CN104839688A - Eye care preparation and preparation method thereof - Google Patents

Eye care preparation and preparation method thereof Download PDF

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Publication number
CN104839688A
CN104839688A CN201510186355.9A CN201510186355A CN104839688A CN 104839688 A CN104839688 A CN 104839688A CN 201510186355 A CN201510186355 A CN 201510186355A CN 104839688 A CN104839688 A CN 104839688A
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China
Prior art keywords
preparation
lutein ester
embedded
astaxanthin
health care
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CN201510186355.9A
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Chinese (zh)
Inventor
徐永刚
苏华
吕嘉
杨坤
王志良
张振华
韩军涛
管明亮
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North China Pharmaceutical Qinhuangdao Co Ltd
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North China Pharmaceutical Qinhuangdao Co Ltd
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Priority to CN201510186355.9A priority Critical patent/CN104839688A/en
Publication of CN104839688A publication Critical patent/CN104839688A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses an eye care preparation. The eye care preparation comprises, by weight, 0.002-10 parts of lutein ester, 0.002-2 parts of zeaxanthin and 0.002-2 parts of astaxanthin. Lutein ester, zeaxanthin and astaxanthin are compounded to generate synergism, so the bioavailability of the lutein ester is improved, and the lutein ester can be easily absorbed by human body. A stepwise layered embedding preparation technology is adopted in the preparation process, and is characterized in that a lutein ester and embedding material mixture is adopted as an embedding material to embed astaxanthin, a zeaxanthin and embedding material mixture is adopted as an embedding material to carry out secondary embedding, and the above embedding material is adopted to carry out tertiary embedding, so the stability of the lutein ester and zeaxanthin is improved, the synergism of the lutein ester, zeaxanthin and astaxanthin is well displayed, and the absorption availability of the lutein ester is high, thereby the eye care preparation has a substantial improvement effect on shortsightedness and amblyopia.

Description

A kind of eye health care preparation and preparation method thereof
Technical field
The invention belongs to food and field of health care products, be specifically related to a kind of pre-myopia prevention, control myopia progression and improve myopia, and effectively prevent illness in eye, a kind of eye health care preparation supplementing eyes nutrition and preparation method thereof.
Background technology
Lutein ester is a kind of important carotenoid, is extensively present in fruit, vegetables, flowers.Lutein ester changes free lutein crystal into and enters before blood is absorbed by the body under lipase effect, plays its work ﹙ Meng Zhe, Liu Hongyun " introduction of Xanthophyll " and comes from " chemical education " the 3rd phase ﹚ in 2007.Research shows, lutein ester has following physiologically active: the oxidation resistance (Li great Jing etc., lutein ester and lutein antioxidation compare, Chinese food journal, 2008, No5) that (1) is stronger; (2) AMD purposes (Zhang Hui etc., the function and application of natural high-purity lutein ester, Food Additives Used in China, 2008, No1) is prevented: the important biological function of of lutein protects retina exactly, prevents ultraviolet damage.At present, the senile macular degeneration (AMD) that the whole world finds is the main diseases causing blindness of over-65s crowd.Lutein is deposited in people's fundus flavimaculatus with high concentration, can be used as the absorbent of ultraviolet blue light, by catching free radical, the injury that prevents or reduce oxidation and radical pair retina to bring and play defencive function, effectively can reduce the incidence of AMD.Research shows that in healthy population and initial stage AMD patient, supplement lutein can significantly improve macula retinae pigment density.By lutein antioxidant supplement test confirm, after AMD patient augments lutein, the macular pigment optical density of study subject improves 50%, and eyes function also arrived suitable improvement; (3) in addition, lutein also has enhancing immunization and the effect of the skin care guarantor heart.
Mankind itself can not synthesize lutein, and therefore must place one's entire reliance upon meal supplement, to meet the whole demands of body to lutein.Public health investigation display, take in the risk that 6-10 milligram lutein just can help to prevent senile disease of eye every day, but the quantity that the current common people absorb lutein in diet can not reach above-mentioned standard from diet and nutritious supplementary pharmaceutical.
Generally exist with the form of ester at marigold Lutein, but highly acid scope is to the stability influence of lutein ester and lutein comparatively large (Li great Jing etc., " research of lutein ester and lutein stability ", chemistry of forest product and industry, vol.27, No.1,2007,112-116).For lutein monosomic utilization rate for 100%, the relative bioavailability of lutein ester only has 18.55%, large portion can not be made full use of (Hui Baidi, Zhang Lingxiao, Zhang Yan by human body, " lutein ester relative bioavailability in vivo ", Food Science, 2009, vol.30, No.3,253-256).This experiment adopts oral, more can embody lutein and the conversion of lutein ester in human body.
Astaxanthin has very strong antioxidation and unique physiological function; effectively can prevent the damage of amphiblestroid oxidation and photoreceptor cell; at prevention and therapy/AMD, improve in retinal function there is good result, and there is the ability of protection central nervous system.(Liu Hongchao, Yang Dan " from shrimp shell, extracting astaxanthin technique and bioactive application progress thereof ", chemical reagent, 2009,31(2), 105-108)
Astaxanthin is unstable in acid situation, (Zhang Yingxia, military profit just waits " extraction of astaxanthin and stability study thereof " modern food science, 2008, vol.24, No.12,1288-1291) destruction of astaxanthin must reduce along with pH value and aggravate, that is under hydrochloric acid in gastric juice condition, astaxanthin is easy to be destroyed, and can not be made full use of by human body.
Summary of the invention
The technical issues that need to address of the present invention are to provide a kind of eye health care preparation based on lutein ester and preparation method thereof; said preparation can improve the stability of lutein ester, astaxanthin; play lutein ester, luteole and astaxanthin synergy; significantly improve the bioavilability of lutein ester; protection eyes; the illness in eye such as the nearly amblyopia of effective prevention and corntrol eyes and Macular pathology, and have certain therapeutic action to illness in eye.
For solving the problem, the technical solution used in the present invention is:
A kind of eye health care preparation, it comprises the major ingredient of following weight portion: lutein ester 0.002 ~ 10 part, luteole 0.002 ~ 2 part, astaxanthin 0.002 ~ 2 part.
Further, described eye health care preparation also comprises the auxiliary material of following weight portion: extract 0 ~ 8 part, flavouring 0 ~ 60 part, acid 0 ~ 5 part, starch 0 ~ 60 part, 0 ~ 15 part, dextrin, dolomol 0 ~ 5 part, flavoring essence 0 ~ 1 part.
Preferably, described extract is any one or the two or more composition in water-soluble dietary fiber, collagen, DHA, taurine, bata-carotene, blueberry extract, blackcurrant extract, hydrolysis yolk powder.
Preferably, described flavouring is any one or the two or more composition in sorbierite, lactitol, sweet mellow wine, maltitol, xylitol, antierythrite, trehalose, oligoisomaltose, reduced isomaltooligosaccharide, isomalt, stachyose, galactooligosaccharide, FOS, low polyxylose alcohol
Preferably, described acid is any one or the two or more composition in citric acid, malic acid, lactic acid, phosphoric acid, tartaric acid, natrium citricum, sodium lactate, vitamin C, fumaric acid.
Eye health care preparation of the present invention, based on lutein ester, carries out compounded combination with luteole and astaxanthin, improves the bioavilability of lutein ester, makes it be easier to be absorbed by the body, and improves curative effect.Based on the characteristic of lutein ester, luteole and astaxanthin, provide a kind of eye health care preparation preparation method, under its step:
1) 60 ~ 100 mesh sieves crossed by each raw material;
2) adopt embedded material to embed with microcapsule embedded method lutein ester, luteole and astaxanthin, embedded material adopts food-grade or pharmaceutical grade embedded material;
3) by step 2) gained microcapsules adopt conventional formulation method to make granule, capsule or tablet.
Further, described step 2) in microcapsule embedded method be that when adopting investment embedding step by step, its step is as follows directly by embedding after the mixing of lutein ester, luteole and astaxanthin or each component to be adopted investment embedding step by step:
(1) lutein ester and embedded material Homogeneous phase mixing are embedded thing as one-level, luteole and embedded material Homogeneous phase mixing are embedded thing as secondary;
(2) spray drying process one-level embedding thing is adopted to carry out microcapsule embedded to described astaxanthin;
(3) spray drying process secondary embedding thing is adopted to carry out second time to step (2) gained microcapsules microcapsule embedded;
(4) with embedded material, carried out to step (3) gained microcapsules third time microcapsule embedded.
Further, described in described step 3), the formulation process of granule is as follows:
1. by step 2) gained microcapsules and described extract, flavouring, acid, flavoring essence, starch and hydromining wet granulation;
2. by wet granular in 50 ~ 75 DEG C of oven dry;
3. mix after whole for dry particle grain with described dolomol, in order to packing or make tablet further.
Preferably, described embedded material is any one or the two or more combination in Arabic gum, pectin, xanthans, guar gum, angle fresh kidney beans, sodium alginate, carragheen, cycloheptaamylose, compound sugar, starch derivatives, gelatin, casein, soybean protein, lactalbumin, CMC, ethyl cellulose, methylcellulose, insect wax, paraffin or beeswax.
The beneficial effect adopting technique scheme to produce is: the present invention passes through lutein ester, luteole and astaxanthin compounded combination, synergy is created between three, improve the bioavilability of lutein ester, make it be easier to be absorbed by the body, to illness in eye such as the nearly amblyopias of improvement, there is significant effect.In order to ensure lutein ester, luteole and the astaxanthin stability in human body, what synergy was played is better, and during preparation, we adopt the preparation technology that layering step by step embeds, and improves the stability of lutein ester, astaxanthin.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail; should be understood that; below be only preferred embodiments more of the present invention; protection scope of the present invention is not limited in this; every not creative improvement done under spiritual principles of the present invention, all within protection scope of the present invention.Unless stated otherwise, in the present invention, all numbers are parts by weight, and percentage is all weight percentage, and useful water is purified water.
Embodiment 1 ~ 10
Following table is the component data of eye health care preparation embodiment 1 ~ 10 of the present invention:
Embodiment 1 2 3 4 5 6 7 8 9 10
Lutein ester 1.9 2.67 0.002 0.09 6 1.91 2.67 7 10 0.002
Luteole 0.4 0.65 2 1.5 1.19 0.53 1.2 1.8 0.002 2
Astaxanthin 0.5 0.6 2 0.8 1.2 0.53 1.3 1.5 0.002 0.002
Flavouring 0 0 18.6 9.6 37.6 13.4 17.6 46.35 45.3 9.5
Extract 0 0 8 3.8 2 0.65 6 0.9 0.5 7
Starch 0 0 18 10 37.6 14 16.7 46.6 45 9.6
Dextrin 0 0 4.8 2.13 9.4 3.34 4.1 11.8 12 2.46
Acid 0 0 0.2 0.1 2 0.08 0.6 3 5 0.1
Dolomol 0 0 0.26 0.09 0.47 0.16 0.17 0.6 0.65 0.14
Flavoring essence 0 0 0.1 0.05 1 0.02 0.6 0.8 1 0.08
In embodiment 3 ~ 6, extract used is followed successively by: DHA, hydrolysis yolk powder, bata-carotene and blueberry extract, flavouring used is followed successively by: xylitol, sorbierite, lactitol and sweet mellow wine, and acid used is followed successively by: citric acid, malic acid, lactic acid and sodium lactate.
In embodiment 7 ~ 10, extract used is followed successively by: water-soluble dietary fiber, collagen, taurine and blackcurrant extract; flavouring used is followed successively by: maltitol, antierythrite, trehalose and oligoisomaltose, and acid used is followed successively by: tartaric acid, natrium citricum, vitamin C and fumaric acid.
Preparation method A
1) each raw material is crossed 60 ~ 100 mesh sieves, lutein ester, luteole and astaxanthin mix, and then adopt microcapsule embedded method CMC to embed as embedded material;
2) conventional formulation method is adopted to make granule.
Preparation method B
1) each raw material is crossed 60 ~ 100 mesh sieves;
2) lutein ester and Arabic gum Homogeneous phase mixing are embedded thing as one-level, luteole and cycloheptaamylose Homogeneous phase mixing are embedded thing as secondary;
3) the described one-level embedding thing of spray drying process is adopted to carry out microcapsule embedded to astaxanthin;
4) spray drying process described secondary embedding thing is adopted to carry out second time to step 3) gained microcapsules microcapsule embedded;
5) with beeswax, carried out to step 4) gained microcapsules third time microcapsule embedded;
6) conventional formulation method is adopted to make capsule.
Preparation method C
1) each raw material is crossed 60-100 mesh sieve; Lutein ester, luteole and astaxanthin are mixed, then adopts microcapsule embedded method gelatin to carry out microcapsule embedded;
2) step 1) gained microcapsules and described extract, flavouring, acid, flavoring essence, starch and hydromining wet granulation;
3) by wet granular in 50 ~ 75 DEG C of oven dry;
4) mix after whole for dry particle grain with described dolomol, packing, compressing tablet becomes tablet.
Preparation method D
1) each raw material is crossed 60 ~ 100 mesh sieves;
2) lutein ester and lactalbumin Homogeneous phase mixing are embedded thing as one-level, luteole and xanthans Homogeneous phase mixing are embedded thing as secondary;
3) the described one-level embedding thing of spray drying process is adopted to carry out microcapsule embedded to described astaxanthin;
4) spray drying process described secondary embedding thing is adopted to carry out second time to step 3) gained microcapsules microcapsule embedded;
5) with beeswax, carried out to step 4) gained microcapsules third time microcapsule embedded;
6) step 5) gained microcapsules and described extract, flavouring, acid, flavoring essence, starch and hydromining wet granulation;
7) by wet granular in 50 ~ 75 DEG C of oven dry;
8) mix after whole for dry particle grain with described dolomol, packing or compressing tablet.
the effect experimental of technical solution of the present invention
Experimental example 1
Composition described in embodiment 1 is prepared into the granule of lutein ester luteole astaxanthin according to preparation method A.
Experimental example 2
Composition described in embodiment 1 is prepared into the granule of lutein ester luteole astaxanthin according to preparation method B.
Comparative example 1
1.5 parts of lutein esters and 1 part of luteole are not had astaxanthin according to preparation method A() be prepared into the granule of lutein ester luteole.
Comparative example 2
1.5 parts of lutein esters and 1 part of astaxanthin are not had luteole according to preparation method A() be prepared into the granule of lutein ester luteole.
Get the experimental example of same amount lutein ester and four kinds of preparations of comparative example, under the environment of pH2.0 (simulation gastric acid environment), measure the light absorption value of preparation Lutein ester, measurement result is in table 1.
The preparation Lutein ester absorbance of experimental example and comparative example during table 1 pH2.0
From above result of the test, lutein ester, luteole and astaxanthin combine, and adopt step by step after layering embedding techniques, create synergy, substantially increase the stability of lutein ester between three.
Usage and the consumption of eye health care preparation of the present invention are: with lutein ester content meter, daily twice, and each serving with 6mg.
The eye health care preparation obtained by above experimental example and comparative example is adopted to carry out clinical testing, the nearly amblyope of 200 example, Macular pathology, cataract patient are divided into four groups at random, often organize 50 examples, take the eye health care granule of experimental example 1, experimental example 2, comparative example 1 and comparative example 2 by above usage and consumption respectively.
Often group takes out 10 clinical trial persons, and first time takes 12mg, measures the biological utilisation of lutein ester, the accumulation situation of lutein in serum after 2 hours, and adopt HPLC method to carry out qualitative and quantitative analysis to the lutein in serum, specific experiment data are as follows:
Table 2 clinical test results
Experimental example 1 Experimental example 2 Comparative example 1 Comparative example 2
The mean value of lutein monomer in 10 clinical trial person's serum 0.00208mg/ml 0.00221 mg/ml 0.000982 mg/ml 0.00125 mg/ml
Clinical testing is after 3 months, and it is effective for promoting more than 30% with eyesight, and eyesight promotes but is that effectively eyesight has no and significantly improves as invalid lower than 30%.Clinical test results is in table 5.
Table 3 clinical test results
From above clinical testing, after the combination of lutein ester, luteole and astaxanthin, compared with lutein ester respectively with the combination of luteole and astaxanthin, significantly improve the bioavilability of lutein ester, and then improve the effect that said preparation treats nearly amblyopia, adopt layering embedding techniques step by step, improve the stability of lutein ester and astaxanthin, give full play to the synergy of three, improve the bioavilability of lutein ester further.
In order to improve the quality of preparation, it is made to be suitable for patient widely, improve the taste etc. of preparation, the present invention adds some auxiliary materials on the basis of lutein ester, luteole and astaxanthin major ingredient, simultaneously, in order to make its applicable mass production, improving preparation mobility in the fabrication process and lubricity, adding auxiliary material dolomol; As shown in embodiment 3 ~ 10.
Wherein increasing extract is to increase some nutritional labelings to eyes in useful and children's eyes growth and development, improve the quality of preparation, give full play to the curative effect of preparation, play booster action to patient's rehabilitation as early as possible simultaneously.
Flavouring, acid, flavoring essence, in order to improve or to shield the taste of medicine, make patient patient be easy to accept.
Starch is used as filler, adhesive, improves the content of monomer of medicine as filler, and as adhesive in granulation and tableting processes.
Dextrin is as filler, and as the additive of starch, object reduces the viscosity of starch, makes the preparation made be easy to stripping.
Dolomol is mainly used as lubricant, antiplastering aid, glidant.For the granulation of medicine, the particle made is made to have good mobility and compressibility.Glidant is used as in direct tablet compressing.
The present invention adds the specific embodiment of auxiliary material as shown in embodiment 3 ~ 10, wherein embodiment 3 ~ 6 adopts preparation method C to produce, embodiment 7 ~ 10 adopts preparation method D to produce, and the curative effect of each embodiment is verified, draw by experiment: embodiment 3 ~ 6 has with experimental example 1 effect be equal to, embodiment 7 ~ 10 has with experimental example 2 effect be equal to.Meanwhile, patient reflects that the preparation of embodiment 3 ~ 10 is delicious, acceptant especially, and especially child patient, more gladly accepts.

Claims (9)

1. an eye health care preparation, is characterized in that: it comprises the major ingredient of following weight portion: lutein ester 0.002 ~ 10 part, luteole 0.002 ~ 2 part, astaxanthin 0.002 ~ 2 part.
2. a kind of eye health care preparation according to claim 1, characterized by further comprising the auxiliary material of following weight portion: extract 0 ~ 8 part, flavouring 0 ~ 60 part, acid 0 ~ 5 part, starch 0 ~ 60 part, 0 ~ 15 part, dextrin, dolomol 0 ~ 5 part, flavoring essence 0 ~ 1 part.
3. a kind of eye health care preparation according to claim 2, is characterized in that described extract is any one or two or more compositions in water-soluble dietary fiber, collagen, DHA, taurine, bata-carotene, blueberry extract, blackcurrant extract, hydrolysis yolk powder.
4. a kind of eye health care preparation according to claim 2, is characterized in that described flavouring is any one or two or more compositions in sorbierite, lactitol, sweet mellow wine, maltitol, xylitol, antierythrite, trehalose, oligoisomaltose, reduced isomaltooligosaccharide, isomalt, stachyose, galactooligosaccharide, FOS, low polyxylose alcohol.
5. a kind of eye health care preparation according to claim 2, is characterized in that described acid is any one or two or more compositions in citric acid, malic acid, lactic acid, phosphoric acid, tartaric acid, natrium citricum, sodium lactate, vitamin C, fumaric acid.
6. a kind of eye health care preparation preparation method according to claim 1, under its step:
1) 60 ~ 100 mesh sieves crossed by each raw material;
2) adopt embedded material to embed with microcapsule embedded method lutein ester, luteole and astaxanthin, embedded material adopts food-grade or pharmaceutical grade embedded material;
3) by step 2) gained microcapsules adopt conventional formulation method to make granule, capsule or tablet.
7. a kind of eye health care preparation preparation method according to claim 6, it is characterized in that described step 2) in microcapsule embedded method be directly by embedding after the mixing of lutein ester, luteole and astaxanthin or each component to be adopted investment embedding step by step, when adopting investment embedding step by step, its step is as follows:
(1) lutein ester and embedded material Homogeneous phase mixing are embedded thing as one-level, luteole and embedded material Homogeneous phase mixing are embedded thing as secondary;
(2) spray drying process one-level embedding thing is adopted to carry out microcapsule embedded to described astaxanthin;
(3) spray drying process secondary embedding thing is adopted to carry out second time to step (2) gained microcapsules microcapsule embedded;
(4) with embedded material, carried out to step (3) gained microcapsules third time microcapsule embedded.
8. a kind of eye health care preparation preparation method according to claim 6, is characterized in that the formulation process of granule described in described step 3) is as follows:
1. by step 2) gained microcapsules and described extract, flavouring, acid, flavoring essence, starch and hydromining wet granulation;
2. by wet granular in 50 ~ 75 DEG C of oven dry;
3. mix after whole for dry particle grain with described dolomol, in order to packing or make tablet further.
9. a kind of eye health care preparation preparation method according to claim 6 or 7, is characterized in that described embedded material is any one or two or more combinations in Arabic gum, pectin, xanthans, guar gum, angle fresh kidney beans, sodium alginate, carragheen, cycloheptaamylose, compound sugar, starch derivatives, gelatin, casein, soybean protein, lactalbumin, CMC, ethyl cellulose, methylcellulose, insect wax, paraffin or beeswax.
CN201510186355.9A 2015-04-20 2015-04-20 Eye care preparation and preparation method thereof Pending CN104839688A (en)

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CN105105147A (en) * 2015-09-22 2015-12-02 哈尔滨宝德生物技术股份有限公司 Nutrition and health care supplement rich in lutein and astaxanthin as well as preparation method
CN105146539A (en) * 2015-09-22 2015-12-16 哈尔滨宝德生物技术股份有限公司 Xanthophyll and zeaxanthin containing nutritious food additive and preparing method
CN105343148A (en) * 2015-11-06 2016-02-24 王红霞 Eye care preparation
CN105901577A (en) * 2016-04-15 2016-08-31 胥永贵 Nutritional agent for reinforcing brain, protecting eye and strengthening body and preparation method and application thereof
CN106072584A (en) * 2016-07-13 2016-11-09 大兴安岭超越野生浆果开发有限责任公司 A kind of lutein ester and the compound edible health care product of Oleum Hippophae
CN107296278A (en) * 2017-07-10 2017-10-27 北京素维生物科技有限公司 A kind of function nutrition hardening agent composition and preparation method thereof
CN109287913A (en) * 2018-11-27 2019-02-01 云南爱尔康生物技术有限公司 A kind of drink and preparation method thereof improving visual fatigue
CN110013035A (en) * 2019-05-09 2019-07-16 青岛浩然海洋科技有限公司 A kind of compound powder production method of lutein and astaxanthin
CN110506879A (en) * 2018-08-07 2019-11-29 美安康质量检测技术（上海）有限公司 A kind of solid beverage and its preparation method for alleviating visual fatigue
CN111296729A (en) * 2020-02-17 2020-06-19 广西大学 Water-soluble astaxanthin product and preparation method thereof
CN111466567A (en) * 2020-04-22 2020-07-31 吉林农业大学 Preparation method of soybean protein emulsion gel rich in zeaxanthin and lutein
CN111713624A (en) * 2020-05-29 2020-09-29 同方药业集团有限公司 Solid beverage and preparation method and application thereof
CN114586979A (en) * 2022-03-12 2022-06-07 济宁职业技术学院 Preparation method of supplement capable of relieving asthenopia

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CN105146539A (en) * 2015-09-22 2015-12-16 哈尔滨宝德生物技术股份有限公司 Xanthophyll and zeaxanthin containing nutritious food additive and preparing method
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CN105343148A (en) * 2015-11-06 2016-02-24 王红霞 Eye care preparation
CN105901577A (en) * 2016-04-15 2016-08-31 胥永贵 Nutritional agent for reinforcing brain, protecting eye and strengthening body and preparation method and application thereof
CN106072584A (en) * 2016-07-13 2016-11-09 大兴安岭超越野生浆果开发有限责任公司 A kind of lutein ester and the compound edible health care product of Oleum Hippophae
CN107296278A (en) * 2017-07-10 2017-10-27 北京素维生物科技有限公司 A kind of function nutrition hardening agent composition and preparation method thereof
CN110506879A (en) * 2018-08-07 2019-11-29 美安康质量检测技术（上海）有限公司 A kind of solid beverage and its preparation method for alleviating visual fatigue
CN109287913A (en) * 2018-11-27 2019-02-01 云南爱尔康生物技术有限公司 A kind of drink and preparation method thereof improving visual fatigue
CN110013035A (en) * 2019-05-09 2019-07-16 青岛浩然海洋科技有限公司 A kind of compound powder production method of lutein and astaxanthin
CN111296729A (en) * 2020-02-17 2020-06-19 广西大学 Water-soluble astaxanthin product and preparation method thereof
CN111296729B (en) * 2020-02-17 2023-10-03 广西大学 Water-soluble astaxanthin product and preparation method thereof
CN111466567A (en) * 2020-04-22 2020-07-31 吉林农业大学 Preparation method of soybean protein emulsion gel rich in zeaxanthin and lutein
CN111713624A (en) * 2020-05-29 2020-09-29 同方药业集团有限公司 Solid beverage and preparation method and application thereof
CN114586979A (en) * 2022-03-12 2022-06-07 济宁职业技术学院 Preparation method of supplement capable of relieving asthenopia

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Application publication date: 20150819