CN103404875A - Complex ocean special-diet food eaten by patients with cardiovascular disease - Google Patents
Complex ocean special-diet food eaten by patients with cardiovascular disease Download PDFInfo
- Publication number
- CN103404875A CN103404875A CN201310385262XA CN201310385262A CN103404875A CN 103404875 A CN103404875 A CN 103404875A CN 201310385262X A CN201310385262X A CN 201310385262XA CN 201310385262 A CN201310385262 A CN 201310385262A CN 103404875 A CN103404875 A CN 103404875A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- special dietary
- dietary seafood
- composite marine
- edible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses complex ocean special-diet food eaten by patients with cardiovascular disease. The complex ocean special-diet food comprises oligochitosan, astaxanthin, beta-carotene, allicin, coenzyme Q10, vitamin C, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B3, vitamin B6, folic acid, vitamin B12 and macroelements calcium and magnesium as well as microelements iron, zinc, copper, manganese, selenium and chromium. The complex ocean special-diet food is a novel and complete nutritional food, can be used for comprehensively improving the nutrition conditions of the patients with cardiovascular disease and enhancing the organism immunity of the patients with cardiovascular disease, is beneficial to protecting the normal functions of the heart and coronary artery through the combined action of the oligochitosan and other natural active ingredients, improving the symptoms of cardiovascular diseases and reducing the occurrence rate of coronary heart disease complications, and is suitable for being taken by the patients with cardiovascular disease for long time.
Description
Technical field
The invention belongs to nutritious health caring food technology field, relate to a kind of for the special dietary seafood of the edible composite marine of cardiovascular patient.
Background technology
Angiocardiopathy, be called again circulation system disease, a series of diseases that relate to the circulatory system, the circulatory system refers to hemophoric Organ and tissue in human body, mainly comprise heart, blood vessel (artery, vein, capilary), can be subdivided into acutely and chronic, be all generally relevant with artery sclerosis.Wherein, coronary cardiopathy is a kind of modal angiocardiopathy, be called for short coronary heart disease, be a kind of myocardial ischemia-anoxemia (angina pectoris) caused by coronary artery organic (atherosclerotic or dynamic property vasopasm) stenosis or occlusion or the heart disease of myocardial necrosis (miocardial infarction), also claim ischemic heart disease.Coronary heart disease human health with its high M & M serious threat, is " first killer " of harm humans life and health.Since the seventies in last century, along with rapid raising and the particularly quick change of dietary of life style of living standards of the people, the angiocardiopathies such as coronary heart disease rise year by year at the incidence of disease of China, and sicken age is tending towards rejuvenation.So the control form of the angiocardiopathy of China is very severe.
The pathogeny of coronary heart disease is still not clear so far, but the hazards of coronary heart disease are very clear and definite.At present medical circle generally believes, except heredity and age factor, most of hazards that affect incidence of coronary heart disease, comprise dyslipidemia, hypertension, diabetes, smoking, obesity, do not get enough athletic exercise and emotional factor etc., all can change.Have result of study to show, atherosclerotic is the Etiological of coronary heart disease, and LDL-C is to cause atherosclerotic root.
Coronary heart disease is one way of life mode disease, and dyslipidemia is relevant to diet.The diet of high heat, higher fatty acid, high cholesterol, high sugar, improve Incidence of CHD greatly.Therefore, meals are very important for controlling coronary heart disease and complication thereof.There are clear and definite regulation and perfect standard criterion in European and American developed countries to food of special nutrients, and for people, have generally accepted.China has worked out " Chinese residents dietary guidelines " at present, and this guide was revised in 2007, take " packing in advance food for special foods label general rule GB13432-2004 " be main regulatory documents.In this general rule, special diet is defined as: " for meeting the physiological requirements of some particular patients ', or the nutritional need of some Disease, press the food of the special processing of special formulation ".The science essence of particular patients ' diet regulation and control is: control regular diet, supplement special diet, strengthening, for nutrition, reduces the metabolism burden, promotes healthy.
At present, on China market, have for the edible food for special foods of patients with coronary heart disease, but great majority are all vitamin, mineral matter class and blood lipid-lowering medicine that some are simple, more or less all exist the irrational problem of composition, collocation and using dosage, so can not nurse one's health all sidedly the physiological function of cardiovascular patient, thereby be difficult to the effect that reaches desirable.In addition, in patent documentation, also can find to utilize the exploitation coronary heart disease health foods such as chitosan oligosaccharide, Co-Q10, marine polysaccharide, for example " sea dietary of a patent No. CN201010290775.9 patients with coronary heart disease special use ", but the formula content complexity of this patent, to actual production, bring inconvenience, and its formula effect is not through the zoopery checking.
Summary of the invention
For above-mentioned problems of the prior art, the present invention provides a kind of for the special dietary seafood of the edible composite marine of cardiovascular patient according to the deficiency of physilogical characteristics, nutritional need and the conventional meals thereof of cardiovascular patient, supplements for cardiovascular patient provides natural active matter and needed by human nutrient.Its chitosan oligosaccharide contained, astaxanthin, beta carotene, allicin, Co-Q10 and vitamin and mineral matter, can improve the nutrition condition of body patients with coronary heart disease, nurses one's health its physiological function comprehensively, plays the effect that improves immunity of organisms, improves symptom.
For achieving the above object, the present invention is achieved by the following technical solutions:
It is a kind of that its material composition content is as follows for the special dietary seafood of the edible composite marine of cardiovascular patient, in weight portion:
Further, the special dietary seafood of described composite marine also includes linseed oil 50-200 part.
Further, the special dietary seafood of described composite marine also includes extractive of flax seed 5-20 part.
Further, the special dietary seafood of described composite marine also includes sea cucumber polysaccharide 0.1-5 part, fucoidin sulfuric ester 20-300 part and L-carnitine-L-tartrate 8-30 part.
Further, the described chitosan oligosaccharide degree of polymerization is 2-15, and molecular weight is below 5000.
Further, the special dietary seafood of described composite marine is capsule, tablet, pulvis, granule, oral liquid or paste.
The present invention also provides described preparation method for the edible special dietary seafood of composite marine of cardiovascular patient, it comprises the following steps: choose above-mentioned each material composition, proportioning according to described weight portion adds above-mentioned material, after pulverizing and sieving, mixes; Control temperature at preparation this product content below 60 ℃, under the lucifuge condition, routine operation makes pulvis, granule or capsule, and all operations all carries out in the clean dried environment.
Described another kind of preparation method for the edible special dietary seafood of composite marine of cardiovascular patient, it comprises the following steps: choose above-mentioned each material composition, add above-mentioned material according to the proportioning of described weight portion, material is dropped into to the vacuum emulsification tank, stir, grind to obtain this product content; Gelatin, glycerine, purified water Hybrid Heating are stirred to gelatin and dissolve make softgel shell solution fully, vacuumize degassing, softgel shell solution is incubated to 55 ℃-60 ℃; Get foregoing thing and softgel shell solution, compressing, drying makes soft capsule.
Further, in vacuum, be under 0.08-0.09MPa, to vacuumize de-bubble to the greatest extent.
Compared with prior art, advantage of the present invention and technique effect are:
The present invention is the special dietary seafood of a kind of novel, comprehensive composite marine, can improve the physiological function of cardiovascular patient comprehensively, removes free radical, improves immunity.
The present invention combines multiple natural active matter and nutrient, carry out reasonably combined, can give full play to the unique effect of each composition, can play mutual promotion again, complement each other, complementary effect, play more perfect than single component, more comprehensively with powerful effect, reached the requirement of product safety, effective, quality controllable health products.
Chitosan oligosaccharide used in the present invention, astaxanthin, beta carotene, allicin and Co-Q10 are natural active materials, have excretion of cholesterol, reducing blood lipid, anti-oxidant, the effect that strengthens immunity of organisms; Vitamin in the invention and the nutrients such as mineral matter are except being the nutrient that generally lacks of China resident simultaneously, the effect that also has the physiological function that improves cardiovascular patient, their addition is with reference to Chinese residents Chinese DRIs every day, combination by active skull cap components and nutrient, the present invention is had to be incorporated multiple different efficacies composition in product, these compositions cooperatively interact, and synergy comprehensively, balancedly is the patients with coronary heart disease extra-nutrition.Therefore functional component and the materials safety of product are high, and long-term edible having no side effect, be the desirable nutrient supplement food of cardiovascular patient.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Be applicable to the special dietary seafood of the edible composite marine of cardiovascular patient, the content of its each material composition is:
The preparation method of the special dietary seafood of described composite marine comprises the following steps:
Get the degree of polymerization and be 2-15, molecular weight and be water-soluble chitosan oligosaccharide 500mg below 5000 and astaxanthin, beta carotene, allicin, Co-Q10, vitamin C, vitamin E, the vitamin D of above-mentioned formula ratio
3, Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
6, folic acid, Cobastab
12, calcium gluconae, zinc lactate, ferrous lactate, magnesium gluconate, manganese citrate, copper gluconate, selenocysteine, nicotinate chromium mix, after adding the 100mg linseed oil, grind with grinder, afterwards material is dropped into to the vacuum emulsification tank, stir, grind to obtain this product content by grinder.Gelatin, glycerine, purified water ratio in accordance with regulations is mixed and heated to certain temperature (75 ℃) to be stirred to gelatin and to dissolve fully, vacuumize degassing 30 minutes (vacuum 0.09MPa), get foregoing thing and softgel shell solution, with the soft capsule production equipment, adopt pressing compressing, after drying, namely obtain and be applicable to the special dietary seafood capsule of the edible composite marine of cardiovascular patient.
Below introduce in detail the characteristic of each material composition of the present invention:
Chitosan oligosaccharide: be a kind of completely new product that shitosan is obtained through special biological enzyme technology processing, its good water solubility, biologically active is high, and heat is low, and easily is absorbed by the body.The function of chitosan oligosaccharide is very powerful, has and improves blood pressure, hypoglycemic, the function that suppresses fat absorption, row's cholesterol, anti-trioxypurine value, re-scheduling metal ion, inhibition tumor cell, balance the body pH value, promotion wound healing, regulating intestinal canal and raising immunity.
Astaxanthin: being a kind of of carotenoid, is that the mankind find the antioxidant that nature is the strongest up to now, can ultraviolet radiation preventing; strengthen the human body energy metabolism, suppress tumour, suppress diabetes and ephrosis; protection retina and central nervous system, improve immunity.There are some researches show, astaxanthin has the increase HDL in vivo, alleviate the oxidation of density lipoprotein, alleviate the inflammatory reaction of macrophage, reduce the formation of AP, increase the stability of AP, reduce plaque rupture, improve the effect of blood flow, thereby play the effect of prevention and cure of cardiovascular disease.
Beta carotene: being a kind of fat-soluble antioxidant, is the approach of current safest replenishing vitamins A.Research both at home and abroad shows, beta carotene not only can be hypotensive, hypoglycemic, reducing blood lipid, beauty treatment, defaecation and anti-ageing, also has and improves immunologic function, PFT, the upper respiratory tract is anti-infective and suppresses the ability of tumor growth.Particularly for cardiovascular health, beta carotene can be prevented and treated obstructive atherosclerotic formation, angiocardiopathy preventing.
Allicin: be a kind ofly to take garlic bulb and be the extract of raw material, have hypoglycemic, reducing blood lipid, anti-ageing, anti-oxidant, sterilization, anti-inflammatory and strengthen the effect such as body immunity.It can be by reducing hyperglycemia state that blood sugar alleviates diabetes to cardiovascular infringement, by reducing serum total cholesterol, suppress biologically active pdgf, reduce blood viscosity, hypotensive etc. be used for protecting cardiovascular health.
Co-Q10: be a kind of fat-soluble antioxidant, it is one of indispensable important element of human life, its can human activin cell and the nutrition of cellular energy, has the body immunity of raising, strengthens anti-oxidant, antitumor, anti-hypertension, delays senility and strengthen the function such as human activity.The non-oxidizability of Co-Q10 makes it in atherosclerotic formation and development process, have certain inhibitory action, and it has remarkable result aspect allevating angina pectoris, the Co-Q10 of proper content is essential for suitable muscle function, help, for cardiac muscle provides sufficient oxygen, can prevent sudden heart disease.
Linseed oil: be a kind of oils that is rich in alpha-linolenic acid of being squeezed by linseed, wherein the content of alpha-linolenic acid is 55%.Alpha-linolenic acid is essential fatty acid, can not synthesize in human body, must be from external picked-up.It mainly comprises the following aspects to the protective effect of health: by excretion and the inhibition endogenous cholesterol that increases cholesterol, synthesize to reduce serum cholesterol, regulate blood fat comprehensively; By reducing blood viscosity, increasing the blood oxygen carrying content and prevent that thrombosis from preventing miocardial infarction; Promote simultaneously insulin in blood, to remain stable, stabilizing blood sugar, reduce hypertension and normal arterial pressure is unaffected, protection each organ of human body and nervous system.
Extractive of flax seed (commercially available): main active is flax lignan class material.Flax lignan can alleviate various skin problems, consumption health superabundant fats, improves women's premenstrual syndrome, promotes health compressive resistance ability, improves arthritis, reduce cholesterol, atherosclerosis.Flax lignan not only has prevention effect to breast cancer, prostate cancer, menstrual period syndrome, osteoporosis, also to diabetes, stomach and intestine tumor, coronary heart disease, kidney trouble, and the effect that non-oxidizability is useful.
Sea cucumber polysaccharide: be mainly glycosaminoglycan extracted from sea cucumber or mucopolysaccharide, be present in wall of sea cucumber Stichopus japonicus corium connective tissue, body cavity, interior glandular tube and internal organ, have enhanced machine body immunity function, anticoagulation, antithrombotic, reducing blood lipid, prevention of arterial is atherosis, antitumor, the physiological active functions such as delay senility.
Fucoidin sulfuric ester: claim again fucoidin, algal polysaccharide sulfate, it is peculiar marine active polysaccharide in brown algae sea-plant (sea-tangle etc.), at occurring in nature, belong to rare sulfuric ester ionic natural polysaccharide, through great many of experiments and clinical research, show to have the immunity of raising, hypoglycemic, anticoagulation, reducing blood lipid, hypotensive, inhibition renal failure, the physiologically active such as antitumor.
L-carnitine-L-tartrate: l-cn is the necessary auxiliary substance of a kind of body fat oxidative metabolism.Due to content in food is low and body in synthetic quantity less, l-cn lacks, and can produce hyperglycaemia, high fat of blood, angiocardiopathy, fatty liver, male sterility and weak symptom etc.As a kind of nutritional supplement of promotion oxidative cleavage of fatty acids of safe, effective, science, l-cn can reduce body fat, reduces body weight; Reduce serum total cholesterol and triglycerides, the rising serum high-density LP; Strengthen the ability of cardiac muscle cell's oxidation of fat, the burden of heart while reducing high-intensity exercise; Improve cardiac arrhythmia and don't affect blood pressure; Improve immune function of human body, the enhanced machine vitality of subject, fatigue-relieving, delay senility.L-carnitine-L-tartrate is a kind of stable form of l-cn, is difficult for the moisture absorption, easily preserves, and has and the identical effect of l-cn, and human body is had no side effect.
Vitamin C: be a kind of water soluble vitamin, for guarantee human body metabolic normally carry out with the raising of immunologic function most important.It can not only treat scurvy and hypoferric anemia, and prevention gingival atrophy and hemorrhage promotes the normal synthetic of collagen, also can promote the excretion of cholesterol, prevent that cholesterol from depositing at Wall of Artery, the atheromatous plaque deposited is dissolved, thus the generation of prevention and control coronary heart disease.In addition, ascorbic antioxidation can be resisted the injury of radical pair cell, improves body immunity.
Vitamin D: be a kind of liposoluble vitamin, be mainly used in forming and maintaining the strong of bone, and immune system is had to humidification.The D that is deficient in vitamin is harmful to life and health, may cause as various diseases such as coronary heart disease.Therefore for patients with coronary heart disease, it is very necessary supplementing appropriate vitamin D.Vitamin D can reduce the tolerance to insulin, and insulin resistance is to cause one of cardiopathic principal element.
Vitamin E: being a kind of liposoluble vitamin, claiming again tocopherol, is one of topmost antioxidant, can stop the infringement of radical pair vascular wall.Tocopherol can promote sex hormone secretion, and man's sperm motility and quantity are increased; Make woman's female hormone Enrichment, improve fecundity, prevention of miscarriage.In addition, vitamin E is a kind of very important vasodilator and anticoagulant, prevention and treatment varication, and solidifying of anti-Hemostatic Oral Liquid, reduce the generation of speckle tissue; Improve blood circulation, protective tissue, reduction cholesterol, preventing hypertension; Improve lipid-metabolism, prevention of arterial is atherosis and coronary heart disease.
Cobastab
1: claim again thiamine or antineuritic vitamin or anti beriberi vitamin, it is not only human energy metabolism, and particularly glycometabolism is necessary, still maintains heart, and nerve and digestive system normal function are necessary.Its physiological function comprises the promotion growth, helps digest; Improve mental status; Maintain the normal of nerve fiber, muscle, cardiomotility.
Cobastab
2: be again riboflavin, its physiological function comprises: participate in human body affecting biological oxidation and energetic supersession, and relevant with the metabolism of carbohydrate, protein, nucleic acid and fat; Participating in the growth metabolism of cell, is the necessary nutrient of injected organism tissue metabolism and reparation; Relevant with absorption, storage and the mobilization of body iron; Has antioxidation biology activity etc.
Cobastab
3: claim nicotinic acid, it does not still maintain the vitamin of digestive system health yet, is the synthetic indispensable material of sex hormone, is the cells activated by insulin agent yet, helps to prevent and treat diabetes.Concerning life was full of the modern of pressure, nicotinic acid maintained the effect of the healthy and brain function normal operation of nervous system, can ignore anything but.In addition, it can reduce cholesterol and triglyceride, stimulates circulation, and makes blood pressure drops, has stronger expansion peripheral vessels effect.
Cobastab
6: be body fat and glycometabolic essential material, help atherosclerotic control.Have experiment to show, homovitamin B6 intake reduces the incidence of disease of myocardial infarction and lethal coronary heart disease, thereby angiocardiopathy is played to prevention effect.It is also very close with the relation of vitamin B2, and Vitamin B6 deficiency is often with the vitamin B2 symptom.
Folic acid: be a kind of of B family vitamin, coordinate Cobastab
6And B
12, increasing of prevention homocysteine level, can improve function of vascular endothelium, angiocardiopathy preventing.
Cobastab
12: main Physiological Function is to participate in manufacturing erythrocyte, prevents pernicious anaemia; Safeguard nervous system health; Form with coenzyme exists, and can increase the utilization rate of folic acid, promotes the metabolism of carbohydrate, fat and protein; Fat metabolism acid, make fat, carbohydrate, protein suitably be used by health.
Calcium: be a kind of inorganic salts that people's in-vivo content is maximum, it maintains the normal physiological state of all cells, as normally beating of heart; Calcium and magnesium, potassium, sodium plasma keep certain proportion, make nerve, muscle keep normal reaction; The calcium tool regulates the rhythm of the heart, reduce cardiovascular permeability, control inflammation and oedema, maintain the effect such as acid-base balance.
Magnesium: be the indispensable element that maintains the human life activity, have and regulate the magical function that N&M is movable, strengthen endurance.In addition, magnesium is also " jinx " of hypertension, high cholesterol, hyperglycaemia, helps to prevent and treat apoplexy, coronary heart disease and diabetes.
Iron: be the essential trace element of human body, iron is to the present many aspects of the menu of human body, and iron participates in transportation and the storage of oxygen.These have the heart, liver, kidney in the cell mitochondrial of height physiological activity ability and biochemical function, and the iron of storage is many especially, and mitochondria is cell " energy factory ", and iron is participated in the release of energy directly.Iron can also promote to grow; The resistance of increase to disease; Regulate tissue respiration, prevent fatigue; Form ferroheme, the anaemia that prevention and treatment cause because of iron deficiency; Make skin recover good color.
Zinc: be the trace element of needed by human, but can not synthesize in vivo, can only rely on external food to provide.It is the constituent of the many important enzymes of human body, is also the necessary element of insulin synthesis; It synthesizes, safeguards erythrocytic integrality and all play an important role in hematopoiesis protein and nucleic acid, is the key element of enhancing development; It also can improve body immunity.
Copper: be the indispensable micronutrient of health, for blood, nervous centralis and immune system, growth and the function of hair, skin and skeletal tissue and brain and the internal organ such as liver, the heart have material impact.Calcareous and Lipid Plaque on copper degradable blood vessel wall, strengthen the function that connects the cardiac myocyte fibr tissue, improve the connection of collagen, be conducive to the firm of arterial wall, make heart and blood vessel keep normal morphology and function, thereby reach the purpose of effective prevention and Cardiovarscular.
Manganese: it is relevant with the human body different physiological roles, comprises the normal growth and the growth that affect bone, affects sugared metabolism, must be indispensable in maintaining the normal brain activity function.
Selenium: selenium and vitamin E are all antioxidants, and the two complements each other, and the speed of its variation that can prevent from can slowing down because of aging that oxidation causes, the hardening of tissue, at least, have activated immune system, the cardiovascular and antineoplastic effect of protection; Can regulate glycometabolism, help the diabetic to control blood sugar, be necessary trace mineral.Selenium also has detoxicating functions, because selenium and metal have good compatibility.
Chromium: be one of trace element in body, its content in vivo reduces gradually along with the increase at age.Though the requirement of chromium is few, can help insulin to promote that glucose enters intracellular efficiency, be important blood sugar regulator.It helps to grow, and the cholesterol concentration in blood is also had to control action, formation that can atherosclerosis, but the able person causes heart disease during shortage.Therefore, take in right amount chromium, important effect is particularly arranged for diabetic and cardiovascular patient.
The emphasis difference of the various functional components in the present invention, various components have been combined together synergistic function, aspect prevention and cure of cardiovascular disease and complication thereof, can obtain than the better effect of single component use.
Chitosan oligosaccharide is a kind of natural alkaline polysaccharide, a kind ofly be with cationic natural polymer animal origin, it can control agent in acid-base balance, the activation erythrocyte, purify the blood, bidirectional modulation blood pressure, blood fat, the alleviating vascular smooth muscle spasm, softening artery, recover blood vessel elasticity, repair damaged vascular wall, thereby play the effect of prevention and cure of cardiovascular disease.The effect that chitosan oligosaccharide is mainly realized regulating cholesterol, lowered blood fat by following approach: first, by affecting bile acid, aliphatic acid and inhibition cholesterol enzyme, regulate and control conversion, the absorption and synthetic of cholesterol, the cholesterol in blood is down to and normally is unlikely to too low poised state; The second, by suppressing the lipolytic activity of pancreatic lipase, thereby reduce the hydrolysis of fat in enteron aisle, and then reduce fat absorption in vivo; The 3rd, chitosan oligosaccharide can form cation group after dissolving, and can be gathered in vivo around electronegative oil droplet, hinders fat absorption, and the fat of adsorption band anion also excretes, and reduces body fat and gathers.In addition, chitosan oligosaccharide can activate erythrocyte, changes intra-erythrocyte pressure reduction, removes its gathering, improves its oxygen therapy and exchange capacity; Positively charged chitosan oligosaccharide is combined and excretes with electronegative chlorion, can activate the blood pressure vascular cell, improves microcirculation, reduces peripheral vascular resistance, reduce the deposition of lipid at vascular wall, thereby realize regulating the effect of blood pressure.Therefore, what chitosan oligosaccharide stressed to emphasize is directly for the adjusting of blood fat, blood pressure, to play a positive role, and effect is more direct.
Astaxanthin is that the mankind find the antioxidant that nature is the strongest up to now, energy singlet-oxygen quenching and removing peroxylradicals; This effect outclass other carotenoid and vitamin E, can inhibitory mutagenesis, Cell differentiation inducing activity, anti-oxidant, have the plurality of health care functions such as the free radical of removing, Cell protection, enhancing immunization, anti-inflammatory, angiocardiopathy preventing and cancer.Especially, the astaxanthin astaxanthin has the increase HDL in vivo, alleviates the oxidation of low-density lipoprotein, alleviate the inflammatory reaction of macrophage, reduce the formation of AP, increase the stability of AP, reduce plaque rupture, improve the effect of blood flow.Therefore choose chitosan oligosaccharide and the astaxanthin main component for the special dietary seafood of this composite marine.
Composite composition as chitosan oligosaccharide and astaxanthin, beta carotene, allicin, Co-Q10, linseed oil, extractive of flax seed, sea cucumber polysaccharide, fucoidin sulfuric ester, various vitamin and mineral matter have similar effect on a lot of functions: the effect of anti-oxidant, repair cell, balance the body sugar and lipid metabolism, reduce blood fat, blood sugar, improve blood pressure, strengthen immunologic function, fatigue-relieving etc.In the present invention, these composite compositions and main component are superimposed and mutually promote, mutually supplement, and can play complementary " monarch " effect.Wherein, chitosan oligosaccharide and astaxanthin are " monarchs drug in a prescription ", in the special dietary seafood of this composite marine, prevention and cure of cardiovascular disease are played a major role, indispensable; Other composite compositions, or auxiliary " monarch drug in a prescription " stiffening effect, or work for double disease, or improve on the whole the physical condition of cardiovascular patient.Its effect is better than any single component or alone main component.
The interpolation form of mineral matter of the present invention is the organic or inorganic compound of this mineral matter.
In the present invention, the addition of vitamin and minerals is carried out with reference to " DRIs " of Chinese Soclety of Nutrition's promulgation in 2000, " nutrient prime replenisher is declared and evaluated regulation (trying) " middle " vitamin, mineral types and consumption " of stipulating that " food enrichment use sanitary standard " on July 1st, (GB14880-1994) He 2005, State Food and Drug Administration formally came into effect.
Prepared by the present invention can be made into the various ways such as capsule, tablet, pulvis, granule, oral liquid, paste for the special dietary seafood of the edible composite marine of cardiovascular patient.
Embodiment 2
Be applicable to the special dietary seafood of the edible composite marine of cardiovascular patient, the content of its each material composition is:
The preparation method of the special dietary seafood of described composite marine comprises the following steps:
Get purity and be 20%～60% flax lignan 15mg, sea cucumber polysaccharide 5mg that molecular weight is 4-5 ten thousand and chitosan oligosaccharide, astaxanthin, beta carotene, allicin, Co-Q10, fucoidin sulfuric ester, L-carnitine-L-tartrate, vitamin C, vitamin E, cholecalciferol, the Cobastab of above-mentioned formula ratio
1, Cobastab
2, Cobastab
3, Cobastab
6, folic acid, Cobastab
12, calcium gluconae, zinc lactate, ferrous lactate, magnesium gluconate, manganese citrate, copper gluconate, selenocysteine, nicotinate chromium mix; Add first forward in mixer to be dry mixed stirring the above-mentioned raw material mixed, 10% dextrin starch slurry can be divided to count several times in mixer and carry out wet mixing and close, continuous stirring, make softwood; Getting above-mentioned softwood sends in oscillating granulator and granulates with 16 eye mesh screens; The particle made is put into to baking oven dry, moisture when following, can stop drying 3%, gives free rein to dry in the air cool; Then cross 14 eye mesh screens and carry out whole grain, make the single-size shape this product that meets the requirements big or small.
Embodiment 3, implementation result experiment
With the special dietary seafood of the edible composite marine of cardiovascular patient that is applicable in embodiment 2, implement mouse experiment.
Adopt high lipid food nursing male ApoE in 4 age in week
-/-Mouse, set up atherosclerotic (AS) model, 4 the week age male ApoE
-/-100 of mouse are divided into 5 groups at random: (1) model group; (2) rosuvastain calcium (5mg/kg/d) group; (3) chitosan oligosaccharide absorption group (20mg/kg/d); (4) this product standard absorption group (25mg/kg/d); (5) the collaborative absorption group of this product (25mg/kg/d) and rosuvastain calcium (5mg/kg/d), implementation method are gavage after distilled water diluting.Meanwhile get 4 age in week 20 of male C57BL/6J wild-type mices as Normal group.After high lipid food fed for 12 weeks, put to death mouse, collect serum, use enzymic colorimetric to measure TC, TG in serum, use direct measuring method to measure Serum HDL-C, LDL-C.Take out mouse aorta, with FFPE, row aorta root serial section, after application haematoxylin-Yi red colouring (HE dyeing), the histological characteristic of observation mouse atherosclerotic (AS) plate and plaque area (PA), vessel lumen area (LA), the plaque area of calculation correction is than (PA/LA).
Table 1 is respectively organized Comparison of experiment results
Table 1 experimental result shows:
1, the ApoE of high lipid food nursing
-/-Mouse is compared its aortic root of wild type and has formed obvious atherosclerotic, and the patch volume increases.
2, only adding experimental mice serum TC, the LDL-C of this product to compare its concentration of model group group all has decline in various degree, and plaque area also has remarkable reduction difference to have conspicuousness (P<0.05) than (PA/LA); Absorption chitosan oligosaccharide group relative model group also has remarkable reduction (P<0.05) but the too late this product absorption group of degree separately.
3, rosuvastain calcium experimental mice AP Area Ratio is less than above two groups, and difference has conspicuousness (P<0.05); Rosuvastain calcium and this product experimental mice serum TC, LDL-C further reduces and AP Area Ratio (PA/LA) further dwindles, and difference has conspicuousness (P<0.05).
These results suggest that this product is compared takes merely chitosan oligosaccharide and can more effectively reduce serum lipid concentrations in mice serum, slows down the formation of atherosclerotic and tube wall patch, and together with cardiovascular drugs, takes and can play more significant effect.
To sum up; the present invention is according to patient's nutritional need; the special dietary seafood of the composite marine that supplies cardiovascular patient to eat that the chitosan oligosaccharide of take is prepared as primary raw material; not only be conducive to the excretion of cholesterol and reduce blood cholesterol levels; the protection cardiovascular system; thereby improve the symptom of angiocardiopathy and reduce the incidence of Coronary Artery Disease Complicated disease; and multiple natural active matter and multivitamin and the mineral matters such as astaxanthin, beta carotene, allicin, Co-Q10 have been added; can improve the nutrition condition of cardiovascular patient comprehensively, obviously strengthen resistance against diseases.
Above embodiment is only in order to technical scheme of the present invention to be described, but not is limited; Although with reference to previous embodiment, the present invention is had been described in detail, for the person of ordinary skill of the art, still can modify to the technical scheme that previous embodiment is put down in writing, or part technical characterictic wherein is equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution break away from the spirit and scope of the present invention's technical scheme required for protection.
Claims (9)
1. one kind for the special dietary seafood of the edible composite marine of cardiovascular patient, it is characterized in that its material composition content is as follows, in weight portion:
2. according to claim 1 for the special dietary seafood of the edible composite marine of cardiovascular patient, it is characterized in that the special dietary seafood of described composite marine also includes linseed oil 50-200 part.
3. according to claim 1 for the special dietary seafood of the edible composite marine of cardiovascular patient, it is characterized in that the special dietary seafood of described composite marine also includes extractive of flax seed 5-20 part.
4. described for the special dietary seafood of the edible composite marine of cardiovascular patient according to claim 2 or 3, it is characterized in that the special dietary seafood of described composite marine also includes sea cucumber polysaccharide 0.1-5 part, fucoidin sulfuric ester 20-300 part and L-carnitine-L-tartrate 8-30 part.
5. according to claim 1 for the special dietary seafood of the edible composite marine of cardiovascular patient, it is characterized in that: the described chitosan oligosaccharide degree of polymerization is 2-15, and molecular weight is below 5000.
6. according to claim 4 for the special dietary seafood of the edible composite marine of cardiovascular patient, it is characterized in that: the special dietary seafood of described composite marine is capsule, tablet, pulvis, granule, oral liquid or paste.
7. the preparation method for the edible special dietary seafood of composite marine of cardiovascular patient according to claim 1, it is characterized in that it comprises the following steps: choose above-mentioned each material composition, proportioning according to described weight portion adds above-mentioned material, after pulverizing and sieving, mixes; Control temperature at preparation this product content below 60 ℃, under the lucifuge condition, routine operation makes pulvis, granule or capsule, and all operations all carries out in the clean dried environment.
8. the preparation method for the edible special dietary seafood of composite marine of cardiovascular patient according to claim 2, it is characterized in that it comprises the following steps: choose above-mentioned each material composition, proportioning according to described weight portion adds above-mentioned material, material is dropped into to the vacuum emulsification tank, stir, grind to obtain this product content; Gelatin, glycerine, purified water Hybrid Heating are stirred to gelatin and dissolve make softgel shell solution fully, vacuumize degassing, softgel shell solution is incubated to 55 ℃-60 ℃; Get foregoing thing and softgel shell solution, compressing, drying makes soft capsule.
9. the preparation method for the edible special dietary seafood of composite marine of cardiovascular patient according to claim 8, is characterized in that: be under 0.08-0.09MPa, to vacuumize de-bubble to the greatest extent in vacuum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310385262.XA CN103404875B (en) | 2013-08-29 | 2013-08-29 | Complex ocean special-diet food eaten by patients with cardiovascular disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310385262.XA CN103404875B (en) | 2013-08-29 | 2013-08-29 | Complex ocean special-diet food eaten by patients with cardiovascular disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103404875A true CN103404875A (en) | 2013-11-27 |
| CN103404875B CN103404875B (en) | 2014-11-26 |
Family
ID=49597965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310385262.XA Expired - Fee Related CN103404875B (en) | 2013-08-29 | 2013-08-29 | Complex ocean special-diet food eaten by patients with cardiovascular disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103404875B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110393293A (en) * | 2019-07-05 | 2019-11-01 | 上海复旦奥医医学科技有限公司 | A kind of coronary heart disease tailored version clinical nutrition formula and preparation method thereof |
| CN110652513A (en) * | 2018-06-28 | 2020-01-07 | 黑龙江珍宝岛药业股份有限公司 | Pharmaceutical composition containing rosuvastatin calcium and preparation method and application thereof |
| CN115702906A (en) * | 2021-08-09 | 2023-02-17 | 深圳奥萨制药有限公司 | Composition for preventing and improving cardiovascular diseases |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823895A (en) * | 2005-12-29 | 2006-08-30 | 颜怀伟 | Nutritire food for antisenile and anticancer and its manufacturing method |
| CN101474201A (en) * | 2008-12-15 | 2009-07-08 | 北京利千秋科技发展有限公司 | Pharmaceutical composition for reducing blood fat |
| CN103110112A (en) * | 2012-12-03 | 2013-05-22 | 郭威 | Composite anti-oxidation nutritional food and processing method thereof |
-
2013
- 2013-08-29 CN CN201310385262.XA patent/CN103404875B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823895A (en) * | 2005-12-29 | 2006-08-30 | 颜怀伟 | Nutritire food for antisenile and anticancer and its manufacturing method |
| CN101474201A (en) * | 2008-12-15 | 2009-07-08 | 北京利千秋科技发展有限公司 | Pharmaceutical composition for reducing blood fat |
| CN103110112A (en) * | 2012-12-03 | 2013-05-22 | 郭威 | Composite anti-oxidation nutritional food and processing method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 周书凤: "左旋肉碱与心血管疾病", 《国外医学卫生学分册》 * |
| 张文: "《海洋药物导论（第二版）》", 30 September 2012, 上海科学技术出版社 * |
| 张树政等: "《糖生物工程》", 30 June 2012, 化学工业出版社 * |
| 陈华等: "海藻中活性物质的心血管药理作用研究进展", 《中国食物与营养》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110652513A (en) * | 2018-06-28 | 2020-01-07 | 黑龙江珍宝岛药业股份有限公司 | Pharmaceutical composition containing rosuvastatin calcium and preparation method and application thereof |
| CN110393293A (en) * | 2019-07-05 | 2019-11-01 | 上海复旦奥医医学科技有限公司 | A kind of coronary heart disease tailored version clinical nutrition formula and preparation method thereof |
| CN115702906A (en) * | 2021-08-09 | 2023-02-17 | 深圳奥萨制药有限公司 | Composition for preventing and improving cardiovascular diseases |
| CN115702906B (en) * | 2021-08-09 | 2024-09-24 | 深圳奥萨制药有限公司 | Composition for preventing and improving cardiovascular diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103404875B (en) | 2014-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103431392B (en) | Composite marine food for special dietary uses for diabetics | |
| CN106072573A (en) | A kind of it is applicable to the special dietary seafood that old aged muscle decay disease is edible | |
| CN102648752B (en) | Engineering rice suitable for people having unbalanced diet and with function of reducing blood glucose and preparation method of engineering rice | |
| CN103238897A (en) | Composite plant solid drink suitable for diabetic patients | |
| CN103637197A (en) | Propolis soft capsule and preparation method thereof | |
| CN103404765B (en) | Composite marine special dietary food for consumption of tumor patients | |
| CN102726732A (en) | Nutritional supplement of foods for controlling cardiovascular disease, and its application | |
| CN108391811A (en) | A kind of tumour full nutrition formula food and its application | |
| CN106858595A (en) | One kind burn tailored version clinical nutrition formula and preparation method thereof | |
| CN106165905B (en) | A kind of calcium adds vitamine soft capsule and preparation method | |
| CN102048225B (en) | Red-date health protection beverage capable of improving growing development | |
| CN101375727B (en) | Auricularia auricula-ginseng element beverage | |
| CN105124347A (en) | Moringa oleifera blood-glucose-reducing composition and preparation method thereof | |
| CN105533688A (en) | Healthcare soft capsule with assistant blood-sugar reducing effect and preparation method thereof | |
| CN103404875B (en) | Complex ocean special-diet food eaten by patients with cardiovascular disease | |
| CN105878397A (en) | Composition capable of regulating transportation stress of cattle and sheep | |
| CN103125808A (en) | Antioxidant composite tablet for beauty and preparation method thereof | |
| CN108541912A (en) | A kind of anti-oxidant blood-fat reducing composition and its preparation method and application | |
| CN103005251A (en) | Dilapidated wall three-in-one type royal jelly product | |
| CN110393293A (en) | A kind of coronary heart disease tailored version clinical nutrition formula and preparation method thereof | |
| CN105166620A (en) | Horseradish tree composition capable of reducing blood lipid and preparation method of horseradish tree composition | |
| CN105831730A (en) | Krill oil composite special dietary food for reducing hypertension, hyperglycemia and hyperlipidemia | |
| CN104770658A (en) | Selenium-enriched wheat flour and flour for non-fried ripple noodle and ripple noodle | |
| CN109090319A (en) | Newborn mineral salt pressed candy | |
| CN101224005B (en) | Nutrient tablet possessing whole nutrient supplementing efficacy and producing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141126 Termination date: 20210829 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |