CN106360782B - A kind of nutrition cellulose soft capsules dietary supplements for having the function of to prevent and repairing haze damage and preparation method thereof - Google Patents
A kind of nutrition cellulose soft capsules dietary supplements for having the function of to prevent and repairing haze damage and preparation method thereof Download PDFInfo
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- CN106360782B CN106360782B CN201610719922.7A CN201610719922A CN106360782B CN 106360782 B CN106360782 B CN 106360782B CN 201610719922 A CN201610719922 A CN 201610719922A CN 106360782 B CN106360782 B CN 106360782B
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- 229920002678 cellulose Polymers 0.000 title claims abstract description 16
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 16
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 32
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- 238000000034 method Methods 0.000 claims abstract description 12
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 22
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- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 11
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 229940046009 vitamin E Drugs 0.000 claims description 11
- 229930003316 Vitamin D Natural products 0.000 claims description 9
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 9
- 238000007872 degassing Methods 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 229940083466 soybean lecithin Drugs 0.000 claims description 9
- 239000011710 vitamin D Substances 0.000 claims description 9
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- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 8
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 7
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 7
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- 239000000463 material Substances 0.000 claims description 7
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 7
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- 241001465754 Metazoa Species 0.000 claims description 2
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- 238000000227 grinding Methods 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
A kind of nutrition cellulose soft capsules dietary supplements for having the function of to prevent and repairing haze damage and preparation method thereof, belongs to health-care food processing technique field.It includes capsule and the content in capsule；The capsule raw material is glue, and it is 50 ︰, 20 30 ︰, 50 ︰ 12 to form as Ming Jiao ︰ Gan You ︰ Chun Jing Shui ︰ titanium dioxide mass ratioes；In the content, containing 5 20 μ g vitamin Ds in every 500mg contents, 10 100mg vitamin Es, 5 15mg bata-carotenes, 10mg soybean lecithins, remaining is olive oil and/or fish oil.Inventive formulation is reasonable, preparation method is easy, rich in a variety of high-efficiency antioxidant nutrients, meet human body it is daily needed on the basis of, fully supplement the various active materials for having and intervening haze damage and anti-oxidation function, it effectively can prevent and improve the respiratory tract response to oxidative stress of haze pollutant initiation, so as to which the reactive oxygen species generated be avoided further to cause various inflammation even angiocardiopathy and cancer with body reaction.
Description
Technical field
The present invention relates to it is a kind of have the function of prevent and repair haze damage nutrition cellulose soft capsules dietary supplements and its
Preparation method belongs to health-care food processing technique field.
Background technology
In recent years, China's haze pollution occurs again and again, pollution range continuous enlargement, and the number by haze pollution effect is continuous
Increase.Although relevant departments have taken up measure and administer haze pollution, long the time required to being administered due to haze, regulation effect is not
It can get instant result, haze pollution in a short time will not mitigate, and people will continue to breathe contaminated air.Internal authority research institution
Have confirmed that air pollutants, especially PM2.5 particulate matters can cause the oxidative stress of human body, so as to cause various respiratory tracts
With skin disease such as respiratory tract infection, asthma, bronchitis etc..Severe patient even influences cardiovascular health as blood is hindered to follow
Ring causes angina pectoris, myocardial infarction, heart failure etc..The service life can be influenced by being exposed to the serious environment of air pollution for a long time.Therefore
It needs to adopt an effective measure prevention and repair haze to damage caused by human body.
At present, some authoritative research institutions are looked forward in Environmental Health in the world（Environment Health
Perspective）With U.S.'s breathing and critical care medicine magazine（American Journal of Respiratory and
Critical Care Medicine）It publishes thesis Deng profession research magazine, it is indicated that the various nutrients of meal supplement can be passed through
Fish oil and olive oil, vitamin D, vitamin E and beta carotene such as rich in polyunsaturated fatty acid can effectively mitigate mist
Haze damages.Environmental Protection Agency is research shows that the edible food rich in omega-3 polyunsaturated fatty acids can alleviate air pollution to people
Damage caused by body.Omega-3 polyunsaturated fatty acids pass through the reactive oxygen species with being generated by the stimulation of haze particle（ROS）Reaction, subtracts
Few adverse reactions of the ROS to human body cell, so as to reduce haze damage.Clinical trial also confirms that, insatiable hunger more than the ω -3 in fish oil
Superoxide dismutase in serum can be improved with aliphatic acid（SOD）With glutathione sulfydryl transferase level, aoxidized so as to mitigate
Damage caused by stress reaction.Other one of the administration is research shows that olive oil also has the function of to mitigate haze damage.This is
Since olive oil is rich in various vitamins and antioxidant, excellent antioxidant activity helps to improve endothelial function, reduces
Blood pressure caused by haze particulate matter increases.London King's College is the study found that suck experimenter's lung of more haze particle
Content of vitamin E in portion and blood is less, and indirect proof vitamin E plays the role of mitigating haze damage in human body.Its
He also confirms that in some researchs, the inflammatory reaction of vascular endothelial cell and oxidative stress caused by vitamin E can mitigate haze.Its
His antioxidant such as beta carotene also has stronger inoxidizability, and long-term consumption helps to enhance what body damaged haze
Resistance and repair ability.Since haze pollution can also influence vitamin D level in human body indirectly, the additionally supplement dimension life from food
Plain D is very necessary for maintaining the health by haze pollution crowd.In conclusion various nutrition can be supplemented by strengthening
It is known as effect prevention and mitigates damage of the haze to human body.
Due to eating habit difference, may not be met needed for pre- haze by the nutrient of food intake for each person every day.Cause
This, the present invention develops a kind of dietary supplements rich in a variety of anti-fog haze nutrients, is simply and effectively provided to human body various anti-
Haze active material.The present invention selects anti-fog haze activity and the stronger fat soluble nutrient of antioxidant activity, to be rich in more insatiable hungers
With the fish oil and/or olive oil of aliphatic acid mixing soft capsule is prepared for matrix.Produced mixotrophism cellulose soft capsules are rich in a variety of
Active ingredient is easily digested, and bioavailability is high.This product formula is reasonable, is meeting needed for normal body
On the basis of, a large amount of anti-fog haze nutrients are provided, to prevent and mitigate everyday air pollution injury caused by human body.Meanwhile
In some ingredients also have and improve immune system function, improve health, pre- anti-cancer and all kinds of angiocardiopathies of prevention
Effect.The content of various nutrients is less than aceptable daily intake (ADI) as defined in the Ministry of Public Health（ADI）, it is ensured that the safety of product.At present
On the market without the mixotrophism element product of pre- haze damage, the present invention will fill up this blank.
Invention content
The purpose of the present invention is mitigating haze pollution damage caused by health, a kind of component science, prevention are provided
The compound nutritional cellulose soft capsules dietary supplements notable, convenient with haze damage effect is improved.
Technical scheme of the present invention, a kind of nutrition cellulose soft capsules meal supplement for having the function of to prevent and repair haze damage
Agent, the content including capsule and in capsule；The capsule raw material is glue, is formed as Ming Jiao ︰ Gan You ︰ Chun Jing Shui ︰
Titanium dioxide mass ratio is 50 ︰ 20-30 ︰, 50 ︰ 1-2；In the content, contain 5-20 μ g vitamin Ds in every 500mg contents,
10-100mg vitamin Es, 5-15mg beta carotenes, 10mg soybean lecithins, remaining is olive oil and/or fish oil, every glue
Intracapsular content is 500 ± 50mg.
It is described per 500mg contents in containing 5-10 μ g vitamin Ds, 10-20mg vitamin Es, 5-10mg beta carotenes,
10mg soybean lecithins, remaining is olive oil or fish oil.
It is described per 500mg contents in containing 5-10 μ g vitamin Ds, 10-20mg vitamin Es, 5-10mg beta carotenes,
10mg soybean lecithins, remaining is the mass mixings objects such as olive oil and fish oil.
The gelatin is animal gelatin.The titanium dioxide is edible rank titanium dioxide.The olive oil is extra virgin olive
Olive oil.The soybean lecithin is the concentrated soybean phospholipid of 60% content of phospholipid.
DHA and EPA content are no less than the 50% of fish oil gross mass in the fish oil.
The preparation method of the nutrition cellulose soft capsules dietary supplements for having the function of to prevent and repairing haze damage, by weight
It is as follows to measure part meter step：
（1）It is prepared by glue：Prepare to make the glue of capsule, glue material therefor is 50 parts of gelatin, glycerine 20-30
Part, 1-2 parts of 50 parts of pure water and titanium dioxide；1-2 parts of titanium dioxides are mixed with 10 parts of glycerine first, grinding 25-35min is made mixed
Suspension is closed, 50 parts of pure water and remaining 10-20 parts of glycerine is added in, stirs evenly；50 parts of gelatin particles are added in, are heated to
65-70 DEG C, stirring 15-25min is complete to dissolving；With 100 mesh screens under heat-retaining condition, vacuumize, vacuum degree≤-
0.08MPa, degassing are spare；
（2）The preparation of content：It is made of by every 500mg contents following nutrient：5-20 μ g vitamin Ds, 10-
100mg vitamin Es, 5-15mg beta carotenes, 10mg soybean lecithins, remaining is olive oil and/or fish oil；First by fish oil
And/or olive oil is mixed with soybean lecithin, is sufficiently stirred, and vitamin D, vitamin E and β-Hu are added in said mixture
Radish element, stirring 60min are fully dissolved, are vacuumized.Vacuum degree≤- 0.08MPa, degassing are for use；
（3）The preparation of soft capsule：By step（1）Prepare gained glue and step（2）Gained content is prepared in capsule machine
On through pelleting soft capsule is made；Wherein 60-65 DEG C of glue box temperature, every soft capsule contain 500 ± 50 mg contents；
（4）Post processing：By step（3）The soft capsule being pressed into is placed in rotating cage shape dry 3h, setting temperature 22-25
DEG C, humidity 35%-45%；Qualitative dried capsule is then placed in drying room drying 36h, 28-31 DEG C of drying temperature, humidity
25%-35%；Gained capsule is carried out to select ball, failure is removed, is packed with lighttight container, obtaining product has in advance
Nutrition cellulose soft capsules dietary supplements that is anti-and repairing haze damage function.
Beneficial effects of the present invention：Formula provided by the invention is reasonable, rich in a variety of high-efficiency antioxidant nutrients, is meeting
On the basis of needed for human body is daily, the various active materials for having and intervening haze damage and anti-oxidation function are fully supplemented, it can
The respiratory tract response to oxidative stress that effectively prevention and improvement haze pollutant cause, so as to avoid the reactive oxygen species generated further
Cause various inflammation even angiocardiopathy and cancer with body reaction.
Specific embodiment
The present invention, including but not limited to following Examples are illustrated by following instance.
Embodiment 1
（1）It is prepared by glue：Glue material therefor and ratio are that Ming Jiao ︰ Gan You ︰ Chun Jing Shui ︰ titanium dioxides weight ratio is 50 ︰
20 ︰, 50 ︰ 1 mix 1 part of titanium dioxide with 10 parts of glycerine, grind and mixing suspension is made, and add in 50 parts of pure water and remaining 10 parts
Glycerine stirs evenly.Add in gelatin particle（50 parts）, it is heated to 65 DEG C.Stirring is complete to dissolving（About 25min）, heat preservation filtering,
It is spare after degassing；
（2）The preparation of content：It is made of per 500mg contents following nutrient：5 μ g vitamin Ds, 10mg vitamins
E, 5mg bata-carotene, 10mg soybean lecithins, remaining is olive oil.Configuration method is as follows：By olive oil and soybean lecithin
Mixing, is sufficiently stirred.Vitamin D, vitamin E, beta carotene are added in said mixture, stirring 60min fully dissolves,
Degassing is for use；
（3）The preparation of soft capsule：Soft capsule is made through pelleting on capsule machine with content in glue.Glue box temperature 60 C,
Every soft capsule content containing 500mg；
（4）Post processing：The soft capsule being pressed into, which is placed in rotating cage, shapes（22 DEG C of temperature, humidity 40% ± 5%）Dry 3h.It puts
In drying room（28 DEG C of temperature, humidity 30% ± 5%）Dry 36h.Again through selecting ball, failure is removed.With lighttight container into
Row packaging.
Embodiment 2：
（1）It is prepared by glue：Glue material therefor and ratio are that Ming Jiao ︰ Gan You ︰ Chun Jing Shui ︰ titanium dioxides weight ratio is 50 ︰
20 ︰, 50 ︰ 1 mix 1 part of titanium dioxide with 10 parts of glycerine, grind and mixing suspension is made, and add in 50 parts of pure water and remaining 10 parts
Glycerine stirs evenly.Add in gelatin particle（50 parts）, it is heated to 70 DEG C.Stirring is complete to dissolving（About 25min）, heat preservation filtering,
It is spare after degassing.
（2）The preparation of content：It is made of per 500mg contents following nutrient：10 μ g vitamin Ds, 20mg vitamins
E, 10mg bata-carotene, 10mg soybean lecithins, remaining is olive oil.Configuration method is as follows：By olive oil and soybean lecithin
Mixing, is sufficiently stirred.Vitamin D, vitamin E, beta carotene are added in said mixture, stirring 60min fully dissolves,
Degassing is for use.
（3）The preparation of soft capsule：Soft capsule is made through pelleting on capsule machine with content in glue.Glue box temperature 60-65
DEG C, every soft capsule content containing 500mg.
（4）Post processing：The soft capsule being pressed into, which is placed in rotating cage, shapes（25 DEG C of temperature, humidity 40% ± 5%）Dry 3h.
It is placed in drying room（31 DEG C of temperature, humidity 30% ± 5%）Dry 36h.Again through selecting ball, failure is removed.With lighttight container
It is packed.
Embodiment 3
（1）It is prepared by glue：Glue material therefor and ratio are that Ming Jiao ︰ Gan You ︰ Chun Jing Shui ︰ titanium dioxides mass ratio is 50 ︰
20 ︰, 50 ︰ 1 mix 1 part of titanium dioxide with 10 parts of glycerine, grind and mixing suspension is made, and add in pure water and remaining 10 parts sweet
Oil stirs evenly.Add in gelatin particle（50 parts）, it is heated to 68 DEG C.Stirring is complete to dissolving（About 25min）, heat preservation is filtered, de-
It is spare after gas.
（2）The preparation of content：It is made of per 500mg contents following nutrient：5 μ g vitamin Ds, 10mg vitamins
E, 5mg bata-carotene, 10mg soybean lecithins, remaining is fish oil.Configuration method is as follows：Fish oil is mixed with soybean lecithin,
It is sufficiently stirred.Vitamin D, vitamin E, beta carotene are added in said mixture, stirring 60min fully dissolves, and degassing is treated
With.
（3）The preparation of soft capsule：Soft capsule is made through pelleting on capsule machine with content in glue.Glue box temperature 60-65
DEG C, every soft capsule content containing 500mg.
（4）Post processing：The soft capsule being pressed into, which is placed in rotating cage, shapes（23 DEG C of temperature, humidity 40% ± 5%）Dry 3h.It puts
In drying room（30 DEG C of temperature, humidity 30% ± 5%）Dry 36h.Again through selecting ball, failure is removed.With lighttight container into
Row packaging.
Embodiment 4
（1）It is prepared by glue：Glue material therefor and ratio are that Ming Jiao ︰ Gan You ︰ Chun Jing Shui ︰ titanium dioxides mass ratio is 50 ︰
20 ︰, 50 ︰ 1 mix 1 part of titanium dioxide with 10 parts of glycerine, grind and mixing suspension is made, and add in pure water and remaining 10 parts sweet
Oil stirs evenly.Add in gelatin particle（50 parts）, it is heated to 66 DEG C.Stirring is complete to dissolving（About 25min）, heat preservation is filtered, de-
It is spare after gas.
（2）The preparation of content：It is made of per 500mg contents following nutrient：10 μ g vitamin Ds, 20mg vitamins
E, 10mg bata-carotene, 10mg soybean lecithins, remaining is fish oil.Configuration method is as follows：Fish oil and soybean lecithin are mixed
It closes, is sufficiently stirred.Vitamin D, vitamin E, beta carotene are added in said mixture, stirring 60min is fully dissolved, taken off
Gas is for use.
（3）The preparation of soft capsule：Soft capsule is made through pelleting on capsule machine with content in glue.63 DEG C of glue box temperature,
Every soft capsule content containing 500mg.
（4）Post processing：The soft capsule being pressed into, which is placed in rotating cage, shapes（24 DEG C of temperature, humidity 40% ± 5%）Dry 3h.It puts
In drying room（31 DEG C of temperature, humidity 30% ± 5%）Dry 36h.Again through selecting ball, failure is removed.With lighttight container into
Row packaging.
Embodiment 5：
（1）It is prepared by glue：Glue material therefor and ratio are that Ming Jiao ︰ Gan You ︰ Chun Jing Shui ︰ titanium dioxides mass ratio is 50 ︰
20 ︰, 50 ︰ 2 mix 2 parts of titanium dioxides with 10 parts of glycerine, grind and mixing suspension is made, and add in pure water and remaining 10 parts sweet
Oil stirs evenly.Add in gelatin particle（50 parts）, it is heated to 65 DEG C.Stirring is complete to dissolving（About 25min）, heat preservation is filtered, de-
It is spare after gas.
（2）The preparation of content：It is made of per 500mg contents following nutrient：10 μ g vitamin Ds, 20mg vitamins
E, 10mg bata-carotene, 10mg soybean lecithins, remaining is the mass mixings objects such as olive oil and fish oil.Configuration method is as follows：It will
Fish oil and olive oil are mixed with soybean lecithin, are sufficiently stirred.Vitamin D, vitamin E, β-Hu are added in said mixture
Radish element, stirring 60min fully dissolve, and degassing is for use.
（3）The preparation of soft capsule：Soft capsule is made through pelleting on capsule machine with content in glue.Glue box temperature 60-65
DEG C, every soft capsule content containing 500mg.
（4）Post processing：The soft capsule being pressed into, which is placed in rotating cage, shapes（25 DEG C of temperature, humidity 40% ± 5%）Dry 3h.It puts
In drying room（28 DEG C of temperature, humidity 30% ± 5%）Dry 36h.Again through selecting ball, failure is removed.With lighttight container into
Row packaging.
Claims (6)
1. a kind of preparation method for the nutrition cellulose soft capsules dietary supplements for having the function of to prevent and repairing haze damage, feature
It is that step is as follows by weight：
（1）It is prepared by glue：Prepare the glue for making capsule, glue material therefor is 50 parts of gelatin, and 20-30 parts of glycerine is pure
1-2 parts of 50 parts of water purification and titanium dioxide；1-2 parts of titanium dioxides are mixed with 10 parts of glycerine first, it is outstanding that mixing is made in grinding 25-35min
Supernatant liquid adds in 50 parts of pure water and remaining 10-20 parts of glycerine, stirs evenly；50 parts of gelatin particles are added in, are heated to 65-70
DEG C, stirring 15-25min is complete to dissolving；It with 100 mesh screens under heat-retaining condition, vacuumizes, vacuum degree≤- 0.08MPa, takes off
Gas is spare；
（2）The preparation of content：It is made of by every 500mg contents following nutrient：5-20 μ g vitamin Ds, 10-100mg dimensions
Raw element E, 5-15mg beta carotenes, 10mg soybean lecithins, remaining is olive oil and/or fish oil；First by fish oil and/or olive
Olive oil is mixed with soybean lecithin, is sufficiently stirred, and vitamin D, vitamin E and beta carotene are added in said mixture, is stirred
It mixes 60min fully to dissolve, vacuumize, vacuum degree≤- 0.08MPa, degassing is for use；
（3）The preparation of soft capsule：By step（1）Prepare gained glue and step（2）Gained content is prepared to pass through on capsule machine
Soft capsule is made in pelleting；Wherein the glue box temperature of capsule machine is 60-65 DEG C, every soft capsule content containing 500 ± 50mg；
（4）Post processing：By step（3）The soft capsule being pressed into is placed in rotating cage the dry 3h that shapes, and 22-25 DEG C of setting temperature is wet
Spend 35%-45%；The dried capsule that will then shape is placed in drying room drying 36h, 28-31 DEG C of drying temperature, humidity 25%-
35%；Gained capsule is carried out to select ball, failure is removed, is packed with lighttight container, obtain that there is prevention and is repaired
Haze damages the nutrition cellulose soft capsules dietary supplements of function.
2. there is the preparation for preventing and repairing the nutrition cellulose soft capsules dietary supplements that haze damages as described in claim 1
Method, it is characterised in that：The gelatin is animal gelatin.
3. there is the preparation for preventing and repairing the nutrition cellulose soft capsules dietary supplements that haze damages as described in claim 1
Method, it is characterised in that：The titanium dioxide is edible rank titanium dioxide.
4. there is the preparation for preventing and repairing the nutrition cellulose soft capsules dietary supplements that haze damages as described in claim 1
Method, it is characterised in that：The olive oil is Extra Virgin.
5. there is the preparation for preventing and repairing the nutrition cellulose soft capsules dietary supplements that haze damages as described in claim 1
Method, it is characterised in that：The soybean lecithin is the concentrated soybean phospholipid of 60% content of phospholipid.
6. there is the preparation for preventing and repairing the nutrition cellulose soft capsules dietary supplements that haze damages as described in claim 1
Method, it is characterised in that：DHA and EPA content are no less than the 50% of fish oil gross mass in the fish oil.
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| CN201610719922.7A CN106360782B (en) | 2016-08-25 | 2016-08-25 | A kind of nutrition cellulose soft capsules dietary supplements for having the function of to prevent and repairing haze damage and preparation method thereof |
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| CN107279976A (en) * | 2017-07-01 | 2017-10-24 | 山东健康源生物工程有限公司 | A kind of natural VE adds bata-carotene soft capsule and preparation method thereof |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5876709A (en) * | 1997-05-26 | 1999-03-02 | New Vision Co., Ltd. | Ophthalmic composition containing active Vitamin D |
| CN1568803A (en) * | 2004-04-30 | 2005-01-26 | 南阳市海达生物技术有限公司 | Food with blood-sugar/blood-fat reducing function and preparation method thereof |
| CN1660420A (en) * | 2005-01-06 | 2005-08-31 | 昆明圣火制药有限责任公司 | Compound combination of Chinese traditional medicine in use for lowering viscosity of whole blood, thrombolysis and reducing blood fat |
| CN101695377A (en) * | 2009-09-14 | 2010-04-21 | 蔡晓东 | Soya bean lecithin soft capsule |
| CN103181565A (en) * | 2013-03-07 | 2013-07-03 | 苟春虎 | PM2.5-preventing capsule for clearing away lung toxicant and protecting lungs |
| CN103251060A (en) * | 2013-04-17 | 2013-08-21 | 苟春虎 | Dust-haze prevention lung heat clearing capsule |
| CN103893240A (en) * | 2014-04-24 | 2014-07-02 | 山东福田药业有限公司 | Composition for preventing and/or treating respiratory system diseases caused by hazes |
| CN104095182A (en) * | 2014-06-16 | 2014-10-15 | 李卫平 | Food with protection effect on lung injury caused by fog and haze |
| CN104623170A (en) * | 2015-01-07 | 2015-05-20 | 苟春虎 | Anti-haze lung-protecting buccal tablet |
| CN105287430A (en) * | 2015-12-01 | 2016-02-03 | 广州市富诺生物科技有限公司 | Algae oil soft capsule and preparation method thereof |
| CN105533505A (en) * | 2016-02-25 | 2016-05-04 | 山东禹王制药有限公司 | Chewing-type compound fish oil soft capsules and preparation method thereof |
| CN105595323A (en) * | 2015-12-02 | 2016-05-25 | 北京世纪合辉医药科技股份有限公司 | Phosphatide-unsaturated fatty acid compound health product and preparation method thereof |
-
2016
- 2016-08-25 CN CN201610719922.7A patent/CN106360782B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5876709A (en) * | 1997-05-26 | 1999-03-02 | New Vision Co., Ltd. | Ophthalmic composition containing active Vitamin D |
| CN1568803A (en) * | 2004-04-30 | 2005-01-26 | 南阳市海达生物技术有限公司 | Food with blood-sugar/blood-fat reducing function and preparation method thereof |
| CN1660420A (en) * | 2005-01-06 | 2005-08-31 | 昆明圣火制药有限责任公司 | Compound combination of Chinese traditional medicine in use for lowering viscosity of whole blood, thrombolysis and reducing blood fat |
| CN101695377A (en) * | 2009-09-14 | 2010-04-21 | 蔡晓东 | Soya bean lecithin soft capsule |
| CN103181565A (en) * | 2013-03-07 | 2013-07-03 | 苟春虎 | PM2.5-preventing capsule for clearing away lung toxicant and protecting lungs |
| CN103251060A (en) * | 2013-04-17 | 2013-08-21 | 苟春虎 | Dust-haze prevention lung heat clearing capsule |
| CN103893240A (en) * | 2014-04-24 | 2014-07-02 | 山东福田药业有限公司 | Composition for preventing and/or treating respiratory system diseases caused by hazes |
| CN104095182A (en) * | 2014-06-16 | 2014-10-15 | 李卫平 | Food with protection effect on lung injury caused by fog and haze |
| CN104623170A (en) * | 2015-01-07 | 2015-05-20 | 苟春虎 | Anti-haze lung-protecting buccal tablet |
| CN105287430A (en) * | 2015-12-01 | 2016-02-03 | 广州市富诺生物科技有限公司 | Algae oil soft capsule and preparation method thereof |
| CN105595323A (en) * | 2015-12-02 | 2016-05-25 | 北京世纪合辉医药科技股份有限公司 | Phosphatide-unsaturated fatty acid compound health product and preparation method thereof |
| CN105533505A (en) * | 2016-02-25 | 2016-05-04 | 山东禹王制药有限公司 | Chewing-type compound fish oil soft capsules and preparation method thereof |
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| CN106360782A (en) | 2017-02-01 |
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