CN111035012A - Antioxidant nutrition combination capsule and preparation method thereof - Google Patents

Antioxidant nutrition combination capsule and preparation method thereof Download PDF

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Publication number
CN111035012A
CN111035012A CN201911296257.5A CN201911296257A CN111035012A CN 111035012 A CN111035012 A CN 111035012A CN 201911296257 A CN201911296257 A CN 201911296257A CN 111035012 A CN111035012 A CN 111035012A
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vitamin
capsule
antioxidant
coenzyme
combination
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徐子卓
李晓
王卓凡
姜辉
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Qingdao Saier Biomedical Technology Co Ltd
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Qingdao Saier Biomedical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses an antioxidant nutrition combination capsule for health care, health promotion, life prolonging and a preparation method thereof, belonging to the technical field of health products, wherein β nicotinamide mononucleotide, coenzyme Q10, vitamin E, vitamin C, lipoic acid and other antioxidants are combined, β nicotinamide mononucleotide has the effects of regulating metabolism and prolonging life, mutually enhancing antioxidant and anti-aging effects, is a healthy young state of tissue cells of the whole body and enables life to be longer, is designed aiming at the defects of Chinese dietary characteristics, prevents energy and substance metabolism disorder caused by the deficiency of certain nutrient substances, combines vitamin B6, vitamin B12 and folic acid combination, can promote methionine metabolism by mutual cooperation, realizes the pivot of energy metabolism and substance metabolism of a human body, has the effects of effectively preventing arteriosclerosis, increases coenzyme Q10, has the effects of resisting oxidation, aging and the like, can play a role of protecting heart and important organs of the body, and can maintain the healthy state of functions of the human body.

Description

Antioxidant nutrition combination capsule and preparation method thereof
Technical Field
The invention relates to the technical field of health products, in particular to an antioxidant nutrition combination capsule and a preparation method thereof.
Background
In normal life, the maintenance of life requires complex biochemical reactions in the body to generate energy metabolism and substance metabolism to maintain the normal operation of the functions of various organs of the human body, wherein various substances play an important role in the complex biochemical reactions of the human body, and if the substances are not available, the human body cannot survive, and the substances are considered as important nutrient substances of the human body, including various vitamins, other biochemical substances and the like.
During energy and substance metabolism in the human body, the tricarboxylic acid cycle is the hub of energy metabolism, is performed in mitochondria of cells of the whole body, generates more energy through the tricarboxylic acid cycle, and maintains various physiological and biochemical normal operations of the human body so as to maintain normal functional operation of the human body. However, in the process of generating energy, many kinds of oxidation substances are generated at the same time, and most of the oxidation substances are electrons generated in metabolism, and form oxidation free radicals in tissues, so that the oxidation damage of tissue cells is caused, and the degeneration and the aging of human cell tissues are caused. There is a need for an antioxidant to protect the body from systemic tissue damage caused by oxidative free radicals generated in energy metabolism of the human body at any time, prevent the body from premature aging and aging caused by oxidative damage, and thus prolong the life of the human body.
Most of the antioxidant free radicals on the market are independent antioxidant components, and the components play a certain role in resisting the antioxidant free radicals, so that the health state of an organism is maintained; however, the antioxidant in the market contains single components and has limited antioxidation, cannot better meet the requirement of whole body cell tissue antioxidation, cannot make up for the damage caused by oxidative free radicals generated by various tissue cells of the whole body, and cannot better eliminate the health hidden trouble generated in human body energy metabolism.
With the continuous improvement of the living and health requirements of people, the design of a nutrient substance is more comprehensive, the more perfect antioxidant combination is considered, simultaneously, the nutrient substance which is damaged in the energy and substance metabolism can be supplemented, the aging is delayed, the organism tissue is protected to keep a young state, and the antioxidant composition is the necessary requirement of the antioxidant preparation on the market at present. With the increasing awareness of health and life extension, the demand for such antioxidant combination preparations is increasing.
Disclosure of Invention
The invention provides an antioxidant nutrition combination capsule and a preparation method thereof, which contain more nutrient substances needed in human body energy metabolism, ensure normal energy and substance metabolism of the human body, have obvious antioxidant and anti-aging functions, maintain the health state of human body functions and prolong the service life.
The specific technical scheme provided by the invention is as follows:
on one hand, the antioxidant nutrition combination capsule provided by the invention contains 150-900 mg of β -nicotinamide mononucleotide, 10-50 mg of coenzyme Q10, 50-500 mg of vitamin E, 100-1000 mg of vitamin C, 50-300 mg of lipoic acid, 0.4-5 mg of vitamin B6, 10-100 ug of vitamin B12 and 20-200 ug of folic acid.
Optionally, the vitamin B6, the vitamin B12 and the folic acid cooperate with each other to promote methionine circulation.
Optionally, the vitamin E is a fat soluble vitamin, the hydrolysate of the vitamin E is tocopherol, the vitamin C is a polyol, and the vitamin B6 includes pyridoxine, pyridoxal, and pyridoxamine.
Optionally, each of the antioxidant nutritional combination capsules further comprises gelatin, glycerin, water and caramel pigment.
Optionally, each of the antioxidant nutritional combination capsules contains β -nicotinamide mononucleotide (400 mg), coenzyme Q10 (30 mg), vitamin E (300 mg), vitamin C (600 mg), lipoic acid (240 mg), vitamin B6 (4.6 mg), vitamin B12 (85 ug), and folic acid (136 ug).
Optionally, said β -nicotinamide mononucleotide, said coenzyme Q10, said vitamin E, said vitamin C, and said lipoic acid cooperate and act synergistically to form an antioxidant combination.
Optionally, the vitamin E, the vitamin C, and the lipoic acid cooperate with the coenzyme Q10 to achieve a combined antioxidant effect.
In another aspect, the present invention also provides a method for preparing the antioxidant nutritional composition capsule, which includes:
adding distilled water into a gelatin melting tank, soaking gelatin in water to swell, heating to 60 deg.C after gelatin is dissolved, adding glycerol, stirring and mixing to melt gelatin and glycerol into uniform gelatin solution;
keeping the temperature of the glue solution in a glue barrel at 60 ℃ and standing for 5h, then vacuumizing to remove air bubbles and filtering the glue solution, keeping the temperature of the glue solution at 55-60 ℃, and connecting the glue barrel with an automatic rotary capsule machine;
weighing the soybean oil and the beeswax according to the prescription amount, heating to 70 ℃, cooling to room temperature after the beeswax is completely melted, then adding the coenzyme Q10, the vitamin E and the lipoic acid according to the prescription amount, stirring, after the components are uniformly dissolved, sequentially adding the β -nicotinamide mononucleotide, the vitamin C, the vitamin B6, the vitamin B12 and the folic acid according to the prescription amount, grinding for 20min through a colloid mill after primary stirring, and vacuumizing to eliminate bubbles after grinding to obtain the content of the soft capsule;
starting the automatic rotary capsule machine, setting the soft capsule loading amount to be 0.48 g/capsule after each index of the automatic rotary capsule machine is regulated normally, pouring the prepared soft capsule content into a hopper of the soft capsule machine, enabling the liquid medicine to flow into an injector through a discharge pipe, enabling the content to be injected into adhesive tapes on two sides through a spraying body, forming the soft capsule through rolling die pressing, setting for 2 hours under the conditions of 25 ℃ and 25-30% of relative humidity, and then drying for 16 hours at 30 ℃ to obtain the antioxidant nutrition combination capsule.
Optionally, the average particle weight of the antioxidant nutrition combination capsule is 0.472g, the average volume of the content is 0.485mL, and each antioxidant nutrition combination capsule contains 150-900 mg of β -nicotinamide mononucleotide, 10-50 mg of coenzyme Q10, 50-500 mg of vitamin E, 100-1000 mg of vitamin C, 50-300 mg of lipoic acid, 0.4-5 mg of vitamin B6, 10-100 ug of vitamin B12 and 20-200 ug of folic acid.
The invention has the following beneficial effects:
the embodiment of the invention provides an antioxidant nutrition combination capsule, which combines β nicotinamide mononucleotide, coenzyme Q10, vitamin E, vitamin C, lipoic acid and other antioxidants, synergistically enhances antioxidant and anti-aging effects, protects tissue cells of the whole body, keeps healthy and young tissue cells of the whole body, enables life to be longer, is designed aiming at the defects of Chinese dietary characteristics, prevents energy and substance metabolism disorder caused by the lack of certain nutrients, combines vitamin B6, vitamin B12 and folic acid combination, can promote methionine metabolism by matching the three components, realizes the pivot of energy metabolism and substance metabolism of a human body, has the effects of effectively preventing arteriosclerosis, enables various human body metabolism to be carried out healthily, increases the effects of antioxidation, anti-aging and the like of coenzyme Q10, can play a role of protecting heart and important organs of the body, and can maintain the health state of functions of the human body.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below, and it should be apparent that the described embodiments are only a part of the embodiments of the present invention, not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention provides an antioxidant nutrition combination capsule which contains 150-900 mg of β -nicotinamide mononucleotide, 10-50 mg of coenzyme Q10, 50-500 mg of vitamin E, 100-1000 mg of vitamin C, 50-300 mg of lipoic acid, 0.4-5 mg of vitamin B6, 10-100 ug of vitamin B12 and 20-200 ug of folic acid, wherein the vitamin B6, the vitamin B12 and the folic acid are matched with each other to promote methionine circulation, the vitamin E is a fat-soluble vitamin, a hydrolysate of the vitamin E is tocopherol, the vitamin C is a polyhydroxy compound, and the vitamin B6 comprises pyridoxine, pyridoxal and pyridoxamine.
Preferably, each anti-oxidation nutrition combination capsule contains β -nicotinamide mononucleotide of 400mg, coenzyme Q10 of 30mg, vitamin E of 300mg, vitamin C of 600mg, lipoic acid of 240mg, vitamin B6 of 4.6mg, vitamin B12 of 85ug and folic acid of 136ug, and the anti-oxidation effect of the anti-oxidation nutrition combination capsule in the proportion is the best.
The β -nicotinamide mononucleotide, the coenzyme Q10, the vitamin E, the vitamin C and the lipoic acid in the antioxidant nutrition combination capsule provided by the embodiment of the invention are matched with each other and have synergistic action to form an antioxidant combination, and the vitamin E, the vitamin C and the lipoic acid cooperate with the coenzyme Q10 to realize combined antioxidant effect.
The β Nicotinamide Mononucleotide (NMN) adopted in the antioxidant nutrition combination capsule plays an important role in the generation of human cell energy, participates in the synthesis of intracellular NAD + (also called Nicotinamide adenine dinucleotide, important coenzyme for cell energy conversion), and is a precursor substance of NAD +.
The coenzyme Q10 adopted in the antioxidant nutrition combination capsule provided by the embodiment of the invention not only can provide power for the heart, but also has excellent functions of resisting oxidation and removing free radicals, can prevent lipid peroxidation of blood vessel walls and atherosclerosis, and has no toxic or side effect. Vitamin e (vitamin e) is a fat-soluble vitamin, and the hydrolysate thereof is tocopherol, which is one of the most important antioxidants. Vitamin E can promote reproductive function, protect T lymphocyte, protect erythrocyte, resist free radical oxidation, inhibit platelet aggregation, thereby reducing risk of myocardial infarction and cerebral infarction; also has good curative effect on burn, cold injury, capillary vessel hemorrhage, climacteric syndrome, beauty treatment and the like; can inhibit lipid peroxide reaction in eye lens, dilate peripheral blood vessel, and improve blood circulation; can effectively resist free radicals, inhibit lipid peroxide generation, and remove chloasma; inhibiting tyrosinase activity, thereby reducing melanin production; the esterified vitamin E can also eliminate excessive oxygen free radicals caused by external factors such as ultraviolet rays and air pollution, and has the effects of delaying photoaging, preventing sunburn, inhibiting generation of sunburn erythema and the like.
The vitamin C adopted in the antioxidant nutrition combination capsule provided by the embodiment of the invention is similar to glucose in structure and is a polyhydroxy compound. Vitamin C has strong reducibility and is easily oxidized into dehydrovitamin C, but the reaction is reversible, and ascorbic acid and dehydroascorbic acid have the same physiological functions. Vitamin C is necessary for antibody and collagen formation, tissue repair (including certain redox actions), metabolism of phenylalanine, tyrosine and folic acid, utilization of iron and carbohydrate, synthesis of fat and protein, maintenance of immune function, hydroxylation of 5-hydroxytryptamine, blood vessel integrity maintenance, non-heme iron absorption promotion and the like, and simultaneously the vitamin C also has the effects of oxidation resistance, free radical resistance and tyrosinase inhibition, so that the effects of whitening and spot lightening are achieved. The antioxidation of vitamin C can be understood as a 'protection effect', and the stronger antioxidation of vitamin C can be utilized in modern medical treatment to inhibit the oxidative damage of free radicals to human bodies, thereby preventing the invasion of tumors and cancers.
The lipoic acid adopted in the antioxidant nutrition combination capsule provided by the embodiment of the invention is coenzyme existing in mitochondria, is similar to vitamin, can eliminate free radicals which cause accelerated aging and disease, and has the characteristics of fat solubility and water solubility, and the lipoic acid plays a role in two key oxidative decarboxylation reactions, namely, in a pyruvate dehydrogenase complex and a α -ketoglutarate dehydrogenase complex, the lipoic acid catalyzes the generation and transfer of acyl groups, α -lipoic acid contains a disulfide five-membered ring structure, has high electron density and obvious electrophilicity and the capability of reacting with free radicals, so the lipoic acid has oxidation resistance, has extremely high health care function and medical value (such as the effects of resisting fatty liver and reducing plasma cholesterol), in addition, the sulfhydryl group of the lipoic acid can be easily subjected to redox reaction, the sulfhydryl enzyme can be protected from heavy metal ion poisoning, and the lipoic acid can be easily reduced into dihydrolipoic acid after entering a human body, both can promote the regeneration of vitamin C and vitamin E and play an antioxidant role, and the coenzyme Q10 can increase intracellular glutathione and can also increase metal ions and can play an antioxidant role.
The vitamin B6 adopted in the antioxidant nutrition combination capsule provided by the embodiment of the invention comprises pyridoxine, pyridoxal and pyridoxamine, is a water-soluble vitamin, is easy to damage by light or alkali and cannot resist high temperature. Participating in protein synthesis and catabolism and participating in all amino acid metabolism; participating in protein synthesis and catabolism, participating in all amino acid metabolism, especially methionine metabolism; important substances for maintaining body functions. The adopted vitamin B12 can participate in the synthesis of methionine, thymine and the like, promotes the development and maturation of erythrocytes, has the function of activating amino acid, promotes the biosynthesis of nucleic acid, can promote the anabolism of protein, and ensures that fatty acid, carbohydrate and protein are properly applied by the body; is an indispensable vitamin for the functional perfection of the nervous system, participates in the formation of lipoprotein in nervous tissues and maintains the metabolism and the function of the myelin sheath of the nerve.
β -nicotinamide mononucleotide, coenzyme Q10, vitamin E, vitamin C and lipoic acid cooperate and act synergistically to form an antioxidant combination with a specific health-care effect, wherein β -Nicotinamide Mononucleotide (NMN), which plays an important role in the cellular energy production of the human body, is involved in the synthesis of intracellular NAD + (nicotinamide adenine dinucleotide, an important coenzyme for cellular energy conversion), NAD + is also called coenzyme i, which is known as nicotinamide adenine dinucleotide, also known as nicotinoside diphosphate, there are aspects that are involved in thousands of reactions in each cell, involved in the metabolism of the human body, which is a key coenzyme, but with the increase of age, the NAD + level in the human body is gradually decreasing, at age 40, the NAD + level in the human body is only 25% of the childhood period, after age 80, it decreases to 6.25% of the infant, the decrease of NAD + results in a decrease in mitochondrial activity, mitochondria, cells and even the whole body, and gradually enters the cycle of the childhood, which is a major factor for the supplementation of NAD + and NAD molecules, which is the most responsible for the rapid increase of NAD + production by oral administration, the oral uptake of NAD + is a precursor, which is the most responsible for the rapid rate-limiting factor for the aging of NAD + production of NAD.
NMN is an intermediate in the salvage synthesis pathway of Nicotinamide adenine dinucleotide (NAD +) in mammals. NMN (Nicotinamide mononucleotide) is the product of the Nicotinamide phosphoribosyltransferase (napt) reaction, one of the key precursors of NAD +. In mammals, NMN is produced by Nicotinamide (namide, Nam) catalyzed by Nampt, followed by NMN producing NAD + catalyzed by Nicotinamide mononucleotide adenyl transferase (Nmnat). Extracellular NMN requires dephosphorylation to Nicotinamide Riboside (NR) before entering the interior of hepatocytes, after which NR is phosphorylated by Nicotinamide riboside kinase 1 (NRK 1) to form NMN, which is then combined with ATP to form NAD +. NMN exerts its physiological functions in the human body by being converted to NAD +, such as activating NAD + substrate-dependent enzyme Sirt1 (histone deacetylase, also known as sirtuin), regulating cell survival and death, maintaining redox status, and the like. The regular NMN intake can effectively increase the content of NAD + in vivo, thereby helping human to repair DNA damage, prevent degenerative diseases and delay aging. This is also the core mechanism by which NMN reverses aging and prolongs life.
The tricarboxylic acid cycle (TCA cycle) is a ubiquitous metabolic pathway in aerobic organisms. Prokaryotes are distributed in the cytoplasm, and eukaryotes are distributed in mitochondria. Since several of the major intermediary metabolites in this cycle are organic acids containing three carboxyl groups, such as citric acid, the so-called tricarboxylic acid cycle, also known as the citric acid cycle or the TCA cycle. The tricarboxylic acid cycle is the final metabolic pathway of three major nutrients (carbohydrate, lipid and amino acid) and is also the hub of carbohydrate, lipid and amino acid metabolic connection.
During the tricarboxylic acid cycle, as metabolism proceeds, a large amount of electrons are produced, which are an oxidant, i.e., oxygen radicals, which are normal metabolites of cells, and in general, the production and elimination of free radicals are in a dynamic equilibrium state, and once the equilibrium is broken, the accumulation of free radicals in vivo may cause oxidative stress, leading to peroxidation of DNA, lipids and proteins, causing mitochondrial dysfunction and apoptosis. Oxidative stress and mitochondrial dysfunction are causal, forming a malignant cycle, and causing the degeneration and aging of human metabolic tissues.
Coenzyme Q10 is the only naturally occurring, renewable, lipid-soluble antioxidant in the human body. Coenzyme Q10 exists in 2 forms in the body, including oxidized form and reduced form, 2 forms can be mutually converted in the body, but only reduced coenzyme Q10 can play an anti-oxidation role in the body. The antioxidation of coenzyme Q10 is mainly embodied in scavenging free radicals, synergistic action with other antioxidant substances, resisting apoptosis and stabilizing cell membrane. Coenzyme Q10 can scavenge free radicals in vivo, reduce oxidative stress, and improve mitochondrial dysfunction by converting redox structure.
The mechanism of action of coenzyme Q10 for inhibiting apoptosis may include ① for protecting mitochondrial DNA, coenzyme Q10 for scavenging oxygen free radicals, reducing oxidative stress, preventing mitochondrial DNA mutation caused by peroxidative damage, maintaining mitochondrial respiratory chain integrity, and reducing apoptosis, ② for increasing mitochondrial ATP production efficiency, promoting cell metabolism and growth, and slowing apoptosis, ③ for inhibiting mitochondrial depolarization, coenzyme Q10 for inhibiting mitochondrial permeability transition channel opening, and mitochondrial depolarization, thereby inhibiting cytochrome C release and procaspase-9 (procaspase-9) activation, inhibiting mitochondrial dependent apoptosis pathway activation, and ④ for inhibiting active oxygen (ROS) -related apoptosis pathway in renal proximal tubular cells, coenzyme Q2 for significantly inhibiting nicotine-induced ROS production and apoptosis, and coenzyme Q10 3 for phosphorylating coenzyme Q66 shc, activating antioxidant response element (antioxidant response element 829) and aromatase, and superoxide dismutase (Mn493), thereby promoting aging of heart, and aging, and preventing aging of organism.
The vitamin E, the vitamin C and the lipoic acid in the antioxidant nutritional combination capsule of the embodiment of the invention cooperate with the coenzyme Q10 to realize the combined antioxidant effect. Particularly, the lipoic acid is easy to be reduced into dihydrolipoic acid after entering a human body, and the lipoic acid and the coenzyme Q10 are matched with each other to promote the regeneration of vitamin C and vitamin E and play an antioxidation role. The antioxidant nutrition combination capsule provided by the embodiment of the invention can also increase glutathione and coenzyme Q10 in cells and can chelate certain metal ions. The antioxidant combination can better optimize oxygen free radicals in energy and substance metabolism, resist degeneration and aging of organisms, keep the organisms in a healthy state and prolong the life.
The vitamin B6, the vitamin B12 and the folic acid in the antioxidant nutrition combination capsule have the significance of participating in methionine circulation, the homocysteine (Hcy) is an intermediate product of methionine metabolism, the anabolic pathway and related enzyme systems (methionine synthetase and cystathionine β synthetase) of the Hcy are deficient, and the folic acid, the B12 and the B6 are deficient to cause hyperhomocysteinemia.
A large number of experimental studies show that the methionine circulation is involved in the metabolic mechanism of the organism as follows:
(1) methionine cycling and transmethylation: methionine (methionine) containing S-methyl must be combined with ATP to generate S-adenosylmethionine (SAM, also called active methionine) before transferring methyl, under the action of methyltransferase, methyl can be transferred to methyl group receiver by SAM to make it be methylated to generate methylated product (choline), at the same time, SAM can be converted into S-adenosyl-homocysteine after removing methyl, and can be further removed to generate homocysteine. Homocysteine can receive methyl provided by N5-methyltetrahydrofolic acid to produce methionine (methionine), so that a circulation process called methionine (methionine) circulation is formed. The enzyme catalyzing the conversion of N5-methyltetrahydrofolate to methyl methionine is called methionine synthase (also called methionine methyltransferase, N5-methyltetrahydrofolate methyltransferase), the coenzyme of which is VB12 (vitamin B12), which is involved in the transfer of methyl. A variety of important physiologically active substances containing methyl groups can be produced by various transmethylations, such as: choline can further produce lecithin (promoting myelination) or form acetylcholine (involved in neurotransmitter recovery).
(2) One carbon unit cycle: in addition, in the presence of coenzyme VB12 (vitamin B12), N5-methyltetrahydrofolic acid is demethylated by methionine transferase to form tetrahydrofolic acid, which receives a carbon unit provided by amino acid to form N10-formyltetrahydrofolic acid and then further forms N5, N10-methyltetrahydrofolic acid, which forms N5-methyltetrahydrofolic acid by N5, N10-methylenetetrahydrofolic acid reductase to form another cycle to the "one-carbon unit cycle". Among them, N5, N10-methylenetetrahydrofolate reductase is a key coenzyme for thymidylate synthase, which catalyzes the conversion of deoxyguanosine monophosphate (d-UMP) to deoxythymidine monophosphate (d-TMP) in the reactions necessary for pyrimidine biosynthesis, thereby promoting DNA synthesis and repair.
(3) When VB12 (vitamin B12) is deficient, the methyl of N5-methyltetrahydrofolic acid cannot be transferred, which is not only unfavorable for the generation of methionine, but also influences the transmethylation effect and influences the smooth generation of various physiologically active methylated organisms; meanwhile, the generation of tetrahydrofolic acid is also influenced, so that the free tetrahydrofolic acid in tissues is reduced, the tetrahydrofolic acid cannot be reused for transporting a carbon unit, the synthesis of pyrimidine is influenced, the synthesis of DNA nucleic acid is caused, and the repair is influenced. In addition, when VB12 (vitamin B12) is deficient, homocysteine is influenced to be methylated to generate methionine, so that homocysteine is accumulated, and the hyperhomocysteinemia is considered to have important pathological significance at present and is an independent risk factor of diseases such as atherosclerosis, stroke, dementia and the like.
(4) In certain tissues, such as the liver or kidney, through the process of retro-sulfuration, homocysteine is converted to cystathionine by cystathionine β synthase to further produce cysteine, γ -Glu-cysteine, and finally glutathione.
(5) When folic acid is deficient, one-carbon unit circulation is affected and nucleic acid and protein biosynthesis is affected, leading to disease.
The embodiment of the invention provides an antioxidant nutrition combination capsule, which combines β nicotinamide mononucleotide, coenzyme Q10, vitamin E, vitamin C, lipoic acid and other antioxidants, synergistically enhances antioxidant and anti-aging effects, protects tissue cells of the whole body, keeps healthy and young tissue cells of the whole body, enables life to be longer, is designed aiming at the defects of Chinese dietary characteristics, prevents energy and substance metabolism disorder caused by the lack of certain nutrients, combines vitamin B6, vitamin B12 and folic acid combination, can promote methionine metabolism by matching the three components, realizes the pivot of energy metabolism and substance metabolism of a human body, has the effects of effectively preventing arteriosclerosis, enables various human body metabolism to be carried out healthily, increases the effects of antioxidation, anti-aging and the like of coenzyme Q10, can play a role of protecting heart and important organs of the body, and can maintain the health state of functions of the human body.
In another aspect, the present invention also provides a method for preparing the antioxidant nutritional composition capsule, which includes:
adding distilled water into a gelatin melting tank, soaking gelatin in water to swell, heating to 60 deg.C after gelatin is dissolved, adding glycerol, stirring and mixing to melt gelatin and glycerol into uniform gelatin solution;
keeping the temperature of the glue solution in a glue barrel at 60 ℃ and standing for 5h, then vacuumizing to remove air bubbles and filtering the glue solution, keeping the temperature of the glue solution at 55-60 ℃, and connecting the glue barrel with an automatic rotary capsule machine;
weighing the soybean oil and the beeswax according to the prescription amount, heating to 70 ℃, cooling to room temperature after the beeswax is completely melted, then adding the coenzyme Q10, the vitamin E and the lipoic acid according to the prescription amount, stirring, after the components are uniformly dissolved, sequentially adding the β -nicotinamide mononucleotide, the vitamin C, the vitamin B6, the vitamin B12 and the folic acid according to the prescription amount, grinding for 20min through a colloid mill after primary stirring, and vacuumizing to eliminate bubbles after grinding to obtain the content of the soft capsule;
starting the automatic rotary capsule machine, setting the soft capsule loading amount to be 0.48 g/capsule after each index of the automatic rotary capsule machine is regulated normally, pouring the prepared soft capsule content into a hopper of the soft capsule machine, enabling the liquid medicine to flow into an injector through a discharge pipe, enabling the content to be injected into adhesive tapes on two sides through a spraying body, forming the soft capsule through rolling die pressing, setting for 2 hours under the conditions of 25 ℃ and 25-30% of relative humidity, and then drying for 16 hours at 30 ℃ to obtain the antioxidant nutrition combination capsule.
The antioxidant nutrition combination capsule provided by the embodiment of the invention selects soybean oil as a substrate; the beeswax can play a role in preventing the medicine from settling, so that the medicine is not easy to precipitate when the product is pressed into pills or stored, and the beeswax can be selected as a suspending agent because the formula of the antioxidant nutritional combination capsule contains both oil-soluble nutritional ingredients and water-soluble nutritional ingredients; the capsule wall material of the antioxidant nutrition combination capsule is composed of gelatin and water, a certain amount of glycerin is added to be used as a plasticizer of the capsule shell of the soft capsule, and a certain amount of caramel color is added to the capsule wall material for avoiding light due to the fact that vitamin B6 in the formula has light instability.
The average particle weight of the antioxidant nutrition combination capsule is 0.472g, the average volume of contents is 0.485mL, and each antioxidant nutrition combination capsule contains 150-900 mg of β -nicotinamide mononucleotide, 10-50 mg of coenzyme Q10, 50-500 mg of vitamin E, 100-1000 mg of vitamin C, 50-300 mg of lipoic acid, 0.4-5 mg of vitamin B6, 10-100 ug of vitamin B12 and 20-200 ug of folic acid.
The antioxidant nutrition combination capsule of the embodiment of the invention is designed aiming at the defects of Chinese dietary characteristics, prevents energy and substance metabolism disturbance caused by the deficiency of certain nutrients, combines vitamin B6, vitamin B12 and folic acid combination, promotes methionine metabolism, effectively prevents arteriosclerosis and enables various metabolisms of human bodies to be carried out healthily, increases various vitamins, promotes the energy metabolism and substance metabolism of human bodies more comprehensively.
It will be apparent to those skilled in the art that various modifications and variations can be made in the embodiments of the present invention without departing from the spirit or scope of the embodiments of the invention. Thus, if such modifications and variations of the embodiments of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to encompass such modifications and variations.

Claims (9)

1. An antioxidant nutrition combination capsule for health care, rehabilitation and longevity is characterized in that each antioxidant nutrition combination capsule contains 150-900 mg of β -nicotinamide mononucleotide, 10-50 mg of coenzyme Q10, 50-500 mg of vitamin E, 100-1000 mg of vitamin C, 50-300 mg of lipoic acid, 0.4-5 mg of vitamin B6, 10-100 ug of vitamin B12 and 20-200 ug of folic acid.
2. The antioxidant nutritional combination capsule of claim 1, wherein the vitamin B6, vitamin B12, and folic acid cooperate to promote methionine circulation.
3. The antioxidant nutritional combination capsule of claim 1 or 2, wherein the vitamin E is a fat soluble vitamin, the hydrolysis product of vitamin E is tocopherol, the vitamin C is a polyol, and the vitamin B6 comprises pyridoxine, pyridoxal and pyridoxamine.
4. The antioxidant nutritional combination capsule of claim 1 further comprising gelatin, glycerin, water, and caramel color per capsule.
5. The antioxidant nutritional combination capsule of any one of claims 1-4, wherein each of the antioxidant nutritional combination capsules comprises β -nicotinamide mononucleotide 400mg, coenzyme Q10 30mg, vitamin E300 mg, vitamin C600 mg, lipoic acid 240mg, vitamin B6 4.6mg, vitamin B12 85ug, and folic acid 136 ug.
6. The antioxidant nutritional combination capsule of claim 5, wherein the β -nicotinamide mononucleotide, the coenzyme Q10, the vitamin E, the vitamin C, and the lipoic acid cooperate and cooperate to form an antioxidant combination.
7. The antioxidant nutritional combination capsule of claim 6, wherein the vitamin E, the vitamin C, and the lipoic acid cooperate with the coenzyme Q10 to achieve a combined antioxidant effect.
8. A method for preparing the antioxidant nutrition combination capsule for health care, help longevity according to any one of claims 1 to 7, which comprises:
adding distilled water into a gelatin melting tank, soaking gelatin in water to swell, heating to 60 deg.C after gelatin is dissolved, adding glycerol, stirring and mixing to melt gelatin and glycerol into uniform gelatin solution;
keeping the temperature of the glue solution in a glue barrel at 60 ℃ and standing for 5h, then vacuumizing to remove air bubbles and filtering the glue solution, keeping the temperature of the glue solution at 55-60 ℃, and connecting the glue barrel with an automatic rotary capsule machine;
weighing the soybean oil and the beeswax according to the prescription amount, heating to 70 ℃, cooling to room temperature after the beeswax is completely melted, then adding the coenzyme Q10, the vitamin E and the lipoic acid according to the prescription amount, stirring, after the components are uniformly dissolved, sequentially adding the β -nicotinamide mononucleotide, the vitamin C, the vitamin B6, the vitamin B12 and the folic acid according to the prescription amount, grinding for 20min through a colloid mill after primary stirring, and vacuumizing to eliminate bubbles after grinding to obtain the content of the soft capsule;
starting the automatic capsule rotating machine, setting the soft capsule loading amount to be 0.48 g/capsule after each index of the automatic capsule rotating machine is regulated to be normal, pouring the prepared soft capsule content into a hopper of the soft capsule machine, enabling the liquid medicine to flow into an injector through a discharge pipe, enabling the content to be injected into adhesive tapes on two sides through a spraying body, forming the soft capsule through rolling die pressing, setting for 2 hours under the conditions of 25 ℃ and 25-30% of relative humidity, and then drying for 16 hours at 30 ℃ to obtain the antioxidant nutrition combination capsule for health care, help and longevity.
9. The method for preparing the antioxidant nutrition combination capsule for health care, life support and longevity according to claim 8, wherein the average particle weight of the antioxidant nutrition combination capsule is 0.472g, the average volume of the content is 0.485mL, each antioxidant nutrition combination capsule contains 150-900 mg of β -nicotinamide mononucleotide, 10-50 mg of coenzyme Q10, 50-500 mg of vitamin E, 100-1000 mg of vitamin C, 50-300 mg of lipoic acid, 0.4-5 mg of vitamin B6, 10-100 ug of vitamin B12 and 20-200 ug of folic acid.
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CN111529693A (en) * 2020-05-06 2020-08-14 林�吉 Health-care medicine containing polypeptide gel for activating body cell function and its preparing process
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