CN110585261A - Process preparation method of sea-buckthorn blueberry instant soft capsule - Google Patents
Process preparation method of sea-buckthorn blueberry instant soft capsule Download PDFInfo
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Abstract
A process for preparing a sea-buckthorn and blueberry instant soft capsule comprises the following steps of taking blueberries and sea-buckthorn as raw materials, extracting effective ingredients of processed blueberry dregs by using water as an extraction medium through ultrasonic low-temperature reflux, collecting filtrate, clarifying by using a micro-membrane filter, concentrating by using a reverse osmosis membrane, and preparing blueberry instant powder by using vacuum freeze drying: extracting effective components in the sea-buckthorn branches and leaves by an ultrasonic-assisted extraction method twice in the front and back, collecting filtrate, performing micro-membrane filtration and reverse osmosis concentration on the filtrate, performing freeze drying on the filtrate to obtain sea-buckthorn instant tea powder, and mixing the sea-buckthorn instant tea powder and the sea-buckthorn instant tea powder in a proper ratio to obtain a content. The soft capsule shell is made by pressing gelatin, glycerin and purified water with a soft capsule machine. The anthocyanin contained in the blueberry has the functions of penetrating into cells to protect cell membranes from being oxidized by free radicals, can penetrate through a blood brain barrier, can protect cranial nerves from being oxidized, can stabilize brain tissue functions, and protects the brain from being damaged by harmful chemical substances and toxins.
Description
Technical Field
The invention relates to a soft capsule health food and a production and preparation method thereof, in particular to a process preparation method of a sea-buckthorn and blueberry instant soft capsule which takes blueberries and sea-buckthorn as main raw materials.
Background
Sea buckthorn is a precious economic forest tree species containing the most natural vitamins in the world at present. Besides being eaten fresh, the sea buckthorn fruit can also be processed into fruit juice, fruit wine, jam, preserved fruit, jelly, beverage, health care products and the like. With the acceleration of the life rhythm and the increase of working pressure of people, people in sub-health are increased continuously, the immunity function of the organism is also reduced, and the symptoms of easy fatigue of the body, inappetence, headache, insomnia and the like appear. In order to reduce the side effects of the health care product as much as possible, people often supplement natural health care food properly to improve the self immune function. The anthocyanin contained in the blueberry has the functions of penetrating into cells to protect cell membranes from being oxidized by free radicals, has strong antioxidation and antiallergic functions, can pass through a blood brain barrier, can protect cranial nerves from being oxidized, can stabilize brain tissue functions, and protects the brain from being damaged by harmful chemical substances and toxins. After the anthocyanin in the blueberries is eaten, people feel clear-headed and sleep is effectively improved. The sea-buckthorn fruit is rich in nutrition, and according to the determination that the sea-buckthorn fruit contains active substances such as various vitamins, fatty acids, trace elements, linoleic acid, sea-buckthorn flavone, superoxide and the like and various amino acids required by a human body, the sea-buckthorn fruit can enhance the immune function of the human body.
Disclosure of Invention
The invention provides a process preparation method of a sea-buckthorn blueberry instant soft capsule.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a technical preparation method of a sea-buckthorn and blueberry instant soft capsule comprises a capsule shell and a sea-buckthorn instant powder content arranged in the capsule shell, wherein the capsule shell is pressed by a soft capsule machine by adopting a pressing method, blueberries and sea-buckthorns are taken as raw materials, and the preparation method of the technical preparation method of the sea-buckthorn and blueberry instant soft capsule comprises the following steps:
(1) extracting effective components of blueberry processing crushed slag by using water as an extraction medium and adopting ultrasonic low-temperature reflux, controlling the temperature below 60 ℃ in the whole process, extracting twice in the front and back directions, collecting filtrate, and preparing blueberry soluble powder by using micro-membrane filtration clarification, reverse osmosis membrane concentration and vacuum freeze drying;
(2) extracting effective components in the sea-buckthorn branches and leaves by an ultrasonic-assisted extraction method twice in front and at back, collecting filtrate, filtering by a micro-membrane, concentrating by reverse osmosis, and then freeze-drying to obtain sea-buckthorn soluble tea powder;
(3) mixing and blending the blueberry soluble powder and the sea-buckthorn soluble tea powder in a proper proportion to obtain a content for later use;
(4) weighing purified water and glycerol according to a proportion, firstly introducing the purified water into a gelatin melting tank, heating to 40-50 ℃, then adding gelatin and glycerol into the gelatin melting tank, stirring and heating, heating to 60-70 ℃, stirring and dissolving for 30-45 min;
(5) after the gelatin is uniformly stirred and completely dissolved, starting a vacuum pump when the temperature of the gelatin liquid in the tank reaches 65-70 ℃, and defoaming the gelatin liquid in the tank;
(6) cooling the glue solution meeting the requirements to 50-55 ℃, and putting the glue solution into a heat-preserving container for preparing soft capsules;
(7) and (4) putting the content obtained in the step (3) and the glue solution obtained in the step (6) into a soft capsule machine to be pressed into a shape, washing off residual oil on the shell of the capsule by using 95% edible alcohol, then shaping and drying in a rolling cage of a drying machine, and finally removing the capsules which have defects and do not meet the requirements.
Preferably, the temperature of the soft capsule preparation operation room is controlled to be 18-26 ℃, the relative humidity is less than or equal to 50%, the setting time is 2-4 h, the setting temperature is 18-26 ℃, the relative humidity during setting is less than or equal to 50%, the drying time is 24-48 h, the drying temperature is 20-30 ℃, and the relative humidity during drying is less than or equal to 30%.
Preferably, the defective and unsatisfactory capsule comprises a capsule having a shape, having air bubbles, leaking oil or sticking.
Preferably, the particle size of the blueberry soluble powder is less than or equal to 10 mu m, and the solubility is more than or equal to 98 percent; the sea-buckthorn tea powder contains more than or equal to 10g/100g of flavone, more than or equal to 6g/100g of plant crude polysaccharide and more than or equal to 100g/100g of anthocyanin.
Compared with the prior art, the preparation method of the sea-buckthorn blueberry instant soft capsule has the beneficial effects that:
the nutritional values of Xinjiang special blueberry and sea buckthorn are effectively combined, and the preparation method is a pure natural extraction preparation method, so that the concept of green and health is reflected. The preparation method of the sea-buckthorn and blueberry instant soft capsule prepared by the invention can be taken with warm water, the content of the capsule is tea powder particles after superfine grinding, the particle size is less than or equal to 10 mu m, the solubility is more than or equal to 98%, and the product has the health-care functions of regulating the immune system, benefiting sleep, resisting fatigue, preventing aging, preventing cardiovascular and cerebrovascular diseases, reducing cholesterol and lowering blood pressure.
Detailed Description
The sea-buckthorn and blueberry instant soft capsule comprises a capsule shell and a sea-buckthorn instant powder content arranged in the capsule shell, wherein the capsule shell is formed by pressing through a soft capsule machine by adopting a pressing method, the content takes blueberries and sea-buckthorn as raw materials, and meanwhile, momordica grosvenori or sugar additives are added for improving the taste.
The blueberry contains rich purplish red pigment in fruits, is very soluble in water, and belongs to natural water-soluble anthocyanin flavonoids. In the classic works of Tibetan medicines for treating heart heat, anthocyanin contained in blueberry is the most effective natural antioxidant, so that the senescence of human cell tissues is delayed, the young state of people is kept, and the life of people is prolonged. The anthocyanin in the blueberries can also remove free radicals in human bodies, can effectively prevent the generation of cancer cells and even can prevent the cancer cells from diffusing smoothly, thereby achieving the purpose of cancer prevention and resistance.
The sea-buckthorn contains various biochemical components (flavonoids, fats, various amino acids, organic acids, unsaturated fatty acids), abundant vitamins and the like, and has good effects on the aspects of body immune function, oxidation resistance and the like.
(1) The method has the advantages that the effective components in the blueberries are extracted by water, the natural pigment components of the blueberries are efficiently prepared by adopting the technologies of macroporous adsorption resin purification, low-temperature concentration and the like, the technology is advanced and environment-friendly, and the problems of high energy consumption, environmental pollution and the like caused by the organic solvent extraction crystallization technology are solved.
(2) The ultrasonic-assisted enzyme technology is used for extracting the active ingredients of the sea buckthorn tea, so that the extraction time is shortened, the extraction temperature is reduced, and the extraction rate is improved; the application of the membrane technology provides guarantee for the aroma retention of the clarified tea juice and the concentrated tea juice, and improves the product quality.
(3) The application of the freeze drying technology solves the problems of flavonoid oxidation, fragrant smell and the like at high temperature, and ensures the product quality.
(4) The research and development of the product belong to the deep processing of Xinjiang special agricultural products, the added value of the product is improved, the deep processing industrial chain of Xinjiang agricultural and sideline products is extended, the blank of high-end products of Xinjiang agricultural products is filled, and the product has important significance for promoting the rapid growth of Xinjiang agricultural economy.
Blueberry and sea buckthorn instant powder;
leaching blueberry and sea buckthorn instant powder;
the flavor of the blueberry and sea buckthorn instant powder is greatly related to the extracted components, but some components are easy to extract (such as aroma components and fresh taste components), and some components are difficult to extract. Therefore, the proper extraction preparation method can not only improve the extraction rate, but also improve the product quality.
The extraction preparation method comprises the following steps: the single-barrel intermittent extraction method is preferred, and during extraction, tea leaves weighed in advance can be poured into an extraction barrel lined with a cloth bag, a certain proportion of boiling water is added, and the tea leaves are covered and extracted.
The extraction times are as follows: if the ratio of 1: 8, extracting the tea water for 2 times, wherein the first extraction time is 15min, and the second extraction time is 10min, so that the water extract can be basically extracted; however, because the raw materials are different in age and tenderness, the first extraction rate is different, the rule is that the extraction amount is correspondingly improved along with the reduction of the tenderness of the raw materials; generally, the low-grade tea is extracted once.
Extraction time: generally, the relation between the extraction time and the leaching amount is not obvious, the broken pieces of sweater are used as raw materials, the tea-water ratio is 1: 12, the leaching amount of leaching for 10min is 68.17 percent, and the leaching amount is 69.94 percent after leaching for 40 min. Therefore, the extraction time has little influence after reaching certain requirements. On the contrary, the tea leaves in a hydrothermal stuffy state for a long time can cause the color and luster of the extracting solution to be yellow, the fragrance to be stuffy and cooked, and the quality of the finished product to be poor. Therefore, the extraction time is preferably 10-15 min.
Filtering blueberry and sea buckthorn instant powder
Covering and leaching for 10-15min, discharging the liquid, and after the extracting solution is basically filtered out, transferring the bag-attached residues into a dryer for centrifugal coarse filtration; the tea-water ratio during extraction is 1: preferably 6 to 12.
Purification of blueberry and sea buckthorn instant powder
The purification is the process of impurity removal and sediment removal, a small amount of suspended matters of tea fragments exist in the extract, and a small amount of cold insoluble substances exist in the extract after the extract is cooled, and the substances are required to be removed. At present, the purification preparation method mainly comprises two methods: one is physical preparation method, such as centrifugation, filtration, etc.; the other is a chemical preparation method, which mainly aims at that the precipitation part of the cold insoluble substance is subjected to proper chemical treatment to promote the re-dissolution of the substance.
Concentration of blueberry and sea-buckthorn instant powder
The purified extract is relatively dilute, so the extract needs to be concentrated, and the solid content is increased to about 20 to 40 percent. Therefore, the drying efficiency is improved, and the low-density particle blueberry and sea buckthorn freeze-dried instant powder is obtained. The concentration preparation method can adopt high-efficiency vacuum concentration, freezing concentration or heating concentration, etc.
Generally, the tea is concentrated by heat, the tea fragrance is easy to update, and the tea soup is easy to brown. Therefore, in recent years, research has been carried out on applying a normal temperature membrane concentration technique, which is very effective, and the membrane concentration is to select a semipermeable membrane with a porosity that is practically permeable only to water molecules but not to dry matter components of tea leaves, so as to reduce water content to a certain degree and achieve the purpose of concentration.
In order to completely reserve and utilize main nutrient components and bioactive components of the blueberries and the sea-buckthorns, the taste of the medicine is covered, the medicine is convenient to take, and the medicine is popularized to wide applicable people. The soft capsule is packed in a soft capsule shell, and the preparation method of the soft capsule is required to be the minimum volume and the maximum content of the filler. The soft capsule shell package has good sealing property and portability, is convenient for storage, transportation and eating, and has the characteristics of good stability, remarkable curative effect and high productivity.
The preparation method of the soft capsule shell in the technical preparation method of the sea buckthorn and blueberry instant soft capsule comprises the following steps:
(1) weighing purified water and glycerol according to a proportion, firstly introducing the purified water into a gelatin melting tank, heating to 40-50 ℃, then adding gelatin and glycerol into the gelatin melting tank, stirring and heating, heating to 60-70 ℃, stirring and dissolving for 30-45 min;
(2) after the gelatin is uniformly stirred and completely dissolved, starting a vacuum pump when the temperature of the gelatin liquid in the tank reaches 65-70 ℃, and defoaming the gelatin liquid in the tank;
(3) cooling the glue solution meeting the requirements to 50-55 ℃, and putting the glue solution into a heat-preserving container for preparing soft capsules;
(4) and (4) putting the content and the glue solution obtained in the step (3) into a soft capsule machine to be pressed into a shape, washing off residual oil on the shell of the capsule by using 95% edible alcohol, then shaping and drying in a rolling cage of a drying machine, and finally removing the capsule which has abnormal shape, bubbles, oil leakage or adhesion and the like and does not meet the requirements.
Wherein the temperature of the soft capsule preparation operation room is controlled to be 18-26 ℃, the relative humidity is less than or equal to 50%, the setting time is 2-4 h, the setting temperature is 18-26 ℃, the relative humidity during setting is less than or equal to 50%, the drying time is 24-48 h, the drying temperature is 20-30 ℃, and the relative humidity during drying is less than or equal to 30%.
The soft capsule has thick shell comprising glycerin, gelatin, etc. and no air permeability, so that it is excellent preparation for preventing oxidation of medicine, and the content needs heating and drying treatment during preparation. The medicine which is unstable in moist heat or easy to oxidize can be made into soft capsule. Not only can ensure the retention of volatile components in the medicinal materials, but also can avoid the escape of the preparation after the preparation is placed, and improve the quality and the curative effect of the medicine.
The invention utilizes the branches and leaves of the blueberry fruits and the sea buckthorn fruits, effectively combines the nutritional values of the Xinjiang specialty blueberry and the sea buckthorn fruits, and prepares the Xinjiang specialty blueberry and the sea buckthorn fruits by using a pure natural extraction preparation method, embodies the concept of green and health, and avoids resource waste. The blueberry and sea-buckthorn freeze-dried instant powder is prepared by refining by an ultrafine grinding technology, the particle size of the blueberry soluble powder is less than or equal to 10 mu m, the solubility is more than or equal to 98 percent, the content of flavone in the sea-buckthorn soluble tea powder is more than or equal to 10g/100g, the content of crude plant polysaccharide is more than or equal to 6g/100g, and the content of anthocyanin is more than or equal to 100g/100 g; the taste is fine and smooth, and the fragrance is mellow; the nutritional values of the blueberries and the sea buckthorns are reflected.
Finally, it should be noted that: the above examples are merely illustrative of the technical solutions of the present invention, and not limitative thereof; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (4)
1. A process preparation method of a sea-buckthorn and blueberry instant soft capsule comprises a capsule shell and a sea-buckthorn instant powder content arranged in the capsule shell, and is characterized in that the capsule shell is formed by pressing a soft capsule machine by a pressing method, the content takes blueberries and sea-buckthorn as raw materials, and the preparation method comprises the following steps:
(1) extracting effective components of crushed blueberry processing residues by using water as an extraction medium and adopting ultrasonic low-temperature reflux, controlling the temperature below 60 ℃ in the whole process, extracting twice in the front and back process, collecting filtrate, and preparing blueberry soluble powder by using micro-membrane filtration clarification, reverse osmosis membrane concentration and vacuum freeze drying;
(2) extracting effective components in the sea-buckthorn branches and leaves by an ultrasonic-assisted extraction method twice in front and at back, collecting filtrate, filtering by a micro-membrane, concentrating by reverse osmosis, and then freeze-drying to obtain sea-buckthorn soluble tea powder;
(3) mixing and blending the blueberry soluble powder and the sea-buckthorn soluble tea powder in a proper proportion to obtain a content for later use;
(4) weighing purified water and glycerol according to a proportion, firstly introducing the purified water into a gelatin melting tank, heating to 40-50 ℃, then adding gelatin and glycerol into the gelatin melting tank, stirring and heating, heating to 60-70 ℃, stirring and dissolving for 30-45 min;
(5) after the gelatin is uniformly stirred and completely dissolved, starting a vacuum pump when the temperature of the gelatin liquid in the tank reaches 65-70 ℃, and defoaming the gelatin liquid in the tank;
(6) cooling the glue solution meeting the requirements to 50-55 ℃, and putting the glue solution into a heat-preserving container for preparing soft capsules;
(7) and (4) putting the content obtained in the step (3) and the glue solution obtained in the step (6) into a soft capsule machine to be pressed into a shape, washing off residual oil on the shell of the capsule by using 95% edible alcohol, then shaping and drying in a rolling cage of a drying machine, and finally removing the capsules which have defects and do not meet the requirements.
2. The process preparation method of the seabuckthorn and blueberry instant soft capsule as claimed in claim 1, wherein the temperature of the soft capsule preparation operation room is controlled to be 18-26 ℃, the relative humidity is less than or equal to 50%, the setting time is 2-4 hours, the setting temperature is 18-26 ℃, the relative humidity during setting is less than or equal to 50%, the drying time is 24-48 hours, the drying temperature is 20-30 ℃, and the relative humidity during drying is less than or equal to 30%.
3. The process for preparing the seabuckthorn and blueberry instant soft capsule as claimed in claim 1, wherein the defective and unsatisfactory capsule comprises a capsule with abnormal shape, bubbles, oil leakage or adhesion.
4. The technological preparation method of the seabuckthorn and blueberry instant soft capsule as claimed in claim 1, wherein the particle size of the blueberry soluble powder is less than or equal to 10 μm, and the solubility is more than or equal to 98%; the sea-buckthorn tea powder contains more than or equal to 10g/100g of flavone, more than or equal to 6g/100g of plant crude polysaccharide and more than or equal to 100g/100g of anthocyanin.
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1683397A (en) * | 2005-02-28 | 2005-10-19 | 高原圣果沙棘制品有限公司 | Process for extracting protein, total flavone and super oxide dismutase from sea-buckthorn fresh branch and leaf |
CN1759745A (en) * | 2005-10-11 | 2006-04-19 | 辽宁红树莓产业发展有限公司 | Hygienical functional food of blue berry and preparation method |
CN105796617A (en) * | 2016-04-28 | 2016-07-27 | 上海春芝堂生物制品有限公司 | Fructus hippophae and ganodorma lucidum soft capsule and preparation method of fructus hippophae and ganodorma lucidum soft capsule |
CN106107394A (en) * | 2016-06-15 | 2016-11-16 | 安徽徽王食品有限公司 | A kind of blue berry hippophae rhamnoides beverage of facilitating digestion and preparation method thereof |
CN106880046A (en) * | 2017-02-10 | 2017-06-23 | 合肥师范学院 | A kind of Blueberry pigment soft capsule and preparation method thereof |
CN108902405A (en) * | 2018-06-26 | 2018-11-30 | 新疆超越歆生物科技有限公司 | The manufacture craft of lycium ruthenicum sea-buckthorn freeze-dried instant powder |
-
2019
- 2019-09-25 CN CN201910909596.XA patent/CN110585261A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1683397A (en) * | 2005-02-28 | 2005-10-19 | 高原圣果沙棘制品有限公司 | Process for extracting protein, total flavone and super oxide dismutase from sea-buckthorn fresh branch and leaf |
CN1759745A (en) * | 2005-10-11 | 2006-04-19 | 辽宁红树莓产业发展有限公司 | Hygienical functional food of blue berry and preparation method |
CN105796617A (en) * | 2016-04-28 | 2016-07-27 | 上海春芝堂生物制品有限公司 | Fructus hippophae and ganodorma lucidum soft capsule and preparation method of fructus hippophae and ganodorma lucidum soft capsule |
CN106107394A (en) * | 2016-06-15 | 2016-11-16 | 安徽徽王食品有限公司 | A kind of blue berry hippophae rhamnoides beverage of facilitating digestion and preparation method thereof |
CN106880046A (en) * | 2017-02-10 | 2017-06-23 | 合肥师范学院 | A kind of Blueberry pigment soft capsule and preparation method thereof |
CN108902405A (en) * | 2018-06-26 | 2018-11-30 | 新疆超越歆生物科技有限公司 | The manufacture craft of lycium ruthenicum sea-buckthorn freeze-dried instant powder |
Non-Patent Citations (6)
Title |
---|
XIAOXIAO2018: ""沙棘蓝莓汁功效"", 《大众养生网》 * |
孟胜男等: "《药剂学》", 31 January 2016, 中国医药科技出版社 * |
广东省食品药品监督管理局组织编写: "《保健食品GMP实用指南》", 30 April 2007, 中国轻工业出版社 * |
张军等: "沙棘蓝莓复合格瓦斯饮料的研制 ", 《国际沙棘研究与开发》 * |
樊梓鸾等: "5种野生浆果的抗氧化和抗细胞增殖活性 ", 《食品科学》 * |
段丽丽等: "沙棘、蓝莓粉复合沙棘油软糖的研制 ", 《中国食物与营养》 * |
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