With
Improvement of living standard, people's dietary fat intake increase, and fat energy supply has been more than the 30% of gross energy in some crowds,
High lipid diet has been the specific risk factor of hyperlipidemia.At present the treatment such as drug-treated of the chronic diseases such as dyslipidemia and
Medical procedure（Operation）The effect played is very small.The prevention and treatment of dyslipidemia is mainly controlled using drug therapy with non-drug
Treat the mode being combined.Clinically the drug of common line reducing blood lipid is Statins, this kind of drug norcholesterol (TC) effect
It is most strong, at the same also can triglyceride reducing (TG) and increasing high density lipoprotein cholesterol (HDL-C), to effectively control blood fat.
But drug used can only play the role of controlling blood fat, and side effect is more, cannot fundamentally prevent and adjust blood fat.And meals
Tonic fill, intervene be metabolic disease Primary Care, hyperlipemia treatment in it is extremely important.Therefore, pass through natural plants
Active constituent adjusts blood fat to prevent the disease caused by hyperlipidemia, it has also become the hot spot of current healthcare research.
Invention content
The purpose of the present invention is provide a kind of with auxiliary lipid-lowering function in view of the deficiencies of the prior art mentioned above
Resveratrol soft capsules and preparation method thereof.
In order to solve the above-mentioned technical problem, the technical solution used in the present invention is：One kind having auxiliary lipid-lowering function
Resveratrol soft capsules, it includes drug moiety and capsule shell parts, and the drug moiety is by the original of following parts by weight
Material is prepared：60-80 parts of grape skin extract, 220-250 parts of polyethylene glycol 400；The capsule shell parts are by following heavy
The raw material of amount number is prepared：90-110 parts of gelatin, 40-50 parts of glycerine, 100-120 parts of purified water, burnt sugar coloring 0.3-0.4
Part, 0.3-0.4 parts of capsanthin, 0.45-0.55 parts of titanium dioxide.
The preparation method of the above-mentioned resveratrol soft capsules with auxiliary lipid-lowering function includes the following steps：
1), the preparation of glue：
A. colloidal sol：Gelatin, glycerine, purified water, titanium dioxide, burnt sugar coloring, capsanthin are weighed by formula rate.By titanium dioxide plus
Qs glycerin crosses colloid mill after stirring evenly；Burnt sugar coloring and a small amount of purifying water dissolution of capsanthin, stir evenly, spare；Purifying
Water, glycerine inputization glue tank, while the blender on tank is started, wait for that temperature reaches about 70 DEG C in tank, puts into gelatin, and continue to add
To 75 DEG C, insulated and stirred is added titania solution and pigment solution, insulated and stirred about 0.5 is small heat until gelatin all dissolves
When.Obtain glue mixed material；
B. it vacuumizes：Glue mixed material is vacuumized（Vacuum degree -0.08MPa, 75 DEG C of temperature）To glue without tiny intensive gas
Bubble deflates, obtains glue；
C. it filters：Glue after deflation is sieved with 100 mesh sieve into net；
D. it stands：Releasing glue, which is placed in steady glue bucket, stands 2h, keeps 55~60 DEG C of glue, spare；
2), the preparation of pharmaceutical compositions
Polyethylene glycol 400 is weighed by formula ratio, the grape skin extract of formula ratio is added, stirs 15min, crosses colloid mill, vacuum
Degassing（Vacuum degree -0.07Mpa）, obtain total mixture；
3）, pelleting
Pharmaceutical compositions and glue are placed in soft capsule pellet press respectively, are pressed into soft capsule（58~65 DEG C of glue box temperature, sprinkler body
37~47 DEG C of temperature, humidity 40% ± 5%）, 18~26 DEG C of environment temperature, every dress 0.3g ± 5% of content；
4）, rotating cage sizing, 18~26 DEG C of temperature, relative humidity 30~45% places oil absorbing cloth in rotating cage, and setting time is 2h；
5）, it is dry：20~25 DEG C of room temperature, 20~30% environmental drying of relative humidity 24 hours；
6）, select ball, pick oil leak, the substandard products such as deformity；
7）, bottling, 60 every bottle.
The present invention pharmacology be with advantageous effect：Natural products of the resveratrol as plants such as grape, giant knotweeds.In the people
Between, already hyperlipemia, artery sclerosis are treated and prevented with the Chinese medicine rich in resveratrol such as giant knotweed, the tuber of multiflower knotweed.Drink red Portugal
The probability that the people of grape wine custom suffers from angiocardiopathy substantially reduces, because the resveratrol in grape wine can reduce human serum lipid
It is horizontal.With further investigation in recent years, display resveratrol has anti-oxidant, prevention low-density lipoprotein（LDL）Oxidation；
Antiatherosclerosis and coronary heart disease；Blood fat is adjusted, blood cholesterol is reduced；Inhibit platelet aggregation, antithrombotic；It is anti-
Shock promotes microcirculation；Antibacterial, anti-inflammatory；Inhibit canceration, prevents cytogenetics from making a variation；It is the effects that estrogen-like action, wide
It is applied to the fields such as medicine, health products, food generally.Treatment angiocardiopathy, artery sclerosis and height are widely used in drug
The diseases such as blood fat.Using resveratrol as a kind of dietary supplements, Japan adds resveratrol as food additives in the U.S.
Into various wine, the new type of health for making the low alcohol, high resveratrol that have good prevention effect to angiocardiopathy is gone with rice or bread wine；
The natural health care of lipid-loweringing, beauty and weight-reducing has been made in the plant extracts of resveratrol by China.As it can be seen that numerous at its
In effect, blood fat is adjusted, the effect of prevention of cardiovascular disease is especially prominent, is most widely used.Resveratrol is present in a variety of
In human foods, such as mulberry fruit, peanut, pine apple nanas, grape, there is higher safety in utilization.Polyphenol content in red grape pomace
Up to 25%~50%, up to 50%~70% in seed.Polyphenol mainly has anthocyan, resveratrol and flavonoids in pericarp.
Grape skin extract used in this product is exactly using the pericarp of edible grape as raw material, extracted, higher white lamb's-quarters obtained by purifying
The grape skin extract of reed alcohol content, safety can ensure that therefore, we choose the Portugal of safe, less toxic side effect
Grape bark extract is raw material, using resveratrol as main composition, a kind of guarantor with auxiliary lipid-lowering function for developing
Health food.
The basic components of the softgel shell of the present invention use the common gelatin of soft capsule and water, and using glycerine as plasticizer；
With the increase of the ratio of dampening, glue is by sticky thinning, by experiment it is found that gelatin and water are with 1:1.1 ratio is relatively mild.It is sweet
Oil is plasticizer, and with the increase of amounts of glycerol, softgel shell softens, and disintegration time limited shortens.But amounts of glycerol is excessive, and the forming of utricule is not
Good, drug easily oozes out.When gelatin, glycerol and water ratio are 1：0.4~0.5：When 1.1, gained softgel shell is neither too hard, nor too soft, accordingly, is
Ensure the stabilization of product quality, selection gelatin：Glycerine：Water is 1:0.45:1.1 ratio prepares capsule material；It is added in capsule shells
Pigment and opacifier can make capsule shells opaque, and reduce capsule shells is influenced by illumination, when selecting pigment and opacifier, examines
The color and luster for considering softgel shell is deeper than capsule 's content, and compatibility reaction does not occur between capsule 's content and softgel shell, in summary selects
It selects opacifier titanium dioxide and pigment burnt sugar coloring, capsanthin is softgel shell auxiliary material, and is screened to its dosage, with the shading of softgel shell
Effect and aesthetics carry out visually rank, as a result see the table below：
| Serial number | Titanium dioxide（%） | Burnt sugar coloring（%） | Capsanthin（%） | Shaded effect |
| 1 | 0.1 | 0.1 | 0.1 | Difference |
| 2 | 0.1 | 0.15 | 0.15 | In |
| 3 | 0.1 | 0.2 | 0.2 | It is good |
| 4 | 0.15 | 0.1 | 0.1 | Difference |
| 5 | 0.15 | 0.15 | 0.15 | It is good |
| 6 | 0.15 | 0.2 | 0.2 | It is good |
| 7 | 0.2 | 0.1 | 0.1 | It is good |
| 8 | 0.2 | 0.15 | 0.15 | It is best |
| 9 | 0.2 | 0.2 | 0.2 | It is best |
By investigation result it is found that when 0.2% that titanium dioxide is adhesive liquid quantity, burnt sugar coloring and capsanthin are the 0.15% of adhesive liquid quantity
When, light-proofness is best, therefore determines that amount of titanium is the 0.2% of adhesive liquid quantity, and burnt sugar coloring dosage is the 0.15% of adhesive liquid quantity, capsicum
Red is the 0.15% of adhesive liquid quantity.
Description of the drawings
Fig. 1 is the process flow diagram of the present invention.
Specific implementation mode
With reference to embodiment, embodiment of the present invention is described further.
Embodiment 1
The resveratrol soft capsules with auxiliary lipid-lowering function of the present invention, it includes drug moiety and capsule shell parts, institute
It is to be prepared by following raw material in parts by weight to state drug moiety：62 parts of grape skin extract, 230 parts of polyethylene glycol 400；
The capsule shell parts are to be prepared by following raw material in parts by weight：93 parts of gelatin, 42 parts of glycerine, 105 parts of purified water, coke
0.32 part of fried sugar, 0.33 part of capsanthin, 0.48 part of titanium dioxide.
The preparation method of the above-mentioned resveratrol soft capsules with auxiliary lipid-lowering function includes the following steps：
1), the preparation of glue：
A. colloidal sol：Gelatin, glycerine, purified water, titanium dioxide, burnt sugar coloring, capsanthin are weighed by formula rate.By titanium dioxide plus
Qs glycerin crosses colloid mill after stirring evenly；Burnt sugar coloring and a small amount of purifying water dissolution of capsanthin, stir evenly, spare；Purifying
Water, glycerine inputization glue tank, while the blender on tank is started, wait for that temperature reaches about 70 DEG C in tank, puts into gelatin, and continue to add
To 75 DEG C, insulated and stirred is added titania solution and pigment solution, insulated and stirred about 0.5 is small heat until gelatin all dissolves
When.Obtain glue mixed material；
B. it vacuumizes：Glue mixed material is vacuumized（Vacuum degree -0.08MPa, 75 DEG C of temperature）To glue without tiny intensive gas
Bubble deflates, obtains glue；
C. it filters：Glue after deflation is sieved with 100 mesh sieve into net；
D. it stands：Releasing glue, which is placed in steady glue bucket, stands 2h, keeps 55~60 DEG C of glue, spare；
2), the preparation of pharmaceutical compositions
Polyethylene glycol 400 is weighed by formula ratio, the grape skin extract of formula ratio is added, stirs 15min, crosses colloid mill, vacuum
Degassing（Vacuum degree -0.07Mpa）, obtain total mixture；
3）, pelleting
Pharmaceutical compositions and glue are placed in soft capsule pellet press respectively, are pressed into soft capsule（58~65 DEG C of glue box temperature, sprinkler body
37~47 DEG C of temperature, humidity 40% ± 5%）, 18~26 DEG C of environment temperature, every dress 0.3g ± 5% of content；
4）, rotating cage sizing, 18~26 DEG C of temperature, relative humidity 30~45% places oil absorbing cloth in rotating cage, and setting time is 2h；
5）, it is dry：20~25 DEG C of room temperature, 20~30% environmental drying of relative humidity 24 hours；
6）, select ball, pick oil leak, the substandard products such as deformity；
7）, bottling, 60 every bottle.
Embodiment 2
The resveratrol soft capsules with auxiliary lipid-lowering function of the present invention, it includes drug moiety and capsule shell parts, institute
It is to be prepared by following raw material in parts by weight to state drug moiety：69 parts of grape skin extract, 238 parts of polyethylene glycol 400；
The capsule shell parts are to be prepared by following raw material in parts by weight：100 parts of gelatin, 45 parts of glycerine, 111 parts of purified water,
0.35 part of burnt sugar coloring, 0.36 part of capsanthin, 0.49 part of titanium dioxide, preparation method is the same as embodiment 1.
Embodiment 3
The resveratrol soft capsules with auxiliary lipid-lowering function of the present invention, it includes drug moiety and capsule shell parts, institute
It is to be prepared by following raw material in parts by weight to state drug moiety：73 parts of grape skin extract, 243 parts of polyethylene glycol 400；
The capsule shell parts are to be prepared by following raw material in parts by weight：105 parts of gelatin, 47 parts of glycerine, 116 parts of purified water,
0.38 part of burnt sugar coloring, 0.38 part of capsanthin, 0.5 part of titanium dioxide, preparation method is the same as embodiment 1.
Embodiment 4
The resveratrol soft capsules with auxiliary lipid-lowering function of the present invention, it includes drug moiety and capsule shell parts, institute
It is to be prepared by following raw material in parts by weight to state drug moiety：79 parts of grape skin extract, 248 parts of polyethylene glycol 400；
The capsule shell parts are to be prepared by following raw material in parts by weight：108 parts of gelatin, 48 parts of glycerine, 118 parts of purified water,
0.39 part of burnt sugar coloring, 0.38 part of capsanthin, 0.53 part of titanium dioxide, preparation method is the same as embodiment 1.
Claims (2)
1. a kind of resveratrol soft capsules with auxiliary lipid-lowering function, it is characterised in that：It includes drug moiety and capsule
Shell parts, the drug moiety are to be prepared by following raw material in parts by weight：60-80 parts of grape skin extract, poly- second two
400 220-250 parts of alcohol；The capsule shell parts are to be prepared by following raw material in parts by weight：It is 90-110 parts of gelatin, sweet
40-50 parts oily, 100-120 parts of purified water, 0.3-0.4 parts of burnt sugar coloring, 0.3-0.4 parts of capsanthin, titanium dioxide 0.45-0.55
Part.
2. a kind of method preparing the resveratrol soft capsules with auxiliary lipid-lowering function described in claim 1, feature exist
In：It the described method comprises the following steps：
1), the preparation of glue：
A. colloidal sol：Gelatin, glycerine, purified water, titanium dioxide, burnt sugar coloring, capsanthin are weighed by formula rate；
By titanium dioxide plus qs glycerin, colloid mill is crossed after stirring evenly；Burnt sugar coloring and a small amount of purifying water dissolution of capsanthin, are stirred
It mixes uniformly, it is spare；Purified water, glycerine inputization glue tank, while the blender on tank is started, wait for that temperature reaches about 70 DEG C in tank,
Gelatin is put into, and continues to be heated to 75 DEG C, insulated and stirred is added titania solution and pigment is molten until gelatin all dissolves
Liquid, insulated and stirred about 0.5 hour；
Obtain glue mixed material；
B. it vacuumizes：Glue mixed material is vacuumized（Vacuum degree -0.08MPa, 75 DEG C of temperature）To glue without tiny intensive gas
Bubble deflates, obtains glue；
C. it filters：Glue after deflation is sieved with 100 mesh sieve into net；
D. it stands：Releasing glue, which is placed in steady glue bucket, stands 2h, keeps 55~60 DEG C of glue, spare；
2), the preparation of pharmaceutical compositions
Polyethylene glycol 400 is weighed by formula ratio, the grape skin extract of formula ratio is added, stirs 15min, crosses colloid mill, vacuum
Degassing（Vacuum degree -0.07Mpa）, obtain total mixture；
3）, pelleting
Pharmaceutical compositions and glue are placed in soft capsule pellet press respectively, are pressed into soft capsule（58~65 DEG C of glue box temperature, sprinkler body
37~47 DEG C of temperature, humidity 40% ± 5%）, 18~26 DEG C of environment temperature, every dress 0.3g ± 5% of content；
4）, rotating cage sizing, 18~26 DEG C of temperature, relative humidity 30~45% places oil absorbing cloth in rotating cage, and setting time is 2h；
5）, it is dry：20~25 DEG C of room temperature, 20~30% environmental drying of relative humidity 24 hours；
6）, select ball, pick oil leak, the substandard products such as deformity；
7）, bottling, 60 every bottle.
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| CN201810272053.7A CN108392549A (en) | 2018-03-29 | 2018-03-29 | A kind of resveratrol soft capsules and preparation method thereof with auxiliary lipid-lowering function |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112121113A (en) * | 2019-06-25 | 2020-12-25 | 上海春芝堂生物制品有限公司 | Antioxidant grape skin extract plant soft capsule and preparation method thereof |
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| CN1559290A (en) * | 2004-02-18 | 2005-01-05 | 上海纳贝生物技术有限责任公司 | Health-care food soft capsule, and its prepn. method |
| CN104224890A (en) * | 2014-07-29 | 2014-12-24 | 中宏生物工程有限责任公司 | Lutein soft capsule and preparation method thereof |
| CN106072563A (en) * | 2016-06-29 | 2016-11-09 | 广州联存医药科技股份有限公司 | A kind of health composition with function of physical fatigue alleviation and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559290A (en) * | 2004-02-18 | 2005-01-05 | 上海纳贝生物技术有限责任公司 | Health-care food soft capsule, and its prepn. method |
| CN104224890A (en) * | 2014-07-29 | 2014-12-24 | 中宏生物工程有限责任公司 | Lutein soft capsule and preparation method thereof |
| CN106072563A (en) * | 2016-06-29 | 2016-11-09 | 广州联存医药科技股份有限公司 | A kind of health composition with function of physical fatigue alleviation and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112121113A (en) * | 2019-06-25 | 2020-12-25 | 上海春芝堂生物制品有限公司 | Antioxidant grape skin extract plant soft capsule and preparation method thereof |
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Application publication date: 20180814 |