CN106138123A - A kind of oil of Nitraria seeds microcapsule and preparation method thereof - Google Patents
A kind of oil of Nitraria seeds microcapsule and preparation method thereof Download PDFInfo
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- CN106138123A CN106138123A CN201610521671.1A CN201610521671A CN106138123A CN 106138123 A CN106138123 A CN 106138123A CN 201610521671 A CN201610521671 A CN 201610521671A CN 106138123 A CN106138123 A CN 106138123A
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- oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
Abstract
The invention discloses a kind of oil of Nitraria seeds microcapsule, it is to be prepared from by the supplementary material of following weight proportioning: oil of Nitraria seeds 1～9 parts, hydroxypropyl beta cyclodextrin 8～60 parts, sodium caseinate 1.0～4.5 parts, stabilizer 0.01 part～0.05 part.Microcapsule adjuvant of the present invention selects proper, and preparation technology repeatability is good；Quality evaluation result shows, gained microcapsule clathrate stable, uniform particle sizes, has high saturation factor and stable fuel load, and has preferable outward appearance and good stability, beneficially industrialization and large-scale production.
Description
Technical field
The present invention relates to a kind of oil of Nitraria seeds microcapsule and preparation method thereof, belong to field of medicaments.
Background technology
Nitraria Nitraria is the raw or super non-irrigated raw Typical Desert plant of zygophyllaceae drought, is the excellent shrub checked winds and fixed drifting sand.
Berry of nitraria tangutorum bobr is studied discovery, and it has higher economy and medical value, the most carries out in food, field of health care products
Exploitation application.When utilizing berry of nitraria tangutorum bobr, meeting output a large amount of Cortex Acanthopanacis Radicis seed, studies have reported that kind of a Cortex Acanthopanacis Radicis seed oil content reaches 11%
～13%, wherein contain abundant health-care components, including linoleic acid and some other unsaturated fatty acid, have bigger equally
Value of exploiting and utilizing: linoleic acid is the necessary aminoacid of one that human body can not synthesize, owing to it has reduction blood cholesterol levels, in advance
Preventing arteriosclerosis etc. act on, and receive much concern；Other unsaturated fatty acid such as polyunsaturated fatty acid can improve immunologic function,
Can significantly reduce fasting plasma triacylglycerol concentration, the effect to reducing postprandial lipid metabolism level is the strongest；Daily intake 0.8～
The linolenic acid of 1.5g can significantly reduce the danger of myocardial infarction, has special preventive effect to coronary heart disease.
But, just because of oil of Nitraria seeds contains multiple active skull cap components, bring not to the application of oil of Nitraria seeds
Just: the existence of a large amount of active skull cap components, make the aerial oil of Nitraria seeds of exposure easily become sour, go bad, reduce and even make it
Lose original function；It addition, the oil of Nitraria seeds of liquid carries, transports, stores, uses all inconveniences.How to make oil of Nitraria seeds
Keep its health care more muchly, utilize this valuable natural resources more easily, be an important class in research at present
Topic.
Microcapsule technology is that one utilizes naturally occurring or synthetic macromolecular material (common name wall material) by solid or liquid (common name core
Material) encapsulation becomes a diameter of a few micrometers to the technology of the tiny capsules of hundreds of micron.Microcapsule possesses advantages below: 1, from form
Liquid, gas transition can be become solid；2, cyst wall can be protected and isolate the material easily reacted to each other so that it is can be stably
And deposit；3, the release of core material can be controlled as required；4, color, taste, toxicity etc. can be shielded.But, micro encapsulation exists more
Technological difficulties, especially wall material select and with the ratio of core, generally require the physicochemical property according to core-clad material and carry out greatly
Amount experimentation just can determine that, otherwise there will be the problems such as microencapsulated forms not rounding, adhesion and core-clad material content is too low, it is difficult to
Obtain the microcapsule of satisfactory quality.It addition, the preparation technology of microcapsule is the most crucial.Tang Jun etc. are to fish oil micro-capsule
Preparation technology investigates, as a result, it was confirmed that the multiple conditional parameter in microcapsule preparation process, such as high pressure homogenize pressure, air-out
The factor such as temperature, inlet temperature all microcapsule quality can be made a significant impact (Tang Jun etc. Responds Surface Methodology optimize fish oil microcapsule
The research [J] of preparation technology. Food Additives Used in China, 2010,142～147).
Therefore it provides a kind of superior in quality oil of Nitraria seeds microcapsule, become a problem demanding prompt solution.
Summary of the invention
It is an object of the invention to provide a kind of oil of Nitraria seeds microcapsule and preparation method thereof.
The invention provides a kind of oil of Nitraria seeds microcapsule, it is to be prepared from by the supplementary material of following weight proportioning: white
Thorn seed oil 1～9 part, HP-β-CD 8～60 parts, sodium caseinate 1.0～4.5 parts, stabilizer 0.01 part～0.05
Part.
Further, described stabilizer is in gelatin, arabic gum, albumin, starch, chitosan, alginate
One or more.
Preferably, it is the preparation being prepared from by the supplementary material of following weight proportioning: oil of Nitraria seeds 9 parts, hydroxy propyl-Beta-
Cyclodextrin 60 parts, sodium caseinate 4.5 parts, 0.05 part of gelatin.
Further, described oil of Nitraria seeds derives from Nitraria Nitraria plant seed.
Further, described Nitraria Nitraria plant is Nitraria tangutorum Nitraria tangutorumBor..
Further, in described oil of Nitraria seeds, unsaturated fatty acid content is 41.6%～80.3%w/w.
Further, described oil of Nitraria seeds passes through supercritical CO2Extraction prepares.
Further, described supercritical CO2Extraction conditions is: extraction kettle pressure is 20～35Mpa, temperature 45 ± 1 DEG C；Point
From I pressure 8～12Mpa, temperature 58 ± 1 DEG C；Separate II pressure 6～8MPa, temperature 38 ± 1 DEG C, CO2Flow is 40-80L/h,
Extraction 2-4h, obtains oil of Nitraria seeds.
The invention provides the preparation method of a kind of described oil of Nitraria seeds microcapsule, comprise the steps:
A, taking HP-β-CD and sodium caseinate, the distillation with 60 ± 2 DEG C of 0.5～2 times of volume is water-soluble
Solving, add 0.1～0.5%w/v aqueous gelatin solution in solution, keeping solution temperature is 60 ± 2 DEG C, stirs, obtains wall material
Solution；
B, the wall material solution of a step is mixed with oil of Nitraria seeds, become with rotating speed 12000rpm～20000rpm high speed shear
Emulsion, gained emulsion is in 30-55 DEG C of homogenizing 2 times, and homogenization pressure is 20～30Mpa；Sterilizing；
C, the emulsion after sterilizing is spray-dried, temperature of charge 50～60 DEG C, intake air temperature 160～180 DEG C,
Air outlet 85～100 DEG C, nebulizer 24000 ± 10r/min, charging rate 40 ± 2mL/min, to obtain final product.
Further, b step uses the instantaneous heat sterilization of superhigh temperature, heating-up temperature 110～130 DEG C, time 5～10s.
The invention provides a kind of oil of Nitraria seeds microcapsule and preparation technology thereof.Microcapsule adjuvant of the present invention selects proper,
Preparation technology repeatability is good；Quality evaluation result shows, gained microcapsule clathrate stable, and uniform particle sizes has high saturation factor
With stable fuel load, and there is preferable outward appearance and good stability, beneficially industrialization and large-scale production.
Obviously, according to the foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, without departing from
Under the present invention above-mentioned basic fundamental thought premise, it is also possible to make the amendment of other various ways, replace or change.
The detailed description of the invention of form by the following examples, remakes the most specifically the foregoing of the present invention
Bright.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below.All based on foregoing of the present invention
The technology realized belongs to the scope of the present invention.
Detailed description of the invention
The raw material, the equipment that use in the specific embodiment of the invention are known product, obtain by buying commercially available prod.
The assay method of microcapsule oil content is with reference to NY/T 1285-2007 " the mensuration remnants method of oilseed oil content "
The 1-4 page described method.
The preparation of embodiment 1 oil of Nitraria seeds of the present invention microcapsule
1, pretreatment of raw material
Nitraria tangutorum (Nitraria tangutorum Bor.) seed is dried, pulverizes, cross 40 mesh sieves, standby.
2, supercritical CO2Extraction oil of Nitraria seeds
The Cortex Acanthopanacis Radicis seed sample that 380.0g pulverizes is loaded in 1L extraction kettle every time and carry out supercritical CO2Fluid extraction, extraction
Taking still pressure is 20～35MPa, temperature 45 ± 1 DEG C；Separate I pressure 8～12Mpa, temperature 58 ± 1 DEG C；Separate II pressure 6～
8MPa, temperature 38 ± 1 DEG C, CO2Flow is 40-80L/h, extracts 2-4h, accesses seed oil every 30min, finally gives Semen Nitraria schoberi
Oil samples 55.3g.
3, microencapsulation wall material prepares
HP-β-CD (HP-β-CD) 80.0g, caseinic acid 10.0g is weighed, with the steaming of 60 ± 2 DEG C in beaker
Distilled water 100ml is dissolved, and adds 0.2 dissolved～0.3%w/w edible Gelatinum oxhide aqueous solution 100ml, as surely in wall material solution
Determine agent, utilize microwave extraction instrument auxiliary to stir, and to keep solution temperature be 60 ± 2 DEG C.
4, seed oil mixes with wall material
Take oil of Nitraria seeds 10.0g, be slowly added in above-mentioned wall material solution.
5, emulsifying, homogenizing
Above-mentioned mixed liquor high speed shear (rotating speed 12000rpm～20000rpm) is become emulsion, and gained emulsion is in 30-
55 DEG C carry out homogenizing 2 times, and homogenization pressure is 20～30Mpa.
6, sterilizing
By after above-mentioned gained homogenizing emulsion use the instantaneous heat sterilization of superhigh temperature, heating-up temperature 110～130 DEG C, time
Between 5～10s.50～60 DEG C it are cooled to after sterilizing.
7, it is spray-dried
Emulsion after gained sterilizing is spray-dried, temperature of charge 50～60 DEG C, intake air temperature 160～180 DEG C,
Air outlet 85～100 DEG C, nebulizer 24000 ± 10r/min, charging rate 40 ± 2mL/min, obtain oil of Nitraria seeds of the present invention micro-
Capsule powders A 103.8g, microcapsule oil content is 11.2%.
The preparation of embodiment 2 oil of Nitraria seeds of the present invention microcapsule
1, pretreatment of raw material
Nitraria tangutorum (Nitraria tangutorum Bor.) seed is dried, pulverizes, cross 50 mesh sieves, standby.
2, supercritical CO2Extraction oil of Nitraria seeds
The Cortex Acanthopanacis Radicis seed sample loading 5L extraction kettle pulverized by 1000g carries out supercritical CO2Fluid extraction, extraction kettle pressure
Power is 20～35MPa, temperature 45 ± 1 DEG C；Separate I pressure 8～12Mpa, temperature 58 ± 1 DEG C；Separate II pressure 6～8MPa, temperature
Spend 38 ± 1 DEG C, CO2Flow is 40-80L/h, extracts 2-4h, accesses seed oil every 30min, finally gives oil of Nitraria seeds sample
167.2g。
3, microencapsulation wall material prepares
HP-β-CD (HP-β-CD) 300.0g, caseinic acid 30.0g is weighed, with 60 ± 2 DEG C in beaker
Distilled water 400ml dissolves, and adds the 0.1%w/w edible Gelatinum oxhide aqueous solution 100ml dissolved in wall material solution, as stable
Agent, utilizes microwave extraction instrument auxiliary to stir, and to keep solution temperature is 60 ± 2 DEG C.
4, seed oil mixes with wall material
Take oil of Nitraria seeds 30.0g, be slowly added in above-mentioned wall material solution.
5, emulsifying, homogenizing
Above-mentioned mixed liquor high speed shear (rotating speed 12000rpm～20000rpm) is become emulsion, and gained emulsion is in 30-
55 DEG C carry out homogenizing 2 times, and homogenization pressure is 20～30Mpa.
6, sterilizing
By after above-mentioned gained homogenizing emulsion use the instantaneous heat sterilization of superhigh temperature, heating-up temperature 110～130 DEG C, time
Between 5～10s.50～60 DEG C it are cooled to after sterilizing.
7, it is spray-dried
Emulsion after gained sterilizing is spray-dried, temperature of charge 50～60 DEG C, intake air temperature 160～180 DEG C,
Air outlet 85～100 DEG C, nebulizer 24000 ± 10r/min, charging rate 40 ± 2mL/min, obtain oil of Nitraria seeds of the present invention micro-
Capsule powders B 341.6g, microcapsule oil content is 10.7%.
The preparation of embodiment 3 oil of Nitraria seeds of the present invention microcapsule
1, pretreatment of raw material
Nitraria tangutorum (Nitraria tangutorum Bor.) seed is dried, pulverizes, cross 60 mesh sieves, standby.
2, supercritical CO2Extraction oil of Nitraria seeds
The Cortex Acanthopanacis Radicis seed sample loading 20L extraction kettle pulverized by 5000g carries out supercritical CO2Fluid extraction, extraction kettle
Pressure is 20～35MPa, temperature 45 ± 1 DEG C；Separate I pressure 8～12Mpa, temperature 58 ± 1 DEG C；Separate II pressure 6～8MPa,
Temperature 38 ± 1 DEG C, CO2Flow is 40-80L/h, extracts 2-4h, accesses seed oil every 30min, finally gives oil of Nitraria seeds sample
825.3g。
3, microencapsulation wall material prepares
HP-β-CD (HP-β-CD) 600.0g, caseinic acid 45.0g is weighed, with 60 ± 2 DEG C in beaker
Distilled water 800ml dissolves, and adds the 0.5%w/w edible Gelatinum oxhide aqueous solution 100ml dissolved in wall material solution, as stable
Agent, utilizes microwave extraction instrument auxiliary to stir, and to keep solution temperature is 60 ± 2 DEG C.
4, seed oil mixes with wall material
Take oil of Nitraria seeds 90.0g, be slowly added in above-mentioned wall material solution.
5, emulsifying, homogenizing
Above-mentioned mixed liquor high speed shear (rotating speed 12000rpm～20000rpm) is become emulsion, and gained emulsion is in 30-
55 DEG C carry out homogenizing 2 times, and homogenization pressure is 20～30Mpa.
6, sterilizing
By after above-mentioned gained homogenizing emulsion use the instantaneous heat sterilization of superhigh temperature, heating-up temperature 110～130 DEG C, time
Between 5～10s.50～60 DEG C it are cooled to after sterilizing.
7, it is spray-dried
Emulsion after gained sterilizing is spray-dried, temperature of charge 50～60 DEG C, intake air temperature 160～180 DEG C,
Air outlet 85～100 DEG C, nebulizer 24000 ± 10r/min, charging rate 40 ± 2mL/min, obtain oil of Nitraria seeds of the present invention micro-
Capsule powders C 741.9g, microcapsule oil content is 12.1%.
The preparation of embodiment 4 oil of Nitraria seeds of the present invention microcapsule
1, microencapsulation wall material prepares
HP-β-CD (HP-β-CD) 80.0g, caseinic acid 10.0g is weighed, with the steaming of 60 ± 2 DEG C in beaker
Distilled water 100ml is dissolved.
2, stabilizer is added
0.1% dissolved～1%w/w arabic gum (or albumin or chitosan or Sargassum is added in wall material solution
Hydrochlorate) aqueous solution 100ml, as stabilizer, utilize microwave extraction instrument auxiliary to stir, and to keep solution temperature be 60 ± 2
℃。
3, seed oil mixes with wall material
Take oil of Nitraria seeds 10.0g, be slowly added in above-mentioned wall material solution.
4, emulsifying, homogenizing
Above-mentioned mixed liquor high speed shear (rotating speed 12000rpm～20000rpm) is become emulsion, and gained emulsion is in 30-
55 DEG C carry out homogenizing 2 times, and homogenization pressure is 20～30Mpa.
5, sterilizing
By after above-mentioned gained homogenizing emulsion use the instantaneous heat sterilization of superhigh temperature, heating-up temperature 110～130 DEG C, time
Between 5～10s.50～60 DEG C it are cooled to after sterilizing.
6, it is spray-dried
Emulsion after gained sterilizing is spray-dried, temperature of charge 50～60 DEG C, intake air temperature 160～180 DEG C,
Air outlet 85～100 DEG C, nebulizer 24000 ± 10r/min, charging rate 40 ± 2mL/min, obtain oil of Nitraria seeds of the present invention micro-
Capsule powders D 105.1g, microcapsule oil content is 10.4%.
Beneficial effects of the present invention is proved below by way of experimental example.
Experimental example 1 oil of Nitraria seeds of the present invention microscapsule powder A-D quality evaluation result
1, oil of Nitraria seeds microscapsule powder clathrate stable
Weigh 5.0g oil of Nitraria seeds microscapsule powder at random to be paved with in the 180mm culture dish being lined with filter paper, culture dish is put
Be placed in hermetic container, in 1,3,5,8,10d observe in each culture dish oil of Nitraria seeds mimeograph accounting on filter paper, evaluate oil of Nitraria seeds micro-
The clathrate stable of capsule powders, the results are shown in Table 1.
Table 1 oil of Nitraria seeds microscapsule powder clathrate stable
Result shows, in observation time, oil of Nitraria seeds microscapsule powder mimeograph accounting is respectively less than 5.0%, and this is described
Bright Semen Nitraria schoberi oil microcapsule powder has good clathrate stable；Wherein, according to the microscapsule powder C oil of embodiment 3 preparation
Print accounting is minimum, shows that its clathrate stable is optimal.
2, oil of Nitraria seeds Microcapsules Size distribution
The oil of Nitraria seeds microscapsule powder A-D of the present invention of equivalent is uniformly mixed, weighs 1.0g at random, be placed in band vernier calliper
Observe and add up the particle diameter of about 500 microspheres under the microscope (× 100 times) of chi, the results are shown in Table 2.
Table 2 oil of Nitraria seeds microscapsule powder particle diameter is distributed
Result shows, oil of Nitraria seeds microscapsule powder particle diameter of the present invention is normal distribution, major part particle diameter be distributed in 30～
Between 60 μm, particle size distribution range is narrower, and mean diameter is 44.38 ± 4.18 μm.
3, oil of Nitraria seeds microcapsule inclusion rate and fuel load
Weigh oil of Nitraria seeds microscapsule powder 10.0g at random, it is to avoid loss, accurately weighed after, by its with filter paper wrap up, put
In apparatus,Soxhlet's, being injected by the chloroform of 50mL in flask, installation extraction element, on water-bath, is heated to reflux 2h, makes micro-
Capsule destroys completely, (microscopy exists without microcapsule), reclaims chloroform, falls remaining oily liquid in flask in beaker, is placed in
Vacuum drying oven is waved to without chloroform taste for 50 DEG C, weighs, both obtain the quality of oil of Nitraria seeds.According to the lower micro-glue of column count oil of Nitraria seeds
The inclusion rate of capsule powder and fuel load, the results are shown in Table 3:
Oil mass/throwing oil mass × 100% in inclusion rate %=microcapsule
Oil mass/microcapsule gross weight × 100% in fuel load %=microcapsule
Table 3 oil of Nitraria seeds microcapsule inclusion rate and fuel load
Result shows, embodiment 1～4 gained microscapsule powder inclusion rate all can stably reach more than 95%, and fuel load
All can be stable at about 11.1%, illustrate that oil of Nitraria seeds microcapsule of the present invention has higher saturation factor and fuel load；Wherein, root
Microscapsule powder C fuel load, inclusion rate according to embodiment 3 preparation are the highest.It addition, result above also illustrates invention formulation formula
And stable preparation process, repeatability are well.4, oil of Nitraria seeds microcapsule stability is investigated
Try with pharmaceutical preparation stability with reference to Pharmacopoeia of People's Republic of China (version two in 2010) annex XIX C crude drug
Test guideline, investigate oil of Nitraria seeds microscapsule powder (uniformly being mixed by the oil of Nitraria seeds microscapsule powder A-D of equivalent) respectively
And oil of Nitraria seeds, respectively take 3 parts, every part of 20.0g, seal and be placed in medicine stability test case, respectively at 60 DEG C, relative humidity
90% (temperature 25 DEG C) and illumination 4500lx place 10d under the conditions of irradiating, and in sampling in the 5th day and the 10th day, measure peroxide respectively
Before and after change value (with reference to GB/T 5538-2005 " animal and plant fat determination of POV " the 1st～4 also institute's support method), specimen test
Weight and cosmetic variation, the results are shown in Table 4.
Table 4 microcapsule stability factors influencing
Result shows, Cortex Acanthopanacis Radicis microscapsule powder is more stable compared with oil of Nitraria seeds, shows that peroxide value is by illumination, temperature and wet
Degree impact is the least compared with oil of Nitraria seeds, and its moisture absorption deliquescence performance meets stability requirement, under the conditions of strong irradiation, cosmetic variation without
Significant change.
Summary quality evaluation result understands, and the microscapsule powder quality that the present invention provides is good, is in particular in: bag
Close stable, uniform particle sizes, there is high saturation factor and stable fuel load, and there is preferable outward appearance and good stability.
Claims (10)
1. an oil of Nitraria seeds microcapsule, is characterized in that: it is to be prepared from by the supplementary material of following weight proportioning: oil of Nitraria seeds
1～9 part, HP-β-CD 8～60 parts, sodium caseinate 1.0～4.5 parts, stabilizer 0.01 part～0.05 part.
2. oil of Nitraria seeds microcapsule as claimed in claim 1, is characterized in that: described stabilizer is gelatin, arabic gum, white
One or more in albumen, starch, chitosan, alginate.
3. oil of Nitraria seeds microcapsule as claimed in claim 2, is characterized in that: it is to be prepared by the supplementary material of following weight proportioning
Preparation: oil of Nitraria seeds 9 parts, HP-β-CD 60 parts, sodium caseinate 4.5 parts, 0.05 part of gelatin.
4. the oil of Nitraria seeds microcapsule as described in claims 1 to 3 any one, is characterized in that: described oil of Nitraria seeds source
In Nitraria Nitraria plant seed.
5. oil of Nitraria seeds microcapsule as claimed in claim 4, is characterized in that: described Nitraria Nitraria plant is that Tang is ancient
Extra white thorn Nitraria tangutorum Bor..
6. oil of Nitraria seeds microcapsule as claimed in any one of claims 1 to 5, wherein, is characterized in that: insatiable hunger in described oil of Nitraria seeds
It is 41.6%～80.3%w/w with content of fatty acid.
7. oil of Nitraria seeds microcapsule as claimed in claim 6, is characterized in that: described oil of Nitraria seeds passes through supercritical CO2Extraction system
For obtaining.
8. oil of Nitraria seeds microcapsule as claimed in claim 7, is characterized in that: described supercritical CO2Extraction conditions is: extraction kettle
Pressure is 20～35Mpa, temperature 45 ± 1 DEG C；Separate I pressure 8～12Mpa, temperature 58 ± 1 DEG C；Separate II pressure 6～8MPa,
Temperature 38 ± 1 DEG C, CO2Flow is 40-80L/h, extracts 2-4h, obtains oil of Nitraria seeds.
9. a preparation method for oil of Nitraria seeds microcapsule described in claim 1～8 any one, is characterized in that: include as follows
Step:
A, take HP-β-CD and sodium caseinate, dissolve with the distilled water of 60 ± 2 DEG C of 0.5～2 times of volume, to
Adding 0.1～0.5%w/v aqueous gelatin solution in solution, keeping solution temperature is 60 ± 2 DEG C, stirs, obtains wall material solution；
B, the wall material solution of a step is mixed with oil of Nitraria seeds, become emulsus with rotating speed 12000rpm～20000rpm high speed shear
Liquid, gained emulsion is in 30-55 DEG C of homogenizing 2 times, and homogenization pressure is 20～30Mpa；Sterilizing；
C, the emulsion after sterilizing is spray-dried, temperature of charge 50～60 DEG C, intake air temperature 160～180 DEG C, air-out
85～100 DEG C of mouth, nebulizer 24000 ± 10r/min, charging rate 40 ± 2mL/min, to obtain final product.
10. preparation method as claimed in claim 8, is characterized in that: b step uses the instantaneous heat sterilization of superhigh temperature, heating temperature
Spend 110～130 DEG C, the time 5～10s.
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Cited By (3)
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| CN108851082A (en) * | 2018-07-12 | 2018-11-23 | 青海大学 | A kind of Berry plant oil micro-capsule and preparation method thereof |
| CN113854464A (en) * | 2021-09-26 | 2021-12-31 | 哈工大机器人南昌智能制造研究院 | Citrus essential oil capsule and preparation method thereof |
| CN115553466A (en) * | 2022-09-30 | 2023-01-03 | 南京益唯森生物科技有限公司 | Nitraria seed oil microcapsule powder containing flax polypeptide and preparation method thereof |
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| CN113854464A (en) * | 2021-09-26 | 2021-12-31 | 哈工大机器人南昌智能制造研究院 | Citrus essential oil capsule and preparation method thereof |
| CN115553466A (en) * | 2022-09-30 | 2023-01-03 | 南京益唯森生物科技有限公司 | Nitraria seed oil microcapsule powder containing flax polypeptide and preparation method thereof |
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