CN108210866A - Composition with invigorating the spleen to clear away damp pathogen effect and preparation method thereof - Google Patents
Composition with invigorating the spleen to clear away damp pathogen effect and preparation method thereof Download PDFInfo
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- CN108210866A CN108210866A CN201810031068.4A CN201810031068A CN108210866A CN 108210866 A CN108210866 A CN 108210866A CN 201810031068 A CN201810031068 A CN 201810031068A CN 108210866 A CN108210866 A CN 108210866A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/06—Fungi, e.g. yeasts
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Abstract
The present invention relates to a kind of composition with invigorating the spleen to clear away damp pathogen effect and preparation method thereof, raw material components by weight, including：1~3 parts by weight of almond, 1~3 parts by weight of campanulaceae, 3~5 parts by weight of Poria cocos, 3~5 parts by weight of adlay, 3~5 parts by weight of Semen Lablab Album, 4~6 parts by weight of Chinese yam, 4~6 parts by weight of lotus seeds, 0.5~3 parts by weight of fructus amomi, 0.5~3 parts by weight of tsaoko, 4~6 parts by weight of dried orange peel, 1~3 parts by weight of 4~6 parts by weight of malt, 4~6 parts by weight of hawthorn and Radix Glycyrrhizae.The present invention extracts active constituent and the composition being refining to obtain, the effect with invigorating the spleen to clear away damp pathogen, safe without toxic side effect by being formulated based on the plurality of raw materials such as selected almond, campanulaceae, Poria cocos and adlay；Easy to use, cost is relatively low, has good commercial promise.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and in particular to a kind of composition and its preparation side with invigorating the spleen to clear away damp pathogen effect
Method.
Background technology
Moisture weight, be common in summer and autumn friendship heat and rainy season.Humid etiology and pathogenesis mainly includes two aspects：
(1) diseases caused by external factors are cold and cool：Climate change, present people’s lives custom are bad, do not pay attention to adding clothing warming, and rainy day drenches with rain, wash in the morning
Bath, hair washing, aqueous vapor is not dry just outgoing, and transition relies on the factors such as air-conditioning, and wind-cold damp pathogen is caused to invade human body, and humid people is more next
It is more；(2) modern's eating habit is bad, weight taste, fatness, sweet, thick and oily, spicy pungent dry product eat it is more, accidental injury taste, lead to spleen
Stomach function is weak, and transportation and transformation of water and food is not normal, lacks movement in addition, and weakness of the spleen and the stomach, movement is few, in moisture entrapment body.However, existing city
For clearing damp product on face mainly based on meal replacement powder, meal replacement powder is un-extracted, and food therapy effect is not notable, and takes inconvenience,
It is not suitable for taking for a long time, it is impossible to meet the needs of user.
Invention content
For the defects in the prior art, present invention aims at provide a kind of composition with invigorating the spleen to clear away damp pathogen effect and
Preparation method, by being formulated based on the plurality of raw materials such as selected almond, campanulaceae, Poria cocos and adlay, extraction active constituent is simultaneously
The composition being refining to obtain has the effect of invigorating the spleen to clear away damp pathogen, safe without toxic side effect；Easy to use, cost is relatively low, has fine
Commercial promise.
To achieve the above object, technical solution provided by the invention is：
In a first aspect, the present invention provides a kind of composition with invigorating the spleen to clear away damp pathogen effect, raw material components by weight,
Including：1~3 parts by weight of almond, 1~3 parts by weight of campanulaceae, 3~5 parts by weight of Poria cocos, 3~5 parts by weight of adlay, 3~5 weight of Semen Lablab Album
Measure part, 4~6 parts by weight of Chinese yam, 4~6 parts by weight of lotus seeds, 0.5~3 parts by weight of fructus amomi, 0.5~3 parts by weight of tsaoko, dried orange peel 4~6
Parts by weight, 1~3 parts by weight of 4~6 parts by weight of malt, 4~6 parts by weight of hawthorn and Radix Glycyrrhizae.It should be noted that campanulaceae, apricot in side
Benevolence facilitaing lung relieving sore-throat, expelling phlegm and arresting coughing, can Xuanhua be stranded in the phlegm wet of lung and the throat part of the body cavity above the diaphragm housing the heart and lungs；Tsaoko, fructus amomi, dried orange peel eliminating dampness middle benefit gas,
It removes dampness by means of aromatics, regulating qi-flowing for strengthening spleen, hawthorn, malt relieving dyspepsia can strengthen gastrointestinal peristalsis, and the collocation of five medicines can be dissolved and be stranded in taste
It is middle burnt wet turbid；Poria cocos, adlay, the infiltration of Semen Lablab Album dampness removing, invigorating spleen to remove dampness, regulating fluid apssage can allow and be stranded under kidney and bladder
Burnt humidity hysteresis is solved by lower, and lotus seeds Chinese yam tonifying spleen nourishing the stomach, replenish qi to invigorate the spleen, earth up anti-overflow, Radix Glycyrrhizae tonifying middle-Jiao and Qi, coordinating the drug actions of a prescription, all medicines
Compatibility can enable the phlegm wet of the delay part of the body cavity above the diaphragm housing the heart and lungs declare hair, stagnate that lower burnt water is wet to ooze profit by down, burnt wet turbid by up or down in retardance
Neutralizing, then coordinate and replenish qi to invigorate the spleen, anti-overflow ingredient of earthing up, the regeneration of internal damp evil, up/down perforation are reduced, humidity hysteresis must solve, and mend thin simultaneous
It cares for, treating both manifestation and root cause of disease, actually the side of rare invigorating the spleen to clear away damp pathogen.
Preferably, the raw material components of the composition with invigorating the spleen to clear away damp pathogen effect further include：0.5~3 parts by weight of ginseng, wrinkled giant hyssop
1~3 parts by weight, 0.5~3 parts by weight of jujube, 0.5~3 parts by weight of 1~3 parts by weight of ginger, 3~5 parts by weight of sealwort and Chinese cassia tree.
Preferably, the raw material components of the composition with invigorating the spleen to clear away damp pathogen effect further include：3~5 parts by weight of lotus leaf, reed root 4
~6 parts by weight, 1~3 parts by weight of honeysuckle, 1~3 parts by weight of dandelion, 3~5 parts by weight of lophatherum gracile, 1~3 parts by weight of peppermint and
4~6 parts by weight of pueraria lobata.
Preferably, the raw material components of the composition with invigorating the spleen to clear away damp pathogen effect further include：1~3 parts by weight of cassia twig, Rhizoma Atractylodis Macrocephalae 3
~5 parts by weight, 3~5 parts by weight of rhizoma atractylodis, 3~5 parts by weight of Cortex Magnoliae Officinalis, 1~3 parts by weight of purple perilla, 1~3 parts by weight of the root of Dahurain angelica and elscholtiza 3
~5 parts by weight.
Preferably, the raw material components of the composition with invigorating the spleen to clear away damp pathogen effect further include：4~6 parts by weight of plantain seed, rhizoma alismatis
4~6 parts by weight, 3~5 parts by weight of Cortex Phellodendri, 3~5 parts by weight of rhizoma atractylodis, 0.5~3 parts by weight of Chinese cassia tree, 3~5 parts by weight of umbellate pore furgus and white
4~6 parts by weight of art.
Second aspect, the present invention provides the preparation method of the composition with invigorating the spleen to clear away damp pathogen effect, including step：S1：
It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；S2：By almond, campanulaceae, Poria cocos, adlay, white flat
Beans, dried orange peel, malt and Radix Glycyrrhizae carry out decoction extraction with water, and after extraction, the first filtrate and the first filter are collected in filtering respectively
Slag；S3：First filter residue and other surplus stock components are uniformly mixed, then add in ethanol water, adjust pH value to 6.0~
6.3, impregnate preset time；Then it is 8.0~8.2 to adjust pH value, then carries out refluxing extraction；After extraction, filtering collects the
Two filtrates；S4：First filtrate and the second filtrate are merged, then heating concentration, obtains medicinal extract；S5：By mixed-powder and medicinal extract
It dries after mixing, then crushes, is sieved, collect fine powder, obtain composition.
In step S2, the number for decocting extraction is 2~4 times, and the time for decocting extraction every time is 1.5~2.5h；It carries every time
When taking, the quality of water is 10~12 times of almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and the gross mass of Radix Glycyrrhizae.
In step S3, the addition quality of ethanol water is the 5 of the first filter residue and the gross mass of other surplus stock components
~7 times, in ethanol water, the volume fraction of ethyl alcohol is 55%~60%；The time of immersion is 6~8h, and the temperature of immersion is
60~70 DEG C；The time of refluxing extraction is 1~1.5h.
In step S4, medicinal extract is 1.2~1.25 in the relative density of 25 DEG C of measure；It is dry to be dried under reduced pressure in step S5,
Dry temperature is not higher than 60 DEG C.
The third aspect, the present invention also application of the protection above-mentioned composition in invigorating the spleen to clear away damp pathogen product is prepared.
It should be noted that the eating method of the composition with invigorating the spleen to clear away damp pathogen effect that the present invention is prepared is preferred
For：Edible 10~20g (can directly take orally, mixing in water for oral taking can also be used) every time, it is 1 time edible daily；Edible time can basis
The state of an illness is adjusted.
Composition prepared by the above method can be further prepared into pharmaceutically acceptable dosage form as needed.In addition, with
Above-mentioned composition also belongs to protection scope of the present invention for drug made of active constituent.By by aforementioned pharmaceutical compositions, directly
It connects preparation or is prepared after adding in pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable dosage form.With external application system
Include for agent：Solution, patch, vina, tincture, gelling agent, liniment, aerosol, spray, ointment and plastics.On
Stating the drug of various dosage forms can prepare according to the conventional method of pharmaceutical field.
Technical solution provided by the invention has following advantageous effect：(1) present invention using traditional Chinese medicine food therapy theory as according to
According to being formulated based on the plurality of raw materials such as selected almond, campanulaceae, Poria cocos and adlay, with modern advanced technology, extract plant
The composition that active constituent is refining to obtain has the effect of invigorating the spleen to clear away damp pathogen, is suitble to take for a long time, and without side-effects；(2) it is of the invention
According to the principle of reatment of differentiation of tcm, according to the difference of disease, on the basis of basic components, ginseng, wrinkled giant hyssop, big is added in
Jujube, ginger, sealwort and Chinese cassia tree can enhance the effect of replenishing qi to invigorate the spleen, is warming cold-damp, be conducive to the crowd of weakness of the spleen and the stomach cold-dampness weight
It takes；(3) present invention, according to the difference of disease, on the basis of basic components, adds according to the principle of reatment of differentiation of tcm
Enter lotus leaf, reed root, honeysuckle, dandelion, lophatherum gracile, peppermint and pueraria lobata, clearing heat and promoting diuresis, clearing heat and detoxicating ingredient can be increased, had
Crowd conducive to dampness-heat in upper jiao weight takes；(4) present invention is according to the principle of reatment of differentiation of tcm, according to the difference of disease,
On the basis of basic components, add in cassia twig, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, Cortex Magnoliae Officinalis, purple perilla, the root of Dahurain angelica and elscholtiza, can increase remove dampness by means of aromatics,
The wide middle ingredient of promoting the circulation of qi, for middle coke, wet turbid heavy crowd takes；(5) present invention is according to the principle of reatment of differentiation of tcm, root
According to the difference of disease, on the basis of basic components, plantain seed, rhizoma alismatis, Cortex Phellodendri, rhizoma atractylodis, Chinese cassia tree, umbellate pore furgus and Rhizoma Atractylodis Macrocephalae are added in, it can
To increase heat-clearing and damp-drying drug and reducing fever and causing diuresis ingredient, the crowd for damp-heat in lower-JIAO weight takes；(6) it is provided by the invention that there is invigorating the spleen
The preparation method of the composition of clearing damp effect, by lotus seeds, Chinese yam mixes fructus amomi, tsaoko beats powder, makes full use of lotus seeds and Chinese yam rich
Amyloid characteristic can substitute and crush tsaoko, other auxiliary materials (starch, dextrin) that fructus amomi fragrance drug needs add, not only
Retain effective component aromatic lipid phase very well, the dosage of auxiliary material (starch, dextrin) can also be reduced, improve curative effect.(7) this hair
Part material is carried out decoction extraction by the preparation method of the composition with invigorating the spleen to clear away damp pathogen effect of bright offer using water first,
Filter residue and other surplus stocks are mixed again, are impregnated successively in different pH value and alcohol extracting, so as to more favorable extraction
Active ingredient in raw material improves the drug effect for the composition being prepared.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
It obtains significantly or is recognized by the practice of the present invention.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme of the present invention is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme of the present invention, therefore be intended only as example, and cannot limit this hair with this
Bright protection domain.
Experimental method in following embodiments is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following embodiment, is respectively provided with three
Secondary to repeat to test, data are the average value or mean+SD of three repeated experiments.
Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, lotus seeds, fructus amomi, tsaoko, dried orange peel, wheat used in following embodiments
Bud, hawthorn, Radix Glycyrrhizae, ginseng, wrinkled giant hyssop, jujube, sealwort, Chinese cassia tree, lotus leaf, reed root, honeysuckle, dandelion, lophatherum gracile, peppermint, Pueraria lobota
Root, cassia twig, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, Cortex Magnoliae Officinalis, purple perilla, the root of Dahurain angelica, elscholtiza, plantain seed, rhizoma alismatis, Cortex Phellodendri and umbellate pore furgus meet Chinese Pharmacopoeia
Pertinent regulations under (version in 2015) each medicinal material item of text.Before feeding intake, by identification, ingredients material object and title phase
Symbol, quality comply with standard.
The present invention provides a kind of composition with invigorating the spleen to clear away damp pathogen effect, raw material components by weight, including：Almond 1
~3 parts by weight, 1~3 parts by weight of campanulaceae, 3~5 parts by weight of Poria cocos, 3~5 parts by weight of adlay, 3~5 parts by weight of Semen Lablab Album, Chinese yam 4
~6 parts by weight, 4~6 parts by weight of lotus seeds, 0.5~3 parts by weight of fructus amomi, 0.5~3 parts by weight of tsaoko, 4~6 parts by weight of dried orange peel, wheat
1~3 parts by weight of 4~6 parts by weight of bud, 4~6 parts by weight of hawthorn and Radix Glycyrrhizae.
Preferably, the raw material components of composition further include：0.5~3 parts by weight of ginseng, 1~3 parts by weight of wrinkled giant hyssop, jujube 0.5
~3 parts by weight, 0.5~3 parts by weight of 1~3 parts by weight of ginger, 3~5 parts by weight of sealwort and Chinese cassia tree.
Preferably, the raw material components of composition further include：3~5 parts by weight of lotus leaf, 4~6 parts by weight of reed root, honeysuckle 1~
3 parts by weight, 1~3 parts by weight of dandelion, 4~6 parts by weight of 3~5 parts by weight of lophatherum gracile, 1~3 parts by weight of peppermint and pueraria lobata.
Preferably, the raw material components of composition further include：1~3 parts by weight of cassia twig, 3~5 parts by weight of Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis 3~5
Parts by weight, 3~5 parts by weight of Cortex Magnoliae Officinalis, 3~5 parts by weight of 1~3 parts by weight of purple perilla, 1~3 parts by weight of the root of Dahurain angelica and elscholtiza.
Preferably, the raw material components of composition further include：4~6 parts by weight of plantain seed, 4~6 parts by weight of rhizoma alismatis, Cortex Phellodendri 3~
5 parts by weight, 3~5 parts by weight of rhizoma atractylodis, 4~6 parts by weight of 0.5~3 parts by weight of Chinese cassia tree, 3~5 parts by weight of umbellate pore furgus and Rhizoma Atractylodis Macrocephalae.
In addition, the present invention also provides the preparation method of the above-mentioned composition with invigorating the spleen to clear away damp pathogen effect, including walking as follows
Suddenly：
S1：It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；
S2：Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and Radix Glycyrrhizae with water decoct and extract 2~4
Secondary, the time for decocting extraction every time is 1.5~2.5h；Every time during extraction, the quality of water is almond, campanulaceae, Poria cocos, adlay, white
Hyacinth bean, dried orange peel, 10~12 times of malt and the gross mass of Radix Glycyrrhizae；It filters after extraction, is filtered after extracting every time every time
Obtained filtrate merges, and obtains the first filtrate, and it is the first filter residue to collect the filter residue being obtained by filtration after last time is extracted；
S3：First filter residue and other surplus stock components are uniformly mixed, it is 55%~60% then to add in volume fraction
Ethanol water, the addition quality of ethanol water is the 5~7 of the first filter residue and the gross mass of other surplus stock components
Times, pH value is adjusted to 6.0~6.3,60~70 DEG C of 6~8h of immersion；Then it is 8.0~8.2 to adjust pH value, then refluxing extraction 1~
1.5h；After extraction, the second filtrate is collected in filtering；
S4：First filtrate and the second filtrate are merged, then heating concentration, the relative density for obtaining measuring at 25 DEG C is
1.2~1.25 medicinal extract；
S5：Mixed-powder and medicinal extract are dried under reduced pressure after mixing, dry temperature is not higher than 60 DEG C, then crush,
Sieving collects fine powder, obtains composition.
With reference to specific embodiment to composition provided by the invention with invigorating the spleen to clear away damp pathogen effect and preparation method thereof
It is described further.
Embodiment one
The present embodiment provides a kind of composition with invigorating the spleen to clear away damp pathogen effect, raw material components by weight, including：Almond
2 parts by weight, 2 parts by weight of campanulaceae, 4 parts by weight of Poria cocos, 4 parts by weight of adlay, 4 parts by weight of Semen Lablab Album, 5 parts by weight of Chinese yam, 5 weight of lotus seeds
Measure part, 2.5 parts by weight of fructus amomi, 1.5 parts by weight of tsaoko, 5 parts by weight of dried orange peel, 2 weight of 5 parts by weight of malt, 5 parts by weight of hawthorn and Radix Glycyrrhizae
Measure part.
By above-mentioned raw material, using preparation method provided by the invention, the composition with invigorating the spleen to clear away damp pathogen effect is prepared：
S1：It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；
S2：Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and Radix Glycyrrhizae are subjected to decoction extraction 3 times with water, often
The secondary time for decocting extraction is 2h；Every time during extraction, the quality of water is almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, wheat
11 times of the gross mass of bud and Radix Glycyrrhizae；It is filtered after extraction every time, the filtrate being obtained by filtration after each extraction is merged, is obtained
To the first filtrate, and it is the first filter residue to collect the filter residue being obtained by filtration after last time is extracted；
S3：First filter residue and other surplus stock components are uniformly mixed, then add in the ethyl alcohol that volume fraction is 55%
Aqueous solution, the addition quality of ethanol water are 6 times of the first filter residue and the gross mass of other surplus stock components, adjust pH value
To 6.1,65 DEG C of immersion 7h；Then it is 8.1 to adjust pH value, then refluxing extraction 1.2h；After extraction, the second filter is collected in filtering
Liquid；
S4：First filtrate and the second filtrate are merged, then heating concentration, the relative density for obtaining measuring at 25 DEG C is
1.2 medicinal extract；
S5：Mixed-powder and medicinal extract are dried under reduced pressure after mixing, dry temperature is 55 DEG C, then crushes, is sieved,
Fine powder is collected, obtains composition.
Embodiment two
The present embodiment provides a kind of composition with invigorating the spleen to clear away damp pathogen effect, raw material components by weight, including：Almond
2 parts by weight, 2 parts by weight of campanulaceae, 4 parts by weight of Poria cocos, 4 parts by weight of adlay, 4 parts by weight of Semen Lablab Album, 5 parts by weight of Chinese yam, 5 weight of lotus seeds
Measure part, 2.5 parts by weight of fructus amomi, 1.5 parts by weight of tsaoko, 5 parts by weight of dried orange peel, 5 parts by weight of malt, 5 parts by weight of hawthorn, 2 weight of Radix Glycyrrhizae
Measure part, 2 parts by weight of ginseng, 2 parts by weight of wrinkled giant hyssop, 1.5 parts by weight of jujube, 2.5 weight of 2 parts by weight of ginger, 4 parts by weight of sealwort and Chinese cassia tree
Part.
By above-mentioned raw material, using preparation method provided by the invention, the composition with invigorating the spleen to clear away damp pathogen effect is prepared：
S1：It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；
S2：Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and Radix Glycyrrhizae are subjected to decoction extraction 3 times with water, often
The secondary time for decocting extraction is 2h；Every time during extraction, the quality of water is almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, wheat
11 times of the gross mass of bud and Radix Glycyrrhizae；It is filtered after extraction every time, the filtrate being obtained by filtration after each extraction is merged, is obtained
To the first filtrate, and it is the first filter residue to collect the filter residue being obtained by filtration after last time is extracted；
S3：First filter residue and other surplus stock components are uniformly mixed, then add in the ethyl alcohol that volume fraction is 55%
Aqueous solution, the addition quality of ethanol water are 6 times of the first filter residue and the gross mass of other surplus stock components, adjust pH value
To 6.1,65 DEG C of immersion 7h；Then it is 8.1 to adjust pH value, then refluxing extraction 1.2h；After extraction, the second filter is collected in filtering
Liquid；
S4：First filtrate and the second filtrate are merged, then heating concentration, the relative density for obtaining measuring at 25 DEG C is
1.2 medicinal extract；
S5：Mixed-powder and medicinal extract are dried under reduced pressure after mixing, dry temperature is 55 DEG C, then crushes, is sieved,
Fine powder is collected, obtains composition.
Embodiment three
The present embodiment provides a kind of composition with invigorating the spleen to clear away damp pathogen effect, raw material components by weight, including：Almond
2 parts by weight, 2 parts by weight of campanulaceae, 4 parts by weight of Poria cocos, 4 parts by weight of adlay, 4 parts by weight of Semen Lablab Album, 5 parts by weight of Chinese yam, 5 weight of lotus seeds
Measure part, 2.5 parts by weight of fructus amomi, 1.5 parts by weight of tsaoko, 5 parts by weight of dried orange peel, 5 parts by weight of malt, 5 parts by weight of hawthorn, 2 weight of Radix Glycyrrhizae
Measure part, 4 parts by weight of lotus leaf, 5 parts by weight of reed root, 2 parts by weight of honeysuckle, 2 parts by weight of dandelion, 4 parts by weight of lophatherum gracile, peppermint 2
5 parts by weight of parts by weight and pueraria lobata.
By above-mentioned raw material, using preparation method provided by the invention, the composition with invigorating the spleen to clear away damp pathogen effect is prepared：
S1：It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；
S2：Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and Radix Glycyrrhizae are subjected to decoction extraction 3 times with water, often
The secondary time for decocting extraction is 2h；Every time during extraction, the quality of water is almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, wheat
11 times of the gross mass of bud and Radix Glycyrrhizae；It is filtered after extraction every time, the filtrate being obtained by filtration after each extraction is merged, is obtained
To the first filtrate, and it is the first filter residue to collect the filter residue being obtained by filtration after last time is extracted；
S3：First filter residue and other surplus stock components are uniformly mixed, then add in the ethyl alcohol that volume fraction is 55%
Aqueous solution, the addition quality of ethanol water are 6 times of the first filter residue and the gross mass of other surplus stock components, adjust pH value
To 6.1,65 DEG C of immersion 7h；Then it is 8.1 to adjust pH value, then refluxing extraction 1.2h；After extraction, the second filter is collected in filtering
Liquid；
S4：First filtrate and the second filtrate are merged, then heating concentration, the relative density for obtaining measuring at 25 DEG C is
1.2 medicinal extract；
S5：Mixed-powder and medicinal extract are dried under reduced pressure after mixing, dry temperature is 55 DEG C, then crushes, is sieved,
Fine powder is collected, obtains composition.
Example IV
The present embodiment provides a kind of composition with invigorating the spleen to clear away damp pathogen effect, raw material components by weight, including：Almond
2 parts by weight, 2 parts by weight of campanulaceae, 4 parts by weight of Poria cocos, 4 parts by weight of adlay, 4 parts by weight of Semen Lablab Album, 5 parts by weight of Chinese yam, 5 weight of lotus seeds
Measure part, 2.5 parts by weight of fructus amomi, 1.5 parts by weight of tsaoko, 5 parts by weight of dried orange peel, 5 parts by weight of malt, 5 parts by weight of hawthorn, 2 weight of Radix Glycyrrhizae
Measure part, 2 parts by weight of cassia twig, 4 parts by weight of Rhizoma Atractylodis Macrocephalae, 4 parts by weight of rhizoma atractylodis, 4 parts by weight of Cortex Magnoliae Officinalis, 2 parts by weight of purple perilla, 2 parts by weight of the root of Dahurain angelica
With 4 parts by weight of elscholtiza.
By above-mentioned raw material, using preparation method provided by the invention, the composition with invigorating the spleen to clear away damp pathogen effect is prepared：
S1：It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；
S2：Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and Radix Glycyrrhizae are subjected to decoction extraction 3 times with water, often
The secondary time for decocting extraction is 2h；Every time during extraction, the quality of water is almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, wheat
11 times of the gross mass of bud and Radix Glycyrrhizae；It is filtered after extraction every time, the filtrate being obtained by filtration after each extraction is merged, is obtained
To the first filtrate, and it is the first filter residue to collect the filter residue being obtained by filtration after last time is extracted；
S3：First filter residue and other surplus stock components are uniformly mixed, then add in the ethyl alcohol that volume fraction is 55%
Aqueous solution, the addition quality of ethanol water are 6 times of the first filter residue and the gross mass of other surplus stock components, adjust pH value
To 6.1,65 DEG C of immersion 7h；Then it is 8.1 to adjust pH value, then refluxing extraction 1.2h；After extraction, the second filter is collected in filtering
Liquid；
S4：First filtrate and the second filtrate are merged, then heating concentration, the relative density for obtaining measuring at 25 DEG C is
1.2 medicinal extract；
S5：Mixed-powder and medicinal extract are dried under reduced pressure after mixing, dry temperature is 55 DEG C, then crushes, is sieved,
Fine powder is collected, obtains composition.
Embodiment five
The present embodiment provides a kind of composition with invigorating the spleen to clear away damp pathogen effect, raw material components by weight, including：Almond
2 parts by weight, 2 parts by weight of campanulaceae, 4 parts by weight of Poria cocos, 4 parts by weight of adlay, 4 parts by weight of Semen Lablab Album, 5 parts by weight of Chinese yam, 5 weight of lotus seeds
Measure part, 2.5 parts by weight of fructus amomi, 1.5 parts by weight of tsaoko, 5 parts by weight of dried orange peel, 5 parts by weight of malt, 5 parts by weight of hawthorn, 2 weight of Radix Glycyrrhizae
Measure part, 5 parts by weight of plantain seed, 5 parts by weight of rhizoma alismatis, 4 parts by weight of Cortex Phellodendri, 4 parts by weight of rhizoma atractylodis, 2 parts by weight of Chinese cassia tree, 4 weight of umbellate pore furgus
Part and 5 parts by weight of Rhizoma Atractylodis Macrocephalae.
By above-mentioned raw material, using preparation method provided by the invention, the composition with invigorating the spleen to clear away damp pathogen effect is prepared：
S1：It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；
S2：Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and Radix Glycyrrhizae are subjected to decoction extraction 3 times with water, often
The secondary time for decocting extraction is 2h；Every time during extraction, the quality of water is almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, wheat
11 times of the gross mass of bud and Radix Glycyrrhizae；It is filtered after extraction every time, the filtrate being obtained by filtration after each extraction is merged, is obtained
To the first filtrate, and it is the first filter residue to collect the filter residue being obtained by filtration after last time is extracted；
S3：First filter residue and other surplus stock components are uniformly mixed, then add in the ethyl alcohol that volume fraction is 55%
Aqueous solution, the addition quality of ethanol water are 6 times of the first filter residue and the gross mass of other surplus stock components, adjust pH value
To 6.1,65 DEG C of immersion 7h；Then it is 8.1 to adjust pH value, then refluxing extraction 1.2h；After extraction, the second filter is collected in filtering
Liquid；
S4：First filtrate and the second filtrate are merged, then heating concentration, the relative density for obtaining measuring at 25 DEG C is
1.2 medicinal extract；
S5：Mixed-powder and medicinal extract are dried under reduced pressure after mixing, dry temperature is 55 DEG C, then crushes, is sieved,
Fine powder is collected, obtains composition.
The composition with invigorating the spleen to clear away damp pathogen effect that the embodiment of the present invention one to embodiment five is prepared, passes through function
It learns experiment and carrys out system evaluation its effect.
1st, clearing damp effect
(1) collection phlegm-dampness constitution person 250.Specifically, patient is divided into 5 groups, every group 50.By first group to the 5th
Group tries out the composition that is prepared of the embodiment of the present invention one to embodiment five 4 weeks respectively, and edible 10g (can direct mouth every time
Clothes, can also use mixing in water for oral taking), it is early daily 1 time edible；Curative effect is observed later.
(2) diagnostic criteria：
A. inclusion criteria：Organic disease except being checked through comprehensive system.According to《Traditional Chinese Medicine Constitution Classification and judgement scale》
(China Association of Traditional Chinese Medicine 2009.4) is determined as phlegm-dampness constitution person, 18~55 years old age.Voluntarily receive intervening measure person.
B. exclusion criteria：It is found by comprehensive physical examination in morbid state person.Healthy population.Gestation and the woman for preparing gestation
Female, women breast-feeding their children.Suspect or truly have abuse of alcohol, drug past medical history.It is known to this medicine constituent allergy sufferers.It is participating in
The patient of other drugs clinical test.It is reluctant partner.The references such as remaining rejecting in relation to case《New Chinese medicine clinical research refers to
Lead principle》It performs.
(3) curative effect is judged as：
Comprehensive therapeutic effect carries out the qualitative pretherapy and post-treatment trade-off of sxemiquantitative mainly for related symptom.It scores by 4 grades of methods
(0=is without 2=has once in a while, and 4=often has, and 6=persistently has) calculates total mark, as shown in table 1.Using Nimodipine method, show
Effect：Most of symptom disappears after treatment, and symptom integral number, which declines, is more than or equal to 2/3；Effectively：Partial symptoms improve after treatment, disease
Shape fraction, which declines, is more than 1/3 less than 2/3；In vain：Symptom improvement unobvious after treatment, symptom integral number are dropped by less than being equal to 1/
3。
(4) observation index：
A. curative effect index, phlegm-dampness constitution subhealth symptom：Using from the phlegm-dampness constitution subhealth symptom table of integrals is intended, observation is controlled
Self-variation and itself and comparison among groups are carried out before and after treatment；
B. objective indicator：Hemorheology, one bleed inferior health detection (MDI)；
C. safety indexes：Safety indexes main detection serum TG, TC, blood, urine, stool routine examination, liver function, kidney function, together
Shi Jinhang Ecgs.
(5) efficacy result：The effect of overall, the results are shown in Table 2.
The 1 phlegm-dampness constitution subhealth symptom table of integrals of table
| Cardinal symptom | Nothing | Have once in a while | Often have | Persistently have |
| Abdominal fullness and distention | 0 | 2 | 4 | 6 |
| It is sticky in mouthful | 0 | 2 | 4 | 6 |
| Hidrosis and viscous | 0 | 2 | 4 | 6 |
| Loose stool is not well | 0 | 2 | 4 | 6 |
| Body sleepiness power | 0 | 2 | 4 | 6 |
| Limbs are heavy | 0 | 2 | 4 | 6 |
| Abundant expectoration | 0 | 2 | 4 | 6 |
The effect of 2 phlegm-dampness constitution person of table statistical form
| Group | Effective/name | Effectively/name | In vain/name | Total effective rate/% |
| Embodiment one | 36 | 10 | 4 | 92% |
| Embodiment two | 45 | 4 | 1 | 98% |
| Embodiment three | 48 | 2 | 0 | 100% |
| Example IV | 42 | 6 | 2 | 96% |
| Embodiment five | 46 | 3 | 1 | 98% |
2nd, Animal Behavior Science is tested
This research is intended wet outside Guangdong and Guangxi Provinces and the complex factors such as Hainan Region mankind's external environment and eating habit by simulating
Thermal environment, high glucose and high fat diet and pathogenic microorganism) rat phlegm wet card is caused, the change of observation phlegm wet card rat behavior is inquired into
Composition provided by the invention with invigorating the spleen to clear away damp pathogen effect is to the intervention effect of its behavior.
(1) test medicine：The composition that embodiment one is prepared to embodiment five.
(2) it is grouped：SPF grades of Wistar rats 70, half male and half female, 180~220g of weight, by digital random table method with
Machine is divided into 7 groups, every group 10, respectively control group, humidity hysteresis taste group (phlegm wet group) and test group.Phlegm wet group animal is before experiment
Fasting 12h, free water.
(3) experimental method：
A. control group：At 20-28 DEG C of temperature, 50%~60% relative humidity conditions, fed with common mixed fodder, often
Day 8:30 feed material.B. phlegm wet group：High glucose and high fat forage feed 10 days is put wherein pinpointing within the 1st day to the 8th day two hours daily
In in analogue simulation climate compartment, in cabin temperature 33 degree (33 ± 2) DEG C, relative humidity (75 ± 5) %, the 9th day 8:30 start gavage,
Strengthen infection 1 time by 1ml/200g body weights again after giving Escherichia coli 1 time, 24 hours by 2ml/200g weight, then move to
It is placed in natural environment out of my cabin.C. test group：It gives phlegm wet group similarly to handle, but from the 4th day, is removing analogue simulation
Climate compartment is placed outside the composition in natural environment after 12 hours, being prepared respectively with embodiment one to embodiment five, presses
2mg/100g body weight gavages, 1 times/day, totally 7 days.The daily behavior for observing animal, symptom, sign simultaneously record, and the results are shown in Table 1,
And spacious field experiment was carried out with the 11st day on day 3 respectively, the center lattice residence time of rat is recorded respectively, moves lattice number, is upright
Number.Estimated by Open-field behaviors, with toy behaviouristics record analysis system, observe the situation of change of animal.Knot
Fruit is shown in Table shown in 3 and table 4.
The variation of 3 center lattice residence time of table is compared
Table 4 moves the variation of lattice number and compares
3rd, toxicity test
The small white mouse 50 (each 25 of male and female) that weight is selected to be 18~22g, is divided into 5 groups, each 5 of every group of male and female fill respectively
The composition that the embodiment of the present invention one is prepared to embodiment five is taken, dosage 0.5g/kg continuously gives composition 30 days.It gives
When during composition and 1 week after withdrawing, white mouse growth conditions and activity and diet, identification hematology, blood biochemical analysis, internal organs are observed
Institutional framework and routine urinalysis etc..As a result, it has been found that the health existence of all small white mouses, without any side effects；Blood is dissected and observed
As, liver function, each organs and tissues state, the indifference compared with normal small white mouse.It is demonstrated experimentally that composition provided by the invention without
Toxic side effect.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, it otherwise illustrates in these embodiments
Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustrative, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the present invention, it is to be understood that term " first ", " second " are only used for description purpose, and cannot
It is interpreted as indicating or implies relative importance or imply the quantity of the technical characteristic indicated by indicating.Define as a result, " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the present invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe is described in detail the present invention with reference to foregoing embodiments, it will be understood by those of ordinary skill in the art that：Its according to
Can so modify to the technical solution recorded in foregoing embodiments either to which part or all technical features into
Row equivalent replacement；And these modifications or replacement, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover in protection scope of the present invention.
Claims (10)
1. a kind of composition with invigorating the spleen to clear away damp pathogen effect, which is characterized in that raw material components by weight, including：
1~3 parts by weight of almond, 1~3 parts by weight of campanulaceae, 3~5 parts by weight of Poria cocos, 3~5 parts by weight of adlay, 3~5 weight of Semen Lablab Album
Measure part, 4~6 parts by weight of Chinese yam, 4~6 parts by weight of lotus seeds, 0.5~3 parts by weight of fructus amomi, 0.5~3 parts by weight of tsaoko, dried orange peel 4~6
Parts by weight, 1~3 parts by weight of 4~6 parts by weight of malt, 4~6 parts by weight of hawthorn and Radix Glycyrrhizae.
2. the composition according to claim 1 with invigorating the spleen to clear away damp pathogen effect, which is characterized in that the raw material components also wrap
It includes：
0.5~3 parts by weight of ginseng, 1~3 parts by weight of wrinkled giant hyssop, 0.5~3 parts by weight of jujube, 1~3 parts by weight of ginger, 3~5 weight of sealwort
Measure 0.5~3 parts by weight of part and Chinese cassia tree.
3. the composition according to claim 1 with invigorating the spleen to clear away damp pathogen effect, which is characterized in that the raw material components also wrap
It includes：
3~5 parts by weight of lotus leaf, 4~6 parts by weight of reed root, 1~3 parts by weight of honeysuckle, 1~3 parts by weight of dandelion, lophatherum gracile 3~
4~6 parts by weight of 5 parts by weight, 1~3 parts by weight of peppermint and pueraria lobata.
4. the composition according to claim 1 with invigorating the spleen to clear away damp pathogen effect, which is characterized in that the raw material components also wrap
It includes：
1~3 parts by weight of cassia twig, 3~5 parts by weight of Rhizoma Atractylodis Macrocephalae, 3~5 parts by weight of rhizoma atractylodis, 3~5 parts by weight of Cortex Magnoliae Officinalis, 1~3 weight of purple perilla
Part, 3~5 parts by weight of 1~3 parts by weight of the root of Dahurain angelica and elscholtiza.
5. the composition according to claim 1 with invigorating the spleen to clear away damp pathogen effect, which is characterized in that the raw material components also wrap
It includes：
4~6 parts by weight of plantain seed, 4~6 parts by weight of rhizoma alismatis, 3~5 parts by weight of Cortex Phellodendri, 3~5 parts by weight of rhizoma atractylodis, Chinese cassia tree 0.5~3
4~6 parts by weight of parts by weight, 3~5 parts by weight of umbellate pore furgus and Rhizoma Atractylodis Macrocephalae.
6. claim 1-5 any one of them has the preparation method of the composition of invigorating the spleen to clear away damp pathogen effect, which is characterized in that packet
Include step：
S1：It is crushed after fructus amomi, tsaoko, lotus seeds and Chinese yam are mixed, obtains mixed-powder；
S2：Almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and Radix Glycyrrhizae are subjected to decoction extraction with water, extraction finishes
Afterwards, it filters, collects the first filtrate and the first filter residue respectively；
S3：First filter residue and other surplus stock components are uniformly mixed, then add in ethanol water, adjust pH value to
6.0~6.3, impregnate preset time；Then it is 8.0~8.2 to adjust pH value, then carries out refluxing extraction；After extraction, filtering,
Collect the second filtrate；
S4：First filtrate and second filtrate are merged, then heating concentration, obtains medicinal extract；
S5：The mixed-powder and the medicinal extract are dried after mixing, then crushes, are sieved, collect fine powder, is obtained described
Composition.
7. the preparation method of the composition according to claim 6 with invigorating the spleen to clear away damp pathogen effect, it is characterised in that：
In step S2, the number for decocting extraction is 2~4 times, and the time for decocting extraction every time is 1.5~2.5h；It carries every time
When taking, the quality of water is 10~12 times of almond, campanulaceae, Poria cocos, adlay, Semen Lablab Album, dried orange peel, malt and the gross mass of Radix Glycyrrhizae.
8. the preparation method of the composition according to claim 6 with invigorating the spleen to clear away damp pathogen effect, it is characterised in that：
In step S3, the addition quality of the ethanol water is the 5 of the first filter residue and the gross mass of other surplus stock components
~7 times, in the ethanol water, the volume fraction of ethyl alcohol is 55%~60%；The time of the immersion is 6~8h, described
The temperature of immersion is 60~70 DEG C；The time of the refluxing extraction is 1~1.5h.
9. the preparation method of the composition according to claim 6 with invigorating the spleen to clear away damp pathogen effect, it is characterised in that：
In step S4, the medicinal extract is 1.2~1.25 in the relative density of 25 DEG C of measure；
In step S5, to be dried under reduced pressure, the temperature of the drying is not higher than 60 DEG C for the drying.
10. application of the claim 1-5 any one of them composition in invigorating the spleen to clear away damp pathogen product is prepared.
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| CN108904742A (en) * | 2018-08-21 | 2018-11-30 | 岚皋县硒安生物科技有限公司 | A kind of clearing damp Chinese medicine composition |
| CN109350708A (en) * | 2018-12-11 | 2019-02-19 | 丛念滋 | Have effects that transport spleen dampness elimination, promoting the circulation of qi and middle herbaceous plant drink and preparation method thereof |
| CN110353064A (en) * | 2019-07-30 | 2019-10-22 | 广州致诚尚品医药科技有限公司 | In a kind of generation, makes tea drink |
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| CN113648386A (en) * | 2021-07-31 | 2021-11-16 | 云南中医药大学 | Medicinal and edible compound composition and application thereof |
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| CN109350708A (en) * | 2018-12-11 | 2019-02-19 | 丛念滋 | Have effects that transport spleen dampness elimination, promoting the circulation of qi and middle herbaceous plant drink and preparation method thereof |
| CN110353064A (en) * | 2019-07-30 | 2019-10-22 | 广州致诚尚品医药科技有限公司 | In a kind of generation, makes tea drink |
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| CN112618694A (en) * | 2021-01-29 | 2021-04-09 | 杨洋 | Formula of ginseng and fingered citron tablets |
| CN113197999A (en) * | 2021-06-10 | 2021-08-03 | 马立庆 | Medicine and food homologous dampness eliminating formula |
| CN113648386A (en) * | 2021-07-31 | 2021-11-16 | 云南中医药大学 | Medicinal and edible compound composition and application thereof |
| WO2023074459A1 (en) * | 2021-10-28 | 2023-05-04 | 住友化学株式会社 | Composition for preventing, improving or alleviating symptoms relating to phlegm and dampness |
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| CN114343037A (en) * | 2022-01-04 | 2022-04-15 | 吕文亮 | Health tea bag for preventing pneumonia and preparation method thereof |
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