CN1660420A - Compound combination of Chinese traditional medicine in use for lowering viscosity of whole blood, thrombolysis and reducing blood fat - Google Patents
Compound combination of Chinese traditional medicine in use for lowering viscosity of whole blood, thrombolysis and reducing blood fat Download PDFInfo
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- CN1660420A CN1660420A CN 200510000062 CN200510000062A CN1660420A CN 1660420 A CN1660420 A CN 1660420A CN 200510000062 CN200510000062 CN 200510000062 CN 200510000062 A CN200510000062 A CN 200510000062A CN 1660420 A CN1660420 A CN 1660420A
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- lumbrukinase
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- radix notoginseng
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- tea polyphenols
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Abstract
A Chinese medicine for decreasing blood viscosity and blood fat and dissolving thrombus contains arasaponin, earthworm kinase and theapolyphenol.
Description
Technical field
The invention belongs to medical technical field, being specifically related to a kind of is that raw material is used to Chinese traditional compound medicine that reduces whole blood viscosity, thrombolytic, blood fat reducing and preparation method thereof with Radix Notoginseng total arasaponins, Lumbrukinase, tea polyphenols etc.
Background technology
Cardiovascular and cerebrovascular disease is the main disease of current harm humans health, and the trend that rises is arranged year by year, becomes the serious disease that disability rate, mortality rate rank first place.Continuous rising along with living standard, now, not only in developed country, in some industrialized countries and many developing countries, cardiovascular and cerebrovascular disease become the human life's " first executioner ", according to statistics, the sickness rate of the cardiovascular disease of China rises year by year, and the number that cardiovascular and cerebrovascular disease is died from the whole nation every year has exceeded 1,000,000.And, the disease in various degree of existence per capita of all ages and classes section, hemorheologys etc. occur unusual, blood fat is higher, blood viscosity increases, platelet aggregation or absorption, and then form serious symptoms such as atherosclerosis, thrombosis, coronary heart disease, myocardial infarction, cerebral infarction.At present, treat this disease both at home and abroad and roughly use following medicine: as the anti-anginal drug nitroglycerin, efonidipine, nifedipine etc.; Lipid regulating agent nicotinic acid, fibric acid; Antioxidant probucols etc., thrombolytic medicine streptokinase (SK), urokinase (UK), Statins medicine etc., but the equal tool serious adverse reaction of above-mentioned medicine, life-time service or dosage are crossed conference and are caused other tissue organ function of human body to take place unusually.Disturbance of blood circulation medication XUESAITONG series of products through clinical use for many years, long-term physiochemical indice safety is better than above product, but because clinical scope is wider, the curative effect specificity is not outstanding, slightly be inferior to the Statins medicine aspect blood viscosity lowering, logical bolt ability also is in weak tendency, therefore, develop a kind of safe, medicine of blood viscosity lowering efficiently, very urgent.
Radix Notoginseng is the distinctive valuable ingredient of Chinese medicine in Yunnan Province, and the beginning is stated from Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, have the title of " the refreshing medicine of hemostasis, the quality goods for the treatment of blood disorders ".In recent decades, the modern medicine scholar has carried out a large amount of systematic researches to the main active ingredient Radix Notoginseng total arasaponins of Radix Notoginseng, proves that Radix Notoginseng total arasaponins resists myocardial ischemia, there is good effect antithrombotic formation, antiplatelet aggregation and aspects such as atherosclerosis, blood viscosity lowering.Tea polyphenols be develop in recent years by the natural materials that extracts in the Folium Camelliae sinensis, have lipoid peroxidization resistant, blood viscosity lowering, blood fat reducing, the prevention effect on hyperlipemia.Lumbrukinase be develop in recent years by the protein that extracts in the extraordinary Lumbricus with plasmin activity, no matter intravenous injection or oral administration all have thrombolytic effect, being has one of fibrinolytic medicine of DEVELOPMENT PROSPECT at present most.
Summary of the invention
Based on above-mentioned, the present invention makes up effective ingredient arasaponin, Lumbrukinase, tea polyphenols in the Radix Notoginseng in proportion, make a kind of new medicine compound that is used for the treatment of cardiovascular and cerebrovascular disease, no matter be aspect reduction whole blood viscosity, thrombolytic, blood fat reducing, all the therapeutic effect than existing commercially available prod all improves a lot, and safety simultaneously is also more remarkable than present commercially available prod.
The invention provides the preparation method of component composition and the weight proportion and the said composition preparation of said composition, also disclose a kind of purposes of said composition.
The present invention is achieved through the following technical solutions:
The component prescription is: Radix Notoginseng total arasaponins 10-300 weight portion, Lumbrukinase 10-300 weight portion and/or tea polyphenols 10-300 weight portion;
With above-mentioned raw materials by its weight proportion more in addition pharmaceutic adjuvant make soft capsule, hard capsule, tablet, granule;
The preparation of soft capsule: Radix Notoginseng total arasaponins, Lumbrukinase and/or tea polyphenols are mixed, add adjuvant, mixing, colloid mill grinds, and makes medicinal liquid; With gelatin, glycerol, distilled water, food coloring and antiseptic are made glue; Medicinal liquid and glue are made soft capsule by encapsulating machine, and drying obtains soft capsule; Wherein the soft capsule adjuvant is one or more in safflower oil, Oleum Arachidis hypogaeae semen, soybean oil, refined oil, Oleum Perillae, Polyethylene Glycol, the linolenic acid, and softgel shell is gelatin, glycerol, food coloring, antiseptic, distilled water; Food coloring is a kind of in cocoa pigment, brown iron oxide, lemon yellow, sunset yellow, the titanium dioxide, and antiseptic is a kind of in methyl hydroxybenzoate, ethyl ester, the sodium benzoate.
The preparation of granule: Radix Notoginseng total arasaponins, Lumbrukinase and/or tea polyphenols are mixed, add dextrin, sucrose is made granule.
The preparation of hard capsule: Radix Notoginseng total arasaponins, Lumbrukinase and/or tea polyphenols are mixed, be filled to hard capsule by the hard capsule filling machine.
The preparation of tablet: Radix Notoginseng total arasaponins, Lumbrukinase and/or tea polyphenols are mixed, add starch and medicinal alcohol, make granule, be pressed into tablet by tablet machine.
Pharmacodynamic experiment:
The curative effect of reduction whole blood viscosity, thrombolytic and the treatment cardiovascular and cerebrovascular disease of product of the present invention is described below by experimental data:
Method one: rat is divided into 3 groups at random, 10 every group.Normal group, the conventional raising; High fat group gives normal diet+high fat (4% cholesterol, 10% Adeps Sus domestica, 0.2% propylthiouracil, the plain sodium of 0.5% gallbladder); The treatment group, normal diet+high fat+medicine (arasaponin+Lumbrukinase) is raised, and continuous 14 days, eyeball excise was got blood, measured following index:
Remarks rheology influence (n=10)
| Group | Whole blood viscosity | Plasma viscosity | PBC hematocrit (%) | Fibrinogen (g%) | ||
| The low 20S that cuts -1 | In cut 60S -1 | Height is cut 80S -1 | ||||
| Normal group | ??7.32±0.68 | ???6.46±0.42 | ??5.24±1.01 | ??1.67±0.04 | ??48.46±0.69 | ??0.19±0.04 |
| High fat group | ??14.68±3.02 | ???10.05±1.80 | ??7.08±0.77 | ??1.94±0.07 | ??4.90±059 | ??0.22±0.06 |
| The treatment group | ??8.62±0.81 | ???7.53±1.87 | ??5.51±1.22 | ??1.81±0.06 | ??47.5±1.17 | ??0.19±0.01 |
The variation of blood fat (n=10, mmol/L)
| Group | ????TG | ????TC | ????HDL-C | ????LDL-C |
| Normal group | ??0.39±0.02 | ??3.77±0.48 | ??1.47±0.1 | ??2.45±0.39 |
| High fat group | ??0.67±0.13 | ??7.15±1.36 | ??1.23±0.12 | ??5.19±0.39 |
| The treatment group | ??0.41±0.04 | ??4.08±0.64 | ??1.49±0.23 | ??2.89±0.53 |
Method two: 30 Carnis Coturnicis japonicaes are divided into 3 groups by sex and body weight, and 10 every group, the normal control group gives normal diet and feeds; High fat matched group gives normal diet and increases 3 weeks of fat forage feed; The treatment group, after hyperlipemia forms, the medicine of feeding (arasaponin+Lumbrukinase+tea polyphenols).Result such as following table:
| Group | ????TG | ????TC | ????HDL-C | ????LDL-C |
| Normal group | ??1.83±0.55 | ??5.06±0.86 | ??3.34±0.56 | ??1.52±0.14 |
| High fat group | ??12.96±0.43 | ??9.88±2.51 | ??2.71±0.24 | ??3.79±1.5 |
| The treatment group | ??4.76±1.30 | ??5.99±1.55 | ??3.09±0.56 | ??1.66±0.59 |
Above result as can be seen, the compound recipe XUESAITONG RUANJIAONANG has the prevention hyperlipemia, blood viscosity lowering and improve the effect of hemorheological property has comparatively wide application prospect, is worth further research and development.
The specific embodiment:
Embodiment 1
Radix Notoginseng total arasaponins 60g Lumbrukinase 50g tea polyphenols 100g
Safflower oil 240g gelatin 220g glycerol 90g
Ethyl hydroxybenzoate 0.1g distilled water 250g cocoa pigment 50mg
Above supplementary material is made 1000 soft capsules
Method for making: with Radix Notoginseng total arasaponins, Lumbrukinase, tea polyphenols and Flos Carthami seed oil mixing, use colloid mill ground and mixed 30 minutes, emit standby; Gelatin and distilled water mixing, 40-50 ℃ of heating for dissolving is warmed up to 70 ℃, adds pigment and antiseptic, stirs 30 minutes, in 0.08Mpa vacuum evacuation 30 minutes, cools to 40-50 ℃, is incubated 2-4 hour, and be standby; The medicinal liquid and the glue that prepare are pressed into soft capsule by the soft capsule unit, drying, useless ball is removed in choosing, ethanol flush away capsule surface lubricating oil, drying, packing obtains finished product.
Embodiment 2
Radix Notoginseng total arasaponins 60g Lumbrukinase 40g Oleum Arachidis hypogaeae semen soybean oil 50g
Gelatin 150g glycerol 60g ethyl hydroxybenzoate 0.06g distilled water 180g
Lemon yellow pigment 50mg
Above supplementary material is made 1000 soft capsules
Method for making: with Radix Notoginseng total arasaponins, Lumbrukinase and Oleum Arachidis hypogaeae semen mixing, use colloid mill ground and mixed 30 minutes, emit standby; Gelatin and distilled water mixing, 40-50 ℃ of heating for dissolving is warmed up to 70 ℃, adds pigment and antiseptic, stirs 30 minutes, in 0.08Mpa vacuum evacuation 30 minutes, cools to 40-50 ℃, is incubated 2-4 hour, and be standby; The medicinal liquid and the glue that prepare are pressed into soft capsule by the soft capsule unit, drying, useless ball is removed in choosing, ethanol flush away capsule surface lubricating oil, drying, packing obtains finished product.
Embodiment 3
Radix Notoginseng total arasaponins 100g tea polyphenols 100g refined oil 200g linolenic acid 100g
Gelatin 250g glycerol 100g ethyl hydroxybenzoate 0.15g
Distilled water 300g sunset yellow 80mg
Above supplementary material is made 1000 soft capsules
Method for making: with Radix Notoginseng total arasaponins, tea polyphenols and refined oil mixing, use colloid mill ground and mixed 30 minutes, emit standby; Gelatin and distilled water mixing, 40-50 ℃ of heating for dissolving is warmed up to 70 ℃, adds pigment and antiseptic, stirs 30 minutes, in 0.08Mpa vacuum evacuation 30 minutes, cools to 40-50 ℃, is incubated 2-4 hour, and be standby; The medicinal liquid and the glue that prepare are pressed into soft capsule by the soft capsule unit, drying, useless ball is removed in choosing, ethanol flush away capsule surface lubricating oil, drying, packing obtains finished product.
Embodiment 4
Lumbrukinase 100g tea polyphenols 60g safflower oil 200g
Gelatin 200g glycerol 80g ethyl hydroxybenzoate 0.1g
Distilled water 220g cocoa pigment 50mg
Above supplementary material is made 1000 soft capsules
Method for making: with Lumbrukinase, tea polyphenols and Flos Carthami seed oil mixing, use colloid mill ground and mixed 30 minutes, emit standby; Gelatin and distilled water mixing, 40-50 ℃ of heating for dissolving is warmed up to 70 ℃, adds pigment and antiseptic, stirs 30 minutes, in 0.08Mpa vacuum evacuation 30 minutes, cools to 40-50 ℃, is incubated 2-4 hour, and be standby; The medicinal liquid and the glue that prepare are pressed into soft capsule by the soft capsule unit, drying, useless ball is removed in choosing, ethanol flush away capsule surface lubricating oil, drying, packing obtains finished product.
Embodiment 5
Radix Notoginseng total arasaponins 250g Lumbrukinase 50g safflower oil 350g
Gelatin 250g glycerol 100g ethyl hydroxybenzoate 0.2g
Distilled water 280g cocoa pigment 50mg
Above supplementary material is made 1000 soft capsules
Method for making: with Radix Notoginseng total arasaponins, Lumbrukinase and Flos Carthami seed oil mixing, use colloid mill ground and mixed 30 minutes, emit standby; Gelatin and distilled water mixing, 40-50 ℃ of heating for dissolving is warmed up to 70 ℃, adds pigment and antiseptic, stirs 30 minutes, in 0.08Mpa vacuum evacuation 30 minutes, cools to 40-50 ℃, is incubated 2-4 hour, and be standby; The medicinal liquid and the glue that prepare are pressed into soft capsule by the soft capsule unit, drying, useless ball is removed in choosing, ethanol flush away capsule surface lubricating oil, drying, packing obtains finished product.
Embodiment 6
Radix Notoginseng total arasaponins 150g Lumbrukinase 100g tea polyphenols 200g
Above supplementary material is made 1000 hard capsules
Method for making: with Radix Notoginseng total arasaponins, Lumbrukinase, tea polyphenols mixing, make hard capsule by capsule filling machine, packing obtains finished product.
Embodiment 7
Radix Notoginseng total arasaponins 100g Lumbrukinase 50g tea polyphenols 100g starch 50g
Above supplementary material is pressed into 1000
Method for making: with Radix Notoginseng total arasaponins, Lumbrukinase, tea polyphenols mixing, add starch, make granule with small amount of ethanol, be pressed into the pressure agent with tablet machine, packing obtains finished product.
Embodiment 8
Radix Notoginseng total arasaponins 250g Lumbrukinase 100g tea polyphenols 200g dextrin 50g
Sucrose 400g
Above supplementary material is made granule 1000g
Method for making: with Radix Notoginseng total arasaponins, Lumbrukinase, tea polyphenols mixing, add dextrin, cane sugar powder, make granule with small amount of ethanol, drying, packing obtains finished product.
Claims (9)
1, a kind of herbal mixture compositions is characterized in that the effective ingredient of this medicine is made up of following components by part by weight: Radix Notoginseng total arasaponins 10-300 weight portion, Lumbrukinase 10-300 weight portion and/or tea polyphenols 10-300 weight portion.
2, herbal mixture compositions as claimed in claim 1 is characterized in that this medicine is soft capsule, hard capsule, tablet, granule.
3, as herbal mixture compositions as described in the claim 2, wherein the preparation method of soft capsule is: Radix Notoginseng total arasaponins, Lumbrukinase and/or tea polyphenols are mixed, add adjuvant, and mixing, colloid mill is made medicinal liquid after grinding; With gelatin, glycerol, distilled water, food coloring and antiseptic are made glue; Medicinal liquid and glue are made soft capsule by encapsulating machine, and drying obtains soft capsule.
4, herbal mixture compositions as claimed in claim 3, the soft capsule adjuvant is one or more in safflower oil, Oleum Arachidis hypogaeae semen, refined oil, Oleum Perillae, Polyethylene Glycol, linolenic acid, the soybean oil.
5, herbal mixture compositions as claimed in claim 3, wherein food coloring is a kind of in cocoa pigment, brown iron oxide, lemon yellow, sunset yellow, the titanium dioxide; Antiseptic is a kind of in methyl hydroxybenzoate, ethyl ester, the sodium benzoate.
6, as herbal mixture compositions as described in the claim 2, wherein the preparation method of granule is: Radix Notoginseng total arasaponins, Lumbrukinase and/or tea polyphenols are mixed, add dextrin, sucrose is made granule.
7, herbal mixture compositions as claimed in claim 2, wherein the preparation method of hard capsule is: Radix Notoginseng total arasaponins, Lumbrukinase, tea polyphenols are mixed, be filled to hard capsule by the hard capsule filling machine.
8, as herbal mixture compositions as described in the claim 2, wherein the preparation method of tablet is: Radix Notoginseng total arasaponins, Lumbrukinase and/or tea polyphenols are mixed, add starch and medicinal alcohol, make granule, be pressed into tablet by tablet machine.
9, as the application of each described herbal mixture compositions of claim 1-8 in the medicine of preparation treatment cardiovascular and cerebrovascular disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510000062 CN1660420A (en) | 2005-01-06 | 2005-01-06 | Compound combination of Chinese traditional medicine in use for lowering viscosity of whole blood, thrombolysis and reducing blood fat |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510000062 CN1660420A (en) | 2005-01-06 | 2005-01-06 | Compound combination of Chinese traditional medicine in use for lowering viscosity of whole blood, thrombolysis and reducing blood fat |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940314A (en) * | 2010-08-06 | 2011-01-12 | 陈森全 | Polyphenol health care capsule and preparation method thereof |
| CN102008598A (en) * | 2010-12-17 | 2011-04-13 | 深圳技师学院 | Blood fat-lowering and liver-protecting composite as well as preparation prepared thereby and preparation method of preparation |
| CN106360782A (en) * | 2016-08-25 | 2017-02-01 | 江南大学 | Nutrient soft capsule dietary supplement having functions of preventing and repairing haze damage and preparation method thereof |
| CN106619728A (en) * | 2015-10-28 | 2017-05-10 | 高努 | Extraction method of pheretima thrombolysis component |
-
2005
- 2005-01-06 CN CN 200510000062 patent/CN1660420A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940314A (en) * | 2010-08-06 | 2011-01-12 | 陈森全 | Polyphenol health care capsule and preparation method thereof |
| CN102008598A (en) * | 2010-12-17 | 2011-04-13 | 深圳技师学院 | Blood fat-lowering and liver-protecting composite as well as preparation prepared thereby and preparation method of preparation |
| CN102008598B (en) * | 2010-12-17 | 2013-04-24 | 深圳技师学院 | Blood fat-lowering and liver-protecting composite as well as preparation prepared thereby and preparation method of preparation |
| CN106619728A (en) * | 2015-10-28 | 2017-05-10 | 高努 | Extraction method of pheretima thrombolysis component |
| CN106360782A (en) * | 2016-08-25 | 2017-02-01 | 江南大学 | Nutrient soft capsule dietary supplement having functions of preventing and repairing haze damage and preparation method thereof |
| CN106360782B (en) * | 2016-08-25 | 2018-07-10 | 江南大学 | A kind of nutrition cellulose soft capsules dietary supplements for having the function of to prevent and repairing haze damage and preparation method thereof |
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