CN114586979A - Preparation method of supplement capable of relieving asthenopia - Google Patents

Preparation method of supplement capable of relieving asthenopia Download PDF

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Publication number
CN114586979A
CN114586979A CN202210239756.6A CN202210239756A CN114586979A CN 114586979 A CN114586979 A CN 114586979A CN 202210239756 A CN202210239756 A CN 202210239756A CN 114586979 A CN114586979 A CN 114586979A
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vitamin
supplement
solution
relieving
gelatin
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董学卫
于传喜
夏雪
张志美
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Jining Polytechnic
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Jining Polytechnic
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention relates to the technical field of health care products, in particular to a preparation method of a supplement capable of relieving visual fatigue, which comprises the following components in parts by weight: natural lutein, zeaxanthin, astaxanthin, schizochytrium DHA, spirulina extract, vitamin A, vitamin E, vitamin B1, and vitamin B2; the invention adopts soft capsule preparation or tablet to effectively protect the easily oxidized components in the raw materials, has scientific composition, natural components, proper proportion, good taste and convenient taking, has the effects of supplying nutrient composition required by eyes and delaying oxidation, and is an ideal and high-end health food for relieving asthenopia.

Description

Preparation method of supplement capable of relieving asthenopia
Technical Field
The invention relates to the technical field of health care products, in particular to a preparation method of a supplement capable of relieving visual fatigue.
Background
Asthenopia, dry eye, foreign body sensation, heavy eyelid, blurred vision, photophobia, lacrimation, eye swelling and pain, hyperemia of eyes, etc. caused by asthenopia, severe symptoms such as headache, dizziness, nausea, listlessness, attention deficit, memory loss, anorexia, soreness of neck, shoulder, waist and back, numbness of finger joints, etc. can cause dysphoria of mood, life quality reduction, and general health status reduction for a long time. Is an important factor influencing the psychology, physiology and health of people. At present, health-care food capable of relieving asthenopia on the market is not common and is mostly synthesized by chemical drugs.
The invention has natural components, and is an ideal and high-end health food for relieving visual fatigue.
Disclosure of Invention
In order to solve the problems, the invention provides a preparation method of the supplement capable of relieving the asthenopia, the soft capsule preparation is adopted to effectively protect the easily oxidized components in the raw materials, the composition is scientific, the components are natural, the proportion is proper, the taste is good, the administration is convenient, and the supplement has the effects of supplying nutrient compositions required by eyes and delaying the oxidation.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the invention provides a preparation method of a supplement capable of relieving visual fatigue, which comprises the following steps:
s1, uniformly mixing 25-35 mg of natural lutein, 2-4mg of zeaxanthin, 2-4mg of astaxanthin, 500mg of schizochytrium DHA 300-;
step S2, based on step S1, as gelatin: glycerol: water = 2: 1: 2, taking gelatin, fully expanding, adding glycerol, heating, stirring to dissolve, standing and defoaming; filtering to remove impurities, mixing, maintaining the temperature of the glue solution at 55-65 deg.C, room temperature at 21-24 deg.C, and relative humidity at 40-45%, and keeping the product C;
and step S3, shaping the spare objects A, B and C by an automatic rotary pill making machine, drying, picking up pills, polishing with paraffin, and packaging to obtain the finished product.
Preferably, in step S1, the components are calculated according to the following weight portions: 25 mg of natural lutein, 2mg of zeaxanthin, 2mg of astaxanthin, 300mg of schizochytrium DHA, 110mg of spirulina extract, 128ug of vitamin A, 11mg of vitamin E, 11.1mg of vitamin B and 21.1mg of vitamin B.
Preferably, in step S1, the components are calculated according to the following weight portions: 30mg of natural lutein, 3mg of zeaxanthin, 3mg of astaxanthin, 400mg of schizochytrium DHA, 120mg of spirulina extract, vitamin A129ug, 12mg of vitamin E, 11.2mg of vitamin B and 21.2mg of vitamin B.
Preferably, in step S1, the natural lutein is 35 mg, the zeaxanthin is 4mg, the astaxanthin is 4mg, the schizochytrium DHA is 500mg, the spirulina extract is 130mg, the vitamin a is 130ug, the vitamin E13mg, the vitamin b 11.3mg, and the vitamin b 21.3mg.
Preferably, the method further comprises the following tablet preparation steps:
weighing 0.8g of lemon yellow, and dissolving in 120ml of distilled water;
adding 100g of gelatin, soaking overnight, fully dissolving in warm water, adding glycerol and sorbitol, and stirring to dissolve to obtain a solution A;
adding high amylopectin starch into the solution A, stirring and dispersing, fully mixing, and performing ultrasonic exhaust to obtain a solution B;
adding the finished product of the step S3 into the solution B, stirring, spreading on a plastic plate, drying at 25-30 ℃, and cutting to obtain tablets.
Preferably, the method further comprises step S4:
putting 150 g of D-sorbitol solution, 50 g of glycerol and 100g of proper amount of purified water into a 1L beaker, and mixing to obtain a mixed solution;
after adding 50 g of high amylopectin to the mixture and mixing thoroughly, 100g of gelatin is added to the mixture with stirring, and the resulting mixture is heated in a water bath at about 60 ℃ to prepare a capsule shell.
Preferably, the method further comprises step S5:
and (3) putting the finished product in a capsule shell according to a proper proportion to prepare the soft capsule.
Preferably, in step S1, the ratio of linseed oil: beeswax =1: 1.
The technical scheme of the invention has the following beneficial technical effects:
the invention adopts soft capsule preparation or tablet to effectively protect the easily oxidized components in the raw materials, has scientific composition, natural components, proper proportion, good taste and convenient taking, has the effects of supplying nutrient composition required by eyes and delaying oxidation, and is an ideal and high-end health food for relieving asthenopia.
Drawings
FIG. 1 is a flow chart of the present invention;
FIG. 2 is a four-factor three-level investigation chart of the capsule shell formulation of the present invention;
FIG. 3 is an orthogonal experimental chart of the optimal formulation of the present invention;
FIG. 4 is a graph showing the results of the experiment of FIG. 3;
FIG. 5 is an experimental diagram of one embodiment;
FIG. 6 is a diagram of a supplement product formulation of the present invention;
FIG. 7 is a graph of the results of an orthogonal test according to an embodiment of the present invention.
Detailed Description
In order to make the technical means, the original characteristics, the achieved purposes and the effects of the invention easily understood, the invention is further described below with reference to the specific embodiments and the attached drawings, but the following embodiments are only the preferred embodiments of the invention, and not all embodiments. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
Example 1
The invention provides a preparation method of a supplement capable of relieving visual fatigue, which comprises the following components in parts by weight: the adhesive comprises the following components in parts by weight: 25 mg of natural lutein, 2mg of zeaxanthin, 2mg of astaxanthin, 300mg of schizochytrium DHA, 110mg of spirulina extract, 128ug of vitamin A, 11mg of vitamin E, 11.1mg of vitamin B and 21.1mg of vitamin B; also comprises the following steps:
step S1, uniformly mixing the components according to the proportion for later use, putting 80g of linseed oil and 1g of beeswax in a proper amount into a 1L vacuum stirring barrel, heating to 70-80 ℃, dissolving, stirring and uniformly mixing for later use; linseed oil: beeswax =80: 1.
Step S2, based on step S1, as gelatin: glycerol: water = 2: 1: 2, taking gelatin, fully expanding, adding glycerol, heating, stirring to dissolve, standing and defoaming; filtering to remove impurities, mixing, maintaining the temperature of the glue solution at 55-65 deg.C, room temperature at 21-24 deg.C, and relative humidity at 40-45%;
and step S3, shaping by adopting an automatic rotary pill making machine, drying, picking pills, polishing by paraffin, and packaging to obtain a finished product.
In this embodiment, the method further comprises a tablet preparation step:
weighing 0.8g of lemon yellow, and dissolving in 120ml of distilled water;
adding 100g of gelatin, soaking overnight, fully dissolving in warm water, adding glycerol and sorbitol, and stirring to dissolve to obtain a solution A;
adding high amylopectin starch into the solution A, stirring and dispersing, fully mixing, and performing ultrasonic exhaust to obtain a solution B;
adding the finished product of the step S3 into the solution B, stirring, spreading on a plastic plate, drying at 25-30 ℃, and cutting to obtain tablets.
In this example, 150 g of D-sorbitol solution, 50 g of glycerol and 100g of a proper amount of purified water were placed in a 1L beaker and mixed to obtain a mixed solution;
after adding 50 g of high amylopectin to the mixture and mixing thoroughly, 100g of gelatin is added to the mixture with stirring, and the resulting mixture is heated in a water bath at about 60 ℃ to prepare a capsule shell. And (3) putting the finished product in a capsule shell according to a proper proportion to prepare the soft capsule.
Screening an optimal formula of the capsule skin:
after preliminarily determining the ranges of the ratio of glycerol to gelatin, the ratio of water to gelatin and the addition amounts of sorbitol and high amylopectin by consulting the data, the optimization is further carried out by using an L9(34) orthogonal experimental design (figure 2), and the obtained optimal formula is verified.
Product formula screening, and the used main raw materials and the use basis are as follows:
(1) astaxanthin;
(2) lutein/zeaxanthin;
（3）DHA；
(4) a vitamin;
(5) spirulina extract.
The optimal proportion of the formula of the capsule shell is as follows: as can be seen from the results of the orthogonal test and the range analysis in FIG. 3, the factor affecting the dissolution rate of the gelatin skin is glycerol/gelatin in turn>Water/gelatin>Sorbitol addition amount>The addition amount of the high amylopectin starch and the optimal formula of the soft capsule shell are A2B2C2D3。
Since the A2B3C3 combination was not found in the orthogonal test, a verification test was required. The gel was prepared according to formulation A2B3C3 and the dissolution rate of the gel was measured. The results are shown in FIG. 4.
As can be seen from FIG. 4, the verification test is closer to the prediction result, which indicates that the fitting condition of the test is better and the error of the test is small. Therefore, the analysis method meets the experimental requirements and can be used as a formula for optimizing the capsule shell. Thus, formulation A2B2C2D3, i.e. glycerol: gelatin is 0.5: 1; water: gelatin is 0.8: 1; the using amount of the sorbitol is 30 percent; the dosage of the high amylopectin is 10 percent, which is the best formula of the soft capsule shell.
In this embodiment, the method further comprises the preparation of a soft capsule:
adding gelatin, glycerol and water at a proper ratio into a gelatin barrel, heating to a proper sol temperature, stirring, vacuumizing by a vacuum pump to defoam and degas the gelatin solution, vacuumizing by the vacuum pump to defoam and degas the gelatin solution, observing the condition of the gelatin solution, filtering by a filter screen, placing into the gelatin barrel, keeping the temperature, standing, filling materials, pressing into capsules, and drying to obtain the soft capsule.
According to the result of the single-factor experiment, the optimal prescription of the content of the lutein soft capsule is optimized by adopting an orthogonal design experiment L9(34) by taking the dosage ratio (A) of the medicine and the linseed oil, the dosage (B) of the beewax and the dosage (C) of the soybean phospholipid as investigation factors. The factor level table is shown in FIG. 5:
wherein the dosage ratio is medicinal powder: a dispersion medium.
The suspension was placed in a dry centrifuge tube and height H recorded after shaking0Then, the height H of the sedimentation surface was measured at 6000rpm for 5min in a centrifuge, and the sedimentation volume ratio was calculated to be F = H/H0。
Example 2
The difference from example 1 is:
30mg of natural lutein, 3mg of zeaxanthin, 3mg of astaxanthin, 400mg of Schizotochloropsis DHA, 120mg of spirulina extract, 129ug of vitamin A, 12mg of vitamin E, 11.2mg of vitamin B and 21.2mg of vitamin B.
Example 3
The difference from example 1 is:
35 mg of natural lutein, 4mg of zeaxanthin, 4mg of astaxanthin, 500mg of schizochytrium DHA, 130mg of spirulina extract, 130ug of vitamin A, 13mg of vitamin E, 11.3mg of vitamin B and 21.3mg of vitamin B.
In the above examples, the supplement product formulation is shown in figure 6. The results of the orthogonal test are shown in FIG. 7.
Referring to fig. 7, it can be known from the visual analysis and the analysis of variance that, when the sedimentation ratio is used as the inspection index, the influence on the sedimentation ratio is sequentially the dosage ratio of the drug to the linseed oil > the dosage of the beeswax > the dosage of the soybean lecithin, and the optimal process is A1B1C3, namely, the powder: medicinal flaxseed: beeswax: soybean phospholipids = 15: 80: 1: 4.
the foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (8)

1. A preparation method of a supplement capable of relieving visual fatigue is characterized by comprising the following steps:
s1, uniformly mixing 25-35 mg of natural lutein, 2-4mg of zeaxanthin, 2-4mg of astaxanthin, 500mg of schizochytrium DHA 300-; step S2, based on step S1, as gelatin: glycerol: water = 2: 1: 2, taking gelatin, fully expanding, adding glycerol, heating, stirring to dissolve, standing and defoaming; filtering to remove impurities, mixing, maintaining the temperature of the glue solution at 55-65 deg.C, room temperature at 21-24 deg.C, and relative humidity at 40-45%, and keeping the product C; and step S3, shaping the spare objects A, B and C by an automatic rotary pill making machine, drying, picking up pills, polishing with paraffin, and packaging to obtain the finished product.
2. The method for preparing a supplement capable of relieving visual fatigue according to claim 1, wherein in the step S1, the following components are calculated according to parts by weight: 25 mg of natural lutein, 2mg of zeaxanthin, 2mg of astaxanthin, 300mg of schizochytrium DHA, 110mg of spirulina extract, 128ug of vitamin A, 11mg of vitamin E, 11.1mg of vitamin B and 21.1mg of vitamin B.
3. The method for preparing a supplement capable of relieving visual fatigue according to claim 1, wherein in the step S1, the following components are calculated according to parts by weight: 30mg of natural lutein, 3mg of zeaxanthin, 3mg of astaxanthin, 400mg of schizochytrium DHA, 120mg of spirulina extract, vitamin A129ug, 12mg of vitamin E, 11.2mg of vitamin B and 21.2mg of vitamin B.
4. The method of claim 1, wherein in step S1, the supplement comprises lutein 35 mg, zeaxanthin 4mg, astaxanthin 4mg, Schizochytrium sp DHA 500mg, Spirulina extract 130mg, vitamin A130 ug, vitamin E13mg, vitamin B11.3mg, and vitamin B21.3mg.
5. The method for preparing a supplement for relieving asthenopia according to claim 1, further comprising the steps of: weighing 0.8g of lemon yellow, and dissolving in 120ml of distilled water; adding 100g of gelatin, soaking overnight, fully dissolving in warm water, adding glycerol and sorbitol, and stirring to dissolve to obtain a solution A; adding high amylopectin starch into the solution A, stirring and dispersing, fully mixing, and performing ultrasonic exhaust to obtain a solution B;
adding the finished product of the step S3 into the solution B, stirring, spreading on a plastic plate, drying at 25-30 ℃, and cutting to obtain tablets.
6. The method for preparing a supplement for relieving asthenopia according to claim 1, further comprising step S4: putting 150 g of D-sorbitol solution, 50 g of glycerol and 100g of proper amount of purified water into a 1L beaker, and mixing to obtain a mixed solution; after adding 50 g of high amylopectin to the mixture and mixing thoroughly, 100g of gelatin is added to the mixture with stirring, and the resulting mixture is heated in a water bath at about 60 ℃ to prepare a capsule shell.
7. The method for preparing a supplement for relieving asthenopia according to claim 6, further comprising step S5: and (3) putting the finished product in a capsule shell according to a proper proportion to prepare the soft capsule.
8. The method for preparing a supplement for alleviating asthenopia according to claim 1, wherein in step S1, the weight ratio of linseed oil: beeswax =1: 1.
CN202210239756.6A 2022-03-12 2022-03-12 Preparation method of supplement capable of relieving asthenopia Pending CN114586979A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102150860A (en) * 2010-12-28 2011-08-17 北京同仁堂健康药业股份有限公司 Composition for easing visual fatigue and assisting in improving memory
CN104474018A (en) * 2014-12-22 2015-04-01 威海百合生物技术股份有限公司 Health-care soft capsule for relieving asthenopia
CN104839688A (en) * 2015-04-20 2015-08-19 华北制药秦皇岛有限公司 Eye care preparation and preparation method thereof
CN105053900A (en) * 2015-07-17 2015-11-18 瑞昌市渝瑞实业有限公司 Instant Chinese yam chips and preparation method thereof
CN111227251A (en) * 2020-03-04 2020-06-05 延寿县鼎鑫生物工程有限公司 Soft capsule containing sea-buckthorn seed oil, spirulina and vitamin E and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102150860A (en) * 2010-12-28 2011-08-17 北京同仁堂健康药业股份有限公司 Composition for easing visual fatigue and assisting in improving memory
CN104474018A (en) * 2014-12-22 2015-04-01 威海百合生物技术股份有限公司 Health-care soft capsule for relieving asthenopia
CN104839688A (en) * 2015-04-20 2015-08-19 华北制药秦皇岛有限公司 Eye care preparation and preparation method thereof
CN105053900A (en) * 2015-07-17 2015-11-18 瑞昌市渝瑞实业有限公司 Instant Chinese yam chips and preparation method thereof
CN111227251A (en) * 2020-03-04 2020-06-05 延寿县鼎鑫生物工程有限公司 Soft capsule containing sea-buckthorn seed oil, spirulina and vitamin E and preparation method thereof

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