CN106433949A - Low-acid-value Yunnan pine seed oil, preparation method and application thereof - Google Patents
Low-acid-value Yunnan pine seed oil, preparation method and application thereof Download PDFInfo
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- CN106433949A CN106433949A CN201610813926.1A CN201610813926A CN106433949A CN 106433949 A CN106433949 A CN 106433949A CN 201610813926 A CN201610813926 A CN 201610813926A CN 106433949 A CN106433949 A CN 106433949A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
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- C11B1/04—Pretreatment of vegetable raw material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/06—Production of fats or fatty oils from raw materials by pressing
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11B3/00—Refining fats or fatty oils
- C11B3/02—Refining fats or fatty oils by chemical reaction
- C11B3/04—Refining fats or fatty oils by chemical reaction with acids
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/02—Refining fats or fatty oils by chemical reaction
- C11B3/06—Refining fats or fatty oils by chemical reaction with bases
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Abstract
The invention discloses a low-acid-value Yunnan pine seed oil and a preparation method thereof, the invention further provides an application of the pine seed oil in foods and treatment of cardiovascular and cerebrovascular diseases and other diseases. The capsule disclosed by the invention can promote normal metabolism of cholesterol, so that the plasma cholesterol can be reduced, the function of promoting lipid deposition in the endothelial cells of the artery by blood platelets can be obviously inhibited, the blood platelet aggregation can also be reduced, the thrombosis can be inhibited, and the fasting blood glucose of a patient can be remarkably improved.
Description
Technical field
The present invention relates to plant extract field, more particularly to a kind of pine nut extract.
Background technology
Pine nut is the seed of famous and precious seeds Pinus koraiensis.It is distributed mainly on northeast Changbai Mountain mountain range and the Xiaoxinanlin Mountains woods of China
Area, belongs to country-level Endangered species, and wild Pinus koraiensis need to grow 50 years rears and start to set seeds, about two years period of maturation.Therefore extremely precious
Expensive.Its seed grain is big, and kernel is delicious, is described as " peanut ", " Solanum muricatum ", and is subject to the green grass or young crops of people with higher nutritive value
Look at.Which is edible with a long history, belongs to free of contamination senior organic green food.
Show according to relevant information, Pinus koraiensis seed oil content is up to 78%, protein 14.8%, and contains multivitamin, is
Of great value woody oleiferous plants and health food.Rich in proteins, carbohydrate and substantial amounts of Ve composition and interior in pignolia core
Fatty acid, Oleic acid containing abundant vitamin A and E and needed by human body, linoleic acid plus linolenic acid, also having in other plants is not had
Pinolenic acid etc..Often eat and can prevent heart disease；Reduction blood fat, vessel softening, grow face beauty.
Semen pini koraiensis are the kernels of pinaster, and its fat content is especially enriched, and act on preferable skin moistening.《Mingyi Bielu》
Carry：Semen pini koraiensis " skin of can moistening drives away dead flesh ".Because women have a haggard face, skin is coarse, and body and the spirit is withered, if be not by
Disease causes, caused by being just because that fat lacks.If often eating Semen pini koraiensis, oils and fatss energy nutrition skin therein, if daily
Several are eaten, is adhered to half a year, skin gradually will be shown in moist, and radiant, wrinkle can also be reduced.
Semen Pini is both ambrosia, is diet good food again, and Semen pini koraiensis contain more than the 100 kind of composition beneficial to human body, have
Original alimentary health-care function, therefore have the good reputation of " peanut ".
In 1919, pharmacology pioneer had found a kind of physiologically active gamma-Linolenic acid first from Radix Oenotherae erythrosepalae, due to γ-
Linolenic acid and its range of metabolic thing all have important and wide in immune system, cardiovascular system, reproductive system, hormonal system
General physiological effect, so the numerous scholars in various countries have done substantial amounts of research, examination to its structure, pharmacology, toxicity and development and application
Test work, it is found that the plant for including gamma-Linolenic acid composition is many, such as Radix Oenotherae erythrosepalae, black plus a unit of measure used in ancient China, SHANHAI PILL, borage, Semen Sesami,
Herba Carpesii Cernui, rubber seed, Ma Liguo, Semen Lini, Fructus Hippophae, Princepia utilis, black currant, Tibet Microula sikkimensis, Symphytum officinale, rough grass, Semen Juglandiss,
Tens of kinds of spirulina etc., all gamma-Linolenic acid containing varying number in above-mentioned tens of kinds of plant seeds, only content is relatively low,
General content all below 10%, moiety content higher but containing severe toxicity, such as Fructus Hippophae, Princepia utilis etc., after detoxification, content is therewith
Reduce.And the method for existing production gamma-Linolenic acid is nothing more than plant extraction method and biological fermentation process, no matter extraction process difference,
Equipment quality is different, but disposably extracts the pure content of gamma-Linolenic acid all not less than 15%.And extracting method is loaded down with trivial details, it is desirable to technique
Complexity, equipment requirements height.
Content of the invention
An object of the present disclosure is to provide a kind of low acid value pinus yunnanensis faranch Oleum pini koraiensis.
The second purpose of the present invention is to provide a kind of preparation method of low acid value pinus yunnanensis faranch Oleum pini koraiensis.
The 3rd purpose of the present invention is to provide the application of low acid value pinus yunnanensis faranch Oleum pini koraiensis.
In order to realize the purpose of the present invention, the invention provides following technical scheme：
Low acid value pinus yunnanensis faranch Oleum pini koraiensis of the present invention, with pine nut as raw material, through screening, dry, with oil press repeatedly
Squeezing, then after filtering, multiple deacidification, acid value≤0.5mg KOH/g is made, with 50 DEG C of hot wash of water temperature, vacuum dehydration, i.e.,
Obtain pinus yunnanensis faranch Oleum pini koraiensis；Content >=25% of gamma-Linolenic acid in the pinus yunnanensis faranch Oleum pini koraiensis.
Low acid value pinus yunnanensis faranch Oleum pini koraiensis described in the present invention 1, its preparation process is followed successively by：
(1) with pine nut as raw material, through screening, selecting crude drugs with winnower, flotation, the removal of impurity is gone, then dries at a temperature of 40 DEG C -60 DEG C；
(2) through crushing roll pressed compact, oil press is squeezed repeatedly, is filtered, is obtained crude oil；
(3) phosphoric acid solution of mass fraction 5% and the citric acid solution of mass fraction 10% are added, at 25 DEG C -80 DEG C
Standing sedimentation 4h is mixed, oil-yielding stratum is separated, is vacuum dried to obtain degummed oil；
(4) 7% sodium hydroxide solution of volume fraction being added, deacidification is carried out at 60 DEG C, make acid value reach 1.0～1.5mg
KOH/g, plus 50 DEG C of hot washes, precipitation draining after 6 hours；
(4) add 10% sodium hydroxide solution of volume fraction again, at 60 DEG C, carry out deacidification, make acid value reach 0.5～
1.0mg KOH/g, plus 50 DEG C of hot washes, precipitation draining after 6 hours；
(5) add 14% sodium hydroxide solution again, at 60 DEG C, deacidification is carried out, acid value≤0.5mg KOH/g is made, plus 50
DEG C hot wash, precipitation draining after 6 hours；
(6) with the multiple agitator treating of the hot water of 50 DEG C of water temperature, washed after all precipitating draining in 6 hours after each agitator treating again
Wash, last vacuum dehydration, the waste water after emptying washing, obtain low acid value pinus yunnanensis faranch Oleum pini koraiensis.
The preparation method of low acid value pinus yunnanensis faranch Oleum pini koraiensis of the present invention, further includes low acid value pinus yunnanensis faranch pine nut
Oil plus decolorising agent are decolourized, cooling, after filtration, produce capsule with capsule machine.
The preparation method of low acid value pinus yunnanensis faranch Oleum pini koraiensis of the present invention, wherein, the decolorising agent is chemical decolorization agent
Oils and fatss are net, and consumption is 0.05%～0.3%；Decoloration process is decolourized for atmospheric low-temperature.
Application of the low acid value pinus yunnanensis faranch Oleum pini koraiensis of the present invention in health food is prepared.
Application of the low acid value pinus yunnanensis faranch Oleum pini koraiensis of the present invention in preventing and treating cardiovascular and cerebrovascular diseases medicament is prepared.
Low acid value pinus yunnanensis faranch Oleum pini koraiensis of the present invention application further in blood lipid-lowering medicine is prepared.
Low acid value pinus yunnanensis faranch Oleum pini koraiensis of the present invention application further in antithrombotic agent is prepared.
Compared with prior art, it is characteristic of the invention that：
(1) product of the present invention is with pure natural higher plant seed as raw material, is extracted using modern technologies, refined forms.
Containing the indispensable unsaturated fatty acid of abundant human body, growth, the development of cranial nerve can be promoted, be baby, child, blue or green few
Year, hyperlipemic patients, the ultimate food of hyperglycemia population.Without preservative, pigment hinders the additive of health with other.
Disposably from pine nut, gamma-Linolenic acid can be extracted, pure content is all more than 25%.
(2) extraction process is simple, using general squeezing process, plus degumming, deacidification, desolventing technology, it is to avoid ferment
High-quality overcritical of high, smart equipment needed for method production, high propagating technology and management personnel, it also avoid that solvent extraction brings becomes
Product solvent residual is difficult to the difficult problem for eliminating, and stable content；Acid value is less than 0.5mg KOH/g, safer health.
(3) degumming acid is phosphoric acid and citric acid, and less with acid amount, degumming is more thorough；Alkali liquor used by deacidification is low dense
Degree alkali liquor, cost-effective and energy consumption.
(4) decolorising agent is that chemical decolorization agent oils and fatss are net, does not need deodorize, compare activated decoloration fat residue after decolouring
Bad smell, needs high temperature long-time deodorization procedures, can energy saving consumption reach more than 80%.This decolorising agent is nontoxic, depletion of QI
Taste, after being finished with material without residue, non-oil consumption, not entrained oil (active hargil entrainment 20～50%), free from environmental pollution (do not have
The useless filtering residue discharge of active hargil).Technique decolourizes to be changed to normal pressure, low temperature decolouring by vacuum, high temperature, has saved the electricity charge and fuel
Take.
(5) dihomo-gamma linolenic acid can be metabolized as gamma-Linolenic acid is entered after human body, (DGLA), arachidonic acid (AA)
With leukotriene (LT), and then a series of metabolism of human body and life synthesis can be directly participated in, the biochemical activity of cell be adjusted, can be risen
High human body high density lipoprotein, reduces low density lipoprotein, LDL, prevents arteriosclerosis, defying age, blood sugar lowering, the preventing and treating heart in blood fat reducing
The aspects such as cerebrovascular disease all have special role, and while have antibacterial action, anti AIDS virus infection effect, antitumor work
With, resist atherosis effect, Blood pressure regulation etc., therefore the present invention can be developed further into as food, health food, health care
The products such as medicine, medicine.
Show from clinical trial, the capsule system for taking the present invention can promote cholesterol homergy, decline blood plasma sterin.
Promote the function of lipidosiss to have obvious inhibiting effect in arterial endothelial cell platelet, can also reduce hematoblastic solidifying
Collection, inhibition thrombosis.Additionally, patient's fasting glucose is significantly improved.
The gamma-Linolenic acid (GLA) (γ-linolenic acid) that the present invention is extracted from pine nut, molecular formula is C18H30O2,
Chemical constitution is for 18 carbon triolefins to methyl ester, and biological key is arranged as：Octadeca-6、9、12-teienoicacid.
Polyunsaturated fatty acid is extensively recognized for people to the important function of health, its Linoleic acid, Caulis et Folium Lini
Acid and arachidonic acid are referred to as essential fatty acid, although containing enough Asias in meals because voluntarily synthesizing in human body body
Oleic acid, still has considerable people keep linolenic normal contents in blood by linoleic conversion, therefore enough
Linolenic acid still must absorb from meals.Therefore, gamma-Linolenic acid has become a kind of important functional food ingredient.
The nutrition health-care functions of gamma-Linolenic acid：
1st, anti-cardiovascular disease effect
Thromboxane A2 (TXA2) is the most strong platelet aggregating agent of endogenouss and vasoconstrictor, and prostacyclin
(PGI2) it is most strong vasodilation.Both normal body keep balance, to maintain platelet physiological action.Once TXA2 is closed
Become to increase, PGI2 is generated and reduced, then increase platelet aggregation, cause thrombosis.Gamma-Linolenic acid antithrombotic cardiovascular mechanisms：
(1) GLA suppresses platelet aggregation as PGE1 precursor；(2) GLA changes into DHA, gamma-Linolenic acid suppression platelet T XA2 synthesis
Enzymatic activity.Therefore, in terms of to thrombosiss, gamma-Linolenic acid has the effect for mitigating, it is possible to decrease cause thrombotic cardiovascular and cerebrovascular disease
Danger outer, it can also suppress the formation of the athero- shape sclerosiss of tremulous pulse, protect ischemic myocardial, reduce necrotic area, maintain blood little
The normal function of plate.
2nd, effect for reducing blood fat
Gamma-Linolenic acid can reduce T-CHOL as the precursor of PGE1, and gamma-Linolenic acid can increase the polarity of cholesterol and water
Dissolubility, is allowed to easily be digested, and can also remove triglyceride from blood, reduces the synthesis of endogenous cholesterol, so as to reduce β-
The generation of lipoprotein.Therefore, gamma-Linolenic acid can reduce total cholesterol level in blood, play a part of blood fat reducing.γ-Caulis et Folium Lini
Acid be current report treatment hyperlipidemia curative effect preferably, safety highest medicine.
3rd, hypoglycemic activity
The phospholipid being made up of gamma-Linolenic acid can strengthen the mobility of phospholipid on cell membrane, strengthen cell-membrane receptor to swashing
The sensitivity of plain (including insulin).The prostaglandin isoreactivity material for being come by gamma-Linolenic acid, can improve pancreaticβ-cell and divide
Secrete the function of insulin.And gamma-Linolenic acid may also help in the fat for recovering diabetes patient's cell as polyunsaturated fatty acid
The activity of sour desaturase.
4th, antitumaous effect
Gamma-Linolenic acid can be used as potential cancer therapy drug.Research to gamma-Linolenic acid shows, it has significantly anti-grease
Matter Oxidation, because gamma-Linolenic acid is oxidized first in vivo, so as to alleviate cytolipin Peroxidative damage.Research shows,
Gamma-Linolenic acid can suppress hepatoma cell growth.The synthesis of suppression human colon carcinoma, gastric cancer and pancreatic cancer DNA, gamma-Linolenic acid
Plus Fe (II) is to treating breast carcinoma effect is significant.
5th, whitening and resisting age of skin effect
Gamma-Linolenic acid reacts the kojic acid list gamma-Linolenic acid ester for generating with kojic acid can be had as the inhibitor of tryrosinase
The effect that anti-melanin is generated, can be used as the functional factor of whitening cosmetic, it is also possible to make medicinal ointment therapy pigmentation.Separately
Outward, gamma-Linolenic acid can be as the natural oil raw material of cosmetics, with protection skin, moistening skin, delay skin aging and
Treatment chronic eczema, blood circulation promoting etc. is acted on.
Therefore, gamma-Linolenic acid is used as food additive or supplementary, and long-term consumption can improve the knot of human food
Structure, strengthens human immunologic function.Infant, old people, because fat, disease or insobriety cause the adult of metabolism disorder,
The people that mineral element or vitamin intake are not enough, will supplement gamma-Linolenic acid.Some pharmacy external or food company, in order to full
The requirement of the above-mentioned specific consumer group of foot, has been the food of old people and child's development and production containing gamma-Linolenic acid, such as：Cattle
Milk, milk powder, fruit juice, beverage, fruit jelly, cookiess, chocolate, chewing gum etc..
With reference to specific embodiment, pinus yunnanensis faranch Oleum pini koraiensis of the present invention and its preparation method and application are made furtherly
Bright.
Specific embodiment
Embodiment 1
6 tons of pine nut of collection, through screening, selecting crude drugs with winnower, flotation, removes the removal of impurity, native stone, fine sand, dust, ghost, empennage, Ran Hou
Dry at 40 DEG C, through crushing roll pressed compact, squeezed with spiral oil press repeatedly, crude oil is obtained, oil extracting rate is more than 70%.Crude oil is used
Filter press is filtered, and filters off impurity, adds the phosphoric acid solution of mass fraction 5% and the citric acid solution of mass fraction 10%,
Standing sedimentation 4h is mixed at 25 DEG C, oil-yielding stratum is separated, is vacuum dried to obtain degummed oil；7% sodium hydroxide solution is subsequently adding,
Deacidification is carried out at 60 DEG C, make acid value reach 1.5mg KOH/g, plus 50 DEG C of hot washes, precipitation draining after 6 hours；Add again
10% sodium hydroxide solution, carries out deacidification at 60 DEG C, makes acid value reach 1.0mg KOH/g, plus 50 DEG C of hot washes, and precipitation 6 is little
When after draining；Adding 14% sodium hydroxide solution again, deacidification being carried out at 60 DEG C, acid value is 0.2mg KOH/g, plus 50 DEG C of heat
Water washing, precipitation draining after 6 hours；Washed three times with 50 DEG C of hot water stirs of water temperature, all precipitate after each agitator treating 6 hours
Washed after draining again, last vacuum dehydration, the waste water after emptying washing, obtain low acid value pinus yunnanensis faranch Oleum pini koraiensis.
Above-mentioned low acid value pinus yunnanensis faranch Oleum pini koraiensis add 0.3% oils and fatss to carry out only atmospheric low-temperature decolouring, and final color and luster is faint yellow.
After decolouring, cooling is refiltered, and finally produces finished capsule product with capsule machine.
1 pinus yunnanensis faranch Oleum pini koraiensis content analysis of table are reported
| Palmic acid | Stearic acid | Oleic acid | Linoleic acid | Gamma-Linolenic acid | Linolenic acid | Sweet carbon enoic acid | Erucic acid | |
| Embodiment 1 | 3.3743 | 1.4578 | 17.15 | 42.48 | 26.59 | 0.674 | 1.547 | 1.157 |
Pinus yunnanensis faranch pine nut oil capsule clinical effectiveness of the present invention taken by table 2
Embodiment 2
5 tons of pine nut of collection, through screening, selecting crude drugs with winnower, flotation, removes the removal of impurity, native stone, fine sand, dust, ghost, empennage, Ran Hou
Dry at 50 DEG C, through crushing roll pressed compact, squeezed with double pendulum type oil press repeatedly, crude oil is obtained, oil extracting rate is more than 70%.Crude oil is used
Chamber filter press is filtered, and filters off impurity, adds the phosphoric acid solution of mass fraction 5% and the citric acid solution of mass fraction 10%,
Standing sedimentation 4h is mixed at 60 DEG C, oil-yielding stratum is separated, is vacuum dried to obtain degummed oil；7% sodium hydroxide solution is subsequently adding,
Deacidification is carried out at 60 DEG C, make acid value reach 1.2mg KOH/g, plus 50 DEG C of hot washes, precipitation draining after 6 hours；Add again
10% sodium hydroxide solution, carries out deacidification at 60 DEG C, makes acid value reach 0.6mg KOH/g, plus 50 DEG C of hot washes, and precipitation 6 is little
When after draining；Adding 14% sodium hydroxide solution again, deacidification being carried out at 60 DEG C, acid value is 0.4mg KOH/g, plus 50 DEG C of heat
Water washing, precipitation draining after 6 hours；Washed three times with 50 DEG C of hot water stirs of water temperature, all precipitate after each agitator treating 6 hours
Washed after draining again, last vacuum dehydration, the waste water after emptying washing, obtain low acid value pinus yunnanensis faranch Oleum pini koraiensis.
Above-mentioned low acid value pinus yunnanensis faranch Oleum pini koraiensis add 0.05% oils and fatss to carry out only atmospheric low-temperature decolouring, and final color and luster is yellowish
Color.After decolouring, cooling is refiltered, and finally produces finished capsule product with capsule machine.
3 pinus yunnanensis faranch Oleum pini koraiensis content analysis of table are reported
| Palmic acid | Stearic acid | Oleic acid | Linoleic acid | Gamma-Linolenic acid | Linolenic acid | Sweet carbon enoic acid | Erucic acid | |
| Embodiment 2 | 3.162 | 1.5682 | 14.10 | 46.40 | 25.0 | 0.664 | 1.441 | 1.023 |
Pinus yunnanensis faranch pine nut oil capsule clinical effectiveness of the present invention taken by table 4
Embodiment 3
5 tons of pine nut of collection, through screening, selecting crude drugs with winnower, flotation, removes the removal of impurity, native stone, fine sand, dust, ghost, empennage, Ran Hou
Dry at 60 DEG C, through crushing roll pressed compact, squeezed with double pendulum type oil press repeatedly, crude oil is obtained, oil extracting rate is more than 70%.Crude oil is used
Chamber filter press is filtered, and filters off impurity, adds the phosphoric acid solution of mass fraction 5% and the citric acid solution of mass fraction 10%,
Standing sedimentation 4h is mixed at 60 DEG C, oil-yielding stratum is separated, is vacuum dried to obtain degummed oil；7% sodium hydroxide solution is subsequently adding,
Deacidification is carried out at 60 DEG C, make acid value reach 1.3mg KOH/g, plus 50 DEG C of hot washes, precipitation draining after 6 hours；Add again
10% sodium hydroxide solution, carries out deacidification at 60 DEG C, makes acid value reach 0.7mg KOH/g, plus 50 DEG C of hot washes, and precipitation 6 is little
When after draining；Adding 14% sodium hydroxide solution again, deacidification being carried out at 60 DEG C, acid value is 0.4mg KOH/g, plus 50 DEG C of heat
Water washing, precipitation draining after 6 hours；Washed three times with 50 DEG C of hot water stirs of water temperature, all precipitate after each agitator treating 6 hours
Washed after draining again, last vacuum dehydration, the waste water after emptying washing, obtain low acid value pinus yunnanensis faranch Oleum pini koraiensis.
Above-mentioned low acid value pinus yunnanensis faranch Oleum pini koraiensis add 0.1% oils and fatss to be decolourized only, and final color and luster is faint yellow.Cold after decolouring
But refiltering, finally finished capsule product is produced with capsule machine.
5 pinus yunnanensis faranch Oleum pini koraiensis content analysis of table are reported
| Palmic acid | Stearic acid | Oleic acid | Linoleic acid | Gamma-Linolenic acid | Linolenic acid | Sweet carbon enoic acid | Erucic acid | |
| Embodiment 3 | 3.46 | 1.087 | 11.19 | 49.750 | 27.58 | 0.612 | 1.407 | 2.57 |
Pinus yunnanensis faranch pine nut oil capsule clinical effectiveness of the present invention taken by table 6
Embodiment 4
8 tons of pine nut of collection, through screening, selecting crude drugs with winnower, flotation, removes the removal of impurity, native stone, fine sand, dust, ghost, empennage, Ran Hou
Dry at 45 DEG C, through crushing roll pressed compact, squeezed with double pendulum type oil press repeatedly, crude oil is obtained, oil extracting rate is more than 65%.Crude oil is used
Chamber filter press is filtered, and filters off impurity, adds the phosphoric acid solution of mass fraction 5% and the citric acid solution of mass fraction 10%,
Standing sedimentation 4h is mixed at 80 DEG C, oil-yielding stratum is separated, is vacuum dried to obtain degummed oil；7% sodium hydroxide solution is subsequently adding,
Deacidification is carried out at 60 DEG C, make acid value reach 1.2mg KOH/g, plus 50 DEG C of hot washes, precipitation draining after 6 hours；Add again
10% sodium hydroxide solution, carries out deacidification at 60 DEG C, makes acid value reach 0.8mg KOH/g, plus 50 DEG C of hot washes, and precipitation 6 is little
When after draining；Adding 14% sodium hydroxide solution again, deacidification being carried out at 60 DEG C, acid value is 0.3mg KOH/g, plus 50 DEG C of heat
Water washing, precipitation draining after 6 hours；Washed three times with 50 DEG C of hot water stirs of water temperature, all precipitate after each agitator treating 6 hours
Washed after draining again, last vacuum dehydration, the waste water after emptying washing, obtain low acid value pinus yunnanensis faranch Oleum pini koraiensis.
Above-mentioned low acid value pinus yunnanensis faranch Oleum pini koraiensis add 0.2% oils and fatss to be decolourized only, the amount of decolorising agent depending on the oil colours depth,
Final color and luster is faint yellow.After decolouring, cooling is refiltered, and finally produces finished capsule product with capsule machine.
7 pinus yunnanensis faranch Oleum pini koraiensis content analysis of table are reported
| Palmic acid | Stearic acid | Oleic acid | Linoleic acid | Gamma-Linolenic acid | Linolenic acid | Sweet carbon enoic acid | Erucic acid | |
| Embodiment 4 | 3.122 | 1.376 | 17.89 | 48.768 | 27.565 | 0.60 | 1.602 | 2.134 |
Pinus yunnanensis faranch pine nut oil capsule clinical effectiveness of the present invention taken by table 8
Embodiment described above is only that the preferred embodiment of the present invention is described, not the model to the present invention
Enclose and be defined, on the premise of without departing from design spirit of the present invention, technical side of the those of ordinary skill in the art to the present invention
Various modifications and improvement that case is made, all should fall in the protection domain of claims of the present invention determination.
Claims (8)
1. a kind of low acid value pinus yunnanensis faranch Oleum pini koraiensis, it is characterised in that：The pinus yunnanensis faranch Oleum pini koraiensis with pine nut as raw material, through screening,
Dry, squeezed with oil press repeatedly, then after filtering, multiple deacidification, acid value≤0.5mg KOH/g is made, with 50 DEG C of heat of water temperature
Water washing, vacuum dehydration, obtain final product low acid value pinus yunnanensis faranch Oleum pini koraiensis；
Content >=25% of gamma-Linolenic acid in the low acid value pinus yunnanensis faranch Oleum pini koraiensis.
2. low acid value pinus yunnanensis faranch Oleum pini koraiensis according to claim 1, its preparation process is followed successively by：
(1) with pine nut as raw material, through screening, selecting crude drugs with winnower, flotation, the removal of impurity is gone, then dries at a temperature of 40 DEG C -60 DEG C；
(2) through crushing roll pressed compact, oil press is squeezed repeatedly, is filtered, is obtained crude oil；
(3) phosphoric acid solution of mass fraction 5% and the citric acid solution of mass fraction 10% is added, mixes at 25 DEG C -80 DEG C
Standing sedimentation 4h, separates oil-yielding stratum, is vacuum dried to obtain degummed oil；
(4) 7% sodium hydroxide solution of volume fraction being added, deacidification is carried out at 60 DEG C, make acid value reach 1.0～1.5mg KOH/g,
Plus 50 DEG C of hot washes, precipitation draining after 6 hours；
(4) add 10% sodium hydroxide solution of volume fraction again, at 60 DEG C, carry out deacidification, make acid value reach 0.5～
1.0mgKOH/g, plus 50 DEG C of hot washes, precipitation draining after 6 hours；
(5) add 14% sodium hydroxide solution again, at 60 DEG C, deacidification is carried out, make acid value≤0.5mg KOH/g, plus 50 DEG C of heat
Water washing, precipitation draining after 6 hours；
(6) with the multiple agitator treating of the hot water of 50 DEG C of water temperature, washed after all precipitating draining in 6 hours after each agitator treating again, most
Vacuum dehydration afterwards, the waste water after emptying washing, obtain low acid value pinus yunnanensis faranch Oleum pini koraiensis.
3. the preparation method of low acid value pinus yunnanensis faranch Oleum pini koraiensis according to claim 2, further includes low acid value Yunnan
Loose Oleum pini koraiensis add decolorising agent to be decolourized, cooling, after filtration, produce capsule with capsule machine.
4. the preparation method of low acid value pinus yunnanensis faranch Oleum pini koraiensis according to claim 3, it is characterised in that：The decolorising agent is
Chemical decolorization agent oils and fatss are net, and consumption is 0.05%～0.3%；Decoloration process is decolourized for atmospheric low-temperature.
5. application of the low acid value pinus yunnanensis faranch Oleum pini koraiensis described in claim 1 in health food is prepared.
6. application of the low acid value pinus yunnanensis faranch Oleum pini koraiensis described in claim 1 in preventing and treating cardiovascular and cerebrovascular diseases medicament is prepared.
7. the application further in blood lipid-lowering medicine is prepared of the low acid value pinus yunnanensis faranch Oleum pini koraiensis described in claim 5.
8. the application further in antithrombotic agent is prepared of the low acid value pinus yunnanensis faranch Oleum pini koraiensis described in claim 5.
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| CN201610813926.1A CN106433949A (en) | 2016-09-09 | 2016-09-09 | Low-acid-value Yunnan pine seed oil, preparation method and application thereof |
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| CN106675778A (en) * | 2017-03-06 | 2017-05-17 | 贵州侗乡生态农业科技发展有限公司 | Perilla oil refining method |
| CN112457154A (en) * | 2020-09-09 | 2021-03-09 | 昆明沐仁生物科技有限公司 | R-linolenic acid extraction and pinolenic acid preparation method based on Yunnan pine nuts |
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Application publication date: 20170222 |