CN106109737A - A kind of antioxidative nutritional preparation and preparation method thereof - Google Patents
A kind of antioxidative nutritional preparation and preparation method thereof Download PDFInfo
- Publication number
- CN106109737A CN106109737A CN201610506584.9A CN201610506584A CN106109737A CN 106109737 A CN106109737 A CN 106109737A CN 201610506584 A CN201610506584 A CN 201610506584A CN 106109737 A CN106109737 A CN 106109737A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- preparation
- vitis viniferae
- green tea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
A kind of antioxidative nutritional preparation, by hydroxyl isomaltulose, Semen Vitis viniferae extract, green tea extract, lycopene, phylloxanthin, Haematocoocus Pluvialls extract, organic selenium, microcrystalline Cellulose, silicon dioxide, magnesium stearate, edible essence forms, by weight: hydroxyl isomaltulose 20～50 parts, Semen Vitis viniferae extract 1～20 parts, green tea extract 1～15 parts, lycopene 0.1～2 parts, phylloxanthin 0.1～2 parts, Haematocoocus Pluvialls extract 1～10 parts, organic selenium 0.1～8 parts, microcrystalline Cellulose 1～30 parts, silica 1～10 parts, magnesium stearate 0.01～0.1 part, edible essence 0.1～1 part.The preparation method of a kind of antioxidation nutritional preparation, comprises the steps: that (1) weighs with the most mixed, and (2) pelletize, and (3) always mix, (4) tabletting, coating, packaging, obtain finished product.
Description
Technical field
The present invention relates to a kind of nutritional preparation and preparation method thereof, especially a kind of antioxidative nutritional preparation and preparation thereof
Method.
Background technology
Medical circle thinks that the aging of human body is to be caused by destructions various produced by the peroxidization of free radical.
After human body enters certain age level, internal free radical will increase, the peroxidization that free radical is caused also with
Increase.The increase of peroxidization, can make the content of internal monoamine oxidase, MAO (MAO) increase, cause monoamine oxidative dehydrogenation anti-
Should strengthen, and then the norepinephrine of the hormone with monoamine as main component and neurotransmitter such as catecholamines can be made
(NAD), epinephrine (AD), dopamine (DA) and cholinergic neurotransmitter acetylcholine (ACH), inhibitory neurotransmitter 5-
Hydroxytryptamines (5-HT) etc. lost efficacy.Therefore, the reinforcement of monoamine oxidative dehydrogenation can cause physiological brain functional deterioration, obstacle and
Dystropy, promotes human senility.The increase of peroxidization, also can make lens the pathological changes such as retina is fuzzy occur,
Induce senile visual disorder (such as dim eyesight, cataract etc.).
The increase of peroxidization, it is possible to make produced lipid peroxide (LPO) in peroxidization increase.LPO's
Increase can make the superoxide dismutase (SOD) with suppression and defence free radical damage effect reduce, and makes cell biological film crisp
Property increase and be more subject to destroy.LPO also can be done directly on memebrane protein, makes kytoplasm ribonucleic acid (RNA) persistently reduce, RNA
Homergy needs can not be maintained, cause organ-tissue cell senescence with dead.Wherein, may result in neuronal cell quantity obvious
Reduce, cause sensation and hypomnesis, heavy and dysnoesia.And the increase of lipid peroxidation, lipid can be made
Peroxidization end product malonaldehyde (MDA) increases.Malonaldehyde can cause the macromolecular substances such as protein, nucleic acid to produce crosslinking
Polymerization.Therefore, the increase of malonaldehyde can make the cross-linked polymeric of the collagen protein in protein increase, and can make the dissolving of collagen protein
Property and elastic reduce and hydratability goes down, skin can be caused to lose tension force and wrinkle increases, lipofuscin is piled up and sclerotin
Regeneration capacity weakens.The above-mentioned various destructions of free radical peroxidization will cause the groups such as human body skin, internal organs, brain
Knit organ senescence and cause multiple serious disease.
Along with environmental pollution, life stress and bad living habit increase, only the regulation by body interior is removed
Free radical is the most inadequate.Our people's income and living standard improve constantly, and people are to " food " the biggest existing change in idea, logical
Toning research and development are existing, and in 12000 plurality kinds of health care food of country's approved, existing more than 120 product has anti-oxidation function.Mesh
Front domestic oxidation-resisting health-care product specifically includes that various vitamins, soybean isoflavone, minerals, Chinese medicine class etc..
Above-mentioned oxidation resistant product, is all antioxidation, slow down aging, but the constituent of these products from different perspectives
Single, and the action principle of every kind of antioxidant is not quite similar, and uses single component antioxidant effect to can't bear substantially.
Summary of the invention
The present invention to provide a kind of can the most coefficient, antioxidation is clear and definite, safe without toxic side effect,
And cheap antioxidation nutritional preparation.
The technical problem to be solved is to provide a kind of antioxidative nutritional preparation and preparation method thereof.
The technical solution adopted in the present invention is:
A kind of antioxidative nutritional preparation, by hydroxyl isomaltulose, Semen Vitis viniferae extract, green tea extract, lycopene,
Phylloxanthin, Haematocoocus Pluvialls extract, organic selenium, microcrystalline Cellulose, silicon dioxide, magnesium stearate, edible essence form, by weight
Gauge: hydroxyl isomaltulose 20～50 parts, Semen Vitis viniferae extract 1～20 parts, green tea extract 1～15 parts, lycopene 0.1～
2 parts, phylloxanthin 0.1～2 parts, Haematocoocus Pluvialls extract 1～10 parts, organic selenium 0.1～8 parts, microcrystalline Cellulose 1～30 parts,
Silica 1～10 parts, magnesium stearate 0.01～0.1 part, edible essence 0.1～1 part.
A kind of preparation method of antioxidation nutritional preparation,
(1) weigh with just mixed: weigh by weight hydroxyl isomaltulose 20～50 parts, Semen Vitis viniferae extract 1～20 parts,
Green tea extract 1～15 parts, lycopene 0.1～2 parts, phylloxanthin 0.1～2 parts, Haematocoocus Pluvialls extract 1～10 parts, have
Machine selenium 0.1～8 parts, microcrystalline Cellulose 1～30 parts, silica 1～10 parts, put into mixing 20～30 points in mixer successively
Clock, crosses 60 mesh sieves；
(2) pelletize: the most mixed powder puts into efficient wet granulator, and uses carboxymethylcellulose sodium solution as binding agent system
Grain (wherein sodium carboxymethyl cellulose in carboxymethylcellulose sodium solution: dehydrated alcohol: water is 1:20:10, first by carboxymethyl cellulose
Element sodium is soluble in water, adds dehydrated alcohol in water after being completely dissolved), it is dry that wet granular is transferred to boiling after oscillating granulator
Dry machine is dried, and dry granule is through Fast granulate machine granulate；
(3) always mix: dry granule is put into mixer, added magnesium stearate 0.01-0.1 part by equal increments method, eaten
Essence 0.1-1 part, total mixed 20～30 minutes；
(4) tabletting, coating, packaging: gained granule is carried out tabletting, coating, then packs, obtain finished product.
Beneficial effect
The invention have the benefit that
1, antioxidative nutritional preparation it is applicable to first by astaxanthin, procyanidin, resveratrol, tea polyphenols, tomato red
The antioxidation trophic factors such as element, phylloxanthin, organic selenium organically blend, it is achieved that seven big polishings of top antioxidant, this
After a little Antioxidative Factors are absorbed by the body, play features at the different histoorgan of human body and cell site, and assist mutually
With strengthening antioxidation, non-single antioxidant health benefit can ratio.
2, Haematocoocus Pluvialls extract, Semen Vitis viniferae extract, green tea extract processing technique are simple, it is easy to operation, activity
Composition enriches.
3, clinical and experimental study proves, nutritional preparation effect of the present invention is notable.
4, this prescription raw material derives from food, safe and free of toxic and side effects.
5, production technology is simple, easy to operate, and product stability is good, is the preferable processing of large-scale industrial production
Technology.
Detailed description of the invention
A kind of antioxidative nutritional preparation preparation method embodiment is as follows:
Embodiment 1
The production process of a kind of antioxidative nutritional preparation is made up of following steps:
1, weigh with the most mixed: weigh hydroxyl isomaltulose 20kg, Semen Vitis viniferae extract 10kg, green tea extraction by weight
Thing 7kg, lycopene 1kg, phylloxanthin 0.8kg, Haematocoocus Pluvialls extract 4kg, organic selenium 3.8kg, microcrystalline Cellulose 5kg,
Silicon dioxide 5kg, mixes 20 minutes in putting into mixer successively, crosses 60 mesh sieves；
2, pelletize: the most mixed powder puts into efficient wet granulator, and uses carboxymethylcellulose sodium solution as binding agent system
Grain (wherein sodium carboxymethyl cellulose in carboxymethylcellulose sodium solution: dehydrated alcohol: water is 1:20:10, first by carboxymethyl cellulose
Element sodium is soluble in water, adds dehydrated alcohol in water after being completely dissolved), it is dry that wet granular is transferred to boiling after oscillating granulator
Dry machine is dried, and dry granule is through Fast granulate machine granulate；
3, always mix: dry granule is put into mixer, add magnesium stearate 0.01 part, edible essence by equal increments method
0.1 part, total mixed 20 minutes；
4, tabletting, coating, packaging: gained granule is carried out tabletting, tablet weight 1.0g, by element coating tablets, then packs,
Packing specification 120 slice/bottle, obtains finished product.
Embodiment 2
The production process of a kind of antioxidative nutritional preparation is made up of following steps:
1, weigh with the most mixed: weigh hydroxyl isomaltulose 30kg, Semen Vitis viniferae extract 20kg, green tea extraction by weight
Thing 5kg, lycopene 0.5kg, phylloxanthin 0.5kg, Haematocoocus Pluvialls extract 5kg, organic selenium 2kg, microcrystalline Cellulose 7kg,
Silicon dioxide 7kg, mixes 20 minutes in putting into mixer successively, crosses 60 mesh sieves；
2, pelletize: the most mixed powder puts into efficient wet granulator, and uses carboxymethylcellulose sodium solution as binding agent system
Grain (wherein sodium carboxymethyl cellulose in carboxymethylcellulose sodium solution: dehydrated alcohol: water is 1:20:10, first by carboxymethyl cellulose
Element sodium is soluble in water, adds dehydrated alcohol in water after being completely dissolved), it is dry that wet granular is transferred to boiling after oscillating granulator
Dry machine is dried, and dry granule is through Fast granulate machine granulate；
3, always mix: dry granule is put into mixer, add magnesium stearate 0.01 part, edible essence by equal increments method
0.1 part, total mixed 20 minutes；
4, tabletting, coating, packaging: gained granule is carried out tabletting, tablet weight 1.0g, by element coating tablets, then packs,
Packing specification 120 slice/bottle, obtains finished product.
Embodiment 3
The production process of a kind of antioxidative nutritional preparation is made up of following steps:
1, weigh with the most mixed: weigh hydroxyl isomaltulose 40kg, Semen Vitis viniferae extract 5kg, green tea extraction by weight
Thing 10kg, lycopene 2kg, phylloxanthin 1kg, Haematocoocus Pluvialls extract 5kg, organic selenium 8kg, microcrystalline Cellulose 15kg, two
Silicon oxide 10kg, mixes 20 minutes in putting into mixer successively, crosses 60 mesh sieves；
2, pelletize: the most mixed powder puts into efficient wet granulator, and uses carboxymethylcellulose sodium solution as binding agent system
Grain (wherein sodium carboxymethyl cellulose in carboxymethylcellulose sodium solution: dehydrated alcohol: water is 1:20:10, first by carboxymethyl cellulose
Element sodium is soluble in water, adds dehydrated alcohol in water after being completely dissolved), it is dry that wet granular is transferred to boiling after oscillating granulator
Dry machine is dried, and dry granule is through Fast granulate machine granulate；
3, always mix: dry granule is put into mixer, add magnesium stearate 0.01 part, edible essence by equal increments method
0.1 part, total mixed 20 minutes；
4, tabletting, coating, packaging: gained granule is carried out tabletting, tablet weight 1.0g, by element coating tablets, then packs,
Packing specification 120 slice/bottle, obtains finished product.
Embodiment 4
The production process of a kind of antioxidative nutritional preparation is made up of following steps:
1, weigh with the most mixed: weigh hydroxyl isomaltulose 50kg, Semen Vitis viniferae extract 20kg, green tea extraction by weight
Thing 15kg, lycopene 2kg, phylloxanthin 2kg, Haematocoocus Pluvialls extract 10kg, organic selenium 8kg, microcrystalline Cellulose 15kg, two
Silicon oxide 10kg, mixes 20 minutes in putting into mixer successively, crosses 60 mesh sieves；
2, pelletize: the most mixed powder puts into efficient wet granulator, and uses carboxymethylcellulose sodium solution as binding agent system
Grain (wherein sodium carboxymethyl cellulose in carboxymethylcellulose sodium solution: dehydrated alcohol: water is 1:20:10, first by carboxymethyl cellulose
Element sodium is soluble in water, adds dehydrated alcohol in water after being completely dissolved), it is dry that wet granular is transferred to boiling after oscillating granulator
Dry machine is dried, and dry granule is through Fast granulate machine granulate；
3, always mix: dry granule is put into mixer, add magnesium stearate 0.01 part, edible essence by equal increments method
0.1 part, total mixed 20 minutes；
4, tabletting, coating, packaging: gained granule is carried out tabletting, tablet weight 1.0g, by element coating tablets, then packs,
Packing specification 120 slice/bottle, obtains finished product.
Embodiment 5
The production process of a kind of antioxidative nutritional preparation is made up of following steps:
1, weigh with the most mixed: weigh hydroxyl isomaltulose 20kg, Semen Vitis viniferae extract 5kg, green tea extraction by weight
Thing 10kg, lycopene 2kg, phylloxanthin 2kg, Haematocoocus Pluvialls extract 5kg, organic selenium 2kg, microcrystalline Cellulose 3kg, dioxy
SiClx 3kg, mixes 20 minutes in putting into mixer successively, crosses 60 mesh sieves；
2, pelletize: the most mixed powder puts into efficient wet granulator, and uses carboxymethylcellulose sodium solution as binding agent system
Grain (wherein sodium carboxymethyl cellulose in carboxymethylcellulose sodium solution: dehydrated alcohol: water is 1:20:10, first by carboxymethyl cellulose
Element sodium is soluble in water, adds dehydrated alcohol in water after being completely dissolved), it is dry that wet granular is transferred to boiling after oscillating granulator
Dry machine is dried, and dry granule is through Fast granulate machine granulate；
3, always mix: dry granule is put into mixer, add magnesium stearate 0.01 part, edible essence by equal increments method
0.1 part, total mixed 20 minutes；
4, tabletting, coating, packaging: gained granule is carried out tabletting, tablet weight 1.0g, by element coating tablets, then packs,
Packing specification 120 slice/bottle, obtains finished product.
In the described each component of one of embodiment 1～5:
Described Semen Vitis viniferae extract is prepared by following method:
(1) weigh a certain amount of Semen Vitis viniferae, after vacuum drying, pulverize with Chinese medicine grinder, be 80 mesh to fineness degree；
(2) weighing a certain amount of Semen Vitis viniferae powder, add the ethanol solution that concentration is 70% (v/v), solid-liquid ratio is 1:10 (w/v)
Extracting, Extracting temperature is 30 DEG C, and extraction time is 3h；
(3), after extracting once, it is centrifuged 4min with 3000r/min, takes supernatant；
(4) precipitate is re-dissolved in the ethanol solution of same concentrations, again extracts with identical condition, after being centrifuged, take
Clear liquid；
(5) supernatant of twice extraction is mixed, be dried after concentration.
Described green tea extract is prepared by following method:
(1) weigh a certain amount of green tea, pulverize with Chinese medicine grinder, be 80 mesh to fineness degree；
(2) weighing a certain amount of green tea powder, add the ethanol solution that concentration is 70% (v/v), solid-liquid ratio is 1:15 (w/v),
Extracting in 80 DEG C of water-baths, extraction time is 4h；
(3), after extracting once, it is centrifuged 5min with 4000r/min, takes supernatant；
(4) precipitate is re-dissolved in the ethanol solution of same concentrations, again extracts with identical condition, after being centrifuged, take
Clear liquid；
(5) supernatant of twice extraction is mixed, be dried after concentration.
Described Haematocoocus Pluvialls extract is prepared by following method:
(1) weigh commercially available haematococcus pluvialis powder (purchased from Jing Zhou, Hubei Province natural astaxanthin company limited), add acetic acid second
Ester is as Extraction solvent, and solid-liquid ratio is 1:40 (w/v), and Extracting temperature is 50 DEG C, and extraction time is 3h；
(2), after extracting once, it is centrifuged 4min with 4000r/min, takes supernatant；
(3) precipitate is re-dissolved in ethyl acetate, extracts second time with identical condition, after being centrifuged, take supernatant；
(4) supernatant of twice extraction is mixed, be dried after concentration.
The described each amounts of components of one of embodiment 1～5 is increased or decreased according to same ratio, the weight portion of each component of gained
Number relation belongs to can also root in protection scope of the present invention, and each component of the nutritional preparation of this improvement cardiovascular and cerebrovascular disease
Adjuvant and the additive of reasonable volume scope is included, such as maltodextrin, starch, xanthan gum, melon according to techniques well known general knowledge
That locust beam gum, sucrose fatty acid ester, magnesium stearate, oligofructose, oligomeric xylose, oligomeric isomaltose, mannitol, different Fructus Hordei Germinatus ketone
In sugar, aspartame, sucralose etc. 1～the combination in any of 10 kind.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, simplify, all should be
The substitute mode of equivalence, within being included in protection scope of the present invention.
The composition principle inventing described antioxidative nutritional preparation is:
Semen Vitis viniferae extract is one of the most efficient antioxidant of plant origin of finding so far, former containing high-load
Anthocyanidin and resveratrol.Internal and in vitro tests shows that the antioxidant effect of Semen Vitis viniferae extract is vitamin C and Wei Sheng
30-50 times of element E.Superpower antioxidation efficiency has the strength effect removed free radical, improve body immunity.Semen Vitis viniferae essence
China GrapeSeed Extract containing abundant bioflavonoids, be the elite molecule of strength, for free radical resisting (free radical) with
Safeguard the health of microfilament blood vessel.Free radical is one of major reason causing aging and many diseases, and tool estimates about 80%-
Aging, the degenerative disorders of 90% are all relevant with free radical, so, Semen Vitis viniferae extract, to human body antioxidation, improves immunity
Power has splendid effect.Grape pip procyanidin can pass through blood brain barrier (Blood-brain barrier) easily,
It is a kind of particularly effective antioxidant, and it can be highly concentrated in brain and nervous tissue, and this characteristic makes
It becomes the antioxidant that brain is ideal.It can improve the microcirculqtory system poor circulation of brain and heart；
Change vulnerability and the permeability (for diabetics) of microfilament blood vessel；Improve long-term limb end tremulous pulse or venous blood flow not
Foot；Change platelet aggregation and the characteristic of microfilament Ink vessel transfusing blood flow.And the effect of free radical and ferment makes microvascular elastic fine
Dimension (collagen protein and elastin laminin) is destroyed, retina microfilament vascular lesion, swollen lymph node, varicosis, and Semen Vitis viniferae
Procyanidin can be effectively improved above disease, and reduces aging sign and the attack rate of degenerative disorders.
Green tea extract tea polyphenols is the All Pure Nature antioxidant food in Folium Camelliae sinensis, has strong anti-oxidation ability.Tea polyphenols
(Tea Polyphenols) is the general name of Polyphenols of Tea, including flavanol compound, anthocyanin class, flavonoid, flavonol
Class and phenolic acids etc..The removing harmful free radicals that tea polyphenols energy is extremely strong, blocks lipid peroxidation process, improves the work of human enzymes
Property, thus play effect of mutation, anticancer.First, prevention and cure of cardiovascular disease, blood fat reducing, prevention liver and coronary artery
Atherosis.Tea polyphenols is to body fat metabolism important role.The cholesterol of human body, triglyceride equal size are high, blood vessel
Inwall lipidosis, forms atheromatous plaque etc. and can cause cardiovascular disease after vascular smooth muscle cell curing.Tea polyphenols,
Especially the catechins ECG in tea polyphenols and EGC and oxidation product theaflavin etc. thereof, contribute to suppressing this plaque-like hypertrophy, make
Forming the Fibrinogen reduction that blood clotting viscosity strengthens, blood coagulation becomes clear, thus suppresses atherosclerosis.Secondly, blood pressure lowering.Tea
Polyphenol has the effect of stronger suppression transaminase activity, thus can play the effect reducing or keeping blood pressure stabilization.Again,
Blood sugar lowering.Tea polyphenols has regulation effect to the metabolism obstacles of blood glucose of human body, can reduce blood sugar level, thus effectively prevents and control
Treat diabetes.
Lycopene (lycopene), is the natural pigment of a Carotenoids.Can effectively protect cardiovascular.Fructus Lycopersici esculenti
Red pigment can suppress the formation of arteriosclerosis, improves the cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, coronary heart disease.Due to lycopene
The oxidation of low density lipoprotein, LDL in the anti-hemostasis of energy, thus the ill danger of atherosclerosis and coronary heart disease can be reduced.There is scholar
Reach a conclusion according to 10 the national research reports in Europe, eat the tomato product at least containing 40 milligrams of lycopenes every day, can be bright
The aobvious risk reducing generation coronary heart disease.Male body can be protected healthy.Having in male body, lycopene is mainly distributed on testis
Ball, prostatitis gap, adrenal gland, liver etc. are organized, and can help prevention and improve the urinary system disease such as prostatic hyperplasia, prostatitis
Disease, and it is favorably improved mankind spermatozoon quality, reduce infertility risk.One research from Harvard University finds: class is recklessly
Radix Raphani element has certain relation with carcinoma of prostate.In the research of carotenoid, only lycopene has clear and definite protection work
With.Male takes the lycopene (every day more than 6.5 milligrams) of maximal dose every day in the diet compared with taking those at least, can
So that the dangerous minimizing 21% that carcinoma of prostate occurs.Can prevent or improve cataract and treating senile maculopathy.Cataract and
Senile degeneration of macula is the ophthalmic diseases that old people is common.According to Univ Wisconsin-Madison USA Ma Ruisi Paar completely, with
The people that in blood, lycopene concentration is low compares, and in blood, lycopene concentration height person occurs the chance of senile degeneration of macula can
Reduce 50%.
Phylloxanthin is a kind of natural materials being widely present in the plants such as vegetable, flowers, fruit, is a kind of important resisting
Oxidant, for a member of carotenoid family (the natural fat-soluble pigment found in one group of plant), has another name called " plant corpus luteum
Element ".Phylloxanthin and zeaxanthin constitute the key component of the plant pigment such as veterinary antibiotics, flowers, are also that human eye retina is yellow
The primary pigments of spot region.The eyes of the mankind contain the phylloxanthin of a large amount, and this element is that human body cannot manufacture, it is necessary to by taking the photograph
Entering phylloxanthin to supplement, if lacking this element, eyes will be blind.Protect the eyes from phototoxis, delay the old of eyes
Change and prevent pathological changes: ultraviolet and blue light in sunlight enter eyes and can produce a large amount of free radical, cause cataract, macular area
Degenerate, even cancer.Ultraviolet typically can be filtered out by cornea and crystalline lens, but blue light can penetrate eyeball and go directly retina
And macula lutea, the phylloxanthin in macula lutea then can filter out blue light, it is to avoid the blue light infringement to eyes.The fatty outer layer of macular area is special
Being easily subject to the oxidative damage of sunlight, therefore easily degenerate in this region；Phylloxanthin is protected as antioxidant and light
Effect, can promote the regeneration of rhodopsin in retina cell (Rhodopsin), can prevent laser high myopia and detachment of retina,
And vision, protection vision can be promoted.Alleviate asthenopia symptom: (blurred vision, eye dry and astringent, ophthalmic bloated, ophthalmalgia, photophobia etc.)；High yellow
Speckle pigment density, protects macula lutea, promotes that macula lutea is grown；Prevention degeneration of macula and retinitis pigmentosa；Reduce glass-film wart
Produce, the generation of prevention AMD.
Haematocoocus Pluvialls extract astaxanthin (astaxanthin), has another name called astaxanthin, Astaxanthin, is a kind Hu
Radix Raphani element, is also the highest level product of carotenogenesis.Natural astaxanthin (natural 3,4,3',4'-tetraketo-.beta.-carotene) is the strongest sky
So one of antioxidant, the oxygen-derived free radicals in effective scavenger cell, strengthen cell regeneration ability, maintain organism balance and minimizing to decline
The accumulation of old cell, protection cell and DNA are healthy from inside to outside, thus protect skin health, promotion hair growth, defying age,
Alleviate exercise fatigue, invigorate.Since two thousand eight, domestic and international numerous studies confirm that astaxanthin has stronger antioxidation and lives
Property, improving immunity, prophylaxis of tumours, cardiovascular disease, diabetes, improving the chronic diseases such as vision develops, and delays
The aspects such as aging have positive facilitation.Natural astaxanthin antioxidant activity exceedes existing antioxidant.It is removed certainly
It it is 6000 times of vitamin C efficacy by the ability of base；It it is 1000 times of vitamin E；It it is 800 times of coenzyme Q10；It it is nitric oxide
1800 times；It it is 3100 times of natto；It it is 700 times of anthocyanidin；It it is 100 times of beta-carotene effect；Be lycopene (kind
Lycopene) 10 times of effect；It it is 200 times of carotol (phylloxanthin) effect；It it is teapolyphenols (tea polyphenols) effect
320 times.Only algae and yeast and antibacterial etc. can produce astaxanthin, and more high animal can not be converted to this chemistry knot
Structure.Natural astaxanthin also has a clear and definite feature, and it is uniquely can be by a Carotenoids of blood brain barrier.
Selenium is the trace element of needed by human, and organic selenium typically exists with Selenomethionine form, follows Methionine metabolism way
Footpath metabolism, participates in the synthesis of albumen, easily stores in tissue, absorbs；Can be immediately used by the body rapidly after being absorbed by the body, have
Effect improves blood in human body in selenium situation.Old epidemiological study finds, the content of long lived elder blood selenium is higher than general old man, Central China
Engineering college observes hundreds of example old man's blood selenium and exceeds 3-6 times than healthy person.Organic selenium can remove interior free yl, protects cell membrane,
Enhancing human body immunity power, can make the symptoms such as the depression relevant with aging, immunity degradation, cataract, insomnia, dizziness, arthralgia
Be improved significantly, may also suppress and reduce the appearance of senile plaque.100 microgram vegetable active selenium can directly act on virus, presses down
The duplication in vivo of system virus, and the reparation of cell can be participated in, prevent multiple viral disease.(such as hepatitis B, carditis etc.) selenium energy
Neutralize or convert the material of free radical, antioxidation, thus dispel the infringement of radical pair human body, have the effect of slow down aging.Selenium
There is the effect identical with insulin, islets of langerhans can be independent of and usually regulate internal sugar part, can delay, alleviate, prevent glycosuria
The generation of sick complication.
Medicinal silicon dioxide is used as the novel adjuvant of one of preparation, is a kind of high-purity, mobility well white powder
End, is fabulous flow improver additive in tablet manufacturing process, can significantly improve mobility of particle, improves bulk density, makes
The tablet hardness prepared increases, and disintegration shortens, thus improves drug-eluting speed.
Visible, the section such as above-mentioned nutritional preparation Haematocoocus Pluvialls, Semen Vitis viniferae, green tea powder, lycopene, phylloxanthin, organic selenium
Formula is refined to be formed.It is ideally by antioxygens such as astaxanthin, procyanidin, tea polyphenols, lycopene, phylloxanthin, organic seleniums
Change trophic factors to organically blend, act on different sites, and collaborative enhancing antioxidation mutually at human body, block freedom
Base, effectively stops generation and the development of chronic disease, and, for the cell of corrosion, it may have certain repair,
And then make disease be able to the transformation of the direction of rehabilitation.
Nutritional preparation of the present invention is carried out clinical research
1. method
(1) experimenter selects: select the age 30-60 year, physical condition is good, without obvious brain, the heart, liver, lung, kidney
Etc. disease, without Long-term taking medicine history, volunteer the tested crowd ensureing to coordinate as inclusive criteria.Exclusion standard: gestation or age of sucking
Women；It is associated with serious disease patient；Take the article relevant with tested function in a short time, have influence on the judgement person to result；
Do not meet inclusive criteria, do not take given the test agent by regulation, it is impossible to judge that effect or data not umbra rings effect or safety is sentenced
Disconnected person.
(2) packet: 100 example experimenters, by LPO (MDA), superoxide dismutase (SOD), gluathione
Peptide peroxidase (GSH-Px) level is randomly divided into test group 50 example and matched group 50 example, considers to affect the master of result as far as possible
Want factor such as age, sex, Diet lifestyle etc., carry out harmonious inspection, with the comparability between guarantee group.
(3) medication: test group takes nutritional preparation embodiment 1 product of the present invention, once a day, each 1.6g, continuously
Take 6 months.Matched group takes placebo (starch), and dosage is identical with test group.Original living habit is not changed during test,
Normal diet.
2. experimental result
Before and after viewing test, change and the MDA of MDA decline percentage rate, the change of SOD and SOD and rise high percent, GSH-Px
Change and GSH-Px rise high percent, and every efficacy measures situation see table 1.
Before and after table 1 test, the change of MDA, SOD and GSH-Px is compared
Note: compare with before testaP < 0.01, compares with matched group,bp<0.01
From table, after test test group MDA with test before and with matched group comparing difference all have pole significance (P <
0.01)；SOD comparing difference front with experiment has pole significance (P < 0.01)
GSH-Px and matched group comparing difference have pole significance (P < 0.01).Prove that nutritional preparation of the present invention has antioxidation
Effect.
Claims (6)
1. an antioxidative nutritional preparation, it is characterised in that by hydroxyl isomaltulose, Semen Vitis viniferae extract, green tea extract,
Lycopene, phylloxanthin, Haematocoocus Pluvialls extract, organic selenium, microcrystalline Cellulose, silicon dioxide, magnesium stearate, edible essence
Composition, by weight: hydroxyl isomaltulose 20～50 parts, Semen Vitis viniferae extract 1～20 parts, green tea extract 1～15 parts, Fructus Lycopersici esculenti
Red pigment 0.1～2 parts, phylloxanthin 0.1～2 parts, Haematocoocus Pluvialls extract 1～10 parts, organic selenium 0.1～8 parts, microcrystalline Cellulose
1～30 part, silica 1～10 parts, magnesium stearate 0.01～0.1 part, edible essence 0.1～1 part.
2. the preparation method of an antioxidation nutritional preparation, it is characterised in that comprise the steps:
(1) weigh with the most mixed: weigh hydroxyl isomaltulose 20～50 parts, Semen Vitis viniferae extract 1～20 parts, green tea by weight
Extract 1～15 parts, lycopene 0.1～2 parts, phylloxanthin 0.1～2 parts, Haematocoocus Pluvialls extract 1～10 parts, organic selenium
0.1～8 part, microcrystalline Cellulose 1～30 parts, silica 1～10 parts, mix 20～30 minutes in putting into mixer successively, mistake
60 mesh sieves；
(2) pelletize: will just mix powder and put into efficient wet granulator, and use carboxymethylcellulose sodium solution to pelletize as binding agent
Wet granular is transferred to boiling drier after oscillating granulator and is dried, and dry granule carries out granulate through Fast granulate machine；
(3) always mix: dry granule is put into mixer, add magnesium stearate 0.01～0.1 part, edible essence by equal increments method
0.1～1 part, total mixed 20～30 minutes；
(4) tabletting, coating, packaging: gained granule is carried out tabletting, coating, then packs, obtain finished product.
The preparation method of a kind of antioxidation nutritional preparation the most as claimed in claim 2, it is characterised in that described Semen Vitis viniferae extracts
Thing is prepared by following method:
(1) weigh a certain amount of Semen Vitis viniferae, after vacuum drying, pulverize with Chinese medicine grinder, be 80 mesh to fineness degree；
(2) weighing a certain amount of Semen Vitis viniferae powder, adding volumetric concentration is the ethanol solution of 70%, and feed liquid mass volume ratio is that 1:10 enters
Row extracts, and Extracting temperature is 30 DEG C, and extraction time is 3h；
(3), after extracting once, it is centrifuged 4min with 3000r/min, takes supernatant；
(4) precipitate is re-dissolved in the ethanol solution of same concentrations, again extracts with identical condition, after being centrifuged, take supernatant；
(5) supernatant of twice extraction is mixed, be dried after concentration.
The preparation method of a kind of antioxidation nutritional preparation the most as claimed in claim 2, it is characterised in that described green tea extract
Prepared by following method:
(1) weigh a certain amount of green tea, pulverize with Chinese medicine grinder, be 80 mesh to fineness degree；
(2) weighing a certain amount of green tea powder, adding volumetric concentration is the ethanol solution of 70%, and feed liquid mass volume ratio 1:15,80
Extracting in DEG C water-bath, extraction time is 4h；
(3), after extracting once, it is centrifuged 5min with 4000r/min, takes supernatant；
(4) precipitate is re-dissolved in the ethanol solution of same concentrations, again extracts with identical condition, after being centrifuged, take supernatant；
(5) supernatant of twice extraction is mixed, be dried after concentration.
The preparation method of a kind of antioxidation nutritional preparation the most as claimed in claim 2, it is characterised in that described Haematocoocus Pluvialls
Extract is prepared by following method:
(1) weighing commercially available haematococcus pluvialis powder, addition ethyl acetate is as Extraction solvent, and solid-liquid ratio is 1:40 (w/v), extracts temperature
Degree is 50 DEG C, and extraction time is 3h；
(2), after extracting once, it is centrifuged 4min with 4000r/min, takes supernatant；
(3) precipitate is re-dissolved in ethyl acetate, extracts second time with identical condition, after being centrifuged, take supernatant；
(4) supernatant of twice extraction is mixed, be dried after concentration.
The preparation method of a kind of antioxidation nutritional preparation the most as claimed in claim 2, it is characterised in that described carboxymethyl is fine
In dimension element sodium solution, sodium carboxymethyl cellulose, dehydrated alcohol, the ratio of water are 1:20:10, described carboxymethylcellulose sodium solution
Collocation method be first that sodium carboxymethyl cellulose is soluble in water, add dehydrated alcohol after being completely dissolved in water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610506584.9A CN106109737A (en) | 2016-06-29 | 2016-06-29 | A kind of antioxidative nutritional preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610506584.9A CN106109737A (en) | 2016-06-29 | 2016-06-29 | A kind of antioxidative nutritional preparation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106109737A true CN106109737A (en) | 2016-11-16 |
Family
ID=57467683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610506584.9A Pending CN106109737A (en) | 2016-06-29 | 2016-06-29 | A kind of antioxidative nutritional preparation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106109737A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107136504A (en) * | 2017-04-11 | 2017-09-08 | 凯泽（武汉）健康管理有限公司 | A kind of oxidation resistant functional food |
| CN108042504A (en) * | 2017-12-15 | 2018-05-18 | 拜尔普兰（厦门）生物药业有限公司 | A kind of lutein tablet composition and preparation method thereof |
| CN108703373A (en) * | 2018-05-28 | 2018-10-26 | 广州智康元健康食品有限公司 | A kind of seven color nutrients |
| CN109007819A (en) * | 2018-07-25 | 2018-12-18 | 广州正广生物科技有限公司 | Anti- saccharification product of one kind and preparation method thereof |
| CN114586881A (en) * | 2021-04-21 | 2022-06-07 | 长春纳典生物技术有限公司 | Grape seed extract tablet candy and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103431401A (en) * | 2013-09-16 | 2013-12-11 | 厦门中药厂有限公司 | Antioxidant health care food and application thereof |
| CN104997774A (en) * | 2009-04-10 | 2015-10-28 | 齐海燕 | Novel anti-aging agent and method to identify them |
| CN105535624A (en) * | 2016-01-15 | 2016-05-04 | 中科和素（天津）医药科技有限公司 | Nutrition preparation for relieving cardiovascular and cerebrovascular diseases and preparation method thereof |
-
2016
- 2016-06-29 CN CN201610506584.9A patent/CN106109737A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997774A (en) * | 2009-04-10 | 2015-10-28 | 齐海燕 | Novel anti-aging agent and method to identify them |
| CN103431401A (en) * | 2013-09-16 | 2013-12-11 | 厦门中药厂有限公司 | Antioxidant health care food and application thereof |
| CN105535624A (en) * | 2016-01-15 | 2016-05-04 | 中科和素（天津）医药科技有限公司 | Nutrition preparation for relieving cardiovascular and cerebrovascular diseases and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107136504A (en) * | 2017-04-11 | 2017-09-08 | 凯泽（武汉）健康管理有限公司 | A kind of oxidation resistant functional food |
| CN108042504A (en) * | 2017-12-15 | 2018-05-18 | 拜尔普兰（厦门）生物药业有限公司 | A kind of lutein tablet composition and preparation method thereof |
| CN108703373A (en) * | 2018-05-28 | 2018-10-26 | 广州智康元健康食品有限公司 | A kind of seven color nutrients |
| CN109007819A (en) * | 2018-07-25 | 2018-12-18 | 广州正广生物科技有限公司 | Anti- saccharification product of one kind and preparation method thereof |
| CN109007819B (en) * | 2018-07-25 | 2022-08-05 | 广州正广生物科技有限公司 | Anti-saccharification product and preparation method thereof |
| CN114586881A (en) * | 2021-04-21 | 2022-06-07 | 长春纳典生物技术有限公司 | Grape seed extract tablet candy and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106109737A (en) | A kind of antioxidative nutritional preparation and preparation method thereof | |
| CN102552549B (en) | Composition for improving visual fatigue and preparation method and application thereof | |
| CN102144780A (en) | Lutein ester health care product for protecting eyesight and preparation method thereof | |
| US9889173B2 (en) | Composition for improving macular pigment density and preventing or treating age-related macular degeneration | |
| CN102225087A (en) | Xanthophyll compound preparation with powerful eye-protecting effect | |
| CN104839688A (en) | Eye care preparation and preparation method thereof | |
| CN104739921A (en) | Formula lozenge for relieving visual fatigue and preparation method thereof | |
| CN109663122A (en) | It is a kind of to provide nutrition, improvement eyesight, the composition grain electuary for preventing eye disease and preparation method thereof for macula retinae area | |
| JP2008271878A (en) | Novel food and drink | |
| CN102960520B (en) | L-arabinose health-care press candy added with cyclocarya paliurus | |
| CN111528421A (en) | Eye-protecting product containing plant exosomes and preparation method thereof | |
| CN101283806A (en) | Diet replenisher containing natural carotenol and its preparation technique | |
| CN1278737C (en) | Compound medicinal formulation with bioactivity | |
| CN110506879A (en) | A kind of solid beverage and its preparation method for alleviating visual fatigue | |
| CN105983016B (en) | A pharmaceutical composition containing silybin | |
| JP2021508433A (en) | Carob fruit composition and its preparation method and application | |
| CN100486456C (en) | Health-care food used for reliefing eyestrain, and its preparing method | |
| CN111202243A (en) | Special dietary food of soft capsule for strengthening eyesight and its preparation method | |
| KR100697184B1 (en) | A functional food for a ginseng and mulberry and banaba and the producing method therof | |
| CN103584095B (en) | Treat hypertensive health beverages and preparation method thereof | |
| JP5893438B2 (en) | Retinopathy preventive or ameliorating agent | |
| CN104432392A (en) | Heart-strengthening and aging-resisting blueberry solid particle beverage and preparation method thereof | |
| CN1785053A (en) | Health-care food for relieving-vision fatigue and its prepn. method | |
| CN112691150A (en) | Composition and preparation method and application thereof | |
| CN103404875A (en) | Complex ocean special-diet food eaten by patients with cardiovascular disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161116 |