CN106072563A - A kind of health composition with function of physical fatigue alleviation and preparation method thereof - Google Patents
A kind of health composition with function of physical fatigue alleviation and preparation method thereof Download PDFInfo
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- CN106072563A CN106072563A CN201610508596.5A CN201610508596A CN106072563A CN 106072563 A CN106072563 A CN 106072563A CN 201610508596 A CN201610508596 A CN 201610508596A CN 106072563 A CN106072563 A CN 106072563A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of health composition with function of physical fatigue alleviation and preparation method thereof.The health composition with function of physical fatigue alleviation of the present invention, containing Radix Ginseng extract, Radix Astragali extract, Herba Epimedii extract, Radix Ophiopogonis extract, soybean oil and Cera Flava；Present invention also offers and a kind of comprise described soft capsule of health composition and preparation method thereof.The person that the present invention is directed to fatiguability, theoretical for instructing with Traditional health care, scientifically select, reasonably compatibility, selecting Radix Ginseng, the Radix Astragali, Herba Epimedii and the extract of Radix Ophiopogonis is raw material, all material compatibilities " temperature and the driest, profit and do not tremble with fear " gather that QI invigorating is supporing yang, the effect of YIN nourishing and the production of body fluid promoting altogether, sports fatigue is had good mitigation；The soft capsule dosage form bioavailability height made, good airproof performance, dosage are accurate, effectively cover medical material bad smell, easy to carry, be prone to edible, suitable fatiguability person crowd eats.
Description
Technical field
The invention belongs to technical field of health-care food production, be specifically related to a kind of health care with function of physical fatigue alleviation
Compositions and preparation method thereof.
Background technology
Tired long term accumulation and can not eliminate, arteriopathy fatigue will be developed into, cause the pathological changes of some organ of health
And be detrimental to health, it is necessary so eliminating sports fatigue in time.
Alleviating physical fatigue class health food with Chinese herbal medicine as primary raw material is extensively welcome by consumer in the market.
Great majority are the patterns with buccal tablet, oral liquid etc., and mouthfeel is poor, takes inconvenience.
Summary of the invention
It is an object of the invention to overcome the problems referred to above of prior art, it is provided that a kind of guarantor with function of physical fatigue alleviation
Strong compositions and preparation method thereof.
The health composition with function of physical fatigue alleviation of the present invention, containing Radix Ginseng extract, Radix Astragali extract, excessive
Sheep leaves of pulse plants extract, Radix Ophiopogonis extract, soybean oil and Cera Flava.
Preferably, the described health composition with function of physical fatigue alleviation, by weight, contains:
Radix Ginseng extract 30-45 part, Radix Astragali extract 40-60 part, Herba Epimedii extract 33.36-50.04 part, Radix Ophiopogonis carry
Take thing 120-180 part, soybean oil 403.84-605.76 part and Cera Flava 12.8-19.2 part.
The present invention also provides for a kind of soft capsule with function of physical fatigue alleviation, including soft capsule content and soft capsule
Skin, by weight, soft capsule content contains: Radix Ginseng extract 30-45 part, Radix Astragali extract 40-60 part, Herba Epimedii extract
Thing 33.36-50.04 part, Radix Ophiopogonis extract 120-180 part, soybean oil 403.84-605.76 part and Cera Flava 12.8-19.2 part, soft
Capsule shell contains: gelatin 240-360 part, glycerol 96-144 part, purified water 240-360 part, titanium dioxide 0.3-0.45 part, caramel
Color 14.4-21.6 part and potassium sorbate 0.48-0.72 part.
Preferably, the described soft capsule with function of physical fatigue alleviation, including soft capsule content and soft capsule skin, press
Weight portion meter, soft capsule content contains: Radix Ginseng extract 37.5 parts, Radix Astragali extract 50 parts, Herba Epimedii extract 41.7 parts,
Radix Ophiopogonis extract 150 parts, soybean oil 504.8 parts and 16 parts of Cera Flava, soft capsule skin contains: 300 parts of gelatin, glycerol 120 parts, purification
300 parts of water, titanium dioxide 0.375 part, burnt sugar coloring 18 parts and potassium sorbate 0.60 part.
The present invention also provides for the preparation method of the described soft capsule with function of physical fatigue alleviation, including following step
Rapid:
A. glue liquid: weigh each component of soft capsule skin by described weight portion, each component mixed, heats and stirs all
Even, obtain glue after evacuation bubble removing, filter, stand, the glue after being filtered is standby；
Soft capsule content the most processed: weigh each component of soft capsule content by described weight portion, each component is mixed, adds
Heat also stirs, and obtains soft capsule content；
C. the glue after the soft capsule content prepared, filtration is pressed into soft capsule in soft capsule forming machine, sizing,
It is dried, selects ball, obtain the soft capsule with function of physical fatigue alleviation.
Preferably, the preparation method of the described soft capsule with function of physical fatigue alleviation, comprise the following steps:
A. glue liquid:
1) colloidal sol: weigh each component of soft capsule skin by described weight portion, first titanium dioxide is mixed with qs glycerin, mistake
Colloid mill Automatic Cycle is ground to mix homogeneously, obtains mixed liquor；Burnt sugar coloring, potassium sorbate are dissolved in appropriate purified water, then
Input glue tank together with described mixed liquor, residue purified water, residue glycerol, heats and stirs, the temperature in glue tank to be changed
Reaching 70-75 DEG C, put into gelatin, under the conditions of temperature is less than 75 DEG C, insulated and stirred is until gelatin all dissolves, and obtains glue and mixes
Compound material；
2) evacuation: under the conditions of temperature is less than 75 DEG C, glue mixed material is evacuated to glue bubble-free, glue
Viscosity 18000-30000mpa, venting, obtain glue；
3) filter, stand: by glue through 120 mesh net filtrations, the glue after filtration keep 50-70 DEG C and stand 2 hours with
On, standby；
Soft capsule content the most processed: weigh each component of soft capsule content by described weight portion, first by Cera Flava with appropriate
Soybean oil be heated to 65-75 DEG C, stirring dissolve completely to Cera Flava, obtain oily wax mixture；Take residue soybean oil again, add described
Oily wax mixture stir, add Radix Ginseng extract, Radix Astragali extract, Herba Epimedii extract and Radix Ophiopogonis extract, stir
Mix to mix homogeneously, cross a colloid mill, obtain soft capsule content；
C. pelleting, sizing:
1) pelleting: the glue after soft capsule content, filtration is pressed into soft capsule, ambient temperature in soft capsule forming machine
For 18-26 DEG C, relative humidity be less than 35%, keeping rotating speed is that 2.0-3.5 turns/min, and sprinkler body temperature keeps 36-48 DEG C, rubber
Thickness is 0.65-0.85mm；
2) sizing: the soft capsule pressed 18-26 DEG C, relative humidity be to shape under conditions of less than 35%；
D. be dried: by the soft capsule after sizing 20-25 DEG C, under conditions of relative humidity is less than 35%, aeration-drying
And stir in good time；
E. select ball: examined on lamp inspection desk by dried soft capsule and remove underproof soft capsule, obtain that there is alleviation muscle power
The soft capsule of fatigue function.
Preferably, the evacuation of described step a, its vacuum is-0.08Mpa.
The present invention also provides for the described health composition with function of physical fatigue alleviation, has alleviating physical fatigue merit
The soft capsule of energy is for preparing the application of health food for relieving physical fatigue.
Ginseng sweet, micro-hardship, tepor, return spleen, lung, the heart, kidney channel, have strongly invigorating primordial QI, the effect nourished blood of promoting the production of body fluid.The Radix Astragali is sweet, tepor,
Return lung, spleen channel, have tonifying Qi and lifting yang.Herba Epimedii is pungent, sweet, temperature, returns liver, kidney channel, can kidney-replenishing.Radix Ophiopogonis is sweet, bitter in the mouth, is slightly cold, GUIXIN,
Lung, stomach warp, can YIN nourishing and the production of body fluid promoting.The present invention chooses the extract formula of Radix Ginseng, the Radix Astragali, Herba Epimedii and Radix Ophiopogonis, with Radix Ginseng is wherein
Main, the Radix Astragali, Herba Epimedii, Radix Ophiopogonis are auxiliary.The person that the present invention is directed to fatiguability, scientifically selects for instructing so that Traditional health care is theoretical, closes
Reason ground compatibility, selecting Radix Ginseng, the Radix Astragali, Herba Epimedii and the extract of Radix Ophiopogonis is raw material, all material compatibilities " temperature and the driest, profit and do not tremble with fear "
QI invigorating of gathering altogether is supporing yang, the effect of YIN nourishing and the production of body fluid promoting, has good mitigation to sports fatigue.Modern study also confirms that, more than joins
5 is proper, and function is definite, safely and effectively, is suitable to be eaten for a long time.
The health composition with function of physical fatigue alleviation of the present invention, has effect of above-mentioned various Chinese herbal medicine concurrently, can
Effectively alleviating physical fatigue, makes soft capsule dosage form bioavailability height, good airproof performance, dosage accurately, effectively covers medical material
Bad smell, easy to carry, be prone to edible, suitable fatiguability person crowd eat.
Accompanying drawing explanation
Fig. 1 is the preparation method figure of the soft capsule with function of physical fatigue alleviation of the present invention, note: be 100,000 in dotted line
Level clear production district.
Detailed description of the invention
Following example are to further illustrate the present invention rather than limitation of the present invention.
Radix Ginseng extract, Radix Astragali extract, Herba Epimedii extract and Radix Ophiopogonis extract used in the present invention be by with
Lower section method prepares.
The preparation method of Radix Ginseng extract:
Radix Ginseng is pulverized, the volume fraction 70% ethanol water extraction of addition Radix Ginseng 6～8 times of volumes twice, every time
Extracting 2 hours, united extraction liquid, filter, under the conditions of 70-80 DEG C, concentrating under reduced pressure extracting solution is to relative density 1.15-1.2 (40-50
DEG C survey) concentrated solution, be spray-dried (inlet temperature 170-190 DEG C, leaving air temp 80-90 DEG C), cross 100 mesh sieves, obtain Radix Ginseng
Extract；Its yield is about 15%, and in income earner's conopsea extraction, the content of ginsenoside is about 10%.
The preparation method of Herba Epimedii extract:
Being pulverized by Herba Epimedii, volume fraction 75% ethanol water adding Herba Epimedii 6～8 times of volumes extracts twice,
Extracting 2 hours, united extraction liquid every time, filter, under the conditions of 70-80 DEG C, concentrating under reduced pressure extracting solution is to relative density 1.15-1.2
The concentrated solution of (40-50 DEG C of survey), is spray-dried (inlet temperature 170-190 DEG C, leaving air temp 80-90 DEG C), crosses 100 mesh sieves,
To Herba Epimedii extract；Its yield is about 10%, and in gained Herba Epimedii extract, the content of icariin is about 10%.
The preparation method of Radix Astragali extract:
The Radix Astragali is pulverized, the water extraction of the addition Radix Astragali 6～8 times of volumes twice, extracts 2 hours, united extraction liquid every time,
Filtering, under the conditions of 70-80 DEG C, concentrating under reduced pressure extracting solution is to the concentrated solution of relative density 1.15-1.2 (40-50 DEG C of survey), spray dried
Dry (inlet temperature 170-190 DEG C, leaving air temp 80-90 DEG C), crosses 100 mesh sieves, obtains Radix Astragali extract；Its yield is 10% left side
The right side, in gained Radix Astragali extract, the content of astragalus polysaccharides is about 30%.
The preparation method of Radix Ophiopogonis extract:
To pulverize Radix Ophiopogonis, the water extraction of addition Radix Ophiopogonis 6～8 times of volumes twice, extract 2 hours, united extraction liquid every time,
Filtering, under the conditions of 70-80 DEG C, concentrating under reduced pressure extracting solution is to the concentrated solution of relative density 1.15-1.2 (40-50 DEG C of survey), adds body
Concentration of alcohol in concentrated solution is adjusted to volume fraction 72%-73% by fraction 95% ethanol water, stands more than 6 hours, takes
Lower floor's solution, 70-80 DEG C is evaporated to relative density 1.3 (40-50 DEG C of survey), 60-70 DEG C of vacuum drying, pulverizes, cross 100 mesh
Sieve, obtains Radix Ophiopogonis extract；Its yield is about 30%, and in gained Radix Ophiopogonis extract, the content of Radix Ophiopogonis polysaccharide is about 30%.
Embodiment 1: there is the soft capsule A of function of physical fatigue alleviation
Soft capsule content formula: Radix Ginseng extract 3.75kg, Radix Astragali extract 5kg, Herba Epimedii extract 4.17kg, wheat
Winter extract 15kg, soybean oil 50.48kg, Cera Flava 1.6kg.
Soft capsule skin doses: gelatin 30kg, glycerol 12kg, purified water 30kg, titanium dioxide 37.5g, burnt sugar coloring
1.8kg, potassium sorbate 60g.
The preparation method of the soft capsule A with function of physical fatigue alleviation of the present invention, as it is shown in figure 1, include following step
Rapid:
Step 1: glue liquid
1.1 colloidal sols: accurately weigh the soft capsule A formula proportion amount with function of physical fatigue alleviation by equipment capacity
Gelatin, glycerol, purified water, titanium dioxide, burnt sugar coloring, potassium sorbate.First titanium dioxide is mixed with qs glycerin, cross colloid
Mill Automatic Cycle is ground to mix homogeneously, obtains mixed liquor.Burnt sugar coloring, potassium sorbate are dissolved in appropriate purified water, then with upper
State mixed liquor, residue purified water, residue glycerol input glue tank together heating, the agitator on starting glue tank simultaneously；Treat tank
Interior temperature reaches 70 DEG C-75 DEG C, puts into gelatin, insulated and stirred 50-70min under the conditions of temperature is less than 75 DEG C, until bright
Glue all dissolves to obtain glue mixed material.
1.2 evacuation: by glue mixed material evacuation 30-60min (vacuum-0.08Mpa, temperature≤75 DEG C) to glue
Liquid bubble-free, gelatin viscosity 1.8 ten thousand mpa-3.0mpa, venting, obtain glue.
1.3 filtrations, standing: glue filters 120 mesh nylon wires, the glue after filtration is placed in steady glue bucket holding glue
50-70 DEG C, stand more than 2 hours, standby.
Step 2: soft capsule content processed
2.1 weigh: accurately weigh Radix Ginseng extract by formula proportion amount, Radix Astragali extract, Herba Epimedii extract, Radix Ophiopogonis carry
Take thing, soybean oil, Cera Flava, standby.
2.2 mixing: first Cera Flava and appropriate soybean oil are put in mixer, be heated to 65 DEG C-75 DEG C, stir complete to Cera Flava
Entirely dissolve, obtain oily wax mixture.Again residue soybean oil is placed in another mixer, adds above-mentioned oil wax mixture stirring
15min, adds Radix Ginseng extract, Radix Astragali extract, Herba Epimedii extract, Radix Ophiopogonis extract, and stirring 30min to mixing is all
Even, cross a colloid mill, obtain soft capsule content.
Step 3: pelleting, sizing
3.1 pelletings: the glue after soft capsule content, filtration is pressed into soft capsule, environment temperature in soft capsule forming machine
Degree is 18-26 DEG C, relative humidity≤35%, and keeping rotating speed is that 2.0-3.5 turns/min, and sprinkler body temperature keeps 36-48 DEG C, and rubber is thick
Degree is 0.65-0.85mm.
3.2 sizings: the soft capsule pressed 18-26 DEG C, shape about 3 hours under conditions of relative humidity≤35%.
Step 4: be dried
Will the soft capsule of gained is at 20-25 DEG C after sizing, under conditions of relative humidity≤35%, aeration-drying 18 hours with
On, within first 4 hours, turn over 2 times, turn over ball whole arid cycle no less than 2 times.
Step 5: select ball
By dried qualified after soft capsule examine on lamp inspection desk and go abnormity ball, bubble ball, big piller, leakage of oil ball etc. not to conform to
The soft capsule of lattice, remaining gained is the soft capsule A with function of physical fatigue alleviation.
Embodiment 2: there is the soft capsule B of function of physical fatigue alleviation
Soft capsule content formula: Radix Ginseng extract 3kg, Radix Astragali extract 4kg, Herba Epimedii extract 3.336kg, Radix Ophiopogonis
Extract 12kg, soybean oil 40.384kg, Cera Flava 1.28kg.
Soft capsule skin doses: gelatin 24kg, glycerol 9.6kg, purified water 24kg, titanium dioxide 30g, burnt sugar coloring
1.44kg, potassium sorbate 72g.
Preparation method: by the soft capsule content formula of the soft capsule B with function of physical fatigue alleviation of the present embodiment
With soft capsule skin doses, according to preparation method described in embodiment 1, prepare the soft capsule B with function of physical fatigue alleviation.
Embodiment 3: there is the soft capsule C of function of physical fatigue alleviation
Soft capsule content formula: Radix Ginseng extract 4.5kg, Radix Astragali extract 6kg, Herba Epimedii extract 5.004kg, wheat
Winter extract 18kg, soybean oil 60.576kg, Cera Flava 1.92kg.
Soft capsule skin doses: gelatin 36kg, glycerol 14.4kg, purified water 36kg, titanium dioxide 45g, burnt sugar coloring
2.16kg, potassium sorbate 48g.
Preparation method: by the soft capsule content formula of the soft capsule C with function of physical fatigue alleviation of the present embodiment
With soft capsule skin doses, according to preparation method described in embodiment 1, prepare the soft capsule C with function of physical fatigue alleviation.
Embodiment 4: toxicological experiment
Soft capsule A～C to embodiments of the invention 1～embodiment 3 preparation with function of physical fatigue alleviation is carried out
Toxicological assessment is tested.
Have soft capsule A～C human oral's recommended amounts of function of physical fatigue alleviation be every day 4.8g (be converted into content
Content), adult's body weight is pressed 60kg and is calculated, equivalent dosage 0.08g/kg bw.
Laboratory animal and condition: SPF level Kunming mouse, SD rat and feedstuff are by the Changsha sky limited public affairs of duty biotechnology
Department provides, laboratory animal production licence number SCXK (Hunan) 2009-0012.Experiment condition is barrier environment, tests during experiment
Ambient temperature 22 DEG C～24 DEG C, humidity 52%～56%, laboratory animal uses credit number to be SYXK (Hunan) 2010-0011.
Under this laboratory condition, the soft capsule A～C content with function of physical fatigue alleviation is carried out following respectively
Toxicological experiment, result is as follows:
1. acute oral toxicity test: maximum tolerated dose (MTD) female to Kunming kind, male mice is more than 22.40g/
Kg bw, belongs to nontoxic level.
2. three genetic toxicity tests: Salmonella reversion test, mice bone marrow micronucleus, mouse sperm deformity
Result of the test is feminine gender.
3.30 days feeding trials: with 2.00g/kg bw, 4.00g/kg bw, 8.00g/kg bw dosage there is alleviation
The soft capsule A of physical fatigue function～C content were to rat oral gavage 30 days, and during experiment, animal growth is good, each dosage
Group body weight, weightening finish, food utilization, routine blood indexes, blood biochemistry index, organ weights and internal organs/body weight ratio and matched group
Relatively, there was no significant difference (P > 0.05).Gross anatomy has no the abnormal change the most relevant with sample with tissue pathology checking.
Illustrate that the soft capsule A with function of physical fatigue alleviation～C content are fed for 30 days and rat is had no obvious toxic-side effects.
Embodiment 5: function of physical fatigue alleviation zoopery
1 material and method
1.1 samples: have soft capsule A people's oral recommended dose of function of physical fatigue alleviation be every day 4.8g (be converted into
Content content), adult's body weight is pressed 60kg and is calculated, equivalent dosage 0.08g/kg bw.
1.2 laboratory animals and packet: SPF level Male Kunming strain mice 160, body weight is 18g-22g, diligent by Changsha sky
Bioisystech Co., Ltd provides, and laboratory animal production licence number is SCXK (Hunan) 2009-0012, and feedstuff is carried by same unit
Supply.Animal is divided into the big group of I, II, III, IV 4,40 animals of every big group, carry out respectively swimming with a load attached to the body experiment, serum urea,
Blood lactase acid and hepatic glycogen measure.Every big group is randomly divided into again matched group, basic, normal, high dosage group, often 10 mices of group.
1.3 experiment conditions: for barrier environment.Temperature 23 DEG C～24 DEG C during experiment, humidity 50%～56%, laboratory animal
Use credit number is SYXK (Hunan) 2010-0011.
1.4 dosage choice and sample treatment: according to human oral's recommended amounts, setting tool has the soft capsule of function of physical fatigue alleviation
The basic, normal, high dosage of A content is respectively 0.40g/kg bw, 0.80g/kg bw, 2.40g/kg bw (are respectively equivalent to people
The 5 of body recommended dose, 10,30 times).During test, take respectively have function of physical fatigue alleviation soft capsule A content 8.00g,
16.00g, 48.00g add vegetable oil to 200mL, by 0.1mL/10g bw volume to mouse stomach, once a day, continuous gavage
30 days.Matched group gavage gives isopyknic vegetable oil.
1.5 key instruments, equipment and reagent: animal is weighed balance, electronic balance, centrifuge, cell crushing instrument, water-bath
Case, agitator, BECKMAN COULTER AU680 automatic clinical chemistry analyzer, SBA40C bio-sensing analyser, 722 light splitting
Photometer, swimming trunk (size about 53cm × 40cm × 35cm), sheet lead, timer, hemoglobin pipet, sample injector, pipette, examination
Pipe.
Serum urea testing cassete, is provided by Shanghai Foxing Changzheng medical science Co., Ltd；Hepatic glycogen testing cassete, by Nanjing
Build up Bioengineering Research Institute to provide.
1.6 experimental techniques:
1.6.1 Loaned swimming test
After last is to mice tested material 30min, it is placed in swimming trunk went swimming, the depth of water about 30cm, water temperature 25 DEG C ± 1.0 DEG C,
The sheet lead of rat-tail root load 5% body weight.Record mice starts to the dead time as walking weight load (s) from swimming.
Swimming time is measurement data, if tested material group swimming time is considerably longer than matched group swimming time, and difference have significance (P <
0.05), can determine that this tested material has the effect extending the mice burden swimming time.
1.6.2 serum urea measures
After last is to mice tested material 30min, not swimming with a load attached to the body 90min in the water that temperature is 30 DEG C, after rest 60min
Pull out eyeball blood sampling.2000 revs/min of centrifugal 15min after standing 3h in 4 DEG C, take serum automatic clinical chemistry analyzer and measure serum urine
Element.
The data obtained is measurement data, if tested material group serum urea content is significantly lower than matched group, and difference has significantly
Property (P < 0.05), can determine that this tested material is reduced the effect that tired mice carbamide produces.
1.6.3 hepatic glycogen measures: anthrone method
After last is to mice tested material 30min, put to death animal, take liver and blot with filter paper after normal saline rinses, claim
Taking liver 100mg, remaining operations carries out hepatic glycogen mensuration by test kit description.
The data obtained is measurement data, if tested material group hepatic glycogen content is apparently higher than matched group, and difference has significance
(P < 0.05), can determine that this tested material has the effect promoting mice liver glycogen reserves.
1.6.4 blood lactase acid measures
Last is taken a blood sample 20 μ L from angular vein clump after giving tested material 30min, does not the most bear a heavy burden at the water that temperature is 30 DEG C
Stopping after went swimming 10min, after motion, 0min and 20min ibid takes a blood sample 20 μ L, measures blood lactase acid, calculates blood lactase acid bent
Area under line.
Blood lactase acid area under curve=1/2 × (the blood lactase acid value of 0min after blood lactase acid value+swimming before swimming) × 10+
1/2 × (the blood lactase acid value of rest 20min after the blood lactase acid value+swimming of 0min after swimming) × 20
The data obtained is measurement data, if tested material group Mouse Blood lactic acid area under curve is significantly lower than matched group and poor
Different have significance (P < 0.05), can determine that this tested material has the effect reducing Mouse Blood lactic acid area under curve.
1.7 Data Processing in Experiment
Statistical analysis is carried out with Spss11.0 software.During analysis, first data are carried out homogeneity test of variance, if variance is neat,
Using one factor analysis of variance totally to compare, finding differences carries out multiple dosage group by Dunnett method again and compares with one
Comparing two-by-two between group mean.If heterogeneity of variance, then initial data is carried out suitable variable conversion, meets homogeneity test of variance
After, add up by the data after conversion: if being still not up to the purpose that variance is neat after variable conversion, using rank test instead and uniting
Meter, finds overall the most variant, then use the Tamhane's T2 inspection not requiring homogeneity of variance to compare two-by-two.
1.8 results judge
Loaned swimming test result is positive, and appoints binomial index in blood lactase acid, serum urea, three biochemical indicators of hepatic glycogen
The positive, i.e. can determine that this tested material has the effect of function of physical fatigue alleviation.
2 results
2.1 have the impact on Mouse Weight of the soft capsule A content of function of physical fatigue alleviation
Being shown in Table 1-4, each dosage group mouse experiment is initial, body weight in mid-term, whole opisthosoma are heavy compared with matched group, poor without significance
Different (P > 0.05).
Table 1 has the soft capsule A content impact (I group-swimming with a load attached to the body) on Mouse Weight of function of physical fatigue alleviation
Table 2 has the soft capsule A content impact (II group-serum urea on Mouse Weight of function of physical fatigue alleviation
Measure)
Table 3 has soft capsule A content impact (III group-blood lactase acid survey on Mouse Weight of function of physical fatigue alleviation
Fixed)
Table 4 has the soft capsule A content of function of physical fatigue alleviation, and on the impact of Mouse Weight, (IV group-hepatic glycogen contains
It is fixed to measure)
2.2 have the impact on the mice burden swimming time of the soft capsule A content of function of physical fatigue alleviation
It is shown in Table 5.The high dose group mice burden swimming time compares prolongation with matched group, difference have significance (P <
0.05)。
Table 5 has the impact on the mice burden swimming time of the soft capsule A content of function of physical fatigue alleviation
2.3 have the impact on mice serum carbamide of the soft capsule A content of function of physical fatigue alleviation
It is shown in Table 6.High dose group mice serum carbamide is less than matched group (P < 0.05).
Table 6 has the impact on tired mice serum carbamide of the soft capsule A content of function of physical fatigue alleviation
2.4 have the soft capsule A content of function of physical fatigue alleviation to the impact of Mouse Blood lactic acid change after motion
It is shown in Table 7.Each dosage group Mouse Blood lactic acid area under curve compares with matched group, no significant difference (P > 0.05).
Table 7 has the soft capsule A content of function of physical fatigue alleviation to the change impact of Mouse Blood lactic acid
2.5 have the impact on Mouse Liver glycogen storage level of the soft capsule A content of function of physical fatigue alleviation
It is shown in Table 8.The liver glycogen reserves amount of high dose group mice is apparently higher than matched group, and difference has significance (P < 0.05).
Table 8 has the impact on Mouse Liver glycogen storage level of the soft capsule A content of function of physical fatigue alleviation
3 brief summaries
Under this laboratory condition, per os gives mice 0.40g/kg bw, 0.80g/kg bw, 2.40g/kg bw dosage
The soft capsule A content with function of physical fatigue alleviation 30 days, 2.40g/kg bw dosage can be obviously prolonged the negative of mice
Serum urea level after weight swimming time, increase Mouse Liver glycogen storage level, reduction mouse movement, has with matched group comparing difference
Significance (P < 0.05).Mouse Blood lactic acid area under curve is had no and significantly affects (P > 0.05) by each dosage.Illustrate the present invention's
The soft capsule A content with function of physical fatigue alleviation has function of physical fatigue alleviation.
Embodiment 2, embodiment 3 soft capsule B, the C with function of physical fatigue alleviation content through carry out alleviate body
Power fatigue function zoopery also draws same conclusions.
Claims (8)
1. a health composition with function of physical fatigue alleviation, it is characterised in that containing Radix Ginseng extract, astragalus extraction
Thing, Herba Epimedii extract, Radix Ophiopogonis extract, soybean oil and Cera Flava.
The health composition with function of physical fatigue alleviation the most according to claim 1, it is characterised in that by weight
Meter, contains: Radix Ginseng extract 30-45 part, Radix Astragali extract 40-60 part, Herba Epimedii extract 33.36-50.04 part, Radix Ophiopogonis carry
Take thing 120-180 part, soybean oil 403.84-605.76 part and Cera Flava 12.8-19.2 part.
3. there is a soft capsule for function of physical fatigue alleviation, including soft capsule content and soft capsule skin, it is characterised in that
By weight, soft capsule content contains: Radix Ginseng extract 30-45 part, Radix Astragali extract 40-60 part, Herba Epimedii extract
33.36-50.04 part, Radix Ophiopogonis extract 120-180 part, soybean oil 403.84-605.76 part and Cera Flava 12.8-19.2 part, flexible glue
Capsule skin contains: gelatin 240-360 part, glycerol 96-144 part, purified water 240-360 part, titanium dioxide 0.3-0.45 part, burnt sugar coloring
14.4-21.6 part and potassium sorbate 0.48-0.72 part.
The soft capsule with function of physical fatigue alleviation the most according to claim 3, it is characterised in that by weight,
Soft capsule content contains: Radix Ginseng extract 37.5 parts, Radix Astragali extract 50 parts, Herba Epimedii extract 41.7 parts, Radix Ophiopogonis extract
Thing 150 parts, soybean oil 504.8 parts and 16 parts of Cera Flava, soft capsule skin contains: 300 parts of gelatin, glycerol 120 parts, purified water 300 parts,
Titanium dioxide 0.375 part, burnt sugar coloring 18 parts and potassium sorbate 0.60 part.
5. the preparation method of the soft capsule with function of physical fatigue alleviation described in a claim 3, it is characterised in that bag
Include following steps:
A. glue liquid: the weight portion as described in claim 3 weighs each component of soft capsule skin, each component is mixed, and heats and stirs
Mixing uniformly, obtain glue after evacuation bubble removing, filter, stand, the glue after being filtered is standby；
Soft capsule content the most processed: the weight portion as described in claim 3 weighs each component of soft capsule content, each component is mixed
Close, heat and stir, obtaining soft capsule content；
C. the glue after the soft capsule content prepared, filtration is pressed into soft capsule in soft capsule forming machine, sizing, dry
Dry, select ball, obtain the soft capsule with function of physical fatigue alleviation.
Preparation method the most according to claim 5, it is characterised in that comprise the following steps:
A. glue liquid:
1) colloidal sol: the weight portion as described in claim 3 weighs each component of soft capsule skin, is first mixed with qs glycerin by titanium dioxide
Close, cross colloid mill Automatic Cycle and be ground to mix homogeneously, obtain mixed liquor；Burnt sugar coloring, potassium sorbate are dissolved in appropriate purified water
In, then input glue tank together with described mixed liquor, residue purified water, residue glycerol, heat and stir, in glue tank to be changed
Temperature reaches 70-75 DEG C, puts into gelatin, and under the conditions of temperature is less than 75 DEG C, insulated and stirred is until gelatin all dissolves, and obtains glue
Liquid mixture material；
2) evacuation: under the conditions of temperature is less than 75 DEG C, glue mixed material is evacuated to glue bubble-free, gelatin viscosity
18000-30000mpa, venting, obtain glue；
3) filtering, stand: by glue through 120 mesh net filtrations, the glue after filtration keeps 50-70 DEG C and stands more than 2 hours, standby
With；
Soft capsule content the most processed: the weight portion as described in claim 3 weighs each component of soft capsule content, first by Cera Flava and
Appropriate soybean oil is heated to 65-75 DEG C, and stirring is dissolved completely to Cera Flava, obtains oily wax mixture；Take residue soybean oil again, add
Described oily wax mixture stirs, and adds and extracts Radix Ginseng extract, Radix Astragali extract, Herba Epimedii extract and Radix Ophiopogonis
Thing, stirs to mix homogeneously, crosses a colloid mill, obtain soft capsule content；
C. pelleting, sizing:
1) pelleting: the glue after soft capsule content, filtration is pressed in soft capsule forming machine soft capsule, and ambient temperature is
18-26 DEG C, relative humidity be less than 35%, keeping rotating speed is that 2.0-3.5 turns/min, and sprinkler body temperature keeps 36-48 DEG C, and rubber is thick
Degree is 0.65-0.85mm；
2) sizing: the soft capsule pressed 18-26 DEG C, relative humidity be to shape under conditions of less than 35%；
D. be dried: by the soft capsule after sizing 20-25 DEG C, under conditions of relative humidity is less than 35%, aeration-drying is also fitted
Time stir；
E. ball is selected: examined on lamp inspection desk by dried soft capsule and remove underproof soft capsule, obtain that there is alleviating physical fatigue
The soft capsule of function.
Preparation method the most according to claim 6, it is characterised in that the evacuation of described step a, its vacuum is-
0.08Mpa。
8. described in claim 1 or 2, there is the tool described in the health composition of function of physical fatigue alleviation, claim 3 or 4
There is the soft capsule of function of physical fatigue alleviation for preparing the application of health food for relieving physical fatigue.
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Application publication date: 20161109 |