CN107969704A - A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof - Google Patents
A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof Download PDFInfo
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- CN107969704A CN107969704A CN201711289116.1A CN201711289116A CN107969704A CN 107969704 A CN107969704 A CN 107969704A CN 201711289116 A CN201711289116 A CN 201711289116A CN 107969704 A CN107969704 A CN 107969704A
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- China
- Prior art keywords
- vitamin
- premix
- preparation
- soft capsule
- vitamin premix
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 235000019742 Vitamins premix Nutrition 0.000 title claims abstract description 38
- 239000007901 soft capsule Substances 0.000 title claims abstract description 35
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 28
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 26
- 239000000203 mixture Substances 0.000 claims abstract description 25
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 15
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960000304 folic acid Drugs 0.000 claims abstract description 14
- 239000011724 folic acid Substances 0.000 claims abstract description 14
- 235000019152 folic acid Nutrition 0.000 claims abstract description 14
- 239000011122 softwood Substances 0.000 claims abstract description 14
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 13
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 13
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 13
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 13
- 239000011715 vitamin B12 Substances 0.000 claims abstract description 13
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 13
- 239000011718 vitamin C Substances 0.000 claims abstract description 13
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 12
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims abstract description 12
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 12
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 12
- 239000011570 nicotinamide Substances 0.000 claims abstract description 12
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 12
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 12
- 229960002079 calcium pantothenate Drugs 0.000 claims abstract description 11
- 239000011691 vitamin B1 Substances 0.000 claims abstract description 11
- 235000020958 biotin Nutrition 0.000 claims abstract description 10
- 239000011616 biotin Substances 0.000 claims abstract description 10
- 229960002685 biotin Drugs 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 8
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000007873 sieving Methods 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 7
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 6
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000009835 boiling Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000001694 spray drying Methods 0.000 abstract description 3
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract description 2
- 238000012546 transfer Methods 0.000 abstract description 2
- 229940088594 vitamin Drugs 0.000 description 8
- 229930003231 vitamin Natural products 0.000 description 8
- 235000013343 vitamin Nutrition 0.000 description 8
- 239000011782 vitamin Substances 0.000 description 8
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000003305 oil spill Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- WVAKRQOMAINQPU-UHFFFAOYSA-N 2-[4-[2-[5-(2,2-dimethylbutyl)-1h-imidazol-2-yl]ethyl]phenyl]pyridine Chemical compound N1C(CC(C)(C)CC)=CN=C1CCC1=CC=C(C=2N=CC=CC=2)C=C1 WVAKRQOMAINQPU-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- -1 biology Element Chemical compound 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/22—Agglomeration or granulation with pulverisation of solid particles, e.g. in a free-falling curtain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of vitamin premix of suitable soft capsule and preparation method thereof.The raw material composition is as follows：Vitamin B1, vitamin B2, vitamin C, niacinamide, vitamin B6, calcium pantothenate, vitamin B12, biotin, folic acid, maltodextrin.Softwood is first made in raw material, through fineness made from drying, crushing, sieving >=100 uniform fine powders of purpose；The present invention uses material by wet type mixing softwood technique first, the composition transfer caused by common spray drying high temperature, obtained vitamin premix grain fineness in prepared by premix is avoided to be uniformly distributed up to 200 mesh, material, be not in classification phenomenon during production and transport, stability is good.
Description
Technical field
The present invention relates to a kind of vitamin premix of suitable soft capsule preparation and preparation method thereof, belong to vitamin
Preparation technique field.
Background technology
Vitamin is a kind of trace organic substance that maintains people's normal physiological function and must be obtained from food, in human body
Play an important role in growth, metabolism, growth course.This kind of material is not the raw material for forming bodily tissue, nor energy
The source of amount, but a kind of Auto-regulator, play an important role in metabolism.With the quickening pace of modern life, only
By food supplement it is difficult to ensure that human body is to the demand of vitamin, multidimensional soft capsule is that one kind can supplement various vitamins at the same time
Preparation, mainly using soybean oil, beeswax as auxiliary material, but be easy to cause product oil leak, its reason is mainly content with solid content
Based on, for solia particle in rubber commissure, particulate is excessive just to occur oil leakage phenomenon；Vitamin adds in soft capsule preparation at the same time
Dosage is all micro, it is difficult to ensure that mixture homogeneity and because of the too big easy oil leak of soft capsule preparation of granularity.When addition trace content
During material, simple stirring is it is difficult to ensure that micro active ingredient is uniformly mixed.Premix is because its grain fineness, component degree of scatter
Advantage, use is extensive in soft capsule preparation, at present the preparation method of vitamin premix be after feed product is crushed with
The effect of carriers such as maltodextrin directly mix, and additive amount is rare component uses plus the spray drying of maltodextrin carrier.This side
There are problems with for method：(1) it is spray-dried excessive temperature and easily causes component damages；(2) mixture homogeneity is undesirable, even if
It also is difficult to ensure that the mixture homogeneity coefficient of variation is less than 5% using advanced mixing apparatus；(3) vitamin premix of production exists
The classification phenomenon according to the ascending arrangement of density often occurs because the density of each component is different in transportational process.
The content of the invention
In order to overcome problem present in existing premix production, it is pre- that the present invention provides a kind of vitamin of suitable soft capsule
Batch mixing and preparation method thereof, gained vitamin premix grain fineness is up to standard, the material uniformity coefficient of variation is less than 5%, production
Do not have to be classified phenomenon in transportational process.
Term explanation：
Equal increments method：When raw material components have a variety of and dosage it is different when, take minimum component and equivalent time
A small amount of components, is uniformly mixed, adds the remainder of the secondary minor component of same mixture equivalent or/and the group that other amounts are big
Divide and be uniformly mixed, so a times amount is increased up untill adding the maximum amount of component.
Fineness：Refer to the degree of grinding of solid material, the general screen number with sieving represents that screen number is bigger, thing
Expect that fineness is thinner, particle is with regard to smaller.
To achieve the above object, the present invention is achieved by the following technical programs：
A kind of vitamin premix of suitable soft capsule, is that following raw material is first made softwood, through drying, crushing, sieving
The uniform fine powder of purpose of obtained fineness >=100；The raw material weight is as follows than forming：
Vitamin B10.2%~0.9%, vitamin B20.2%~1.0%, vitamin C 10%~80%, niacinamide
5%~8%, vitamin B60.5%~2.5%, calcium pantothenate 1%~3%, vitamin B120.0012%~0.0035%, it is raw
Thing element 0.1%~0.5%, folic acid 0.05%~0.5%, maltodextrin 10%~30%.
Preferable according to the present invention, the raw material weight is as follows than forming：
Vitamin B10.2%~0.4%, vitamin B20.2%~0.4%, vitamin C 30%~50%, niacinamide
5%~8%, vitamin B60.3%~0.5%, calcium pantothenate 2%~5%, vitamin B120.001%~0.002%, it is biological
Element 0.01%~0.03%, folic acid 0.0533%~0.086%, maltodextrin 10%~30%.
It is further preferred that the raw material weight is as follows than forming：
Vitamin B10.25%th, vitamin B20.33%th, vitamin C 40%, niacinamide 1.667%, vitamin B6
0.375%th, calcium pantothenate 1.35%, vitamin B120.001%th, biotin 0.0158%, folic acid 0.0833%, maltodextrin
55%.
It is further preferred that the fineness of said vitamin premix is 100-200 mesh.
To meet to be used to prepare the needs of soft capsule, make the mesh of multivitamin premix grain fineness >=100, trace material
The uniformity coefficient of variation is less than 5%, and the present invention provides following specific preparation method：
A kind of preparation method of vitamin premix, including step：
(1) proportioning is pressed by vitamin B1, vitamin B2, vitamin C, niacinamide, vitamin B6, calcium pantothenate, biotin, leaf
Acid is uniformly mixed by equal increments method, then is together added in high speed wet-mixing machine with maltodextrin, is mixed 2~5 minutes, is obtained
Mixture；
(2) by vitamin B12It is dissolved in 40%~90% ethanol solution, adds the high speed wet-mixing machine of step (1)
It is interior, mixed at high speed 1~3 minute；Softwood is made；
(3) by the drying of obtained softwood, crushing, sieving.
It is preferable according to the present invention, in the step (2), the vitamin B12With the mass volume ratio of the ethanol solution
For 0.1~0.5g/100mL.
Preferable according to the present invention, the rotating speed of the high speed wet-mixing machine of the step (2) is 1500-2800r/min.
Preferable according to the present invention, the drying described in step (3) is：It is dry that softwood made from step (2) is placed in boiling
It is dry to moisture 2%~7% in dry machine.It is further preferred that the inlet air temperature of boiling drier is 60 DEG C~70 DEG C.
Preferable according to the present invention, the crushing described in step (3) is：By dried material in high speed vibrator mill
It is interior to crush 2~5 minutes.
Preferable according to the present invention, the sieving described in step (3) is：Powder after crushing is crossed into the mesh of 100 mesh~200
Sieve.Gained fine powder is the vitamin premix of the suitable production soft capsule preparation of the present invention.
Beneficial effects of the present invention：
1st, the present invention presses equal increments method to vitamin B1, vitamin B2, vitamin C, niacinamide, vitamin B6, pantothenic acid
Calcium, biotin, folic acid mixing, can be to avoid the problem of each component ratio differs greatly, is not easy to mix in formula.The present invention will add
The vitamin B of dosage rareness12It is dissolved in ethanol solution, serves as adhesive, using equal increments method charging mixing, passes through wet method
Mixing softwood processed, makes material reach further mixing, solve the problems, such as it is existing in the prior art, prepare it is uniform, stablize it is suitable soft
The vitamin premix of capsule.The mixture homogeneity coefficient of variation is less than 5%.
2nd, the vitamin premix of the suitable soft capsule preparation of the present invention, by mixing, softwood processed, drying, crushing, sieving,
Trace material, which reaches, to be sufficiently mixed uniformly；Secondly, crushed by vibration, sieving, material particles fineness is avoided up to more than 100 mesh
In production process of soft capsules, oil leakage phenomenon occurs, and ensure that the quality of production of soft capsule.
3rd, the present invention 9 kinds of vitamins of collocation meticulously, largely meet Chinese human needs, effectively supplement the daily institute of human body
Need, can build up health, prevention disease.
4th, compared with traditional direct mixing method preparation process, the preparation process of vitamin premix of the present invention is simple, easily
In operation.The composition transfer caused by common spray drying high temperature is avoided, significantly improves the uniformity of vitamin premix
And the stability of various vitamins.
Brief description of the drawings
Fig. 1 is the vitamin premix preparation technology flow chart of suitable soft capsule preparation of the invention；It is 10 in dotted line in Fig. 1
Ten thousand grades of clean areas.
Embodiment
The invention will be further described with reference to the accompanying drawings and examples, but not limited to this." % " in embodiment is equal
For mass percent, except special instruction.
Embodiment 1：A kind of vitamin premix of suitable soft capsule dosage form, by vitamin B1, vitamin B2, vitamin C,
Niacinamide, vitamin B6, calcium pantothenate, vitamin B12, biotin, folic acid, maltodextrin be made, technological process is as shown in Figure 1.
Raw material composition is as follows：
Preparation process is as follows：
(1) by vitamin B in cleaning bag1, vitamin B2, vitamin C, niacinamide, vitamin B6, calcium pantothenate, biology
Element, folic acid press equal increments method, and first biotin 0.2g is mixed with equivalent folic acid (0.2g), obtains 0.4g mixtures；Add same
Folic acid (0.4g) mixing of mixture equivalent, obtains 0.8g mixtures；Add the folic acid (0.6g) and dimension with the mixture equivalent
Raw element B1(0.2g), obtains 1.6g mixtures；The rest may be inferred, until the maximum amount of vitamin C is added, mixture and maltodextrin one
Rise and be placed in mixing 3 minutes in high speed wet-mixing machine；
(2) by vitamin B12It is dissolved in the ethanol solution 70mL of mass fraction 60%, puts into the high speed in step (1)
In wet-mixing machine, 2500r/min mixed at high speed 2 minutes, is made softwood；
(3) softwood made from step (2) is put into boiling drier, 70 DEG C of temperature setting is dry to moisture 3%；Will be dry
Dry material in vibrator mill in crushing 3 minutes；Material after crushing crosses 100 mesh sieves, and gained fine powder material is to be applicable in soft capsule
The vitamin premix A of preparation.
Embodiment 2：As described in Example 1, the difference is that raw material weight composition is changed to：
The vitamin premix B for being applicable in soft capsule preparation is made according to 1 the method for embodiment.
Embodiment 3：As described in Example 1, the difference is that raw material weight composition is changed to：
The vitamin premix C for being applicable in soft capsule preparation is made according to 1 the method for embodiment.
Embodiment 4:Vitamin premix is used for the detection of soft capsule preparation oil spill rate and the evaluation of functional component mixture homogeneity
1. experiment material：Vitamin premix A 500g, beeswax 66g, soybean that are applicable in soft capsule preparation of Example 1
Oily 1034g is pressed into soft capsule, softgel shell composition as content by the prior art：Gelatin 1000g, glycerine 400g, water 900g,
Burnt sugar coloring 10g.Soft capsule specification is that specification is 1000mg contents/grain.
2. experimental method：Separately sampled 10 parts, every part of 5 soft capsules, detect various functional component contents, as follows
Calculate the coefficient of variation of every kind of component content.
Using the respective value of every kind of functional component content of each measure as X1、X2、X3、X4、X5、X6、X7、X8、X9、X10, it is flat
Average calculation method：
Its standard deviation computational methods：
By standard deviation S and average value X-Calculate coefficient of variation CV：
Table 1, testing result
By table 1 as it can be seen that the detection data coefficient of variation of each active ingredient is respectively less than national premix standard≤5%.This hair
It is bright be applicable in soft capsule preparation vitamin premix mixture homogeneity it is good.Produced for soft capsule preparation, product is oil spill rate
0%.
The vitamin premix mixture homogeneity of suitable soft capsule preparation of the invention is good, the product leakage of compacting soft capsule preparation
Oil cut rate is 0%, respectively with the vitamin premix B of the suitable soft capsule preparation of embodiment 2, the suitable soft capsule system of embodiment 3
The vitamin premix C of agent, repeats above-mentioned experiment detection functional component content, acquired results are without essential difference.
For those skilled in the art, it is various corresponding can be made according to above technical scheme and design for other
Change and deformation, and all change and deformation should all belong within the protection domain of the claims in the present invention.
Claims (10)
1. a kind of vitamin premix of suitable soft capsule, is that following raw material is first made softwood, through drying, crushing, crosses sieve series
The uniform fine powder of purpose of fineness >=100；The raw material weight is as follows than forming：
Vitamin B10.2%~0.9%, vitamin B20.2%~1.0%, vitamin C 10%~80%, niacinamide 5%~
8%th, vitamin B60.5%~2.5%, calcium pantothenate 1%~3%, vitamin B120.0012%~0.0035%, biotin
0.1%~0.5%, folic acid 0.05%~0.5%, maltodextrin 10%~30%.
2. the vitamin premix of suitable soft capsule as claimed in claim 1, it is characterised in that the raw material weight is than composition
It is as follows：
Vitamin B10.2%~0.4%, vitamin B20.2%~0.4%, vitamin C 30%~50%, niacinamide 5%~
8%th, vitamin B60.3%~0.5%, calcium pantothenate 2%~5%, vitamin B120.001%~0.002%, biotin
0.01%~0.03%, folic acid 0.0533%~0.086%, maltodextrin 10%~30%.
3. the vitamin premix of suitable soft capsule as claimed in claim 1, it is characterised in that the raw material weight is than composition
It is as follows：
Vitamin B10.25%th, vitamin B20.33%th, vitamin C 40%, niacinamide 1.667%, vitamin B6
0.375%th, calcium pantothenate 1.35%, vitamin B120.001%th, biotin 0.0158%, folic acid 0.0833%, maltodextrin
55%.
4. the vitamin premix of suitable soft capsule as claimed in claim 1, it is characterised in that the vitamin premix
Fineness is 100-200 mesh.
5. a kind of preparation method of any one of the claim 1-4 vitamin premix, including step：
(1) proportioning is pressed by vitamin B1, vitamin B2, vitamin C, niacinamide, vitamin B6, calcium pantothenate, biotin, folic acid presses
Equal increments method is uniformly mixed, then is together added in high speed wet-mixing machine with maltodextrin, is mixed 2~5 minutes, is mixed
Thing；
(2) by vitamin B12It is dissolved in 40%~90% ethanol solution, adds in the high speed wet-mixing machine of step (1),
Mixed at high speed 1~3 minute；Softwood is made；
(3) by the drying of obtained softwood, crushing, sieving.
6. the preparation method of vitamin premix as claimed in claim 5, it is characterised in that in step (2), the vitamin
B12Mass volume ratio with the ethanol solution is 0.1~0.5g/100mL.
7. the preparation method of vitamin premix as claimed in claim 5, it is characterised in that the high speed wet-mixing of step (2)
The rotating speed of machine is 1500-2800r/min.
8. the preparation method of vitamin premix as claimed in claim 5, it is characterised in that put softwood made from step (2)
In in boiling drier, dry to moisture 2%~7%.
9. the preparation method of vitamin premix as claimed in claim 7, it is characterised in that the inlet air of the boiling drier
Temperature is 60 DEG C~70 DEG C.
10. the preparation method of vitamin premix as claimed in claim 5, it is characterised in that in step (3), the powder
It is broken to be：Dried material is crushed 2~5 minutes in high speed vibrator mill；Powder after crushing is crossed into 100 mesh~200
Mesh sieve.
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| CN109512777A (en) * | 2018-12-20 | 2019-03-26 | 广州汉光药业股份有限公司 | A kind of preparation method improving Vitamin C Stability in compound drops |
| CN111374280A (en) * | 2018-12-28 | 2020-07-07 | 江苏维乐益生食品科技有限公司 | Full-vitamin carrot powder and preparation method thereof |
| CN112022832A (en) * | 2020-09-24 | 2020-12-04 | 玉溪健坤生物药业有限公司 | High-quality formula raw material of NAD respiratory chain and method for preparing soft capsule contents |
| CN113180244A (en) * | 2021-05-31 | 2021-07-30 | 临汾市力圣生物科技开发有限公司 | Folic acid drying process |
| CN114158736A (en) * | 2021-12-10 | 2022-03-11 | 青岛圣桐营养食品有限公司 | Compound vitamin suitable for full-nutrition formula food with special medical application |
| CN114617901A (en) * | 2022-03-11 | 2022-06-14 | 陕西必康制药集团控股有限公司 | Composition for preventing and treating diseases caused by B vitamins and vitamin C deficiency and preparation method thereof |
| RU2795624C1 (en) * | 2023-03-18 | 2023-05-05 | Общество с ограниченной ответственностью "ПРОМИКС" | Composition for the treatment of biotin-deficient conditions in children, as well as a method of treatment using such a composition |
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| CN114158736A (en) * | 2021-12-10 | 2022-03-11 | 青岛圣桐营养食品有限公司 | Compound vitamin suitable for full-nutrition formula food with special medical application |
| CN114617901A (en) * | 2022-03-11 | 2022-06-14 | 陕西必康制药集团控股有限公司 | Composition for preventing and treating diseases caused by B vitamins and vitamin C deficiency and preparation method thereof |
| RU2795624C1 (en) * | 2023-03-18 | 2023-05-05 | Общество с ограниченной ответственностью "ПРОМИКС" | Composition for the treatment of biotin-deficient conditions in children, as well as a method of treatment using such a composition |
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