CN113577038A - Ginkgo leaf soft capsule - Google Patents
Ginkgo leaf soft capsule Download PDFInfo
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- CN113577038A CN113577038A CN202111020274.3A CN202111020274A CN113577038A CN 113577038 A CN113577038 A CN 113577038A CN 202111020274 A CN202111020274 A CN 202111020274A CN 113577038 A CN113577038 A CN 113577038A
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- ginkgo leaf
- soft capsule
- filling liquid
- ginkgo
- weight
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- 241000218628 Ginkgo Species 0.000 title claims abstract description 34
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 34
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- 239000007788 liquid Substances 0.000 claims abstract description 40
- 238000011049 filling Methods 0.000 claims abstract description 32
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- 235000013736 caramel Nutrition 0.000 claims abstract description 14
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 239000000084 colloidal system Substances 0.000 claims description 15
- 229940068052 ginkgo biloba extract Drugs 0.000 claims description 14
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- 239000006187 pill Substances 0.000 claims description 12
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- 239000000126 substance Substances 0.000 description 2
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- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 201000001431 Hyperuricemia Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
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- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002115 aflatoxin B1 Substances 0.000 description 1
- OQIQSTLJSLGHID-WNWIJWBNSA-N aflatoxin B1 Chemical compound C=1([C@@H]2C=CO[C@@H]2OC=1C=C(C1=2)OC)C=2OC(=O)C2=C1CCC2=O OQIQSTLJSLGHID-WNWIJWBNSA-N 0.000 description 1
- 229930020125 aflatoxin-B1 Natural products 0.000 description 1
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- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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Abstract
The invention belongs to the field of health-care food, and particularly relates to a ginkgo leaf soft capsule which comprises filling liquid and a capsule shell, wherein the capsule shell is prepared from a glue solution, and the filling liquid comprises the following components in parts by weight: 155-175g of ginkgo leaf extract, 320g of soybean oil 304 and 21-25g of beeswax; the glue solution comprises the following components in parts by weight: 90-110g of gelatin, 90-110g of purified water, 39-43g of glycerol and 1-5g of caramel pigment. The ginkgo leaf soft capsule is prepared by taking ginkgo leaf extract, soybean oil, beeswax, gelatin, purified water, glycerol and caramel pigment as main raw materials, wherein each 100g of the ginkgo leaf soft capsule contains 4.4g of total flavonoids serving as active ingredients, has an obvious effect on reducing blood fat, is convenient to circulate in the market, is popularized in a health food mode, is easier to be contacted by the public and is convenient to further popularize and use.
Description
Technical Field
The invention belongs to the field of health-care food, and particularly relates to a ginkgo leaf soft capsule.
Background
Blood lipids are fats in blood and essential substances for basic metabolism of living cells, and main components in blood lipids are cholesterol and triglycerides. A large number of researches show that hyperlipidemia is a key influence factor of stroke, coronary heart disease, myocardial infarction, renal failure and the like; is an important risk factor for promoting hypertension, abnormal glucose tolerance and diabetes; hyperlipidemia can also cause fatty liver, liver cirrhosis, gallstone, pancreatitis, fundus hemorrhage, peripheral vascular disease, hyperuricemia, etc., and is extremely harmful to human bodies.
The pharmacological action of the ginkgo leaf extract is very wide, and the ginkgo leaf extract comprises the following main components: the ginkgo flavonoid glycoside, the bilobalide and the like have better curative effects on cardiovascular and cerebrovascular diseases and better curative effects on lipid regulation, but the ginkgo extract is mainly embodied in medicine for treating hyperlipidemia, has less contact in daily life of people and is inconvenient for popularization and use.
For this reason, we propose a ginkgo biloba leaf soft capsule to solve the above problems.
Disclosure of Invention
The invention aims to solve the problems and provides a ginkgo leaf soft capsule which is convenient to popularize and can effectively reduce blood fat.
In order to achieve the purpose, the invention adopts the following technical scheme: the ginkgo leaf soft capsule comprises filling liquid and a rubber shell, wherein the rubber shell is prepared from a rubber solution, and the filling liquid comprises the following components in parts by weight: 155-175g of ginkgo leaf extract, 320g of soybean oil 304 and 21-25g of beeswax; the glue solution comprises the following components in parts by weight: 90-110g of gelatin, 90-110g of purified water, 39-43g of glycerol and 1-5g of caramel pigment.
In the above folium Ginkgo soft capsule, the weight ratio of the filling liquid to the gelatin liquid is 250: 61.
In the above folium Ginkgo soft capsule, the total flavone content of folium Ginkgo extract is greater than or equal to 18%.
In the above ginkgo leaf soft capsule, the production method of the filling liquid comprises the following steps:
s1, taking the ginkgo biloba extract according to the weight parts, sieving the ginkgo biloba extract by a 100-mesh sieve, taking the soybean oil with the corresponding weight parts, heating the soybean oil to 80 ℃, mixing the soybean oil with beeswax, and forming oil wax liquid after the beeswax is completely dissolved;
s2, mixing the ginkgo biloba extract obtained in the step S1 and the oily wax liquid, and stirring for 30min to obtain a mixed colloid A;
and S3, grinding the mixed colloid A in a colloid mill for three times, then carrying out defoaming treatment, keeping the vacuum degree at-0.06 Mpa, and standing to obtain the filling liquid.
In the above folium Ginkgo soft capsule, the production method of the glue solution comprises the following steps:
s1, putting glycerol and purified water in parts by weight into a glue melting tank, and uniformly mixing, wherein the temperature of the glue melting tank is kept at 70-80 ℃ during the period;
s2, adding gelatin and caramel pigment in corresponding weight parts into a gelatin melting tank, and continuously stirring until the gelatin and the pigment are completely dissolved to obtain a mixed colloid B;
s3, carrying out defoaming treatment on the mixed colloid B, keeping the vacuum degree at-0.06 Mpa, standing to obtain a glue solution, and storing in an environment of 50-60 ℃.
A production method of a ginkgo leaf soft capsule comprises the following steps:
the method comprises the following steps: placing the filling liquid and the glue solution into an automatic rotary soft capsule pill pressing machine for pressing, wherein the specification is 0.5 g/pill;
step two: standing the pressed pill capsules for 4 hours in an environment with the temperature of 20-24 ℃ and the relative humidity of 30-40%;
step three: washing with 95% edible ethanol, drying, selecting pill, and packaging.
Compared with the prior art, the ginkgo leaf soft capsule has the advantages that:
the ginkgo leaf soft capsule is prepared by taking ginkgo leaf extract, soybean oil, beeswax, gelatin, purified water, glycerol and caramel pigment as main raw materials, wherein each 100g of the ginkgo leaf soft capsule contains 4.4g of total flavonoids serving as active ingredients, has a remarkable effect on reducing blood fat, is convenient to circulate in the market and is convenient to further popularize and use.
Drawings
FIG. 1 is a schematic view of the production process of the ginkgo leaf soft capsule of the present invention;
Detailed Description
The following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
Example 1
The ginkgo leaf soft capsule comprises filling liquid and a rubber shell, wherein the rubber shell is prepared from a rubber solution, and the filling liquid comprises the following components in parts by weight: 155g of ginkgo leaf extract, 320g of soybean oil and 225g of beeswax; the glue solution comprises the following components in parts by weight: 110g of gelatin, 90g of purified water, 43g of glycerol and 1g of caramel pigment.
Preferably, the weight ratio of the filling liquid to the glue solution is 250: 61.
Preferably, the total flavone content of the ginkgo biloba extract is more than or equal to 18 percent.
Example 2
The ginkgo leaf soft capsule comprises filling liquid and a rubber shell, wherein the rubber shell is prepared from a rubber solution, and the filling liquid comprises the following components in parts by weight: 160g of ginkgo leaf extract, 316g of soybean oil and 24g of beeswax; the glue solution comprises the following components in parts by weight: 105g of gelatin, 95g of purified water, 42g of glycerol and 2g of caramel pigment.
Preferably, the weight ratio of the filling liquid to the glue solution is 250: 61.
Preferably, the total flavone content of the ginkgo biloba extract is more than or equal to 18 percent.
Example 3
The ginkgo leaf soft capsule comprises filling liquid and a rubber shell, wherein the rubber shell is prepared from a rubber solution, and the filling liquid comprises the following components in parts by weight: 165g of ginkgo leaf extract, 312g of soybean oil and 23g of beeswax; the glue solution comprises the following components in parts by weight: 100g of gelatin, 100g of purified water, 41g of glycerol and 3g of caramel pigment.
Preferably, the weight ratio of the filling liquid to the glue solution is 250: 61.
Preferably, the total flavone content of the ginkgo biloba extract is more than or equal to 18 percent.
Example 4
The ginkgo leaf soft capsule comprises filling liquid and a rubber shell, wherein the rubber shell is prepared from a rubber solution, and the filling liquid comprises the following components in parts by weight: 170g of ginkgo leaf extract, 308g of soybean oil and 22g of beeswax; the glue solution comprises the following components in parts by weight: 95g of gelatin, 105g of purified water, 40g of glycerol and 4g of caramel pigment.
Preferably, the weight ratio of the filling liquid to the glue solution is 250: 61.
Preferably, the total flavone content of the ginkgo biloba extract is more than or equal to 18 percent.
Example 5
The ginkgo leaf soft capsule comprises filling liquid and a rubber shell, wherein the rubber shell is prepared from a rubber solution, and the filling liquid comprises the following components in parts by weight: 175g of ginkgo leaf extract, 304g of soybean oil and 21g of beeswax; the glue solution comprises the following components in parts by weight: 90g of gelatin, 110g of purified water, 39g of glycerol and 5g of caramel pigment.
Preferably, the weight ratio of the filling liquid to the glue solution is 250: 61.
Preferably, the total flavone content of the ginkgo biloba extract is more than or equal to 18 percent.
The production method of the filling liquid comprises the following steps:
s1, taking the ginkgo biloba extract according to the weight parts, sieving the ginkgo biloba extract by a 100-mesh sieve, taking the soybean oil with the corresponding weight parts, heating the soybean oil to 80 ℃, mixing the soybean oil with beeswax, and forming oil wax liquid after the beeswax is completely dissolved;
s2, mixing the ginkgo biloba extract obtained in the step S1 and the oily wax liquid, and stirring for 30min to obtain a mixed colloid A;
and S3, grinding the mixed colloid A in a colloid mill for three times, then carrying out defoaming treatment, keeping the vacuum degree at-0.06 Mpa, and standing to obtain the filling liquid.
The production method of the glue solution comprises the following steps:
s1, putting glycerol and purified water in parts by weight into a glue melting tank, and uniformly mixing, wherein the temperature of the glue melting tank is kept at 70-80 ℃ during the period;
s2, adding gelatin and caramel pigment in corresponding weight parts into a gelatin melting tank, and continuously stirring until the gelatin and the pigment are completely dissolved to obtain a mixed colloid B;
s3, carrying out defoaming treatment on the mixed colloid B, keeping the vacuum degree at-0.06 Mpa, standing to obtain a glue solution, and storing in an environment of 50-60 ℃.
The production method of the ginkgo leaf soft capsule comprises the following steps:
the method comprises the following steps: placing the filling liquid and the glue solution into an automatic rotary soft capsule pill pressing machine for pressing, wherein the specification is 0.5 g/pill;
step two: standing the pressed pill capsules for 4 hours in an environment with the temperature of 20-24 ℃ and the relative humidity of 30-40%;
step three: washing with 95% edible ethanol, drying, selecting pill, and packaging.
The following table was obtained after the test:
table 1 physical and chemical indexes:
| item | Index (I) | Detection method |
| Ash content% | ≤6.0 | GB 5009.4 |
| Disintegration time limit, min | ≤60 | People's republic of China |
| Acid value, mgKOH/g | ≤4.5 | GB 5009.229 |
| Peroxide number, g/100g | ≤0.25 | GB 5009.227 |
| Lead (in Pb), mg- | ≤2.0 | GB 5009.12 |
| Total arsenic (As), mg | ≤1.0 | GB 5009.11 |
| Total mercury (in Hg), mg | ≤0.3 | GB 5009.17 |
| Sixty six, mg/kg | ≤0.1 | GB/T 5009.19 |
| Di Bian, mg/kg | ≤0.1 | GB/T 5009.19 |
| Aflatoxin B1, μ g | ≤10.0 | GB 5009.22No.19001 |
Table 2 microbial indicators:
| item | Index (I) | Detection method |
| The total number of colonies, | ≤30000 | GB 4789.2 |
| the intestinal flora is cultured in a large intestine, | ≤0.92 | GB 4789.3 "MPN count |
| Mold and yeast | ≤25 | GB 4789.15 |
| Golden yellow grape | ≤0/25g | GB 4789.10 |
| Salmonella | ≤0/25g | GB 4789.4 |
Table 3 content determination of the marker ingredients:
| item | Index (I) | Detection method |
| Total flavonoids (calculated by rutin), | ≥4.4 | 1 determination of Total Flavonoids |
The quality requirement of the ginkgo leaf extract is as follows:
tests prove that the ginkgo leaf soft capsule is prepared by taking ginkgo leaf extract, soybean oil, beeswax, gelatin, purified water, glycerol and caramel pigment as main raw materials, contains 4.4g of total flavonoids serving as active ingredients per 100g, and has a remarkable effect of reducing blood fat.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (6)
1. The ginkgo leaf soft capsule comprises filling liquid and a rubber shell, wherein the rubber shell is prepared from a rubber solution, and is characterized in that the filling liquid comprises the following components in parts by weight: 155-175g of ginkgo leaf extract, 320g of soybean oil 304 and 21-25g of beeswax; the glue solution comprises the following components in parts by weight: 90-110g of gelatin, 90-110g of purified water, 39-43g of glycerol and 1-5g of caramel pigment.
2. The ginkgo leaf soft capsule of claim 1, wherein the weight ratio of the filling liquid to the glue liquid is 250: 61.
3. The folium ginkgo soft capsule of claim 1, wherein the total flavone content of the folium ginkgo extract is greater than or equal to 18%.
4. The ginkgo leaf soft capsule according to claim 1, wherein the method for producing the filling liquid comprises the following steps:
s1, taking the ginkgo biloba extract according to the weight parts, sieving the ginkgo biloba extract by a 100-mesh sieve, taking the soybean oil with the corresponding weight parts, heating the soybean oil to 80 ℃, mixing the soybean oil with beeswax, and forming oil wax liquid after the beeswax is completely dissolved;
s2, mixing the ginkgo biloba extract obtained in the step S1 and the oily wax liquid, and stirring for 30min to obtain a mixed colloid A;
and S3, grinding the mixed colloid A in a colloid mill for three times, then carrying out defoaming treatment, keeping the vacuum degree at-0.06 Mpa, and standing to obtain the filling liquid.
5. The ginkgo leaf soft capsule of claim 1, wherein the glue solution is prepared by the following steps:
s1, putting glycerol and purified water in parts by weight into a glue melting tank, and uniformly mixing, wherein the temperature of the glue melting tank is kept at 70-80 ℃ during the period;
s2, adding gelatin and caramel pigment in corresponding weight parts into a gelatin melting tank, and continuously stirring until the gelatin and the pigment are completely dissolved to obtain a mixed colloid B;
s3, carrying out defoaming treatment on the mixed colloid B, keeping the vacuum degree at-0.06 Mpa, standing to obtain a glue solution, and storing in an environment of 50-60 ℃.
6. The method for producing ginkgo leaf soft capsules according to any one of claims 1 to 5, which comprises the steps of:
the method comprises the following steps: placing the filling liquid and the glue solution into an automatic rotary soft capsule pill pressing machine for pressing, wherein the specification is 0.5 g/pill;
step two: standing the pressed pill capsules for 4 hours in an environment with the temperature of 20-24 ℃ and the relative humidity of 30-40%;
step three: washing with 95% edible ethanol, drying, selecting pill, and packaging.
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