CN110420297A - A kind of Chinese materia medica preparation for anti-trioxypurine - Google Patents
A kind of Chinese materia medica preparation for anti-trioxypurine Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8994—Coix (Job's tears)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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Abstract
The present invention relates to a kind of preparations for anti-trioxypurine, are made of the raw material of following parts by weight: 10-30 parts of semen coicis, 3-10 parts of dried orange peel, 5-10 parts of peach kernel, 10-16 parts of Poria cocos, 5-10 parts of wrinkled giant hyssop, 32-65 parts of corn stigma, 5-10 parts of cassia seed, 3-6 parts of the root of Dahurain angelica, 6-15 parts of Prunella vulgaris, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of rhizoma atractylodis, 10-15 parts of lophatherum gracile.Refined through modern science compatibility, main strengthening spleen, tonifying kidney, dampness removing let out it is turbid based on, spleen kidney is with controlling with original, and removing damp and turbid is to radically reform.The therapies such as qi-regulating, clearing damp, promoting blood circulation, stagnation resolvation are imposed according to the characteristics of disease, and acid discharge while eliminates internal a large amount of biologic garbage, improves metabolic function, keeps blood pure, because complication caused by blood is all effectively improved.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of Chinese materia medica preparation for anti-trioxypurine.
Background technique
By 2018, China's people with high uric acid alreadyd exceed 100,000,000, high every year also with the natural speed increase of 3-5%
Uricacidemia has become the second largest metabolic disease for being only second to hyperglycemia.The drug of anti-trioxypurine is mostly anti-inflammatory analgesic medicine at present,
Though can rapid pain relief, treat acute gout, these product Time of Administration are long, effect is unstable, side effect is big, such as
The damage that gastrointestinal tract can be caused different degrees of, causes hepatic and renal function abnormal etc. when serious, take for a long time, can cause bone marrow suppression,
Necrosis of liver cells and neurotoxicity etc..
In traditional Chinese medical science field, gout belongs to " numbness disease ", it is believed that gout is to influence kidney, kidney cannot be just because of liver, Dyssplenism
Normal catharsis aqueous body fluid makes body metabolism disorder, and wet, phlegm, becoming silted up produces, raw in turbid poison, so as to cause gout.Long-term high lithemia
Goat can be caused, Patients with Hyperuricemia not necessarily has goat, and gout patient must be caused by hyperuricemia.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of Chinese materia medica preparation for anti-trioxypurine.
The technical solution adopted by the present invention to solve the technical problems is: a kind of preparation for anti-trioxypurine, by following heavy
Measure number raw material composition: 10-30 parts of semen coicis, 3-10 parts of dried orange peel, 5-10 parts of peach kernel, 10-16 parts of Poria cocos, 5-10 parts of wrinkled giant hyssop,
32-65 parts of corn stigma, 5-10 parts of cassia seed, 3-6 parts of the root of Dahurain angelica, 6-15 parts of Prunella vulgaris, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of rhizoma atractylodis, henon bamboo
10-15 parts of leaf.
Specifically, a kind of preparation for anti-trioxypurine, is made of: semen coicis 20-30 the raw material of following parts by weight
Part, 5-10 parts of dried orange peel, 5-10 parts of peach kernel, 15 parts of Poria cocos, 5-10 parts of wrinkled giant hyssop, 50 parts of corn stigma, 5-10 parts of cassia seed, root of Dahurain angelica 3-6
Part, 10-15 parts of Prunella vulgaris, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of rhizoma atractylodis, 15 parts of lophatherum gracile.
Specifically, the preparation is dosage form described in any pharmacy, and the raw material is cleaned, is dried
Dry, crushing, subsequently into workshop, raw material is extracted, and is uniformly mixed, and tablet or other doses are made in qualified semi-finished product
Type, other dosage forms include liquor, paste, powder, any dosage form in pill.
Beneficial effects of the present invention: that the present invention overcomes current anti-trioxypurine product Time of Administration is long, effect is unstable, secondary work
With big deficiency, refined through modern science compatibility, main strengthening spleen, tonifying kidney, dampness removing let out it is turbid based on, spleen kidney is with controlling with original, benefit
Humidifying is turbid to radically reform.The therapies such as qi-regulating, clearing damp, promoting blood circulation, stagnation resolvation are imposed according to the characteristics of disease, and acid discharge while eliminates in vivo
A large amount of biologic garbage improves metabolic function, keeps blood pure, because complication caused by blood is all effectively improved,
Such as coronary heart disease, hyperlipidemia, hypertension, diabetes；Be independently operated, it is without side-effects, using simple, definite effect, no region, people
Kind selection differential, all ethnic groups can be taken, and being can be by detection method verification the verifying results at regular time and quantity, the anti-trioxypurine of pure plant
Product.
Specific embodiment
The present invention is described in further detail now.
Semen coicis: it is sweet in flavor, light, it is cool in nature.Returns spleen, stomach, lung channel.Advantageous water penetration is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, removing toxic substances
The effect of dissipating bind.For oedema, tinea pedis, difficult urination, splenasthenic diarrhea, arthritis with fixed pain caused by dampness muscular constricture, pulmonary abscess, acute appendicitis；Wart, cancerous swelling.
Dried orange peel: it is bitter, pungent, it is warm-natured.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea,
Coughing with a lot of sputum.
Peach kernel: bitter, sweet, flat.Return heart, liver, large intestine channel.Promoting blood circulation, relax bowel and defecation is relieving cough and asthma.For amenorrhea and algomenorrhea,
Lump in the abdomen lump in the abdomen lump in the abdomen, pulmonary abscess acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.
Poria cocos: it is sweet in flavor, light, it is mild-natured.Return heart, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen, calming heart.For edema and little urine, phlegm
Drink feel dizzy and heart palpitations, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Wrinkled giant hyssop: acrid flavour, it is warm-natured.Returns spleen, stomach, lung channel.Dampness elimination is amusing, ward off it is dirty and in, relieving summer-heat is delivered.For dampness taste,
Abdominal fullness and distention, damp-warm syndrome are from the beginning of diseases such as, vomiting, diarrhea, summer-heat and damp, fever with chilliness, fever with aversion to cold, chest distress.
Corn stigma: it is sweet in flavor, light, it is mild-natured.Return bladder, liver, gallbladder channel.There is inducing diuresis to remove edema；The effect of clear liver and gallbladder.Main oedema,
Dribbling urination, jaundice, cholecystitis, gall stone, hypertension, diabetes, alactation.
Cassia seed: it is sweet in flavor, bitter, it is cold in nature, it is micro- salty.Return liver, large intestine channel.It clears liver and improve vision, relax bowel and defecation.For the puckery pain of hot eyes,
The more tears of photophobia, headache and dizziness, mesh is secretly unknown, constipation.
The root of Dahurain angelica: acrid in flavour and warm in nature.Enter lung, spleen, stomach meridian.Wind-dispelling, eliminating dampness are reduced swelling, analgesic.Control headache, pain in the supra-orbital bone, dentalgia, nose
Deep pool, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, skin itchy, scabies.
Prunella vulgaris: it is pungent, bitter, it trembles with fear.Return liver, gallbladder channel.Clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.
Rhizoma Chuanxiong: bitter is acrid in flavour and warm in nature.Enter liver, gallbladder channel.Promote breath and open depression, it is wet to dispel wind-dryness, promoting blood circulation and stopping pain.It is dizzy to control air-cooled headache rotation,
Hypochondriac pain abdomen pain, arthritis muscle contraction, menostasis, difficult labour, postpartum stasis block pain, ulcer sores.For irregular menstruation, amenorrhea and algomenorrhea, lump in the abdomen abdomen
Bitterly, pricking pain in the chest, tumbling and swelling, headache, rheumatic arthralgia.
Rhizoma atractylodis: acrid flavour, hardship, it is warm-natured.Returns spleen, stomach, Liver Channel.It is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For damp retention in middle-jiao, gastral cavity
Distention and fullness in the abdomen, diarrhea, oedema, tinea pedis impotence is preesed, rheumatic arthralgia, anemofrigid cold, yctalopia, and eyes dusk is puckery.
Lophatherum gracile: lophatherum gracile is sweet in flavor, light, cold in nature.Return heart, lung, stomach, bladder meridian；Body, which gently seeps, to be let out, and has clearing heat and relieving fidgetness, benefit
Urinate treating stranguria effect.With clearing heat and relieving fidgetness, ten cure mainly pyreticosis and polydipsia, aphthae, swelling and aching of gum, children the effect of inducing diuresis for treating strangurtia
Crying with fear, cough with lung heat, stomach hot vomiting, hot urination stranguria with turbid discharge.
Embodiment 1
A kind of Chinese materia medica preparation for anti-trioxypurine takes semen coicis 20g, dried orange peel 5g, peach kernel 10g, Poria cocos 15g, wrinkled giant hyssop 5g, beautiful
Rice palpus 50g, cassia seed 5g, root of Dahurain angelica 5g, Prunella vulgaris 10g, Rhizoma Chuanxiong 5g, rhizoma atractylodis 5g, lophatherum gracile 15g, these raw materials are cleaned,
Drying crushes, and subsequently into workshop, raw material is extracted, and is uniformly mixed, and tablet, total raw material is made in qualified semi-finished product
150g is made 300, bottles, and 150 every bottle.
Instructions of taking: before invented food, arriving first regular hospital and carry out blood uric acid detection, and hyperuricemia person can take,
Three times a day, 5 tablets once, and 30 minutes after meal, warm water delivery service arrived hospital after 20 days edible again and detects blood uric acid, blood uric acid number
Value variation is obvious, can be down within normal value.
Embodiment 2
A kind of Chinese materia medica preparation for anti-trioxypurine takes semen coicis 25g, dried orange peel 6g, peach kernel 6g, Poria cocos 15g, wrinkled giant hyssop 5g, beautiful
Rice palpus 50g, cassia seed 5g, root of Dahurain angelica 5g, Prunella vulgaris 9g, Rhizoma Chuanxiong 4g, rhizoma atractylodis 5g, lophatherum gracile 15g, these raw materials are cleaned,
Drying crushes, and subsequently into workshop, raw material is extracted, and is uniformly mixed, and tablet, total raw material is made in qualified semi-finished product
150g is made 300, bottles, and 150 every bottle.
Instructions of taking: three times a day, 5 tablets once, and 30 minutes after meal, warm water delivery service was examined to hospital again after 20 days edible
Blood uric acid is surveyed, blood uric acid numerical value change is obvious, can be down within normal value.
Embodiment 3:
A kind of Chinese materia medica preparation for anti-trioxypurine takes semen coicis 28g, dried orange peel 6g, peach kernel 6g, Poria cocos 15g, wrinkled giant hyssop 6g, beautiful
Rice palpus 50g, cassia seed 5g, root of Dahurain angelica 5g, Prunella vulgaris 6g, Rhizoma Chuanxiong 3g, rhizoma atractylodis 5g, lophatherum gracile 15g, these raw materials are cleaned,
Drying crushes, and subsequently into workshop, raw material is extracted, and is uniformly mixed, and tablet, total raw material is made in qualified semi-finished product
150g is made 300, bottles, and 150 every bottle.
Instructions of taking: three times a day, 5 tablets once, and 30 minutes after meal, warm water delivery service.It is examined again to hospital after 20 days edible
Blood uric acid is surveyed, blood uric acid numerical value change is obvious, can be down within normal value.
Effect test:
Healthy rat is randomly divided into: Normal group, model control group, the combined tablet-preparation test group 1 of the present invention of embodiment 1,
The combined tablet-preparation test group 2 of the present invention of embodiment 2, the combined tablet-preparation test group 3 of the present invention of embodiment 3, every group of 10 rats, except normal
Outside control group feeding normal diet, other groups give high purine feed modeling daily, continuous 20 days, are administered the 20th day, take blood,
Each group of other serum uric acid is measured, then Normal group, model control group continue feeding normal diet, 1 feeding of test group
Combined tablet-preparation in the embodiment of the present invention 1, the combined tablet-preparation in the 2 feeding embodiment of the present invention 2 of test group, 3 feeding sheet of test group
Combined tablet-preparation in inventive embodiments 3, successive administration 20 days, test result was shown in Table 1, can be obtained by table 1, the group in the present invention
Closing tablet has apparent anti-trioxypurine to act on.
Table 1 is the content (μm ol/L) of serum uric acid during the test of each group
| Group | UA before modeling | After modeling 20d | Pharmaceutical quantities g/Kg | After 20d is administered | Anti-trioxypurine percentage |
| Blank control group | 49.30±1.35 | 44.78±2.60 | 0.0 | 50.06±0.78 | --- |
| Model control group | 45.72±0.71 | 125.66±0.96 | 0.0 | 118.70±3.1 | --- |
| Test group 1 | 55.32±1.54 | 116.34±1.50 | 0.05 | 65.78±3.2 | 43.45 |
| Test group 2 | 44.78±2.23 | 123.59±1.95 | 0.05 | 70.53±1.30 | 42.93 |
| Test group 3 | 47.88±1.43 | 130.65±2.35 | 0.05 | 63.78±2.21 | 51.18 |
The present invention is not limited to the embodiment, anyone should learn that the structure made under the inspiration of the present invention becomes
Change, the technical schemes that are same or similar to the present invention are fallen within the scope of protection of the present invention.
Technology not described in detail in the present invention, shape, construction portion are well-known technique.
Claims (3)
1. a kind of preparation for anti-trioxypurine, it is characterised in that: be made of the raw material of following parts by weight: 10-30 parts of semen coicis,
3-10 parts of dried orange peel, 5-10 parts of peach kernel, 10-16 parts of Poria cocos, 5-10 parts of wrinkled giant hyssop, 32-65 parts of corn stigma, 5-10 parts of cassia seed, the root of Dahurain angelica
3-6 parts, 6-15 parts of Prunella vulgaris, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of rhizoma atractylodis, 10-15 parts of lophatherum gracile.
2. a kind of preparation for anti-trioxypurine according to claim 1, it is characterised in that: described a kind of for anti-trioxypurine
Preparation is made of the raw material of following parts by weight: 20-30 parts of semen coicis, 5-10 parts of dried orange peel, 5-10 parts of peach kernel, 15 parts of Poria cocos, the leaves of pulse plants
5-10 parts fragrant, 50 parts of corn stigma, 5-10 parts of cassia seed, 3-6 parts of the root of Dahurain angelica, 10-15 parts of Prunella vulgaris, 3-6 parts of Rhizoma Chuanxiong, rhizoma atractylodis 5-10
Part, 15 parts of lophatherum gracile.
3. a kind of preparation for anti-trioxypurine according to claim 1, it is characterised in that: the preparation is any one
Described dosage form, the raw material is cleaned, dried, is crushed, subsequently into workshop, raw material is mentioned in kind pharmacy
It takes, is uniformly mixed, tablet or other dosage forms is made in qualified semi-finished product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772611A (en) * | 2019-12-13 | 2020-02-11 | 赵洪勇 | Traditional Chinese medicine composition for regulating gout |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772611A (en) * | 2019-12-13 | 2020-02-11 | 赵洪勇 | Traditional Chinese medicine composition for regulating gout |
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Application publication date: 20191108 |