CN102138968A - Soft capsule containing natto and gingko - Google Patents
Soft capsule containing natto and gingko Download PDFInfo
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- CN102138968A CN102138968A CN2010101051746A CN201010105174A CN102138968A CN 102138968 A CN102138968 A CN 102138968A CN 2010101051746 A CN2010101051746 A CN 2010101051746A CN 201010105174 A CN201010105174 A CN 201010105174A CN 102138968 A CN102138968 A CN 102138968A
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Abstract
The invention discloses a formula composition of a soft capsule containing natto and gingko and a preparation method thereof. 100mg of natto extract, 60mg of ginkgo leaf extract and 40mg of salvia miltiorrhiza extract, together with soybean oil, beewax and a rubber sheet are prepared into 500mg per granule of soft capsule. The natto extract, the ginkgo leaf extract and the salvia miltiorrhiza extract based on the formula are prepared, mixed, subpackaged, externally packaged, inspected, put in storage and stored strictly according to the procedure after the quality inspection of raw materials and auxiliary materials is qualified. The soft capsule is suitable for the fields of food, medicines, and healthcare products, and is used for losing weight, beautifying the appearance, and improving a cardiovascular system.
Description
Technical field
The prescription that the invention discloses natto Semen Ginkgo soft capsule is formed and preparation method thereof.Natto extract and Folium Ginkgo extract are the primary raw material of this product.Natto extract---nattokinase can thrombus, blood pressure lowering, blood fat reducing, blood sugar lowering, Antialcoholic liver-protecting, improve effects such as function of intestinal canal loosening bowel to relieve constipation, eliminating toxin and beautifying the skin, so be widely used in the various cardiovascular and cerebrovascular diseases of treatment prevention, as: heart infarction, cerebral infarction, hypertension, hyperlipidemia, fat-reducing, beauty treatment etc.Folium Ginkgo extract promotes big cerebral blood flow and nervous system is had fabulous tonic effect, can promote the circulation of brain and health limbs simultaneously.From raw-materially choose, prescription, Technology aspect all obtained system verification, Zhi Bei natto Semen Ginkgo soft capsule has the function of reducing weight and beautifying features and protection cardiovascular system thus, is applicable to health care and field of pharmaceutical preparations.
Background technology
1987, must see that the professor of foreign firm waits to extract nattokinase from natto (nattokinase NK), and proves that it has intensive thrombus ability, causes the interest of people to the natto product.The wet natto thrombolytic effect of every gram is equivalent to urokinase 160OFU, non-inactivation in gastrointestinal.Nattokinase is compared with urokinase the long action time of thrombosis 3～5 minute action time, and the nattokinase effect reaches 8 hours, and safely, have no side effect.Behind the edible natto, thrombosed material can slowly reduce in the mensuration blood, and thrombolytic material can get more and more, and reaches dynamic equilibrium.Often eat natto and also the thromboembolism in the blood capillary can be fallen, effectively the microcirculation improvement obstacle.
After nattokinase enters human body, make up the ethanol protective barriers: enter the human liver system, decompose the liver pressure that relieves the effect of alcohol, assist to relieve the effect of alcohol by triple channels; Enter the human blood circulatory system, form the key protection barrier, resist the depression effect of ethanol brain in the cerebrovascular zone; Enter the human body alimentary canal system, form the protection barrier rapidly, quicken the digestive tract acidic secretion, promote to relieve the effect of alcohol.Take natto and can solve untoward reaction after drinking such as headache, vomiting, regurgitation, xerostomia tongue hardship, tired evil, sensation of oppression over the chest with shortness of breath, of short duration memory loss, visual deterioration, audition rapidly and weaken etc., and liquor-saturated can prevent the next day.In addition, the various active material activating liver cell in the natto promotes liver cell regeneration, improves liver function, the liver protecting, and effectively prevention improves fatty liver.So at the widely popular proverb of Japan: " eat when drinking natto anti-two days drunk " more.
Bacillus natto in the natto has powerful adjustment gastrointestinal effect.Contain 1,000,000,000 Bacillus nattos in the 1 gram natto.Bacillus natto is not influenced by the strong acid of gastric juice, can arrive enteral by gastric juice smoothly, suppresses the harmful bacterium in the intestinal, and creates a good growth and development environment to probiotics.Harmful bacterium and virus in the intestinal are effectively killed, suppressed to the dipicolinic acid that Bacillus natto produced.Make intestinal flora reach a healthy dynamic equilibrium, solve constipation, enteritis, diarrhoea problem rapidly.
Bacillus natto approximately can be adhered to about 1 week at enteral.Even therefore do not replenish Bacillus natto every day, enteral also can enliven Bacillus natto always.When enteral replenishes Bacillus natto, other breeding bacterium also can correspondingly increase.Intestinal bacterium as mentioned above, weight is about 1 kilogram.Certainly it needs the bait food to supply with.The nutrition of absorption of human body is eaten with regard to the bait that becomes intestinal bacterium and is engulfed, and just can lose weight thus.The ultimate principle of Bacillus natto fat-reducing that Here it is.In general, the Bacillus natto fat-reducing can not make body weight reduce sharply.The diet consumption is constant, and body weight can slowly reduce; Superoxide dismutase in the natto is exactly a kind of enzyme free radical scavenger, can reduce the generation of free radical, makes us avoid the influence of free radical and causes disease or senilism, thereby reach the effect of beauty treatment.
Folium Ginkgo extract can be brought into play anti-oxidation characteristics at brain in eyeball retina and the cardiovascular system.Its antioxidation in brain and central nervous system has and helps to prevent the brain function decline that causes because of the age.The anti-oxidation function of Folium Ginkgo extract in brain makes the people interested especially.Brain and central nervous system are subject to free radical especially and attack.Free radical causes cerebral lesion to be widely regarded as causing following aging and the influence factor of the multiple disease of coming.The effect that patients' up to ten thousand hundreds of scientific researches have confirmed Folium Ginkgo extract is to the effectiveness of the problems of the intellectual deterioration that comprises the not enough and gerontal patient of big cerebral blood flow.Folium Ginkgo extract can promote the circulation of brain and health limbs simultaneously.An its main health care suppresses a kind of material that is called platelet activating factor (PAF) exactly, and PAF is a kind of medium that discharges from cell, and it can cause platelet aggregation (being deposited in together).High-load PAF can cause neural cell injury, and central nervous system's blood flow reduces, inflammation, and bronchoconstriction.Closely similar with free radical, high PAF level also can cause aging.Bilobalide and bilobalide can protect central nervous system's neurocyte injury-free at ischemia (in-vivo tissue lacks oxygen) in period.This function may be able to have the effect of auxiliary treatment to the patient who suffers from apoplexy.Except suppressing thrombocyte adhesiveness, Semen Ginkgo extrac is regulated antiotasis and elastic force.In other words, it can make the blood vessel effective percentage more that circulates.This lifting cycle efficieny effect all has same purpose to trunk in the blood circulation (tremulous pulse) and less blood vessel (blood capillary).
Radix Salviae Miltiorrhizae extract mainly contains fat-soluble non-quinochrome compounds, as Tanshinone I I A, Tanshinone I I B, cryptotanshinone and isomer thereof.Soluble salvianolic acid constituents such as protocatechualdehyde, danshensu.Wherein, cryptotanshinone is antimicrobial effective ingredient.Can improve coronary artery circulation, suppress thrombus disease and take place.Danshensu has remarkable coronary artery dilator, and coronary blood flow increasing reduces myocardial oxygen consumption, the effect of decreased heart rate and increase myocardial contraction.
Summary of the invention
Composition of the present invention and content are: natto extract 100mg, and Folium Ginkgo extract 60mg, Radix Salviae Miltiorrhizae extract 40mg makes the 500mg/ grain with soybean oil, Cera Flava and rubber.
The specific embodiment
1, each supplementary material is tested by quality standard separately, can receive after the assay was approved to feed intake.
2, batching
1. with natto extract, Folium Ginkgo extract, Radix Salviae Miltiorrhizae extract and the soybean oil mixing and stirring of formula ratio;
2. grind 3 times with colloid mill, it is standby to get content.
3, colloidal sol
Purified water, the glycerol of formula ratio are put in the RJ900B electrical heating glue pot, treated that temperature reaches 60～70 ℃ in the glue pot, drop into the gelatin of formula ratio, be heated to 70～80 ℃, it is molten entirely to be stirred to gelatin.Open the bubble in the vacuum removing glue jar, treat that bubble is eliminated fully after, get 200ml and survey the glue viscosity, viscosity is controlled in 3.2～3.5mps.s scope, puts into BWCJ-300 after filtering with 100 purpose drainage screens and is incubated storing container, leave standstill 2 hours after, standby.
4, pill
Content and glue are carried out capsular preparation through RJWJ-185B soft capsule pellet press, the maintenance rotating speed is 2-3.0r/min, the sprinkler body temperature keeps 30-60 ℃, the content weight feed, encapsulated becomes ball, the soft gelatin capsule that presses is fallen on the conveyer belt from main frame, and conveyer is sent soft gelatin capsule into the DGZL-470 dry rotating cage of finalizing the design and finalized the design 3 hours.18～24 ℃ of ambient temperatures, relative humidity 45～65%.
5, the ball that dries in the air
The soft gelatin capsule that makes is put into the dish that dries in the air, and can not surpass 1/2 of the dish height that dries in the air, cool ball 24 hours per hour turns over ball once.The temperature of drying in the air between ball is controlled at 20～24 ℃, and relative humidity is controlled at 20～30%.
6, wash ball
The soft gelatin capsule that dries well is put into soft capsule washing machine, and the edible ethanol with 95% cleans up.
7, the ball that dries in the air
Washed soft gelatin capsule places the dish that dries in the air, and can not surpass 1/2 of the dish height that dries in the air, and entering dries in the air dry in the air between ball ball 30 minutes makes that the edible ethanol volatilization is complete.The temperature of drying in the air between ball is controlled at 20～24 ℃, and relative humidity is controlled at 20～30%.
8, choose ball
The soft gelatin capsule tiling is put on the lamp inspection desk, defective soft gelatin capsules such as leakage of oil, flat ball, deformity, bubble are sorted out.
Claims (3)
1. the prescription that the invention discloses natto Semen Ginkgo soft capsule is formed and preparation method thereof.Composition of the present invention and content are: natto extract 100mg, and Folium Ginkgo extract 60mg, Radix Salviae Miltiorrhizae extract 40mg makes the 500mg/ grain with soybean oil, Cera Flava and rubber.Its preparation method is:
(1), each supplementary material tests by quality standard separately, can receive after the assay was approved to feed intake.
(2), batching
1. with natto extract, Folium Ginkgo extract, Radix Salviae Miltiorrhizae extract and the soybean oil mixing and stirring of formula ratio;
2. grind 3 times with colloid mill, it is standby to get content.
(3), colloidal sol
Purified water, the glycerol of formula ratio are put in the RJ900B electrical heating glue pot, treated that temperature reaches 60～70 ℃ in the glue pot, drop into the gelatin of formula ratio, be heated to 70～80 ℃, it is molten entirely to be stirred to gelatin.Open the bubble in the vacuum removing glue jar, treat that bubble is eliminated fully after, get 200ml and survey the glue viscosity, viscosity is controlled in 3.2～3.5mps.s scope, puts into BWCJ-300 after filtering with 100 purpose drainage screens and is incubated storing container, leave standstill 2 hours after, standby.
(4), pill
Content and glue are carried out capsular preparation through RJWJ-185B soft capsule pellet press, the maintenance rotating speed is 2-3.0r/min, the sprinkler body temperature keeps 30-60 ℃, the content weight feed, encapsulated becomes ball, the soft gelatin capsule that presses is fallen on the conveyer belt from main frame, and conveyer is sent soft gelatin capsule into the DGZL-470 dry rotating cage of finalizing the design and finalized the design 3 hours.18～24 ℃ of ambient temperatures, relative humidity 45～65%.
(5), the ball that dries in the air
The soft gelatin capsule that makes is put into the dish that dries in the air, and can not surpass 1/2 of the dish height that dries in the air, cool ball 24 hours per hour turns over ball once.The temperature of drying in the air between ball is controlled at 20～24 ℃, and relative humidity is controlled at 20～30%.
(6), wash ball
The soft gelatin capsule that dries well is put into soft capsule washing machine, and the edible ethanol with 95% cleans up.
(7), the ball that dries in the air
Washed soft gelatin capsule places the dish that dries in the air, and can not surpass 1/2 of the dish height that dries in the air, and entering dries in the air dry in the air between ball ball 30 minutes makes that the edible ethanol volatilization is complete.The temperature of drying in the air between ball is controlled at 20～24 ℃, and relative humidity is controlled at 20～30%.
(8), choose ball
The soft gelatin capsule tiling is put on the lamp inspection desk, defective soft gelatin capsules such as leakage of oil, flat ball, deformity, bubble are sorted out.
2. prescription according to claim 1 is formed, and it is characterized in that its prescription is formed and content is natto extract 100mg, Folium Ginkgo extract 60mg, and Radix Salviae Miltiorrhizae extract 40mg makes the soft capsule of 500mg/ grain with soybean oil, Cera Flava and rubber.
3. prescription according to claim 1 is formed, and it is characterized in that natto extract is made soft capsule class health food is used for health care and beauty treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101051746A CN102138968A (en) | 2010-02-03 | 2010-02-03 | Soft capsule containing natto and gingko |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101051746A CN102138968A (en) | 2010-02-03 | 2010-02-03 | Soft capsule containing natto and gingko |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102138968A true CN102138968A (en) | 2011-08-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101051746A Pending CN102138968A (en) | 2010-02-03 | 2010-02-03 | Soft capsule containing natto and gingko |
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| Country | Link |
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| CN (1) | CN102138968A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872306A (en) * | 2012-09-25 | 2013-01-16 | 深圳市安美信生物医药科技有限公司 | Compound selenium Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN103349289A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Preparation method of fish oil soft capsules |
| CN104127580A (en) * | 2014-06-30 | 2014-11-05 | 江苏伟楼生物科技有限公司 | Ginkgo softgel and preparation method thereof |
| CN104256583A (en) * | 2014-09-05 | 2015-01-07 | 洛阳华以生物工程有限公司 | Formula of health-care product adopting natto freeze-dried powder and ginkgo biloba extract as main materials |
| CN107041865A (en) * | 2016-02-05 | 2017-08-15 | 重庆井谷元食品科技有限公司 | A kind of natto particle with beauty functions and preparation method thereof |
| CN107156702A (en) * | 2017-04-28 | 2017-09-15 | 防城港市渔业技术推广站 | Deep-sea fish oil soft capsules containing natto extract and preparation method thereof |
| CN107828685A (en) * | 2017-11-15 | 2018-03-23 | 江苏大学 | A kind of bacillus subtilis mutagenic strain of high-yield nattokinase and its application |
-
2010
- 2010-02-03 CN CN2010101051746A patent/CN102138968A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872306A (en) * | 2012-09-25 | 2013-01-16 | 深圳市安美信生物医药科技有限公司 | Compound selenium Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN103349289A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Preparation method of fish oil soft capsules |
| CN104127580A (en) * | 2014-06-30 | 2014-11-05 | 江苏伟楼生物科技有限公司 | Ginkgo softgel and preparation method thereof |
| CN104256583A (en) * | 2014-09-05 | 2015-01-07 | 洛阳华以生物工程有限公司 | Formula of health-care product adopting natto freeze-dried powder and ginkgo biloba extract as main materials |
| CN104256583B (en) * | 2014-09-05 | 2016-05-11 | 洛阳华以生物工程有限公司 | A kind of formula taking freeze dry powder of fermented soybean and ginkgo biloba p.e as main health products |
| CN107041865A (en) * | 2016-02-05 | 2017-08-15 | 重庆井谷元食品科技有限公司 | A kind of natto particle with beauty functions and preparation method thereof |
| CN107156702A (en) * | 2017-04-28 | 2017-09-15 | 防城港市渔业技术推广站 | Deep-sea fish oil soft capsules containing natto extract and preparation method thereof |
| CN107828685A (en) * | 2017-11-15 | 2018-03-23 | 江苏大学 | A kind of bacillus subtilis mutagenic strain of high-yield nattokinase and its application |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20110803 |