CN101637481A - Prescription of gingkgo leaf soft capsule and preparation method thereof - Google Patents

Prescription of gingkgo leaf soft capsule and preparation method thereof Download PDF

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Publication number
CN101637481A
CN101637481A CN200910162437A CN200910162437A CN101637481A CN 101637481 A CN101637481 A CN 101637481A CN 200910162437 A CN200910162437 A CN 200910162437A CN 200910162437 A CN200910162437 A CN 200910162437A CN 101637481 A CN101637481 A CN 101637481A
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Prior art keywords
soft capsule
preparation
soybean lecithin
softgel shell
folium ginkgo
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CN200910162437A
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CN101637481B (en
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(请求不公开姓名)
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Beijing Huarun Gaoke Natural Medicine Co., Ltd.
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SHUANGHE HIGH-TECH NATURAL MEDICINE Co Ltd BEIJING
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Abstract

The invention discloses a prescription of a gingkgo leaf soft capsule and a preparation method thereof. The soft capsule consists of two parts of liquid medicine and a softgel shell, wherein the liquid medicine contains gingkgo leaf extract and soya bean lecithin, and the weight percent of the gingkgo leaf extract and the soya bean lecithin is 1:8-2:1. The softgel shell is made by using gelatin, glycerin and water with the weight percent of 1:(0.3-0.6):(0.6-1.2); and the soft capsule is made by the confected liquid medicine and softgel shell with a pressing method for preventing and treating cerebrovascular disease, and the like. The invention has the advantages of simple technique, scientific prescription, convenient operation and low cost.

Description

Prescription of ginkgo leaf soft capsule and preparation method thereof
Technical field
The present invention relates to a kind of prescription and preparation technology thereof of ginkgo leaf soft capsule
Background technology
Semen Ginkgo has very long medicinal in China, edible history have the title of living fossil.According to " Treatise on Dietetic Therapy " record, its can be used for cardiopalmus seized with terror in, diseases such as cough and asthma due to lung deficiency.Contain flavone compound in the modern medicine study proof Folium Ginkgo, bioactive ingredients such as terpenoid, these compositions have quite intensive antioxidation, can remove free radical superfluous in the organism, stop the body lipid peroxidating, improve the immunity of body etc.Its flavones ingredient, the energy coronary dilating; Improve the heart, cerebral blood circulation reduces serum cholesterol, also has high antiallergic, shock, and effects such as anti-organ transplant rejection are the natural drugs of the treatment cardiovascular and cerebrovascular disease of first-selection.
Lecithin can emulsifying, cut grease, and can will change into micropartical attached to cholesterol on the blood vessel wall and fat milk, makes it to be dissolved in to transport liver in the blood back and by metabolism.Play vessel softening, improve serum lipids, remove the effect of peroxide, make cholesterol and fat content reduction in the blood, thereby reduce the blood stickiness, promote blood circulation, reduce fat in the endovascular holdup time.And then, make nutritious, contain the competent blood of oxygen, flow to organs such as brain, heart unblockedly.Clinical experiment was once done by medical college food nutrition system of Japan keio university, and reach a conclusion: by taking lecithin, can effectively reduce too high blood fat and cholesterol, and then prevent and treat diseases such as coronary heart disease, hypertension, myocardial infarction, cerebral thrombosis, cerebral hemorrhage, arteriosclerosis.
The various dosage forms of ginkgo agent medicine and health product all are subjected to the welcome in market, and tablet, injection become the leading dosage form in preparation market, and capsule, drop pill have also been showed good development potentiality.Soft capsule is a most popular peroral dosage form in the world today, with respect to dosage forms such as tablet and hard capsules, has removed disintegrate in the body from, disperses, and the process of stripping makes the easier stripping of effective ingredient; With respect to injection, characteristics such as easy to carry, safe in utilization are arranged.Soft capsule can overcome the shortcoming of existing dosage form, and steady quality is arranged, and carries taking convenience, but advantage such as the outward appearance impression is strong, and is safe in utilization.
Chinese patent 200410087855.9,200510002416.8,200510033392.2 three patents all disclose a kind of conventional way of ginkgo leaf soft capsule, but these three kinds of methods all are that Folium Ginkgo extract is simply made this dosage form of soft capsule, and Chinese patent 200710195092.3 discloses the health product compounds of forming with lecithin and Folium Ginkgo extract, but also is to have made up lecithin and Folium Ginkgo extract simply.The present invention is dissolved the content medicinal liquid of Folium Ginkgo extract as soft capsule with soybean lecithin, get final product so that capsular quality is improved, it is bad to have solved the Folium Ginkgo extract dissolubility again, the problem that bioavailability is not high, simultaneously, soybean lecithin itself just has the pharmacological action of blood lipid regulation, and it is that the pharmacy worker pursues that the medication adjuvant can play effect collaborative or the enhancing therapeutic effect to principal agent always.
The present invention has overcome the deficiencies in the prior art, is primary raw material with Folium Ginkgo extract and soybean lecithin, has developed a kind of preparation of soft capsule method of preventing and treating cardiovascular and cerebrovascular disease.
Summary of the invention
The object of the invention provides a kind of dissolubility and bioavailability that improves Folium Ginkgo extract, strengthens prescription of the soft capsule of preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof.
The present invention treats the cardiovascular and cerebrovascular vessel soft capsule with Folium Ginkgo extract, and soybean lecithin is that primary raw material is made.
Technical scheme of the present invention is, make medicinal liquid in the capsule softgel shell with soybean lecithin dissolving Folium Ginkgo extract, the weight ratio of Folium Ginkgo extract and soybean lecithin is in the medicinal liquid: 1: 8~2: 1, use gelatin, glycerol during the making of softgel shell, the weight proportion of water 1: 0.3~0.6: 0.6~1.2, can when the making of medicinal liquid and softgel shell, add diluent, suspending agent, surfactant, antiseptic, one or more in the antioxidant.
Ginkgo leaf soft capsule of the present invention, preferred component is: the weight ratio of Folium Ginkgo extract and soybean lecithin is: 1: 3; When making, softgel shell uses gelatin, glycerol, the weight proportion of water 1: 0.4: 0.9.
The manufacture method of ginkgo leaf soft capsule of the present invention is that Folium Ginkgo extract is added in the soybean lecithin, after at room temperature fully stirring, on the soft capsule press, suppress, again through cleaning, dry and soft capsule.
The method for making of softgel shell is: gelatin added in the Stainless Steel glue pot, adds suitable quantity of water again, and sealing, 70 ℃ are incubated 3 hours, add an amount of glycerol again, and vacuumize degassing 2 hours is put into 70 ℃ of insulations of gelatin bucket standing over night, uses for the preparation soft capsule.
The specific embodiment
Case study on implementation 1
Form umber (by weight)
1 part of Folium Ginkgo extract
3 parts of soybean lecithins
2 parts of glycerol
5 parts in gelatin
The preparation of softgel shell: get 5 parts in gelatin, add while stirring in 4.25 parts of water, 70 ℃ are incubated 3 hours, and the dissolving back adds 2 parts of glycerol fully, stirs, and vacuumize degassing, 70 ℃ are incubated standing over night, stand-by.
Softgel shell content medicinal liquid and capsular preparation, get 1 part of Folium Ginkgo extract (crossing 100 mesh sieves), with 3 parts soybean lecithin dissolvings wherein, stir, vacuumize degassing, remain at content and to be higher than 40 ℃, 37 ℃-50 ℃ of control sprinkler body temperature, colloid temperature are controlled at pelleting under 55 ℃-65 ℃ the condition, again through qualitative drying, wash ball, the ball operation of drying in the air, promptly.
Case study on implementation 2
Form umber (by weight)
1 part of Folium Ginkgo extract
5.8 parts of soybean lecithins
2.2 parts of glycerol
4.3 parts in gelatin
The preparation of softgel shell: get 4.3 parts in gelatin, add while stirring in 3.8 parts of water, 70 ℃ are incubated 3 hours, and the dissolving back adds 2.2 parts of glycerol fully, stirs, and vacuumize degassing, 70 ℃ are incubated standing over night, stand-by.
Softgel shell content medicinal liquid and capsular preparation, get 1 part of Folium Ginkgo extract (crossing 100 mesh sieves), with 5.8 parts soybean lecithin dissolvings wherein, stir, vacuumize degassing, remain at content and to be higher than 40 ℃, 37 ℃-50 ℃ of control sprinkler body temperature, colloid temperature are controlled at pelleting under 55 ℃-65 ℃ the condition, again through qualitative drying, wash ball, the ball operation of drying in the air, promptly.
Case study on implementation 3
Form umber (by weight)
1 part of Folium Ginkgo extract
4.2 parts of soybean lecithins
1.8 parts of glycerol
3.8 parts in gelatin
0.01 part of sorbic acid methyl ester
0.03 part of mud moor gold ethyl ester
The preparation of softgel shell: get 3.8 parts in gelatin, add while stirring in 3.5 parts of water, 70 ℃ are incubated 3 hours, and the dissolving back adds 1.8 parts of glycerol fully, and 0.01 part of sorbic acid methyl ester stirs, vacuumize degassing, and 70 ℃ are incubated standing over night, stand-by.
1 part of Folium Ginkgo extract (crossing 100 mesh sieves) is got in softgel shell content medicinal liquid and capsular preparation, with 4.2 parts soybean lecithin dissolvings wherein, stir, get 0.03 part of mud moor gold ethyl ester again, stir, vacuumize degassing, remain at content and to be higher than 40 ℃, 37 ℃-50 ℃ of control sprinkler body temperature, colloid temperature are controlled at pelleting under 55 ℃-65 ℃ the condition, again through qualitative drying, wash ball, the ball operation of drying in the air, promptly.

Claims (5)

1 one kinds of Semen Ginkgo soft capsules comprise the medicinal liquid of following composition: Folium Ginkgo extract and soybean lecithin in soft capsule shell.
2 ginkgo leaf soft capsules according to claim 1 is characterized in that:
The weight ratio of Folium Ginkgo extract and soybean lecithin is: 1: 8 ~ 2: 1;
When making, softgel shell uses gelatin, glycerol, the weight proportion of water 1: 0.3 ~ 0.6: 0.6 ~ 1.2.
3 is characterized in that adding adjuvant according to claim 1 and 2 described ginkgo leaf soft capsules: its classification can be diluent, suspending agent, surfactant, antiseptic, one or more in the antioxidant.
4 ginkgo leaf soft capsules according to claim 2 is characterized in that:
The weight ratio of Folium Ginkgo extract and soybean lecithin is: 1: 3;
When making, softgel shell uses gelatin, glycerol, the weight proportion of water 1: 0.4: 0.9.
The preparation method of 5 ginkgo leaf soft capsules as claimed in claim 1 may further comprise the steps: Folium Ginkgo extract joined in the soybean lecithin, after at room temperature fully stirring, on the soft capsule press, suppresses, and again through cleaning, dry and obtain soft capsule.
CN2009101624374A 2009-08-05 2009-08-05 Prescription of gingkgo leaf soft capsule and preparation method thereof Active CN101637481B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104127580A (en) * 2014-06-30 2014-11-05 江苏伟楼生物科技有限公司 Ginkgo softgel and preparation method thereof
CN111249445A (en) * 2020-02-27 2020-06-09 广东医科大学 Cytochalasin H soft capsule and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1221266C (en) * 2001-11-22 2005-10-05 中国科学院地理科学与资源研究所 Compound prepn containing alpha-linolic acid, lecithin and ginkgetin
CN1634428A (en) * 2004-11-01 2005-07-06 辽宁大生药业有限公司 Ginkgo leaf soft capsule and preparation technique thereof
CN1682884A (en) * 2005-03-03 2005-10-19 深圳海王药业有限公司 Ginkgo leaf soft capsule and its preparing method
CN101224260A (en) * 2006-12-13 2008-07-23 天津市弗兰德医药科技发展有限公司 Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104127580A (en) * 2014-06-30 2014-11-05 江苏伟楼生物科技有限公司 Ginkgo softgel and preparation method thereof
CN111249445A (en) * 2020-02-27 2020-06-09 广东医科大学 Cytochalasin H soft capsule and preparation method thereof
CN111249445B (en) * 2020-02-27 2022-11-15 广东医科大学 Cytochalasin H soft capsule and preparation method thereof

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Owner name: BEIJING HUARUN HIGH-TECH NATURAL PHARMACEUTICAL CO

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Address after: Yanqing Town, Beijing city Yanqing County 102100 Guishui No. 11 South Street

Patentee after: Beijing Huarun Gaoke Natural Medicine Co., Ltd.

Address before: Yanqing Town, Beijing city Yanqing County 102100 Guishui No. 11 South Street

Patentee before: Shuanghe High-Tech. Natural Medicine Co., Ltd., Beijing