CN104224890B - A kind of xanthophyll soft capsule and preparation method thereof - Google Patents
A kind of xanthophyll soft capsule and preparation method thereof Download PDFInfo
- Publication number
- CN104224890B CN104224890B CN201410367651.4A CN201410367651A CN104224890B CN 104224890 B CN104224890 B CN 104224890B CN 201410367651 A CN201410367651 A CN 201410367651A CN 104224890 B CN104224890 B CN 104224890B
- Authority
- CN
- China
- Prior art keywords
- capsule
- content
- soft capsule
- weight
- glue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 32
- 229960005375 lutein Drugs 0.000 title claims abstract description 31
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 title claims abstract description 31
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 title claims abstract description 31
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 title claims abstract description 31
- 235000008210 xanthophylls Nutrition 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000002775 capsule Substances 0.000 claims abstract description 55
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 26
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 108010010803 Gelatin Proteins 0.000 claims abstract description 13
- 235000013871 bee wax Nutrition 0.000 claims abstract description 13
- 239000012166 beeswax Substances 0.000 claims abstract description 13
- 229920000159 gelatin Polymers 0.000 claims abstract description 13
- 239000008273 gelatin Substances 0.000 claims abstract description 13
- 235000019322 gelatine Nutrition 0.000 claims abstract description 13
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 13
- 235000011187 glycerol Nutrition 0.000 claims abstract description 13
- 235000021388 linseed oil Nutrition 0.000 claims abstract description 13
- 239000000944 linseed oil Substances 0.000 claims abstract description 13
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 13
- 238000004040 coloring Methods 0.000 claims abstract description 10
- 239000001656 lutein Substances 0.000 claims abstract description 10
- 235000012680 lutein Nutrition 0.000 claims abstract description 10
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims abstract description 10
- 239000008213 purified water Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims abstract description 9
- 244000078534 Vaccinium myrtillus Species 0.000 claims abstract description 9
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 9
- 229960003080 taurine Drugs 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 10
- 239000003292 glue Substances 0.000 claims description 9
- 239000000084 colloidal system Substances 0.000 claims description 6
- 239000001993 wax Substances 0.000 claims description 6
- 239000000049 pigment Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 206010030113 Oedema Diseases 0.000 claims description 3
- 230000036760 body temperature Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000004513 sizing Methods 0.000 claims description 3
- 210000000952 spleen Anatomy 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 abstract description 19
- 208000003464 asthenopia Diseases 0.000 abstract description 10
- 206010034960 Photophobia Diseases 0.000 abstract description 3
- 206010047513 Vision blurred Diseases 0.000 abstract description 3
- 239000004173 sunset yellow FCF Substances 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000004310 photopic vision Effects 0.000 description 12
- 230000006872 improvement Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000004438 eyesight Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 208000022873 Ocular disease Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000000528 statistical test Methods 0.000 description 2
- 206010015958 Eye pain Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 239000004233 Indanthrene blue RS Substances 0.000 description 1
- 235000016357 Mirtillo rosso Nutrition 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 description 1
- 244000077923 Vaccinium vitis idaea Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000004106 carminic acid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000007887 hard shell capsule Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 238000002577 ophthalmoscopy Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Abstract
The present invention relates to a kind of xanthophyll soft capsule and preparation method thereof, xanthophyll soft capsule is made up of capsule skin and capsule 's content, wherein, the capsule 's content is made up of the raw material of following parts by weight：Bilberry fruit P.E 110 ~ 130, lutein 12 ~ 20, taurine 45 ~ 60, natural β ~ carrotene 7 ~ 11, phosphatidase 2 ~ 2.4, beeswax 24 ~ 29 and linseed oil 200 ~ 250；The capsule skin is made up of the raw material of following parts by weight：Gelatin 130 ~ 170, glycerine 62 ~ 72, purified water 110 ~ 130, light blue 0.029 ~ 0.032, temptation red 0.0275 ~ 0.0295, burnt sugar coloring 0.1428 ~ 0.1628 and titanium dioxide 0.2192 ~ 0.2392.Beneficial effect of the present invention：Compatibility rationally, with effective alleviates the symptoms such as visual fatigue, blurred vision, the eye dry and astringent, eye is swollen, ophthalmodynia, the photophobia that improve patient.
Description
Technical field
The present invention relates to field of health care products, more particularly to a kind of xanthophyll soft capsule and preparation method thereof.
Background technology
With the popularization of the electronic product such as Chinese society expanding economy and computer, TV and smart mobile phone, liquid crystal display
Screen has been deep into daily life, and eyes cause heavy bear before the fluorescent screen of flicker to eyes for a long time
Load, causes visual fatigue, promotes retinal ocular disease to be fallen ill with some chronic ocular diseases and is raised in advance with illness rate.Visual fatigue be it is a kind of with
Subjective symptoms is the eye syndrome of main clinical manifestation, and the generation of visual fatigue is eye or whole body apparatus factors and psychiatric
The result that factor is intertwined to form.Headache, dizziness, spasm of ocular muscles, induction stomach function barrier can be produced under visual fatigue serious conditions
Hinder, the symptom such as whole body is uncomfortable.
Many alleviates the products such as tablet, hard shell capsules of visual fatigues by main component of lutein currently on the market, due to it
Component compatibility is unreasonable, function approach is single can not meet people's alleviation visual fatigue, prevention macular degeneration and protect eyes
The need for.
The content of the invention
It is an object of the invention to provide a kind of xanthophyll soft capsule and preparation method thereof, to overcome the upper of prior art presence
State deficiency.
The purpose of the present invention is to be achieved through the following technical solutions：
A kind of xanthophyll soft capsule, is made up of capsule skin and capsule 's content, wherein, the capsule 's content is by following heavy
The raw material of amount part is made：Bilberry fruit P.E 110 ~ 130, lutein 12 ~ 20, taurine 45 ~ 60, natural β ~ carrotene 7 ~ 11, phosphorus
Fat 2 ~ 2.4, beeswax 24 ~ 29 and linseed oil 200 ~ 250；The capsule skin is made up of the raw material of following parts by weight：Gelatin 130 ~
170th, glycerine 62 ~ 72, purified water 110 ~ 130, light blue 0.029 ~ 0.032, lure red 0.0275 ~ 0.0295, burnt sugar coloring 0.1428 ~
0.1628 and titanium dioxide 0.2192 ~ 0.2392.
The preparation method of above-mentioned xanthophyll soft capsule, comprises the following steps：
1）The preparation of capsule skin is prepared, is comprised the following steps：The titanium dioxide and glycerine of equivalent is taken to be sufficiently mixed, grind
The titanium dioxide suspension crossed afterwards after 300 mesh sieves, and mixed with burnt sugar coloring, the red, light blue of temptation, obtain pigment solution；By above-mentioned steps
In the purified water of remaining glycerine and formula ratio be heated to 70 ~ 80 degree, put into gelatin and stir to gelatin and be completely dissolved；By container
Interior air is evacuated to ~ 0.07 ~ 0.10Mpa, and is kept for 10 ~ 20 minutes to capsule bubble-free, and capsule liquid then is crossed into 150 mesh sieves and put
Go out glue, be placed in glue-storing barrel, add pigment solution and stir, stand more than 3 hours, but cannot be greater than or be equal to
24 hours, and 60 degree or so of glue is kept, it is standby；
2）Capsule 's content is prepared, is comprised the following steps：The linseed oil and beeswax of half parts by weight in formula are added
Heat is to 65 ~ 75 DEG C, and stirring is completely dissolved to beeswax and by 300 mesh screens, adds the parts by weight of remaining half in formula
Linseed oil in stir, cross colloid mill obtain oily wax liquor, it is stand-by；Again by natural β ~ carrotene, lutein, phosphatide, cowberry
Extract and taurine are added in oily wax liquor and stirred, and obtain mixed material；Mixed material is crossed into colloid mill grinding, then put
Stirred 20 minutes in vacuum emulsifying machine, cross 100 mesh sieves after observation bubble-free and release, obtain capsule 's content in capsule；
3）Pelleting, sizing
Capsule 's content, glue in capsule are pressed into soft capsule in encapsulating machine, it is 1.5 ~ 3.0 revs/min to keep rotating speed
Clock, sprinkler body temperature is kept for 35 ~ 50 DEG C, and rubber thickness is 0.78 ~ 0.85mm, and loading amount is 0.45g/；The soft capsule pressed is put
In rotating cage, shaped 1.0 ~ 2.5 hours under conditions of 18 ~ 26 DEG C of temperature, relative humidity 20 ~ 40%；
4）Dry
Obtained soft capsule is put in dry pallet, under conditions of 15 ~ 30 DEG C of temperature, relative humidity 15 ~ 30%, dried
Soft capsule can be obtained by being less than 11% with the up to capsule severe edema due to hypofunction of the spleen point within 24 hours.
Beneficial effects of the present invention are：Present invention aims at existing for prior art, component compatibility is unreasonable, function
Action pathway is single, bioavailability is low, effect is poor etc. it is not enough there is provided it is a kind of safely and effectively, compatibility rationally, with effective alleviation
Symptom, prevention macular degeneration and the protect eyes such as visual fatigue, blurred vision, eye dry and astringent, eye is swollen, ophthalmodynia, the photophobia for improving patient
Xanthophyll soft capsule and preparation method thereof.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to institute in embodiment
The accompanying drawing needed to use is briefly described, it should be apparent that, drawings in the following description are only some implementations of the present invention
Example, for those of ordinary skill in the art, on the premise of not paying creative work, can also be obtained according to these accompanying drawings
Obtain other accompanying drawings.
Fig. 1 is the three-dimensional block diagram of triangle disposition on inspection table described according to embodiments of the present invention.
Embodiment
Embodiment 1
A kind of xanthophyll soft capsule described in the embodiment of the present invention 1, is made up of capsule skin and capsule 's content, in the capsule
It is tolerant by following weight（kg）Raw material be made：Bilberry fruit P.E 115, lutein 15.2, taurine 56, natural β ~ carrotene
10th, phosphatidase 2 .2, beeswax 29 and linseed oil 223；The capsule skin is by following weight（kg）Raw material be made：Gelatin 153.2,
Glycerine 67.86, purified water 122.56, light blue 0.0308, temptation red 0.0287, burnt sugar coloring 0.1528 and titanium dioxide 0.2292.
A kind of preparation method of xanthophyll soft capsule described in embodiment 1 comprises the following steps：
1）Prepare capsule skin
Take the titanium dioxide and glycerine of equivalent 0.2292 to be sufficiently mixed, grind after cross 300 mesh sieves after titanium dioxide be suspended
Liquid, and mixed with burnt sugar coloring, the red, light blue of temptation, obtain pigment solution；By the purified water of remaining glycerine and formula ratio in above-mentioned steps
70 ~ 80 degree are heated to, gelatin is put into and stirring to gelatin is completely dissolved；Air in container is evacuated to ~ 0.07 ~ 0.10Mpa, and
Kept for 10 ~ 20 minutes to capsule bubble-free, capsule liquid is then crossed into 150 mesh sieves and releases glue, is placed in glue-storing barrel, adds color
Plain solution ＆ stir is uniform, stands more than 3 hours, but cannot be greater than or equal to 24 hours, and keeps 60 degree or so of glue, standby
With；
2）Prepare capsule 's content
Linseed oil and beeswax are heated to 65 ~ 75 DEG C, stirring is completely dissolved to beeswax and by 300 mesh screens, plus
Enter in formula and stirred in remaining linseed oil, cross colloid mill and obtain oily wax liquor, it is stand-by；It is again that natural β ~ carrotene, leaf is yellow
Element, phosphatide, Bilberry fruit P.E and taurine are added in oily wax liquor and stirred, and obtain mixed material；Mixed material is crossed into colloid
Mill grinding, is subsequently placed in vacuum emulsifying machine and stirs 20 minutes, crosses 100 mesh sieves after observation bubble-free and releases, obtains capsule in capsule
Content；
3）Pelleting, sizing
Capsule 's content, glue in capsule are pressed into soft capsule in encapsulating machine, it is 1.5 ~ 3.0 revs/min to keep rotating speed
Clock, sprinkler body temperature is kept for 35 ~ 50 DEG C, and rubber thickness is 0.78 ~ 0.85mm, and loading amount is 0.45g/；The soft capsule pressed is put
In rotating cage, shaped 1.0 ~ 2.5 hours under conditions of 18 ~ 26 DEG C of temperature, relative humidity 20 ~ 40%；
4）Dry
Obtained soft capsule is put in dry pallet, under conditions of 15 ~ 30 DEG C of temperature, relative humidity 15 ~ 30%, dried
Soft capsule can be obtained by being less than 11% with the up to capsule severe edema due to hypofunction of the spleen point within 24 hours.
Embodiment 2
A kind of xanthophyll soft capsule described in the embodiment of the present invention 2, including capsule skin and capsule 's content, the capsule contents
Thing is by following weight（kg）Raw material be made：Bilberry fruit P.E 110, lutein 15.6, taurine 60, natural β ~ carrotene 9,
Phosphatidase 2, beeswax 29 and linseed oil 220；The capsule skin is by following weight（kg）Raw material be made：Gelatin 130, glycerine 72,
Purified water 120, light blue 0.029, temptation red 0.0295, burnt sugar coloring 0.01428 and titanium dioxide 0.2392.
A kind of preparation method of xanthophyll soft capsule is consistent with the preparation method in embodiment 1 described in embodiment 2.
Embodiment 3
A kind of xanthophyll soft capsule described in the embodiment of the present invention 3, including capsule skin and capsule 's content, the capsule contents
Thing is by following weight（kg）Raw material be made：Bilberry fruit P.E 130, lutein 20, taurine 45, natural β ~ carrotene 11, phosphorus
Fat 2.4, beeswax 24 and linseed oil 200；The capsule skin is by following weight（kg）Raw material be made：Gelatin 170, glycerine 62,
Purified water 130, light blue 0.032, temptation red 0.0275, burnt sugar coloring 0.1628 and titanium dioxide 0.2192.
A kind of preparation method of xanthophyll soft capsule is consistent with the preparation method in embodiment 1 described in embodiment 3.
Embodiment 4
A kind of xanthophyll soft capsule described in the embodiment of the present invention 4, including capsule skin and capsule 's content, the capsule contents
Thing is by following weight（kg）Raw material be made：Bilberry fruit P.E 120, lutein 12, taurine 50, natural β ~ carrotene 7, phosphorus
Fat 2.1, beeswax 26 and linseed oil 250；The capsule skin is by following weight（kg）Raw material be made：Gelatin 149, glycerine
69.8th, purified water 110, light blue 0.031, temptation red 0.0281, burnt sugar coloring 0.1518 and titanium dioxide 0.2392.
A kind of preparation method of xanthophyll soft capsule is consistent with the preparation method in embodiment 1 described in embodiment 4.
The test-meal response situation of the xanthophyll soft capsule：
1st, subject chooses the adult of 18 ~ 65 one full year of life and uses eye vision fatigue person for a long time.
2nd, the exclusion standard of subject：
（1）With infectious, traumatic eye part disease person.Carry out less than 3 months persons of operated eye.
（2）With eye disease patient inside and outside cornea, crystal, vitreum, eyeground pathological changes etc..
（3）With the disease patient such as angiocarpy, the cerebrovascular, liver, kidney, hemopoietic system.
（4）Gestation or women breast-feeding their children, allergic constitution patient.
（5）The article relevant with tested function is taken in a short time, has influence on the judgement person to result.
（6）Long-term taking health products or fails terminator about treating the medicine of eyesight using other treatment method.
3rd, experimental design and packet are required：Using itself between group two kinds of control designs.Entered according to random, double blinding requirement
Row packet, according to symptom and eye test situation during packet, makes test-meal group and the symptom and eyesight horizontal equalization of control group.Simultaneously
Consider the factors such as age, sex, make two groups there is comparativity.Every group of number of subjects is no less than 50 during test-meal off-test
Example.
4th, the dosage and application method of tested material：Test-meal group takes tested material, control group clothes by recommendation method and recommended amounts
With placebo, subject's Time of Administration is continuous 60 days.
5th, observation index：
（1）Safety indexes before and after test-meal：Blood, routine urianlysis, physical examination；Liver and kidney function is checked；Chest X-rays or X
Mating plate, electrocardiogram, abdominal B-scan ultrasonography inspection.
（2）Efficiency index：In test-meal start and at the end of check, survey：Symptom inquires, uses eye situation；Ophthalmology
Check：Including funduscopy, eye test（Myopia, long sight, astigmatism etc.）；The assay method of duration of photopic vision sees below described.
6th, effect criterion
（1）Symptom improves efficient：Eye ache, eye is swollen, photophobia, blurred vision, dry and astringent eye, foreign body sensation, shed tears, whole body not
Fitting has 3 kinds of improvement in 8 kinds of symptoms, and other symptoms improve without i.e. judgement symptom is deteriorated.Calculating two groups of symptoms improves number of cases and two
Group symptom improves efficient.Symptom improves efficient（%）Computational methods are that symptom improves number of cases/test-meal number of cases × 100.By two groups
Symptom improves efficient progress statistical test.
（2）Symptom average integral：The symptom integral before and after every examination trencherman's test-meal is calculated, two groups of average product is calculated respectively
Score value, and statistical test is carried out, following chart 1 show visual fatigue symptom decision method（Sxemiquantitative integration method）.
Table 1
Note：" random thoughts " refer to 1-2 times/2 days in table；" when have " refers to 1-3 times/day；" frequent " refers to>3 times/day
7th, vision improvement rate：So that, compared with two behaviors improvement is improved before test-meal, what two groups of statistics was taken after tested material regards after test-meal
Power improvement rate is used as reference index.
8th, duration of photopic vision：Test-meal group itself compare or test-meal group and control group group between compared, duration of photopic vision difference has
Conspicuousness（p<0.05）, and it is effective that average duration of photopic vision, which is improved more than or equal to 10%,.
9th, result of the test:Subject in the safe performance indexes before and after experiment in normal range (NR), 8 kinds of diseases after experiment
Shape has more than 3 kinds of improvement rate more than 98%；According to the reference standard in table 1, compared with the probability that two rows are improved before test-meal after test-meal
For 99.7%；Test-meal group itself compare or test-meal group and control group group between compared, duration of photopic vision difference has conspicuousness（p<
0.05）, and average duration of photopic vision raising is more than or equal to 10%.
Show that the xanthophyll soft capsule tested material helps to alleviate the effect of visual fatigue function according to above-mentioned experiment,
And effect is obvious.
The assay method of duration of photopic vision：
As shown in Figure 1：The three-dimensional block diagram of triangle disposition is drawn on table is checked, square is per length of side 1cm, local lighting 100
LX-150 LX（The lamp box specially made can be used）.During measure, checking the distance of table and eyes should practise according to subject regarding thing
Used to be maintained at that suitable distance is motionless, regulation subject sees that " product " word image is considered as photopic vision, fall " product " word when be not photopic vision.Determine
Time is 3min.
Allowed during inspection subject it is hand-held can interrupted timing stopwatch, examiner sent after the password of beginning, and subject is immediately
The pattern watched attentively in square（Or open lamp box switch）, while starting the manual time-keeping in hand.See down during being look at
The pause switch of stopwatch is pressed during " product " word immediately；See and start stopwatch again when being in " product " word image, be so repeated.Survey
Subject hears that the password of examiner stops stopwatch immediately at the end of determining to stipulated time 3min, and stopwatch is passed by this period
Reading is exactly the total time that subject regards " product " word image as, i.e. the photopic vision time.
Duration of photopic vision=（The photopic vision time/watch total time attentively）×100%
Place and illumination are should be noted that during measure, the also use eye degree with subject before tested is relevant, should be noted that before experiment.
The present invention is not limited to above-mentioned preferred forms, and anyone can show that other are various under the enlightenment of the present invention
The product of form, however, make any change in its shape or structure, it is every that there is skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (2)
1. a kind of xanthophyll soft capsule, it is made up of capsule skin and capsule 's content, it is characterised in that
The capsule skin is made up of the raw material of following parts by weight：Gelatin 153.2, glycerine 67.86, purified water 122.56, light blue
0.0308th, red 0.0287, burnt sugar coloring 0.1528 and titanium dioxide 0.2292 are lured；And
The capsule 's content is made up of the raw material of following parts by weight：Bilberry fruit P.E 115, lutein 15.2, taurine 56, day
So ~ bata-carotene 10, phosphatidase 2 .2, beeswax 29 and linseed oil 223.
2. the preparation method of the xanthophyll soft capsule described in claim 1, it is characterised in that comprise the following steps：
1）Capsule skin is prepared, is comprised the following steps：Take the titanium dioxide and glycerine of equivalent to be sufficiently mixed, grind after cross 300 mesh sieves
Titanium dioxide suspension afterwards, and mixed with burnt sugar coloring, the red, light blue of temptation, obtain pigment solution；By remaining glycerine in above-mentioned steps
70 ~ 80 degree are heated to the purified water of formula ratio, gelatin is put into and stirring to gelatin is completely dissolved；Air in container is taken out
To -0.07 ~ 0.1Mpa, and kept for 10-20 minutes to capsule bubble-free, capsule liquid is then crossed into 150 mesh sieves and releases glue, is placed in
In glue-storing barrel, add pigment solution and stir, stand more than 3 hours, but cannot be greater than or equal to 24 hours, and protect
60 degree or so of glue is held, it is standby；
2）Capsule 's content is prepared, is comprised the following steps：The linseed oil and beeswax of half parts by weight are heated to 65 ~ 75
DEG C, stirring is completely dissolved to beeswax and by 300 mesh screens, adds the linseed oil of second half remaining parts by weight in formula
In stir, cross colloid mill obtain oily wax liquor, it is stand-by；Again by natural β ~ carrotene, lutein, phosphatide, Bilberry fruit P.E and ox
Sulfonic acid is added in oily wax liquor and stirred, and obtains mixed material；Mixed material is crossed into colloid mill grinding, vacuum emulsification is subsequently placed in
Stirred 20 minutes in machine, cross 100 mesh sieves after observation bubble-free and release, obtain capsule 's content in capsule；
3）Pelleting, sizing：Capsule 's content, glue in capsule are pressed into soft capsule in encapsulating machine, keep rotating speed be 1.5 ~
3.0 revs/min, sprinkler body temperature is kept for 35 ~ 50 DEG C, and rubber thickness is 0.78 ~ 0.85mm, and loading amount is 0.45g/；By what is pressed
Soft capsule is placed in rotating cage, is shaped 1.0 ~ 2.5 hours under conditions of 18 ~ 26 DEG C of temperature, relative humidity 20 ~ 40%；And
4）Dry：Obtained soft capsule is put in dry pallet, under conditions of 15 ~ 30 DEG C of temperature, relative humidity 15 ~ 30%, done
It is less than 11% with the up to capsule severe edema due to hypofunction of the spleen point within dry 24 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410367651.4A CN104224890B (en) | 2014-07-29 | 2014-07-29 | A kind of xanthophyll soft capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410367651.4A CN104224890B (en) | 2014-07-29 | 2014-07-29 | A kind of xanthophyll soft capsule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104224890A CN104224890A (en) | 2014-12-24 |
| CN104224890B true CN104224890B (en) | 2017-09-19 |
Family
ID=52214369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410367651.4A Active CN104224890B (en) | 2014-07-29 | 2014-07-29 | A kind of xanthophyll soft capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104224890B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030877A (en) * | 2015-07-13 | 2015-11-11 | 北京世纪合辉医药科技股份有限公司 | Healthcare food for relieving asthenopia and preparation method thereof |
| CN106236739B (en) | 2016-07-27 | 2019-06-07 | 上海宣泰生物科技有限公司 | Contain lutein/lutein ester composition and its application |
| CN106880046A (en) * | 2017-02-10 | 2017-06-23 | 合肥师范学院 | A kind of Blueberry pigment soft capsule and preparation method thereof |
| CN107307418B (en) * | 2017-07-01 | 2020-11-20 | 山东健康源生物工程有限公司 | Blueberry vitamin A soft capsule for relieving visual fatigue and preparation method thereof |
| CN107279976A (en) * | 2017-07-01 | 2017-10-24 | 山东健康源生物工程有限公司 | A kind of natural VE adds bata-carotene soft capsule and preparation method thereof |
| CN107375504A (en) * | 2017-08-15 | 2017-11-24 | 庞会心 | A kind of composition for preventing and treating visual fatigue and preparation method and application |
| CN107440036A (en) * | 2017-08-25 | 2017-12-08 | 山东禹王制药有限公司 | A kind of Halth-care composition, its preparation and preparation method for improving memory, improving eyesight |
| CN110115382A (en) * | 2018-02-05 | 2019-08-13 | 常州英莱克斯生物工程有限公司 | A kind of bright soft capsule of benefit that can alleviate visual fatigue and its production method |
| CN108392549A (en) * | 2018-03-29 | 2018-08-14 | 开封红枫叶生物科技有限公司 | A kind of resveratrol soft capsules and preparation method thereof with auxiliary lipid-lowering function |
| CN109463521A (en) * | 2018-12-29 | 2019-03-15 | 浙江艾兰得生物科技有限公司 | A kind of manufacture craft of blueberry lutein ester gel candy |
| CN109645202A (en) * | 2018-12-29 | 2019-04-19 | 浙江艾兰得生物科技有限公司 | A kind of formula that blueberry lutein ester gel candy is sandwich |
| CN114468294B (en) * | 2022-01-24 | 2024-04-02 | 河南农业大学 | Nanoemulsion simultaneously loaded with linseed oil and lutein and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102144780A (en) * | 2010-12-28 | 2011-08-10 | 崔晓廷 | Lutein ester health care product for protecting eyesight and preparation method thereof |
| CN102960738A (en) * | 2012-12-20 | 2013-03-13 | 汤臣倍健股份有限公司 | Bilberry and lutein soft capsule and preparation method thereof |
-
2014
- 2014-07-29 CN CN201410367651.4A patent/CN104224890B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102144780A (en) * | 2010-12-28 | 2011-08-10 | 崔晓廷 | Lutein ester health care product for protecting eyesight and preparation method thereof |
| CN102960738A (en) * | 2012-12-20 | 2013-03-13 | 汤臣倍健股份有限公司 | Bilberry and lutein soft capsule and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104224890A (en) | 2014-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104224890B (en) | A kind of xanthophyll soft capsule and preparation method thereof | |
| CN101766307B (en) | Health food with function of relieving visual fatigue and preparation method thereof | |
| CN101856118A (en) | Health-care food for relieving asthenopia and preparation method thereof | |
| CN102763847B (en) | Health-care food with function of relieving visual fatigue and preparation method thereof | |
| CN102225087A (en) | Xanthophyll compound preparation with powerful eye-protecting effect | |
| CN103300373A (en) | Lutein and procyanidine composite soft capsule and preparation method thereof | |
| CN101505773A (en) | Agent for treating eye diseases | |
| CN104147081A (en) | Blueberry lutein soft capsule for improving eyesight and manufacturing method thereof | |
| CN103566049A (en) | Composition for improving density of macular pigment in eyes and preventing or treating age-related macular degeneration | |
| CN103735733A (en) | Compound preparation containing lutein ester and preparation method thereof | |
| CN101595977A (en) | Be of value to the formula food and the application thereof of eyes duration of photopic vision | |
| CN105341946A (en) | Dunaliella salina, lutein and huckleberry composition, soft capsule containing composition and preparation method of soft capsule | |
| CN107397029A (en) | A kind of blueberry lutein ester pressed candy | |
| CN102362924B (en) | Medicinal composition for treating ophthalmic diseases and preparation method thereof | |
| CN107410643A (en) | With haematococcus pluvialis pressed candy for alleviating visual fatigue and preparation method thereof | |
| CN105520137B (en) | It is a kind of that there is the health food alleviated visual fatigue and protect visual function | |
| CN106692187A (en) | Composition for improving visuognosis persistence and protecting eye health | |
| CN101999477A (en) | Eyesight-protecting edible oil | |
| CN105054004A (en) | Composite soft dendrobium huoshanense capsule and preparation method thereof | |
| CN102370658B (en) | Eyedrops for treating presbyopia and preparation method thereof | |
| CN102150860B (en) | Composition for easing visual fatigue and assisting in improving memory | |
| CN104147380B (en) | It is a kind of that there is the pharmaceutical composition for alleviating visual fatigue effect, preparation method and application | |
| CN107308316A (en) | A kind of medicine for treating myopia | |
| CN107029037A (en) | It is a kind of to improve the eyesight-improving health care function patch of eyes based on nitric oxide principle | |
| CN106420816A (en) | Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: Room 1403, Room 1401, 14th Floor, No. 8 Chaoyangmen South Street, Chaoyang District, Beijing, 100000 Patentee after: Zhonghong Biotechnology (Beijing) Co.,Ltd. Address before: Room 503-Z, A18 Xinjiekou Outer Street, Xicheng District, Beijing, 100000 Patentee before: ZHONGHONG BIOLOGICAL ENGINEERING Co.,Ltd. |
|
| CP03 | Change of name, title or address |