CN109464418A - A kind of vitamin C-vitamin E soft capsule and preparation method thereof - Google Patents
A kind of vitamin C-vitamin E soft capsule and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61P37/04—Immunostimulants
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Abstract
The present invention relates to soft capsule technical fields, more particularly to a kind of vitamin C-vitamin E soft capsule and preparation method thereof, soft capsule includes content and capsule skin, and the content includes the raw material of following parts by weight: 40-60 parts of L-AA, 20-40 parts of d- alpha-tocopherol, oily 350-450 parts and 10-20 parts of suspension aid of phase；The capsule skin includes the raw material of following parts by weight: 250-350 parts of gelatin, 100-140 parts of plasticizer, 2-3 parts of opacifier and 300-350 parts of water.Vitamin C-vitamin E soft capsule of the invention can effectively replenishing vitamins C and vitamin E, can be improved the immunity of the human body with oxidation and removing free radicals, safely and effectively, can be taken for a long time, and the shelf-life, at 24 months or more, product stability is strong.
Description
Technical field
The present invention relates to soft capsule technical fields, and in particular to a kind of vitamin C-vitamin E soft capsule and its preparation side
Method.
Background technique
Vitamin E (VitaminE) is a kind of liposoluble vitamin, and it is most important antioxygen that hydrolysate, which is tocopherol,
One of agent is dissolved in the organic solvents such as fat and ethyl alcohol, not soluble in water, is stablized to heat, acid, unstable to alkali, sensitive to oxygen,
It is insensitive to heat, but Vitamin E activity is substantially reduced when frying.Tocopherol can promote sex hormone to secrete, and make man's sperm motility
Increase with quantity；Increase woman's female hormone concentration, improve fecundity, prevention of miscarriage, it may also be used for prevention and treatment male sterility
Disease, burn, frostbite, capillary hemorrhage, climacteric syndrome, beauty etc..Recently it has also been found that vitamin E can inhibit eyes
Crystalline intracorporal lipid peroxidation reaction makes peripheral vasodilation, improves blood circulation, pre- Anti-myopic eye occurrence and development.
Vitamin C is antioxidant important in vivo, and is the required confactor for participating in certain hydroxylation reactions in vivo.It
Energy human activin immune system is supported to generate more Collagen materials, and the latter can enhance connective tissue, prevent influenza virus etc.
Diffusion in vivo.
Prior art most products are all independent replenishing vitamins C or vitamin E, and part compound formulation is in the shelf-life
It is shorter.
Summary of the invention
In order to overcome shortcoming and defect existing in the prior art, the purpose of the present invention is to provide a kind of vitamin C dimensions
Raw element E soft capsule and preparation method thereof, which can give human body replenishing vitamins C and vitamin E simultaneously, and the shelf-life is up to 24
A month.
The purpose of the invention is achieved by the following technical solution:
A kind of vitamin C-vitamin E soft capsule, including content and capsule skin, the content include following parts by weight
Raw material: 40-60 parts of L-AA, 20-40 parts of d- alpha-tocopherol, oily 350-450 parts and 10-20 parts of suspension aid of phase；Institute
State the raw material that capsule skin includes following parts by weight: 250-350 parts of gelatin, 100-140 parts of plasticizer, 2-3 parts of opacifier and water
300-350 parts.
L-AA, i.e. vitamin C can enhance the stress ability of immunocyte, and it is various can to prevent and treat flu etc.
Acute and chronic communicable disease or other diseases improve the metabolism of fat and lipoid especially cholesterol, prevent heart disease, subtract
The danger of low coronary heart disease, but vitamin C is easily oxidized, and vitamin E is a kind of powerful antioxidant, and radicals scavenging can be enhanced
Ability avoids ascorbic oxidation, and improves immunity；The present invention makes water by the cooperation of oil phase and suspension aid simultaneously
The vitamin C of dissolubility and fat-soluble vitamin E are stable in the presence of in capsule simultaneously, have preferable stability, long shelf-life
Up to 24 months.
Wherein, the oil is mutually at least one of soybean oil, walnut oil, sunflower oil and linolenic oil.Oily phase conduct
The stability of content can be improved in solvent, it is preferable that the oil is mutually by soybean oil, walnut oil and sunflower oil by weight 1:
The ratio of 1-3:1 forms, and soybean oil microelement rich in, cost is relatively low, and inoxidizability is strong；Walnut oil is rich in vitamin
A and vitamin E, have the benefits of brain tonic and intelligence development；Sunflower oil tocopherol content is abundant, and 95% the above are biologically active
Alpha-tocopherol.The present invention compounds the oily phase chemical property selected and stablizes, full of nutrition, and shelf-life and the health care of capsule can be improved
Performance.
Wherein, the suspension aid is at least one of beeswax, aluminum monostearate and ethyl cellulose.Preferably, institute
Stating suspension aid is beeswax, improves product stability.
Wherein, the plasticizer is at least one of glycerol and polyethylene glycol.Plasticizer can increase the toughness of soft capsule
And machinability, it is preferable that the plasticizer is made of glycerol and polyethylene glycol by weight the ratio of 1-3:1, easy to form,
Soft capsule batch quality is stablized, and capsule skin is fine and close, and surface is smooth, and color is thick and solid, the influence of light aging is effectively reduced, greatly
It extends the shelf life.
Wherein, the opacifier is at least one of titanium dioxide, calcium carbonate and zinc oxide.Preferably, the shading
Agent is micron-sized titanium dioxide, i.e., conventional titanium dioxide, whiteness is high, and light-proofness is strong, and with certain shielding ultraviolet rays
Effect.
When opacifier reaches Nano grade, such as nano-titanium dioxide, light absorpting ability enhancing, the shielding action of ultraviolet light
Also it can enhance, and have from antibacterial functions, the example that nano-titanium dioxide is added in capsule at present is more and more.But
Nano-titanium dioxide can not be decomposed by human body, and the nano particle entered in blood is virose to cell tool, but
The dosage of nano material is very little in capsule at present, can almost ignore its influence to human body, not yet cause people's
Pay attention to.But as health food, it is more much higher than drug to take frequency, if take frequency it is excessively high if, inevitably to sensitive body
The human body of matter will cause side reaction.
For this purpose, capsule skin further includes the composite particles of 4-10 parts by weight in the present invention, the composite particles are by microcrystalline cellulose
With nano-titanium dioxide by weight 2-4:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nanometer
Titanium dioxide carries out ultrasonic disperse, filtration drying by weight the ratio of 2-4:1 in water, can be prepared by.
Nano-titanium dioxide, which is added, in the present invention can preferably improve the stability of capsule skin, and in order to solve nano-silica
The metabolic problems for changing titanium, in advance disperse nano-titanium dioxide on the surface of microcrystalline cellulose, microcrystalline cellulose water absorption and swelling is received
Human body can be easily discharged in rice titanium dioxide therewith；And microcrystalline cellulose can also be improved the disintegrating property of capsule, and human body is internal
Tolerant absorption efficiency is higher；Furthermore microcrystalline cellulose also has certain light-proofness, and synergic nano titanium dioxide improves ultraviolet
Shielding action.
Preferably, the partial size of the nano-titanium dioxide is 80-100nm, and the particle diameter distribution D50 of the microcrystalline cellulose is
40-60 μm, nano-titanium dioxide can preferably be scattered in the surface of microcrystalline cellulose.
Wherein, the capsule skin further includes 0.04-0.08 parts by weight of lemon Huang and 1-1.4 parts by weight burnt sugar coloring.Pass through addition
Specific pigment enhances light-proofness, and stability further gets a promotion.
The preparation method of vitamin C-vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) preparation of vitamin C-vitamin E soft capsule: content and capsule liquid are pressed into soft capsule molding machine soft
Capsule to get arrive the vitamin C-vitamin E soft capsule.
Wherein, the temperature of mixed sols is 70-80 DEG C in the step (2), time 50-70min.
Wherein, the viscosity of the capsule liquid is 18000-30000mpas.
The beneficial effects of the present invention are: L-AA, i.e. vitamin C can enhance the stress ability of immunocyte, can
Various acute and chronic communicable diseases or the other diseases such as flu are prevented and treated, fat and lipoid especially cholesterol are improved
Metabolism prevents heart disease, lowers the danger of coronary heart disease, but vitamin C is easily oxidized, and vitamin E is a kind of strong anti-oxidation
Free radical scavenging ability can be enhanced in agent, avoids ascorbic oxidation, and improve immunity；The present invention passes through oily phase simultaneously
With the cooperation of suspension aid, makes water-soluble vitamin C and fat-soluble vitamin E while being stable in the presence of in capsule, have
Preferable stability, long shelf-life was up to 24 months.
Specific embodiment
For the ease of the understanding of those skilled in the art, below with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying refers to not is limitation of the invention.
Embodiment 1
A kind of vitamin C-vitamin E soft capsule, including content and capsule skin, the content include following parts by weight
Raw material: 15 parts of Se-enriched yeast, 30 parts of d- alpha-tocopherol, oily 440 parts and 15 parts of suspension aid of phase；The capsule skin includes following weight
Measure the raw material of number: 300 parts of gelatin, 120 parts of plasticizer, 2.4 parts of opacifier and 330 parts of water.
Wherein, the oil is mutually soybean oil.
Wherein, the suspension aid is beeswax.
Wherein, the plasticizer is glycerol.
Wherein, the opacifier is micron-sized titanium dioxide.
Wherein, the capsule skin further includes 0.06 parts by weight of lemon Huang and 1.2 parts by weight burnt sugar colorings.
The preparation method of vitamin C-vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) preparation of vitamin C-vitamin E soft capsule: content and capsule liquid are pressed into soft capsule molding machine soft
Capsule to get arrive the vitamin C-vitamin E soft capsule.
Wherein, the temperature of mixed sols is 75 DEG C in the step (2), time 60min.
Wherein, the viscosity of the capsule liquid is 24000mpas.
Embodiment 2
A kind of vitamin C-vitamin E soft capsule, including content and capsule skin, the content include following parts by weight
Raw material: 10 parts of Se-enriched yeast, 20 parts of d- alpha-tocopherol, oily 400 parts and 10 parts of suspension aid of phase；The capsule skin includes following weight
Measure the raw material of number: 250 parts of gelatin, 100 parts of plasticizer, 2 parts of opacifier and 300 parts of water.
Wherein, ratio of the oil mutually by soybean oil, walnut oil and sunflower oil by weight 1:1:1 forms.
Wherein, the suspension aid is aluminum monostearate.
Wherein, the plasticizer is made of glycerol and polyethylene glycol by weight the ratio of 1:1.
Wherein, the opacifier is micron-sized calcium carbonate.
Wherein, the capsule skin further includes 0.04 parts by weight of lemon Huang and 1 parts by weight burnt sugar coloring.
The preparation method of vitamin C-vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) preparation of vitamin C-vitamin E soft capsule: content and capsule liquid are pressed into soft capsule molding machine soft
Capsule to get arrive the vitamin C-vitamin E soft capsule.
Wherein, the temperature of mixed sols is 70 DEG C in the step (2), time 50min.
Wherein, the viscosity of the capsule liquid is 18000mpas.
Embodiment 3
A kind of vitamin C-vitamin E soft capsule, including content and capsule skin, the content include following parts by weight
Raw material: 20 parts of Se-enriched yeast, 40 parts of d- alpha-tocopherol, oily 500 parts and 20 parts of suspension aid of phase；The capsule skin includes following weight
Measure the raw material of number: 350 parts of gelatin, 140 parts of plasticizer, 3 parts of opacifier and 350 parts of water.
Wherein, ratio of the oil mutually by soybean oil, walnut oil and sunflower oil by weight 1:3:1 forms.
Wherein, the suspension aid is ethyl cellulose.
Wherein, the plasticizer is made of glycerol and polyethylene glycol by weight the ratio of 3:1.
Wherein, the opacifier is micron-sized zinc oxide.
Wherein, the capsule skin further includes 0.08 parts by weight of lemon Huang and 1.4 parts by weight burnt sugar colorings.
The preparation method of vitamin C-vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) preparation of vitamin C-vitamin E soft capsule: content and capsule liquid are pressed into soft capsule molding machine soft
Capsule to get arrive the vitamin C-vitamin E soft capsule.
Wherein, the temperature of mixed sols is 80 DEG C in the step (2), time 70min.
Wherein, the viscosity of the capsule liquid is 30000mpas.
Embodiment 4
The present embodiment the difference from embodiment 1 is that:
Capsule skin further includes the composite particles of 7 parts by weight in the present embodiment, and the composite particles are by microcrystalline cellulose and nanometer
Titanium dioxide by weight 3:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nano-titanium dioxide
Ultrasonic disperse, filtration drying are carried out in water by weight the ratio of 3:1, can be prepared by.
Preferably, the partial size of the nano-titanium dioxide is 90nm, and the particle diameter distribution D50 of the microcrystalline cellulose is 50 μ
m。
Embodiment 5
The present embodiment the difference from embodiment 1 is that:
Capsule skin further includes the composite particles of 4 parts by weight in the present embodiment, and the composite particles are by microcrystalline cellulose and nanometer
Titanium dioxide by weight 2:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nano-titanium dioxide
Ultrasonic disperse, filtration drying are carried out in water by weight the ratio of 2:1, can be prepared by.
Preferably, the partial size of the nano-titanium dioxide is 80nm, and the particle diameter distribution D50 of the microcrystalline cellulose is 40 μ
m。
Embodiment 6
The present embodiment the difference from embodiment 1 is that:
Capsule skin further includes the composite particles of 10 parts by weight in the present embodiment, and the composite particles are by microcrystalline cellulose and nanometer
Titanium dioxide by weight 4:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nano-titanium dioxide
Ultrasonic disperse, filtration drying are carried out in water by weight the ratio of 4:1, can be prepared by.
Preferably, the partial size of the nano-titanium dioxide is 100nm, and the particle diameter distribution D50 of the microcrystalline cellulose is 60 μ
m。
Comparative example 1
This comparative example capsule skin further includes the microcrystalline cellulose of 7 parts by weight, and the particle diameter distribution D50 of the microcrystalline cellulose is 50
μm
To embodiment 1-6 carry out organoleptic requirements, physical and chemical index, microbiological indicator, functional component index test, meet as
Lower index request:
1.1 organoleptic requirements
1.2 physical and chemical index
| Project | Index | Detection method |
| Acid value, mg/g | ≤3.0 | GB 5009.229 |
| Peroxide value, g/100g | ≤0.25 | GB 5009.227 |
| Disintegration time limited, min | ≤60 | The Pharmacopoeia of the People's Republic of China |
| Ash content, % | ≤5.0 | GB 5009.4 |
| Aflatoxin B1, μ g/kg | ≤10 | GB 5009.22 |
| Lead, mg/kg | ≤2.0 | GB 5009.12 |
| Total arsenic, mg/kg | ≤1.0 | GB 5009.11 |
| Total mercury, mg/kg | ≤0.3 | GB 5009.17 |
1.3 microbiological indicator
| Project | Index | Detection method |
| Total plate count, CFU/g | ≤30000 | GB 4789.2 |
| Escherichia coli, MPN/100g | ≤0.92 | GB 4789.3 |
| Mould and yeast, CFU/g | ≤50 | GB 4789.15 |
| Staphylococcus aureus | ≤0/25g | GB 4789.10 |
| Salmonella | ≤0/25g | GB 4789.4 |
1.4 functional component indexs
By These parameters test it is found that soft capsule of the invention is safe and effective, it is suitble to require supplementation with vitamin C and vitamin
The adult of E can be improved the immunity of the human body with oxidation and removing free radicals.
In order to verify the effect of composite particles of the present invention, the present invention is by the soft capsule of embodiment 1, embodiment 4 and comparative example 1
Room temperature ((25 DEG C ± 2 DEG C of temperature, RH60 ± 10%) place 12,24 months, test disintegration time limited, obtain following table:
From the comparative analysis of initial burst time limit, it is known that microcrystalline cellulose can promote the disintegration of capsule, but not have in itself
There is the soft capsule of microcrystalline cellulose that there is preferable disintegration, therefore the castering action of microcrystalline cellulose and non-significant.
From lateral time comparative analysis, the soft capsule disintegration time limited of embodiment 1 always is highest, though and comparative example 1
Right disintegration time limited is consistently lower than embodiment 1, it is contemplated that the initial burst time limit with regard to low reason, what microcrystalline cellulose primarily served
Effect is raising disintegration, but for delaying gelatin to have no obvious effect, and the present invention is mixed into nanometer in microcrystalline cellulose
After titanium dioxide, disintegration timeliness obviously decreases, it was demonstrated that nano-titanium dioxide plays the role of ultraviolet shielded well and certainly anti-
Bacterium effect has delayed gelatin aging, therefore is disintegrated timeliness and maintains lower level always.
Above-described embodiment is the preferable implementation of the present invention, and in addition to this, the present invention can be realized with other way,
Do not depart under the premise of present inventive concept it is any obviously replace it is within the scope of the present invention.
Claims (9)
1. a kind of vitamin C-vitamin E soft capsule, including content and capsule skin, it is characterised in that: the content includes as follows
The raw material of parts by weight: 40-60 parts of L-AA, 20-40 parts of d- alpha-tocopherol, 350-450 parts of oily phase and suspension aid 10-
20 parts；The capsule skin includes the raw material of following parts by weight: 250-350 parts of gelatin, 100-140 parts of plasticizer, 2-3 parts of opacifier
With 300-350 parts of water.
2. a kind of vitamin C-vitamin E soft capsule according to claim 1, it is characterised in that: the oil is mutually soybean
At least one of oil, walnut oil, sunflower oil and linolenic oil.
3. a kind of vitamin C-vitamin E soft capsule according to claim 1, it is characterised in that: the suspension aid is bee
At least one of wax, aluminum monostearate and ethyl cellulose.
4. a kind of vitamin C-vitamin E soft capsule according to claim 1, it is characterised in that: the plasticizer is glycerol
At least one of with polyethylene glycol.
5. a kind of vitamin C-vitamin E soft capsule according to claim 1, it is characterised in that: the opacifier is dioxy
Change at least one of titanium, calcium carbonate and zinc oxide.
6. a kind of vitamin C-vitamin E soft capsule according to claim 1, it is characterised in that: the capsule skin further includes
0.04-0.08 parts by weight of lemon Huang and 1-1.4 parts by weight burnt sugar coloring.
7. a kind of preparation method of vitamin C-vitamin E soft capsule as claimed in any one of claims 1 to 6, it is characterised in that:
Include the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get described in
Capsule liquid；
(3) preparation of vitamin C-vitamin E soft capsule: being pressed into soft capsule in soft capsule molding machine for content and capsule liquid,
Obtain the vitamin C-vitamin E soft capsule.
8. a kind of preparation method of vitamin C-vitamin E soft capsule according to claim 7, it is characterised in that: the step
Suddenly the temperature of mixed sols is 70-80 DEG C in (2), time 50-70min.
9. a kind of preparation method of vitamin C-vitamin E soft capsule according to claim 7, it is characterised in that: the glue
The viscosity of cyst fluid is 18000-30000mpas.
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| CN111557446A (en) * | 2020-06-05 | 2020-08-21 | 王素荣 | Health-care capsule for middle-aged and old people and preparation method thereof |
| CN112315937A (en) * | 2020-11-05 | 2021-02-05 | 广东广发制药有限公司 | Fibrauretine soft capsule and preparation method thereof |
| CN112353778A (en) * | 2021-01-11 | 2021-02-12 | 广东银珠医药科技有限公司 | Carboxyaminetriazole soft capsule and preparation method thereof |
| CN113209041A (en) * | 2021-05-13 | 2021-08-06 | 青岛益青生物科技股份有限公司 | New formula hydroxypropyl methylcellulose hollow capsule and preparation method thereof |
| CN113209040A (en) * | 2021-05-13 | 2021-08-06 | 青岛益青生物科技股份有限公司 | Pullulan hollow capsule with new formula and preparation method thereof |
| CN113244186A (en) * | 2021-05-13 | 2021-08-13 | 青岛益青生物科技股份有限公司 | Enteric gelatin hollow capsule with new formula and preparation method thereof |
| CN113244187A (en) * | 2021-05-13 | 2021-08-13 | 青岛益青生物科技股份有限公司 | Enteric hypromellose empty capsule with new formula and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040101554A1 (en) * | 1999-05-27 | 2004-05-27 | Drugtech Corporation | Nutritional formulations |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| CN104415053A (en) * | 2013-08-23 | 2015-03-18 | 石药集团中奇制药技术（石家庄）有限公司 | Anti-oxidation and anti-aging composition |
| CN105077268A (en) * | 2015-07-10 | 2015-11-25 | 江苏艾兰得营养品有限公司 | Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation |
| CN105476020A (en) * | 2015-11-30 | 2016-04-13 | 广州市富诺生物科技有限公司 | Vitamin D3 soft capsule and preparation method thereof |
| CN105876435A (en) * | 2014-10-22 | 2016-08-24 | 会同县贤胜油业有限责任公司 | Anti-oxidizing composition soft capsule and preparation method thereof |
| CN106420816A (en) * | 2016-09-28 | 2017-02-22 | 北京瑞济善健康科技有限公司 | Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof |
-
2018
- 2018-12-26 CN CN201811603778.6A patent/CN109464418A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040101554A1 (en) * | 1999-05-27 | 2004-05-27 | Drugtech Corporation | Nutritional formulations |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| CN104415053A (en) * | 2013-08-23 | 2015-03-18 | 石药集团中奇制药技术（石家庄）有限公司 | Anti-oxidation and anti-aging composition |
| CN105876435A (en) * | 2014-10-22 | 2016-08-24 | 会同县贤胜油业有限责任公司 | Anti-oxidizing composition soft capsule and preparation method thereof |
| CN105077268A (en) * | 2015-07-10 | 2015-11-25 | 江苏艾兰得营养品有限公司 | Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation |
| CN105476020A (en) * | 2015-11-30 | 2016-04-13 | 广州市富诺生物科技有限公司 | Vitamin D3 soft capsule and preparation method thereof |
| CN106420816A (en) * | 2016-09-28 | 2017-02-22 | 北京瑞济善健康科技有限公司 | Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴克刚编著: "《食品微胶囊技术》", 31 July 2006, 中国轻工业出版社 * |
Cited By (7)
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| CN111557446A (en) * | 2020-06-05 | 2020-08-21 | 王素荣 | Health-care capsule for middle-aged and old people and preparation method thereof |
| CN112315937A (en) * | 2020-11-05 | 2021-02-05 | 广东广发制药有限公司 | Fibrauretine soft capsule and preparation method thereof |
| CN112353778A (en) * | 2021-01-11 | 2021-02-12 | 广东银珠医药科技有限公司 | Carboxyaminetriazole soft capsule and preparation method thereof |
| CN113209041A (en) * | 2021-05-13 | 2021-08-06 | 青岛益青生物科技股份有限公司 | New formula hydroxypropyl methylcellulose hollow capsule and preparation method thereof |
| CN113209040A (en) * | 2021-05-13 | 2021-08-06 | 青岛益青生物科技股份有限公司 | Pullulan hollow capsule with new formula and preparation method thereof |
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