CN102144780A - Lutein ester health care product for protecting eyesight and preparation method thereof - Google Patents
Lutein ester health care product for protecting eyesight and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a lutein ester health care product for protecting eyesight. The lutein ester health care product is prepared by taking lutein ester as a main material, and adding any one or more materials including taurine, selenium, zinc, alpha-lipoic acid, docosahexaenoic acid (DHA), vitamin A, vitamin E, vitamin B1, vitamin B2 and bilberry extract, and pharmaceutically acceptable formulation accessories. The outstanding innovation of the invention is the implementation of the method for preparing a functional eye health care product with the lutein ester instead of lutein, so that the bioavailability, the stability and the health care effect of the product are improved, and production cost can be greatly reduced. The health care product can be prepared into common dosage forms, such as tablets, capsula, granules and soft capsules. The lutein ester health care product is mainly used for the treatment on diseases, such as myopia, amblyopia, hyperopia, presbyopia, cataract, vitreous opacity, retinal pigment degeneration, macular degeneration, asthenopia, and retinopathy caused by diabetes, and the like. The lutein ester health care product adopts a unique formulation of multiple constituents, measures and mechanisms, and has significant treatment effects and excellent social and economic benefits.
Description
Technical field
The present invention relates to lutein ester health products of a kind of vision protection and preparation method thereof, belong to the technical field of health products and preparation thereof.
Background technology
Lutein is extensively to be present in natural a kind of carotenoid.Crystal lutein is generally obtained through processing steps such as organic solvent extraction, saponification, recrystallizations by marigold.Have anti-oxidant, vision protection, improve the health-care effect of angiocardiopathy, cancer-resisting.Be described as the most potential health products of 21 century.This is known by numerous consumers.The lutein health products that domestic production is at present sold, all adopting lutein crystal is that main component is made.Lutein crystal exists poor solubility, bioavilability is low, be vulnerable to most the interference of factors such as light, heat, highly acid, oxidant, reducing agent in processing and manufacturing and the storage process and reduce active ingredient, with part vitamin and mineral matter compatibility unfavorable factor such as also can degrade rapidly.Cause that the crystal lutein product stability is poor, processing cost is higher, influenced using and promoting of lutein crystal health products.The present invention aims to provide a kind of with lutein ester replacement lutein crystal, prepares the technical scheme of functional eye health products.
Lutein ester is the new resource food of China Ministry of Public Health approval, English name: LuteinEsters, chemical name: lutein dipalmitate, molecular formula: C
72H
116O
4, molecular weight: 1045.71.It is to be raw material with the marigold flower, produces through steps such as dehydration pulverizing, solvent extraction, low-molecular-weight alcohol purifying and vacuum concentrate.The raw material of domestic existing lutein ester comprises microencapsulation, the sale of water miscible raw material at present.Modern study shows that lutein ester is compared with lutein crystal, and its outstanding advantage is: 1. take in lutein ester and can reach and the equal health-care effect of absorption lutein crystal.Lutein ester in digestion and absorption process, can under the lipase effect, being hydrolyzed to rapidly before advancing human blood free lutein, thereby with the effect of the identical additional lutein of lutein crystal generation of ingesting.2. improved bioavilability.Human body, animal are better than free xanthophyll to the absorption of lutein ester.The experiment of Germany Kening Co.,Ltd shows, " lutein esterification thing decomposes the lutein bioavilability that obtains, and is higher by 61.6% than nonesterified lutein ".This may be because ester has the cause of better solubility in lipid.3. can improve the stability of product.Under environmental conditions such as identical light, heat, the stability of lutein ester is better than lutein, can alleviate the degraded of product active ingredient, is convenient to the normal temperature long preservation.4. reduce production costs.In the preparation function factor process, lutein ester does not need hydrolysis, saponification, recrystallization process, thereby the manufacturing cost of the functional food of direct employing lutein ester is obviously reduced from marigold flower.
Product of the present invention is that the commercially available lutein ester of employing is a primary raw material, makes with the natural products with health care, vitamin and mineral matter science compatibility.Look into Chinese invention patent, relevant scientific and technical literature, do not see identical and similar report with product of the present invention.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, providing a kind of is primary raw material with the lutein ester, is used for health product of sight protectio and preparation method thereof.
Embodiment of the present invention for achieving the above object is as follows:
A kind of health product with sight protectio effect is characterized in that, it is to be primary raw material with the lutein ester, adds taurine, selenium, zinc, alpha-lipoic acid, DHA (DHA), vitamin A, vitamin E, Cobastab by a certain percentage
1, Cobastab
2, any one or more than one raw material and the acceptable pharmaceutical adjunct of pharmacy are made in the Bilberry fruit P.E.
This health product raw material constitutes (in the weight portion of day dose): lutein ester 1-40mg, taurine 50-1000mg, selenium (Se meter) 10-500 μ g, zinc (Zn meter) 2-40mg, alpha-lipoic acid 50-300mg, DHA (DHA) 50-400mg, retinol1 00-900 μ gRE, vitamin E 5mg-200mg, Cobastab
10.1-30mg, Cobastab
20.1-30mg, Bilberry fruit P.E 50-300mg.
The preferred raw material of this health product constitutes (in the weight portion of day dose): lutein ester 12-20mg, taurine 200-300mg, selenium (Se meter) 50-100 μ g, zinc (Zn meter) 10-20mg, alpha-lipoic acid 100-200mg, DHA (DHA) 100-200mg, dehydroretinol 50-300 μ gRE, vitamin E 5-150mg, Cobastab
10.5-10mg, Cobastab
20.5-10mg, Bilberry fruit P.E 50-100g.
Lutein ester in this health product raw material comprises with the marigold flower being raw material, fat-soluble lutein ester that steps such as process dehydration pulverizing, solvent extraction, low-molecular-weight alcohol purifying and vacuum concentrate produce and microencapsulation, the water-soluble lutein ester of producing through special process, lutein ester content (in lutein dipalmitate) 〉=55% wherein, the anthocyanidin content in the described Bilberry fruit P.E 〉=25%.
The raw material of this health product constitutes, and can adopt above-mentioned whole 11 kinds of raw materials to make, and can be primary raw material with the lutein ester also, with taurine, selenium, zinc, alpha-lipoic acid, DHA (DHA), vitamin A, vitamin E, Cobastab
1, Cobastab
2, any one or more than one raw material is mixed with a kind of product in the Bilberry fruit P.E, the raw material consumption in this product still in the weight portion scope of above-mentioned each dose raw material day.
The auxiliary material of this health product comprises diluent, glidant, filler, cosolvent, flavor enhancement, and its supplementary product kind includes but not limited to sodium carboxymethyl starch, microcrystalline cellulose, starch, beta-schardinger dextrin-, dolomol, superfine silica gel powder, beeswax, vegetable oil, glycerine; The food-grade flavor enhancement that is added includes but not limited to that sucrose, crystal diabetin, hydroxyl isomaltulose, Stevioside, Aspartame, knob are sweet, wherein one or more of fruit essence, and the weight proportion of primary raw material and auxiliary material is 20-80: 80-20; The weight proportion of preferred primary raw material and auxiliary material is 65: 35.
The formulation of this health product includes but not limited to tablet, capsule, granule, soft capsule.
The preparation method of this health product:
The preparation method of tablet, capsule, granule: take by weighing acceptable material respectively by prescription, cross the 60-80 mesh sieve; Earlier with lutein ester, selenium, zinc, vitamin A, vitamin E, Cobastab
1, Cobastab
2Add an amount of beta-schardinger dextrin-, mix 3 times, add other raw material and auxiliary material then with the equivalent multiplication method, placed the mixer mixing 20-30 minute, above mixture is sprayed into an amount of purified water or absolute ethyl alcohol system softwood, and dry in drying machine, temperature is 45-50 ℃; Whole grain gets total compound semi-finished product; Compressing tablet, dressing routinely again, or respectively through capsule filling machine fill, the can of granule bottle placer, promptly make tablet, capsule or electuary after the assay was approved.
Preparation of soft capsule method: capsule content preparation, beeswax is added the vegetable oil 70-90 ℃ of abundant stirring and dissolving of heating, to under stirring condition, add in the oil phase suspension by the raw materials such as lutein ester that recipe quantity takes by weighing again, mix, cross the colloid mill placement and make the degassing standby; Capsule material preparation, by gelatin: glycerine: water: titanium dioxide=100: 60: 100: 0.3 part by weight takes by weighing gelatin, glycerine, purified water, titanium dioxide respectively; Water, glycerine are heated to 80 ℃, add gelatin and dissolve, add titanium dioxide again, dispersed with stirring is even, and vacuumize degassing is filtered, and gets glue, and 60 ℃ of insulations were left standstill 24 hours, made rubber; Soft capsule compacting is put into reservoir with the capsule content, uses rotation rolling capsule machine automatically, prepares soft capsule with the rotating mould platen press, carries out preliminarily dried, go-on-go then, and the absolute ethyl alcohol flushing, drying, check is packed, promptly.
The composition principle of this health product:
1, lutein ester: lutein ester in vivo under the lipase effect hydrolyzable be free lutein, and have advantages such as active ingredient easily keeps, bioavilability height, thereby reach the health-care effect that replenishes lutein.Lutein still has unique eye-protecting function except that having the same physiologically active of carotenoid.Can eliminate hydroxy radical, absorption ultraviolet ray, blue light injure amphiblestroid light, and the eyesight that prevention macula retinae degeneration (AMD) causes descends and be blind, and myopia, cataract etc. are had unique health-care effect.
2, taurine: taurine is a kind of P monoamino-acid in the body by structure called after tarine, belongs to nonprotein amino acid.Taurine can not be combined into protein with other amino acid, but exists or and bile acid formation compound with free form.Mainly be distributed in the higher tissue of excitability such as nervous system, musculature, retina and lymphocyte and the blood platelet.Taurine is a main amino acid in the ripe retina, can promote that retina grows, and alleviates ciliary spasm.
3, selenium: selenium is the highest in iris and crystalline lens intensive amount, is the important element of keeping eyesight.The normal human retina selenium content is that 7 μ g just can play a protective role, and Se content has only normal person's 1/6 in the cataract patient crystalline lens, and content of hydrogen peroxide increases 2-3 doubly than the normal person.Human body lacks selenium for a long time, can make crystalline lens produce free radical, and the glutathione peroxidase that contains selenium is reduced, and crystalline lens is subjected to the infringement of hydrogen peroxide, just causes diseases such as cataract.Mend selenium and can remove the interior free radical of crystalline lens, make to keep pellucidity in the crystalline lens, can protect retina, the fineness of reinforcing glass body improves eyesight, reduces the danger of cataract generation.
4, zinc: zinc is one of abundant element of retina intensive amount.Tissue contains zinc average out to 0.033%, and eyeball vision part is up to 4%, and retina and choroidal zinc content account for the first place again in ocular tissue.Zinc participates in the activity of a series of important meals enzymes and the metabolism and the conveying of vitamin A, keeps the normal structure form of retinal pigment epithelium, keeps normal visual function.The obvious reduction of zinc content in the crystal is the key factor that causes illness in eye to form.Zinc supplementation is significant to preventing retinal light damage and peroxidation.
5, alpha-lipoic acid: be that a kind of can the elimination quickened cell senescence and the free radical that causes a disease, in human body, after intestinal absorption, enter cell, have fat-soluble and water miscible characteristic concurrently, therefore can go everywhere without any hindrance here at whole body, arrive any one cell position, providing human body comprehensive usefulness, is a kind of " universal antioxidant ".Can when other antioxidant shortage, replace, can strengthen the effect of vitamin E, alpha-lipoic acid is made compound product with other antioxidant contents, will improve the effect of these antioxidant contents, effectively strengthen immune system in the human body, the destruction of avoiding free radical has therapeutic efficiency to ophthalmology disease and other diseases.
6, DHA (DHA): be one of the most basic composition of people's cerebral nervous system.Content in cerebral tissue is about 15%, and 60% is the DHA phospholipid molecule around amphiblestroid vision rhabdocyte.DHA is cerebral cortex and amphiblestroid important component part, with the function of neural and eyesight substantial connection is arranged.Sufficient DHA can promote the growth of optic nerve, improves visual acuity, and itself and lutein ester share can Synergistic.
7, vitamin A: the human retina periphery mainly is a rod cell, and rhodopsin is important in the rod cell, and the synthetic again of rhodopsin needs vitamin A to transform therein.As the A that is deficient in vitamin then influences the synthetic again of rhodopsin and can cause yctalopia.It is moistening and the functions such as nutriment of epithelium eubolism are provided that precorneal tear film has, as the A that is deficient in vitamin can cause mucous membrane break in the tear film to decrease and influence the metabolism of epithelial layer, formation xerophthalmia.During wretched insufficiency, yctalopia, eye dryness, ulcer are shed tears, are kept in dark place, even blind.Vitamin A also can influence the retina normal physiological function in addition, and visual performance descends, and eyes are tired easily, and replenishing vitamins A can make eyes bright, prevents and treats eye illness and takes place.
8, vitamin E: vitamin E can be protected the unrighted acid of multivalence to avoid oxidation and destroy, and the peroxidating of lipid is brought out in prevention and prevention, reduces the generation of peroxidating material, keeps biomembranous normal configuration.
9, vitamin B1 and B2: vitamin B1 is the requisite catalyst of glucide metabolism, and shortage will make optic nerve suffer damage, causing malnutrition property amblyopia, distinguish the look function reduction for two, eyesight is fuzzy gradually, even optic atrophy, can cause nonvolatil hypopsia.During Vitamin B2 deficiency, blear-eye can appear, conjunctiva blood vessel dilatation, and the cornea peripheral vasodilation, thus affect one's power of vision.
10, Bilberry fruit P.E: cowberry is blueberry (Blueberry) again, belongs to Ericaceae (Ericaceae) plant, and its fruit is rich in anthocyanidin (being called for short VMA) glucoside, is a kind of water-soluble biological flavones.Has stronger antioxidant action; the protection eyes are avoided free radical injury; can activate retina, strengthen eyesight, improve the retina circulation, remove toxic chemical substance in the retina, increase the generation of retina purpurine; improve the effect of macula lutea recovery time and night vision; can effectively keep the health of eyes, prevent and treat the generation of eye illness.
The present invention is a primary raw material with the lutein ester, is equipped with above-mentioned other all or part of nutritional labeling organic complexes, has synergistic function between each nutritional labeling.This product mainly is mainly used in myopia, amblyopia, long sight, presbyopia, cataract, vitreous opacity, retinal pigment degeneration, macular degeneration sex change, visual fatigue and PVR that diabetes caused etc.Take for a long time simultaneously and also have anti-oxidant, anti-ageing, as to protect cardiovascular and cerebrovascular, cancer-resisting function.Product has no side effect, and edible safety is effective.
The invention has the beneficial effects as follows:
1, provides the innovative approach for preparing functional eye health products with the alternative lutein of lutein ester, helped improving bioavilability, stability and the health-care effect of product.
2, added the required various nutrients of eye health in the prescription, these nutritional labelings have synergy in the biochemical process of amphiblestroid photosensory cell, give eyes and comprehensively protect, and have more protection than simple Chinese medicine preparation and render a service.
3, product of the present invention not only can be used for health food, also can be applicable to field of medicaments.
4, reduce production costs, the production of lutein ester does not need hydrolysis, saponification, recrystallization process, can obviously reduce manufacturing cost, has good social benefit and economic benefit.
The specific embodiment
In order to help those skilled in the art more fully to understand the present invention, be described in detail the specific embodiment of the present invention, but the right that cited embodiment does not limit the present invention in any way.
Embodiment 1: the lutein ester soft capsule preparation
Prescription: lutein ester 10g, taurine 125g, selenide of carragheen 1.25g, zinc lactate 24g, alpha-lipoic acid 50g, DHA 50g, retinol1 50mg, vitamin E2 5g, Cobastab
12.5g, Cobastab
22.5g, Bilberry fruit P.E 40g, soybean salad oil 160g, beeswax 10g.Make 1000, every 0.5g, 2 of every days.
Technology: capsule content preparation, beeswax is added the soybean salad oil 70-90 ℃ of fully dissolving of heating, will under agitation add by the raw materials such as lutein ester that recipe quantity takes by weighing in the above-mentioned oil phase suspension again, mix, cross colloid mill, placement makes it to outgas standby; Capsule material preparation, by gelatin: glycerine: water: titanium dioxide=100: 60: 100: 0.3 part by weight takes by weighing gelatin, glycerine, purified water, titanium dioxide respectively; Water, glycerine are heated to 80 ℃, add gelatin and dissolve, add titanium dioxide again, dispersed with stirring is even, and vacuumize degassing is filtered, and gets glue, and 60 ℃ of insulations were left standstill 24 hours, made rubber; Soft capsule compacting is put into reservoir with the capsule content, uses rotation rolling capsule machine automatically, prepares soft capsule with the rotating mould platen press, carries out preliminarily dried, go-on-go then, and the absolute ethyl alcohol flushing, drying, is packed, promptly at check.
Embodiment 2: the preparation of lutein ester capsule
Prescription: lutein ester micro-capsule powder 10g, Bilberry fruit P.E 80g, taurine 135g, selenide of carragheen 1.25g, zinc lactate 24g, DHA 50g, microcrystalline cellulose 20g, beta-schardinger dextrin-20g, starch 60g.Make 1000, every 0.4g, 2 of every days.
Technology: take by weighing acceptable material respectively by prescription, cross the 60-80 mesh sieve; Earlier lutein ester micro-capsule powder, selenide of carragheen, zinc lactate are added an amount of beta-schardinger dextrin-, mix 3 times with the equivalent multiplication method, add other raw material and auxiliary material then, placed the mixer mixing 20-30 minute, above mixture is sprayed into an amount of purified water or absolute ethyl alcohol system softwood, dry in drying machine, temperature is 45-50 ℃; Whole grain gets total compound semi-finished product; Press the capsule conventional method again and fill through capsule filling machine respectively, the capsule polishing promptly gets capsule after check, the packing.
Embodiment 3: the lutein ester preparation of granules
Prescription: lutein ester micro-capsule powder 20g, taurine 155g, selenide of carragheen 1.25g, zinc lactate 24g, alpha-lipoic acid 200g, DHA 100g, retinol1 50mg, vitamin E2 5g, Cobastab
12.5g, Cobastab
22.5g, Bilberry fruit P.E 200g, beta-schardinger dextrin-50g, sucrose 660g, microcrystalline cellulose 50g, sodium carboxymethylcellulose 502g, Stevioside 0.7g, fruit essence 7g.Make 1000 bags, every bag of 2g, 2 bags of every days.
Technology: take by weighing acceptable material respectively by prescription, cross the 60-80 mesh sieve; Earlier with lutein ester capsule powder, selenium, zinc, vitamin A, vitamin E, Cobastab
1, Cobastab
2Add an amount of beta-schardinger dextrin-, mix 3 times, add other raw material and auxiliary material then with the equivalent multiplication method, placed the mixer mixing 20-30 minute, above mixture is sprayed into an amount of purified water or absolute ethyl alcohol system softwood, and dry in drying machine, temperature is 45-50 ℃; Whole grain gets total compound semi-finished product; Granular preparation method routinely again, with the can of granule bottle placer, check, packing, granule gets product.
Embodiment 4: the lutein ester preparation tablets
Prescription: lutein ester micro-capsule powder 10g, Bilberry fruit P.E 100g, taurine 200g, selenide of carragheen 1.25g, zinc lactate 24g, DHA 50g, beta-schardinger dextrin-50g, dextrin 65g.Make 1000, every 0.5g, 2 of every days.
Technology: take by weighing acceptable material respectively by prescription, cross the 60-80 mesh sieve; Earlier lutein ester micro-capsule powder, selenide of carragheen, zinc lactate are added an amount of beta-schardinger dextrin-, mix 3 times with the equivalent multiplication method, add other raw material and auxiliary material then, placed the mixer mixing 20-30 minute, above mixture is sprayed into an amount of purified water or absolute ethyl alcohol system softwood, dry in drying machine, temperature is 45-50 ℃; Whole grain gets total compound semi-finished product; Compressing tablet, dressing routinely again, check, packing promptly gets tablet.
The implementation result example:
It is as follows that product of the present invention is taken effect:
1,1000 routine visual fatigue experimenters, be divided into examination at random and take group and control group, examination is taken group and is taken this tablet as requested after 30 days, the symptom total mark is obviously improved (P＜0.01), duration of photopic vision is 0.71+0.02 (P＜0.01), average duration of photopic vision rises to 0.15+0.08, wherein total effective rate 66.00% (P＜0.05).Before and after the examination of this tablet was taken, routine blood test, routine urinalysis, just routine and blood biochemistry index all in normal range (NR), illustrated that preparation of the present invention is to the healthy no any harmful effect of experimenter.
2,1000 routine near-sighted experimenters took granule of the present invention after 30 days, and this product effectively improves the distant vision situation of near-sighted vulnerable period, early stage myopia and low myopia, efficient 79.12% (P＜0.05) that reaches.But this improvement is generally between 3-4 capable (logarithmic visual acuity chart).
3, the experimenter of 50 routine aging macula retinae district pathologies, the age is in 60-83 year, the male sex's 23 examples, women's 27 examples.All be diagnosed as the patches of macula sex change through hospital before being tried, take soft capsule of the present invention respectively after 15 weeks, the pigment content of portion of the yellow class of retina has tangible increase, and impaired retinal tissue has clear improvement.
Claims (9)
1. health product with sight protectio effect; it is characterized in that the raw material of this health product constitutes (in the weight portion of day dose): lutein ester 1-40mg, taurine 50-1000mg, selenium (Se meter) 10-500 μ g, zinc (Zn meter) 2-40mg, alpha-lipoic acid 50-300mg, DHA (DHA) 50-400mg, retinol1 00-900 μ gRE, vitamin E 5mg-200mg, Cobastab
10.1-30mg, Cobastab
20.1-30mg, Bilberry fruit P.E 50-300mg.
2. constitute by its preferred raw material of the described health product of claim 1; it is characterized in that its preferred raw material constitutes (in the weight portion of day dose): lutein ester 12-20mg, taurine 200-300mg, selenium (Se meter) 50-100 μ g, zinc (Zn meter) 10-20mg, alpha-lipoic acid 100-200mg, DHA (DHA) 100-200mg, dehydroretinol 50-300 μ gRE, vitamin E 5-150mg, Cobastab
10.5-10mg, Cobastab
20.5-10mg, Bilberry fruit P.E 50-100g.
3. by the raw material in claim 1, the 2 described health products, it is characterized in that, described lutein ester comprises with the marigold flower being raw material, through the fat-soluble lutein ester of step productions such as dehydration pulverizing, solvent extraction, low-molecular-weight alcohol purifying and vacuum concentrate and microencapsulation, the water-soluble lutein ester of producing through special process, lutein ester content (in lutein dipalmitate) 〉=55%; Anthocyanidin content in the described Bilberry fruit P.E 〉=25%.
4. press the prescription of claim 1,2 described health products; it is characterized in that; the raw material of this health product constitutes; it can adopt claim 1,2 described whole 11 kinds of raw materials to make; can with the lutein ester primary raw material also, with taurine, selenium, zinc, alpha-lipoic acid, DHA (DHA), vitamin A, vitamin E, Cobastab
1, Cobastab
2, any one or more than one raw material is mixed with a kind of product in the Bilberry fruit P.E, its raw material consumption still claim 1,2 described each raw material day dose the weight portion scope in.
5. press the auxiliary material of claim 1,2 described health products, it is characterized in that, it comprises diluent, glidant, filler, cosolvent, flavor enhancement, and its supplementary product kind includes but not limited to sodium carboxymethyl starch, microcrystalline cellulose, starch, beta-schardinger dextrin-, dolomol, superfine silica gel powder, beeswax, vegetable oil, glycerine; The food-grade flavor enhancement that is added includes but not limited to that sucrose, crystal diabetin, hydroxyl isomaltulose, Stevioside, Aspartame, knob are sweet, in the fruit essence one or more, and the weight proportion of primary raw material and auxiliary material is 20-80: 80-20; The weight proportion of preferred primary raw material and auxiliary material is 65: 35.
6. the formulation of this health product is characterized in that, it includes but not limited to tablet, capsule, granule, soft capsule.
7. the preparation method of tablet, capsule, granule in these health products is characterized in that, it is to take by weighing acceptable material respectively by prescription, crosses the 60-80 mesh sieve; Earlier with lutein ester, selenium, zinc, vitamin A, vitamin E, Cobastab
1, Cobastab
2Add an amount of beta-schardinger dextrin-, mix 3 times, add other raw material and auxiliary material then with the equivalent multiplication method, placed the mixer mixing 20-30 minute, above mixture is sprayed into an amount of purified water or absolute ethyl alcohol system softwood, and dry in drying machine, temperature is 45-50 ℃; Whole grain gets total compound semi-finished product; Compressing tablet, dressing routinely again, or respectively through capsule filling machine fill, the can of granule bottle placer, promptly make tablet, capsule or electuary after the assay was approved.
8. preparation of soft capsule method in this health product: it is characterized in that, it is that beeswax is added the vegetable oil 70-90 ℃ of abundant stirring and dissolving of heating, to under stirring condition, add in the oil phase suspension by the raw materials such as lutein ester that recipe quantity takes by weighing again, mix, crossing colloid mill places, make it the degassing, it is standby to make the capsule content; By gelatin: glycerine: water: titanium dioxide=100: 60: 100: 0.3 part by weight takes by weighing gelatin, glycerine, purified water, titanium dioxide respectively, water, glycerine are heated to 80 ℃, adding gelatin dissolves, add titanium dioxide again, dispersed with stirring is even, vacuumize degassing, filter, get glue, 60 ℃ of insulations were left standstill 24 hours, and it is standby to make the capsule material; Soft capsule compacting is put into reservoir with the capsule content, uses rotation rolling capsule machine automatically, prepares soft capsule with the rotating mould platen press, carries out preliminarily dried, go-on-go then, and the absolute ethyl alcohol flushing, drying, check is packed, promptly.
9. the purposes of this health product is characterized in that, this health product is mainly used in myopia, amblyopia, long sight, presbyopia, cataract, vitreous opacity, retinal pigment degeneration, macular degeneration sex change, visual fatigue and PVR that diabetes caused.
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| CN103735733A (en) * | 2013-12-30 | 2014-04-23 | 杭州海杭生物医药科技有限公司 | Compound preparation containing lutein ester and preparation method thereof |
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| CN104224890A (en) * | 2014-07-29 | 2014-12-24 | 中宏生物工程有限责任公司 | Lutein soft capsule and preparation method thereof |
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Application publication date: 20110810 |