CN108065403A - A kind of calcium and magnesium adds the preparation method of dimension D soft capsules - Google Patents
A kind of calcium and magnesium adds the preparation method of dimension D soft capsules Download PDFInfo
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- CN108065403A CN108065403A CN201711297678.0A CN201711297678A CN108065403A CN 108065403 A CN108065403 A CN 108065403A CN 201711297678 A CN201711297678 A CN 201711297678A CN 108065403 A CN108065403 A CN 108065403A
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- calcium
- magnesium
- weight
- dimension
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 239000011575 calcium Substances 0.000 title claims abstract description 44
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 44
- 239000007901 soft capsule Substances 0.000 title claims abstract description 40
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 239000011777 magnesium Substances 0.000 title claims abstract description 31
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 10
- 239000002775 capsule Substances 0.000 claims abstract description 10
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims abstract description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011782 vitamin Substances 0.000 claims abstract description 8
- 108010010803 Gelatin Proteins 0.000 claims abstract description 7
- 235000013871 bee wax Nutrition 0.000 claims abstract description 7
- 239000012166 beeswax Substances 0.000 claims abstract description 7
- 229920000159 gelatin Polymers 0.000 claims abstract description 7
- 239000008273 gelatin Substances 0.000 claims abstract description 7
- 235000019322 gelatine Nutrition 0.000 claims abstract description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 7
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims abstract description 7
- 239000001095 magnesium carbonate Substances 0.000 claims abstract description 7
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims abstract description 5
- 239000001335 perilla frutescens leaf extract Substances 0.000 claims abstract description 4
- 239000008213 purified water Substances 0.000 claims abstract description 4
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000001055 magnesium Nutrition 0.000 claims description 30
- 239000003292 glue Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 22
- 238000012856 packing Methods 0.000 claims description 14
- 239000011812 mixed powder Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 10
- 238000003860 storage Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 7
- 238000004513 sizing Methods 0.000 claims description 7
- 238000007689 inspection Methods 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000001993 wax Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 239000012768 molten material Substances 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 238000010923 batch production Methods 0.000 claims description 3
- XNEYCQMMVLAXTN-UHFFFAOYSA-N carbonic acid;magnesium Chemical compound [Mg].OC(O)=O XNEYCQMMVLAXTN-UHFFFAOYSA-N 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 238000012552 review Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000012795 verification Methods 0.000 claims description 3
- 239000005022 packaging material Substances 0.000 claims description 2
- 230000007306 turnover Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 11
- 238000004140 cleaning Methods 0.000 abstract description 3
- 230000000368 destabilizing effect Effects 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 238000003304 gavage Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 206010006956 Calcium deficiency Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000008279 sol Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 229910001425 magnesium ion Inorganic materials 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 239000011746 zinc citrate Substances 0.000 description 2
- 229940068475 zinc citrate Drugs 0.000 description 2
- 235000006076 zinc citrate Nutrition 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010011469 Crying Diseases 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000035211 Heart Murmurs Diseases 0.000 description 1
- 208000008167 Magnesium Deficiency Diseases 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000000224 Night Terrors Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010041010 Sleep terror Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000018678 bone mineralization Effects 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- ZFXVRMSLJDYJCH-UHFFFAOYSA-N calcium magnesium Chemical compound [Mg].[Ca] ZFXVRMSLJDYJCH-UHFFFAOYSA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 235000004764 magnesium deficiency Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 210000005009 osteogenic cell Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses the formulas that a kind of calcium and magnesium adds dimension D soft capsules, are related to medicines and health protection food technology field, containing following component：400 450 parts by weight of calcium carbonate, 250 350 parts by weight of magnesium carbonate, 0.5 1 parts by weight of vitamine D3,350 400 parts by weight of Purple Perilla Seed Oil, 60 80 parts by weight of beeswax, 150 200 parts by weight of gelatin, 50 100 parts by weight of glycerine, 150 250 parts by weight of purified water, 0.11 0.22 parts by weight of titanium dioxide.In addition, add the preparation method of the formula of dimension D soft capsules the invention also discloses the calcium and magnesium.Calcium carbonate, magnesium carbonate, vitamine D3 play the role of collaboration enhancement in the present invention, it being capable of promoting bone growing and osteanagenesis, and whole collinear processing, nutrition leak caused by avoiding destabilizing factor, entire preparation process completes in certain clean area, it ensure that the cleaning of working environment, reduce influence of the environment to capsule to the greatest extent.
Description
Technical field
The present invention relates to medicines and health protection food technology fields, and in particular to a kind of calcium and magnesium adds the preparation method of dimension D soft capsules.
Background technology
Magnesium is one of indispensable mineral matter element of human body.Magnesium almost participates in all metabolic processes of human body,
Its intracellular content is only second to potassium.Magnesium influences potassium, sodium, " passage " of the movement of calcium ion intraor extracellular, and has maintenance biomembrane
The effect of current potential.The shortage of magnesium elements will necessarily damage to health.Magnesium deficiency neural reflex is hyperfunction or fails, muscle
Pine top；Brothers' cramp heart murmur, tachycardia；Mood is uneasy, passionnate.Magnesium is the indispensable minerals member of human body
One of element.Human body calcium deficiency can reduce the elasticity and toughness of soft tissue.Skin, which lacks elasticity, to seem slack and undisciplined, aging；Eye lens lack
Elastic, easy myopia, presbyopic；Blood vessel lacks elastic easily hardening.Calcium is a kind of natural sedative.Human body calcium deficiency can reduce nerve cell
Excitability, can cause nervous migraine (10-20% for accounting for women), dysphoria, insomnia.Baby can be caused sleep terror fright at night,
The morbid night crying of babies, night sweat, calcium deficiency can also induce the hyperactivity of children.
Chinese Patent Application No. 201710826250.4 discloses a kind of calcium tablet, the calcium tablet by weight, including such as
Lower component：Biological calcium carbonate, white granulated sugar, citric acid, xylitol, sorbierite, natural pigment, flavouring agent, borneol, vegetable fat powder, doctor
Use starch.It the advantage is that：The invention uses common BIOLOGICAL CALCIUM, cheap, reduces the making finished product of calcium tablet, and natural
It is calcareous to be easily absorbed by the body, improve juvenile and children growth and development, improve the calcium content of bone of patients with osteoporosis, and adopt
Reduce harm of the chemical pigment to body with natural pigment, it is suitable for people of all ages.But complicated component, it is possible to it can influence each other,
Make effect not notable.
Chinese Patent Application No. 201510776000.5 discloses a kind of readily absorbable calcium magnesium sheet, which is characterized in that by following
The raw material composition of parts by weight：30-60 parts of calcium carbonate, 10-20 parts of chrysanthemum extract, 10-20 parts of zinc citrate, Dicalcium Phosphate 2-
5 parts, 2-8 parts of maltodextrin, 3-8 parts of glycerine, 5-10 parts of cornstarch, 2-4 parts of sucrose.The advantages of invention is：Contain plant
Extract, zinc citrate strengthen the absorption of calcium, will not cause the deposition of calcium.Equally exist drawbacks described above.
The content of the invention
It is an object of the invention to provide the preparation method that a kind of calcium and magnesium adds dimension D soft capsules, to solve to lead in the prior art
The drawbacks described above of cause.
The present invention is achieved through the following technical solutions, and a kind of calcium and magnesium adds the formula of dimension D soft capsules, by weight, bag
It includes：
Preferably, a kind of calcium and magnesium adds the formula of dimension D soft capsules, by weight, including：
A kind of calcium and magnesium adds the preparation method of dimension D soft capsules, includes the following steps：
(1) dispensing
A, prepare before production：By between standard inspection operation of clearing out a gathering place, can be produced after qualified；
B, neck material：By batch production ordering and《Workshop neck material issuing SOP》Get raw and auxiliary material and lot number needed for this batch of output
It marks, for use；
C, dispensing：Calcium carbonate, magnesium carbonate be crushed into 100-200 mesh sieves respectively, supplementary material is weighed respectively by the prescription that feeds intake,
One person amount during weighing, people review；
D, mix：Vitamine D3 and carbonic acid magnesium powder equal increments clouding are closed, is uniformly mixed, mixed powder 1 is obtained, by carbon
Sour calcium fine powder mixes 20-30 minutes with mixed powder 1, obtains mixed powder 2, after weighing, is put into material and keeps in and put respectively, and carry out mark
Note, indicates the name of an article, lot number, quantity；
(2) molten material, colloidal sol
A, the preparation of content：Purple Perilla Seed Oil and beeswax are heated to 80-100 DEG C, beeswax is made to be cooled to 30-35 after melting
DEG C, obtain oily wax liquor；Mixed powder 2 is ground 3 times with oily wax liquor colloid mill to be made to be uniformly mixed, and treats that pelleting is used；And mark, it marks
The bright name of an article, lot number, quantity, operator；
B, the preparation of glue：Gelatin is added in when glycerine, purified water pouring into glue tank are heated to 50-60 DEG C, does not stop to stir
It mixes and is heated to 70-90 DEG C, when the time is 2-3 small, gelatin is made to be completely dissolved addition titanium dioxide and is stirred evenly, is vacuumized, deaeration,
With 100 mesh screens, filtered glue is pushed between insulation barrel storage, with 50-60 DEG C of heat preservation, treats that pelleting is used.And mark,
Indicate the name of an article, lot number, quantity, operator；
(3) pelleting
A, pelleting preparation is carried out, gets out corresponding mold, glue used and content are got from insulation barrel storage chamber
The name of an article of object material, verification glue and content material, specification, lot number, quantity；
B, check whether workshop moisture temperature meets the requirements, check whether pelleting room status indicator is correct, whether in be generated
Occurrence state；
C, pellet press is first debugged, then content feed liquid and glue are put in soft capsule pellet press and are pressed into 1.15-2.15g/
The soft capsule of grain；
E, the control of soft capsule content uniformity is within ± 5%, and every detection in 60 minutes once, rubber thickness control exists
0.80mm, left-right deviation must not exceed 0.02mm, and glue holding temperature controls 50-60 DEG C；
(4) shape
The capsule and pill pressed have to pass through rotating cage carry out 4 it is small when sizing, 18-22 DEG C of temperature, relative humidity 40%；
(5) it is dry
A, after capsule and pill sizing, divide into canopy silk vehicle, often disk dress about 2kg, is sent into hothouse and is dried, and drying is should be per small
When stir once；
B, drying parameter：Drying temperature should be controlled at 25 DEG C, and relative humidity 40%, when time 18-24 is small, rubber moisture should
Control is in 12%-16%；
(6) select ball, wash ball：It is exactly to reject underproof product to select ball, and washes the greasy dirt that ball washes away soft capsule surface；
(7) packaging, quality inspection, storage.
Preferably, -0.08MPa-0.06MPa is vacuumized in the step (2).
Preferably, workshop moisture temperature described in the step (3) is respectively 18 DEG C -22 DEG C, and 40%.
Preferably, step (7) packaging is divided into inner packing and outer packing.
Preferably, the inner packing material therefor packing timber for meeting the medicinal polyester bottles of YBB00262002 oral administration solids
Material bottling；The outer packing packed in cases for meeting GB/T6543 single and double corrugated boxes for transport packages.
Using above technical scheme, compared with prior art, the present invention has the following advantages：
1st, calcium is a kind of important element in organism.The in vivo calcium of animal not only participates in the composition of bone and tooth,
And participate in metabolism.Maintain strong bone and healthy tooth；Maintain the rhythm of the heart of rule；Relieving insomnia symptom；It helps
The metabolism of internal iron；Strengthen nervous system, particularly its reception and registration function stimulated.
2nd, magnesium ion is a kind of cation that content is more in living organism, amount be only second in entirety calcium, sodium, potassium and
Occupy the 4th；The content of magnesium ion in the cell is then only second to potassium ion and occupies second.Promote the formation of bone.In bone only
It is osteocyte 26S Proteasome Structure and Function necessary element inferior to calcium, phosphorus, to promoting bone growing and osteanagenesis, maintains bone and tooth
Intensity and density play an important roll；Magnesium is also important neurotransmitter, it can allow loosening all muscles to get off；With calcic
Food supplements together, can promote the absorption of calcium.
3rd, vitamine D3 improves absorption of the human body to calcium, phosphorus, and plasma calcium and the level of blood plasma phosphorus is made to reach degree of saturation.Promote
Into growth and bone calcification, tooth is promoted to perfect.
4th, in conclusion calcium carbonate, magnesium carbonate, vitamine D3 play the role of collaboration enhancement in the present invention, bone can be promoted
Formation and osteanagenesis, and in the preparation process in accordance with the present invention, pass through dispensing, molten material, colloidal sol, pelleting, sizing, drying and bag
Techniques such as dress, detection, storage etc. are made, and in pelleting technique, soft capsule content uniformity is controlled within ± 5%, every 60 points
Clock detects once, and for rubber thickness control in 0.80mm, left-right deviation must not exceed 0.02mm, glue holding temperature control 50-60
DEG C, this technique can effectively prevent the disintegration of capsule.And whole collinear processing, avoids nutrition caused by destabilizing factor
It is lost in, entire preparation process completes in certain clean area, ensure that the cleaning of working environment, reduce environment to the greatest extent
Influence to capsule.
Specific embodiment
Technical means, creative features, achievable purpose and effectiveness to make the present invention are easy to understand, with reference to specific
Embodiment, the present invention is further explained.
Embodiment 1
A kind of calcium and magnesium adds the formula of dimension D soft capsules, by weight：
Embodiment 2
A kind of calcium and magnesium adds the formula of dimension D soft capsules, by weight：
Embodiment 3
A kind of calcium and magnesium adds the formula of dimension D soft capsules, by weight：
Embodiment 4
A kind of calcium and magnesium adds the formula of dimension D soft capsules, by weight：
Embodiment 5
A kind of calcium and magnesium adds the formula of dimension D soft capsules, by weight：
It is worth noting that, in embodiment 1-5, making calcium and magnesium described above adds the preparation method of dimension D soft capsules, bag
Include following steps：
(1) dispensing
A, prepare before production：By between standard inspection operation of clearing out a gathering place, can be produced after qualified；
B, neck material：By batch production ordering and《Workshop neck material issuing SOP》Get raw and auxiliary material and lot number needed for this batch of output
It marks, for use；
C, dispensing：Calcium carbonate, magnesium carbonate be crushed into 200 mesh sieves respectively, supplementary material is weighed respectively by the prescription that feeds intake, and is weighed
When one person amount, a people review；
D, mix：Vitamine D3 and carbonic acid magnesium powder equal increments clouding are closed, is uniformly mixed, mixed powder 1 is obtained, by carbon
Sour calcium fine powder mixes 25 minutes with mixed powder 1, obtains mixed powder 2, after weighing, is put into material and keeps in and put respectively, and marks,
Indicate the name of an article, lot number, quantity；
(2) molten material, colloidal sol
A, the preparation of content：Purple Perilla Seed Oil and beeswax are heated to 80 DEG C, beeswax is made to be cooled to 30-35 DEG C after melting,
Obtain oily wax liquor；Mixed powder 2 is ground 3 times with oily wax liquor colloid mill to be made to be uniformly mixed, and treats that pelleting is used；And mark, it indicates
The name of an article, lot number, quantity, operator；
B, the preparation of glue：Gelatin is added in when glycerine, purified water pouring into glue tank are heated to 55 DEG C, and keeps stirring and adds
Heat to 80 DEG C, the time who 3 it is small when, be completely dissolved gelatin and add in titanium dioxide and stir evenly, vacuumize, deaeration, with 100 mesh
Filter is sieved through, filtered glue is pushed between insulation barrel storage, with 55 DEG C of heat preservations, treats that pelleting is used.And mark, indicate the name of an article,
Lot number, quantity, operator；
(3) pelleting
A, pelleting preparation is carried out, gets out corresponding mold, glue used and content are got from insulation barrel storage chamber
The name of an article of object material, verification glue and content material, specification, lot number, quantity；
B, check whether workshop moisture temperature meets the requirements, check whether pelleting room status indicator is correct, whether in be generated
Occurrence state；
C, pellet press is first debugged, then content feed liquid and glue are put in soft capsule pellet press and are pressed into 1.15-2.15g/
The soft capsule of grain；
E, the control of soft capsule content uniformity is within ± 5%, and every detection in 60 minutes once, rubber thickness control exists
0.80mm, left-right deviation must not exceed 0.02mm, and glue holding temperature controls 55 DEG C；
(4) shape
The capsule and pill pressed have to pass through rotating cage carry out 4 it is small when sizing, 20 DEG C of temperature, relative humidity 40%；
(5) it is dry
A, after capsule and pill sizing, divide into canopy silk vehicle, often disk dress about 2kg, is sent into hothouse and is dried, and drying is should be per small
When stir once；
B, drying parameter：Drying temperature should be controlled at 25 DEG C, and relative humidity 40%, when the time 20 is small, rubber moisture should be controlled
System is 14%；
(6) select ball, wash ball：It is exactly to reject underproof product to select ball, and washes the greasy dirt that ball washes away soft capsule surface；
(7) packaging, quality inspection, storage.
In addition, vacuumize 0.06MPa in the step (2).Workshop moisture temperature is respectively 122 described in the step (3)
DEG C, 40%.Step (7) packaging is divided into inner packing and outer packing.The inner packing material therefor is with meeting YBB00262002
The packaging material bottling of the medicinal polyester bottles of oral administration solid；The outer packing is with meeting the single corrugated case of GB/T6543 transportation and packing
With the packed in cases of double corrugated cases.
Acute toxicity test in mice：
Using maximum tolerated dose method, the Kunming mouse 20 that weight is 18-22g, half male and half female are selected.Take the present invention
Calcium and magnesium adds dimension D soft capsule contents 50g to add 1% sodium carboxymethylcellulose to 100mL.To being passed through when interval 4 is small in mouse one day
Mouth gavage 2 times, each gavage volume are 0.2mL/10g.bw, intergal dose 20.00g/kg.bw.Fasting 16 before gavage for the first time
Hour, it is observed continuously two weeks after gavage, records poisoning manifestations and death condition.Experimental result is as follows：
| Gender | Number of animals (only) | Approach | Dosage (g/kg.bw) | Death toll (only) | MTD(g/kg.bw) |
| It is female | 10 | Orally | 20 | 0 | >20.00 |
| It is male | 10 | Orally | 20 | 0 | >20.00 |
Kunming of the dimension D soft capsule contents to two kinds of genders is added with the calcium and magnesium of the inventive samples of 20.00g/kg.bw dosage
Apparent poisoning symptom is had no after kind intragastric administration on mice, observes 14 days without death.Animal subject execution is carried out solution dissect by the observation end of term
It looks into, the main organs such as liver,spleen,kidney, stomach, intestines, the heart, lung show no obvious abnormalities change.Illustrate that calcium and magnesium of the present invention adds dimension D soft capsules
20.00g/kg.bw is more than to Kunming mouse male and female mouse maximal tolerance dose, belongs to nontoxic grade.
Calcium and magnesium adds dimension D soft capsules to promote union experimental study
120 Kunming mouses are randomly divided into 6 groups, be respectively blank control group (gavage 10mL/kg.d physiological saline),
Dimension D soft capsule contents 50g is added to add 1% sodium carboxymethylcellulose to 100mL (gavage 10mL/kg embodiment 1-5 calcium and magnesiums
D physiological saline), every group 20, for gavage after 15 days, animal fracture model is made in every mouse right hind femur fixed point, and continues
Gavage 21 days, mouse weight of every 3 days records, each group kills 5 experiment mices at random within postoperative 7,14,21 days, removes right side
10% formaldehyde of femur is fixed, and is mixed decalcifying Fluid decalcification, is dehydrated step by step, paraffin embedding.7,14,21 days bones after fracturing are calculated respectively
The bulk density (V v t) of Osteogenic Cells, osteoblast, average external volume (V v), number density (N V) in scab.Experimental result
It is as follows：
Seven days experimental results
| Project | Control group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Vvt/% | 0.6 | 0.65 | 0.62 | 0.61 | 0.64 | 0.63 |
| Nv (a/mm3) | 2456 | 42185 | 41256 | 41362 | 42060 | 42006 |
| Vv/(μm3) | 525 | 874 | 856 | 835 | 845 | 842 |
Fortnight experimental result
| Project | Control group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Vvt/% | 0.8 | 0.88 | 0.86 | 0.84 | 0.84 | 0.88 |
| Nv (a/mm3) | 6754 | 53185 | 52985 | 52765 | 53025 | 53200 |
| Vv/(μm3) | 1087 | 1425 | 1405 | 1415 | 1421 | 1421 |
21 days experimental results
| Project | Control group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Vvt/% | 1.2 | 1.25 | 1.23 | 1.24 | 1.25 | 1.24 |
| Nv (a/mm3) | 53212 | 58963 | 58785 | 58765 | 57025 | 57985 |
| Vv/(μm3) | 1175 | 1825 | 1815 | 1795 | 1845 | 1835 |
In conclusion calcium carbonate, magnesium carbonate, vitamine D3 play the role of collaboration enhancement in the present invention, bone shape can be promoted
Into and osteanagenesis, and whole collinear processing, avoid nutrition leak caused by destabilizing factor, entire preparation process is certain
Clean area in complete, ensure that the cleaning of working environment, reduce influence of the environment to capsule to the greatest extent.
As known by the technical knowledge, the present invention can pass through the embodiment party of other essence without departing from its spirit or essential feature
Case is realized.Therefore, embodiment disclosed above, all things considered are all merely illustrative, not the only.Institute
Have within the scope of the present invention or be included in the invention in the change being equal in the scope of the present invention.
Claims (7)
1. a kind of calcium and magnesium adds the formula of dimension D soft capsules, which is characterized in that by weight, including：
。
2. a kind of calcium and magnesium according to claim 1 adds the formula of dimension D soft capsules, which is characterized in that by weight, bag
It includes：
。
3. add the preparation method of dimension D soft capsules according to claim 1-2 any one of them calcium and magnesiums, which is characterized in that including such as
Lower step：
(1) dispensing
A, prepare before production：By between standard inspection operation of clearing out a gathering place, can be produced after qualified；
B, neck material：By batch production ordering and《Workshop neck material issuing SOP》Raw and auxiliary material and lot number needed for this batch of output is got to carry out
Mark, for use；
C, dispensing：Calcium carbonate, magnesium carbonate be crushed into 100-200 mesh sieves respectively, supplementary material is weighed respectively by the prescription that feeds intake, and is weighed
When one person amount, a people review；
D, mix：Vitamine D3 and carbonic acid magnesium powder equal increments clouding are closed, is uniformly mixed, mixed powder 1 is obtained, by calcium carbonate
Fine powder mixes 20-30 minutes with mixed powder 1, obtains mixed powder 2, after weighing, is put into material and keeps in and put respectively, and marks,
Indicate the name of an article, lot number, quantity；
(2) molten material, colloidal sol
A, the preparation of content：Purple Perilla Seed Oil and beeswax are heated to 80-100 DEG C, beeswax is made to be cooled to 30-35 DEG C after melting,
Obtain oily wax liquor；Mixed powder 2 is ground 3 times with oily wax liquor colloid mill to be made to be uniformly mixed, and treats that pelleting is used；And mark, it indicates
The name of an article, lot number, quantity, operator；
B, the preparation of glue：Gelatin is added in when glycerine, purified water pouring into glue tank are heated to 50-60 DEG C, and keeps stirring and adds
Heat is to 70-90 DEG C, when the time is 2-3 small, gelatin is made to be completely dissolved addition titanium dioxide and is stirred evenly, vacuumizes, deaeration, uses
100 mesh screens, filtered glue are pushed between insulation barrel storage, with 50-60 DEG C of heat preservation, treat that pelleting is used.And mark, it marks
The bright name of an article, lot number, quantity, operator；
(3) pelleting
A, pelleting preparation is carried out, gets out corresponding mold, glue and content object used are got from insulation barrel storage chamber
The name of an article of material, verification glue and content material, specification, lot number, quantity；
B, check whether workshop moisture temperature meets the requirements, check whether pelleting room status indicator is correct, whether be in occurrence to be generated
State；
C, pellet press is first debugged, then content feed liquid and glue is put, 1.15-2.15g/ is pressed into soft capsule pellet press
Soft capsule；
E, the control of soft capsule content uniformity is within ± 5%, every detection in 60 minutes once, rubber thickness control in 0.80mm,
Left-right deviation must not exceed 0.02mm, and glue holding temperature controls 50-60 DEG C；
(4) shape
The capsule and pill pressed have to pass through rotating cage carry out 4 it is small when sizing, 18-22 DEG C of temperature, relative humidity 40%；
(5) it is dry
A, after capsule and pill sizing, divide into canopy silk vehicle, often disk dress about 2kg, is sent into hothouse and is dried, drying is to turn over per hour
It moves once；
B, drying parameter：Drying temperature should be controlled at 25 DEG C, and relative humidity 40%, when time 18-24 is small, rubber moisture should control
In 12%-16%；
(6) select ball, wash ball：It is exactly to reject underproof product to select ball, and washes the greasy dirt that ball washes away soft capsule surface；
(7) packaging, quality inspection, storage.
4. a kind of calcium and magnesium according to claim 3 adds the preparation method of dimension D soft capsules, it is characterised in that：The step (2)
In vacuumize -0.08MPa-0.06MPa.
5. a kind of calcium and magnesium according to claim 3 adds the preparation method of dimension D soft capsules, it is characterised in that：The step (3)
Described in workshop moisture temperature be respectively 18 DEG C -22 DEG C, 40%.
6. a kind of calcium and magnesium according to claim 3 adds the preparation method of dimension D soft capsules, it is characterised in that：The step (7)
Packaging is divided into inner packing and outer packing.
7. a kind of calcium and magnesium according to claim 6 adds the preparation method of dimension D soft capsules, it is characterised in that：The inner packing
Material therefor is bottled with the packaging material for meeting the medicinal polyester bottles of YBB00262002 oral administration solids；The outer packing is with meeting GB/
The packed in cases of T6543 single and double corrugated boxes for transport packages.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697802A (en) * | 2012-06-29 | 2012-10-03 | 广东仙乐制药有限公司 | Composite calcium preparation and preparation method thereof |
| CN105077268A (en) * | 2015-07-10 | 2015-11-25 | 江苏艾兰得营养品有限公司 | Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation |
| CN106619705A (en) * | 2016-12-02 | 2017-05-10 | 芜湖市诺康生物科技有限公司 | Soft capsules containing calcium, magnesium and vitamin D and preparation method of soft capsules |
-
2017
- 2017-12-08 CN CN201711297678.0A patent/CN108065403A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697802A (en) * | 2012-06-29 | 2012-10-03 | 广东仙乐制药有限公司 | Composite calcium preparation and preparation method thereof |
| CN105077268A (en) * | 2015-07-10 | 2015-11-25 | 江苏艾兰得营养品有限公司 | Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation |
| CN106619705A (en) * | 2016-12-02 | 2017-05-10 | 芜湖市诺康生物科技有限公司 | Soft capsules containing calcium, magnesium and vitamin D and preparation method of soft capsules |
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