CN105193826A - Preparation method of vitamin D3 premix and vitamin D3 premix prepared through preparation method - Google Patents
Preparation method of vitamin D3 premix and vitamin D3 premix prepared through preparation method Download PDFInfo
- Publication number
- CN105193826A CN105193826A CN201510586220.1A CN201510586220A CN105193826A CN 105193826 A CN105193826 A CN 105193826A CN 201510586220 A CN201510586220 A CN 201510586220A CN 105193826 A CN105193826 A CN 105193826A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- premix
- preparation
- prepared
- alcoholic solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a preparation method of vitamin D3 premix and the vitamin D3 premix prepared through the preparation method. The preparation method of the vitamin D3 premix includes the steps that 1, an ethanol solution of vitamin D3 is prepared; 2, weighed solid absorption materials are added to the ethanol solution, prepared in the step 1, of the vitamin D3 in the stirring process; 3, mixed materials prepared in the step 2 are subjected to vacuum drying for 0.1-5 hours under the indoor temperature condition, sieved and refined, and then the vitamin D3 premix is obtained. According to the vitamin D3 premix, the solid materials with the proportions differing greatly are evenly mixed, the vitamin D3 premix is suitable for mixing heat sensitive materials, and the content of the vitamin D3 in the prepared vitamin D3 premix is uniform and can be maintained on a stable level for a long time. The content of the vitamin D3 in the prepared premix ranges from 1.5 micrograms per g to 10 micrograms per g, the prepared vitamin D3 premix is used for preparing calcium supplementing healthcare products and drugs, and then the purpose of evenly mixing the vitamin D3 and other materials of the calcium supplementing healthcare products and drugs can be conveniently achieved.
Description
(1) technical field
The present invention relates to a kind of preparation method of vitamin D3 premix material and obtained vitamin D3 premix material thereof.
(2) background technology
Vitamin D3 is a kind of activity form that in vitamin D, biological metabolism rate is the highest, and the daily vitamin D mentioned mainly refers to vitamin D3.Research finds, vitamin D3 has promotion intestinal calcium absorption, induction sclerotin calcium phosphorus is calm and prevent rickets physiological function, in the mineralization process of skeletal tissue in vivo very important effect, be embodied in: improve human body to the absorption of calcium, phosphorus, the level of plasma calcium and blood plasma phosphorus is reached capacity degree; Growth promoting effects and skeleton calcification, promote that tooth perfects; Increased the absorption of phosphorus by intestinal wall, and increase absorbing again of phosphorus by renal tubules; Maintain the normal level of citrate in blood; Prevent aminoacid from being lost by kidney.In addition, vitamin D3 can also regulate Growth of Cells, comprises the normal differentiation of inducing cell and the transition propagation of T suppression cell, has certain help to the disease of propagation such as transition such as cell such as treatment tumor, psoriasis etc.Therefore, vitamin D3 plays a very important role maintenance the healthy of people.
The vitamin D3 7-DHC that mainly percutaneous epidermis and intradermal contain in human body changes through ultraviolet (wavelength 265 ~ 228nm) irradiation, 7-dehydrogenation gallbladder alcohol then changes generation, so there is people to be also its sun vitamin by cholesterol.If child fully can accept direct sunlight skin more than 4-6 hour, the vitamin D3 by self synthesis just can meet somatogenic need substantially.But under the impact of the problems such as air pollution, various places Changes in weather, various countries crowd accepts the time at sunshine out of doors in minimizing, causes the vitamin D3 in people's body to present the phenomenon extensively lacked.Although vitamin D3 also can obtain from animal food, and content is very low after all, so generally, it is very difficult for depending merely on and obtain enough vitamin D3 from food.
At present, the calcium supplement health care product that market is sold and medicine are all take vitamin as D3 is auxiliary, promote that human body is to the absorption of calcium, phosphorus, but the content of vitamin D3 in calcium supplement health care product and medicine is extremely low, very easily occur when mixing with other solid materials mixing uneven phenomenon, cause the content of vitamin D3 in calcium supplement health care product and medicine unstable, do not reach the health-care effect of expection.Therefore, the mixing quality of vitamin D3 and other solid materials is the key factors ensureing calcium supplement health care product and drug quality.The conventional equivalent that the method for two kinds of solid material mix homogeneously mainly contained is progressively increased method, polishing, spray drying method, micronization, fusion method.These method major parts are not all suitable for the mixing of two kinds of materials that ratio differs greatly, the i.e. mixing of the enable two kinds of materials differed greatly for ratio, also because it is high to the requirement of equipment and technology, complex process, complex operation, large-scale production bad adaptability, or be not suitable for the material of heat sensitivity, and can not apply in the preparation of vitamin D3.
Along with improving constantly of China's living standard, people have had the importance of replenishing the calcium and have more fully been familiar with, the demand of calcium supplementing product is constantly increased, in order to ensure the quality of calcium supplementing product, the present invention aims to provide and a kind ofly better can ensure the preparation method of the vitamin D3 premix material of calcium supplementing product quality and obtained vitamin D3 premix material thereof.
(3) summary of the invention
The present invention in order to make up the deficiencies in the prior art, provide that a kind of preparation method is simple, low for equipment requirements, technique and simple to operate, be suitable for large-scale production, significantly reduce production cost, obtained vitamin d3 levels evenly and stablize, the preparation method of vitamin content uniform vitamin D3 premix material in the calcium supplement health care product that uses this vitamin D3 premix material to prepare and medicine and obtained vitamin D3 premix material thereof.
The present invention is achieved through the following technical solutions:
A preparation method for vitamin D3 premix material, comprises the steps:
(1) precision takes vitamin D3 in right amount, and it be dissolved in completely in the ethanol of 80%-100% under room temperature condition, obtained concentration is the alcoholic solution of the vitamin D3 of 2.7 μ g/g-18mg/g;
(2) be the proportioning of 1:0.3-0.7 according to the alcoholic solution mass ratio of the obtained vitamin D3 of solid sorbent material and step (1), it is appropriate that precision takes solid sorbent material, and while stirring the solid sorbent material taken is added in the alcoholic solution of the obtained vitamin D3 of step (1) at ambient temperature, until the alcoholic solution of vitamin D3 absorbs by solid sorbent material completely, obtained mixed material, makes in mixed material not containing remaining alcoholic solution and dry solid sorbent material;
(3) by the mixed material vacuum drying 0.1-5 hour at ambient temperature that step (2) is obtained, then cross 20-300 mesh sieve granulate, obtain vitamin D3 premix material.
Solid sorbent material in described step (2) is sorbitol, mannitol, xylitol, chitin or Polyethylene Glycol, and the molecular weight of described Polyethylene Glycol is 6000-10000.
In obtained vitamin D3 premix material, the content of vitamin D3 is 1.5 μ g/g-10mg/g.
The preparation method of vitamin D3 premix material of the present invention and the beneficial effect of obtained vitamin D3 premix material thereof are: preparation method is simple, atomic for the content being soluble in ethanol little vitamin D3 material dosing is dissolved in after making solution in the ethanol of 80%-100%, again the solid sorbent material being insoluble to or being slightly soluble in ethanol is dropped in the alcoholic solution of this vitamin D3, the capillarity of solid sorbent material is utilized to be absorbed completely by alcoholic solution, then the mixed material obtained after having absorbed solution at normal temperatures at vacuum drying oven inner drying, sieve granulate, obtain vitamin D3 premix material.The solid material Homogeneous phase mixing that the preparation method of vitamin D3 premix material of the present invention makes ratio differ greatly, and be applicable to heat sensitive material mixing, in the vitamin D3 premix material of preparing, the content of vitamin D3 evenly and can maintain more stable level for a long time.By the vitamin D3 premix material of preparation for the preparation of calcium supplement health care product and medicine, the mixed uniformly object of unclassified stores by vitamin D3 and calcium supplement health care product and medicine conveniently can be realized.Vitamin d3 levels in calcium supplement health care product and medicine is even, ensure that people each serving vitamin D3 consumption stablize, effectively supplement the vitamin D3 of needed by human body.In vitamin D3 premix material of the present invention, the content range of vitamin D3 is at 1.5 μ g/g (6IU/g)-10mg/g (400000IU/g), may be used for preparing the different vitamin D3 premix material of content.The preparation method of vitamin D3 premix material of the present invention is low for equipment requirements, technique and simple to operate, is suitable for large-scale production, considerably reduces production cost.
(4) accompanying drawing explanation
Below in conjunction with accompanying drawing, the present invention is further illustrated.
Fig. 1 is the process chart of preparation method of the present invention.
(5) detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto, and the preparation method in embodiment is customary preparation methods, no longer describes in detail.
Embodiment 1:
As shown in Figure 1, the preparation method of this vitamin D3 premix material, adopts following steps:
(1) precision takes vitamin D3 7.5mg, and it be dissolved in completely under room temperature in the ethanol of appropriate 90%, obtained concentration is the alcoholic solution of the vitamin D3 of 2.68 μ g/g, and precision takes this solution 560 grams, for subsequent use;
(2) precision takes sorbitol 1000g, while stirring taken sorbitol is added in the alcoholic solution of 560 grams of obtained vitamin D3 of step (1) under room temperature, obtained mixed material, not containing remaining alcoholic solution and dry solid sorbent material in mixed material;
(3) mixed material that step (2) is obtained is poured out, in material disc, spread out even rear feeding vacuum drier, carry out vacuum drying at normal temperatures after 1 hour, dried mixed material is crossed 80 mesh sieve granulate, obtain vitamin D3 premix material.
In the vitamin D3 premix material that the present embodiment obtains, the content of vitamin D3 is 1.5 μ g/g.
Embodiment 2:
As shown in Figure 1, the preparation method of this vitamin D3 premix material, adopts following steps:
(1) precision takes vitamin D3 10g, and it be dissolved in completely under room temperature in the ethanol of appropriate 80%, obtained concentration is the alcoholic solution of the vitamin D3 of 17.8mg/g, and precision takes this solution 560 grams, for subsequent use;
(2) precision takes sorbitol 1000g, while stirring taken sorbitol is added in the alcoholic solution of 560 grams of obtained vitamin D3 of step (1) under room temperature, obtained mixed material, not containing remaining alcoholic solution and dry sorbitol in mixed material;
(3) mixed material that step (2) is obtained is poured out, in material disc, spread out even rear feeding vacuum drier, carry out vacuum drying at normal temperatures after 1 hour, dried mixed material is crossed 20 mesh sieve granulate, obtain vitamin D3 premix material.
In the vitamin D3 premix material that the present embodiment obtains, the content of vitamin D3 is 10mg/g.
Embodiment 3:
As shown in Figure 1, the preparation method of this vitamin D3 premix material, adopts following steps:
(1) precision takes vitamin D3 5g, and it be dissolved in completely under room temperature in the ethanol of appropriate 95%, obtained concentration is the alcoholic solution of the vitamin D3 of 8.8mg/g, and precision takes this solution 560 grams, for subsequent use;
(2) precision takes sorbitol 1000g, while stirring sorbitol is added in the alcoholic solution of 560 grams of obtained vitamin D3 of step (1) under room temperature, obtained mixed material, not containing remaining alcoholic solution and dry sorbitol in mixed material;
(3) mixed material that step (2) is obtained is poured out, in material disc, spread out even rear feeding vacuum drier, carry out vacuum drying at normal temperatures after 2 hours, dried mixed material is crossed 80 mesh sieve granulate, obtain vitamin D3 premix material.
In the vitamin D3 premix material that the present embodiment obtains, the content of vitamin D3 is 5mg/g.
Embodiment 4:
As shown in Figure 1, the preparation method of this vitamin D3 premix material, adopts following steps:
(1) be dissolved in completely by 7.5mg vitamin D3 under room temperature in the ethanol of appropriate 90%, obtained concentration is the alcoholic solution of the vitamin D3 of 2.68 μ g/g, and precision takes this solution 560 grams, for subsequent use;
(2) precision takes chitin 1000g, while stirring taken chitin is added in the alcoholic solution of 560 grams of obtained vitamin D3 of step (1) under room temperature, obtained mixed material, not containing remaining alcoholic solution and dry chitin in mixed material;
(3) mixed material that step (2) is obtained is poured out, in material disc, spread out even rear feeding vacuum drier, carry out vacuum drying at normal temperatures after 1 hour, dried mixed material is crossed 80 mesh sieve granulate, obtain vitamin D3 premix material.
In the vitamin D3 premix material that the present embodiment obtains, the content of vitamin D3 is 1.5 μ g/g.
Embodiment 5:
As shown in Figure 1, the preparation method of this vitamin D3 premix material, adopts following steps:
(1) precision takes vitamin D3 10g, and it be dissolved in completely under room temperature in the ethanol of appropriate 100%, obtained concentration is the alcoholic solution of the vitamin D3 of 17.8mg/g, and precision takes this solution 560 grams, for subsequent use;
(2) precision takes xylitol 1000g, while stirring taken xylitol is added in the alcoholic solution of 560 grams of obtained vitamin D3 of step (1) under room temperature, obtained mixed material, not containing remaining alcoholic solution and dry xylitol in mixed material;
(3) mixed material that step (2) is obtained is poured out, in material disc, spread out even rear feeding vacuum drier, carry out vacuum drying at normal temperatures after 5 hours, dried mixed material is crossed 80 mesh sieve granulate, obtain vitamin D3 premix material.
In the vitamin D3 premix material that the present embodiment obtains, the content of vitamin D3 is 10mg/g.
Embodiment 6:
As shown in Figure 1, the preparation method of this vitamin D3 premix material, adopts following steps:
(1) precision takes vitamin D3 5g, and it be dissolved in completely under room temperature in the ethanol of appropriate 90%, obtained concentration is the alcoholic solution of the vitamin D3 of 8.9mg/g, and precision takes this solution 560 grams, for subsequent use;
(2) precision takes Polyethylene Glycol (6000) 1000g, while stirring taken Polyethylene Glycol is added in the alcoholic solution of 560 grams of obtained vitamin D3 of step (1) under room temperature, obtained mixed material, not containing remaining alcoholic solution and dry Polyethylene Glycol in mixed material;
(3) mixed material that step (2) is obtained is poured out, even rear feeding vacuum drier is spread out in material disc, carry out vacuum drying at normal temperatures after 0.1 hour, dried mixed material is crossed 300 mesh sieve granulate, obtain vitamin D3 premix material.
In the vitamin D3 premix material that the present embodiment obtains, the content of vitamin D3 is 5mg/g.
The mensuration of vitamin d3 levels, the vitamin d3 levels uniformity and stability, Residual ethanol in vitamin D3 premix material of the present invention:
1, vitamin d3 levels detects:
1.1 detection methods:
(1) chromatographic condition and system suitability:
Chromatographic column: be packed column with octadecylsilane chemically bonded silica filler;
Mobile phase: water-oxolane-dichloromethane-acetic acid-acetonitrile (20:100:60:6:814);
Determined wavelength: 266nm;
Sample size: 20 μ l;
Number of theoretical plate calculates by vitamin D3 peak and is not less than 4000;
Vitamin D3 reference substance (Chinese pharmaceutical biological product qualification institute);
Test sample: vitamin D3 premix material of the present invention.
1.2 detect sample preparation:
A: the preparation of vitamin D3 premix material test sample of the present invention:
Precision takes vitamin D3 premix material 30g of the present invention, porphyrize; Vitamin D3 premix material of the present invention after precision takes porphyrize appropriate (being about equivalent to vitamin D3 60IU), be placed in the measuring bottle of 25ml, add dissolve with methanol, and be diluted to scale, shake up, filter, the methanol solution of obtained vitamin D3 premix material, precision measures 20 μ l, is vitamin D3 premix material test sample of the present invention.
B: the preparation of matched group vitamin D3 sample:
Accurately weighed vitamin D3 is appropriate, and adding dissolve with methanol and dilute the methanol solution made about containing 0.15 μ l vitamin D3 in every 1ml, is vitamin D3 reference substance.
1.2 detection methods: measure the method under item according to " Chinese Pharmacopoeia " vitamin d3 levels, by the 20 μ l vitamin D3 premix material of the present invention test sample injection liquid chromatography of preparation, with the content of vitamin D3 in the premix material of high effective liquid chromatography for measuring vitamin D3, lucifuge operates, record chromatogram; Another vitamin D3 reference substance is appropriate, is measured in the same method; By external standard method with calculated by peak area, obtain the content of vitamin D3.
2, the vitamin d3 levels uniformity detects:
2.1 detection methods:
(1) chromatographic condition and system suitability:
Chromatographic column: be packed column with octadecylsilane chemically bonded silica filler;
Mobile phase: water-oxolane-dichloromethane-acetic acid-acetonitrile (20:100:60:6:814);
Determined wavelength: 266nm;
Sample size: 20 μ l;
Number of theoretical plate calculates by vitamin D3 peak and is not less than 4000.
(2) content that vitamin D3 premix material test sample of the present invention detects vitamin D3 is got in 3, upper, middle and lower, precision take get 3 places vitamin D3 premix material appropriate (being about equivalent to vitamin D3 60IU) be placed in 25ml measuring bottle, add methanol appropriate, ultrasonic dissolution, and be diluted to required scale, shake up, filter, the method measured under item according to " Chinese Pharmacopoeia " vitamin d3 levels measures the vitamin d3 levels of 3, upper, middle and lower in premix material, and calculates 3, the upper, middle and lower vitamin d3 levels uniformity, content meansigma methods.Wherein, the RSD value of 3 vitamin d3 levels in upper, middle and lower is not qualified higher than 5%, can characterize the vitamin d3 levels uniformity.
3, Residual ethanol detects:
According to residual organic solvent detection method in " Chinese Pharmacopoeia " medicine, ethanol residual in vitamin D3 premix material of the present invention is detected.
4, the stability study of vitamin D3 premix material:
In order to verify the stability of vitamin D3 premix material of the present invention, the present inventor have detected the situation of change of vitamin d3 levels in 24 months in vitamin D3 premix material.
5, result:
3, the table 1 embodiment 1-6 upper, middle and lower vitamin d3 levels uniformity, content meansigma methods and Residual ethanol testing result
The Detection of Stability result of table 2 embodiment 1-6 vitamin D3 premix material
| Product | Time | Character | Vitamin d3 levels (%) |
| Embodiment 1 | 0 month | White powder | 99.78 |
| Embodiment 2 | 0 month | White powder | 99.67 |
| Embodiment 3 | 0 month | White powder | 99.52 |
| Embodiment 4 | 0 month | White powder | 98.91 |
| Embodiment 5 | 0 month | White powder | 99.54 |
| Embodiment 6 | 0 month | White powder | 102.34 |
| Embodiment 1 | 1 month | White powder | 99.13 |
| Embodiment 2 | 1 month | White powder | 99.45 |
| Embodiment 3 | 1 month | White powder | 99.40 |
| Embodiment 4 | 1 month | White powder | 100.11 |
| Embodiment 5 | 1 month | White powder | 100.52 |
| Embodiment 6 | 1 month | White powder | 98.47 |
| Embodiment 1 | 2 months | White powder | 99.67 |
| Embodiment 2 | 2 months | White powder | 99.87 |
| Embodiment 3 | 2 months | White powder | 99.34 |
| Embodiment 4 | 2 months | White powder | 99.47 |
| Embodiment 5 | 2 months | White powder | 99.78 |
| Embodiment 6 | 2 months | White powder | 99.69 |
| Embodiment 1 | 3 months | White powder | 99.89 |
| Embodiment 2 | 3 months | White powder | 100.07 |
| Embodiment 3 | 3 months | White powder | 99.71 |
| Embodiment 4 | 3 months | White powder | 99.44 |
| Embodiment 5 | 3 months | White powder | 99.17 |
| Embodiment 6 | 3 months | White powder | 99.42 |
| Embodiment 1 | 6 months | White powder | 99.99 |
| Embodiment 2 | 6 months | White powder | 99.23 |
| Embodiment 3 | 6 months | White powder | 101.92 |
| Embodiment 4 | 6 months | White powder | 100.89 |
| Embodiment 5 | 6 months | White powder | 98.77 |
| Embodiment 6 | 6 months | White powder | 99.78 |
| Embodiment 1 | 12 months | White powder | 99.76 |
| Embodiment 2 | 12 months | White powder | 99.09 |
| Embodiment 3 | 12 months | White powder | 99.09 |
| Embodiment 4 | 12 months | White powder | 99.67 |
| Embodiment 5 | 12 months | White powder | 99.87 |
| Embodiment 6 | 12 months | White powder | 99.53 |
| Embodiment 1 | 18 months | White powder | 99.77 |
| Embodiment 2 | 18 months | White powder | 100.11 |
| Embodiment 3 | 18 months | White powder | 99.34 |
| Embodiment 4 | 18 months | White powder | 99.47 |
| Embodiment 5 | 18 months | White powder | 99.81 |
| Embodiment 6 | 18 months | White powder | 99.29 |
| Embodiment 1 | 24 months | White powder | 99.18 |
| Embodiment 2 | 24 months | White powder | 99.42 |
| Embodiment 3 | 24 months | White powder | 99.43 |
| Embodiment 4 | 24 months | White powder | 99.44 |
| Embodiment 5 | 24 months | White powder | 99.62 |
| Embodiment 6 | 24 months | White powder | 100.25 |
From table 1, data can be seen, in vitamin D3 premix material of the present invention, the vitamin d3 levels uniformity conforms with the regulations, and does not detect Residual ethanol.From table 2, data can be seen, the vitamin stability of vitamin D3 premix material of the present invention is excellent.Can vitamin D3 premix material of the present invention be used in the preparation of calcium supplement health care product and medicine, conveniently can realize the mixed uniformly object of unclassified stores by vitamin D3 and calcium supplement health care product and medicine.Vitamin d3 levels in calcium supplement health care product and medicine is even, ensure that people each serving vitamin D3 consumption stablize, effectively supplement the vitamin D3 of needed by human body.
Claims (3)
1. a preparation method for vitamin D3 premix material, is characterized in that: comprise the steps:
(1) precision takes vitamin D3 in right amount, and it be dissolved in completely in the ethanol of 80%-100% under room temperature condition, obtained concentration is the alcoholic solution of the vitamin D3 of 2.7 μ g/g-18mg/g;
(2) be the proportioning of 1:0.3-0.7 according to the alcoholic solution mass ratio of the obtained vitamin D3 of solid sorbent material and step (1), it is appropriate that precision takes solid sorbent material, and while stirring the solid sorbent material taken is added in the alcoholic solution of the obtained vitamin D3 of step (1) at ambient temperature, until the alcoholic solution of vitamin D3 absorbs by solid sorbent material completely, obtained mixed material, makes in mixed material not containing remaining alcoholic solution and dry solid sorbent material;
(3) by the mixed material vacuum drying 0.1-5 hour at ambient temperature that step (2) is obtained, then cross 20-300 mesh sieve granulate, obtain vitamin D3 premix material.
2. the preparation method of vitamin D3 premix material according to claim 1, it is characterized in that: the solid sorbent material in described step (2) is sorbitol, mannitol, xylitol, chitin or Polyethylene Glycol, the molecular weight of described Polyethylene Glycol is 6000-10000.
3. the vitamin D3 premix material that the preparation method of vitamin D3 premix material as claimed in claim 1 is obtained, is characterized in that: the content of vitamin D3 is 1.5 μ g/g-10mg/g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510586220.1A CN105193826B (en) | 2015-09-15 | 2015-09-15 | The preparation method of vitamine D3 premix and its vitamine D3 premix obtained |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510586220.1A CN105193826B (en) | 2015-09-15 | 2015-09-15 | The preparation method of vitamine D3 premix and its vitamine D3 premix obtained |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105193826A true CN105193826A (en) | 2015-12-30 |
| CN105193826B CN105193826B (en) | 2019-01-08 |
Family
ID=54942016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510586220.1A Active CN105193826B (en) | 2015-09-15 | 2015-09-15 | The preparation method of vitamine D3 premix and its vitamine D3 premix obtained |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105193826B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107969704A (en) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084880A (en) * | 2006-06-09 | 2007-12-12 | 中国人民解放军军事医学科学院毒物药物研究所 | Biological solid dispersion of vitamin E esters derivatives and preparation method thereof |
| CN102973528A (en) * | 2012-11-19 | 2013-03-20 | 中山大学 | Calcitriol solid lipidic dispersion and preparation method thereof |
-
2015
- 2015-09-15 CN CN201510586220.1A patent/CN105193826B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084880A (en) * | 2006-06-09 | 2007-12-12 | 中国人民解放军军事医学科学院毒物药物研究所 | Biological solid dispersion of vitamin E esters derivatives and preparation method thereof |
| CN102973528A (en) * | 2012-11-19 | 2013-03-20 | 中山大学 | Calcitriol solid lipidic dispersion and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 曾宇君等: "维生素D3固体分散体片制备与稳定性研究", 《中国兽药杂志》 * |
| 李力等: "固体分散体的研究进展", 《药学情报通讯》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107969704A (en) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105193826B (en) | 2019-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101524377B (en) | Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof | |
| CN102973528B (en) | Calcitriol solid lipidic dispersion and preparation method thereof | |
| CN103142487A (en) | High-content toltrazuril soluble powder, as well as preparation method and application thereof | |
| CN103550267B (en) | A kind of ginkgo leaf soft capsule and preparation method thereof | |
| CN105193826A (en) | Preparation method of vitamin D3 premix and vitamin D3 premix prepared through preparation method | |
| CN106727369B (en) | Dequalinium chloride buccal tablet and preparation method thereof | |
| CN102028664B (en) | Citicoline sodium tablets and preparation method thereof | |
| CN102258552B (en) | Method for preparing angelica dahurica decoction pieces | |
| CN103316056A (en) | Radix isatidis coating dispersible tablet and preparation method thereof | |
| CN101816693A (en) | Echinacea purpurea extract powder and preparation method and application thereof | |
| CN103127007B (en) | Sodium glycididazole composition and preparation method thereof | |
| CN103933008A (en) | Simvastatin capsule and preparation method thereof | |
| CN102920893A (en) | Fifteen-component alplily eyesight improving tablet and preparation process thereof | |
| CN106692101A (en) | Mecobalamin tablet and preparation method thereof | |
| CN107737146B (en) | Panax japonicus slice and preparation method thereof | |
| CN102319420A (en) | Application of soft-shelled turtle peptide in preparation of medicines | |
| CN105796498A (en) | Powder coated folic acid and preparation method thereof | |
| CN105288190A (en) | Anoectochilus roxburghii extract tablet and preparation method thereof | |
| CN105521256A (en) | Ranae oviductus and fritillariae ussuriensis bulbus soft capsule as well as preparation method and applications thereof | |
| CN103565764B (en) | mitiglinide calcium composition tablet and preparation method thereof | |
| CN105193760A (en) | High-content glucosamine sulfate tablet and preparation method | |
| CN107569510A (en) | A kind of children's calcium carbonate D3 particulate compositions and preparation method thereof | |
| CN105055353B (en) | A kind of Entecavir tablet and preparation method thereof | |
| CN103142500B (en) | Sustained-release particle of etoposide | |
| CN107569465A (en) | A kind of Nifedipine sustained release tablets and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |