CN104127580A - Ginkgo softgel and preparation method thereof - Google Patents
Ginkgo softgel and preparation method thereof Download PDFInfo
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- CN104127580A CN104127580A CN201410307926.5A CN201410307926A CN104127580A CN 104127580 A CN104127580 A CN 104127580A CN 201410307926 A CN201410307926 A CN 201410307926A CN 104127580 A CN104127580 A CN 104127580A
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Abstract
The invention discloses a ginkgo softgel and a preparation method thereof. The ginkgo softgel consists of a medicine liquid and a capsule casing. The medicine liquid is composed of the following raw materials in parts by weight: 90-100 parts of ginkgo extractive, 60-70 parts of soybean oil and 50-60 parts of camellia oil. The capsule casing is composed of the following raw materials: gelatin, glycerin, purified water and an antiseptic with the ratio of 1:3:1:0.001. By adding camellia oil with a certain ratio into the medicine liquid, multiple nutrient element compositions are added into the ginkgo capsule, so that the ginkgo softgel has conventional effects of adjusting blood fat and blood pressure and improving brain functions, and also is capable of further providing comprehensive amino acids and vitamins for a user and enabling nutrition to be relatively comprehensive.
Description
Technical field
The present invention relates to a kind of soft capsule and preparation method thereof, specifically a kind of Semen Ginkgo soft capsule and preparation method thereof, belongs to health care medicine technical field.
Background technology
After soft capsule picked-up, content discharges rapidly, and in body, utilization rate and absorbance are all higher, therefore first-selected as packaging by health care medicine gradually.Semen Ginkgo soft capsule is rich in Folium Ginkgo extract, not only remarkable to " three-hypers " crowd effect, can regulate blood fat, vessel softening, reduce blood pressure, and can improve brain function, alleviates the symptoms such as headache, tinnitus, dizzy, forgetful, dreaminess; Can memory reinforcing, prevention senile dementia; Contain anti-platelet activating factor, can remove cancerigenic factor; But the main nutrient composition in Semen Ginkgo soft capsule is ginkgo flavonoid glycoside and Folium Ginkgo terpene lactones, ginkgo flavonoid glycoside has been proved and can have effectively resisted and eliminate free radical, and plays the good action of slow down aging; Semen Ginkgo is covered lactone with mat and optionally resists platelet activating factor, platelet activating factor is a kind of very strong caused platelet aggregation and thrombosed endogenous active substance in human body, to bring out the remorse disease of cardiovascular and cerebrovascular vessel, particularly cause the stealthy killer of apoplexy, myocardial infarction, danger is very high, and ginkgolide is the jinx of platelet activating factor.But the aminoacid in Semen Ginkgo soft capsule and micronutrient levels are very low, therefore cannot meet the full nutrition needs of human body.
Summary of the invention
The problem existing for above-mentioned prior art, the invention provides a kind of Semen Ginkgo soft capsule and preparation method thereof, this capsule not only has the health-care effect of traditional Semen Ginkgo soft capsule, and is rich in aminoacid and the trace element of needed by human body, can meet the full nutrition demand of human body.
To achieve these goals, the invention provides a kind of Semen Ginkgo soft capsule, be made up of medicinal liquid and softgel shell, described medicinal liquid is made up of the raw material of following parts by weight: 90 parts-100 parts of Folium Ginkgo extract, soybean oil 60-70 part, Camellia oil 50-60 part; Described softgel shell is made up of the raw material of following weight proportion: gelatin: glycerol: purified water: the ratio of antiseptic is 1: 3: 1: 0.001.
The preparation method of above-mentioned Semen Ginkgo soft capsule, concrete steps are:
(1) batching
Take soybean oil and Camellia oil according to described parts by weight, mix homogeneously, adds the Folium Ginkgo extract taking in soybean oil and Camellia oil, stirs, and makes described medicinal liquid;
(2) colloidal sol
Antiseptic is dissolved in the ethanol of 2 times of amounts, gelatin, glycerol and purified water in proportion in joining glue tank, are heated with stirring to 60 DEG C-70 DEG C, add antiseptic alcoholic solution under continuous stirring, mix homogeneously, makes glue;
(3) pelleting
The above-mentioned medicinal liquid making and glue are passed through to pellet press pelleting, drop into subsequently rotating cage drying machine and shape dry;
(4) wash ball
Soft gelatin capsule is cleaned with ultrasonic washing unit, cleaning solvent is 95% ethanol;
(5) ball that dries in the air
Soft gelatin capsule is placed in to the dish that dries in the air, and controlling the temperature of drying in the air between ball is 22 DEG C-28 DEG C, makes 95% ethanol volatilization completely;
(6) choose ball
Soft gelatin capsule tiling is placed on lamp inspection desk, defective soft gelatin capsule is sorted out;
(7) packaging
The soft gelatin capsule of picking out is packed.
Preferably, described antiseptic is methyl parahydroxybenzoate, is widely used in the anticorrosion and bactericidal agent of medicament, because it has phenolic hydroxyl structure, so antibacterium performance is all stronger than benzoic acid, sorbic acid.
The invention has the beneficial effects as follows: by add a certain proportion of Camellia oil in medicinal liquid, for Gingkocapsule adds various nutrient elements composition, (unsaturated fatty acid is about 93% to Camellia oil fatty acids, wherein oleic acid 82%, linoleic acid 11%), camellianin, tea polyphenols, Saponin, tannin, and be rich in antioxidant and there is the Squalene of anti-inflammatory effect, Camellia oil is the trace element such as rich in vitamin E and calcium, ferrum, zinc also, wherein zinc content is ten times of soybean oil, and in Camellia oil, amino acid contained kind is maximum in all edible oil; Make Semen Ginkgo soft capsule not only there is traditional adjusting blood fat, blood pressure and improve the effect of brain function, and can be further for user provides comprehensive aminoacid and vitamin, nutrition is more comprehensive.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
A kind of Semen Ginkgo soft capsule, is made up of medicinal liquid and softgel shell, and described medicinal liquid is made up of the raw material of following parts by weight: 90 parts of Folium Ginkgo extract, 60 parts of soybean oils, 50 parts of Camellia oil; Described softgel shell is made up of the raw material of following weight proportion: gelatin: glycerol: purified water: the ratio of methyl parahydroxybenzoate is 1: 3: 1: 0.001.
A preparation method for Semen Ginkgo soft capsule, concrete steps are:
(1) batching
Take soybean oil and Camellia oil according to described parts by weight, mix homogeneously, adds the Folium Ginkgo extract taking in soybean oil and Camellia oil, stirs, and makes described medicinal liquid;
(2) colloidal sol
Antiseptic is dissolved in the ethanol of 2 times of amounts, gelatin, glycerol and purified water in proportion in joining glue tank, are heated with stirring to 65 DEG C, add antiseptic alcoholic solution under continuous stirring, mix homogeneously, makes glue;
(3) pelleting
The above-mentioned medicinal liquid making and glue are passed through to pellet press pelleting, drop into subsequently rotating cage drying machine and shape dry;
(4) wash ball
Soft gelatin capsule is cleaned with ultrasonic washing unit, cleaning solvent is 95% ethanol;
(5) ball that dries in the air
Soft gelatin capsule is placed in to the dish that dries in the air, and controlling the temperature of drying in the air between ball is 25 DEG C, makes 95% ethanol volatilization completely;
(6) choose ball
Soft gelatin capsule tiling is placed on lamp inspection desk, defective soft gelatin capsule is sorted out;
(7) packaging
The soft gelatin capsule of picking out is packed.
By the Semen Ginkgo soft capsule of producing by batch detecting, extract the Semen Ginkgo soft capsule that three different batches are produced, inspect 50 by random samples for each batch, detect the content of calcium, ferrum, zinc, vitamin E and tea polyphenols wherein, then average, testing result is as shown in table 1.
The testing result of table 1 embodiment 1
| Test item | Average content |
| Calcium | 9.78μg/g |
| Ferrum | 2.50μg/g |
| Zinc | 5.32μg/g |
| Vitamin E | 108.25μg/g |
| Tea polyphenols | 70.14μg/g |
As can be seen from Table 1, the Semen Ginkgo soft capsule that the present invention produces contains the trace element such as abundant vitamin E and calcium, ferrum, zinc, but also contains tea polyphenols, effectively prevention and cure of cardiovascular disease, and the nutrition of general equilibrium more can be provided.
Embodiment 2
A kind of Semen Ginkgo soft capsule, is made up of medicinal liquid and softgel shell, and described medicinal liquid is made up of the raw material of following parts by weight: 100 parts of Folium Ginkgo extract, 70 parts of soybean oils, 60 parts of Camellia oil; Described softgel shell is made up of the raw material of following weight proportion: gelatin: glycerol: purified water: the ratio of methyl parahydroxybenzoate is 1: 3: 1: 0.001.
A kind of Semen Ginkgo soft capsule, the concrete steps of preparation method are:
(1) batching
Take soybean oil and Camellia oil according to described parts by weight, mix homogeneously, adds the Folium Ginkgo extract taking in soybean oil and Camellia oil, stirs, and makes described medicinal liquid;
(2) colloidal sol
Antiseptic is dissolved in the ethanol of 2 times of amounts, gelatin, glycerol and purified water in proportion in joining glue tank, are heated with stirring to 60 DEG C, add antiseptic alcoholic solution under continuous stirring, mix homogeneously, makes glue;
(3) pelleting
The above-mentioned medicinal liquid making and glue are passed through to pellet press pelleting, drop into subsequently rotating cage drying machine and shape dry;
(4) wash ball
Soft gelatin capsule is cleaned with ultrasonic washing unit, cleaning solvent is 95% ethanol;
(5) ball that dries in the air
Soft gelatin capsule is placed in to the dish that dries in the air, and controlling the temperature of drying in the air between ball is 26 DEG C, makes 95% ethanol volatilization completely;
(6) choose ball
Soft gelatin capsule tiling is placed on lamp inspection desk, defective soft gelatin capsule is sorted out;
(7) packaging
The soft gelatin capsule of picking out is packed.
By the Semen Ginkgo soft capsule of producing by batch detecting, extract the Semen Ginkgo soft capsule that three different batches are produced, inspect 50 by random samples for each batch, detect the content of calcium, ferrum, zinc, vitamin E and tea polyphenols wherein, then average, testing result is as shown in table 2.
The testing result of table 2 embodiment 2
| Test item | Average content |
| Calcium | 9.57μg/g |
| Ferrum | 2.73μg/g |
| Zinc | 5.66μg/g |
| Vitamin E | 108.08μg/g |
| Tea polyphenols | 70.31μg/g |
Detection data and table 1 in table 2 are compared, the content fluctuation of finding calcium, ferrum, zinc, vitamin E and tea polyphenols is little, illustrate by adding in medicinal liquid after a certain proportion of Camellia oil, make the Semen Ginkgo soft capsule can be further for user provides various trace elements, vitamin E and tea polyphenols, nutrition be more comprehensive.
Claims (3)
1. a Semen Ginkgo soft capsule, is made up of medicinal liquid and softgel shell, it is characterized in that, described medicinal liquid is made up of the raw material of following parts by weight: 90 parts-100 parts of Folium Ginkgo extract, soybean oil 60-70 part, Camellia oil 50-60 part; Described softgel shell is made up of the raw material of following weight proportion: gelatin: glycerol: purified water: the ratio of antiseptic is 1: 3: 1: 0.001.
2. a preparation method for Semen Ginkgo soft capsule, is characterized in that, concrete steps are:
(1) batching
Take soybean oil and Camellia oil according to described parts by weight, mix homogeneously, adds the Folium Ginkgo extract taking in soybean oil and Camellia oil, stirs, and makes described medicinal liquid;
(2) colloidal sol
Antiseptic is dissolved in the ethanol of 2 times of amounts, gelatin, glycerol and purified water in proportion in joining glue tank, are heated with stirring to 60 DEG C-70 DEG C, add antiseptic alcoholic solution under continuous stirring, mix homogeneously, makes glue;
(3) pelleting
The above-mentioned medicinal liquid making and glue are passed through to pellet press pelleting, drop into subsequently rotating cage drying machine and shape dry;
(4) wash ball
Soft gelatin capsule is cleaned with ultrasonic washing unit, cleaning solvent is 95% ethanol;
(5) ball that dries in the air
Soft gelatin capsule is placed in to the dish that dries in the air, and controlling the temperature of drying in the air between ball is 22 DEG C-28 DEG C, makes 95% ethanol volatilization completely;
(6) choose ball
Soft gelatin capsule tiling is placed on lamp inspection desk, defective soft gelatin capsule is sorted out;
(7) packaging
The soft gelatin capsule of picking out is packed.
3. a kind of Semen Ginkgo soft capsule according to claim 1, is characterized in that, described antiseptic is methyl parahydroxybenzoate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410307926.5A CN104127580A (en) | 2014-06-30 | 2014-06-30 | Ginkgo softgel and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410307926.5A CN104127580A (en) | 2014-06-30 | 2014-06-30 | Ginkgo softgel and preparation method thereof |
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| CN201410307926.5A Pending CN104127580A (en) | 2014-06-30 | 2014-06-30 | Ginkgo softgel and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272832A (en) * | 2018-04-10 | 2018-07-13 | 辽宁仙草堂药业有限公司 | A kind of ginkgo leaf soft capsule and preparation method thereof |
| CN112450438A (en) * | 2020-11-13 | 2021-03-09 | 南昌大学 | Camellia oil soft capsule, preparation method and application thereof |
| CN113577038A (en) * | 2021-09-01 | 2021-11-02 | 山东森健生物科技发展有限公司 | Ginkgo leaf soft capsule |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682884A (en) * | 2005-03-03 | 2005-10-19 | 深圳海王药业有限公司 | Ginkgo leaf soft capsule and its preparing method |
| CN101637481A (en) * | 2009-08-05 | 2010-02-03 | 北京双鹤高科天然药物有限责任公司 | Prescription of gingkgo leaf soft capsule and preparation method thereof |
| CN102138968A (en) * | 2010-02-03 | 2011-08-03 | 博辉生物药业(深圳)有限公司 | Soft capsule containing natto and gingko |
-
2014
- 2014-06-30 CN CN201410307926.5A patent/CN104127580A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682884A (en) * | 2005-03-03 | 2005-10-19 | 深圳海王药业有限公司 | Ginkgo leaf soft capsule and its preparing method |
| CN101637481A (en) * | 2009-08-05 | 2010-02-03 | 北京双鹤高科天然药物有限责任公司 | Prescription of gingkgo leaf soft capsule and preparation method thereof |
| CN102138968A (en) * | 2010-02-03 | 2011-08-03 | 博辉生物药业(深圳)有限公司 | Soft capsule containing natto and gingko |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272832A (en) * | 2018-04-10 | 2018-07-13 | 辽宁仙草堂药业有限公司 | A kind of ginkgo leaf soft capsule and preparation method thereof |
| CN112450438A (en) * | 2020-11-13 | 2021-03-09 | 南昌大学 | Camellia oil soft capsule, preparation method and application thereof |
| CN113577038A (en) * | 2021-09-01 | 2021-11-02 | 山东森健生物科技发展有限公司 | Ginkgo leaf soft capsule |
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