KR100697184B1 - A functional food for a ginseng and mulberry and banaba and the producing method therof - Google Patents

A functional food for a ginseng and mulberry and banaba and the producing method therof Download PDF

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KR100697184B1
KR100697184B1 KR1020060001800A KR20060001800A KR100697184B1 KR 100697184 B1 KR100697184 B1 KR 100697184B1 KR 1020060001800 A KR1020060001800 A KR 1020060001800A KR 20060001800 A KR20060001800 A KR 20060001800A KR 100697184 B1 KR100697184 B1 KR 100697184B1
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ginseng
leaves
functional food
extract
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이광승
오원일
성미경
이상덕
박민수
이은실
김진규
조일식
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주식회사 농협고려인삼
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30Dietetic or nutritional methods, e.g. for losing weight
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Pediatric Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

A functional food for lowering glucose in blood using ginseng, mulberry leaves, and banaba leaves is provided to prevent and treat type 2 diabetes and prevent obesity by reducing concentrations of leptin and neutral fat in blood. The functional food for lowering glucose in blood using ginseng, mulberry, and banaba is manufactured by the steps of: drying and grinding a ginseng according a general method to obtain ginseng powder; putting mulberry leaves into an extraction tank, thereto adding purified water 8-10 times more than the total weight of the mulberry leaves, performing water extraction for 8-10 hours to obtain an extract, filtering the extract, concentrating the filtrate to 40-60Brix, sterilizing the concentrate, and drying the sterilized concentrate to obtain mulberry leave extract powder; putting banaba leaves into an extraction tank, thereto adding purified water 8-10 times more than the total weight of the banaba leaves, performing water extraction for 8-10 hours to obtain the extract solution, filtrating the extract solution to be concentrated to 40-60Brix, sterilizing the concentrate, and drying the sterilized concentrate to obtain banaba leave extract powder; and mixing the ginseng powder, mulberry leave extract powder, and banaba leave extract powder in a weight ratio of 1:1:1.

Description

인삼과 상엽과 바나바엽을 주재로 한 혈당강하용 기능성 식품 및 그 제조방법{A functional food for a ginseng and mulberry and banaba and the producing method therof}Technical Field [0001] The present invention relates to a functional food for reducing blood glucose and a method for producing the functional food for ginseng and mulberry,

도 1은 본 발명에 따른 실험예에서 각 실험군의 혈중 포도당 수치의 변화를 나타낸 그래프1 is a graph showing the change in blood glucose level of each test group in the experimental example according to the present invention

도 2는 본 발명에 따른 실험예에서 각 실험군의 혈중 당화 헤모글로빈 수치의 변화를 나타낸 그래프FIG. 2 is a graph showing changes in blood glycated hemoglobin levels in the experimental groups according to the present invention

도 3은 본 발명에 따른 실험예에서 각 실험군의 혈중 인슐린 수치의 변화를 나타낸 그래프FIG. 3 is a graph showing changes in blood insulin levels in the experimental groups according to the present invention

도 4는 본 발명에 따른 실험예에서 각 실험군의 혈중 렙틴의 수치를 나타낸 그래프FIG. 4 is a graph showing the levels of leptin in blood of each experimental group in the experimental example according to the present invention

도 5는 본 발명에 따른 실험예에서 각 실험군의 혈중 중성지방의 수치를 나타낸 그래프FIG. 5 is a graph showing the blood triglyceride levels in the experimental groups according to the present invention

본 발명은 인삼의 분말과 상엽추출물 및 바나바엽추출물의 분말을 혼합하여 제조된 혈당감소를 위한 식품에 관한 것으로, 더욱 상세하게는 통상의 방법으로 건조 분쇄된 인삼분말과, 추출탱크에 상엽을 넣고 상엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하고 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하고 살균처리하며 균질(均質)처리한 다음 건조하여 제조된 상엽추출물분말과, 추출탱크에 바나바엽을 넣고 바나바엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하고 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하고 살균처리하며 균질(均質)처리한 다음 건조하여 제조된 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하여 기능성 식품을 제조하고 상기 기능성 식품을 캡슐형태나 타블렛 또는 과립형태로 제조하거나, 또는 상기 기능성 식품을 음료 전체 중량에 대하여 0.1 ~ 10중량% 포함된 상태로 첨가하여 음료형태로 제조하는 것을 특징으로 하는 인삼과 상엽과 바나바엽을 주재로 한 혈당강하용 기능성 식품 및 그 제조방법에 관한 것이다.The present invention relates to a food for reducing blood glucose, which is prepared by mixing powder of ginseng powder, leaf extract of upper leaf and powder of banaba leaf extract, more specifically, 8 to 10 times of purified water is added to the total weight of the upper leaves and the mixture is extracted with water at 80 to 90 ° C for 8 to 10 hours. The extract is filtered, concentrated under reduced pressure at 45 to 60 ° C to 40 to 60 Brix, sterilized, And 8-10 times of purified water was added to the total weight of the barnacle leaf. The extract was extracted with water at 80 to 90 ° C for 8 to 10 hours, and then the extract was filtered The mixture was concentrated to a concentration of 40 to 60 Brix at 45 to 60 ° C, sterilized, homogenized, and then dried to prepare a functional food at a weight ratio of 1: 1: 1 Characterized in that the functional food is prepared in the form of a capsule, a tablet or a granule, or the functional food is added in a form containing 0.1 to 10% by weight based on the total weight of the beverage to form a beverage. The present invention relates to a functional food for hypoglycemia based on leaves and a method for producing the same.

일반적으로 당뇨병은 인슐린 작용장애와 고혈당으로부터 초래되는 심각한 대사성 장애로서, 당뇨병은 그 자체가 큰 질환이라기 보다는 장기간 이 질환에 걸려 있음으로 해서 발병하는 합병증, 예를들어 당뇨병성 신경병증(neuropathy), 망막병증(retinopathy), 백내장(cataract), 신증(nephropathy) 등으로 인해 환자들이 정 상적인 삶을 영위할 수 없을 뿐 아니라 치명적인 결과까지 초래할 수 있기 때문에 사회적으로 큰 문제가 되는 것이다. 케토산증(ketoacidosis)를 동반한 고혈당증의 경우에는 심한 전해질 이상과 뇌부종, 혈관허탈 등의 문제를 야기시키고, 만성적으로 고혈당이 지속되면 눈, 신장, 심장혈관을 포함한 많은 장기의 손상이 오는 장기적 합병증이 발생하게 되며, 고혈당의 과교정으로 저혈당이 생기면 경련, 의식소실, 사망 등에 이를 수 있게 된다. In general, diabetes is a serious metabolic disorder resulting from insulin dysfunction and hyperglycemia. Diabetes is not a large disease in itself, but complications that arise as a result of long-term illnesses such as diabetic neuropathy, It is a social problem because retinopathy, cataract, and nephropathy can not only lead to normal life, but also can lead to fatal outcomes. Hyperglycemia with ketoacidosis leads to severe electrolyte abnormalities, brain edema, vascular collapse, and chronic long-term complications such as eye, kidney, and cardiovascular damage. And hypoglycemia resulting from overcorrection of hyperglycemia can lead to seizures, loss of consciousness, and death.

이러한 당뇨병은 그 발병원인 및 증상의 치료방법에 따라 크게 제 1형 당뇨병인 인슐린 의존형 당뇨병(Insulin dependent diabetes mellitus, IDDM)과 제 2형당뇨병인 인슐린 비의존형 당뇨병(Non- insulin dependent diabetes mellitus, NIDDM)으로 분류할 수 있으며, 우리나라의 경우 당뇨병 환자의 95% 이상이 인슐린 비의존형 당뇨병(NIDDM) 환자이다. These diabetes mellitus is largely classified into type 1 diabetes insulin dependent diabetes mellitus (IDDM) and type 2 diabetes mellitus non-insulin dependent diabetes mellitus (NIDDM) . In Korea, more than 95% of diabetic patients are NIDDM (non-insulin dependent diabetes mellitus) patients.

당뇨병 환자의 대부분을 차지하고 있는 제 2형 당뇨병인 인슐린 비의존형 환자들은 질병의 치료를 위해 식이요법과 함께 경구용 혈당강하제를 선별적으로 사용하고 있다. 미국의 경우 설포닐우레아 계통의 약물이 유일한 혈당강하제로 사용되고 있고, 유럽 및 아시아 지역에서는 비구아니드 계통의 약물도 함께 사용되고 있다. 바람직한 혈당강하제는 작용이 신속히 발현되어 식후의 과도한 혈당상승을 막고 그후에는 짧은 시간내에 그 효과가 소실되어 저혈당을 일으키지 않아야 하며, 또한 당뇨병에 수반되는 대사이상증상을 호전시킬 수 있어야 하나 현재 사용되고 있는 설포닐우레아 계통이나 비구아니드 계통의 약물들은 이런 점에서 완전하게 바람직하지는 못한 것이어서, 이러한 약물 대신 거부감없이 쉽게 복용하기 쉬우며 인 체에 부작용이 없고 혈당강하 효과가 큰 건강 기능성 식품개발의 필요성이 크게 증대되고 있는 실정이다. Non - insulin dependent type 2 diabetes, which accounts for the majority of diabetic patients, uses oral hypoglycemic agents in combination with dietary therapy to treat disease. In the United States, sulfonylurea drugs are the only antihyperglycemic agents used, and in Europe and Asia, the drugs are also used. A desirable hypoglycemic agent should not cause hypoglycemia due to the rapid expression of the action and prevent the excessive increase in blood glucose after the meal and then disappear within a short period of time so that the hypoglycemia may not occur and the metabolic syndrome accompanying diabetes should be improved. Phonylurea and buguanide drugs are not entirely desirable in this respect. Instead of these drugs, it is easy to take them easily without any discomfort, and there is no need for side effects on human body and the need for development of health functional foods with high blood glucose lowering effect It is a fact that it is increasing.

종래에는 상기와 같은 건강 기능성 식품으로서 대한민국 등록특허공보 등록번호 제 10-048551호에서는 「 뽕잎을 시루에서 60℃온도의 수증기로 30분동안 찌고 24시간동안 건조시킨 후 고운 가루로 만드는 뽕잎건조 및 제분공정과; 미역 및 다시마를 현미식초에 12시간동안 침전하여 미역 및 다시마의 염분농도가 1중량% 미만이 되도록 탈염하고, 건조후 고운가루로 만드는 미역 및 다시마의 건조 및 제분공정과; 검은콩을 현미식초에 담구어 7일동안 발효시킨 후 건조하여 고운 가루로 만드는 초콩 발효 및 제분공정과; 상기의 공정을 거친 뽕잎가루 30중량%, 미역가루 34중량%, 다시마가루 20중량% 및 초콩가루 12중량%와 현미식초 2.5중량%, 맥아가루 1중량% 및 심황가루 0.5중량%를 혼합하는 혼합공정과; 혼합공정을 거쳐 혼합된 재료를 일정크기의 알약으로 빚어 60℃의 온도에서 12시간동안 건조하고, 다시 90 ~ 100℃의 온도에서 6시간동안 건조시키는 제환 및 건조공정으로 이루어지는 것을 특징으로 하는 뽕잎을 이용한 건강식품 제조방법 」이 개시되었으나, 상기 선등록 특허에서는 당뇨병의 예방 및 치료를 위하여 사용된 혈당강하 재료로서는 뽕잎(상엽)하나만을 사용하여 혈당강하를 위한 치료효율이 낮게 나타나는 문제점이 있었다. Conventionally, as a health functional food as described above, Korean Registration Patent Publication No. 10-048551 discloses " mulberry leaves are dried in steam at a temperature of 60 < 0 > C for 30 minutes and then dried for 24 hours to prepare mulberry leaves A process; Seaweed and kelp are precipitated in brown rice vinegar for 12 hours to desalinate so that the salt concentration of the seaweed and kelp is less than 1% by weight, followed by drying and milling of seaweed and kelp, which is dried and formed into fine powder; Black soybeans were dipped in brown rice vinegar, fermented for 7 days, and then dried to produce a fine powder; A mixture of 30% by weight of mulberry leaf powder, 34% by weight of seaweed powder, 20% by weight of kelp powder and 12% by weight of superfine flour, 2.5% by weight of brown rice vinegar, 1% by weight of malt flour and 0.5% A process; Characterized by comprising a pouring and drying step in which the mixed material is mixed with a pellet of a predetermined size and dried at a temperature of 60 DEG C for 12 hours and further dried at a temperature of 90 to 100 DEG C for 6 hours However, in the above-mentioned prior-art patent, only one mulberry leaf (upper leaf) is used as a hypoglycemic material used for the prevention and treatment of diabetes, and the treatment efficiency for blood glucose lowering is low.

본 발명은 상기와 같은 문제점들을 개선하기 위한 것으로 기존의 양약 대신 천연식물재료로서 인삼분말과 상엽추출물분말과 바나바엽추출물분말을 일정비율로 혼합하여 제조된 조성물을 건강 보조식품으로 취식하도록 함으로써 인체에 거부감이나 부작용이 없어 누구나 쉽게 복용할 수 있으며, 높은 혈당강하 효과와 함께 혈중 랩틴(leptin)의 농도와 중성지방의 농도를 크게 낮추어 주어 당뇨병의 예방과 치료뿐 아니라 비만예방 및 심장순환기계통의 질환 예방에 효과가 큰 건강 기능성 식품을 제공하는 것에 그 목적이 있다. The present invention has been made to solve the above problems, and it is an object of the present invention to provide a composition prepared by mixing a ginseng powder, a leaf extract, It can be easily taken by anyone because it has no rejection or side effects. It can be used easily by anyone. It can lower blood leptin concentration and triglyceride concentration with high blood sugar lowering effect and prevent diabetes and prevent diabetes as well as prevention of obesity and cardiovascular diseases The present invention has been made in view of the above problems.

이러한 목적을 달성하기 위하여 To achieve this goal,

통상의 방법으로 건조 분쇄된 인삼분말과, 추출탱크에 상엽을 넣고 상엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하고 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하고 살균처리하며 균질(均質)처리한 다음 건조하여 제조된 상엽추출물분말과, 추출탱크에 바나바엽을 넣고 바나바엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하고 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하고 살균처리하며 균질(均質)처리한 다음 건조하여 제조된 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하여 기능성 식품을 제조하고 상기 기능성 식품을 캡슐형태나 타블렛 또는 과립형태로 제조하거나, 또는 상기 기능성 식품을 음료 전체 중량에 대하여 0.1 ~ 10중량% 포함된 상태로 첨가하여 음료형태로 제조하는 것에 본 발명의 특징이 있다. The dried ginseng powder and the upper leaves are put into the extraction tank and 8 ~ 10 times of the purified water is added to the total weight of the upper leaves. The ginseng powder is extracted with water at 80 ~ 90 ° C for 8 ~ 10 hours, The extracts were prepared by homogenizing and drying the concentrate at a reduced pressure of 40 to 60 Brix at a temperature of 60 to 60 ° C. and then drying the extract. Then, the extract was poured into the extraction tank at a rate of 8 to 10 times as much as the total weight of the leaf of the barnaby And extracted with water at 80 to 90 ° C for 8 to 10 hours. The extract was filtered, concentrated under reduced pressure at 45 to 60 ° C, sterilized at 45 to 60 ° C, homogenized, and then dried. : 1: 1 by weight to prepare a functional food and preparing the functional food in the form of a capsule, tablet or granule, or 0.1 to 10% by weight of the functional food with respect to the total weight of the beverage There is a feature of the invention that by adding a condition for producing a beverage form.

본 발명에 따른 인삼, 상엽, 바나바엽을 주재로 한 혈당강하용 기능성 식품 은 통상의 방법으로 건조 분쇄된 인삼분말과, 추출탱크에 상엽을 넣고 상엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하고 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하고 살균처리하며 균질(均質)처리한 다음 건조하여 제조된 상엽추출물분말과, 추출탱크에 바나바엽을 넣고 바나바엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하고 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하고 살균처리하며 균질(均質)처리한 다음 건조하여 제조된 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하여 제조된다.According to the present invention, the functional foods for reducing blood glucose based on ginseng, upper leaves and barnaby leaves are prepared by dry-pulverizing the ginseng powder and the upper leaves in an extraction tank and adding 8 to 10 times of purified water to the total weight of the upper leaves And extracted with water at 80 to 90 ° C for 8 to 10 hours. The extract is filtered, concentrated under reduced pressure at 45 to 60 ° C. at 40 to 60 Brix, sterilized, homogenized, and dried. 8-10 times of purified water was added to the total weight of the barnaby leaf and the mixture was extracted with water at 80 to 90 ° C for 8 to 10 hours. The extract was filtered, concentrated under reduced pressure at 40 to 60 Brix at 45 to 60 ° C Sterilized and homogenized, and then dried to prepare a mixture of the powder of the extract of Liliaceae leaf extract at a weight ratio of 1: 1: 1.

인삼은 예로부터 한방의학에서 수천년 동안의 경험에 의하여 그 약효가 특출한 것으로 인정받아 왔고 신농본초경(神農本草經)이나 본초강목(本草綱目) 등의 고서에서는 주로 오장을 보하고 정신을 안정시키며 경계(驚悸)를 멈추게 하고 눈을 밝게 하며 머리를 지혜롭게 하고 오랫동안 복용하면 수명(壽命)을 연장하게 하는 효능이 있는 것으로 알려져 왔으며, 현대에서는 간기능회복, 항암면역 효과, 항스트레스, 피로회복, 당질·지질·단백질대사 조절 등의 효능이 있고, 특히 당뇨병에 유효한 혈당 강하 작용과 일반 자각증상 개선 효과 등이 있는데, 인삼의 혈당 강하 작용은 매우 효과적이며 합성당뇨병 치료약과 같이 지나치게 혈당 당뇨치를 떨어뜨리는 위험이 없기 때문에 당뇨병 치료제와 함께 복용하면서 보조 치료제로 사용하여도 좋은 효능이 있는 것으로 알려져 있다. Ginseng has been known for its medicinal properties for thousands of years in ancient oriental medicine and has been widely recognized for its efficacy in ancient Chinese medicine such as Shinanbongkoree or Bonchu Gangmok, It has been known that it has the effect of stopping the asthma, brightening the eyes, wisdom of the hair, and prolonging the life span by taking it for a long time. In the modern age, it is known that the recovery of liver function, anti-cancer immunity effect, And lipid / protein metabolism control. Especially, there are effective blood sugar lowering effect and general awareness improvement effect on diabetes. Ginseng's hypoglycemic effect is very effective, and there is a risk of lowering blood sugar diabetes Because it is not available, it can be used as an adjunctive treatment while taking it with diabetes treatment. There are known.

본 발명에서는 상기와 같은 효능을 지닌 인삼을 선별하여 통상의 방법으로 건조 분쇄한 다음 100mesh 표준체를 사용하여 입도조절된 인삼분말을 사용한다.In the present invention, ginseng having the above-mentioned effect is selected, dried and pulverized by a conventional method, and then ginseng powder whose particle size is controlled using a 100 mesh standard is used.

또한, 상기 인삼분말은 상위개념으로 기재된 것으로 인삼에 속하는 백삼이나 피부백삼 또는 홍삼 등을 건조 분말화한 백삼분말, 피부백삼분말, 홍삼분말 등을 선택하여 사용할 수 있으며, 본 발명에서는 80 ~ 100mesh로 분쇄된 홍삼분말을 선택하여 실시예 및 실험예에 사용하였다.In addition, the ginseng powder may be selected from white ginseng powder, white ginseng powder, red ginseng powder, red ginseng powder, and the like, which are ginseng powder, white ginseng or skin white ginseng or dried ginseng powder, The pulverized red ginseng powder was selected and used in Examples and Experimental Examples.

상엽은 뽕나무(Morus alba L.)의 잎으로서, 그 효능에 대하여 본초강목(本草綱目)에서는 각기병과 몸이 붓는 증세, 소갈증(현대의 당뇨병), 풍, 멍들고 풍으로 아픈 곳, 뱀과 벌레에 물린데, 밤에 땀이 나는 증세, 정강이가 오그라져 펴지지 않는 증세, 탈항, 종기나 등창, 못에 찔린 상처, 데인 상처, 손발이 저리고 감각이 없는 증세 등에 좋은 것으로 기재되어 있으며, 특히 최근 연구에 의하면 상엽에는 플라본류(flavones), 스테로이드류(steroids), 트리테르펜류(triterpenes), 아미노산(amino acids), 비타민(vitamin)류와 다량의 미네랄과 질소함유설탕(N-containing sugers) 등의 존재가 밝혀졌으며, 스트랩토조토신(streptozotocin)을 투여하여 인위적으로 당뇨를 유발시킨 실험용 쥐에 상엽 추출물을 투여하거나 식이로 섭취시켰을 때 혈당강하 효과와 이당류 분해효소의 활성증가와 지질대사의 개선 등이 과학적으로 입증되었다. The leaf of Morus alba L. is the leaf of Mulberry (Morus alba L.), and its efficacy is on the main stem of Gangbok (草草目), the symptoms of swelling of the legs and body, the symptoms of petechiae (modern diabetes), wind, bruises and sickness, It is said that it is good for bite, sweating at night, symptom of shrinking shin, exfoliation, swelling of boil, stab wound, dain wound, limb and numbness, The presence of flavones, steroids, triterpenes, amino acids, vitamins, large amounts of minerals and N-containing sugars in the upper leaves, , And when streptozotocin was administered to rats to induce diabetes mellitus, the effects of hypoglycemic effect and disaccharide degradation enzyme activity were increased The improvement in lipid metabolism have been scientifically proven.

본 발명에서는 상기와 같은 효능을 지닌 상엽을 선별하여 추출탱크에 넣고 상엽의 전체 중량에 대하여 80 ~ 90℃에서 8 ~ 10배의 정제수를 가하여 8 ~ 10시간 동안 물추출한 후 추출액을 저장조에 넣고 마이크로 필터로 여과한 다음 상기 여과 액을 농축탱크로 이송하여 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하고 농축액을 60 ~ 70℃에서 20 ~ 40분간 살균처리한 다음 균질기(homogenizer)로 균질(均質)하게 혼합하고 분무건조기에서 열풍으로 80 ~ 90℃에서 건조시킨 후 냉각시키거나 진공건조방식으로 건조하여 진동체에서 80 ~ 100mesh로 입도조절한 상엽추출물분말을 사용하게 된다. In the present invention, the upper leaves having the above-mentioned effects are selected and placed in an extraction tank. 8-10 times of purified water is added at 80 ~ 90 ° C based on the total weight of the upper leaves, and water is extracted for 8 ~ 10 hours. After filtration, the filtrate was transferred to a concentration tank and concentrated under reduced pressure at 45 to 60 ° C. at 40 to 60 Brix. The concentrate was sterilized at 60 to 70 ° C. for 20 to 40 minutes and homogenized with a homogenizer ), And dried in a spray drier at 80 to 90 ° C with hot air, followed by cooling or drying in a vacuum drying method, thereby using the leaf extract powder whose particle size is adjusted to 80 to 100 mesh in the vibrating body.

바나바엽은 열대나 아열대지방에서 자생하고 있는 다년생 상록수인 바나바(Lagerstroemmia speciosa Pers.)의 잎으로, 주요성분으로 콜로소린산(Corosolic Acid), 아연, 철분, 칼슘, 마그네슘 등이 포함되어 있으며, 활성성분 중 콜로소린산(Corosolic Acid)은 잎 마다 차이는 있지만 평균적으로 0.1 ~ 0.35% 정도가 들어 있는데, 최근 연구에서는 상기 콜로소린산이 인슐린과 동일하게 글루코스를 세포내에 신속하게 흡수시키는 것 즉, 포도당 운반체(Glucose Transporter)를 활성화시키는 기능을 하여 혈당 강하작용 및 정상혈당에 영향을 미치지 않으면서 혈당치의 재상승을 억제하는 작용 등을 하는 것으로 입증되었다.Baraba leaf is a leaf of Lagerstroemmia speciosa Pers., A perennial evergreen tree native to tropical and subtropical regions. Its main components are corosolic acid, zinc, iron, calcium and magnesium. Corosolic acid among the components varies from leaf to leaf in an average of 0.1 to 0.35%. In recent studies, it was shown that the coloso- rinic acid rapidly absorbs glucose into cells in the same manner as insulin, (Glucose Transporter) to function to lower blood glucose levels and normal blood glucose without affecting the re-elevation of blood glucose levels and has been proven to work.

본 발명에서는 상기와 같은 효능을 지닌 바나바엽을 선별하여 추출탱크에 넣고 바나바엽의 전체 중량에 대하여 8 ~ 10배의 정제수를 가하여 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 저장조에 넣고 마이크로 필터로 여과한 다음 상기 여과액을 농축탱크로 이송하여 45 ~ 60℃에서 40 ~ 60Brix로 농축하고 농축액을 60 ~ 70℃에서 20 ~ 40분간 살균처리한 다음 균질기(homogenizer)로 균질(均質)하게 혼합하고 분무건조기에서 열풍으로 80 ~ 90℃에서 건조시킨 후 냉각시키거나 진 공건조방식으로 건조하여 진동체에서 80 ~ 100mesh로 입도조절한 바나바엽추출물분말을 사용하게 된다. In the present invention, the barbaba leaf having the above-mentioned effect is selected and put into an extraction tank. 8-10 times of purified water is added to the total weight of the barbaba leaf, and water is extracted at 80 ~ 90 ° C for 8 ~ 10 hours. And filtered through a microfilter. The filtrate was transferred to a concentration tank, concentrated at 40 to 60 Brix at 45 to 60 ° C, sterilized at 60 to 70 ° C for 20 to 40 minutes, homogenized with a homogenizer And then dried in a spray drier at 80 to 90 ° C. in a hot air dryer or in a vacuum drying method to use a powder of a banaba leaf extract whose particle size is adjusted to 80 to 100 meshes in a vibrating body.

상기와 같이 제조된 인삼분말과 상엽추출물분말과 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하여 기능성 식품을 제조하고 상기 기능성 식품을 캡슐형태나 타블렛 또는 과립형태로 제조하여 사용하거나, 또는 상기 기능성 식품을 음료 전체 중량에 대하여 0.1 ~ 10중량% 포함된 상태로 첨가하여 음료형태로 제조하여 사용할 수 있다.The ginseng powder, the upper leaf extract powder and the barbara leaf extract powder prepared as described above are mixed at a weight ratio of 1: 1: 1 to prepare a functional food, and the functional food is prepared in the form of a capsule, a tablet or a granule, The functional food may be added to the beverage in an amount of 0.1 to 10% by weight based on the total weight of the beverage.

또한, 상기 기능성 식품에 대하여 간기능강화와 혈당강하에 효능이 있는 누에분말 0.5 ~ 2중량부와, 식용촉진 및 간보호에 효능이 있는 비타민 B1 0.5 ~ 2중량부와, 발육촉진 및 에너지 대사 촉진에 효능이 있는 비타민 B2 0.5 ~ 2중량부와, 콜레스테롤 및 혈당 강하에 효능이 있는 실크아미노산 0.5 ~ 2중량부를 첨가하여 통상의 방법으로 캡슐형태나 타블렛 또는 과립형태로 제조하거나, 음료 전체 중량에 대하여 0.1 ~ 10중량% 포함된 상태로 첨가하여 통상의 방법으로 음료형태로 제조하여 사용할 수 있다.0.5 to 2 parts by weight of silkworm powder having an effect on liver function and blood sugar lowering effect on the functional food, 0.5 to 2 parts by weight of vitamin B 1 effective for promoting food promotion and liver protection, 0.5 to 2 parts by weight of vitamin B 2 which is effective for promotion and 0.5 to 2 parts by weight of silk amino acid which is effective for decreasing cholesterol and hypoglycemia may be added to prepare capsules, tablets or granules by a conventional method, 0.1 to 10% by weight based on the total weight of the composition.

< 실시예 ><Examples>

선별된 홍삼을 통상의 방법으로 건조 분쇄하고 100mesh 표준체에 걸러 입도조절된 홍삼분말과, 선별된 상엽 100kg을 추출탱크에 넣고 상엽의 전체 중량에 대하여 9배의 정제수를 가하여 85℃에서 9시간 동안 물추출한 후 추출액을 저장조에 넣고 마이크로 필터로 여과한 다음 상기 여과액을 농축탱크로 이송하여 55℃에서 50Brix로 감압농축하고 농축액을 65℃에서 30분간 살균처리한 다음 균질기(homogenizer)로 균질하게 혼합하고 분무건조기에서 열풍으로 85℃에서 건조시킨 후 냉각시키고 100mesh 진동체로 걸러 입도조절된 상엽추출물분말과, 선별된 바나바엽 100kg을 추출탱크에 넣고 상엽의 전체 중량에 대하여 9배의 정제수를 가하여 85℃에서 9시간 동안 물추출한 후 추출액을 저장조에 넣고 마이크로 필터로 여과한 다음 상기 여과액을 농축탱크로 이송하여 55℃에서 50Brix로 감압농축하고 농축액을 65℃에서 30분간 살균처리한 다음 균질기(homogenizer)로 균질(均質)하게 혼합하고 분무건조기에서 열풍으로 85℃에서 건조시킨 후 냉각시키고 100mesh 진동체로 걸러 입도조절된 바나바엽추출물분말을 각각 1 : 1 : 1 의 중량비로 혼합하여 기능성 식품을 제조하였다.The selected red ginseng was dried and pulverized by a conventional method, and red ginseng powder whose particle size was controlled by a 100 mesh standard and 100 kg of the selected top leaves were put into an extraction tank, and 9 times of purified water was added to the total weight of the top leaves. After extracting, the extract was put in a storage tank and filtered with a microfilter. The filtrate was transferred to a concentration tank, and the filtrate was concentrated under reduced pressure at 55 ° C to 50 Brix. The concentrate was sterilized at 65 ° C for 30 minutes and homogenized with a homogenizer Dried in a spray drier at 85 ° C, cooled, filtered with a 100 mesh vibrator, and 100 kg of selected leaf extracts were placed in an extraction tank, and 9 times of purified water was added to the total weight of the leaf, After the extraction of water for 9 hours, the extract solution was put into a storage tank and filtered with a microfilter. Then, the filtrate was transferred to a concentration tank to obtain 55 And concentrated to 50 Brix. The concentrate was sterilized at 65 ° C for 30 minutes, homogenized with a homogenizer, dried in hot air at 85 ° C in a spray drier, cooled, Barnaf leaf extract powder were mixed at a weight ratio of 1: 1: 1, respectively, to prepare a functional food.

< 실험예 ><Experimental Example>

인위적으로 유전적변이를 일으켜 렙틴(leptin)의 피드백 신호전달을 차단하여 성장함에 따라 체중과다와 함께 제 2형 당뇨병이 유발되도록 한 실험용 쥐들(C57BL/KsJ db/db mouse(♂))(4주령)을 상온에서 12시간씩 낮조건과 밤조건을 반복유지하며 자유롭게 식이와 물을 섭취할 수 있도록 준비하고, 상기 실험용 쥐들을 각 실험군 당 10마리씩 무작위로 배정하되 제 1군을 대조군, 제 2군을 상엽군, 제 3군을 홍삼군, 제 4군을 바나바엽군, 제 5군을 혼합군으로 각각 편성하고, 상기 상엽군에는 실시예에서의 중간생성물인 상엽추출물분말만을 전체 식이에 0.5중량% 혼합하여 실험용 식이로 공급하였으며, 상기 홍삼군에는 실시예에서의 중간생성물인 홍삼분말만을 전체 식이에 0.5중량% 혼합하여 실험용 식이로 공급하였고, 상기 바나바엽군에는 실시예에서의 중간생성물인 바나바엽추출물분말만을 전체 식이에 0.5중량% 혼합하여 실험용 식이로 공급하였으며, 상기 혼합군에는 실시예의 최종생성물인 기능성 식품을 전체 식이에 0.5중량% 혼합하여 실험용 식이로 공급하였고, 각 실험군에 공급되는 구체적인 실험용 식이의 구성은 아래 < 표 1 > 과 같이 구성하여 매일 동일한 양을 공급하면서 12주간 사육하였다.(C57BL / KsJ db / db mouse (♂)), which induced type 2 diabetes mellitus with overgrowth as a result of artificial genetic mutation and blocked feedback signaling of leptin ) Were allowed to freely eat diets and water at room temperature for 12 hours while repeating day and night conditions. The experimental rats were randomly assigned to 10 rats in each experimental group. The first group was divided into the control group, the second group , The third group was classified into the red ginseng group, the fourth group was classified into the group of the banaba leaf group, and the fifth group was classified into the mixed group. In the upper leaves group, only the middle leaf extract powder of the examples was added to the total diet in an amount of 0.5 wt% In the red ginseng group, only the red ginseng powder as an intermediate product in the examples was mixed with 0.5% by weight of the whole diets, and the mixture was supplied to the experimental diets. And 0.5% by weight of the extract of Barnabas leaf extract was added to the whole diet, and the mixture was supplied to the experimental diet. In the mixed group, 0.5% by weight of the functional food as the final product of the examples was mixed into the whole diet and fed to the experimental diet. The composition of the experimental diets was as shown in Table 1 below and was fed for 12 weeks while supplying the same amount every day.

< 표 1 > 각 실험군에 공급되는 실험용 식이의 구성성분 <Table 1> Components of experimental diets fed to each experimental group

대조군Control group 상엽군Sangyeop 홍삼군Red ginseng 바나바엽군Barnacles 혼합군Mixed group Casein Casein 2020 19.9519.95 19.9519.95 19.9519.95 19.9519.95 Starch Starch 1515 14.6714.67 14.6714.67 14.6714.67 14.6714.67 Sucrose Sucrose 5050 49.8949.89 49.8949.89 49.8949.89 49.8949.89 Corn oil Corn oil 55 4.994.99 4.994.99 4.994.99 4.994.99 Cellulose Cellulose 55 55 55 55 55 DL-Methionine DL-Methionine 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 Mineral Mix Mineral Mix 3.53.5 3.53.5 3.53.5 3.53.5 3.53.5 Vitamin Mix Vitamin Mix 1One 1One 1One 1One 1One Choline Chloride Choline Chloride 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 Red Ginseng Red Ginseng -- -- 0.50.5 -- 0.5/30.5 / 3 Mulberry Mulberry -- 0.50.5 -- -- 0.5/30.5 / 3 Banaba Banaba -- -- -- 0.50.5 0.5/30.5 / 3 Total(중량%) Total (% by weight) 100중량%100 wt% 100중량%100 wt% 100중량%100 wt% 100중량%100 wt% 100중량%100 wt%

① 혈중 포도당 측정① blood glucose measurement

실험기간 중 0, 2, 4, 6, 8, 10, 12주째에 각각 실험용 쥐들을 7시간 절식시킨 후 공복상태에서 실험용 쥐들의 꼬리 정맥에서 채혈하고 혈당계(Lifescan, Inc., USA)를 이용하여 포도당 수치를 측정한 후 각 실험군별로 평균값을 나타내었다.The mice were fasted for 7 hours at 0, 2, 4, 6, 8, 10, and 12 weeks after the fasting, and blood samples were collected from the tail veins of experimental rats. After the measurement of glucose level, the average value was shown for each experimental group.

< 표 2 > 12주간 실험용 쥐의 혈중 포도당 수치변화(mg/㎗)<Table 2> Changes in blood glucose level in experimental rats for 12 weeks (mg / ㎗)

0주0 weeks 2주2 weeks 4주4 weeks 6주6 weeks 8주8 weeks 10주10 weeks 12주12 weeks 대조군 Control group 232.9232.9 252.7252.7 293.8293.8 337.9337.9 391.2391.2 410.3410.3 415.1415.1 상엽군 Sangyeop 220.7220.7 262.8262.8 292.9292.9 320.0320.0 347.9347.9 395.3395.3 387.3387.3 홍삼군 Red ginseng 235.7235.7 256.0256.0 300.2300.2 332.2332.2 347.0347.0 391.5391.5 370.9370.9 바나바엽군 Barnacles 225.8225.8 276.8276.8 297.6297.6 322.0322.0 344.0344.0 399.8399.8 395.1395.1 혼합군 Mixed group 216.6216.6 276.8276.8 291.2291.2 310.7310.7 341.4341.4 388.2388.2 364.7364.7

상기 < 표 2 >의 결과에서와 같이 혈중 포도당 수치의 변화는 도 1의 그래프로 도시되어 있으며, 대조군의 경우 2주 후부터 250mg/㎗ 이상의 고혈당이 유발되면서 꾸준히 증가하는 것을 알 수 있고, 상엽군, 홍삼군, 바나바엽군, 혼합군은 모두 실험용 식이의 섭취 후 6주까지는 대조군과 뚜렷한 차이를 나타내지 않다가 8주째부터 대조군과 유의적인 차이를 나타내었으며, 최종 12주째에서는 혼합군>홍삼군>상엽군>바나바엽군 순으로, 본 발명에 따른 기능성 식품을 실험용 식이로 사용한 혼합군이 혈당강하 효과가 가장 큰 것으로 나타났다.As shown in the results of Table 2, the change of blood glucose level is shown in the graph of FIG. 1, and in the case of the control group, hyperglycemia of 250 mg / dl or more is induced from 2 weeks onwards, Red ginseng group, barnacle group, and mixed group showed no significant difference from the control group at 6 weeks after the intake of the experimental diets, but there was a significant difference from the control group at 8 weeks. In the final 12 weeks, the mixed group> red ginseng group> , &Lt; / RTI &gt; barnacus lobata, and the combination of the functional foods according to the present invention and experimental diets.

② 혈중 당화 헤모글로빈의 측정② Measurement of glycated hemoglobin in blood

실험기간 중 0, 2, 4, 6, 8, 10, 12주째에 각각 실험용 쥐들을 7시간 절식시킨 후 공복상태에서 실험용 쥐의 안와정맥에서 채혈하고 원심분리기로 3,000rpm에서 15분간 원심분리 후 얻어진 혈장을 사용하여 혈중 당화 헤모글로빈 HbA1C의 농도 를 측정하였으며, 측정법은 cation exchange chromatography법에 기초한 kit(Biosystem S. S., Spain)를 사용하여 측정한 후 각 실험군별로 평균값을 나타내었다.Experimental rats were fasted for 7 hours at 0, 2, 4, 6, 8, 10, and 12 weeks in the experimental period. Blood was collected from the orbital vein of the experimental rats under fasting conditions and centrifuged at 3,000 rpm for 15 minutes Serum glycated hemoglobin HbA 1 C concentration was measured using plasma, and the measurement was performed using a kit based on cation exchange chromatography (Biosystem SS, Spain).

< 표 3 > 12주간 실험용 쥐의 혈중 당화 헤모글로빈 수치변화(%)<Table 3> Changes in glycated hemoglobin in blood of experimental rats for 12 weeks (%)

0주0 weeks 2주2 weeks 4주4 weeks 6주6 weeks 8주8 weeks 10주10 weeks 12주12 weeks 대조군 Control group 5.735.73 7.067.06 7.157.15 8.038.03 9.319.31 11.3411.34 12.6412.64 상엽군 Sangyeop 5.435.43 7.037.03 6.526.52 6.066.06 7.957.95 9.109.10 10.4110.41 홍삼군 Red ginseng 6.006.00 6.246.24 5.875.87 6.026.02 8.858.85 8.458.45 8.998.99 바나바엽군 Barnacles 5.465.46 7.627.62 5.365.36 6.146.14 8.258.25 9.749.74 10.8210.82 혼합군 Mixed group 5.285.28 6.166.16 5.105.10 6.036.03 8.128.12 8.408.40 8.558.55

당뇨병의 경우 고혈당 상태가 지속되면서 효소에 의해 매개되지 않는 당화반응이 일어나게 되며 혈색소 역시 이에 따른 영향을 받아 혈중 포도당과 결합하여 당화 헤모글로빈을 형성하게 되고, 상기 당화 헤모글로빈은 미세혈관 합병증을 발병시키는 원인이 되어 각종 혈관 질환이 유발된다. In the case of diabetes, hyperglycemia persists and a glycation reaction which is not mediated by the enzyme occurs, and hemoglobin is also influenced thereby to form glycated hemoglobin, and the glycated hemoglobin causes the microvascular complication And various vascular diseases are induced.

상기 < 표 3 >의 결과에서와 같이 혈중 당화 헤모글로빈의 수치변화는 도 2의 그래프로 도시되어 있으며, 대조군의 경우 혈중 당화헤모글로빈의 수치가 지속적으로 증가하는 반면 상엽군, 홍삼군, 바나바엽군, 혼합군은 대조군에 비해 당화헤모글로빈의 증가율이 크게 둔화됨을 알 수 있고, 특히 홍삼군과 본 발명에 따른 기능성 식품을 실험용 식이로 사용한 혼합군은 2주 경과후 부터 대조군과 유의적인 차이를 보여 혈중 당화헤모글로빈의 발생을 억제시키는데 가장 큰 효과를 지닌 것으로 나타났다.As shown in the results of Table 3, the change in blood glycated hemoglobin is shown in the graph of FIG. 2. In the control group, the blood glycated hemoglobin level continuously increases, while the blood glucose level, red ginseng group, Group showed significantly slower increase of glycosylated hemoglobin compared to the control group. Especially, the mixed group of the red ginseng group and the functional food according to the present invention was significantly different from the control group after 2 weeks, And it was shown to have the greatest effect in suppressing the occurrence of

③ 혈중 인슐린 측정③ blood insulin measurement

실험기간 중 0, 2, 4, 6, 8, 10, 12주째에 실험용 쥐들을 각각 7시간 절식시킨 후 공복상태에서 실험용 쥐의 안와정맥에서 채혈하고 원심분리기로 3,000rpm에서 15분간 원심분리 후 얻어진 혈장을 사용하여 혈중 인슐린 농도를 측정하였으며, 측정법은 anti-mouse antibody를 이용한 insulin enzyme immunoassay kit(Linco Research, Inc., USA)를 사용하여 측정한 후 각 실험군별로 평균값을 나타내었다.Experimental rats were fasted for 7 hours at 0, 2, 4, 6, 8, 10, and 12 weeks in the experimental period. Blood was collected from the orbital vein of the rats in fasting state and centrifuged at 3,000 rpm for 15 minutes Plasma was used to measure insulin concentrations in the blood. The measurements were made using an insulin enzyme immunoassay kit (Linco Research, Inc., USA) using an anti-mouse antibody.

< 표 4 > 12주간 실험용 쥐의 혈중 인슐린 수치변화(ng/㎖)Changes in insulin levels in the blood of rats for 12 weeks (ng / ml)

0주0 weeks 2주2 weeks 4주4 weeks 6주6 weeks 8주8 weeks 10주10 weeks 12주12 weeks 대조군 Control group 2.182.18 3.163.16 3.953.95 4.394.39 5.505.50 7.397.39 9.39.3 상엽군 Sangyeop 2.192.19 3.153.15 3.993.99 4.324.32 4.924.92 5.525.52 6.016.01 홍삼군 Red ginseng 2.202.20 3.133.13 3.883.88 4.214.21 4.504.50 5.105.10 5.555.55 바나바엽군 Barnacles 2.152.15 3.203.20 3.943.94 4.304.30 5.105.10 5.665.66 6.246.24 혼합군 Mixed group 2.172.17 3.173.17 3.843.84 4.194.19 4.324.32 4.924.92 5.075.07

제 2형 당뇨병은 인슐린의 분비가 정상임에도 불구하고 혈당의 인슐린에 대한 내성이 증가하여 인슐린 저항성을 지니게 되고 이로 인해 혈중 인슐린의 양이 증가하여 각종 대사장애가 발생되는 문제점이 있는 것으로, 상기 < 표 4 >의 결과에서와 같이 혈중 인슐린의 수치변화는 도 3의 그래프로 도시되어 있으며, 대조군의 경우 혈중 인슐린의 수치가 지속적으로 증가하는 반면 상엽군, 홍삼군, 바나바엽군, 혼합군은 8주째 부터 대조군에 비해 인슐린의 증가율이 크게 둔화됨을 알 수 있고, 특히 홍삼군과 본 발명에 따른 기능성 식품을 실험용 식이로 사용한 혼합군은 실험 12주째에 대조군의 인슐린 수치와 비교시 각각 59.7%, 54.5%에 해당하는 감소된 수치를 나타내어 제 2형 당뇨병의 문제점인 인슐린에 대한 저항성을 개선시켜 주는데 큰 효과가 있음을 알 수 있다.Although type 2 diabetes is normal in the secretion of insulin, the insulin resistance of blood glucose is increased to have insulin resistance, which causes an increase in the amount of insulin in the blood, resulting in various metabolic disorders. As shown in the graph of FIG. 3, the blood insulin level changes as shown in the graph of FIG. 3. In the control group, the blood insulin level continuously increased, whereas the upper group, red ginseng group, In contrast, in the mixed group of the red ginseng group and the functional food according to the present invention as the experimental diets, the insulin levels of the control group were 59.7% and 54.5%, respectively, at the 12th week of the experiment , Indicating a significant effect in improving the resistance to insulin, a problem of type 2 diabetes. Can.

④ 혈중 랩틴(leptin)과 중성지방의 수치④ Serum levels of leptin and triglycerides

실험 12주째에 실험용 쥐들을 7시간 절식기킨 후 심장채혈하여 원심분리기로 혈청을 분리한 다음 렙틴을 Mouse Leptin RIA kit(Linco Research, USA)를 이용하여 측정하였고 중성지방은 McGrown 방법을 근거로 한 kit(Green Cross, Korea)를 이용하여 각각 측정한 후 각 실험군별로 평균값을 나타내었다.At 12 weeks after the experiment, rats were sacrificed for 7 hours, cardiac blood was collected, serum was separated by centrifuge, and leptin was measured by Mouse Leptin RIA kit (Linco Research, USA) kit (Green Cross, Korea), and the average value was shown for each experimental group.

< 표 5 > 실험 12주째에서의 실험용 쥐의 혈중 렙틴 및 중성지방의 수치<Table 5> Levels of leptin and triglyceride in experimental rats at 12 weeks of experiment

렙틴(ng/㎖) Leptin (ng / ml) 중성지방(mg/㎖)Triglyceride (mg / ml) 대조군 Control group 95.1495.14 150.4150.4 상엽군 Sangyeop 72.0272.02 125.04125.04 홍삼군 Red ginseng 68.7668.76 124.4124.4 바나바엽군 Barnacles 82.6482.64 140.6140.6 혼합군 Mixed group 59.5359.53 104.6104.6

렙틴은 혈중에 존재하는 항비만 호르몬으로 주로 지방조직에서 분비되어 혈액으로 들어가 단백질과 결합하게 되며 체내 지방이 증가할수록 렙틴의 분비량이 증가하게 되는 물질로서, 상기 < 표 5 >의 결과 및 도 4의 그래프에서와 같이 본 발명에 따른 기능성 식품을 실험용 식이로 하여 지속적으로 취식한 혼합군의 경우 대조군의 62.57%에 해당하는 감소된 혈중 렙틴수치를 나타내어 본 발명에 따른 기능성 식품이 렙틴 분비를 감소시키는 것을 알 수 있었다.Leptin is an anti-obesity hormone existing in the blood. Leptin is secreted mainly from adipose tissue, enters the blood and binds to proteins. As the body fat increases, leptin secretion increases. The results of Table 5 and FIG. As shown in the graph, in the case of the mixed group in which the functional food according to the present invention was continuously used as a dietary supplement, the reduced blood leptin level corresponding to 62.57% of the control group showed that the functional food according to the present invention decreased leptin secretion Could know.

또한, 제 2형 당뇨병환자들에서 흔히 볼 수 있는 지질대사 이상으로 인한 고지혈증은 고중성지방혈증이 가장 높은 빈도로 나타나며 이와 같이 혈중 중성지방의 증가는 인슐린 저항성을 촉진시켜 혈당조절을 더욱 악화시키게 되는 요인이 되는 것으로, 상기 < 표 5 >의 결과 및 도 5의 그래프에서와 같이 본 발명에 따른 기능성 식품을 실험용 식이로 하여 지속적으로 취식한 혼합군의 경우 대조군의 69.54%에 해당하는 감소된 혈중 중성지방 수치를 나타내어 본 발명에 따른 기능성 식품이 혈중 중성지방의 농도를 감소시키는 것을 알 수 있었다.In addition, hyperlipidemia due to lipid metabolism abnormality, which is commonly seen in patients with type 2 diabetes, is most frequently observed in hypertriglyceridemia, and the increase in blood triglycerides further promotes insulin resistance and exacerbates blood glucose control As shown in the results of Table 5 and the graph of FIG. 5, in the mixed group in which the functional food according to the present invention was used as the experimental diets, the reduced blood neutrality corresponding to 69.54% of the control group Fat level, indicating that the functional food according to the present invention reduces the concentration of triglyceride in blood.

상기와 같이 본 발명에 의하면 기존의 양약 대신 천연식물재료로서 인삼분말과 상엽추출물분말과 바나바엽추출물분말을 일정비율로 혼합하여 제조된 기능성 식품을 건강 식품으로 취식함으로써 인체에 거부감이나 부작용이 없어 누구나 쉽게 복용할 수 있으며, 본 발명에 따른 기능성 식품을 장기 취식할 경우 인체의 혈중 포도당 감소, 혈중 당화헤모그로빈의 감소, 혈중 인슐린의 감소로 인하여 제 2형 당뇨병의 예방 및 치료에 큰 효과가 있으며, 또한 혈중 랩틴(leptin)의 농도와 중성지방의 농도를 크게 낮추어 주어 비만예방 및 심장순환기계통의 질환 예방에 큰 효과가 있다. As described above, according to the present invention, a functional food prepared by mixing a ginseng powder, a leaf extract and a leaf extract of a barbara leaf as a natural plant material instead of a conventional medicinal plant as a health food, When the functional food according to the present invention is used for a long period of time, it has a great effect on the prevention and treatment of type 2 diabetes due to reduction of blood glucose in the human body, decrease of blood glycated hemoglobin, and decrease of blood insulin, The concentration of blood leptin (leptin) and the concentration of triglycerides are greatly lowered, which is very effective in preventing obesity and preventing diseases of the cardiovascular system.

Claims (5)

통상의 방법으로 건조 분쇄된 인삼분말과, 추출탱크에 상엽을 넣고 상엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 40 ~ 60Brix로 농축하여 살균처리한 다음 건조하여 제조된 상엽추출물분말과, 추출탱크에 바나바엽을 넣고 바나바엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 40 ~ 60Brix로 농축하여 살균처리한 다음 건조하여 제조된 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하여 제조되는 것을 특징으로 하는 인삼과 상엽과 바나바엽을 주재로 한 혈당강하용 기능성 식품.The dried ginseng powder and the leaf of the dried ginseng powder were put into the extraction tank and 8 ~ 10 times of purified water was added to the total weight of the upper leaves. The extract was then extracted with water for 8 ~ 10 hours. The extract was filtered and concentrated to 40 ~ 60 Brix The extracts were then filtered, and the filtrate was concentrated to 40-60 Brix. The extracts were washed with distilled water, dried over anhydrous magnesium sulfate, Which is prepared by mixing ginsenosides, ginsenosides, ginsenosides, ginsenosides, ginsenosides, ginsenosides, fungicides, fungicides, fungicides, yeast extracts, 통상의 방법으로 건조 분쇄된 인삼분말과, 추출탱크에 상엽을 넣고 상엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 40 ~ 60Brix로 농축하여 살균처리한 다음 건조하여 제조된 상엽추출물분말과, 추출탱크에 바나바엽을 넣고 바나바엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 40 ~ 60Brix로 농축하여 살균처리한 다음 건조하여 제조된 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하고 상기 혼합물에 대하여 누에분말 0.5 ~ 2중량부와 비타민 B1 0.5 ~ 2중량부와 비타민 B2 0.5 ~ 2중량부와 실크아미노산 0.5 ~ 2중량부를 첨가하여 캡슐형태나 타블렛 또는 과립형태로 제조되는 것을 특징으로 하는 인삼과 상엽과 바나바엽을 주재로 한 혈당강하용 기능성 식품.The dried ginseng powder and the leaf of the dried ginseng powder were put into the extraction tank and 8 ~ 10 times of purified water was added to the total weight of the upper leaves. The extract was then extracted with water for 8 ~ 10 hours. The extract was filtered and concentrated to 40 ~ 60 Brix The extracts were then filtered, and the filtrate was concentrated to 40-60 Brix. The extracts were washed with distilled water, dried over anhydrous magnesium sulfate, 0.5 to 2 parts by weight of silkworm powder, 0.5 to 2 parts by weight of vitamin B 1 and 0.5 to 2 parts by weight of vitamin B 2 and 0.5 to 2 parts by weight of vitamin B 2 0.5 And 0.5 to 2 parts by weight of a silk amino acid are added to prepare a capsule or a tablet or a granule. The functional food for controlling blood glucose lowering based on ginseng, upper leaves and barnacle leaves Width. 통상의 방법으로 건조 분쇄된 인삼분말과, 추출탱크에 상엽을 넣고 상엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 40 ~ 60Brix로 농축하여 살균처리한 다음 건조하여 제조된 상엽추출물분말과, 추출탱크에 바나바엽을 넣고 바나바엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 40 ~ 60Brix로 농축하여 살균처리한 다음 건조하여 제조된 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하고 상기 혼합물에 대하여 누에분말 0.5 ~ 2중량부와 비타민 B1 0.5 ~ 2중량부와 비타민 B2 0.5 ~ 2중량부와 실크아미노산 0.5 ~ 2중량부를 첨가하여 기능성 식품을 제조하고 상기 기능성 식품을 통상의 음료 전체 중량에 대하여 0.1 ~ 10중량% 포함된 상태로 첨가하여 음료형태로 제조되는 것을 특징으로 하는 인삼과 상엽과 바나바엽을 주재로 한 혈당강하용 기능성 식품.The dried ginseng powder and the leaf of the dried ginseng powder were put into the extraction tank and 8 ~ 10 times of purified water was added to the total weight of the upper leaves. The extract was then extracted with water for 8 ~ 10 hours. The extract was filtered and concentrated to 40 ~ 60 Brix The extracts were then filtered, and the filtrate was concentrated to 40-60 Brix. The extracts were washed with distilled water, dried over anhydrous magnesium sulfate, 0.5 to 2 parts by weight of silkworm powder, 0.5 to 2 parts by weight of vitamin B 1 and 0.5 to 2 parts by weight of vitamin B 2 and 0.5 to 2 parts by weight of vitamin B 2 0.5 And 0.5 to 2 parts by weight of silk amino acid are added to prepare a functional food, and the functional food is added in a form of being contained in an amount of 0.1 to 10% by weight based on the total weight of the ordinary beverage, A functional food for blood glucose lowering based on ginseng, upper leaves and barnaby leaves. 제 1항 내지 제 3항 중 어느 한 항에 있어서, 상기 인삼분말은 홍삼을 건조 분말화한 홍삼분말인 것을 특징으로 하는 인삼과 상엽과 바나바엽을 주재로 한 혈당강하용 기능성 식품.The functional food for reducing blood glucose according to any one of claims 1 to 3, wherein the ginseng powder is red ginseng powder in which red ginseng is made into a dry powder, based on ginseng, upper leaves and barnacle leaves. 통상의 방법으로 건조 분쇄한 인삼분말과, 추출탱크에 상엽을 넣고 상엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하여 살균처리한 다음 건조하여 제조한 상엽추출물분말과, 추출탱크에 바나바엽을 넣고 바나바엽의 전체중량에 대하여 8 ~ 10배의 정제수를 가하여 80 ~ 90℃에서 8 ~ 10시간 동안 물추출한 후 추출액을 여과하고 45 ~ 60℃에서 40 ~ 60Brix로 감압농축하여 살균처리한 다음 건조하여 제조한 바나바엽추출물분말을 1 : 1 : 1의 중량비로 혼합하여 기능성 식품을 제조하고 상기 기능성 식품을 캡슐형태나 타블렛 또는 과립형태로 제조하거나, 또는 상기 기능성 식품을 통상의 음료 전체 중량에 대하여 0.1 ~ 10중량% 포함된 상태로 첨가하여 음료형태로 제조하는 것을 특징으로 하는 인삼과 상엽과 바나바엽을 주재로 한 혈당강하용 기능성 식품의 제조방법. The ginseng powder which is dried and pulverized by a conventional method and the upper leaves are put into an extraction tank, and 8-10 times of purified water is added to the total weight of the upper leaves. Water is extracted at 80 to 90 ° C for 8 to 10 hours, The extracts of the leaf extracts prepared by sterilizing the concentrate at a reduced pressure of 40 to 60 Brix at 60 ° C and then dried, and barnyard leaves in an extraction tank, adding 8 to 10 times of purified water to the total weight of the barnyard leaves, After extracting with water for 8 ~ 10 hours, the extract was filtered, concentrated under reduced pressure at 45 ~ 60 ° C and sterilized at 40 ~ 60Brix, and then dried. The extract was mixed with 1: 1: 1 weight ratio of functional food. And the functional food is prepared in the form of a capsule, a tablet or a granule, or the functional food is added in an amount of 0.1 to 10% by weight based on the total weight of the ordinary beverage, The method of characterized in that the crude ginseng and upper and blood glucose lowering functional food for a Barnabas as main lobe.
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CN103099140A (en) * 2011-11-11 2013-05-15 西南科技大学 Mulberry pulp freeze-drying tablet and process thereof
CN103251045A (en) * 2012-04-23 2013-08-21 乔德京 Health food for assistedly reducing blood lipid
KR102106152B1 (en) * 2018-11-13 2020-05-04 신원수 Manufacturing method of sambungnyawa jelly and the jellies thereby

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