CN101637481B - Prescription of gingkgo leaf soft capsule and preparation method thereof - Google Patents
Prescription of gingkgo leaf soft capsule and preparation method thereof Download PDFInfo
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- CN101637481B CN101637481B CN2009101624374A CN200910162437A CN101637481B CN 101637481 B CN101637481 B CN 101637481B CN 2009101624374 A CN2009101624374 A CN 2009101624374A CN 200910162437 A CN200910162437 A CN 200910162437A CN 101637481 B CN101637481 B CN 101637481B
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Abstract
The invention discloses a prescription of a gingkgo leaf soft capsule and a preparation method thereof. The soft capsule consists of two parts of liquid medicine and a softgel shell, wherein the liquid medicine contains gingkgo leaf extract and soya bean lecithin, and the weight percent of the gingkgo leaf extract and the soya bean lecithin is 1:8-2:1. The softgel shell is made by using gelatin, glycerin and water with the weight percent of 1:(0.3-0.6):(0.6-1.2); and the soft capsule is made by the confected liquid medicine and softgel shell with a pressing method for preventing and treating cerebrovascular disease, and the like. The invention has the advantages of simple technique, scientific prescription, convenient operation and low cost.
Description
Technical field
The present invention relates to a kind of prescription and preparation technology thereof of ginkgo leaf soft capsule
Background technology
Semen Ginkgo has very long medicinal in China, edible history have the title of living fossil.According to " Treatise on Dietetic Therapy " record, its can be used for cardiopalmus seized with terror in, diseases such as cough and asthma due to lung deficiency.Contain flavone compound in the modern medicine study proof Folium Ginkgo; Bioactive ingredients such as terpenoid, these compositions have quite intensive antioxidation, can remove free radical superfluous in the organism; Stop the body lipid peroxidating, improve the immunity of body etc.Its flavones ingredient, the ability coronary dilating; Improve the heart, cerebral blood circulation reduces serum cholesterol, also has high antiallergic, shock, and effects such as anti-organ transplant rejection are the natural drugs of the treatment cardiovascular and cerebrovascular disease of first-selection.
Lecithin can emulsifying, cut grease, and can will change into micropartical attached to cholesterol on the blood vessel wall and fat milk, makes it to be dissolved in to transport liver in the blood back and by metabolism.Play vessel softening, improve serum lipids, remove the effect of peroxide, make cholesterol and fat content reduction in the blood, thereby reduce the blood stickiness, promote blood circulation, reduce fat in the endovascular holdup time.And then, make nutritious, contain the competent blood of oxygen, flow to organs such as brain, heart unblockedly.Clinical experiment was once done by medical college food nutrition system of Japan keio university; And reach a conclusion: through taking lecithin; Can effectively reduce too high blood fat and cholesterol, and then prevent and treat diseases such as coronary heart disease, hypertension, myocardial infarction, cerebral thrombosis, cerebral hemorrhage, arteriosclerosis.
The various dosage forms of ginkgo agent medicine and health product all receive the welcome in market, and tablet, injection become the leading dosage form in preparation market, and capsule, drop pill have also been showed good development potentiality.Soft capsule is a most popular peroral dosage form in the world today, with respect to dosage forms such as tablet and hard capsules, has removed disintegrate in the body from, disperses, and the process of stripping makes effective ingredient more be prone to stripping; With respect to injection, characteristics such as easy to carry, safe in utilization are arranged.Soft capsule can overcome the shortcoming of existing dosage form, and steady quality is arranged, and carries taking convenience, but advantage such as the outward appearance impression is strong, and is safe in utilization.
Chinese patent 200410087855.9; 200510002416.8; 200510033392.2 three patents all disclose a kind of conventional way of ginkgo leaf soft capsule; But these three kinds of methods all are simply to make this dosage form of soft capsule to Folium Ginkgo extract, and Chinese patent 200710195092.3 discloses the health product compounds of forming with lecithin and Folium Ginkgo extract, but also are to have made up lecithin and Folium Ginkgo extract simply.The present invention is dissolved the content medicinal liquid of Folium Ginkgo extract as soft capsule with soybean lecithin; Get final product so that capsular quality is improved; It is bad to have solved the Folium Ginkgo extract dissolubility again, the problem that bioavailability is not high, simultaneously; Soybean lecithin itself just has the pharmacological action of blood lipid regulation, and the medication adjuvant can be that the pharmacy worker pursues to the effect that principal agent plays collaborative or enhancing treatment effect always.
The present invention has overcome the deficiency of prior art, is primary raw material with Folium Ginkgo extract and soybean lecithin, has developed a kind of preparation of soft capsule method of preventing and treating cardiovascular and cerebrovascular disease.
Summary of the invention
The object of the invention provides a kind of dissolubility and bioavailability that improves Folium Ginkgo extract, strengthens prescription of the soft capsule of preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof.
The present invention treats the cardiovascular and cerebrovascular vessel soft capsule with Folium Ginkgo extract, and soybean lecithin is that primary raw material is processed.
Technical scheme of the present invention is, makes the medicinal liquid in the capsule softgel shell with soybean lecithin dissolving Folium Ginkgo extract, and the weight ratio of Folium Ginkgo extract and soybean lecithin is in the medicinal liquid: 1: 8～2: 1; Use gelatin, glycerol, the weight proportion of water 1: 0.3～0.6: 0.6～1.2 during the making of softgel shell; Can when the making of medicinal liquid and softgel shell, add diluent, suspending agent, surfactant; Antiseptic, one or more in the antioxidant.
Ginkgo leaf soft capsule of the present invention, preferred component is: the weight ratio of Folium Ginkgo extract and soybean lecithin is: 1: 3; When making, softgel shell uses gelatin, glycerol, the weight proportion of water 1: 0.4: 0.9.
The manufacture method of ginkgo leaf soft capsule of the present invention is that Folium Ginkgo extract is added in the soybean lecithin, after at room temperature fully stirring, on the soft capsule press, suppress, again through cleaning, dry and soft capsule.
The method for making of softgel shell is: gelatin added in the Stainless Steel glue pot, adds suitable quantity of water again, and sealing, 70 ℃ are incubated 3 hours, add an amount of glycerol again, and vacuumize degassing 2 hours is put into 70 ℃ of insulations of gelatin bucket hold over night, supplies the preparation soft capsule to use.
The specific embodiment
Case study on implementation 1
Form umber (by weight)
1 part of Folium Ginkgo extract
3 parts of soybean lecithins
2 parts of glycerol
5 parts in gelatin
The preparation of softgel shell: get 5 parts in gelatin, add while stirring in 4.25 parts of water, 70 ℃ are incubated 3 hours, and the dissolving back adds 2 parts of glycerol fully, stirs, and vacuumize degassing, 70 ℃ are incubated hold over night, for use.
1 part of Folium Ginkgo extract (crossing 100 mesh sieves) is got in softgel shell content medicinal liquid and capsular preparation, with 3 parts soybean lecithin dissolvings wherein; Stir, vacuumize degassing remains at content and to be higher than 40 ℃; 37 ℃-50 ℃ of control sprinkler body temperature, colloid temperature are controlled at pelleting under 55 ℃-65 ℃ the condition, again through qualitative drying; Wash ball, the ball operation of drying in the air promptly gets.
Case study on implementation 2
Form umber (by weight)
1 part of Folium Ginkgo extract
5.8 parts of soybean lecithins
2.2 parts of glycerol
4.3 parts in gelatin
The preparation of softgel shell: get 4.3 parts in gelatin, add while stirring in 3.8 parts of water, 70 ℃ are incubated 3 hours, and the dissolving back adds 2.2 parts of glycerol fully, stirs, and vacuumize degassing, 70 ℃ are incubated hold over night, for use.
1 part of Folium Ginkgo extract (crossing 100 mesh sieves) is got in softgel shell content medicinal liquid and capsular preparation, with 5.8 parts soybean lecithin dissolvings wherein; Stir, vacuumize degassing remains at content and to be higher than 40 ℃; 37 ℃-50 ℃ of control sprinkler body temperature, colloid temperature are controlled at pelleting under 55 ℃-65 ℃ the condition, again through qualitative drying; Wash ball, the ball operation of drying in the air promptly gets.
Case study on implementation 3
Form umber (by weight)
1 part of Folium Ginkgo extract
4.2 parts of soybean lecithins
1.8 parts of glycerol
3.8 parts in gelatin
0.01 part of sorbic acid methyl ester
0.03 part of mud moor gold ethyl ester
The preparation of softgel shell: get 3.8 parts in gelatin, add while stirring in 3.5 parts of water, 70 ℃ are incubated 3 hours, and the dissolving back adds 1.8 parts of glycerol fully, and 0.01 part of sorbic acid methyl ester stirs, vacuumize degassing, and 70 ℃ are incubated hold over night, for use.
1 part of Folium Ginkgo extract (crossing 100 mesh sieves) is got in softgel shell content medicinal liquid and capsular preparation, with 4.2 parts soybean lecithin dissolvings wherein, stirs; Get 0.03 part of mud moor gold ethyl ester again, stir, vacuumize degassing remains at content and to be higher than 40 ℃; 37 ℃-50 ℃ of control sprinkler body temperature, colloid temperature are controlled at pelleting under 55 ℃-65 ℃ the condition, again through qualitative drying; Wash ball, the ball operation of drying in the air promptly gets.
Claims (2)
1. ginkgo leaf soft capsule comprises the medicinal liquid of following composition in soft capsule shell: Folium Ginkgo extract and soybean lecithin, and wherein, the weight ratio of Folium Ginkgo extract and soybean lecithin is: 1: 3; When making, softgel shell uses gelatin, glycerol, the weight proportion of water 1: 0.4: 0.9; And Folium Ginkgo extract joined in the soybean lecithin, after at room temperature fully stirring, on the soft capsule press, suppress, again through cleaning, dry and obtain soft capsule.
2. ginkgo leaf soft capsule according to claim 1 is characterized in that: can add adjuvant: its classification can be diluent, suspending agent, surfactant, antiseptic, one or more in the antioxidant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009101624374A CN101637481B (en) | 2009-08-05 | 2009-08-05 | Prescription of gingkgo leaf soft capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101624374A CN101637481B (en) | 2009-08-05 | 2009-08-05 | Prescription of gingkgo leaf soft capsule and preparation method thereof |
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| CN101637481A CN101637481A (en) | 2010-02-03 |
| CN101637481B true CN101637481B (en) | 2012-07-11 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127580A (en) * | 2014-06-30 | 2014-11-05 | 江苏伟楼生物科技有限公司 | Ginkgo softgel and preparation method thereof |
| CN111249445B (en) * | 2020-02-27 | 2022-11-15 | 广东医科大学 | Cytochalasin H soft capsule and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1421208A (en) * | 2001-11-22 | 2003-06-04 | 中国科学院地理科学与资源研究所 | Compound prepn containing alpha-linolic acid, lecithin and ginkgetin |
| CN1634428A (en) * | 2004-11-01 | 2005-07-06 | 辽宁大生药业有限公司 | Ginkgo leaf soft capsule and preparation technique thereof |
| CN1682884A (en) * | 2005-03-03 | 2005-10-19 | 深圳海王药业有限公司 | Ginkgo leaf soft capsule and its preparing method |
| CN101224260A (en) * | 2006-12-13 | 2008-07-23 | 天津市弗兰德医药科技发展有限公司 | Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract |
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2009
- 2009-08-05 CN CN2009101624374A patent/CN101637481B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1421208A (en) * | 2001-11-22 | 2003-06-04 | 中国科学院地理科学与资源研究所 | Compound prepn containing alpha-linolic acid, lecithin and ginkgetin |
| CN1634428A (en) * | 2004-11-01 | 2005-07-06 | 辽宁大生药业有限公司 | Ginkgo leaf soft capsule and preparation technique thereof |
| CN1682884A (en) * | 2005-03-03 | 2005-10-19 | 深圳海王药业有限公司 | Ginkgo leaf soft capsule and its preparing method |
| CN101224260A (en) * | 2006-12-13 | 2008-07-23 | 天津市弗兰德医药科技发展有限公司 | Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract |
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Owner name: BEIJING HUARUN HIGH-TECH NATURAL PHARMACEUTICAL CO Free format text: FORMER NAME: SHUANGHE HIGH-TECH. NATURAL MEDICINE CO., LTD., BEIJING |
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Address after: Yanqing Town, Beijing city Yanqing County 102100 Guishui No. 11 South Street Patentee after: Beijing Huarun Gaoke Natural Medicine Co., Ltd. Address before: Yanqing Town, Beijing city Yanqing County 102100 Guishui No. 11 South Street Patentee before: Shuanghe High-Tech. Natural Medicine Co., Ltd., Beijing |