CN105876435A - Anti-oxidizing composition soft capsule and preparation method thereof - Google Patents

Abstract

The invention relates to the field of food preparations and particularly relates to walnut oil, or a preparation method of a walnut oil soft capsule and applications thereof. The walnut oil soft capsule is mainly composed of the walnut oil, a grape seed extract, vitamin E, vitamin A, gelatin, glycerol, bee wax, titanium dioxide, water for injection, pigments and the like. The preparation method includes the steps of preparing a content material liquid, preparing a gum liquid, pelletizing the content material liquid and the gum liquid, shaping and drying the capsules, selecting and washing the capsules, and drying and packaging the capsules. The capsule has good stability, is convenient to take and easy to absorb, and is simple in preparation method.

Description

A kind of for antioxidant composition soft capsule and preparation method thereof

Technical field

The present invention relates to the prescription that antioxidation walnut oil is main component and the method making soft capsule.

Background technology

Human body is because of the continuous contact with the external world, including breathing the factors such as (oxidation reaction), outside contamination, lonizing radiation irradiation not Disconnected produces free radical in human body.Scientific investigations showed that, cancer, aging or Other diseases mostly with the generation of excessive free radicals Relevant.

Increasing research display antioxidation is pre-anti-aging important step, and antioxidation refers to the abbreviation of resisting oxidation free radical. Because free radical or oxidant decompose cell and tissue, affect metabolic function, and cause different health problems.If able to disappear Except too much oxyradical, it is possible to that prevent to cause due to many free radicals and aging-related disease all, as common cancer, Arteriosclerosis, diabetes, cataract, cardiovascular diseases, senile dementia, arthritis etc., these diseases are considered to and free radical Relevant.

Antioxidation is exactly any material that there is the oxidation reaction that just can effectively suppress free radical with low concentration, and its mechanism of action is permissible It is to directly act on free radical, or indirectly consumes the material easily generating free radical, prevent to react further.Human body While being inevitably generated free radical, also naturally producing the antioxidant resisting free radical, to offset free radical Oxidative attacks to human body cell.Research prove, the antioxidant system of human body be one can comparable with immune system, have Improving and the system of sophisticated functions, body antioxidative ability is the strongest, the most healthy, and life is the longest.

The antioxidant of human body has and self synthesizes, and also has by food supply.Enzyme and non-enzymatic antioxidant protection due to The peroxide injury that motion causes plays vital effect.Supplementary antioxidant is conducive to Exercise Mechanics to reduce free radical Produce or accelerate it and remove, with the side effect to free radical resisting, thus the most useful to common people and athletic health, Ke Nengyan Slow sports fatigue occurs and accelerates physical efficiency recovery, and older physical exertion person is more preferable than year the lighter takes antioxidant effect.

The adverse effect of radical pair protein is its most important aspect to harm, is first that free radical is directly to protein Oxidative demage and the crosslinking degeneration that causes, this is one of old and feeble major reason formed.The consequence master of destruction direct to protein Have: (1) can make pheron inactivation become the enzyme of another kind of catalysis wrong reaction；(2) occur that some has the albumen of heterogeneity Matter, thus cause autoimmune response；(3) that connective tissue albumen can be made to occur is extensively cross-linked for free radical so that it is manage, the property changed Matter changes, cause blood and tissue between exchange reduce so that it is in organ-tissue accelerate aging degenerate.These degeneration simultaneously The original function of connective tissue the most partially or completely loses.Second aspect of radical pair protein adverse effect is to core The oxidation of acid and crosslinking, make DNA rupture, suddenly change and change the stability of heat, thus had a strong impact on egg The normal transcription of white matter hereditary information, translation process, make protein expression amount reduce and even disappear, or produce mutein. When this impact is reflected in pheron and the key protein such as hormone, immunologic active material, its coverage is bigger, and consequence is the most more Seriously.And protein synthesis reduce be the performance such as senile hypomnesis, dysnoesia and amyotrophy major reason it One.The impact of radical pair protein relates to face very extensively in a word, and consequence is seriously complicated, is that free radical is important with what aging contacted Tie.

With the growth at age, in human body, Free Radical Level shows a rising trend, and free radical scavenging mechanism is but in degradation trend simultaneously, knot Fruit causes interior free yl to gather in a large number.So the damaging effect of radical pair body health is gradually serious, cause body multiple The obstacle of physiological function, promote multiple infirmities of age (as atherosclerosis, cardiovascular and cerebrovascular disease, cranial nerve cell degeneration, Diabetes and tumor etc.) generation, development, cause the aging of body, until dead.In whole aging course, free radical Causing substantial amounts of cell ageing, death, the most great mass of data shows that the aging of these cells, dead many belong to freely The apoptosis (apoptosis) that base causes.

Appropriate radical pair has certain effect in anti-local infection etc., but excessive free radicals is then for unsaturated fatty acid, albumen Matter molecule, nucleic acid molecules, extracellular soluble composition and cell membrane etc. have extremely harmful destructive effects.In body from It is engraved in time at the very start and produces free radical.But there is again effective Free-radical ring opening polymerization simultaneously, just maintaining interior free yl Ordinary water is put down.But, with advancing age, this balance can change.

Lot of experiments data is it has been proved that infection, inflammation and other cytokine such as interferon (IFN) etc. all can make in-vivo tumour Necrosin (TNF) level increases, and the TNF of excess makes the activation of substantial amounts of phagocyte strengthen phagocytosis, and this can make Phagocyte excess generation respiratory burst and discharge excessive free radicals, make tissue local and Plasma free radical level excess improve and right Body produces a large amount of free radicals and makes to have the mucopolysaccharide generation oxidative degradation of lubrication in lubricating fluid in articular cavity and lose lubrication Effect, this is one of the important mechanisms that rheumatic arthritis occurs.And for example excessive free radicals accumulation in blood can make cell tight Weight is impaired, has a strong impact on cytomorphosis ability and makes it hardening, and its surface is roughening in addition makes stickiness increase, so passing through capillary The formation micro-embolization that is blocked it is prone to during blood vessel.One of this important pathogenesis being probably some senile Cardial or cerebral vascular diseases.

The health food on domestic market with anti-oxidation function is increasingly welcome by consumers in general, current anti-oxidation function Though health food few, but a lot of product all obtains good economic benefit, has obtained being widely recognized as of market.

Semen Juglandis is a kind of nutritious health food having again special medical effect deeply looked at by consumers in general parent.As in Semen Juglandis The walnut oil of main nutrient composition, oleic acid, linoleic acid, α--the content of the unsaturated fatty acids such as linolenic acid more than 90%, its Central Asia Oleic acid is the fatty acid of needed by human, can not synthesize, it is necessary to obtain from food in human body；α--linolenic acid has and drops significantly Blood pressure, blood fat reducing, improve the effects such as cardiovascular and cerebrovascular disease.

The fat content of Semen Juglandis is up to 60%-70%.The walnut oil refined by Semen Juglandis has the most nourishing healthy of Semen Juglandis And pharmacological effect composition, containing various bioactivators.Containing abundant unsaturated fatty acid in walnut oil, linoleic acid and α- Linolenic acid content is respectively 70% and about 10%.Wherein ω-6 and ω-3 series polyunsaturated fatty acid ratio is 6-7: 1, meets FAO (Food and Agriculture Organization of the United Nation) (FAO) and the recommendation of World Health Organization (WHO) (WHO).ω-6: ω-3=5-10: 1, it is a kind of content of fatty acid The edible oil and fat the most relatively reasonable with ratio.Possibly together with the multivitamins such as vitamin E and mineral element in walnut oil, possibly together with The lot of trace functional components such as nervonic acid, gadoleic acid, EPA, DHA, Squalene, melatonin, flavone, carotene.Core Fructus Persicae oil through animal toxicity, mutagenesis, teratology testing have been demonstrated nontoxic, without carcinogenic components, be preferably eaten for a long time.Japan is core Fructus Persicae oil is as senior edible health oil, and in the international market, walnut oil is the most popular with consumers, wide market.

At present the functional scientific research report of walnut oil be mainly reflected in auxiliary adjustment of blood fat, cholesterol reducing, improve memory, The aspects such as antioxidation, increase bone density, enhancing immunity, resisting fatigue.At present from State Food and Drug Administration data base From the point of view of Query Result, cover " auxiliary improvement of memory " etc. with the health product that walnut oil is declared to approve for major ingredient functional, Such as: declared " good fortune is according to the board gastrodia-walnut fat capsule " of registration by Weilong Biological Industry Co., Ltd., Yunnan Prov., suitable population is Need to improve the middle-aged and elderly people (the strong word G20100075 of state's food, approved date is 2010-2-11) of memory.

From the point of view of present case, walnut oil can be applied for supplementary, also can apply for having anti-oxidation function, auxiliary fall blood Fat function, auxiliary function for lowering blood pressure, auxiliary improving memory function.It is anti-that the application of antioxidant can effectively resist free-radical oxidation Answer brought harm, so antioxidation is classified as one of main R&D direction by Health Products Enterprises, be also the most important merit in market One of energy property demand.Based on above-mentioned present situation, we are according to walnut oil self functional characteristic, in conjunction with domestic and international research report, invention A kind of walnut oil soft capsule with anti-oxidation function.

The generation of the old and feeble and various disease of human body is broken relevant with vivo oxidation with Antioxidation reaction dynamic equilibrium, various natural Antioxidant for maintain this balance play good health-care effect.The primary raw material of the present invention is walnut oil and Semen Vitis viniferae The compositions such as extract, have anti-oxidation function, and its concrete theoretical foundation is as follows:

1. walnut oil

Semen Juglandis, has another name called Semen Juglandis, oil-containing 650～700g/kg in core, and unsaturated fatty acid content is up to more than 800g/kg, its Central Asia Oleic acid accounts for 62.2%, and linolenic acid accounts for 13.4%.In addition, possibly together with various trace elements in walnut oil, such as Ca, P, K, Zn, Na, Fe, Cu, Mn and vitamin A, D, E etc..Research to walnut oil anti-oxidation function is the most much reported, for walnut oil is developed into Anti-oxidation functional food provides strong theoretical foundation.Give mouse stomach with various dose walnut oil continuously, detect little after 3 weeks Total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT) and gluathione in Hepar Mus, cerebral tissue The activity of peptide peroxidase (GSH-PX).Result shows, compared with matched group, 17mL/ (kg d) walnut oil can significantly (P ＜ 0.05) Improve T-AOC in Mouse Liver, cerebral tissue, the vigor of SOD, CAT, GSH-PX, show that this dosage walnut oil can improve enzyme Antioxidation, and when dosage reaches 33mL/ (kg d), effect is best.

Studies have reported that Jilin wild walnut oil is to aged animal rat model antioxidant ability of organism and hippocampal tissue beta-amyloyd The impact of peptide (A β) content, has inquired into wild walnut oil to the pass between body oxidability and hippocampal tissue A β changes of contents System.With ovariectomized female rats as aged rat model, give basic, normal, high (0.6,1.2,2.4g/kg) dosage Wild hickory oil Gavage, measures Hippocampus homogenate total number born (T-SOD), the level of malonaldehyde (MDA) with biochemical process；Elisa detects The change of A β content in Hippocampus homogenate.Result shows, compares with ovariectomized female rats, and walnut oil intervention group rat is with Semen Juglandis oil preparation Amount increases serum T-SOD activity and substantially increases；MDA content all significantly reduces, and hippocampal tissue A β content declines.Therefore draw Conclusion, hickory oil can reduce the A β level of ovariectomized female rats hippocampal cell, effect protected to hippocampal cell；Its mechanism of action After may intervening with walnut oil, the oxidation resistance raising of body is relevant.

Someone with peroxide value (POV) as index study temperature, the time is on the impact of walnut oil oxidation process and adds antioxygen The agent impact on walnut oil antioxygenic property.Result shows, there are highly significant temperature, time to the oxidizing process of walnut oil Impact.The antioxidant that vitamin E is stronger in being present in cell system, it is possible to as the Natural antioxidant conventional in food, Use a certain amount of VE to maintain walnut oil activity stabilized in our current research, be used for suppressing walnut oil because of peroxidating during preserving And the effect breathing out change produced.Also there are some researches show, VE has reduction liver plasma membrane lipid peroxidation injury effect, and walnut oil is multiple Closing VE reduce plasma cholesterol and raise the effect of HDL-C than walnut oil effect substantially, this also illustrates to have one between the two Fixed bio-cooperation.

Also studies have reported that the result of study to walnut oil acute toxicity and long term toxicity.Acute toxicity uses bliss method to measure core The LD of Fructus Persicae oil₅₀.Long term toxicity selects 6～8 weeks healthy Wistar rats 60, male and female half and half, is randomly divided into 3 groups: Semen Juglandis Oil low dose group, high dose group, respectively with 4.3g/kg and 13g/kg gavage.Once a day, matched group is with 1mL/kg physiology salt Water gavage, each group is all administered once a day, continuous 12 weeks.It is both needed to observe that animal general behavior is movable, food-intake every day, and Observed the weight of animals change every 2 weeks during administration.24h after last administration, will often organize the Animal Anesthesia of 3/4, moves from stock Arteries and veins is taken a blood sample, and takes urine from bladder, checks blood, routine urinalysis；Liver and kidney function；Gather the internal organs such as the heart, liver, spleen, lung, kidney, naked eyes Observe its pathological change, make pathological section and further look at.Result shows: the maximum of gastric infusion of walnut oil mice is resistance to By amount more than 40g/kg；The maximum tolerated dose that walnut oil mice once abdominal cavity injection is administered is more than 40g/kg.Compared with matched group, The walnut oil successive administration of two kinds of dosage 12 weeks, the body weight of animal, behavior, blood, routine urinalysis, Liver and kidney function are poor without significance Not (P ＞ 0.05)；The internal organs such as the heart, liver, spleen, lung, kidney are also without obvious pathological change.Therefore, we can be determined that walnut oil safety Nontoxic, reliable.

2. the antioxidation of adjuvant-Semen Vitis viniferae extract

Semen Vitis viniferae contains abundant polyphenols, is referred to as grape polyphenols.Wherein the main component of Semen Vitis viniferae extract is oligomeric former flower Blue or green element (OPC) and anthocyanin, account for more than the 95% of total polyphenols.The topmost function of grape seed polyphenols is exactly the antioxidation merit that it is the strongest Can, other function is as also many based on its antioxidant activity in prevention cardiovascular disease etc..It is mainly manifested in removing superoxide radical and hydroxyl The free radicals such as free radical, and the peroxidating of suppression lipid.Japanese scholars chemoluminescence method and cytochrome C reducing process measure OPC and VC of Semen Vitis viniferae extract, the VE Scavenging activity to free radical, the effect such as result OPC is much better than VC, VE.

Also someone have studied the antioxidation of Semen Vitis viniferae extract.40 male Kunming kind aged mouses are pressed blood MDA level Be randomly divided into matched group, Semen Vitis viniferae extract basic, normal, high dosage group, each group mice per os respectively gives 0.334,0.667, The Semen Vitis viniferae capsule 's content of 2.001g/kg body weight dose and edible oil, after 30 days, measure MDA content, SOD and 6SH-Px Vigor.Result shows to compare with matched group, and high dose group can significantly reduce MDA content in blood (P ＜ 0.05) and significantly improve blood Clear SOD vigor (P ＜ 0.05), GSH-Px in serum vigor is had no significant effect (P ＞ 0.05) by each dosage group.Therefore conclude that Grape pip procyanidin extract has antioxidation to aged mouse, and this result is that Semen Vitis viniferae is applied to that crowd is edible to be provided Good experimental basis.

In sum, the health-care effect of Semen Juglandis is well known by consumer, and the antioxidation of walnut oil has passed through multiple research Having arrived confirmation, the edible safety of walnut oil is the highest, and in the soft capsule of the present invention, the content of walnut oil, adjuvant Semen Vitis viniferae carry The content of the compositions such as the content and the VE that take thing meets the law of food safety, meets food additive operating specification, meets health care Food test and assessment technique specification, meet China's dietary nutrition of urban residents recommended amounts, there is good antioxidation.

In the face of increasingly serious food-safety problem, people are the strongest to the demand of " healthy ", and the most vigorous " health preserving tide " has caused whole society's concern to health and health preserving especially, and healthy living filled up by increasing health food Blank.People stride into the functional of diversification till now from the gift consumption that the past is single to the consumption demand of health food Consumption, its envelop of function covers the full field of health of people consumption, overall process, full stage, and health food is consumed by people Regard new fashion as.Along with improving constantly of the flourish of China's economy and living standards of the people, Health-care Foods Industry will have more Wide market and good development prospect.Data shows, in American-European countries's average consumption, the consumption in terms of health product account for always More than the 25% of expenditure, and China is 0.07% now, per capita health product consumption the chances are 31 yuan, be the 1/17 of the U.S., day This 1/12, this is just illustrating that the development potentiality of China's health product is huge.

National food industry " the 12 " development plan that the Ministry of Science and Technology issues is pointed out, the direction of China's food ingredient development It is nutrition, green, health, safe and reliable.By revenue growth, the raising of product permeability, aged tendency of population and consumer education The impact of the factors such as level, China's health food market starts recovery, and following will holding quickly increases.Have 20 the most in the world Well-known health product multinational corporations of many families, by purchasing, annexing, the form such as lease, sets up subsidiary factory in China.According to statistics, nearly five Over Nian, external health product sales volume in China market is often increasing with the speed of more than 12% every year.China's health products trade at present There is following several distinguishing feature:

1. concentration is compared in the place of production.China's health product are concentrated mainly on the ground such as Beijing, Jiangsu, Guangdong, Shanghai, Shandong, Hubei.At present In the health product that approved produces, 42.79% concentrates on the developed areas such as Beijing, Guangdong, Jiangsu, Shanghai.China keeps healthy The product place of production is not consistent with the distribution of the health product resource place of production, and this is relevant with economic development.It is therefore contemplated that following health product meeting Progressively spreading to the resource place of production, this allows for our main producing region Hunan Province at Semen Juglandis, with walnut oil for development of raw materials health care food Product will fully develop talents.

2. declare intimate many.Function distribution concentrates on immunomodulating, regulation blood fat, resisting fatigue 3.Survey data shows, In health food, the product of immunoloregulation function is most, accounts for the 37.3% of all over products, regulates the product second of blood fat, accounts for 13.6%, ranked third position is the product of resisting fatigue, accounts for the 10.8% of whole nation product, and this three series products accounts for whole health food city altogether The 61.7% of field, its income from sales accounts for the 41.4% of total sales volume.Unreasonable products structure, low-level repetition, function is concentrated Cause competition excessively fierce, be difficult to receive good economic benefit.The development of anticipated Science in Future in China market health product, product function To progressively disperse, product structure tends to be reasonable.We are positioned at anti-oxidation function by the walnut oil soft capsule of invention, have good Novelty and market prospect.

3. same materials overlapping development is many.Concentrate on spirulina, melatonin, fish oil, Ganoderma, shark cartilage, Cordyceps, chitin, Semen Ginkgo etc..Investigation shows, the product slates of raw material is: spirulina 67 kinds, melatonin 57 kinds, 52 kinds of fish oil, Ganoderma 20 Kind, shark cartilage 20 kinds, Cordyceps 19 kinds, chitin 19 kinds, Semen Ginkgo 19 kinds.At present, declare batch with walnut oil for major ingredient Accurate health product have 12 kinds, including " auxiliary improvement of memory ", " regulating blood lipoid ", " slow down aging ", " immune regulation ", " change Kind memory ", " improving sleep ", " nutrition enhancer " etc. functional.We " resist having with walnut oil for development of raw materials of invention Oxidative function " health product, have no product in the market.

Following health food market has following some consumption hot spots: before 1) subhealth state health food is considered to have good development Scape；2) health promoting product relevant to healthy sleep is the most also accomplished something；3) Chinese medicine class health food is expected to become market On the consumption growth point；4) arise at the historic moment and have a high potential in green health care food market.Every physical function of old people is in raw Reason catagen, obesity, hypertension, coronary heart disease, diabetes etc. are the chronic diseases that old people is common, and China's senile chronic sufferer Person is the mainstream populations of edible health food.As it was previously stated, " antioxidation " this key issue is point of penetration, exploitation is old in being suitable for The health product of year people, are to have complied with the market demand, have the biggest market potential.

The development prospect of National Health Foods industry is bright.Jin Anmingbang Survey Research Center is it is expected that enter in the market demand, technology Under the promotion of step and management update, " 12 " period average growth rate per annum of National Health Foods industry is up to 10%, 2010 years Whole nation sales volume reaches 105,800,000,000 yuan, within 2013, is about 150,000,000,000 yuan.

Along with the economic and development of society, health problem has become as the focus that the 21 century mankind pay close attention to.Society with fast rhythm lives, Various sign stimulus, makes the sympathetic nervous system of people be chronically at excited state, cause autonomic nervous system, hormonal system, Immune system dysfunction, internal redox reaction is on high level for a long time, thus has caused a series of health and asked Topic.The most especially with middle-aged and elderly people, the big person of physical demands amount, to suffer from patient in the majority.According to estimates, China in 2015 more than 60 years old Aging population are up to 2.16 hundred million, account for the 16.7% of total population, have a net increase of aging population more than 800 ten thousand every year；It addition, substantially The number that power consumes motion number, be in sub-health state is also being continuously increased.It was therefore concluded that, along with in China The quantity stating crowd increases, and the health food of market antagonism oxidation category will have relatively large demand.

The raw material of the present invention is walnut oil, and containing abundant unsaturated fatty acid, significant composition is that linoleic acid plus linolenic acid has Good antioxidation, therefore it is defined as the significant composition of the present invention, adjuvant is Semen Vitis viniferae extract, containing abundant polyphenol Class material, has good antioxidation, and supplementary material consumption is with reference to " health food inspection and assessment technique specification ", " health care Food registration supplementary material technology requires guide compilation " related request.

The raw material of the present invention is walnut oil, is liquid condition, if be directly administered orally, mouthfeel abnormal smells from the patient is difficult to be esthetically acceptable to the consumers, because of This preferably makes oral soft capsule class preparation.Soft capsule production Technology is ripe, is easily mastered, beneficially industrialized production.With Time soft capsule preparation, the bioavailability of functional factor is high, carries with easy to use, it is easy to feature, the institute such as be esthetically acceptable to the consumers It is made into soft capsule with us.

Summary of the invention

With wild walnut oil as main active, it is aided with the formula of Semen Vitis viniferae extract one high-efficiency antioxidant of composition, does plastic Capsule preparation, for requiring supplementation with the crowd of excessive free radicals in antioxidant, purged body, particularly mid-aged population, muscle power disappears Consume the Susceptible population such as big person, body constitution is more weak, the aging of hypoimmunity, physical function, patient groups provide have no side effect, high Effect, oxidation-resisting health-care food easy to use.The technical scheme that the present invention provides is: a kind of with walnut oil, Semen Vitis viniferae extraction Thing is that main prescription makes soft capsule.Wherein, walnut oil is the cold rolling extraction of wild walnut.

The first object of the present invention is to provide the application in epidemiology prevents of a kind of antioxidative prescription capsule.

Another object of the present invention is intended to overcome the defect of existing product, it is provided that a kind of antioxidant content walnut oil content is high, joins Close other such as Semen Vitis viniferae extract, vitamin E and vitamin A, its antioxidation is strong, and functional factor bioavailability is high, Have no side effect, carry antioxidant functional food-soft capsule preparation easy to use, and preparation method.Prescription is as follows:

Detailed description of the invention

The present invention is to be realized by following measures for a kind of antioxidant composition capsule.

Prescription:

Preparation technology is as follows:

This product is the soft capsule made for raw material with walnut oil, product select traditional pulverizing, sieve, weigh, feed liquid preparation, Glue preparation, pelleting, shape, be dried, select ball, wash ball, be dried again, the processing step such as packaging, be the flexible glue of a kind of maturation Capsule preparation technology.

1. take meet the qualified walnut oil of inspection, Semen Vitis viniferae extract, natural Vitamin E, vitamin A, Cera Flava, gelatin, glycerol, Purified water, titanium dioxide, pigment；

The most each supplementary material removes outer package, and inner packing enters clean area by buffer window；

3. pulverize, sieve: Semen Vitis viniferae extract is pulverized, crosses 100 mesh sieves, obtain fine powder, standby；

4. weigh: weigh walnut oil, Semen Vitis viniferae extract fine powder, natural Vitamin E, vitamin A, Cera Flava, bright by formula proportion Glue, glycerol, purified water, titanium dioxide, pigment；

5. prepared by content feed liquid: by walnut oil and Cera Flava, is jointly heated to 80 DEG C, is cooled to 30 DEG C, obtains oily after Cera Flava is melted Wax liquid；By oil wax liquid, Semen Vitis viniferae extract fine powder, natural Vitamin E, vitamin A stirring mixing, colloid mill grinds 2 Secondary make mix homogeneously, be slowly stirred degassing in 1～2 hour, obtain content feed liquid；

6. prepared by glue: when being heated to 60 DEG C, glycerol, purified water, titanium dioxide, pigment are added gelatin, continues to be heated to 70 DEG C, Heating 2～3h, stirs, changes glue, evacuation, filter (100 mesh sieve), stand, be incubated (60 DEG C), obtain glue；

7. pelleting: content feed liquid and the glue prepared are placed in pelleting in encapsulating machine, obtains soft capsule, 0.6g/ grain, temperature 18～ 26 DEG C, relative humidity 45～50%；

8. sizing: temperature 18～26 DEG C, relative humidity 30%～40%, time 2～4h；

9. it is dried: temperature 25～30 DEG C, relative humidity 30%～40%, time 18～24h；

10. select ball: reject substandard product；

11. wash ball: wash ball with 95% ethanol, wash away soft capsule surface and oil contaminant；

12. are dried: temperature 25～30 DEG C, relative humidity 35%～55%, time 1～2h；

13. inner packings: inner packaging material meets the standard of YBB00122002 oral stable medicinal polythene bottle with high density, 200/ Bottle；

14. outer package: housing material meets the standard of GB/T 6543 single and double corrugated boxes for transport packages；

15. inspection inspections: carried out product inspection by Quality Inspector；

16. warehouse-ins.

Claims (9)

1. an antioxidant composition soft capsule, it is characterized in that walnut oil is equipped with Semen Vitis viniferae extract, natural Vitamin E and vitamin A oil and Cera Flava makes soft capsule, wherein, in mass ratio: walnut oil: Semen Vitis viniferae: natural Vitamin E: vitamin A oil: Cera Flava=8: 1: 0.4: 0.005: 3.

Antioxidant composition capsule the most according to claim 1, it is characterised in that described walnut oil is Wild hickory cold rolling extraction gained.

Antioxidant composition capsule the most according to claim 1, it is characterised in that described Semen Vitis viniferae extract is containing anthocyanidin 60%.

Antioxidant composition capsule the most according to claim 1, it is characterised in that described vitamin E is natural Vitamin E (1000IU/100g=67.1%).

Antioxidant composition capsule the most according to claim 1, it is characterised in that described vitamin A oil is 1,000,000 IU/g (=30%).

Antioxidant composition capsule the most according to claim 1, it is characterised in that described Cera Flava is pharmaceutical grade.

7. the preparation of the antioxidant composition capsule described in claim 1-6, it is characterised in that use walnut oil and Cera Flava, be jointly heated to 80 DEG C, is cooled to 30 DEG C after Cera Flava is melted, obtains oily wax liquid；By oil wax liquid, Semen Vitis viniferae extract fine powder, natural Vitamin E, vitamin A stirring mixing, colloid mill grinds and makes mix homogeneously 2 times, is slowly stirred degassing in 1～2 hour, makes soft capsule after obtaining content feed liquid.

8. preparing according to the antioxidant composition capsule described in claim 1-7, its method is as follows:

A. take and meet the qualified walnut oil of inspection, Semen Vitis viniferae extract, natural Vitamin E, vitamin A, Cera Flava, gelatin, glycerol, purified water, titanium dioxide, pigment；

The most each supplementary material removes outer package, and inner packing enters clean area by buffer window；

C. pulverize, sieve: Semen Vitis viniferae extract is pulverized, crosses 100 mesh sieves, obtain fine powder, standby

D. weigh: weigh walnut oil, Semen Vitis viniferae extract fine powder, natural Vitamin E, vitamin A, Cera Flava, gelatin, glycerol, purified water, titanium dioxide, pigment by formula proportion；

E. prepared by content feed liquid: by walnut oil and Cera Flava, is jointly heated to 80 DEG C, is cooled to 30 DEG C, obtains oily wax liquid after Cera Flava is melted；By oil wax liquid, Semen Vitis viniferae extract fine powder, natural Vitamin E, vitamin A stirring mixing, colloid mill grinds and makes mix homogeneously 2 times, is slowly stirred degassing in 1～2 hour, obtains content feed liquid；

F. prepared by glue: when being heated to 60 DEG C, glycerol, purified water, titanium dioxide, pigment are added gelatin, continues to be heated to 70 DEG C, heat 2～3h, stirring, change glue, evacuation, filter (100 mesh sieve), stand, be incubated (60 DEG C), obtain glue；

G. pelleting: content feed liquid and the glue prepared are placed in pelleting in encapsulating machine, obtain soft capsule, 0.6g/ grain, temperature 18～26 DEG C, relative humidity 45～50%；

H. sizing: temperature 18～26 DEG C, relative humidity 30%～40%, time 2～4h；

I. it is dried: temperature 25～30 DEG C, relative humidity 30%～40%, the time 18～24h；

J. ball is selected: reject substandard product；

K. wash ball: wash ball with 95% ethanol, wash away soft capsule surface and oil contaminant；

L. it is dried: temperature 25～30 DEG C, relative humidity 35%～55%, the time 1～2h；

M. inner packing: inner packaging material meets the standard of YBB00122002 oral stable medicinal polythene bottle with high density, 200/bottle.

9. the antioxidant composition capsule described in claim 1-7, it is characterised in that described walnut oil purposes in preparation and antioxidant food compositions thereof.