CN1682884A - Ginkgo leaf soft capsule and its preparing method - Google Patents
Ginkgo leaf soft capsule and its preparing method Download PDFInfo
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- CN1682884A CN1682884A CN 200510033392 CN200510033392A CN1682884A CN 1682884 A CN1682884 A CN 1682884A CN 200510033392 CN200510033392 CN 200510033392 CN 200510033392 A CN200510033392 A CN 200510033392A CN 1682884 A CN1682884 A CN 1682884A
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- folium ginkgo
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Abstract
The soft gingko leaf capsule consists of two parts, including medicine liquid and outer covering. The medicine liquid contains volatile gingko leaf oil and vegetable oil in the weight ratio of 0.25-4, and the vegetable oil is soybean oil, corn oil, peanut oil, tea seed oil or their mixture. The outer covering is prepared with gelatin, glycerin and water in the weight ratio of 1 to 0.2-0.5 to 0.7-1.3. The preparation process of the soft gingko leaf capsule includes extracting volatile gingko leaf oil, and pressing the soft capsule. The soft gingko leaf capsule is used in preventing and treating cardiac and cerebral vascular diseases and other diseases.
Description
Technical field
The present invention relates to a kind of medicine of preventing and treating cardio-cerebrovascular diseases, relate in particular to a kind of ginkgo leaf soft capsule and preparation method thereof.
Background technology
Ginkgoaceae Ginkgo plant Ginkgo biloba (Ginkgo biloba L.) is one of the most ancient in the world seeds, has the title of living fossil.Semen Ginkgo can be used as medicine, and has promoting blood circulation and stopping pain, effects such as relieving cough and asthma, and Folium Ginkgo is compared Semen Ginkgo and is then had higher medical value.
The chemical analysis complexity of Folium Ginkgo includes multiple chemical compounds such as flavonoid, terpenoid esters, phenols, aliphatic alcohol.In recent years, owing to finding that Folium Ginkgo extract has the effect for the treatment of cardiovascular and cerebrovascular disease and receives people's concern.
What research was more in the Folium Ginkgo extract is compositions such as lactone, flavone, use at present the Folium Ginkgo tablet made with bilobalide, flavone, injection, capsule, soft capsule etc. clinically and be used to prevent and treat cardio-cerebrovascular diseases, relevant report is also very many, disclose a kind of to contain flavonoid more than 24% as Chinese patent 03133575.6 " Semen Ginkgo extrac self-emulsifying soft capsule and preparation method thereof ", the Folium Ginkgo extract of lactone more than 6% is main active, in addition the Folium Ginkgo extract self-emulsifying soft capsule of co-emulsifier, emulsifying agent and oil phase preparation; Chinese patent 02128964.6 " bilobalide soft capsule and preparation method thereof " and Chinese patent 02134330.6 " a kind of bilobalide soft capsule and preparation method thereof " disclose the soft capsule with the bilobalide preparation; But the research of relevant Folium Ginkgo volatile oil report is less.
Nineteen ninety-five, Peng Hong etc. identify contain in the Folium Ginkgo volatile oil 17 kinds of compositions (Peng Hong Guo Zhen moral etc. the Guangzhou chemistry, 1995,92:36-37); People such as Zhou Weishu in 1997 in Folium Ginkgo volatile oil, be divided into from, identify 35 compositions, comprise classes of compounds such as carboxylic acid, phenol, ketone, ester, alkene, wherein farnesane derivant composition accounts for 43.24% of volatile oil total amount.(Zhou Weishu Zhou Zhen, Chinese Pharmaceutical Journal, 1999,34 (5): 353), but be the ginkgo leaf soft capsule of Main Ingredients and Appearance with the Folium Ginkgo volatile oil and use and do not appear in the newspapers as yet.
Summary of the invention
The object of the present invention is to provide a kind of ginkgo leaf soft capsule, this soft capsule is a main component with Folium Ginkgo volatile oil and vegetable oil, not only have cardiovascular, anti-hypoxia isoreactivity, and have the characteristics of safe in utilization, steady quality, evident in efficacy, taking convenience.
Another object of the present invention is to provide the preparation method of above-mentioned ginkgo leaf soft capsule.
The technical solution adopted for the present invention to solve the technical problems is that a kind of ginkgo leaf soft capsule is sealed the medicinal liquid that contains following composition: Folium Ginkgo volatile oil and vegetable oil in soft capsule shell; The weight ratio of Folium Ginkgo volatile oil and vegetable oil is in the medicinal liquid: 1: 4～4: 1, vegetable oil was selected from a kind of or wherein several mixture in soybean oil, Semen Maydis oil, Oleum Arachidis hypogaeae semen, the Oleum Camelliae.The weight proportion 1: 0.2～0.5: 0.7～1.3 of gelatin, glycerol, water when softgel shell is made;
Ginkgo leaf soft capsule of the present invention, preferred component is: the weight ratio of Folium Ginkgo volatile oil and vegetable oil is 2: 1 in the medicinal liquid; The weight proportion 1: 0.2: 0.8 of gelatin, glycerol, water when softgel shell is made; Vegetable oil is a Semen Maydis oil.
The extracting method of Folium Ginkgo volatile oil is among the present invention: " method that Chinese pharmacopoeia is an one was extracted volatile oil with steam distillation, and extraction time 6h gets the pale yellow oily liquid body with reference to version in 2000.Yield is 0.15%.
The manufacture method of ginkgo leaf soft capsule of the present invention is that Folium Ginkgo volatile oil is joined in the vegetable oil, after at room temperature fully stirring, on the soft capsule press, suppress, again through clean, dry and soft capsule.
The method for making of softgel shell is: gelatin is added in the rustless steel glue pot, add suitable quantity of water again, airtight, 70 ℃ are incubated 3 hours, add an amount of glycerol again, stir, and vacuumize degassing 2 hours is put into 70 ℃ of insulations of gelatin bucket standing over night, uses for the preparation soft capsule shell.
Good effect of the present invention is that pharmacological testing embodiment shows that ginkgo leaf soft capsule provided by the present invention has cardiovascular, anti-hypoxia isoreactivity, and is easy to take, and helps the absorption of patient to medicine.
The specific embodiment
The invention will be further described with embodiment below, but the present invention is not construed as limiting.
Embodiment 1 ginkgo leaf soft capsule and preparation method thereof
Get Folium Ginkgo volatile oil 400g and join in the 100g soybean oil, stir at ambient temperature, make medicinal liquid.Get gelatin 200g, glycerol 66g and water 180g by weight 1: 0.33: 0.9, make the capsule material.
Above-mentioned medicinal liquid and capsule material are pressed into 1000 Folium Ginkgo volatile oil soft capsules on the soft capsule press.
Embodiment 2 ginkgo leaf soft capsules and preparation method thereof
Get Folium Ginkgo volatile oil 50g and join in the 100g Oleum Arachidis hypogaeae semen, stir at ambient temperature, make medicinal liquid.Get gelatin 200g, glycerol 100g and water 220g by weight 1: 0.5: 1.1, make the capsule material.
Above-mentioned medicinal liquid and capsule material are pressed into 1000 Folium Ginkgo volatile oil soft capsules on the soft capsule press.
Embodiment 3 ginkgo leaf soft capsules and preparation method thereof
Get Folium Ginkgo volatile oil 200g and join in the 100g Oleum Camelliae, stir at ambient temperature, make medicinal liquid.Get gelatin 200g, glycerol 40g and water 160g by weight 1: 0.2: 0.8, make the capsule material.
Above-mentioned medicinal liquid and capsule material are pressed into 1000 Folium Ginkgo volatile oil soft capsules on the soft capsule press.
Embodiment 4 ginkgo leaf soft capsules and preparation method thereof
Get Folium Ginkgo volatile oil 100g and join in the 400g Semen Maydis oil, stir at ambient temperature, make medicinal liquid.Get gelatin 200g, glycerol 80g and water 260g by weight 1: 0.4: 1.3, make the capsule material.
Above-mentioned medicinal liquid and capsule material are pressed into 1000 Folium Ginkgo volatile oil soft capsules on the soft capsule press.
Experimental example 1 Folium Ginkgo volatile oil is to the test of anti-hypoxia under the mice normal pressure
40 of healthy mices, 20 ± 2g, male and female half and half are divided 4 groups at random, continuous 10 days of gastric infusion.With bell jar process hypoxia endurance test observed and recorded mouse diing time, mice goes into the preceding all subcutaneous injection isoproterenol 0.2mg/kg of pin cover, and continuous 10 days of gastric infusion is observed mouse diing time and survival rate after drug withdrawal, the results are shown in following table:
| Group | Dose mg/kg | Survival rate % |
| The blank group | ???- | ??0 |
| The Folium Ginkgo volatile oil high dose group | ???400 | ??85 |
| Dosage group in the Folium Ginkgo volatile oil | ???200 | ??60 |
| The Folium Ginkgo volatile oil low dose group | ???100 | ??25 |
As seen from the above table, Folium Ginkgo volatile oil can obviously prolong the mice time-to-live under the condition of normal pressure, improves survival rate.
The test that resists myocardial ischemia of experimental example 2 Folium Ginkgo volatile oil
The adult healthy domestic cat, 10 of body weight 2.5～3.0Kg, pentobarbital sodium 30mg/kg administration, ip anesthesia, tracheal intubation connects electric pulmotor pedestrian worker and breathes, left side the 4th intercostal is opened breast, exposes heart, cuts off pericardium, make the pericardium bed, separate left anterior descending coronary artery, at the first branch stage casing underpass, ligation coronary artery.Open abdomen,, press the 4g/kg administration by duodenal intubation, win heart after 3 hours rapidly, normal saline flushing is parallel to coronary sulcus and equably the ventricle crosscut is become 5 below ligature, put in the N-BT dye liquor and dye, measure the every myocardium gross area and infarct area with planimeter.
| Group | Infarct/heart (%) | Infarct/ventricle (%) |
| The blank group | ??25.3±3.2 | ??40.6±5.2 |
| The Folium Ginkgo volatile oil group | ??15.2±3.6* | ??23.5±4.1* |
Compare * P＜0.01 with the blank group
The result shows that Folium Ginkgo volatile oil can obviously dwindle myocardial infarction area, compares with the blank group, and significant difference (P＜0.01) shows that Folium Ginkgo volatile oil has protective effect to the cat acute myocardial infarction.
Claims (4)
1, a kind of ginkgo leaf soft capsule is sealed the medicinal liquid that contains following composition: Folium Ginkgo volatile oil and vegetable oil in soft capsule shell.
2, ginkgo leaf soft capsule according to claim 1 is characterized in that:
The weight ratio of Folium Ginkgo volatile oil and vegetable oil is: 1: 4～4: 1;
The weight proportion 1: 02～0.5 of gelatin, glycerol, water when softgel shell is made: .7～1.3;
Vegetable oil is selected from a kind of or wherein several mixture in soybean oil, Semen Maydis oil, Oleum Arachidis hypogaeae semen, the Oleum Camelliae.
3, ginkgo leaf soft capsule according to claim 2 is characterized in that:
The weight ratio of Folium Ginkgo volatile oil and vegetable oil is 2: 1;
The weight proportion 1: 0.2: 0.8 of gelatin, glycerol, water when softgel shell is made;
Vegetable oil is a Semen Maydis oil.
4, the preparation method of ginkgo leaf soft capsule as claimed in claim 1 may further comprise the steps: Folium Ginkgo volatile oil is joined in the vegetable oil, after at room temperature fully stirring, on the soft capsule press, suppresses, again through clean, dry and soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510033392 CN1682884A (en) | 2005-03-03 | 2005-03-03 | Ginkgo leaf soft capsule and its preparing method |
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| CN 200510033392 CN1682884A (en) | 2005-03-03 | 2005-03-03 | Ginkgo leaf soft capsule and its preparing method |
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| CN 200510033392 Pending CN1682884A (en) | 2005-03-03 | 2005-03-03 | Ginkgo leaf soft capsule and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637481B (en) * | 2009-08-05 | 2012-07-11 | 北京双鹤高科天然药物有限责任公司 | Prescription of gingkgo leaf soft capsule and preparation method thereof |
| CN104127580A (en) * | 2014-06-30 | 2014-11-05 | 江苏伟楼生物科技有限公司 | Ginkgo softgel and preparation method thereof |
| CN109432042A (en) * | 2018-12-24 | 2019-03-08 | 石药集团恩必普药业有限公司 | A kind of soft capsule shell and preparation method thereof |
-
2005
- 2005-03-03 CN CN 200510033392 patent/CN1682884A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637481B (en) * | 2009-08-05 | 2012-07-11 | 北京双鹤高科天然药物有限责任公司 | Prescription of gingkgo leaf soft capsule and preparation method thereof |
| CN104127580A (en) * | 2014-06-30 | 2014-11-05 | 江苏伟楼生物科技有限公司 | Ginkgo softgel and preparation method thereof |
| CN109432042A (en) * | 2018-12-24 | 2019-03-08 | 石药集团恩必普药业有限公司 | A kind of soft capsule shell and preparation method thereof |
| CN109432042B (en) * | 2018-12-24 | 2022-04-22 | 石药集团恩必普药业有限公司 | Soft capsule shell and preparation method thereof |
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