CN105077268A - Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation - Google Patents

Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation Download PDF

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Publication number
CN105077268A
CN105077268A CN201510406625.2A CN201510406625A CN105077268A CN 105077268 A CN105077268 A CN 105077268A CN 201510406625 A CN201510406625 A CN 201510406625A CN 105077268 A CN105077268 A CN 105077268A
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vitamin
soft capsule
oil
plant extracts
preparation
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CN105077268B (en
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张涛
张国栋
张兴
商琛栋
夏旭东
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IVC Nutrition Corp
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IVC Nutrition Corp
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention relates to a soft capsule preparation containing multivitamins, plant extracts and microelements and a preparation method of the soft capsule preparation. The preparation comprises the components of beta-carotene oil, vitamin C, vitamin D oil, vitamin E oil, B-group vitamins, plant extracts, calcium carbonate, magnesium carbonate, microelements, phosphatide, beeswax and soybean oil. The invention provides the soft capsule preparation which can simultaneously complement the multivitamins, the plant extracts and the microelements for consumers, the proportions of the components in the soft capsule preparation is adjusted to the best, health requirements of human bodies in modern society are fully considered, the formula is scientific in design, the purpose of comprehensively supplementing nutrition can be realized, and the use is convenient. The preparation method of the soft capsule preparation is simple, and the soft capsule preparation contains varied nutrient components, such as minerals, and is not layered in a content solution. The quality of the prepared products is stable, and the soft capsule is good in mouth feel, is favorable for effective absorption in intestinal tracts, and is suitable for industrialized production.

Description

A kind of soft capsule preparation containing multivitamin and plant extracts and trace element and preparation method thereof
Technical field
The present invention relates to the preparing technical field of nutraceutical, specifically, relate to a kind of soft capsule preparation containing multivitamin and plant extracts and trace element and preparation method thereof.
Background technology
In recent years, because improving constantly with the functional inspection of nutrient of medical level is increasingly complete, the health check-up report of various deficiency disease obtains paying attention to more and more widely of various circles of society.It should be noted that biological substrate is different in the requirement of different developmental stages to nutrition especially, sometimes quite responsive, if undersupply or supply unreasonable, will the various deficiency diseases causing living organism be easy to.Nutritional deficiency, also known as " subalimentation ", refers to energy that body obtains from food, nutrient can not meet somagenic need, thus impact growth, grows or the phenomenon of physiological function.In prior art, for deficiency disease safeguard procedures mainly: be on the one hand measured by regular dietary survey, physique and relevant physiology, biochemical indicator detection find and prevent in advance; Matrix is carried out to the supplementary to reach timely protection of the nutraceutical such as multivitamin mineral matter by regular on the other hand.
The multivitamin mineral preparations formulation being applicable to deficiency disease in existing consumer goods market is mainly tablet, in order to ensure that the compressibility of tablet, aesthetic property and some physical index with the addition of the auxiliary material of about 20-50% in formula Design process, comprise disintegrant, lubricant, filler, colouring agent, anticaking agent etc., and some auxiliary material long-term taking knows from experience the certain side effect of generation to people; Have minority manufacturer that the dosage form design of this preparation has been become hard capsule in order to the kind reducing auxiliary material reduces product with consumption to the side effect that human body produces, but because toxic capsule event, this dosage form product create certain impact in the heart consumer.Soft capsule preparation containing multivitamin and plant extracts and trace element on domestic market does not also have, its main cause is that product Middle nutrition composition is more, Study on influencing factors more complicated between each composition, general enterprise does not have energy and strength to be engaged in the research activity, simultaneously due to the problem of production technology, some mineral compositions contained in soft capsule, if process bad meeting to cause comparatively serious lamination and Seepage, thus limit the further research and development of soft capsule in this type of formulation art.Therefore, developing a kind of soft capsule preparation containing multivitamin and plant extracts and trace element and preparation method thereof is the current problem that will study.
Summary of the invention
In order to solve the technical problem existed in the prior art mentioned in above-mentioned background technology, the invention provides a kind of soft capsule preparation containing multivitamin and plant extracts and trace element and preparation method thereof, the formula Design science of this soft capsule preparation, nutrition arrangement are reasonable, preparation method's products obtained therefrom quality is comparatively stable, can solve the lamination problem of mineral matter and other components in soft capsule preparation and the leakage problems of product simultaneously.
The technical solution adopted for the present invention to solve the technical problems is: a kind of soft capsule preparation containing multivitamin and plant extracts and trace element, and according to weight percent meter, said preparation comprises following component:
Beta carotene oil 0.5-5.0%, vitamin C 5.0-20.0%, vitamin D oil 0.01-0.05%, vitamin E oil 5.0-10.0%, B family vitamin 5.0-15.0%, plant extracts 5.0-20.0%, calcium carbonate 10-20%, magnesium carbonate 1.0-5.5%, micro-0.5-5.0%, phosphatidase 0 .5-4.0%, beeswax 0.2-5.0%, soybean oil 30.0-50.0%.
B family vitamin, vitamin D oil, vitamin E oil, various trace elements must be come from regulation in GB14880 " national food safety standard food enrichment uses standard " to allow in the fortification immunomodulator compounds source list of use.
Further, described vitamin C is one or more the mixing in vitamine C sodium, calcium ascorbate, vitamin C potassium or vitamin C magnesium, and vitamin D oil is vitamin D 2or vitamin D 3one in oil.
Further, described vitamin B complex is Cobastab 1, Cobastab 2, Cobastab 3, Cobastab 5, Cobastab 6, Cobastab 7(biotin), Cobastab 9(folic acid), Cobastab 12, choline, one or more mixing in inositol or p-aminobenzoic acid (PABA).
Further, described plant extracts is one or more the mixing in citrus bioflavonoids, fructus rosae extract, acerola concentrate extract, Extraction of rutin thing, officinale root extract or inulin.
Further, described trace element is the combination of microelement pre-mix material and micro-monomer, microelement pre-mix material is the compound of one or more components in copper, iodine, manganese, potassium, chromium, molybdenum or selenium and auxiliary material maltodextrin, and micro-monomer is the combination according to percentage by weight 0.2-0.75%:0.2-0.5% of ferrous fumarate and zinc oxide.
Contain a preparation method for the soft capsule preparation of multivitamin and plant extracts and trace element, this preparation method comprises the following steps:
(1) according to weight percent meter, the following component of precise:
Beta carotene oil 0.5-5.0%, vitamin C 5.0-20.0%, vitamin D oil 0.01-0.05%, vitamin E oil 5.0-10.0%, B family vitamin 5.0-15.0%, plant extracts 5.0-20.0%, calcium carbonate 10-20%, magnesium carbonate 1.0-5.5%, micro-0.5-5.0%, phosphatidase 0 .5-4.0%, beeswax 0.2-5.0%, soybean oil 30.0-50.0%, also cross 100 mesh sieves by each solid powder crushing material;
(2) in solid powder material, choose the material that consumption is minimum, make by the method for equal increments doubly loose, then add the solid powder material of all the other each formula ratios, fully mix, and cross 100 mesh sieves, obtain premix A;
(3) soybean oil of formula ratio is heated to more than 60 DEG C, add the beeswax of formula ratio and stir, after beeswax dissolves completely, stop heating and stir, cool to room temperature, then adding phosphatide, beta carotene oil, oily, the vitamin E oil of vitamin D of formula ratio, be stirred to evenly and slowly add premix A, limit edged stirs, and after material mixes completely, crosses twice colloid mill, obtain the content of soft capsule preparation, stand for standby use;
(4) according to weight percent meter, the following glue component of precise: glycerine 15-20%, purified water 32-41%, titanium dioxide 0.1-0.3%, yellow ferric oxide 0.1-0.3%, gelatin 40-50%; Take the G & W (can reserve and rinse colloid mill for the later stage a little) of formula ratio herein, titanium dioxide, the yellow ferric oxide of formula ratio is added successively after being mixed by G & W, cross No. two to three colloid mills, mixed liquor is heated to 80 ~ 90 DEG C, the gelatin adding formula ratio is stirred to gelatin and dissolves completely and blend of colors evenly stops heating afterwards, the glue of soft capsule can be obtained, be incubated for subsequent use;
(5) glue of the content of step (3) gained and step (4) gained is suppressed capsule and pill on soft capsule press, pellet press rotating speed 2.0 revs/min, sprinkler body temperature keeps 41-43 DEG C, rubber thickness is 0.8mm, loading amount is 1184-1376mg/ grain, and inspection is checked in timing.The capsule and pill pressed enters in sizing rotating cage, through cleaning, drying, sterilizing, packaging into products after sizing.
The special herb ingredients added in technical scheme of the present invention, as citrus bioflavonoids, fructus rosae extract, acerola concentrate extract, Extraction of rutin thing, officinale root extract and inulin, wherein, citrus bioflavonoids is strong anti-oxidizing compounds, cool in nature lightly seasoned, the effect that there is certain step-down fat-reducing and effectively suppress spur to grow; Fructus rosae extract contains the plurality of active ingredients such as saponin, VC, polyphenol, there are anti-ageing, antifatigue, radioresistance, anti anoxia, removing thrombus significantly, hypotensive, anti-cancer, for cancer, body-building and tonifying yang, brain, the effect of promoting longevity, energy reinforcing spleen to promote digestion, promoting blood circulation for regulating menstruation, improving water flood, astringe the lung to stop cough, can be used for improving indigestion, poor appetite, abdominal distention, diarrhoea, irregular menstruation and dysmenorrhoea; Acerola concentrate extract is rich in vitamin C, vitamin A, B 1, B 2, E, P, niacin, the anti-ageing factor, calcium, iron, zinc, the multiple nutrients material such as potassium and protein, high nutritive value, citrin wherein can prevent vitamin C oxidized and be damaged, strengthen absorption and the utilizing status of VC, remove the free radical produced in physical activity and the effect effectively delayed senility; Extraction of rutin thing has the function of cooling blood and hemostasis, clearing liver-fire, can be used for reducing blood fat and cholesterol, effectively prevents and treats the inflammation that cerebral hemorrhage, hypertension, retinal hemorrhage, purple scar or various acute bleeding cause; Officinale root extract main component is the peppery alcohol of 6-ginger, 6-shogaol, the peppery alcohol of 8-ginger and the peppery alcohol of 10-ginger, have stomach invigorating anti-gastric-ulcer, cholagogic, protect the liver, cardiac stimulant, Antiaggregating activity on platelet, anti-corona, antitumor, CNS inhibition, develop immunitypty, antibacterial, desinsection, anti-inflammatory effect, also there is stronger oxidation resistance; Inulin is the deposit polysaccharide in plant, is mainly derived from plant, has and controls blood fat, reduces blood sugar, promotes mineral absorption and prevent the effect of constipation.
Beneficial effect: compared with prior art, the present invention is directed to consumer and provide a kind of soft capsule preparation that simultaneously can supplement multivitamin, plant extracts and trace element, and the ratio of each component in this soft capsule preparation is adjusted to the best, take into full account the health demand of modern society, formula Design science, nutrition arrangement are reasonable, the object comprehensively supplemented the nutrients can be reached, use more for convenience; Preparation method is simple for this soft capsule preparation, the multiple nutritional components such as the mineral matter wherein contained are not stratified in content solution, products obtained therefrom steady quality, and the mouthfeel of soft capsule is better, also be comparatively conducive to effective absorption of enteron aisle, be suitable for the large production of heavy industrialization.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail, but the present invention is not limited to following specific embodiment.
Embodiment 1
Contain a preparation method for the soft capsule preparation of multivitamin and plant extracts and trace element, this preparation method comprises the following steps:
(1) according to weight percent meter, the following component of precise:
Beta carotene oil 0.781%, calcium ascorbate 9.666%, vitamin D 3oil 0.039%, vitamin E oil 7.813%, vitamin B complex 12.612%, plant extracts 14.063%, calcium carbonate 13.209%, magnesium carbonate 5.389%, ferrous fumarate 0.734%, zinc oxide 0.25%, microelement pre-mix material 0.977%, phosphatidase 2 .0%, beeswax 1.0% and soybean oil 31.467%; Each solid powder crushing material is also crossed 100 mesh sieves;
Title Consumption mg/ grain Ratio % Remarks
Beta carotene oil 10.00 0.781
Calcium ascorbate 123.72 9.666
Vitamin D 3Oil 0.50 0.039
Vitamin E oil 100.00 7.813
B family vitamin 161.44 12.612
Plant extracts 180.00 14.063
Calcium carbonate 169.08 13.209
Magnesium carbonate 68.98 5.389
Ferrous fumarate 9.40 0.734
Zinc oxide 3.20 0.250
Microelement pre-mix material 12.50 0.977
Phosphatide 25.60 2.000
Beeswax 12.80 1.000
Soybean oil 402.78 31.467
Add up to 1280.00 100.000
Described B family vitamin is filled a prescription shown in table composed as follows;
Title Consumption mg/ grain Remarks
Cobastab 1 74.02 Thiamine mononitrate
Cobastab 2 10.00 Riboflavin
Cobastab 3 10.00 Niacinamide
Cobastab 5 10.88 Calcium pantothenate
Cobastab 6 12.16 Puridoxine hydrochloride
Cobastab 7 0.01 Biotin
Choline bitartrate 24.30
Inositol 10.00
P-aminobenzoic acid 10.00
Cobastab 9 0.06 Folic acid
Cobastab 12 0.01 Cyanocobalamin
Add up to 161.44
Described plant extract composition formula is as shown in the table:
Title Consumption mg/ grain Remarks
Citrus bioflavonoids 40.00
Fructus rosae powder extracts 40.00
Acerola concentrate extract 20.00 17% vitamin C
Rutin 20.00
Officinale root extract 20.00
Inulin 40.00
Add up to 180.00
Described microelement pre-mix material formula is as shown in the table:
(2) in solid powder material, choose the material that consumption is minimum, make by the method for equal increments doubly loose, then add the solid powder material of all the other each formula ratios, fully mix, and cross 100 mesh sieves, obtain premix A;
(3) soybean oil of formula ratio is heated to more than 60 DEG C, add the beeswax of formula ratio and stir, after beeswax dissolves completely, stop heating and stir, cool to room temperature, then adding phosphatide, beta carotene oil, oily, the vitamin E oil of vitamin D of formula ratio, be stirred to evenly and slowly add premix A, limit edged stirs, and after material mixes completely, crosses twice colloid mill, obtain the content of soft capsule preparation, stand for standby use;
(4) according to weight percent meter, precise glue component, take the G & W (can reserve and rinse colloid mill for the later stage a little) of formula ratio herein, titanium dioxide, the yellow ferric oxide of formula ratio is added successively after being mixed by G & W, cross No. two to three colloid mills, mixed liquor is heated to 80 ~ 90 DEG C, the gelatin adding formula ratio is stirred to gelatin and dissolves completely and blend of colors evenly stops heating afterwards, the glue of soft capsule can be obtained, be incubated for subsequent use, described glue formula is:
Glue is filled a prescription Consumption mg/ part Ratio %
Gelatin 100.00 45.24％
Glycerine 40.00 18.10％
Titanium dioxide 0.50 0.23％
Yellow ferric oxide 0.50 0.23％
Purified water 80.00 36.20％
Add up to 221.00 100.00％
(5) glue of the content of step (3) gained and step (4) gained is suppressed capsule and pill on soft capsule press, pellet press rotating speed 2.0 revs/min, sprinkler body temperature keeps 41-43 DEG C, rubber thickness is 0.8mm, loading amount is 1184-1376mg/ grain, and inspection is checked in timing.The capsule and pill pressed enters in sizing rotating cage, through cleaning, drying, sterilizing, packaging into products after sizing.
Embodiment 2
Contain a preparation method for the soft capsule preparation of multivitamin and plant extracts and trace element, this preparation method is with embodiment 1, and microelement pre-mix material and glue are filled a prescription the same, and dosage contents and glue comprise following component:
Name of material Consumption (mg/ grain) Ratio % Remarks
Beta carotene oil 10.000 0.781
Vitamin D 3Oil 0.550 0.043
Synthesising complex E oil 100.000 7.813
Calcium ascorbate 185.580 14.498 Cross 100 mesh sieves
VB 1 61.680 4.819
VB 2 10.000 0.781
Niacinamide 10.000 0.781
Calcium pantothenate 12.000 0.938
VB 6 12.160 0.938
Biotin 0.010 0.001
Choline bitartrate 24.300 1.898
Inositol 10.000 0.781
P-aminobenzoic acid 10.000 0.781
Folic acid 0.080 0.006
VB 12 0.020 0.001
Citrus bioflavonoids 60.000 4.688 Cross 100 mesh sieves
Fructus rosae extract 20.000 1.563 Cross 100 mesh sieves
Acerola concentrate extract 10.000 0.781 Cross 100 mesh sieves
Rutin 10.000 0.781 Cross 100 mesh sieves
Calcium carbonate 208.240 16.269 Cross 100 mesh sieves
Magnesium carbonate 57.600 4.500 Cross 100 mesh sieves
Ferrous fumarate 7.500 0.586
Zinc oxide 3.200 0.250
Microelement pre-mix material 15.000 1.172
Phosphatide 25.600 2.000
Beeswax 12.800 1.000
Soybean oil 401.280 31.538
Add up to 1280.000 100.000
Embodiment 3
Contain a preparation method for the soft capsule preparation of multivitamin and plant extracts and trace element, this preparation method is with embodiment 1, and microelement pre-mix material and glue are filled a prescription the same, and dosage contents and glue comprise following component:
Name of material With (mg/ grain) Ratio Remarks
Beta carotene oil 10.000 0.781
Vitamin D 3Oil 0.330 0.026
Synthesising complex E oil 200.000 15.625
Vitamine C sodium 150.00 11.719 Cross 100 mesh sieves
Thiamine hydrochloride 24.680 1.928
Riboflavin 8.000 0.625
Niacinamide 8.000 0.625
Calcium pantothenate 9.600 0.750
Puridoxine hydrochloride 9.730 0.760
Biotin 0.010 0.001
Choline bitartrate 19.440 1.519
Inositol 8.000 0.625
P-aminobenzoic acid 8.000 0.625
Folic acid 0.060 0.005
Cyanocobalamin 0.030 0.002
Citrus bioflavonoids 80.000 6.250 Cross 100 mesh sieves
Officinale root extract 40.000 3.125 Cross 100 mesh sieves
Inulin 20.000 1.563 Cross 100 mesh sieves
Rutin 20.000 1.563 Cross 100 mesh sieves
Calcium carbonate 166.250 12.988 Cross 100 mesh sieves
Magnesium carbonate 38.400 3.000 Cross 100 mesh sieves
Ferrous fumarate 17.500 1.367
Zinc oxide 6.250 0.4988
Microelement pre-mix material 10.000 0.781
Phosphatide 12.800 1.000
Beeswax 6.400 0.500
Soybean oil 404.920 31.759
Add up to 1280.000 100.000
Embodiment 4
Contain a preparation method for the soft capsule preparation of multivitamin and plant extracts and trace element, this preparation method is with embodiment 1, and microelement pre-mix material and glue are filled a prescription the same, and dosage contents and glue comprise following component:
Name of material Consumption (mg/ grain) Ratio % Remarks
Beta carotene oil 10.000 0.781
Vitamin D 3Oil 0.330 0.026
Natural complex E oil 150.000 11.719
Vitamin C 150.000 11.719
Thiamine mononitrate 24.680 1.928
Riboflavin 8.000 0.625
Niacinamide 8.000 0.625
Calcium pantothenate 9.600 0.750
Puridoxine hydrochloride 9.730 0.760
Choline bitartrate 19.440 1.519
Inositol 8.000 0.625
P-aminobenzoic acid 8.000 0.625
Citrus bioflavonoids 80.000 6.250 85%, 100 mesh sieves are crossed
Acerola concentrate extract 20.000 1.563
Inulin 30.000 2.344 Cross 100 mesh sieves
Calcium carbonate 200.000 15.625 Cross 100 mesh sieves
Magnesium carbonate 60.000 4.688 Cross 100 mesh sieves
Ferrous fumarate 17.500 1.367
Zinc oxide 6.250 0.488
Microelement pre-mix material 18.000 1.406
Phosphatide 25.600 2.000
Beeswax 12.800 1.000
Soybean oil 404.070 31.568
Add up to 1280.000 100.000
Embodiment 5
Contain a preparation method for the soft capsule preparation of multivitamin and plant extracts and trace element, this preparation method is with embodiment 1, and microelement pre-mix material and glue are filled a prescription the same, and dosage contents and glue comprise following component:
Name of material Consumption (mg/ grain) Ratio % Remarks
Beta carotene oil 10.000 0.781
Vitamin D 3Oil 0.330 0.026
Synthesising complex E oil 150.000 11.719
Calcium ascorbate 75.000 5.859
Vitamine C sodium 75.000 5.859 Cross 100 mesh sieves
Thiamine mononitrate 24.680 1.928
Riboflavin 8.000 0.625
Niacinamide 8.000 0.625
Calcium pantothenate 9.600 0.750
Puridoxine hydrochloride 9.730 0.760
Biotin 0.010 0.001
Choline bitartrate 19.440 1.519
Inositol 8.000 0.625
P-aminobenzoic acid 8.000 0.625
Folic acid 0.060 0.005
Cyanocobalamin 0.030 0.002
Citrus bioflavonoids 60.000 4.688 85%, 100 mesh sieves are crossed
Fructus rosae extract 20.000 1.563
Acerola concentrate extract 20.000 1.563
Officinale root extract 20.000 1.563 Cross 100 mesh sieves
Inulin 40.000 3.125 Cross 100 mesh sieves
Rutin 20.000 1.563 Cross 100 mesh sieves
Calcium carbonate 166.250 12.988 Cross 100 mesh sieves
Magnesium carbonate 38.400 3.000 Cross 100 mesh sieves
Ferrous fumarate 17.500 1.367
Zinc oxide 6.250 0.488
Microelement pre-mix material 18.000 1.406
Phosphatide 25.600 2.000
Beeswax 12.800 1.000
Soybean oil 409.320 31.978
Add up to 1280.000 100.000

Claims (10)

1. contain a soft capsule preparation for multivitamin and plant extracts and trace element, it is characterized in that: according to weight percent meter, said preparation comprises following component:
Beta carotene oil 0.5-5.0%, vitamin C 5.0-20.0%, vitamin D oil 0.01-0.05%, vitamin E oil 5.0-10.0%, B family vitamin 5.0-15.0%, plant extracts 5.0-20.0%, calcium carbonate 10-20%, magnesium carbonate 1.0-5.5%, micro-0.5-5.0%, phosphatidase 0 .5-4.0%, beeswax 0.2-5.0%, soybean oil 30.0-50.0%.
2. a kind of soft capsule preparation containing multivitamin and plant extracts and trace element according to claim 1, it is characterized in that: described vitamin C is one or more the mixing in vitamine C sodium, calcium ascorbate, vitamin C potassium or vitamin C magnesium, and vitamin D oil is vitamin D 2or vitamin D 3one in oil.
3. a kind of soft capsule preparation containing multivitamin and plant extracts and trace element according to claim 1, is characterized in that: described B family vitamin is Cobastab 1, Cobastab 2, Cobastab 3, Cobastab 5, Cobastab 6, Cobastab 7, Cobastab 9, Cobastab 12, choline, one or more mixing in inositol or p-aminobenzoic acid.
4. a kind of soft capsule preparation containing multivitamin and plant extracts and trace element according to claim 1, is characterized in that: described plant extracts is one or more the mixing in citrus bioflavonoids, fructus rosae extract, acerola concentrate extract, Extraction of rutin thing, officinale root extract or inulin.
5. a kind of soft capsule preparation containing multivitamin and plant extracts and trace element according to claim 1, it is characterized in that: described trace element is the combination of microelement pre-mix material and micro-monomer, microelement pre-mix material is the compound of one or more components in copper, iodine, manganese, potassium, chromium, molybdenum or selenium and auxiliary material maltodextrin, and micro-monomer is the combination according to percentage by weight 0.2-0.75%:0.2-0.5% of ferrous fumarate and zinc oxide.
6. a kind of preparation method containing the soft capsule preparation of multivitamin and plant extracts and trace element according to claim 1, is characterized in that: this preparation method comprises the following steps:
(1) according to weight percent meter, the following component of precise:
Beta carotene oil 0.5-5.0%, vitamin C 5.0-20.0%, vitamin D oil 0.01-0.05%, vitamin E oil 5.0-10.0%, B family vitamin 5.0-15.0%, plant extracts 5.0-20.0%, calcium carbonate 10-20%, magnesium carbonate 1.0-5.5%, micro-0.5-5.0%, phosphatidase 0 .5-4.0%, beeswax 0.2-5.0%, soybean oil 30.0-50.0%, also cross 100 mesh sieves by each solid powder crushing material;
(2) in solid powder material, choose the material that consumption is minimum, make by the method for equal increments doubly loose, then add the solid powder material of all the other each formula ratios, fully mix, and cross 100 mesh sieves, obtain premix A;
(3) soybean oil of formula ratio is heated to more than 60 DEG C, add the beeswax of formula ratio and stir, after beeswax dissolves completely, stop heating and stir, cool to room temperature, then adding phosphatide, beta carotene oil, oily, the vitamin E oil of vitamin D of formula ratio, be stirred to evenly and slowly add premix A, limit edged stirs, and after material mixes completely, crosses twice colloid mill, obtain the content of soft capsule preparation, stand for standby use;
(4) according to weight percent meter, the following glue component of precise: glycerine 15-20%, purified water 32-41%, titanium dioxide 0.1-0.3%, yellow ferric oxide 0.1-0.3%, gelatin 40-50%;
Take the G & W of formula ratio, titanium dioxide, the yellow ferric oxide of formula ratio is added successively after being mixed by G & W, cross No. two to three colloid mills, mixed liquor is heated to 80 ~ 90 DEG C, the gelatin adding formula ratio is stirred to gelatin and dissolves completely and blend of colors evenly stops heating afterwards, the glue of soft capsule can be obtained, be incubated for subsequent use;
(5) glue of the content of step (3) gained and step (4) gained is suppressed capsule and pill, through cleaning, drying, sterilizing, packaging into products on soft capsule press.
7. a kind of preparation method containing the soft capsule preparation of multivitamin and plant extracts and trace element according to claim 6, is characterized in that: described glue component is: glycerine 18.10%, purified water 36.2%, titanium dioxide 0.23%, yellow ferric oxide 0.23%, gelatin 45.24%.
8. a kind of preparation method containing the soft capsule preparation of multivitamin and plant extracts and trace element according to claim 6, it is characterized in that: the pressing process of the compacting capsule and pill in described step (5) is: pellet press rotating speed 2.0 revs/min, sprinkler body temperature keeps 41-43 DEG C, rubber thickness is 0.8mm, loading amount is 1184-1376mg/ grain, inspection is checked in timing, the capsule and pill pressed is entered in sizing rotating cage, through cleaning, drying, sterilizing, packaging into products after sizing.
9. a kind of soft capsule preparation containing multivitamin and plant extracts and trace element according to claim 1, it is characterized in that: according to weight percent meter, said preparation comprises following component: beta carotene oil 0.781%, calcium ascorbate 9.666%, vitamin D 3oil 0.039%, vitamin E oil 7.813%, vitamin B complex 12.612%, plant extracts 14.063%, calcium carbonate 13.209%, magnesium carbonate 5.389%, ferrous fumarate 0.734%, zinc oxide 0.25%, microelement pre-mix material 0.977%, phosphatidase 2 .0%, beeswax 1.0% and soybean oil 31.467%.
10. a kind of soft capsule preparation containing multivitamin and plant extracts and trace element according to claim 9, it is characterized in that: according to weight parts, described vitamin B complex comprises following component: Cobastab 174.02, Cobastab 210.00, Cobastab 310.00, Cobastab 510.88, Cobastab 612.16, Cobastab 70.01, choline bitartrate 24.30, inositol 10.00, p-aminobenzoic acid 10.00, Cobastab 90.06, Cobastab 120.01.
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CN106937746A (en) * 2017-03-20 2017-07-11 桦南仙紫食品科技有限公司 Selenium adds calcium soft capsule and preparation method
CN107279976A (en) * 2017-07-01 2017-10-24 山东健康源生物工程有限公司 A kind of natural VE adds bata-carotene soft capsule and preparation method thereof
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CN108065403A (en) * 2017-12-08 2018-05-25 芜湖市诺康生物科技有限公司 A kind of calcium and magnesium adds the preparation method of dimension D soft capsules
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CN109480093A (en) * 2018-11-23 2019-03-19 衡阳德邦新金生物科技有限公司 A kind of organic trace element additive, feed and preparation method thereof

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CN1449746A (en) * 2003-05-07 2003-10-22 蒋家驹 Soft capsule containing trace element
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Cited By (7)

* Cited by examiner, † Cited by third party
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CN106852412A (en) * 2016-10-16 2017-06-16 长沙协浩吉生物工程有限公司 A kind of compound method of nonreactive selenium-rich laying hen nutrient solution
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CN107279976A (en) * 2017-07-01 2017-10-24 山东健康源生物工程有限公司 A kind of natural VE adds bata-carotene soft capsule and preparation method thereof
CN107969704A (en) * 2017-12-07 2018-05-01 山东禹王制药有限公司 A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof
CN108065403A (en) * 2017-12-08 2018-05-25 芜湖市诺康生物科技有限公司 A kind of calcium and magnesium adds the preparation method of dimension D soft capsules
CN109480093A (en) * 2018-11-23 2019-03-19 衡阳德邦新金生物科技有限公司 A kind of organic trace element additive, feed and preparation method thereof
CN109464418A (en) * 2018-12-26 2019-03-15 广东润源中天生物科技有限公司 A kind of vitamin C-vitamin E soft capsule and preparation method thereof

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Denomination of invention: Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation

Effective date of registration: 20191230

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