CN106880046A - A kind of Blueberry pigment soft capsule and preparation method thereof - Google Patents
A kind of Blueberry pigment soft capsule and preparation method thereof Download PDFInfo
- Publication number
- CN106880046A CN106880046A CN201710072468.5A CN201710072468A CN106880046A CN 106880046 A CN106880046 A CN 106880046A CN 201710072468 A CN201710072468 A CN 201710072468A CN 106880046 A CN106880046 A CN 106880046A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- blueberry pigment
- glue
- blueberry
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 85
- 235000003095 Vaccinium corymbosum Nutrition 0.000 title claims abstract description 67
- 235000017537 Vaccinium myrtillus Nutrition 0.000 title claims abstract description 67
- 235000021014 blueberries Nutrition 0.000 title claims abstract description 67
- 239000000049 pigment Substances 0.000 title claims abstract description 59
- 244000077233 Vaccinium uliginosum Species 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 19
- 108010010803 Gelatin Proteins 0.000 claims abstract description 14
- 229920000159 gelatin Polymers 0.000 claims abstract description 14
- 239000008273 gelatin Substances 0.000 claims abstract description 14
- 235000019322 gelatine Nutrition 0.000 claims abstract description 14
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 14
- 239000002775 capsule Substances 0.000 claims abstract description 13
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims abstract description 12
- 229940083466 soybean lecithin Drugs 0.000 claims abstract description 12
- 239000000084 colloidal system Substances 0.000 claims abstract description 10
- 239000003549 soybean oil Substances 0.000 claims abstract description 10
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 10
- 239000003292 glue Substances 0.000 claims description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 12
- 240000000851 Vaccinium corymbosum Species 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 238000009413 insulation Methods 0.000 claims description 10
- 238000004513 sizing Methods 0.000 claims description 10
- 238000010792 warming Methods 0.000 claims description 10
- 238000003801 milling Methods 0.000 claims description 8
- 230000036760 body temperature Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000011068 loading method Methods 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000004945 emulsification Methods 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000002390 rotary evaporation Methods 0.000 claims description 4
- 241000256844 Apis mellifera Species 0.000 claims 1
- 235000013871 bee wax Nutrition 0.000 abstract description 17
- 239000012166 beeswax Substances 0.000 abstract description 15
- 239000003921 oil Substances 0.000 abstract description 10
- 235000019198 oils Nutrition 0.000 abstract description 10
- 239000003381 stabilizer Substances 0.000 abstract description 6
- 244000170916 Paeonia officinalis Species 0.000 abstract description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 206010047571 Visual impairment Diseases 0.000 abstract 1
- 229940055416 blueberry extract Drugs 0.000 abstract 1
- 235000019216 blueberry extract Nutrition 0.000 abstract 1
- 238000003475 lamination Methods 0.000 abstract 1
- 239000002932 luster Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000003860 storage Methods 0.000 abstract 1
- 208000029257 vision disease Diseases 0.000 abstract 1
- 230000004393 visual impairment Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000000375 suspending agent Substances 0.000 description 7
- 244000068988 Glycine max Species 0.000 description 5
- 235000010469 Glycine max Nutrition 0.000 description 5
- 235000010445 lecithin Nutrition 0.000 description 5
- 239000000787 lecithin Substances 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 4
- -1 flavone compound Chemical class 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 239000006187 pill Substances 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- VEVZSMAEJFVWIL-UHFFFAOYSA-O cyanidin cation Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 VEVZSMAEJFVWIL-UHFFFAOYSA-O 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- KZMACGJDUUWFCH-UHFFFAOYSA-O malvidin Chemical compound COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O)=C1 KZMACGJDUUWFCH-UHFFFAOYSA-O 0.000 description 2
- VYIRVAXUEZSDNC-TXDLOWMYSA-N (3R,3'S,5'R)-3,3'-dihydroxy-beta-kappa-caroten-6'-one Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC(=O)[C@]1(C)C[C@@H](O)CC1(C)C VYIRVAXUEZSDNC-TXDLOWMYSA-N 0.000 description 1
- HXBYBCASAVUYKF-YTQLPXDHSA-N (4r,5s,6s,7r)-4,5,6,7,8-pentahydroxyoctane-2,3-dione Chemical compound CC(=O)C(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO HXBYBCASAVUYKF-YTQLPXDHSA-N 0.000 description 1
- VYIRVAXUEZSDNC-LOFNIBRQSA-N Capsanthyn Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CC(O)CC2(C)C VYIRVAXUEZSDNC-LOFNIBRQSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- GCPYCNBGGPHOBD-UHFFFAOYSA-N Delphinidin Natural products OC1=Cc2c(O)cc(O)cc2OC1=C3C=C(O)C(=O)C(=C3)O GCPYCNBGGPHOBD-UHFFFAOYSA-N 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000165940 Houjia Species 0.000 description 1
- 240000001549 Ipomoea eriocarpa Species 0.000 description 1
- 235000005146 Ipomoea eriocarpa Nutrition 0.000 description 1
- DUKURNFHYQXCJG-UHFFFAOYSA-N Lewis A pentasaccharide Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(C)=O)C(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)OC1CO DUKURNFHYQXCJG-UHFFFAOYSA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229930014669 anthocyanidin Natural products 0.000 description 1
- 150000001453 anthocyanidins Chemical class 0.000 description 1
- 235000008758 anthocyanidins Nutrition 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- WRANYHFEXGNSND-LOFNIBRQSA-N capsanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CCC(O)C2(C)C WRANYHFEXGNSND-LOFNIBRQSA-N 0.000 description 1
- 235000018889 capsanthin Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000007336 cyanidin Nutrition 0.000 description 1
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 description 1
- JKHRCGUTYDNCLE-UHFFFAOYSA-O delphinidin Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 JKHRCGUTYDNCLE-UHFFFAOYSA-O 0.000 description 1
- 235000007242 delphinidin Nutrition 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000021022 fresh fruits Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 235000009584 malvidin Nutrition 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000008239 natural water Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 150000004880 oxines Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000001688 paprika extract Substances 0.000 description 1
- 235000012658 paprika extract Nutrition 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of Blueberry pigment soft capsule and preparation method thereof.The content of the Blueberry pigment soft capsule is made up of Blueberry pigment medicinal extract, soybean oil, soybean lecithin and beeswax, and soft capsule shell is made up of gelatin, G ＆ W.Beeswax and soybean lecithin can be such that Blueberry pigment is uniformly suspended in soybean oil as suspending stabilizer, then by colloid mill milled processed, can improve the stability of content, prevent the appearance of lamination.The softgel shell of the soft capsule is soft or hard suitable, in good taste, and causes that soft capsule is bonded in storage with capsule is not susceptible in transit, is not susceptible to oil leak, is adapted to pelleting, and production efficiency is high.It is natural blueberry extract that the present invention is raw materials used, can prevent teenager's visual impairment, alleviation kopiopia, and its particle neat appearance, and color and luster is sparkling and crystal-clear, peony, meets the consumer psychology of masses.
Description
Technical field
The invention belongs to blueberry mixed health food processing field, and in particular to a kind of preparation method of Blueberry pigment soft capsule.
Background technology
Contain substantial amounts of pigment (accounting for the 0.07~3.38% of fresh fruit) in Blueberry, regard red with anti-oxidant, promotion
Element synthesize again, enhance immunity, anti-cardiovascular disease, anti-ageing various physiological active functionses of waiting for a long time, in food, cosmetics, medicine
Had broad application prospects Deng field.Blueberry pigment is the natural water colo(u)r of the class of nature one, is belonged to 2- phenyl benzene
And pyrans (C6-C3-C6) it is the flavone compound of parent nucleus, by cyanidin, delphinidin, malvidin, Chinese herbaceous peony color
5 kinds of anthocyanidin such as element, morning glory pigment, and each of which and glucose, acetyl glucosamine, galactolipin, acetyl galactose, Ah
Uncle's sugar, acetyl arabinose is drawn to connect the anthocyanin to be formed and constituted.With the improvement of people ' s living standards with health perception
Enhancing, increasingly increases the food demand rich in nutrient and with healthcare function composition.Although Blueberry pigment has various rush
Enter health and disease preventing and treating effect, but if the protection without other media, in the presence of illumination, high temperature and oxygen very
It is susceptible to oxidative degradation.Additionally, Blueberry pigment can not dissolve in liposoluble substance, it is difficult to equably add fat-soluble
In product.The insoluble feature of unstability and fat of Blueberry pigment makes its application and popularization be very limited.
Soft capsule is a kind of preparation that at home and abroad have developed rapidly in recent years, has biological utilisation compared with other formulations
Degree is high, good airproof performance, the advantages of content is accurate.Therefore, it is to improve its stability and expand it to make to prepare Blueberry pigment soft capsule
With an effective way of scope.The Chinese patent of Patent No. ZL 201010586889.8 discloses a kind of entitled " capsanthin
The preparation method of element and the double red cellulose soft capsules of lycopene " patent document, by contents melting in oil-dissolving solvent, then
Emulsifying homogeneous obtain double red promotor compositions, then the natural red promotor composition of oily is dripped according to a conventional method by capsulation
Make or be pressed into soft capsule.The Chinese patent of Application No. 201410790794.6 discloses entitled " a kind of soft capsule and its life
Product method ", the content of the soft capsule is made up of yellow cyclopentadienyl extract, ginkgo biloba p.e, soybean oil and beeswax, and capsule gram is by bright
Glue, glycerine, water, titanium dioxide are admired and Cacao pigment composition.The soft capsule of variety classes content essentially consists in its content system
Work has different requirements, the particularly making of non-fat-soluble content.With beeswax and soybean lecithin as suspending agent and stabilizer,
Applied using colloid mill fine crankshaft technology and yet there are no report in Blueberry pigment soft capsule preparation research.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of preparation method of Blueberry pigment soft capsule, existing to solve
Blueberry pigment is difficult to equably add in fat-soluble product in technology.
In order to solve the above technical problems, the present invention provides following technical scheme：
A kind of Blueberry pigment soft capsule, the content of the soft capsule includes the component of following weight portion：
The content of capsule preferably includes the component of following weight portion：19 parts of Blueberry pigment medicinal extract, 75 parts of soybean oil, soybean
2 parts of lecithin, 4 parts of beeswax.
Wherein, the preparation method of the Blueberry pigment medicinal extract is as follows：
A () freezes blueberries 5~10 days under the conditions of -18 DEG C；
B step (a) gained blueberries are taken out and thawed 1 hour by (), add the edible alcohol of pH=3, and solid-liquid ratio is 1:10,
It is placed in 40 DEG C of thermostat water bath and extracts 120min, filter, collect filtrate, is repeated under the same terms once, will twice
Extract merges centrifugation, and rotary evaporation is concentrated to give Blueberry pigment medicinal extract.
Wherein, the softgel shell of soft capsule includes the component of following weight portion：
1 part of water
0.8~1.2 part of gelatin
0.3~0.4 part of glycerine.
The softgel shell of soft capsule preferably includes the component of following weight portion：1 part of water, 10.35 parts of gelatin, 0.351 part of glycerine.
The preparation method of above-mentioned Blueberry pigment soft capsule, comprises the following steps：
(1) prepared by content：In proportion will soybean lecithin add soybean oil in, be heated to 80 DEG C~90 DEG C, Ran Houjia
Enter beeswax to stir to being completely dissolved, Blueberry pigment medicinal extract is added after being cooled to 30 DEG C, be well mixed, cross milling treatment of colloid 2~3
Time, obtain the content of soft capsule；
(2) prepared by glue：Glue tank temperature will first be changed and be set as 90~95 DEG C, water and glycerine, waiting then are put into proportion
Glue tank is warming up to after the temperature for setting, and gelatin is put into thereto, is stirred 1 hour, is stopped 55~60 DEG C of stirring and is stood insulation
8h, or be evacuated to after glue bubble-free and stand 1~3 hour, glue is obtained；
(3) soft capsule compacting：The glue that content that step (1) is obtained, step (2) are obtained is suppressed in encapsulating machine
Into soft capsule；
(4) shape and dry：It is 20~40%, temperature soft by what is suppressed under conditions of 20~25 DEG C in relative humidity
Capsule is placed in rotating cage and shapes 1.0~2.0 hours, by the soft capsule after sizing in 20~25 DEG C of drying temperature, relative humidity 20
Under~25% airtight condition, dry 10~15 hours, that is, obtain the Blueberry pigment soft capsule.
In step (1), colloid milling time is 3~5 minutes, and rotating speed is 2000~4000r/min, and emulsification fineness is 10
~25um.
In step (3), it is 0.80~0.85mm that rubber thickness is obtained, and loading amount is the soft capsule of 400~600mg/.
In step (3), sprinkler body temperature is adjusted to 37~41 DEG C after the thickness of rubber is adjusted to 0.80~0.85mm, protected
Rotating speed is held for 2.5~4.5 revs/min, operating ambient temperature winter of encapsulating machine is 20~25 DEG C or summer is 18~20 DEG C,
Relative humidity is 20~40%.
The preparation method of Blueberry pigment soft capsule is comprised the following steps that：
(1) preparation of Blueberry pigment medicinal extract：Well-graded blueberries are freezed 5~10 days under the conditions of -18 DEG C；By gained
Blueberries take out and thaw 1 hour, add the edible alcohol of pH=3, and solid-liquid ratio is 1:10, it is placed in 40 DEG C of thermostat water bath and soaks
120min is carried, is filtered, collect filtrate, repeated under the same terms once, centrifugation will be merged by extract twice, rotary evaporation is dense
Contracting obtains Blueberry pigment medicinal extract；
(2) prepared by content：80 DEG C~90 DEG C are heated to during 1~3 part of soybean lecithin is added into 60~80 portions of soybean oils,
Add 3~5 parts of beeswaxs to stir to being completely dissolved, 15~25 parts of Blueberry pigment of gained in step (1) is added after being cooled to 30 DEG C, mix
Close it is uniform after cross milling treatment of colloid 2~3 times immediately, it is 3~5 minutes to grind the time every time, and rotating speed is 2000~4000r/min,
Emulsification fineness is 10~25um, obtains the content of soft capsule；
(3) prepared by glue：Glue tank temperature will first be changed and be set as 90~95 DEG C, then load weighted water and glycerine (water：It is sweet
Oil=(1:(0.3~0.4)) put in together, after changing glue tank and being warming up to the temperature for setting, gelatin (water is put into thereto
: gelatin=1:(0.8~1.2)), then glue bucket end cap is installed, start stirring 1 hour.It is incubated 55 as stopping stirring is latter
~60 DEG C (bung must be opened when insulation, facilitate heat to discharge outward, if do not opened, can influence the dynamic of glue
Power).Standing 1~3 is small after (now changing glue tank the inside bubble-free) or be evacuated to glue bubble-free after insulation standing 8 hours
When, glue is obtained, it is standby；
(4) soft capsule compacting：Glue in content in step (2) and step (3) is pressed into encapsulating machine
Soft capsule.Glue is warming up to 70~80 DEG C (about needing 40min) before start, the glue that will be obtained in step (3) is flowed into through sebific duct
Glue box, glue flows out to rotary drum from glue box；The content for adding step (2) to prepare in hopper simultaneously, it is 2.5 to keep rotating speed
~4.5 revs/min, sprinkler body temperature is adjusted to 37~41 DEG C after the thickness of rubber is adjusted to 0.80-0.85mm, carries out pelleting
And check rubber crack, it is determined that after, content is irrigated, loading amount is adjusted to 400-600mg/, then carries out capsule and pill compacting；It is soft
The operating ambient temperature of capsule machine is 20-25 DEG C (winter) or 18-20 DEG C (summer), and relative humidity is 20~40%；
(5) soft capsule sizing and drying：It is that 20~40%, temperature will compacting under conditions of 20~25 DEG C in relative humidity
Good soft capsule is placed in rotating cage and shapes 1.0~2.0 hours, by the soft capsule after sizing in 20~25 DEG C of drying temperature, relative
It is placed on dries under the airtight condition of humidity 20~25% and dried 10~15 hours on jiggering, obtains the soft capsule.
(6) ball is selected：Dried soft capsule is examined on lamp inspection desk and removes special-shaped ball, bubble ball, big piller, oil leak ball etc. no
Qualified soft capsule.
Blueberry pigment is made soft capsule, moisture absorption and oxidation by air can be prevented, and the existence machine of microorganism can be reduced
Can etc., content can stable for extended periods of time.Functional components therein are effectively remained, and content homogeneity is good, contains
Amount deviation is very low, and after intake, content discharges rapidly, and internal utilization rate, absorptivity is high.Can transport for a long time at ambient temperature
Defeated, preservation, so that extend the supply season of product, balance production and marketing peak, with very big market potential.
Beneficial effect：
(1) blueberry is freezed but is not crushed and extracted with acidifying edible alcohol, Blueberry pigment yield and purity are high.
(2) using soybean lecithin and beeswax as stabilizer and suspending agent, by ratio optimization, gained Blueberry pigment is soft
The uniformity of capsule 's content, good stability, are not susceptible to sedimentation layering, and good fluidity, suitable pelleting.
(3) softgel shell reasonable mixture ratio, hardness are moderate, and temperature tolerance is good, adhesion, indeformable, stable storing.
Brief description of the drawings
Fig. 1 Blueberry pigment soft capsule finished products of the present invention.
Fig. 2 is not added with the Blueberry pigment soft capsule of stabilizer and suspending agent.
Specific embodiment
According to following embodiments, the present invention may be better understood.However, as it will be easily appreciated by one skilled in the art that real
Apply the content described by example and be merely to illustrate the present invention, without should also without limitation on sheet described in detail in claims
Invention.
Embodiment 1：
(1) Blueberry pigment is extracted：
(a) pretreatment of raw material：Well-graded blueberries are freezed 5~10 days under the conditions of -18 DEG C；
B gained blueberries in step (1) are taken out and thawed 1 hour by (), add the edible alcohol of pH=3, and solid-liquid ratio is 1:
10, it is placed in 40 DEG C of thermostat water bath and extracts 120min, filter, filtrate is collected, repeated under the same terms once, by two
Secondary extract merges centrifugation, and rotary evaporation is concentrated to give Blueberry pigment medicinal extract；
(2) prepared by content：80 DEG C~90 DEG C are heated to during 1.5 parts of soybean lecithins are added into 65 portions of soybean oils, 3 are added
Part beeswax is stirred to being completely dissolved, and 15 parts of Blueberry pigment of gained in step (1) is added after being cooled to 30 DEG C, after being well mixed immediately
Milling treatment of colloid 2~3 times are crossed, the time is ground every time for 3~5 minutes, rotating speed is 2000~4000r/min, emulsification fineness is 10
~25um, obtains the content of soft capsule；
(3) prepared by glue：Glue tank temperature will first be changed and be set as 90~95 DEG C, then load weighted water and glycerine (water：It is sweet
Oil=1:0.3) put in together, wait changing after glue tank is warming up to the temperature for setting, put into thereto gelatin (water: gelatin=
1:0.8), then glue bucket end cap install, start stirring 1 hour.Stop stirring it is latter as be incubated 55~60 DEG C (insulation when
Waiting bung must open, and facilitate heat to discharge outward, if do not opened, can influence the power of glue).It is small that insulation stands 8
Shi Yihou (now changing glue tank the inside bubble-free) stands 1~3 hour after being evacuated to glue bubble-free, and glue is obtained, standby；
(4) soft capsule compacting：Glue in content in step (2) and step (3) is pressed into encapsulating machine
Soft capsule.Glue is warming up to 70~80 DEG C (about needing 40min) before start, the glue that will be obtained in step (3) is flowed into through sebific duct
Glue box, glue flows out to rotary drum from glue box；The content for adding step (2) to prepare in hopper simultaneously, it is 2.5 to keep rotating speed
~4.5 revs/min, sprinkler body temperature is adjusted to 37~41 DEG C after the thickness of rubber is adjusted to 0.80~0.85mm, is pressed
Ball simultaneously checks rubber crack, it is determined that after, content is irrigated, loading amount is adjusted to 400~600mg/, then carries out capsule and pill pressure
System；The operating ambient temperature of encapsulating machine is 20-25 DEG C (winter) or 18-20 DEG C (summer), and relative humidity is 20~40%；
(5) soft capsule sizing and drying：It is that 20~40%, temperature will compacting under conditions of 20~25 DEG C in relative humidity
Good soft capsule is placed in rotating cage and shapes 1.0~2.0 hours, by the soft capsule after sizing in 20~25 DEG C of drying temperature, relative
It is placed on dries under the airtight condition of humidity 20~25% and dried 10~15 hours on jiggering, obtains the soft capsule；
(6) ball is selected：Dried soft capsule is examined on lamp inspection desk and removes special-shaped ball, bubble ball, big piller, oil leak ball etc. no
Qualified soft capsule.
Embodiment 2:
(1) Blueberry pigment is extracted：Blueberry pigment extracts preparation method with embodiment 1.
(2) prepared by content：80 DEG C~90 DEG C are heated to during 2 parts of soybean lecithins are added into 75 portions of soybean oils, 4 parts are added
Beeswax is stirred to being completely dissolved, and 19 parts of Blueberry pigment of gained in step (1) is added after being cooled to 30 DEG C, mistake immediately after being well mixed
Milling treatment of colloid 2~3 times, ground the time for 3~5 minutes every time, and rotating speed is 2000~4000r/min, and emulsification fineness is 10~
25um, obtains the content of soft capsule；
(3) prepared by glue：Glue tank temperature will first be changed and be set as 90~95 DEG C, then load weighted water and glycerine (water：It is sweet
Oil=1:0.35) put in together, wait changing after glue tank is warming up to the temperature for setting, put into thereto gelatin (water: gelatin=
1:1), then glue bucket end cap install, start stirring 1 hour.It is incubated at 55~60 DEG C (when insulation as stopping stirring is latter
Bung must be opened, and facilitate heat to discharge outward, if do not opened, can influence the power of glue).Insulation stands 8 hours
After (now change glue tank the inside bubble-free) or stand 1~3 hour after being evacuated to glue bubble-free, glue is obtained, it is standby；
(4) soft capsule compacting：Glue in content in step (2) and step (3) is pressed into encapsulating machine
Soft capsule.Glue is warming up to 70~80 DEG C (about needing 40min) before start, the glue that will be obtained in step (3) is flowed into through sebific duct
Glue box, glue flows out to rotary drum from glue box；The content for adding step (2) to prepare in hopper simultaneously, it is 2.5 to keep rotating speed
~4.5 revs/min, sprinkler body temperature is adjusted to 37~41 DEG C after the thickness of rubber is adjusted to 0.80~0.85mm, is pressed
Ball simultaneously checks rubber crack, it is determined that after, content is irrigated, loading amount is adjusted to 400-600mg/, then carries out capsule and pill compacting；
The operating ambient temperature of encapsulating machine is 20-25 DEG C (winter) or 18-20 DEG C (summer), and relative humidity is 20~40%；
(5) soft capsule sizing and drying：It is that 20~40%, temperature will compacting under conditions of 20~25 DEG C in relative humidity
Good soft capsule is placed in rotating cage and shapes 1.0~2.0 hours, by the soft capsule after sizing in 20~25 DEG C of drying temperature, relative
It is placed on dries under the airtight condition of humidity 20~25% and dried 10~15 hours on jiggering, obtains the soft capsule；
(6) ball is selected：Dried soft capsule is examined on lamp inspection desk and removes special-shaped ball, bubble ball, big piller, oil leak ball etc. no
Qualified soft capsule.
Embodiment 3:
(1) Blueberry pigment is extracted：Blueberry pigment extracts preparation method with embodiment 1.
(2) prepared by content：80 DEG C~90 DEG C are heated to during 2.5 parts of soybean lecithins are added into 77 portions of soybean oils, are added
4.5 parts of beeswaxs are stirred to being completely dissolved, and 25 parts of Blueberry pigment of gained in step (1) are added after being cooled to 30 DEG C, after being well mixed
Milling treatment of colloid 2~3 times being crossed immediately, the time being ground every time for 3~5 minutes, rotating speed is 2000~4000r/min, emulsifies fineness
It is 10~25um, obtains the content of soft capsule；
(3) prepared by glue：Glue tank temperature will first be changed and be set as 90~95 DEG C, then load weighted water and glycerine (water：It is sweet
Oil=1:0.4) put in together, wait changing after glue tank is warming up to the temperature for setting, put into thereto gelatin (water: gelatin=
1:1.2), then glue bucket end cap install, start stirring 1 hour.Stop stirring it is latter as be incubated 55~60 DEG C (insulation when
Waiting bung must open, and facilitate heat to discharge outward, if do not opened, can influence the power of glue).It is small that insulation stands 8
Shi Yihou (now changing glue tank the inside bubble-free) stands 1~3 hour after being evacuated to glue bubble-free, and glue is obtained, standby；
(4) soft capsule compacting：Glue in content in step (2) and step (3) is pressed into encapsulating machine
Soft capsule.Glue is warming up to 70~80 DEG C (about needing 40min) before start, the glue that will be obtained in step (3) is flowed into through sebific duct
Glue box, glue flows out to rotary drum from glue box；The content for adding step (2) to prepare in hopper simultaneously, it is 2.5 to keep rotating speed
~4.5 revs/min, sprinkler body temperature is adjusted to 37~41 DEG C after the thickness of rubber is adjusted to 0.80~0.85mm, is pressed
Ball simultaneously checks rubber crack, it is determined that after, content is irrigated, loading amount is adjusted to 400-600mg/, then carries out capsule and pill compacting；
The operating ambient temperature of encapsulating machine is 20-25 DEG C (winter) or 18-20 DEG C (summer), and relative humidity is 20~40%；
(5) soft capsule sizing and drying：It is that 20~40%, temperature will compacting under conditions of 20~25 DEG C in relative humidity
Good soft capsule is placed in rotating cage and shapes 1.0~2.0 hours, by the soft capsule after sizing in 20~25 DEG C of drying temperature, relative
It is placed on dries under the airtight condition of humidity 20~25% and dried 10~15 hours on jiggering, obtains the soft capsule；
(6) ball is selected：Dried soft capsule is examined on lamp inspection desk and removes special-shaped ball, bubble ball, big piller, oil leak ball etc. no
Qualified soft capsule.
In order to investigate the influence of suspending agent, it is 1 with oil phase volume ratio to keep Blueberry pigment:4, beeswax and soybean are changed respectively
The consumption of lecithin, determines the sedimentation volume ratio of suspension.Analysis result such as table 1.As can be known from Table 1, when the use of beeswax
When amount gradually increases, suspension starts separation time and the sedimentation equilibrium time is obviously prolonged, sedimentation volume ratio increase, shows to be suspended
Liquid stability increases；When beeswax addition up to 4% or 5%, when soybean lecithin usage amount is 2%, suspension stability is best.
And found when fixed beeswax addition investigates soybean lecithin, when soybean lecithin usage amount reaches 4%, the stabilization of suspension
Property is best.In view of beeswax excessively conveying when core is denser to be unfavorable for glue and soybean lecithin can be excessively unfavorable for
Health, therefore optimum quantum of utilization selection 4% beeswax and 2% soybean lecithin.Fig. 1 is Blueberry pigment soft capsule finished product of the present invention；Fig. 2
To be not added with the Blueberry pigment soft capsule finished product of stabilizer and suspending agent, the Blueberry pigment flexible glue of stabilizer and suspending agent is not added with
Blueberry pigment is unable to Stable distritation in capsule, easily precipitation.
The suspending agent function analysis result of table 1
Claims (7)
1. a kind of Blueberry pigment soft capsule, it is characterised in that the content of the soft capsule includes the component of following weight portion：
2. Blueberry pigment soft capsule according to claim 1, it is characterised in that the preparation method of the Blueberry pigment medicinal extract
It is as follows：
A () freezes blueberries 5~10 days under the conditions of -18 DEG C；
B step (a) gained blueberries are taken out and thawed 1 hour by (), add the edible alcohol of pH=3, and solid-liquid ratio is 1:10, it is placed in
120min is extracted in 40 DEG C of thermostat water bath, is filtered, collect filtrate, repeated under the same terms once, will extracted twice
Liquid merges centrifugation, and rotary evaporation is concentrated to give Blueberry pigment medicinal extract.
3. Blueberry pigment soft capsule according to claim 1, it is characterised in that the softgel shell of soft capsule includes following weight portion
Component：
1 part of water
0.8~1.2 part of gelatin
0.3~0.4 part of glycerine.
4. the preparation method of Blueberry pigment soft capsule described in claims 1 to 3, it is characterised in that comprise the following steps：
(1) prepared by content：In proportion by soybean lecithin addition soybean oil, 80 DEG C~90 DEG C are heated to, are subsequently adding honeybee
Wax is stirred to being completely dissolved, and Blueberry pigment medicinal extract is added after being cooled to 30 DEG C, is well mixed, and crosses milling treatment of colloid 2~3 times, is obtained
To the content of soft capsule；
(2) prepared by glue：Glue tank temperature will first be changed and be set as 90~95 DEG C, water and glycerine, glue tank to be changed then are put into proportion
After being warming up to 90~95 DEG C, gelatin is put into thereto, stirred 1 hour, stop 55~60 DEG C of stirring and stand insulation 8h, or vacuumize
1~3 hour is stood after to glue bubble-free, glue is obtained；
(3) soft capsule compacting：The glue that content that step (1) is obtained, step (2) are obtained is pressed into soft in encapsulating machine
Capsule；
(4) shape and dry：It is the soft capsule that 20~40%, temperature will be suppressed under conditions of 20~25 DEG C in relative humidity
Be placed in rotating cage shape 1.0~2.0 hours, by the soft capsule after sizing 20~25 DEG C of drying temperature, relative humidity 20~
Under 25% airtight condition, dry 10~15 hours, that is, obtain the Blueberry pigment soft capsule.
5. the preparation method of Blueberry pigment soft capsule according to claim 4, it is characterised in that in step (1), colloid mill
Milling time is 3~5 minutes, and rotating speed is 2000~4000r/min, and emulsification fineness is 10~25um.
6. the preparation method of Blueberry pigment soft capsule according to claim 4, it is characterised in that in step (3), is obtained glue
Skin thickness is 0.80~0.85mm, and loading amount is the soft capsule of 400~600mg/.
7. the preparation method of Blueberry pigment soft capsule according to claim 4, it is characterised in that in step (3), capsule pressure
When processed, sprinkler body temperature is adjusted to 37~41 DEG C by the thickness of rubber after being adjusted to 0.80~0.85mm, keep rotating speed be 2.5~
4.5 revs/min, operating ambient temperature winter of encapsulating machine is 20~25 DEG C or summer is 18~20 DEG C, and relative humidity is 20
~40%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710072468.5A CN106880046A (en) | 2017-02-10 | 2017-02-10 | A kind of Blueberry pigment soft capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710072468.5A CN106880046A (en) | 2017-02-10 | 2017-02-10 | A kind of Blueberry pigment soft capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106880046A true CN106880046A (en) | 2017-06-23 |
Family
ID=59179887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710072468.5A Pending CN106880046A (en) | 2017-02-10 | 2017-02-10 | A kind of Blueberry pigment soft capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106880046A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259238A (en) * | 2018-11-18 | 2019-01-25 | 福建省安职教育服务有限公司 | A kind of preparation method of seal oil auxiliary blood fat reducing soft capsule |
| CN110585261A (en) * | 2019-09-25 | 2019-12-20 | 新疆超越歆生物科技有限公司 | Process preparation method of sea-buckthorn blueberry instant soft capsule |
| CN114304626A (en) * | 2022-01-05 | 2022-04-12 | 盖茨汉普(武汉)植物应用研究有限公司 | MitoQ blueberry anthocyanin soft capsule preparation formula and preparation process |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101778576A (en) * | 2007-03-15 | 2010-07-14 | 欧博康有限公司 | stabilized anthocyanin compositions |
| JP4606444B2 (en) * | 2007-08-21 | 2011-01-05 | アピ株式会社 | Anthocyanin-containing composition for oral administration and method for producing the same |
| CN104055122A (en) * | 2014-07-09 | 2014-09-24 | 江西维莱营健高科有限公司 | Haematococcus pluvialis and blueberry extract soft capsules and preparation method thereof |
| CN104147081A (en) * | 2014-08-20 | 2014-11-19 | 哈尔滨顺亿堂医药生物科技开发有限公司 | Blueberry lutein soft capsule for improving eyesight and manufacturing method thereof |
| CN104224890A (en) * | 2014-07-29 | 2014-12-24 | 中宏生物工程有限责任公司 | Lutein soft capsule and preparation method thereof |
| CN104257727A (en) * | 2014-09-09 | 2015-01-07 | 哈尔滨中泰医药有限公司 | Soft capsule for relieving visual fatigue and processing method |
-
2017
- 2017-02-10 CN CN201710072468.5A patent/CN106880046A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101778576A (en) * | 2007-03-15 | 2010-07-14 | 欧博康有限公司 | stabilized anthocyanin compositions |
| JP4606444B2 (en) * | 2007-08-21 | 2011-01-05 | アピ株式会社 | Anthocyanin-containing composition for oral administration and method for producing the same |
| CN104055122A (en) * | 2014-07-09 | 2014-09-24 | 江西维莱营健高科有限公司 | Haematococcus pluvialis and blueberry extract soft capsules and preparation method thereof |
| CN104224890A (en) * | 2014-07-29 | 2014-12-24 | 中宏生物工程有限责任公司 | Lutein soft capsule and preparation method thereof |
| CN104147081A (en) * | 2014-08-20 | 2014-11-19 | 哈尔滨顺亿堂医药生物科技开发有限公司 | Blueberry lutein soft capsule for improving eyesight and manufacturing method thereof |
| CN104257727A (en) * | 2014-09-09 | 2015-01-07 | 哈尔滨中泰医药有限公司 | Soft capsule for relieving visual fatigue and processing method |
Non-Patent Citations (1)
| Title |
|---|
| 孟宪军等: "响应面法优化蓝莓花色苷提取工艺的研究", 《食品工业科技》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259238A (en) * | 2018-11-18 | 2019-01-25 | 福建省安职教育服务有限公司 | A kind of preparation method of seal oil auxiliary blood fat reducing soft capsule |
| CN110585261A (en) * | 2019-09-25 | 2019-12-20 | 新疆超越歆生物科技有限公司 | Process preparation method of sea-buckthorn blueberry instant soft capsule |
| CN114304626A (en) * | 2022-01-05 | 2022-04-12 | 盖茨汉普(武汉)植物应用研究有限公司 | MitoQ blueberry anthocyanin soft capsule preparation formula and preparation process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhao et al. | Enzyme-assisted extraction of astaxanthin from Haematococcus pluvialis and its stability and antioxidant activity | |
| CN104887583B (en) | A kind of preparation method of cellulose base Polyphenols natural anti-oxidation compound | |
| CN106880046A (en) | A kind of Blueberry pigment soft capsule and preparation method thereof | |
| CN104546538B (en) | A kind of VC-VE liposomes of Chitosan-coated and its preparation method and application | |
| CN101897440A (en) | Coenzyme Q10 composite soft capsule and preparation method thereof | |
| CN105639647B (en) | A kind of vitamin, carotenoid pulvis and its preparation method and application | |
| CN113712144A (en) | Preparation method of rose geranium essential oil microcapsule with good oxidation resistance and bacterial inhibition performance | |
| CN105726482A (en) | Xanthophyll nano-liposome and preparation method thereof | |
| CN106723031A (en) | Matrimony vine zeaxanthin, lutein, the preparation method of vitamin E soft capsule | |
| CN108670882A (en) | A kind of edible lipstick and preparation method thereof | |
| CN107674451B (en) | A kind of Blueberry pigment microcapsules and preparation method thereof | |
| CN109646425B (en) | Preparation method and application of H1, H2 or J type astaxanthin aggregate water dispersion system | |
| CN108741080A (en) | A kind of microalgae DHA- anthocyanidin biphase liposome and preparation method thereof | |
| CN102579303A (en) | Green alga liposome and preparation method and application thereof | |
| CN112618583A (en) | Preparation method of antrodia camphorata dropping pill | |
| CN108968069A (en) | Alleviate asthenopia, improves eyesight, is anti-oxidant, the composite soft capsule and preparation method of protection retina | |
| CN104774483A (en) | Preparation method of micro-nano-corn yellow pigment | |
| CN102641311B (en) | Kiwi fruit seed oil liposome oral liquid and preparation method thereof | |
| CN108157943A (en) | The preparation method of glossy ganoderma spore powder with crushed sporoderm tree peony seed oil composite soft capsule | |
| CN106138123A (en) | A kind of oil of Nitraria seeds microcapsule and preparation method thereof | |
| CN102772389A (en) | Water-soluble vitamin E soft capsule and preparation method thereof | |
| CN1759738A (en) | A kind of health bee products with radiation-resisting functional | |
| CN109568293A (en) | A kind of preparation method of astaxanthin biological microcapsules | |
| CN109419774A (en) | The Simple film of anthocyanin lipidosome disperses preparation method in a kind of blueberry | |
| CN103783349A (en) | Process for preparing honeycomb polyphenol extractive microcapsule by adopting spray drying method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170623 |
|
| RJ01 | Rejection of invention patent application after publication |